LOCUS       NC_008263              12397 bp    DNA     circular BCT 05-DEC-2007
DEFINITION  Clostridium perfringens SM101 plasmid 1, complete sequence.
ACCESSION   NC_008263
VERSION     NC_008263.1  GI:110803998
KEYWORDS    .
SOURCE      Clostridium perfringens SM101
  ORGANISM  Clostridium perfringens SM101
            Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
            Clostridium.
REFERENCE   1  (bases 1 to 12397)
  AUTHORS   Myers,G.S., Rasko,D.A., Cheung,J.K., Ravel,J., Seshadri,R.,
            DeBoy,R.T., Ren,Q., Varga,J., Awad,M.M., Brinkac,L.M.,
            Daugherty,S.C., Haft,D.H., Dodson,R.J., Madupu,R., Nelson,W.C.,
            Rosovitz,M.J., Sullivan,S.A., Khouri,H., Dimitrov,G.I.,
            Watkins,K.L., Mulligan,S., Benton,J., Radune,D., Fisher,D.J.,
            Atkins,H.S., Hiscox,T., Jost,B.H., Billington,S.J., Songer,J.G.,
            McClane,B.A., Titball,R.W., Rood,J.I., Melville,S.B. and
            Paulsen,I.T.
  TITLE     Skewed genomic variability in strains of the toxigenic bacterial
            pathogen, Clostridium perfringens
  JOURNAL   Genome Res. 16 (8), 1031-1040 (2006)
   PUBMED   16825665
REFERENCE   2  (bases 1 to 12397)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUL-2006) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 12397)
  AUTHORS   Myers,G.S., Rasko,D.A., Cheung,J.K., Ravel,J., Seshadri,R.,
            DeBoy,R.T., Ren,Q., Varga,J., Awad,M.M., Brinkac,L.M.,
            Daugherty,S.C., Haft,D.H., Dodson,R.J., Madupu,R., Nelson,W.C.,
            Rosovitz,M., Sullivan,S.A., Khouri,H.M., Dimitrov,G., Watkins,K.L.,
            Mulligan,S., Benton,J.L., Fisher,D.J., Atkins,H.S., Hiscox,T.,
            Jost,H., Billington,S.J., Songer,J.G., McClane,B.A., Titball,R.W.,
            Rood,J.I., Melville,S. and Paulsen,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2006) The Institute for Genomic Research, 9712
            Medical Center Dr, Rockville, MD 20850, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CP000313.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..12397
                     /organism="Clostridium perfringens SM101"
                     /mol_type="genomic DNA"
                     /strain="SM101"
                     /db_xref="taxon:289380"
                     /plasmid="1"
     gene            1237..1677
                     /locus_tag="CPR_A0001"
                     /db_xref="GeneID:4206632"
     CDS             1237..1677
                     /locus_tag="CPR_A0001"
                     /note="identified by similarity to PIR:G97083"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_699910.1"
                     /db_xref="GI:110804002"
                     /db_xref="GeneID:4206632"
                     /translation="MFNLYNEFLKYEYNELQELFKMARSKEEQDFYMALCNFKLQKEQ
                     KKVIGNDFEMELTLNEILNWVKSERLRLNLPDSKTFYFSNEKSNDNYDLKIFKCFSSD
                     KDIKSLKDIIRAEIESVNNEYSICKIIIDVRFGSLTFYFKNKKI"
     gene            2060..2632
                     /gene="res"
                     /locus_tag="CPR_A0002"
                     /db_xref="GeneID:4206638"
     CDS             2060..2632
                     /gene="res"
                     /locus_tag="CPR_A0002"
                     /note="identified by similarity to SP:P07945; match to
                     protein family HMM PF00239; match to protein family HMM
                     PF02796"
