---------------------------------------------------------------------- Changes included in 2024-05-02.2 ---------------------------------------------------------------------- In addition to the usual addition of new alleles and genes there were several major changes in this release. - Many updates to HMMs and hierarchy structure based on a review of HMMs and new QC checks. - Extensive Shiga toxin gene (Stx) curation and changes in how Stx proteins are reported. Some reference accessions were removed and others added to harmonize our references with other databases. These changes are part of a collaboration to better characterize and standardize Stx subtype nomenclature, and are in preparation for a manuscript and tool to correctly assign known Stx subtypes. We are no longer including a subtype for each of the Stx proteins since it can be misleading because many of the subunit proteins can be part of multiple Stx subtypes. That information can still be found in the Subclass and Protein name fields. - Collaboration with Gen-FS Salmonella Virulence Factor Working group members resulted in curator review and addition of 8 virulence genes for Salmonella based on Harhay et al., 2024 (protocols.io; https://dx.doi.org/10.17504/protocols.io.6qpvr3on3vmk/v1). - The blaOXA-18 reference was replaced to correct an early start. The new reference is 6-amino acids shorter. - For this release, we removed the HMM NF000355. That HMM is useful because it finds most or all known examples of ABC-F family ribosomal protection proteins. However, the family is sufficiently broad now that the family includes some number of ABC-F family proteins with roles other than antibiotic resistance through the ribosomal protection mechanism. Sensitivity for members of the known individual families of ribosomal protection proteins should be unaffected. Identification of candidate new ribosomal protection proteins, based on hits to the HMM NF000355, is still possible by examination of RefSeq annotation, but not directly by use of the new version of AMRFinderPlus. In upcoming releases, we plan to build new HMMs for non-overlapping subfamilies of members of family NF000355, so identification of potential novel families of ribosomal protection proteins can be performed with less risk of false-positive identifications. - Some product name cleanup for point mutation reference genes. - For consistency, we have changed the gene symbol for point mutations from 50S_L22 to rplV. In Pathogen Detection data, isolates that have not been processed recently could be referred to as "50S_L22" and should be viewed as equivalent. - New Escherichia, Salmonella, Streptococcus pneumonieae, and Enterococcus faecium point mutations. - Updated Protein name and subclass for several genes due to new information on phenotypes found in the literature. - Sequences for aalE and cstB were found to be incorrect and were replaced. Summary: Total proteins: 8180 Core proteins: 6941 Plus proteins: 1236 AMR proteins: 6990 STRESS proteins: 257 VIRULENCE proteins: 933 PubMed references: 4456 Point mutations: 1309 Point mutation reference sequences: 234 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae, Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes, Vibrio_cholerae, Vibrio_parahaemolyticus, Vibrio_vulnificus HMMs: 743 Updates since release 2024-01-31.1: Proteins added: 145 Core proteins added: 76 Plus proteins added: 69 AMR proteins added: 79 STRESS proteins added: 4 VIRULENCE proteins added: 62 Alleles added: 73 PubMed references added: 78 PubMed references removed: 4 Point mutations added: 30 Proteins removed: 16 Core proteins removed: 1 Plus proteins removed: 15 Point mutations removed 11 Reference Gene Catalog entries changed: 270 Hierarchy nodes added: 51 Hierarchy nodes removed: 3 Hierarchy nodes changed: 62 Added proteins core AMR AMR lnu(I) NG_242532.1 WP_008992950.1 