LOCUS       NC_009496              16344 bp    DNA     circular BCT 06-FEB-2008
DEFINITION  Clostridium botulinum A str. ATCC 3502 plasmid pBOT3502, complete
            sequence.
ACCESSION   NC_009496
VERSION     NC_009496.1  GI:148381586
KEYWORDS    complete genome.
SOURCE      Clostridium botulinum A str. ATCC 3502
  ORGANISM  Clostridium botulinum A str. ATCC 3502
            Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
            Clostridium.
REFERENCE   1  (bases 1 to 16344)
  AUTHORS   Sebaihia,M., Peck,M.W., Minton,N.P., Thomson,N.R., Holden,M.T.,
            Mitchell,W.J., Carter,A.T., Bentley,S.D., Mason,D.R., Crossman,L.,
            Paul,C.J., Ivens,A., Wells-Bennik,M.H., Davis,I.J.,
            Cerdeno-Tarraga,A.M., Churcher,C., Quail,M.A., Chillingworth,T.,
            Feltwell,T., Fraser,A., Goodhead,I., Hance,Z., Jagels,K., Larke,N.,
            Maddison,M., Moule,S., Mungall,K., Norbertczak,H.,
            Rabbinowitsch,E., Sanders,M., Simmonds,M., White,B., Whithead,S.
            and Parkhill,J.
  TITLE     Genome sequence of a proteolytic (Group I) Clostridium botulinum
            strain Hall A and comparative analysis of the clostridial genomes
  JOURNAL   Genome Res. 17 (7), 1082-1092 (2007)
   PUBMED   17519437
REFERENCE   2  (bases 1 to 16344)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAY-2007) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 16344)
  AUTHORS   Sebaihia,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2006) Sebaihia M., Sulston Laboratories, Wellcome
            Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton,
            Cambridge, CB10 1SA, UNITED KINGDOM
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AM412318.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..16344
                     /organism="Clostridium botulinum A str. ATCC 3502"
                     /mol_type="genomic DNA"
                     /strain="ATCC 3502"
                     /db_xref="taxon:413999"
                     /plasmid="pBOT3502"
     gene            complement(1..3585)
                     /gene="dnaE"
                     /locus_tag="CBOP01"
                     /db_xref="GeneID:5188018"
     CDS             complement(1..3585)
                     /gene="dnaE"
                     /locus_tag="CBOP01"
                     /EC_number="2.7.7.7"
                     /note="catalyzes DNA-template-directed extension of the
                     3'-end of a DNA strand by one nucleotide at a time.
                     Proposed to be responsible for the synthesis of the
                     lagging strand. In the low GC gram positive bacteria this
                     enzyme is less processive and more error pron"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III DnaE"
                     /protein_id="YP_001256127.1"
                     /db_xref="GI:148381587"
                     /db_xref="GeneID:5188018"
                     /translation="MSDKKFTHLHLHTGYSLLDGAGKINNIIASAKELGMDSIAITDH
                     GAMYGCVDFYKAAKNAGLKAIIGCEVYIVPKSMSIKNSDPNNKIYHLVLLVKNEIGYK
                     NLIKIVSKASIDGFYYKPRTDHQFLKDHSEGLIALSACLGGEIQSNLLNENKEKAKEI
                     ALFYKSIFKDGFYLELQYHGNDAERKVNDMNIRLARELKIPLVATNDVHYIEQKDSKF
                     HDILLCIQTGKTVNKENRLRYPSDQFYLKSADEMWEMFSHVPEALKNTEKIAEQCNFH
                     YDFHTSKLPKFLLPEGTDPFEYMKKFCFKGLIKRCDLFRDLLTKSFNINEIIALGKEN
                     EEAKIYIDRLQYELSVIDHMGYVDYFLIVSDFIKFANEKKIPTGPGRGSGAGSLVAYT
                     LGITKIDPIKYGLIFERFLNPERISMPDIDSDFCYERRGEIIDYVVEKYGKENVSQII
                     TFGTMAARVCIRDVGRAMNYSYVEVDKIAKMIPIVPGIIITIDKALALNPELKNEYEN
                     NLRVKELIDVSMNLEGLPRHSSTHAAGIIISSSPIGDYVPLQKNEHNIVSQFDMTTLD
                     ELGFLKMDFLGLKTLTVLKDAVDMIMQNHNVDIDLDKIDINDKEVYKMIGEGKTIGIF
                     QLESTGMTSFMKELKPDSLEDIIAGISLYRPGPIDEIPKYIENKKNPDKITYLTPQLE
                     PILKITYGCLVYQEQVMEIVRKLAGYSMGRSDLVRRAMSKKKHKVMEEERKNFIYGIV
                     KEDGEIEVPGCIRNEVSEKIGNELFDSMMDFASYAFNKSHAVAYALVAYQTAYLMKYY
                     PAEYIAAKLNSVMGDNGKVAYYINYAESLGIQVLPPDINESFSKFIVEDNTIRFGLDA
                     IKNVGIGAAKIIVKSRKKNGNFKSLIDFASKIDLTTINKRAIESLIKAGAFDCFKVFR
                     SRLLAVYEKVLDSISNQRKRNIDGQVSLFNADNTIVNIPIIKYPEIKEFDKKYLLAME
                     KEMLGIYITGHPLDEYAQSLKIQTSIRIEKILCSHNKVLNDDSIIEISSDNNIIRGDI
                     NDGERVVIGGIITKVSRKITRNNTIMAFLKLEDLSGIIEVIVFPKTLENVNPLINEDS
                     LVVIRGRVSLAEDELPKLICEKIHPLEKLNLSKVYIRVKDNKKVRTANKFLKTILKSH
                     KGDTPIYIFSEKEKQNFRLSKNLLISLDEDILSTLRSYFGDENIKVVD"
     misc_feature    complement(235..726)
                     /gene="dnaE"
                     /locus_tag="CBOP01"
                     /note="superfamily hit to SSF50249, Nucleic acid-binding
                     proteins, score 1.5e-10"
                     /inference="protein motif:Superfamily:SSF50249"
     misc_feature    complement(244..480)
                     /gene="dnaE"
                     /locus_tag="CBOP01"
                     /note="HMMPfam hit to PF01336, OB-fold nucleic acid
                     binding domain, score 4.4e-14"
                     /inference="protein motif:Pfam:PF01336"
     misc_feature    complement(1357..2856)
                     /gene="dnaE"
                     /locus_tag="CBOP01"
                     /note="HMMPfam hit to PF07733, Bacterial DNA polymerase
                     III alpha sub, score 1.2e-269"
                     /inference="protein motif:Pfam:PF07733"
     misc_feature    complement(2797..3573)
                     /gene="dnaE"
                     /locus_tag="CBOP01"
                     /note="superfamily hit to SSF89550, PHP domain, score
                     3.4e-59"
                     /inference="protein motif:Superfamily:SSF89550"
     misc_feature    complement(2935..3327)
                     /gene="dnaE"
                     /locus_tag="CBOP01"
                     /note="HMMPfam hit to PF02811, PHP domain C-terminal
                     region, score 3.2e-33"
                     /inference="protein motif:Pfam:PF02811"
     misc_feature    complement(3370..3567)
                     /gene="dnaE"
                     /locus_tag="CBOP01"
                     /note="HMMPfam hit to PF02231, PHP domain N-terminal
                     region, score 3.3e-32"
                     /inference="protein motif:Pfam:PF02231"
     gene            complement(3754..3951)