                     /codon_start=1
                     /transl_table=11
                     /product="resolvase"
                     /protein_id="YP_699911.1"
                     /db_xref="GI:110804008"
                     /db_xref="GeneID:4206638"
                     /translation="MLVGYARVSTEDQNLDRQIDLLIDYGVDKRNIYQEKISGTKTHR
                     EQLDKMIDELQEGDTVIIADLTRISRSTKDLLDIIDRIKAKGASIKSIKDTWLDTSSD
                     NPYNSFLLTVMSGLSQLERDLISQRTKEGLKSAKARGRNGGRPSKRNDKSDTVGLLYK
                     EGYKIVDIVKQTGLSRATVYRVLKDLGLKE"
     gene            complement(2714..3745)
                     /locus_tag="CPR_A0003"
                     /db_xref="GeneID:4206635"
     CDS             complement(2714..3745)
                     /locus_tag="CPR_A0003"
                     /EC_number="3.5.1.28"
                     /note="identified by match to protein family HMM PF01520"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase domain
                     protein"
                     /protein_id="YP_699912.1"
                     /db_xref="GI:110804005"
                     /db_xref="GeneID:4206635"
                     /translation="MKIAIRGGHNFLSKGACGLIDETTENRKVYKSVIKNLIENNFEV
                     LDVTPGDCDVNTDLKFGVEKANNFNADLFISIHFDKCYEKFDGPLGTGTWVCEKGGKA
                     EVYAKNIVDTVSEGTSLKNRGVKTNAKLYELNKTIMPAVIVEVCFCESKVDVDIYKEK
                     GSELIGYLIAKGICKSVNKEISEDLPQNNKEQENINLQDNKTFKTNATAKVALDPRDN
                     PSNNYRDLGEIFANERIKILPEICDLKTFLPATYWKDSENKESTPIWINSKQSVLKID
                     TNATVINVLTELDARYDPSPNSNRMGYVKNSERLFVHKVENNYALATYLAGEGYKTAW
                     FTSKYIKLD"
     gene            3983..4549
                     /gene="uviA"
                     /locus_tag="CPR_A0004"
                     /db_xref="GeneID:4206634"
     CDS             3983..4549
                     /gene="uviA"
                     /locus_tag="CPR_A0004"
                     /note="identified by match to protein family HMM PF04545"
                     /codon_start=1
                     /transl_table=11
                     /product="uviA protein"
                     /protein_id="YP_699913.1"
                     /db_xref="GI:110804004"
                     /db_xref="GeneID:4206634"
                     /translation="MQELYEKIKLCKLGNKEALQEVVNIFEKTIMKELFKFKKENSTI
                     FMNEYDFQDKKSEITLNVLNAIKNMPIESFEYKTDYSVKKYIRKTILNKLNEIKTKEF
                     NKTENEYKYEFDFSFFKSSDFNEPNTDIFVHDLIDKLSEKERKVIKYKYIYGKSDVEI
                     GELLNCSRQYVNKIKNRALKNIKKFLDD"
     gene            4600..4797
                     /locus_tag="CPR_A0005"
                     /db_xref="GeneID:4206630"
     CDS             4600..4797
                     /locus_tag="CPR_A0005"
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-related protein"
                     /protein_id="YP_699914.1"
                     /db_xref="GI:110804000"
                     /db_xref="GeneID:4206630"
                     /translation="MDSEMFKLIATQGAFALLFSYLLFYVLKENSKREENYQSIIKEL
                     TELLPSIKNDVEDIKNKLNSN"
     gene            4894..8097
                     /gene="bcn"
                     /locus_tag="CPR_A0006"
                     /db_xref="GeneID:4206633"
     CDS             4894..8097
                     /gene="bcn"
                     /locus_tag="CPR_A0006"
                     /note="identified by match to protein family HMM PF00018;