lincosamide nucleotidyltransferase Lnu(I) tet(65) NG_242533.1 WP_152609570.1 tetracycline efflux MFS transporter Tet(65) vga(F) NG_242534.1 WP_172065992.1 ABC-F type ribosomal protection protein Vga(F) cmeB NG_242531.1 WP_254563251.1 multidrug efflux RND transporter permease subunit CmeB, ciprofloxacin and florfenicol resistance type blaADC-347 NG_242535.1 WP_138149148.1 extended-spectrum class C beta-lactamase ADC-347 blaADC-348 NG_242536.1 WP_096877503.1 extended-spectrum class C beta-lactamase ADC-348 blaADC-349 NG_242537.1 WP_334264835.1 extended-spectrum class C beta-lactamase ADC-349 blaADC-350 NG_242538.1 WP_016804156.1 extended-spectrum class C beta-lactamase ADC-350 blaADC-351 NG_242539.1 WP_338424097.1 extended-spectrum class C beta-lactamase ADC-351 blaADC-352 NG_242540.1 WP_338424098.1 extended-spectrum class C beta-lactamase ADC-352 blaADC-353 NG_242541.1 WP_338424099.1 extended-spectrum class C beta-lactamase ADC-353 blaCMY-188 NG_242543.1 WP_338424100.1 class C beta-lactamase CMY-188 blaCMY-189 NG_242544.1 WP_046670810.1 class C beta-lactamase CMY-189 blaDYB-1 NG_242545.1 WP_338373280.1 subclass B1 metallo-beta-lactamase DYB-1 blaIMI-25 NG_242546.1 WP_320734326.1 carbapenem-hydrolyzing class A beta-lactamase IMI-25 blaIMI-26 NG_242547.1 WP_320735136.1 carbapenem-hydrolyzing class A beta-lactamase IMI-26 blaIMI-27 NG_242548.1 WP_111966200.1 carbapenem-hydrolyzing class A beta-lactamase IMI-27 blaKHM-2 NG_242549.1 WP_338424101.1 subclass B1 metallo-beta-lactamase KHM-2 blaKPC-169 NG_242550.1 WP_338424102.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-169 blaKPC-171 NG_242551.1 WP_338424103.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-171 blaKPC-172 NG_242552.1 WP_338424104.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-172 blaKPC-173 NG_242553.1 WP_338424105.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-173 blaKPC-174 NG_242554.1 WP_338424106.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-174 blaKPC-175 NG_242555.1 WP_338424107.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-175 blaKPC-177 NG_242556.1 WP_338424108.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-177 blaKPC-209 NG_242557.1 WP_338424109.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-209 blaKPC-211 NG_242558.1 WP_336433394.1 carbapenem-hydrolyzing class A beta-lactamase KPC-211 blaKPC-212 NG_242559.1 WP_336434105.1 carbapenem-hydrolyzing class A beta-lactamase KPC-212 blaKPC-213 NG_242560.1 WP_336464807.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-213 blaKPC-214 NG_242561.1 WP_336433450.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-214 blaKPC-215 NG_242562.1 WP_336433517.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-215 blaKPC-216 NG_242563.1 WP_338424110.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-216 blaMUN-1 NG_242564.1 WP_206340447.1 MUN family extended-spectrum class A beta-lactamase MUN-1 blaMUN-2 NG_242565.1 WP_254887308.1 MUN family extended-spectrum class A beta-lactamase MUN-2 blaMUN-3 NG_242566.1 WP_234225171.1 MUN family extended-spectrum class A beta-lactamase MUN-3 blaMUN-4 NG_242567.1 WP_224206459.1 MUN family extended-spectrum class A beta-lactamase MUN-4 blaMUN-5 NG_242568.1 WP_254888401.1 MUN family extended-spectrum class A beta-lactamase MUN-5 blaMUN-6 NG_242569.1 WP_258885795.1 MUN family extended-spectrum class A beta-lactamase MUN-6 blaNDM-64 NG_242571.1 WP_338424111.1 subclass B1 metallo-beta-lactamase NDM-64 blaNDM-65 NG_242572.1 WP_338424112.1 subclass B1 metallo-beta-lactamase NDM-65 blaNDM-66 NG_242573.1 WP_336187019.1 subclass B1 metallo-beta-lactamase NDM-66 blaNDM-67 NG_242574.1 WP_338424113.1 subclass B1 metallo-beta-lactamase NDM-67 blaNDM-68 NG_242575.1 WP_338424114.1 subclass B1 metallo-beta-lactamase NDM-68 blaOXA-1226 NG_242576.1 WP_338424115.1 OXA-48 family class D beta-lactamase OXA-1226 blaOXA-1227 NG_242577.1 WP_338424116.1 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1227 blaOXA-1228 NG_242578.1 WP_338424117.1 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1228 blaOXA-1229 NG_242579.1 WP_338424118.