                     /locus_tag="CBOP02"
                     /db_xref="GeneID:5188036"
     CDS             complement(3754..3951)
                     /locus_tag="CBOP02"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_001256128.1"
                     /db_xref="GI:148381588"
                     /db_xref="GeneID:5188036"
                     /translation="MTYYFNDDSVQLENYFFEADELGNINVYNADTMQFLDLIHVSYR
                     YDRYKFLDNCKEWICKKNEGI"
     gene            complement(3951..4142)
                     /locus_tag="CBOP03"
                     /pseudo
                     /db_xref="GeneID:5188020"
     misc_feature    complement(3987..4133)
                     /locus_tag="CBOP03"
                     /note="BlastProDom hit to PD008230,
                     Q9ZAN0_STAAU_Q9ZAN0;,score 0.0009"
                     /pseudo
                     /inference="protein motif:ProDom:PD008230"
     gene            4356..4556
                     /locus_tag="CBOP04"
                     /db_xref="GeneID:5188021"
     CDS             4356..4556
                     /locus_tag="CBOP04"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_001256129.1"
                     /db_xref="GI:148381589"
                     /db_xref="GeneID:5188021"
                     /translation="MYRLNKGFVKLSIDNHVEFVNRELGKDKKYGINKSTIISIFTTK
                     GYKYNAELRCYIKDIKKLKECN"
     gene            4798..5343
                     /locus_tag="CBOP005"
                     /db_xref="GeneID:5188022"
     CDS             4798..5343
                     /locus_tag="CBOP005"
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific recombinase"
                     /protein_id="YP_001256130.1"
                     /db_xref="GI:148381590"
                     /db_xref="GeneID:5188022"
                     /translation="MELVQPIRDKEVINKFKNELLKKGYRNYMLFVIGINTGLRISDI
                     LKLKVEDVKDKTHIVIREQKTSKRTRVLINSMLREDIEKYIEGMDNTEYLFKSRNGKN
                     KPITRVQAYRILSEVGKHLGMSEVGTHTLRKTFGYWHYKQYKDVAILQDIFNHSAPSI
                     TLKYIGINDDIKDNTIENFYL"
     misc_feature    4810..5328
                     /locus_tag="CBOP005"
                     /note="superfamily hit to SSF56349, DNA breaking-rejoining
                     enzymes, score 6.1e-34"
                     /inference="protein motif:Superfamily:SSF56349"
     misc_feature    4816..5319
                     /locus_tag="CBOP005"
                     /note="HMMPfam hit to PF00589, Phage integrase
                     family,score 2e-15"
                     /inference="protein motif:Pfam:PF00589"
     gene            5464..6117
                     /locus_tag="CBOP06"
                     /db_xref="GeneID:5188019"
     CDS             5464..6117
                     /locus_tag="CBOP06"
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="YP_001256131.1"
                     /db_xref="GI:148381591"
                     /db_xref="GeneID:5188019"
                     /translation="MYDNIKVLLKYYRGDDMDRTDFDKLEVQDQVIYINKQLGEGSTL
                     RDIASNLNIARSTLRDRFKKIGYIYNKKLNTYSKTNNEYNKNNTNVLYKEPVKKQNTL
                     EIESYKSNTIVSNKELQSIKEVNNLKKEVFELINNKDIILEMIKDYKSNTKIIDIPQL
                     DINNLPVEMQKDITTKSIKVYKPIYNLFNKLCEEYSSIKKQDLISLALYEFYIRYKK"
     misc_feature    5569..5685
                     /locus_tag="CBOP06"
                     /note="superfamily hit to SSF47954, Cyclin-like, score
                     0.0053"
                     /inference="protein motif:Superfamily:SSF47954"
     misc_feature    5587..5652
                     /locus_tag="CBOP06"
                     /note="Predicted helix-turn-helix motif with score
                     1388.000, SD 3.91 at aa 42-63, sequence
                     STLRDIASNLNIARSTLRDRFK"
     gene            6306..6569
                     /locus_tag="CBOP07"
                     /db_xref="GeneID:5188023"
     CDS             6306..6569
                     /locus_tag="CBOP07"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_001256132.1"
                     /db_xref="GI:148381592"
                     /db_xref="GeneID:5188023"
                     /translation="MLNVGRKRGKIKTSFFKNKIKKSFNSYISYGNTLYKPIQLCTGI
                     HKRTLERPYNLLFNYRIDYTKLLREFQAFFSMNVLRSAFLMFK"
     gene            6619..6810
                     /locus_tag="CBOP08"
                     /db_xref="GeneID:5188024"
     CDS             6619..6810
                     /locus_tag="CBOP08"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_001256133.1"
                     /db_xref="GI:148381593"
                     /db_xref="GeneID:5188024"
                     /translation="MKRVKSCRKCEFYNEDEEFNCTNFKMVILDFNNARKCIYYQERM
                     GRRKRCKTCMYLSTTYKQV"
     gene            6921..7064
                     /locus_tag="CBOP09"
                     /db_xref="GeneID:5188025"
     CDS             6921..7064
                     /locus_tag="CBOP09"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_001256134.1"
                     /db_xref="GI:148381594"
                     /db_xref="GeneID:5188025"
                     /translation="MLRSISRKNKRPTNQSVLLPLEGRKTSQKNICKILTSVCDCPSW
                     GRR"
     gene            7133..7282
                     /locus_tag="CBOP10"
                     /db_xref="GeneID:5188026"
     CDS             7133..7282
                     /locus_tag="CBOP10"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_001256135.1"
                     /db_xref="GI:148381595"
                     /db_xref="GeneID:5188026"
                     /translation="MDIRIPLIPIRIKRSKKYIPLCSNIIYIRAQGGESRFPYQAYQI
                     KIKIV"
     gene            7704..8258
                     /locus_tag="CBOP11"
                     /db_xref="GeneID:5188027"
     CDS             7704..8258
                     /locus_tag="CBOP11"
                     /note="Weakly Similar to Pediococcus pentosaceus plasmid
                     orf1 TR:Q9X3B9 (EMBL:AF069302) (111 aa) fasta scores: E():
                     0.0014, 33.000 38d in 100 aa, and to Pediococcus
                     pentosaceus mobc-like protein TR:Q9RHE2 (EMBL:AF033858)
                     (73 aa) fasta scores: E(): 0.6, 36.111 38d in 72 aa, and
                     to Pasteurella multocida, mbecy or mobC TR:Q51926
                     (EMBL:U57647) (101 aa) fasta scores: E(): 0.77, 29.808 38d