                     match to protein family HMM PF00246; match to protein
                     family HMM PF06347"
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin"
                     /protein_id="YP_699915.1"
                     /db_xref="GI:110804003"
                     /db_xref="GeneID:4206633"
                     /translation="MILKIKSEVLKMIMRFIPSVNPGDSVGSKPTFPVNAQVKGDFLY
                     LRDANGNQIAGRSVSDGDEITVLKVDHTKQLALVQYPAGTIYRQGYVTNATSIIKYKN
                     EYNWLNGSTPETVYDVDKKTQIGSLDPREKATILYKVDGMTALVYDTSKGKMTKSGLV
                     HYAGSGGSTGGGDINGIAPGGEVPGGFTYPNNAQVVGDDLYLRDANGNQISGRVVSNG
                     DKITVLDVGYTKQLALVQYPAGSVVRQGYVTNATNLIRYFKQGEWLNGSTTEPVLDEN
                     GGSLGSLSPYEAATPLYKKNGMTHVVYDTSKGPNTKSGYVKFEGLPELPDTGIQIPST
                     SHSQATVEVYGTSGKGRPLKVYKIGSGSKVLFAGFALHGWEDNWSNDGLALVNIANSL
                     IEKIGDYKAQNGLHGWTVYIAPCMNPDGVVVKGTHNGPGRCAVTTRVDMNRCFPYKFS
                     PQYISRNYTGPNPLGAPEAVALKNLVERINVSSSEMVVLDFHGWMNFTQGNAELGSYF
                     GNQFGFGHKNLYSSGFFSSWATTLRNTKAVLIEYPTNTYSYNDVINKNYIGKTFNGII
                     NILKNNPNGGDVDNGGSDSSEIPYNANGEVINVEPTSALNVRSGPGTTYRAIGTLKLG
                     NRVTILAKTKPAGETKDWYKISFNYGSGYIRSDFVKLDSSEINYNAVGEIINVSSFLN
                     VRSGPGTNFEMLGKLYKGDVVLIVSKNGDWYKIRYGTTFGYIHKDYVYINKENDNFVE
                     KKVQIGAVEINKVKTIDGIVFANINQMLKGFCNNNGYTKAPSGDIIVTVHNFHKKMDV
                     SKTLPISKCKLINGDYYYNLNEFISILGYDEFVQNISDYSDVIYKYVYIGMDDETQFT
                     IHEALDALGFIPVVGDVIDGVNAIMYALEKDYLNAALSLGAIIPVIGSPFFKGGKYGF
                     KIMSGFSKVANKSKKFVKKLDITEGRYVYRAIHDADLQRIKDGLGLQAKNPNGTWSLE
                     EHIVRGSNSESWKNDRFISTSLDLEISRIFNSSKNLGIIKIDLEKVPKELIYKSYKEF
                     PLYDINGHRSLAYEFSVWQQEISILKEIPRDAFEFIE"
     gene            8113..8400
                     /locus_tag="CPR_A0007"
                     /db_xref="GeneID:4206631"
     CDS             8113..8400
                     /locus_tag="CPR_A0007"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_699916.1"
                     /db_xref="GI:110804001"
                     /db_xref="GeneID:4206631"
                     /translation="MRNIRYVLTPEAYGSNGEFIDKIGTLGDLVVDTGMLLRPQFDKT
                     IPNIKVLNSLFREGWYPRSAEWEPFEIDSDEYNELVEYLLSLPLNKPYKLE"
     gene            8525..9076
                     /locus_tag="CPR_A0008"
                     /db_xref="GeneID:4206637"
     CDS             8525..9076
                     /locus_tag="CPR_A0008"
                     /note="identified by match to protein family HMM
                     TIGR02464"
                     /codon_start=1
                     /transl_table=11
                     /product="protein T24A6.7"
                     /protein_id="YP_699917.1"
                     /db_xref="GI:110804007"
                     /db_xref="GeneID:4206637"
                     /translation="MKYTLELICNEFNKNKIIDFLFFWGHTENNKKEVTKACLSQWYY
                     SYFKIDGIAYCCAEQYMMAEKARLFKDFNVLDKILAASKQSEIKRLGRMVKNFNENIW
                     NERKIDIVVKGNIEKFSQNEELKKFLLNTKNKIIVEASPYDSIWGVGLSVNNENITNP
                     NKWSGKNLLGFALMEVRDFLNEI"
     gene            10874..11167
                     /locus_tag="CPR_A0009"
                     /db_xref="GeneID:4206629"
     CDS             10874..11167
                     /locus_tag="CPR_A0009"