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1229 blaOXA-1230 NG_242580.1 WP_338424119.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1230 blaOXA-1231 NG_242581.1 WP_338424120.1 OXA-10 family class D beta-lactamase OXA-1231 blaOXA-1232 NG_242582.1 WP_338424121.1 OXA-10 family class D beta-lactamase OXA-1232 blaOXA-1233 NG_242583.1 WP_338424122.1 OXA-10 family class D beta-lactamase OXA-1233 blaOXA-1234 NG_242584.1 WP_338424123.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1234 blaOXA-1235 NG_242585.1 WP_338424124.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1235 blaOXA-1236 NG_242586.1 WP_338424125.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1236 blaOXA-1237 NG_242587.1 WP_334377767.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1237 blaOXA-1238 NG_242588.1 WP_338424126.1 class D beta-lactamase OXA-1238 blaOXA-1239 NG_242589.1 WP_338424127.1 carbapenem-hydrolyzing class D beta-lactamase OXA-1239 blaOXA-1240 NG_242590.1 WP_338424128.1 OXA-48 family class D beta-lactamase OXA-1240 blaOXA-18 NG_049480.2 WP_277915723.1 extended-spectrum class D beta-lactamase OXA-18 blaPAM-5 NG_242592.1 WP_184489348.1 subclass B3 metallo-beta-lactamase PAM-5 blaPDC-582 NG_242593.1 WP_338424129.1 class C beta-lactamase PDC-582 blaPDC-583 NG_242594.1 WP_338424130.1 class C beta-lactamase PDC-583 blaPDC-584 NG_242595.1 WP_338424131.1 class C beta-lactamase PDC-584 blaPDC-585 NG_242596.1 WP_338424132.1 class C beta-lactamase PDC-585 blaPDC-586 NG_242597.1 WP_338424133.1 class C beta-lactamase PDC-586 blaPDC-587 NG_242598.1 WP_338424134.1 class C beta-lactamase PDC-587 blaPDC-588 NG_242599.1 WP_338424135.1 class C beta-lactamase PDC-588 blaPDC-589 NG_242600.1 WP_338424136.1 class C beta-lactamase PDC-589 blaPDC-590 NG_242601.1 WP_338424137.1 class C beta-lactamase PDC-590 blaPDC-591 NG_242602.1 WP_338424138.1 class C beta-lactamase PDC-591 blaPDC-592 NG_242603.1 WP_338424139.1 class C beta-lactamase PDC-592 blaPNC-1 NG_242604.1 WP_322881141.1 class C beta-lactamase PNC-1 blaSED-2 NG_242605.1 WP_338424140.1 class A beta-lactamase SED-2 blaSHV-244 NG_242606.1 WP_064738859.1 class A beta-lactamase SHV-244 blaVEB-34 NG_242607.1 WP_338424141.1 extended-spectrum class A beta-lactamase VEB-34 blaVIM-87 NG_242608.1 WP_338424142.1 subclass B1 metallo-beta-lactamase VIM-87 plus AMR AMR cxpE CP008706.1 AKA30736.1 chloramphenicol efflux transporter CxpE norM AB010463.1 BAA31456.1 multidrug efflux MATE transporter NorM mcr-11.1 CP042930.1 QEY54480.1 phosphoethanolamine--lipid A transferase MCR-11.1 plus STRESS ACID gadD1 AL591975.1 CAC98526.1 glutamate decarboxylase GadD1 plus STRESS METAL merB3 LC152290.1 BAA89005.2 organomercurial lyase MerB3 merB2 LC152290.1 BAA89007.1 organomercurial lyase MerB2 merB3 AB066362.1 BAB62428.1 organomercurial lyase MerB3 plus VIRULENCE VIRULENCE stxA2 M59432.1 AAA19623.1 Shiga toxin Stx2 subunit A stxA1 M19473.1 AAA98151.1 Shiga toxin Stx1a subunit A stxA1 M19437.1 AAA98347.1 Shiga toxin Stx1a subunit A inlC U77368.1 AAB67969.1 class 1 internalin InlC2 inlD U77368.1 AAB67970.1 class 1 internalin InlD spvD AF329248.1 AAG59626.1 SPI-2 type III secretion system effector cysteine hydrolase SpvD sseK2 AE006468.2 AAL21040.1 type III secretion system effector arginine glycosyltransferase SseK2 avrA AE006468.2 AAL21745.1 type III secretion system YopJ family effector AvrA stxB2 AF479828.1 AAM88303.1 Shiga toxin Stx2c subunit B stxB2 AY286000.1 AAP37404.1 Shiga toxin Stx2g subunit B stxA2 AY443043.1 AAS07578.1 Shiga toxin Stx2c subunit A stxB2 EF441616.1 ABR10025.1 Shiga toxin Stx2b subunit B aut CP001602.2 ADB67911.1 peptidoglycan hydrolase Auto inlG CP002002.1 AEO05269.1 class 1 internalin