                     in 104 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="possible mobilisation protein"
                     /protein_id="YP_001256136.1"
                     /db_xref="GI:148381596"
                     /db_xref="GeneID:5188027"
                     /translation="MNKEKAEEIIESVQGNIKHSDMILTDDERALLEEYILGNITREE
                     YIEKSLEDVQKDNIRYGIKGEKILDSTINLSENCKVNRKRNKQIVIRATRKEFNTIKN
                     KVKKSKLSQNEYLLKCALDKRIVVVDGLKDLNVELKRIGNNLNQLIKSVHEGKANCSK
                     ELLEINEEMKEVWQLLRQLTPKAL"
     misc_feature    8100..8225
                     /locus_tag="CBOP11"
                     /note="HMMPfam hit to PF05713, Bacterial mobilisation
                     protein (MobC), score 0.00019"
                     /inference="protein motif:Pfam:PF05713"
     gene            8219..8989
                     /locus_tag="CBOP12"
                     /db_xref="GeneID:5188028"
     CDS             8219..8989
                     /locus_tag="CBOP12"
                     /note="Similar to Staphylococcus aureus Plasmid pS194 rlx
                     protein SW:RLX1_STAAU (P12054) (320 aa) fasta scores: E():
                     6.8e-15, 33.333 38d in 252 aa, and to Fusobacterium
                     nucleatum DNA relaxation protein homolog rlxA TR:Q9L9V7
                     (EMBL:AF159249) (348 aa) fasta scores: E(): 8.4e-15,36.458
                     38d in 288 aa, and to Staphylococcus epidermidis
                     mobilization protein moba2 TR:Q9R968 (EMBL:AF045472) (337
                     aa) fasta scores: E(): 4.4e-13, 25.681 38d in 257 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="possible mobilisation protein"
                     /protein_id="YP_001256137.1"
                     /db_xref="GI:148381597"
                     /db_xref="GeneID:5188028"
                     /translation="MAVIKAVNSKSSLDGIIKYVTREEKTEERLITGKDCSPSNVLEE
                     MKVTKEIFNKTTGRQYKHFIQSFDPNDNLDYMKANKIGLEWAEKIFKGFEVLISTHKD
                     KGHIHNHFVVNSVSFEDGRKLRYSNKELQNFKNVNDRICEREGLNIVREVSKEITSFN
                     HNKYKVIEKAFKGMGESYLLNTGLEVSNSLKVSKTKEEFIKSMEEKGYKVNWKDTRKY
                     ITFTTPEGRKIRNSNLQNTLKNDKFTKEGMENELRYNR"
     misc_feature    8243..8968
                     /locus_tag="CBOP12"
                     /note="HMMPfam hit to PF03432, Relaxase/Mobilisation
                     nuclease domain, score 8.3e-39"
                     /inference="protein motif:Pfam:PF03432"
     gene            9252..9509
                     /locus_tag="CBOP13"
                     /db_xref="GeneID:5188029"
     CDS             9252..9509
                     /locus_tag="CBOP13"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_001256138.1"
                     /db_xref="GI:148381598"
                     /db_xref="GeneID:5188029"
                     /translation="MVDKLNEILKGLSIKLDKVYKVYIERMGTETEKKIQALNELQKE
                     AENRCESYYNRKTIIAYLIYINLAITPILFFIIIYIQFFKK"
     misc_feature    9423..9491
                     /locus_tag="CBOP13"
                     /note="1 probable transmembrane helix predicted for CBOP13
                     by TMHMM2.0 at aa 58-80"
                     /inference="protein motif:TMHMM:2.0"
     gene            9738..9929
                     /locus_tag="CBOP14"
                     /db_xref="GeneID:5188030"
     CDS             9738..9929
                     /locus_tag="CBOP14"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_001256139.1"
                     /db_xref="GI:148381599"
                     /db_xref="GeneID:5188030"
                     /translation="MLFLSYFSEKVFFMQHHVKKNGNTLPYYGVYVNSEKRNNCPNYS
                     LYCNKYKYILFSWIYINNV"
     gene            10033..11325
                     /locus_tag="CBOP15"
                     /db_xref="GeneID:5188031"
     CDS             10033..11325
                     /locus_tag="CBOP15"
                     /codon_start=1
                     /transl_table=11
                     /product="putative bacteriocin biosynthesis protein"
                     /protein_id="YP_001256140.1"
                     /db_xref="GI:148381600"
                     /db_xref="GeneID:5188031"
                     /translation="MYPQLTDNSFVKQTPDKEAHVFSFFINEMRSYVSINESASSILG
                     LCNGMHSIEDIISILSNKYEEDPNVVKKNVQTFLDPFIKNSIVRDNKVEFSNRNIVNG
                     SLEVYYPHALCWEITDYCPLNCRHCYLPEKNNSILSRDNIDNVLEIIDSAGIQQVQVT
                     GGEALTHPELEYIIDSLINRGIITSISTSGFNFTNDMFKYLVKLKEVKGSKLRVSLDG
                     DKNIHNYIRKNEYAYNNAIEFIKTAVKNGIICQVETSVINQSKQDLEDLVVLVKELGV
                     SSIEIARISDQGNARKNNLELVWSPKEFDDFLYQLNSKYANETFKIRLPKEEKNKNCG
                     AGYKIIRIKPNFDVTPCPMLEFRLGNLHKDTMFQIMSKCGNIFHEFEAPQNKFCSECE
                     NKDTCDHCIASGFNSKDKVKDCRWFRNIEYCLKPFLDR"
     misc_feature    10153..10188
                     /locus_tag="CBOP15"
                     /note="PS00442 Glutamine amidotransferases class-I active
                     site.
                     ScanRegExp hit to PS00442, GATASE_TYPE_I, score NA"
                     /inference="protein motif:ProSite:PS00442"
     misc_feature    10372..10845
                     /locus_tag="CBOP15"
                     /note="HMMPfam hit to PF04055, Radical SAM
                     superfamily,score 1.4e-23"
                     /inference="protein motif:Pfam:PF04055"
     gene            11531..11692
                     /gene="btcB"
                     /locus_tag="CBOP16"
                     /db_xref="GeneID:5188032"
     CDS             11531..11692
                     /gene="btcB"
                     /locus_tag="CBOP16"
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin"
                     /protein_id="YP_001256141.1"
                     /db_xref="GI:148381601"
                     /db_xref="GeneID:5188032"
                     /translation="MEKPKITNANMVACSGNPYAAIAMLGLACGADFAYCQMPSVSDL
                     WGSGTAKAL"
     misc_feature    11567..11635
                     /gene="btcB"
                     /locus_tag="CBOP16"
                     /note="1 probable transmembrane helix predicted for btcB
                     by TMHMM2.0 at aa 13-35"
                     /inference="protein motif:TMHMM:2.0"
     misc_feature    11585..11617
                     /gene="btcB"
                     /locus_tag="CBOP16"
                     /note="PS00013 Prokaryotic membrane lipoprotein lipid
                     attachment site."