                     /note="identified by match to protein family HMM PF01402"
                     /codon_start=1
                     /transl_table=11
                     /product="Ribbon-helix-helix protein, copG family domain
                     protein"
                     /protein_id="YP_699918.1"
                     /db_xref="GI:110803999"
                     /db_xref="GeneID:4206629"
                     /translation="MATKVVKDDIIRVRVTKEHKEKLKEIAKKKNITISEIISVATEN
                     EIKKYEEKEKNYKKICERSVATEEKIQEIKFNLEKRKLKNKKNIFKNIFNLRR"
     gene            11173..11433
                     /gene="orf14"
                     /locus_tag="CPR_A0010"
                     /db_xref="GeneID:4206636"
     CDS             11173..11433
                     /gene="orf14"
                     /locus_tag="CPR_A0010"
                     /note="identified by match to protein family HMM PF03681"
                     /codon_start=1
                     /transl_table=11
                     /product="ORF17"
                     /protein_id="YP_699919.1"
                     /db_xref="GI:110804006"
                     /db_xref="GeneID:4206636"
                     /translation="MKKIYSYPSILTKENDGITVTFPNFKGCISCGYTFEEAIKNGKQ
                     ALGLHINGLIEDNEVLSDPKEIKNIKLYENQKIEFIEVEIEE"
ORIGIN      
        1 taaatatgag gttttagaat ggattggagt tatttttatg agtaaaaaga aaaatagaaa
       61 tattaacgga cagattacat atgccataaa caaatgcttt aaagaaggaa tggataaaag
      121 agcatataag atccaagagg gaagatccat gggcgataaa gtttttagtt atgcggaaaa
      181 atatagactt aaagatatgg cgaaatcttt acaaaaattt ttaaaggaca atggaagaga
      241 tgttaagtat gtgaaggata tacaatcgga agatattcaa ggctacttag aaagtgcaaa
      301 ggcgagaggc tgcacacaaa atacaataga tacatatgcg aatagcttat ttaaaattca
      361 agaggctata aatgccacat atggcattaa aacaaattgg aggagtgaaa tatctattcc
      421 agtagctgaa aaggctcaga gtggcgatag aggagcaaat agtgttataa caagagatga
      481 ttataataaa atattagatt atgcagaaaa aaatattagt gaaagcggat atgctataag
      541 attacaggac tttttagggg ttagagttga ggaagtggct cgcataagta gagataatat
      601 aaacttagag gagaaaacta taaaatttac taatacaaaa gggggaagag aacttacaag
      661 agatattcca gatgatagaa taaatcttgt taaggaagta ctagaaaaaa attaccatga
      721 agataggctg ctgagtatac aaggagattc tataaacaga tatttaaata gaattgaaga
      781 taaattaggt atagaaagac acagtaatca cgatattagg cgtttaatag cacaggagaa
      841 gtatgatagt tatagagaat caggattgag tataaaagat gcagctaata aaacaagtac
      901 ttggttaagt catggagata atagaaatga gctgcttgaa aagagctata taaaattaaa
      961 ataaaatttt agatttataa atattaactt gaaatttatt tattgattaa aagatgagtt
     1021 taatttaaaa tttagattaa tactgtaatt ttgtttacta aaaattaaag aactagtatt
     1081 tacttttata tttttaaatt gcaaaaatta attgtcaaaa tactaaaaag aagatgaaat
     1141 tttatattta tttctgaagt tccttatttt gaggacattg aaaaaatata ggttttatct
     1201 ttttttatat taattaaagt tagggagtta aatattatgt ttaatttata taatgaattt
     1261 ttaaaatatg aatacaatga attacaagag ctgtttaaaa tggctagaag taaagaagaa
     1321 caggacttct atatggcatt atgtaacttt aaattacaga aagaacaaaa gaaagttatt
     1381 ggaaatgatt ttgaaatgga gttaacatta aatgaaatat taaattgggt taagagtgaa
     1441 aggcttagat taaatctacc agatagtaag actttttatt tttcaaatga aaaaagtaat
     1501 gataattatg atcttaaaat atttaaatgt tttagttctg ataaagatat taaaagttta
     1561 aaggatataa taagagctga aatagaaagt gttaataatg aatatagtat ttgtaaaata
     1621 ataatagatg taagatttgg atcattaact ttttacttta agaataaaaa aatataaaat
     1681 ttattagtaa attttatata actataagta gtttaaataa taagtttatt ataaataatt
     1741 tataaaatca gtatcaaaaa cgagtgtttt tgatacgttt tttttaataa gtaaacaagc
     1801 catttaataa gtttaaaaat gtatcaaaaa aggtatcata atctattttt attatgatac
     1861 ctttatgata caatataatt aatagatatt atagaaaatg gagattaatg atatgtataa
     1921 attaacttat agatatggca atagaaaaag aagttataca aaaatattta atagcaaaag
     1981 tgatatggag agatatatag aatccgtaaa ggataaaaat ttaatagttc ttgatataga
     2041 attgataaat gaaaaaaaga tgttagtagg atatgcaaga gttagtacag aggaccagaa
     2101 cctagataga caaatagatt tgttaattga ttatggtgtt gataagagaa atatatatca
     2161 agagaagata agtggtacta agactcatag agagcagcta gataagatga tagacgagct
     2221 gcaagaagga gatacggtta taatagctga tttaactaga atatcaagaa gtacaaaaga
     2281 tttattggat attatagata gaataaaggc taaaggagct agtataaaga gtataaaaga
     2341 tacctggtta gatacttcaa gtgataatcc atataatagc tttttattaa ctgttatgag
     2401 tggattaagt caattagaaa gggacttaat aagtcaaagg actaaagaag gcttaaaaag
     2461 cgcaaaagct aggggaagga atggaggaag gccttctaaa agaaatgata aatctgatac
     2521 agtaggtttg ctttataaag aaggttataa gatagtggat atagtaaaac aaacgggatt
     2581 aagtagagca actgtatata gagttctaaa ggatttagga ttaaaagaat aatagtttat
     2641 atggaaaaaa gactataaaa aagtttttat tactttttta tagtcttctt tatttctctt
     2701 tgatgtactt ttattaatca agttttatat atttagatgt aaaccatgca gttttatatc
     2761 cttctcctgc taaataagta gctaatgcat aattattttc aactttatgg acaaaaagtc
     2821 tttcactatt ttttacatag cccattctat ttgaattagg tgaaggatca tatctagcat
     2881 ctaattcagt taaaacatta attacagtag cattagtatc aatttttaat actgattgct
     2941 tggaattaat ccatataggt gtagattctt tattttccga atccttccaa taagttgcag
     3001 gtaaaaatgt ttttaaatca catatttcag gcagaatttt tattctttca tttgcaaaaa
     3061 tttctcctaa atctctatag ttattactag gattatccct aggatctaaa gcaacttttg
     3121 cagttgcatt agttttaaag gttttattat cttgtaaatt aatattttct tgttctttat
     3181 tattttgagg taaatcttca ctaatttctt tatttacaga cttacaaatt cctttagcta
     3241 ttaaataacc tattaattca gagccttttt ctttataaat atcgacatca actttagatt
     3301 cgcaaaaaca aacttcaact attactgctg gcattattgt tttatttaat tcataaagtt
     3361 tagcgttagt tttaacaccc ctatttttta gagaagttcc ttcagaaact gtatctacta
     3421 tattttttgc atatacttct gcttttcctc ccttttcaca aacccaagtt cctgtaccta
     3481 aagggccatc aaatttctca taacacttat caaagtgtat agaaataaat aaatctgcat
     3541 taaaattatt agctttttct actccaaatt ttaagtctgt atttacatca cagtcacctg
     3601 gagtaacatc taaaacttca aaattatttt caattaagtt tttaattaca gacttataaa
     3661 cctttctatt ttcagtagtt tcatctatta atccacaagc tccctttgat aaaaaattgt
     3721 gaccaccacg tatagctatt ttcatatttt tcttcctttc cttttaaaaa ttttatttaa
     3781 ataagcttat atatttaaaa gattgataga cttttgtttt gtaaacataa aaataaaata
     3841 tattgggtgt tttgaaacaa aaatgtatat tttgtaaaat tatagaacgg aacgttacgt
     3901 ttttttaaaa gcttattttg gagatttaca cttttcctca tttttctctt taaaaaataa
     3961 aagagattat gaggagaatt ttatgcaaga attatacgaa aagataaagt tatgtaaatt
     4021 aggaaacaaa gaggctttac aagaagttgt taatatattt gagaaaacta taatgaaaga
     4081 attatttaaa tttaaaaaag aaaatagtac tatttttatg aatgagtatg actttcaaga
     4141 taaaaagagt gaaattacat taaatgtttt aaatgcaata aaaaatatgc caattgaaag
     4201 ttttgaatat aaaactgact attctgtaaa aaaatatata aggaaaacaa ttttaaataa
     4261 attgaatgag attaaaacaa aagaatttaa taagacagaa aatgaatata agtatgagtt