                     /inference="protein motif:ProSite:PS00013"
     gene            11905..13080
                     /locus_tag="CBOP17"
                     /db_xref="GeneID:5188035"
     CDS             11905..13080
                     /locus_tag="CBOP17"
                     /note="May be involved in bacteriocin
                     maturation/secretion. Similar to Sulfolobus solfataricus
                     zn-dependent protease, TldD protein homolog, putative tldD
                     TR:AAK40965 (EMBL:AE006693) (443 aa) fasta scores: E():
                     5.2e-13, 30.736 38d in 231 aa, and to Escherichia coli
                     tldd protein tldd or b3244 SW:TLDD_ECOLI (P46473) (481 aa)
                     fasta scores: E(): 1.6e-11, 27.306 38d in 271 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="TldD family protein"
                     /protein_id="YP_001256142.1"
                     /db_xref="GI:148381602"
                     /db_xref="GeneID:5188035"
                     /translation="MNYKQSVYTIQLKYIKDDFEYIVDSFSGEREETIRNIKLNTCKN
                     LFDDVQLNISTPYLINLKKSLRYIKKDLEKQDINLSIFMNLHNERVLIDNEEEDNRSY
                     GFLRLICKDNDNNMHIDDIPILSCNPIDLEDKINYYAKKYISMKNLHDIREQVSFESI
                     PHILSPKAAGYFIHEIVGHTLESDFYSYYKDKYENMKISKKLTVTDSINGYNRLIGLQ
                     GYDDVGTKIESLTLINKGKIQNMLAIKKEDSFDHKLYGVARRASYKFEVLPRMRSTYI
                     HPFDDMDQQDILDKYENAIFVNEIFLGGVDHKSGKYNLNGNGFIVKNGELQNFIGDLR
                     ISGDILKDISSIDYIGKDFDMFGNYCEKFGQFVRVGSGGPTISISSLNARGVLYGRR"
     gene            13067..14290
                     /locus_tag="CBOP18"
                     /db_xref="GeneID:5188033"
     CDS             13067..14290
                     /locus_tag="CBOP18"
                     /note="May be involved in bacteriocin
                     maturation/secretion. Similar to Buchnera aphidicola
                     (subspAcyrthosiphon pisum) (Acyrthosiphon pisum pmba
                     protein homolog pmba or bu089 SW:PMBA_BUCAI (P57191) (446
                     aa) fasta scores: E(): 0.19, 23.797 38d in 395 aa, and to
                     Escherichia coli pmba protein pmba or tlde or b4235
                     SW:PMBA_ECOLI (P24231) (450 aa) fasta scores: E():
                     0.98,20.716 38d in 391 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="PmbA family"
                     /protein_id="YP_001256143.1"
                     /db_xref="GI:148381603"
                     /db_xref="GeneID:5188033"
                     /translation="MEEDKRIEKRLLSKGIMEYKIIRTILRGMKYKEYFGSVSIEDLS
                     DDKILVLFKTEEGIAKFTVSSFQSDNIIDRIIETSMKNQMKMSLQWHDDNFSDVKIEQ
                     NENYNRFYKFNSNDYIMWIKKEIDNISKKIKFTFNTIYTINVNKYCLRTNKDYIEQYN
                     TSSEFLCIENKTFKRRSKLSNRFLKDDIALSIIKQLNNDDIPRNNINLNSKQRILLKA
                     KGLSDFLNVYISLYYANYIYSNQSFIKTNYIGKQISKSNFDLIAIPYNGIKFDSEGSR
                     IFKKLIVGSGKLINLLSNNSFSEYFNINSFGNASLDTHNTVSHQRLIFTCKNSERIVS
                     KSVDLIIHQFENAYIDFEDNEVFRGNAICSDKSGYFRTTISFNLKYIFNNIYPIGNKS
                     TWINNVYCQDVIILR"
     misc_feature    13199..13501
                     /locus_tag="CBOP18"
                     /note="superfamily hit to SSF75001, Dipeptidyl peptidase I
                     (cathepsin C), exclusion domain, score 0.015"
                     /inference="protein motif:Superfamily:SSF75001"
     gene            14411..16054
                     /locus_tag="CBOP19"
                     /db_xref="GeneID:5188034"
     CDS             14411..16054
                     /locus_tag="CBOP19"
                     /note="May be involved in bacteriocin secretion. Contains
                     IM domain at N-terminus and ATP-binding domain at
                     C-terminus. Similar to Campylobacter jejuni lipid export
                     ABC transport protein msba or cj0803 TR:Q9PPB7
                     (EMBL:AL139076) (580 aa) fasta scores: E(): 4.6e-36,28.755
                     38d in 546 aa, and to Synechocystis sp hlyb family hlyb or
                     sll1180 TR:P74176 (EMBL:D90913) (1011 aa) fasta scores:
                     E(): 1e-32, 26.488 38d in 521 aa, and to Leuconostoc
                     mesenteroides mesentericin y105 transport ATP-binding
                     protein MesD mesD SW:MESD_LEUME (Q10418) (722 aa) fasta
                     scores: E(): 3.1e-31, 27.370 38d in 559 aa"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-family secretion protein"
                     /protein_id="YP_001256144.1"
                     /db_xref="GI:148381604"
                     /db_xref="GeneID:5188034"
                     /translation="MGKLRSLLKLKPFLQKYKLLLFFALIGIILGSIVAIPVPYIIGK
                     IMDDVLIGSKSFNEFYFYIGIITILYVLKYFISITSNYLSSKFNNFMSNDLRFILIDK
                     VMDLPMDYLANVEKGYLQGRISECDSITAIFSGTIISILLSTVNAVLSVSTMFVINYK
                     LAIAVLILVPFFFILAKFSNHALTKNTKKMLEDSAILNAECFEIINGVEDIKILNGKA
                     YSLGKFKKKLDQFIKITLKQNKTMLLLSQNVVGVNDVGTLLILLIAGNLIIKGEFTVG
                     LYTTFSLYSSKIFSSTQLLANIGPSLKQACLSIERLYELIDMDDENKGKNKHLNKKIE
                     SIKLENVTFKYKNSIKNVLDSLNFEINKGEKVLISGENGTGKSTLIKLLVGLYEPTEG
                     RILYNNLDLATINNESLRSRIGIVSQNMFLFKGTVLDNILYGQNQKKRKDVEKLIIKL
                     NLENYISRLPEGLDSKIIQNNNGISGGQTQVIAFIRAVLSNKDIIILDEPISNVDAET
                     RNIILNILKESKFDGILIIISHFTKGMEFINKTIKVGKK"
     sig_peptide     14411..14515
                     /locus_tag="CBOP19"
                     /product="hypothetical protein"
                     /note="probability 1.000, with cleavage site probability
                     0.548 between residues 35 and 36"
                     /inference="protein motif:SignalP:2.0"
     misc_feature    14438..15346
                     /locus_tag="CBOP19"
                     /note="superfamily hit to SSF90123, Multidrug resistance
                     ABC transporter MsbA, N-terminal domain, score 3.6e-61"
                     /inference="protein motif:Superfamily:SSF90123"
     misc_feature    order(14468..14536,14594..14662,14795..14863,14891..14959,
                     15137..15205)
                     /locus_tag="CBOP19"
                     /note="5 probable transmembrane helices predicted for
                     CBOP19 by TMHMM2.0 at aa 20-42, 62-84, 129-151, 161-183
                     and 243-265"
                     /inference="protein motif:TMHMM:2.0"
     misc_feature    14474..15286
                     /locus_tag="CBOP19"
                     /note="HMMPfam hit to PF00664, ABC transporter
                     transmembrane region, score 2.5e-17"
                     /inference="protein motif:Pfam:PF00664"
     misc_feature    15416..16048
                     /locus_tag="CBOP19"
                     /note="superfamily hit to SSF52540, P-loop containing
                     nucleoside triphosphate hydrolases, score 1e-49"
                     /inference="protein motif:Superfamily:SSF52540"
     misc_feature    15497..16045
                     /locus_tag="CBOP19"
                     /note="HMMPfam hit to PF00005, ABC transporter, score
                     3.7e-45"
                     /inference="protein motif:Pfam:PF00005"
     misc_feature    15518..15541
                     /locus_tag="CBOP19"
                     /note="PS00017 ATP/GTP-binding site motif A (P-loop)."