     4321 cgattttagc ttttttaagt ctagtgattt taatgagcct aatacagata tatttgtaca
     4381 tgatttaata gacaagcttt ctgaaaaaga aagaaaagta attaagtata aatacatata
     4441 tggaaaaagt gatgttgaaa taggagaatt gcttaattgt tctagacaat atgtaaataa
     4501 gattaagaat agggcattaa aaaatataaa gaaattttta gatgattaat tagttagaaa
     4561 atatcaagct tgaaataaaa ttttaatagg aggtttattg tggattcaga aatgtttaag
     4621 cttatagcaa ctcaaggtgc atttgcctta ctattttcat acttattatt ttatgtacta
     4681 aaggaaaata gtaaaagaga agaaaattat cagagtatta ttaaagaact tacagagttg
     4741 ttaccaagta taaaaaatga tgtagaagat ataaaaaata aattaaatag taattagaat
     4801 aaaaaagctg ataaaaaaat cagctttttt taattttctt atttacaaaa ttaaaaaatc
     4861 tcactcttta tatagtgtaa aacaaattca agcttgattt taaaaataaa aagtgaggtt
     4921 ttaaaaatga taatgagatt tataccaagt gtaaatccag gagattcagt tggaagtaag
     4981 ccaacgtttc ctgtaaatgc acaagtaaaa ggagatttct tatatttaag agatgctaat
     5041 ggaaatcaaa tagcaggaag aagtgtaagt gatggagatg aaataactgt tttaaaagta
     5101 gatcatacta aacagttagc gttagtacaa tatcctgcag gaactattta tagacaaggc
     5161 tatgtaacta atgcaacaag tattataaaa tacaaaaacg aatataattg gttaaatggt
     5221 tctactccag aaactgtata tgatgtagat aagaaaacac aaataggtag tttagatcca
     5281 agagagaaag caacaatact ttataaagta gatggaatga ctgcacttgt atatgataca
     5341 agtaaaggta aaatgactaa atcaggttta gttcactatg ctggttcggg tggatctact
     5401 ggtggcggag atataaatgg tatagcacca ggaggggaag taccaggagg attcacatat
     5461 cctaataatg ctcaggttgt tggagatgac ttatatttaa gagatgctaa tggtaatcaa
     5521 atatctggaa gagttgtaag taatggtgat aagataacag ttttagatgt aggatatact
     5581 aagcaattag ctttagtaca atatcctgct ggtagtgttg ttaggcaagg atatgttaca
     5641 aatgcaacta acttgattcg ttactttaaa caaggagaat ggttaaacgg aagtactaca
     5701 gagcctgtat tagatgagaa tggtggttca ttaggatcat taagtccata tgaagctgca
     5761 acaccattat ataagaaaaa tggaatgaca catgtagtat atgatacttc taaaggtcca
     5821 aatacaaaat caggttatgt aaaatttgag ggattgccag agttgcctga tacaggtatt
     5881 caaattcctt caacttcaca ttcacaagca actgttgaag tatatggaac aagtggaaaa
     5941 ggaagaccgt taaaagttta taaaatagga agtggtagta aagtactatt tgcaggattc
     6001 gcgttacatg gatgggaaga taactggtca aatgatggac ttgcattagt aaatatagca
     6061 aattcattaa tagaaaagat aggagattat aaagcacaaa atggtcttca tggatggaca
     6121 gtatatatag caccttgtat gaaccctgac ggagttgtgg ttaaaggaac tcataatggg
     6181 ccaggtagat gtgcggtaac tactagagtt gatatgaata gatgtttccc atataaattt
     6241 tcaccacaat atatttcaag aaactatact ggacctaatc cattaggagc accagaagct
     6301 gtagcactta aaaatttagt tgaaagaata aatgttagtt caagtgaaat ggtagtttta
     6361 gatttccatg ggtggatgaa tttcactcaa ggtaatgcag agttaggaag ctattttgga
     6421 aatcaatttg ggtttgggca taaaaactta tatagctcag gtttcttttc aagttgggca
     6481 acaactttaa ggaatacaaa agcagtttta attgagtatc ctacaaatac ttatagctat
     6541 aatgatgtta taaataaaaa ttatatagga aaaactttca atggaataat aaatattctt
     6601 aagaataatc ctaatggtgg agatgtagat aatggtggat cagattcgag tgaaattcct
     6661 tataatgcaa atggagaagt aattaacgta gaaccaacat cagcattaaa tgtaagaagt
     6721 ggtccaggaa caacatatag agcaatagga acactaaagt taggaaatag agtaactatt
     6781 ttagctaaaa ctaaaccggc tggagaaacg aaggattggt ataaaataag ttttaattat
     6841 ggaagtggat atataagaag tgatttcgtt aagctagact catctgagat taattataat
     6901 gctgtaggtg aaataataaa tgtatcatct tttttgaatg taagaagtgg tccaggtaca
     6961 aattttgaga tgttaggtaa attatataag ggggatgtag ttttaatagt atcaaagaat