                     /inference="protein motif:ProSite:PS00017"
     misc_feature    15833..15958
                     /locus_tag="CBOP19"
                     /note="BlastProDom hit to PD000006,
                     Q97IT2_CLOAB_Q97IT2;,score 7e-11"
                     /inference="protein motif:ProDom:PD000006"
ORIGIN      
        1 ttaatccacg acttttatat tttcatctcc aaaatagctc cttaatgtag acagtatatc
       61 ttcatctaag gatatcaata aatttttact aagtctaaaa ttttgtttct ccttttcaga
      121 gaatatatat ataggggtat ctcccttatg agattttagt atagttttta aaaacttatt
      181 tgctgttctt acttttttat tatccttaac tctaatatat accttagata aattgagttt
      241 ttcaagtgga tgtatttttt cacatattag tttaggtaat tcatcttctg ctagggatac
      301 tctacctctt ataactacca atgaatcttc atttatcagt ggattaacat tttctaaggt
      361 tttggggaaa actattactt caataattcc actaagatct tcaagcttta aaaaagccat
      421 aatagtatta tttctagtta tttttcttga tactttagtt attattcctc caataacaac
      481 tctttcacca tcatttatat ctcctcttat aatgttatta tcgcttgata tttctataat
      541 tgaatcatca tttagcactt tgttatgaga acataagatt ttttcaattc taatagaagt
      601 ttgaattttt aaactctgtg catattcatc taaaggatgt cctgttatat aaattcctag
      661 catttctttt tccattgcaa gtagatattt tttatcaaat tcttttattt caggatattt
      721 tattataggt atgttaacta ttgtattatc agcattaaaa agacttacct gaccatctat
      781 attccttttt ctttgattac tgatactgtc taaaactttt tcatatactg caagaagtct
      841 agatctaaat actttgaagc aatcaaaagc acctgctttt ataagacttt ctattgctct
      901 tttatttatg gttgttaaat ctattttact agcaaagtca ataagtgact taaagtttcc
      961 attctttttt cttgatttaa caataatttt cgctgcacct atacctacat tttttattgc
     1021 atcaagacca aatcttattg tgttatcctc aactataaat ttagaaaaac tttcatttat
     1081 atctggggga agtacctgta ttcccaaact ttcagcataa tttatataat atgctacttt
     1141 cccattgtcc cccatcaccg aatttagttt tgcggcaata tattcagctg gataatactt
     1201 cattaagtat gcagtttgat aagctaccag agcataagcg acagcatgac ttttattaaa
     1261 tgcataggag gcaaaatcca tcatagaatc aaatagttca ttccctattt tttctgatac
     1321 ttcatttcta atgcatccag ggacttctat ttctccatct tccttaacaa ttccataaat
     1381 aaagttcttt ctttcctctt ccataacttt atgttttttc ttagacatag cccttcttac
     1441 aaggtcgcta cgtcccattg aatagcccgc tagttttcta acaatttcca taacttgttc
     1501 ttgataaact aaacaaccat atgtaatctt caatattggt tctaattgtg gtgtcaaata
     1561 cgttatttta tcaggatttt ttttattttc tatatatttt ggaatttcat ctattggccc
     1621 tggtctatat agtgatattc ctgctataat atcctctaat gaatctggtt taagttcctt
     1681 cataaaagaa gtcatacctg ttgattctaa ctgaaaaatt ccaatagttt tgccttctcc
     1741 aatcatctta tatacttctt tatcattaat atctatttta tctaagtcta tatctacatt
     1801 gtggttttgc attatcatat caacagcatc tttcaataca gttaaagtct ttagccctaa
     1861 aaaatccatc tttaaaaacc caagttcgtc aagtgtagtc atatcaaatt gggatacaat
     1921 attatgctca tttttttgaa gtggaacata gtccccgata gggcttgatg atataataat
     1981 tcccgcagca tgtgttgaag aatgtcttgg cagtccctct aaattcatac taacatcaat
     2041 taattcttta acccttaaat tattttcata ctcattcttt aattctggat ttagagctaa
     2101 tgccttatct atagtaatta ttattccagg cacaataggt atcatttttg cgattttatc
     2161 cacttctaca taagagtagt tcatggctct tcctacatct ctaatacaaa ctcttgcagc
     2221 cattgttcca aatgttatta tttgtgatac gttttccttt ccgtattttt ctactacata
     2281 atctataatc tctcctcttc tttcatagca aaaatcgcta tctatatctg gcatgcttat
     2341 tctttcagga ttaaggaatc tttcaaagat aagaccatat tttattggat caatcttagt
     2401 tattcctaaa gtatatgcaa ctaaagatcc tgctccagag cctcttcctg ggcctgtggg
     2461 tatttttttc tcatttgcaa actttataaa atcgctaact attaaaaagt aatctacata
     2521 tcccatatga tctattacag aaagttcata ttggagtcta tctatataaa tcttagcttc
     2581 ttcattttct ttacccaatg ctattatttc atttatatta aatgatttag ttaagagatc
     2641 tctaaacaaa tcacatcgct taattagacc tttaaaacaa aattttttca tatattcaaa
     2701 aggatctgtt ccttctggta gtaaaaattt gggaagcttt gaagtatgaa aatcataatg
     2761 aaaattgcat tgttctgcta ttttctcagt attttttaaa gcttctggaa catgtgaaaa
     2821 catctcccac atttcgtctg cagacttcaa atagaactga tctgaaggat atcttagtct
     2881 attctcttta tttacagttt tccctgtttg tatacataat agaatatcat gaaacttaga
     2941 atctttttgt tctatatagt ggacatcatt tgtagctaca agtggtattt taagttctct
     3001 agctagcctt atattcatat cattaacttt tctctcagcg tcattaccat gatactgaag
     3061 ttcaagataa aaaccatctt tgaatattga tttataaaat aatgcaattt cttttgcttt
     3121 ttccttattt tcatttaaca aatttgattg tatttctcca cctaagcaag cacttaaagc
     3181 tattagccct tcactatggt cttttaaaaa ttggtgatca gttctaggtt tataataaaa
     3241 accatcaata gatgcctttg aaactatctt aattaaattt ttataaccta tttcattttt
     3301 cacaagaagc actaggtgat aaatcttgtt attaggatca ctattcttta tactcattga
     3361 tttggggaca atataaactt cacatcctat aatagccttc aatcctgcat ttttagcggc
     3421 tttataaaaa tcaacacatc catacatagc tccatgatct gttatagcta tactatccat
     3481 acccagttct ttagcactgg ctattatatt atttatcttt ccagccccat ccaataagct
     3541 atatccagta tgaagatgaa gatgtgtaaa ctttttatca ctcaaaaact ggtcctcctt
     3601 ttttattatt tttgttaatt aatcatattc aagataattc taatatgatt tttcccaata
     3661 taaaaagaag ctcatgagat atttattata ttgttaaatc aagtatctca gttcctaaat
     3721 atatgaatac accttaaaaa gatgtgaatc gccttaaatc ccctcatttt ttttgcatat
     3781 ccattcttta caattgtcta aaaacttata acgatcatat ctatagctta catgaattaa
     3841 gtctaagaat tgcatagtat cagcgttgta aacatttata ttgcccaatt cgtcagcttc
     3901 aaagaagtaa ttctctagct gcacgctatc atcattaaaa taataagtca ttattcttcc
     3961 acctctgttt caatacaatt aactttatct tttcctaaag aataaaattg ggtcattaaa
     4021 tatcgagcgc tactttcatc acctttatga attaatttat tactaagaat aattttatca
     4081 gttctacggt ttattaaatt agcatcttca attaatttaa atatttctaa gacaacaatc
     4141 ttttaatctc atgataactc acaaagttct catctaaccg tggtttatac ttataataat
     4201 attacataac taaataaaag taaaaaatac tttaatatag aatttatata ataataactt
     4261 atagatattt atagttaata tatacctata ggatatatat attaaactgt tataaaaata
     4321 taaattatat ataaattatt aaattgtatg aggtgatgta taggttgaat aaaggatttg
     4381 taaaattaag tatagataat catgtggaat ttgttaatag agaattgggg aaagataaaa
     4441 aatatgggat aaataaaagt acaattataa gtatatttac aacaaaaggg tataaatata
     4501 atgcagaatt aagatgttat ataaaagata ttaaaaagtt aaaagaatgc aactagaaat
     4561 caatggggca tcacatacat acttacaaca atattaaaaa aatattttaa tatcactttt
     4621 gcaatgtaac gtaatgatga ttttgttaca ttgaagccga ataggctata agtattgcaa
     4681 tgtaaatact tatagcctat tttttattat tctactggga aagcatttat gtaaatgtaa
     4741 catattgtat ttataagtat catttaatgt attataatgt atgtaagagg tgataaaatg
     4801 gaattagttc aacctataag ggataaagaa gttataaata aatttaagaa tgaattactt
     4861 aaaaagggtt ataggaacta tatgctcttt gtgataggaa taaatacagg tttaagaata
     4921 tcagatatat taaagcttaa ggttgaagat gtaaaggata aaacacatat agtgatccga
     4981 gagcaaaaga caagtaaaag gacacgagtt ttaataaatt caatgttaag agaggatatt
     5041 gaaaagtata tagagggtat ggataataca gaatacctat ttaaaagccg taatgggaaa
     5101 aataagccta taacgagggt acaagcctat agaatattat cagaggtagg aaagcatcta
     5161 ggaatgtctg aggtgggtac acacactctc agaaagactt ttggctattg gcactataaa
     5221 caatataaag atgttgcgat attgcaagat atattcaatc attcagcacc aagtataaca
     5281 ttgaagtata ttggaataaa tgatgatata aaagataata ccatagaaaa cttttattta
     5341 taaagtagct aaaatgctgc tttttattta tttaaaatta atcataaagg attttgtaaa
     5401 aataatactt tagcaatact attgtaatat attaccaatt agtatattat taaagtatta
     5461 tttatgtatg ataatataaa agtattacta aagtattata ggggtgatga tatggataga
     5521 acggactttg ataagttaga agtacaggat caagtaattt atataaataa acaattaggt
     5581 gaaggatcta cacttagaga tattgcaagt aatttaaata tagcacgtag cacattaaga
     5641 gatagattta aaaagatagg atatatttat aataaaaaat taaatacata ttcaaagact
     5701 aataatgagt ataacaaaaa taatactaat gtattatata aagaacctgt aaagaaacaa
     5761 aatacacttg aaattgaatc atacaaaagt aatactattg taagtaataa ggaattacag
     5821 agcataaaag aagttaataa tttaaaaaaa gaagtattcg aattgataaa taataaagat
     5881 ataatacttg aaatgattaa ggattacaaa agtaatacta aaataataga tatacctcag
     5941 ttagatataa ataatttacc agtagaaatg caaaaggata taacaactaa aagtataaaa
     6001 gtatataagc ctatatataa tttatttaat aaattgtgtg aagaatattc tagtataaaa
     6061 aaacaagatc taattagttt agcattatat gaattttata taagatataa aaaataattt
     6121 aattttatat aaaatgttga ttttactagc ttaattagaa tattaaatta tatttatata
     6181 ttaaaattaa atataatcat gtattttttc atgaaaaaat aatacaatat agtacattgt
     6241 attactttat attattttgt attacattgt attatttaaa aataatttat tttttataaa
     6301 taaaattgtt gaatgttgga aggaaaagag gtaaaataaa gacaagtttt tttaaaaata
     6361 aaataaaaaa gtccttcaac tcttatatat cgtacgggaa tacgttatat aagccaattc
     6421 aattatgtac gggaatacat aaaagaacgt tagaaagacc ttataattta ctattcaatt
     6481 atagaataga ttatacaaaa ttattaagag aatttcaagc attttttagt atgaacgtac
     6541 taagaagtgc ttttttaatg tttaaataaa aatagacaag ccttattaat caatatataa
     6601 gtgattagag gtggttatat gaaaagagtg aaaagctgta gaaagtgtga attttataat
     6661 gaagatgaag agtttaattg tacaaacttt aaaatggtaa ttcttgattt taataatgca
     6721 cgtaaatgta tttattatca agagcgtatg ggaaggagaa agcgttgtaa gacctgtatg
     6781 tatttaagta ccacatataa acaagtataa gtatgtatgt gtaaagacag gaaaaatacg
     6841 atcatatacg cagctagtgc actgtaacag atataaaaaa ataaatagta gttagtttat
     6901 tagggagaca aagttaaatc gtgttgagga gtatatcacg taaaaacaag cgaccgacta
     6961 atcaatcggt gctgttgccg ttagagggta ggaaaacttc tcagaagaac atatgtaaaa
     7021 ttttaacatc ggtttgtgac tgtcctagtt gggggcgtag gtgaaggatt gtgataatcc
     7081 tagttggtaa tactagacct gagcgacttt gaacctatga cgttgtaatg acgtggatat
     7141 acggatacct ttgattccta tacggattaa aagaagtaaa aagtatattc ccttgtgctc
     7201 gaatataatc tatattcgag cacaaggggg ggaaagccgt tttccttatc aagcctacca
     7261 gattaaaatt aagatcgttt aaagtcaata tataaattaa aaatttttaa tttaacaggc
     7321 ttgaaggggt aagagtatag gtagtttata ttaaatataa agtttaaaat tatatttagc
     7381 atttaaatac taaaggtgtt aaaaatataa gaagagataa caaagttgat gatagatctt
     7441 acggaagtag aataagaata actattattt tgccataata gttattctta tttaatttgg
     7501 ttgaaattaa ataattgata aagtaaaata gtactagtta agtgtgagtg cgcacagcac
     7561 agcagcggca agctccccga atggatagcc attaggctcc cattttattc agagcttgtg
     7621 aggggatacc ccttcaaacc cctatttttt aacattggtt tttaaaccaa tgtatttata
     7681 atttagttat taaggaggtc aaaatgaata aagaaaaagc tgaagagata atagaaagtg
     7741 tacaaggaaa tataaagcat tctgatatga tactaacaga cgatgaaaga gctcttttgg
     7801 aggaatatat attagggaat attacaagag aagaatatat tgaaaaatca ctagaagatg
     7861 tacagaagga taatattaga tatggcatta aaggggaaaa gatattagat agtactatta
     7921 atttaagtga aaattgtaaa gttaatagaa aaaggaataa acaaatagtt ataagagcta
     7981 caaggaaaga gtttaacact ataaaaaata aagttaaaaa atctaagtta agtcaaaatg