     7021 ggagactggt ataagattag atatggtact acatttggat atattcataa agattatgta
     7081 tatataaata aggaaaatga taattttgtt gaaaaaaagg ttcagattgg tgcagttgaa
     7141 attaataagg ttaaaactat agatggcata gttttcgcta atataaatca gatgttaaaa
     7201 ggattttgta ataataatgg ttataccaaa gcaccatcag gagatattat agtaacagtt
     7261 cacaattttc ataaaaagat ggatgtttct aaaacattac ctatttctaa atgtaagtta
     7321 ataaatggtg attattatta taatttaaat gaattcataa gtattttagg ctatgatgaa
     7381 tttgttcaaa atatatctga ttatagtgat gttatatata aatatgtgta tataggaatg
     7441 gatgatgaga cacagtttac aattcatgaa gctttagatg cattagggtt tataccagtt
     7501 gtaggtgatg ttattgatgg tgttaatgct attatgtatg ctttggaaaa agattatctt
     7561 aatgcagcac ttagtttagg agctataatt ccagttatag gtagtccatt ctttaaaggt
     7621 ggtaaatatg gatttaaaat aatgagtgga ttctcaaaag ttgctaataa atccaagaaa
     7681 tttgtcaaaa aacttgatat tactgaaggt aggtatgtgt atagagctat acatgatgct
     7741 gatttacaaa gaataaaaga tggcttagga ttacaggcaa agaatcctaa tggaacttgg
     7801 agtttagaag aacacatagt taggggatca aattcagaat catggaaaaa tgatagattt
     7861 atatcaacat cgcttgattt agagatttca aggatattta attcttcaaa aaatttaggt
     7921 ataataaaaa tagatttaga aaaagttcca aaggaattaa tatataaatc atataaggaa
     7981 ttccctttat atgatattaa tggacacaga tctttagctt atgaattttc agtttggcaa
     8041 caagaaataa gtattcttaa agaaattcct agggatgcat ttgaatttat agaataagta
     8101 aaaggagtaa ttatgagaaa tatacgatat gttttaactc cagaggcgta tggttccaat
     8161 ggtgaattta tagataaaat tggtacatta ggagatttag tagttgatac tggaatgcta
     8221 ttaagacctc aatttgataa aactattcct aatatcaaag tgttaaattc tttatttaga
     8281 gaaggatggt atccaagaag tgctgaatgg gagccttttg aaatagattc ggatgaatac
     8341 aatgaattag ttgaatacct tctaagttta cctttaaata aaccatataa gttagaataa
     8401 tttatagagt tttaataaat agaatatata agcaatttta gttaattaga ggacaaagtt
     8461 agtttacatt gttctctaat tttgtatata aatatttaat aagatagaat ggtggattaa
     8521 gattatgaaa tatacattag aattaatttg taatgaattc aataaaaata aaataattga
     8581 ttttttattt ttttgggggc atacagaaaa taataaaaaa gaagttacaa aagcttgttt
     8641 aagtcagtgg tattactctt attttaagat tgatggtatt gcatattgtt gtgctgagca
     8701 gtatatgatg gctgaaaagg ctagattatt taaagatttt aatgttttag ataaaatatt
     8761 agcagcctct aaacaaagtg agattaaaag attaggtaga atggttaaaa atttcaatga
     8821 aaatatttgg aatgaaagaa aaattgatat tgttgttaaa ggaaatatag aaaaattttc
     8881 tcagaatgag gaattgaaaa aatttttatt aaatacaaaa aataaaataa tagttgaagc
     8941 gagtccatat gattctattt ggggagttgg actatcagtt aataatgaaa atataactaa
     9001 tcctaacaaa tggagtggaa aaaatctact aggatttgct ttgatggagg ttagagattt
     9061 tcttaatgaa atttagaata taaaatttca atagtataat aagttatatt atttttttaa
     9121 atgtaatagt atgaacttat caatgaatta aaaatagagc gtagttttgg aaaaaatatt
     9181 atagttttaa atatttttat ataataacta aaatttatag tttacataat aagaaaaaaa
     9241 gcgtaaaatt aagacataaa atttccaatt aaaattgata attttagtaa agggtagaaa
     9301 ttttgattca aaaataaaaa aaaagcactt caaattgaag gctttatata acaacttcgg
     9361 ttcaattaat tgtttggcga caattgattg taacttaagg tattacaagt accaagaagc
     9421 taaggaataa acgaacactt caaaccagac ctaaagtgaa ggtaacccaa ccgaagatct
     9481 tatatctaat tgatatacat ttagtatatt aaaatgataa taaattttca agaggtttta
     9541 gtaattttgt ttacataatt acatgtttac aatagaaatt ctaagcttag gtattaacta
     9601 cctaagcttt ttttgttgat atatagaatt taatatagaa aaaatcctag ttataggtga
     9661 gtggttaaag gaataacact ataaaaaact ggtcggctca ccaccgatag cagctccgtt