     8041 aatatctttt aaaatgtgca ttagataaaa ggatagtagt agtagatgga ttgaaagatt
     8101 tgaatgtaga gctaaaaagg ataggtaata atcttaatca gctaattaaa tcggtacatg
     8161 aaggtaaggc taattgttca aaggaactat tagaaataaa tgaggagatg aaagaggtat
     8221 ggcagttatt aaggcagtta actccaaaag ctctttagat ggaattatta agtatgttac
     8281 tagggaagag aagacagaag aaagattaat tactgggaag gattgtagtc cttcaaatgt
     8341 gcttgaagaa atgaaagtaa ctaaagaaat atttaataaa actacaggaa ggcagtataa
     8401 acattttatt caaagttttg atccaaatga taatttagat tatatgaaag ctaataaaat
     8461 aggcttagaa tgggcagaaa aaatttttaa aggtttcgaa gttttaataa gtactcataa
     8521 ggataaaggg catatacata atcattttgt tgttaattct gtaagttttg aagatggtag
     8581 aaaacttaga tatagcaata aagaattaca aaattttaaa aatgtaaatg accgtatatg
     8641 tgaaagagaa ggattaaata tagtaagaga agtaagcaaa gagataacaa gctttaatca
     8701 taataaatat aaagtaatag aaaaggcatt taagggcatg ggtgaaagct atcttttaaa
     8761 tacaggtctt gaagtaagta attcattaaa ggtatcaaaa acaaaagaag aatttataaa
     8821 atctatggag gaaaagggtt ataaagttaa ctggaaggat acaagaaagt atataacttt
     8881 tacaactcct gaaggtagaa aaataagaaa ttcaaattta caaaatacac ttaaaaatga
     8941 taaatttacc aaggagggca tggaaaatga acttcgatac aatagataaa aagaaagaga
     9001 atgtaatttt agagaatcag gcatttcaaa aactccagga gataaattta atgcaaaaaa
     9061 tgggactgga gaacagtttg ctgaaagagt ccttggctca atcacacgag aaattgcagg
     9121 aattgaagta agagcaaaag gagagcctag tgaaaataaa agagatacaa gatcaaacaa
     9181 cagagaagat aaaagaattg aagacaagca acgaactatt aaaagagagc atagaggaaa
     9241 aactagagat cttggtagat aaattaaacg aaatacttaa aggattgtcc ataaaattag
     9301 ataaggttta taaggtttat atagaacgta tgggaacaga aacagaaaaa aagatacaag
     9361 ccctcaatga gttgcagaaa gaggctgaaa atcgatgtga gagctattat aatagaaaaa
     9421 caataatagc ttatttaatc tatataaatt tagcaataac tcctatatta ttttttataa
     9481 taatatatat tcagtttttt aagaaataaa cggacggtga ggcattggta tatcctggtt
     9541 atagcagagt taaaatagag ttaatttata gtaaaaatgg agtcaaatag aactcatatg
     9601 gagttaaaat agagtaaaaa cagagttaaa aaaagtctta aaatgatatc acttttttaa
     9661 gattttttta gatagaaata tagttagcac agttaactta ccacttacta tttagtaagt
     9721 ggtatcatat ttcccttatg ctctttttaa gttacttttc tgagaaagta ttttttatgc
     9781 aacatcatgt aaaaaaaaat gggaacactt taccatatta tggagtatat gtcaattcag
     9841 aaaaaaggaa taattgtcca aattatagct tatattgtaa taaatataaa tatattttat
     9901 tcagttggat ttatattaat aatgtataat ttgataaatt ataccaaatg atataatatt
     9961 ttactaaaat caatcaaaaa ttatatttaa ataacaagta tagactaaag aatttctaaa
    10021 aggagtaaag atatgtatcc acaattaaca gacaactctt ttgtaaagca aacaccagat
    10081 aaagaagcgc atgttttttc gttcttcatt aatgagatgc gtagttatgt gagtataaat
    10141 gaaagtgcga gtagtatttt aggcttatgt aatggaatgc attcaataga agatatcata
    10201 tctatcctaa gtaataaata tgaagaagat cccaatgtgg taaaaaaaaa tgtacaaaca
    10261 tttttagacc ctttcattaa gaatagtatt gtaagggata ataaggttga attttcaaat
    10321 agaaatattg ttaatggaag tttggaagtt tattatcccc atgcactttg ttgggagatt
    10381 accgattatt gtccgttgaa ttgtaggcat tgttatttgc ctgaaaaaaa taatagcata
    10441 ctttctagag ataatatcga taatgttcta gaaataatag attctgcagg tatacagcag
    10501 gttcaagtga caggaggaga agcgttaacg catcctgaat tggaatatat aatagatagt
    10561 cttattaata gaggtataat tacatctata tccacaagtg gatttaattt tactaatgat
    10621 atgtttaaat atttagtgaa attaaaagaa gtgaaaggaa gtaagttgcg tgtaagtctt
    10681 gatggcgata aaaatataca caattatatt cgcaaaaatg aatatgcata taacaatgca
    10741 atagaattca taaaaaccgc agttaaaaat ggtatcattt gtcaagtgga gactagtgta
    10801 ataaaccaaa gcaaacaaga tcttgaagac ttagttgttc tggtaaaaga attaggtgtt
    10861 agttccattg aaattgcaag gataagcgat cagggaaatg ctcgtaaaaa taacctggag
    10921 ttagtgtgga gtccaaaaga atttgatgat tttttatatc aattaaattc caagtatgct
    10981 aatgaaacat ttaaaataag gttacctaaa gaagaaaaaa acaaaaattg tggtgcagga
    11041 tataaaataa ttagaataaa accaaatttt gatgttacac catgcccaat gctagaattc
    11101 agattaggaa atctgcataa agatactatg tttcaaataa tgtcgaaatg cggcaatata
    11161 tttcatgaat ttgaagctcc ccaaaataaa ttttgtagtg aatgtgaaaa caaggatact
    11221 tgtgatcatt gcattgcatc aggttttaac tctaaagata aagttaaaga ctgtcgttgg
    11281 tttagaaata ttgaatattg tctaaagcct tttttagaca ggtaaaaaac ataatatata
    11341 gtatatttta aaagaaataa tttttatcta tcttgcataa caatttatta aaaaaaatat
    11401 atatacgtaa atgctctgaa cactttctgg ttaccagaaa ggatgaaata gataaatttt
    11461 ttacattcag agaaagaata ttttgtttta tagaaacatt ctttaaattt tttaatgggg
    11521 aggtgagaaa atggaaaagc ctaaaattac aaatgctaat atggtagctt gtagtggaaa
    11581 cccttacgct gcaattgcta tgttgggttt agcatgtgga gcagactttg catattgcca
    11641 gatgccgtca gtatcggatc tatggggttc aggaacagca aaagcacttt aattataata
    11701 gcatggatga taaataaaca tccatgctat tatattatta aagatagaat gatcctttaa
    11761 aataaagaaa ttctttataa caggggaaag agtacagtta gatataaaga tgttaatatt
    11821 actacaagta actcactaac attgagtgat agtatttttt aattatggtt tttgcctaat
    11881 ttttattaga aggtggaata tgtaatgaat tataagcaga gtgtgtatac aatacagtta
    11941 aaatatatta aagatgattt tgaatatata gttgattcat ttagtggcga aagggaagaa
    12001 actataagaa atatcaaact aaatacctgt aaaaatttat ttgatgatgt tcaattaaat
    12061 ataagtacac cttatttaat aaatttgaaa aaatctttac gatatattaa gaaagattta
    12121 gaaaaacaag atattaatct ttctattttt atgaatttac ataatgaaag agtgctgatt
    12181 gacaatgagg aagaagataa tcgttcatat ggattccttc gattgatttg taaagataat
    12241 gataataata tgcatataga tgatatccca attttatcat gtaatcctat tgatctagaa
    12301 gataagatta attactatgc aaaaaaatat ataagtatga aaaatcttca tgatataaga
    12361 gaacaggtaa gttttgaatc tatacctcat attttatcac ctaaagctgc tggttatttt
    12421 atacatgaaa tagtaggaca tactttagaa agtgattttt attcatacta caaggataaa
    12481 tatgaaaata tgaaaatttc taaaaaacta acagttactg attctataaa tggttataat
    12541 cgattaatag gccttcaagg ttatgatgat gttggaacta aaatagaatc attaacatta
    12601 attaataaag gaaaaattca aaatatgcta gcaattaaga aagaagatag cttcgatcat
    12661 aagctatatg gtgtagcaag aagagcatct tacaaattcg aggtacttcc tagaatgagg
    12721 agcacataca ttcacccttt tgatgatatg gatcaacaag atatattaga taaatatgaa
    12781 aatgcaatat ttgtgaatga aattttttta ggtggagttg atcataaatc aggtaaatat
    12841 aatttaaatg gaaatggatt tattgtaaaa aatggagagc tacaaaattt tattggagat
    12901 ttaagaataa gtggggatat attaaaggat atttcttcga ttgactatat aggcaaagat
    12961 tttgatatgt ttggtaacta ttgtgaaaaa tttggtcaat ttgtacgtgt tggaagtggc
    13021 ggccccacta ttagtatatc atctttaaat gcaagggggg tattatatgg aagaagataa
    13081 gcgtatagaa aaaagattat tatcaaaagg aatcatggag tataagatta ttcgtaccat
    13141 attaagaggt atgaaatata aagagtattt tgggagtgta tctattgaag atttgtcaga
    13201 tgataaaata ttggttctgt ttaaaaccga agaaggaatt gcgaaattta cggtttcatc
    13261 ttttcaatca gacaatataa tagataggat tattgaaaca agcatgaaaa accaaatgaa
    13321 gatgtcatta caatggcatg atgataattt tagtgatgta aaaatagaac aaaatgaaaa
    13381 ttataatcgt ttttataaat ttaatagcaa cgactacata atgtggataa aaaaagaaat
    13441 agataatatt tcgaaaaaaa taaaattcac atttaataca atatatacaa taaatgtgaa
    13501 taaatattgt ttacgtacaa ataaagatta tattgaacaa tataatacta gctcagagtt
    13561 tctatgcata gaaaataaaa catttaaaag gagatctaag ttaagtaata gatttttaaa
    13621 agacgatata gcactctcaa ttattaaaca attaaataat gatgatattc caagaaataa
    13681 tataaatttg aactctaaac aacgtatact tttaaaggca aaagggttat cagatttttt
    13741 aaatgtctat atttctttat attatgccaa ttatatatat tccaatcaat catttataaa
    13801 aacaaattat attggaaaac aaatttcaaa aagtaacttt gatctaattg ctattccata
    13861 taacggaatt aaatttgata gtgaagggtc tagaatcttt aaaaagctga ttgtcggttc
    13921 tggaaagtta attaatttgt taagtaataa cagtttttct gaatacttta atattaatag
    13981 ttttggtaat gcaagtttag atactcataa tactgtttca catcaacgat taatttttac
    14041 atgtaaaaat tcagaaagaa ttgtttctaa atcagtagat ttaataattc atcaatttga
    14101 aaatgcatat atagattttg aagataatga agtatttagg ggaaatgcta tttgcagtga
    14161 taaatcgggt tacttccgta ctacaattag ttttaatcta aaatatattt ttaataatat
    14221 atatcctatt ggtaataaaa gtacttggat taataatgta tattgccaag acgttataat
    14281 attaagataa agataaaatt taatggattt cttaagtatt aaataaaaat ttaaattaga
    14341 tagatttatg tagtatataa tggttttatt gtattataaa tatacataat tcaggaagga
    14401 gattctaggt gtgggtaagt taaggagttt attaaaatta aagccatttt tacaaaagta
    14461 taaactactt ttgttttttg ctttaatagg aataatatta ggttcaattg ttgctattcc
    14521 agttccatat ataataggaa aaataatgga tgatgtactt ataggtagta aaagttttaa
    14581 tgaattttat ttctatattg gtataataac aatattatat gttttgaaat attttatttc
    14641 tattacatca aattatttat cttctaaatt taacaatttc atgtccaatg atttgagatt
    14701 tatactaata gataaagtta tggatttgcc tatggattat ttggcaaatg ttgaaaaggg
    14761 atatctacaa ggtagaatat ctgaatgtga ctcaattaca gctatttttt ctggaactat
    14821 cataagtata ttattgagta cggttaatgc tgtattatca gtatcaacta tgtttgtaat
    14881 aaattacaag ttggctatag ctgttcttat tttggtacca ttttttttca tcttagctaa
    14941 attttcaaac catgcactta caaaaaatac aaaaaaaatg ttagaggata gtgcgatttt
    15001 aaatgcagaa tgttttgaaa taattaatgg agttgaagat ataaaaatac ttaatggtaa
    15061 ggcatatagt ttggggaaat tcaaaaaaaa gttagatcaa tttataaaaa ttacattaaa
    15121 acaaaataaa actatgttat tattatcgca aaatgttgta ggagttaacg atgttggaac
    15181 acttttaata ttacttattg caggaaattt aattattaaa ggggaattta ctgtaggttt
    15241 gtatacaaca ttttcattat attcgagtaa aattttttcg agtactcaat tacttgcaaa
    15301 cataggacca tccttaaagc aggcatgttt aagtatagaa agattatatg aacttataga
    15361 tatggatgat gaaaataaag gtaaaaataa acatttaaac aaaaaaatag aatccataaa
    15421 gttagaaaac gtaactttta aatataaaaa tagtattaaa aatgtcttag attccttaaa
    15481 ttttgaaatt aataaaggtg aaaaagtact tattagtggt gaaaatggga caggaaaatc
    15541 aacattaata aagttactag ttggtctata tgaacctaca gaaggaagaa tattatataa
    15601 taatttagat ttagctacaa ttaacaatga aagtttaaga tcgcggatag gtattgtttc
    15661 acaaaatatg tttcttttta aaggaactgt attagataat atattatatg ggcaaaatca
    15721 aaaaaagcgt aaagatgttg aaaaacttat aattaaattg aatctagaaa attacataag
    15781 taggctacct gaaggcttag attctaaaat aattcaaaat aataatggaa tttcaggcgg
    15841 ccaaactcaa gttatagctt ttataagagc agtactttca aataaagata taataatttt
    15901 ggatgagcct atatcaaatg tagatgctga aactagaaat ataattttaa atattctaaa
    15961 agaaagcaaa tttgatggaa tattaattat tatttctcat tttacaaaag gaatggagtt
    16021 cataaataaa acgattaaag ttggtaaaaa ataattacaa tgtaaaagta ttggcaaagt
    16081 ctttatccga gattatatat aaaaatcaga taaagagtat ataatttatt ttaaaagaaa
    16141 tcctagtaac tctaataaaa actacctaaa attaaaaaat ttgtacttga ggaagttctt
    16201 tattagggtt acttttgata actcatgtat aagtatgatt tatattaatt tataaaattt
    16261 aaatttcaaa gcaacatatg agtaaccatt ttgaggatat tgacctcaat accttagttc
    16321 aggctagtct gttaaaatca aaat
//