     9721 agatggaaat agcgacttct tagacaagct atttaagata atagtttctt agtagtggag
     9781 tgcctgtcct ggtggagttt gctttagctc ctaggggtgt gtgtagagtt acgtggtagt
     9841 atgcttgata aaaccagacc taagcaagaa agatacacat agtggttgga agccacggga
     9901 ttaaatgcga cacggatacc tcaatggctc caagccatta atataaatgt ttgctgatcc
     9961 cctttgtagt atgtaatatt ttggaaatta aatctattta tgtactacaa ggggggggag
    10021 cgagccgtat tcctaattca ccaaaccatt aacagatgct tgattgaaag tcaacaaaaa
    10081 aatacaataa agttagcgag tgaaggggta aaaaaaggat atatagtatt tataattata
    10141 tttatttaag agagggttat atagttacgg ctaagaagaa tagtaagaag tattatgcaa
    10201 ttaaagttgg taagggagta aagaataaga ttgttactac ttggaaggaa tgtagtgaat
    10261 tagtattagg ttttaattca atatataaaa gttttaaaac tagagaagaa gcagaacaat
    10321 acttaaatgg aataaaggat aatagtattg atattgtatt agaaaaaaat aagaaagcaa
    10381 gagaatataa tactaagaaa aagaaatcaa ctagaagttt acaaggtata agaattgata
    10441 aagagcttta tgataggttt caagaaaagt gtaataaatt tgagtttaca gaggaaaaag
    10501 ctattactct tttaatagaa gaatggctta gttaaatatt ttgtagttaa tatattatgg
    10561 cttgaagtgg gataatatag ggattttata gggcgtgttt gtggcttaga gtgggataat
    10621 tgtaaattgt tttgatatca ttgaaatact aggctttgcc tagactagaa ccttgagtga
    10681 tagcaatttc tccttatgct ctttaataag ctaaaaaaat tattttccag cttgttttct
    10741 ttgtaaaatc tatttatcta aatagacttt atttttttat ttttaataca aaatttatat
    10801 tgaaaataaa ggtttaactt tgtagttaca gaatttaatt aagtagaagt atagataaag
    10861 tgaggatttt tttgtggcta caaaagttgt aaaggatgat attataaggg ttagagtgac
    10921 caaagagcat aaagaaaaat taaaagaaat agctaagaag aagaatatta ctataagtga
    10981 aattattagt gtggctacag aaaatgaaat aaaaaagtat gaggaaaaag aaaaaaacta
    11041 taaaaaaata tgtgaaagat ctgtagctac agaagaaaag attcaagaaa ttaaatttaa
    11101 tttagaaaaa agaaaattaa aaaataaaaa aaatatattt aaaaatattt ttaatttaag
    11161 gagataatta atatgaaaaa aatatatagt tatccaagta ttttaacaaa agaaaatgat
    11221 ggaataacag taactttccc gaattttaaa gggtgtattt cttgtggcta cacttttgaa
    11281 gaagctataa aaaatggaaa acaggcttta ggtttacata taaatggctt aatagaagat
    11341 aatgaagtgc tgtcagatcc aaaagaaata aaaaatataa aattatatga aaatcaaaag
    11401 atagagttta ttgaggttga aatagaagaa tagcaagtat agattttgtc atgacacttt
    11461 aaagttgtta tatcaaaatc atcattgtta ggaataatcc taagacctat ttaacataat
    11521 aaaattaaat ttaattgtgg ttacaaggtt taaaaatgta gctacaatgt tttttagcta
    11581 tgattttaac agtatctagg aagcttttta agttttttat gtgactacaa gaaaaatttt
    11641 tgtagctaca taaagtttta tataaatttg ataaaacttt gaaaatatta taaaattaat
    11701 gtattagatt attacaatat aagttaaaaa agttttttac ttatattcaa cttttttaaa
    11761 ctataggttt aagattactt caattttttt aagctaaagc ttaggattac ttaaatttta
    11821 aaatagcctt ttaaaggcta aggataacat aaaaaaataa atattagctt ataaaagttt
    11881 ataagcaaga ttaataacaa atagataaat ctaaaaattt taaaaagaaa ataaatatta
    11941 gtatttacca gtaaacctgg tgtttaatat gtcttttata gtggtgtagc cacttactaa
    12001 ttatttagtt ttaaatttta aaatttggta gatttttttt atttgttttt ttatataaat
    12061 ttagtttttt aaaaatttta ttttaaaaat ttttaaaaaa caggatacca aattaatttt
    12121 ttgcatttgt aaaatgcaaa aaataatatt gctgcggagc tgcaatatta ttttagtgtt
    12181 tattttttaa tagacatttt gtaggtttct atttatttag aaatttgaag aatcgacggt
    12241 tattgcttaa aagctcaata acggatttta tttagttctc ctagtgttgg agaattgtga
    12301 ttgaaaggaa aaagctttta ttattttttt atttttagta tataccatgt cggcattaac
    12361 aggcggacat agggagcctg ttaatgccga acataag
//