InlG inlH CP002003.1 AEO24563.1 class 1 internalin InlH vip CP002003.1 AEO24620.1 cell invasion LPXTG protein Vip inlI CP002003.1 AEO24631.1 class 1 internalin InlI inlF CP002003.1 AEO24707.1 class 1 internalin InlF inlB CP002003.1 AEO24731.1 GW domain-containing class 2 internalin InlB lntA CP002003.1 AEO24735.1 nuclear targeted protein LntA inl-lmo0514 CP002003.1 AEO24812.1 lmo0514 family class 1 internalin Inl-lmo0514 inl-lmo0610 CP002003.1 AEO24908.1 lmo0610 family class 1 internalin Inl-lmo0610 inlK CP002003.1 AEO25637.1 class 1 internalin InlK inlP CP002003.1 AEO26812.1 class 3 internalin InlP inlC CP007160.1 AHJ03495.1 class 3 internalin InlC ami CP007194.1 ASH48222.1 autolysin Ami cpa KY978630.1 ASR82161.1 omptin family outer membrane protease Cpa stxA2 AB048228.1 BAB83004.1 Shiga toxin Stx2b subunit A stxB1 AB071622.1 BAC10990.1 Shiga toxin Stx1c subunit B inlE AJ007319.1 CAA07458.1 class 1 internalin InlE gtgA FQ312003.1 CBW17061.1 type III secretion system effector protease GtgA sseK3 FQ312003.1 CBW18025.1 type III secretion system effector arginine glycosyltransferase SseK3 inlL HG421741.1 CDG45949.1 class 1 internalin InlL stxA2 RUOX02000009.1 EED0303792.1 Shiga toxin Stx2j subunit A stxA2 AARDFE010000017.1 EES5259043.1 Shiga toxin Stx2j subunit A stxA2 AARGRV010000082.1 EET7735230.1 Shiga toxin Stx2m subunit A stxB2 AARGRV010000082.1 EET7735231.1 Shiga toxin Stx2m subunit B stxA2 AASBEA010000053.1 EFA5701809.1 Shiga toxin Stx2j subunit A stxA2 AASOQD010000025.1 EFE9806287.1 Shiga toxin Stx2j subunit A stxA2 AATFJO020000039.1 EMA1832120.1 Shiga toxin Stx2j subunit A aalE AQEW01000031.1 EMX33340.1 CS23 fimbrial major subunit AalE stxB2 BGDW01000072.1 GDQ67223.1 Shiga toxin Stx2c subunit B stxA2 BGDW01000072.1 GDQ67229.1 Shiga toxin Stx2c subunit A stxA2 BGEN01000020.1 GDR53740.1 Shiga toxin Stx2 subunit A stxA2 BGGH01000007.1 GDR79703.1 Shiga toxin Stx2c subunit A stxA2 WSHT01000077.1 KAE9951533.1 Shiga toxin Stx2c subunit A stxA2 LGZW01000080.1 KNG05165.1 Shiga toxin Stx2c subunit A stxA1 JACISP010000011.1 MBZ9250874.1 Shiga toxin Stx1a subunit A stxA1 JAOQKQ010000001.1 MCW3225953.1 Shiga toxin Stx1a subunit A stxB2 JAOQKQ010000001.1 MCW3229578.1 Shiga toxin Stx2d subunit B cstB RNIX01000076.1 MHF63232.1 CS3 fimbrial usher protein CstB stxA2 MRVY01000159.1 PAU09262.1 Shiga toxin Stx2 subunit A sspH2 CP052807.1 QJV46475.1 SPI-2 type III secretion system effector E3 ubiquitin transferase SspH2 stxA2 MZ229604.1 QZL10982.1 Shiga toxin Stx2o subunit A stxA2 MZ229605.1 QZL10984.1 Shiga toxin Stx2a subunit A stxA2 MZ229607.1 QZL10988.1 Shiga toxin Stx2b subunit A stxA2 RRSO01000070.1 TJA36680.1 Shiga toxin Stx2 subunit A stxA1 CP061239.1 UIU88878.1 Shiga toxin Stx1a subunit A stxA2 CP113091.1 WAK52085.1 Shiga toxin Stx2o subunit A stxA2 CP113092.1 WAK53220.1 Shiga toxin Stx2n subunit A lpfB CP149214.1 WXV87835.1 long polar fimbrial chaperone LpfB invA CP149285.1 WXW86397.1 type III secretion system export apparatus protein InvA Added point mutations core AMR POINT baeS_Q163E TEMOCILLIN Escherichia baeS_R153P TEMOCILLIN Escherichia baeS_T175P TEMOCILLIN Escherichia dltC_S63C DAPTOMYCIN Enterococcus_faecium folP_F28I SULFONAMIDE Salmonella folP_F28L SULFONAMIDE Salmonella folP_R171P SULFONAMIDE Salmonella ftsI_R335RVPYR CEPHALOSPORIN Escherichia liaR_S19F DAPTOMYCIN Enterococcus_faecium rplD_G74D ERYTHROMYCIN/TYLOSIN Campylobacter rplD_KG68del AZITHROMYCIN/CHLORAMPHENICOL/CLARITHROMYCIN/ERYTHROMYCIN/LINEZOLID Streptococcus_pneumoniae rplD_WR65del AZITHROMYCIN/CHLORAMPHENICOL/CLARITHROMYCIN/ERYTHROMYCIN/LINEZOLID Streptococcus_pneumoniae rplV_A103C ERYTHROMYCIN Campylobacter rplV_A103V MACROLIDE Campylobacter rplV_A103V MACROLIDE Campylobacter rplV_A84D MACROLIDE Campylobacter rplV_A84D MACROLIDE Campylobacter rplV_A88E MACROLIDE Campylobacter rplV_A88E MACROLIDE Campylobacter rplV_G86E MACROLIDE Campylobacter rplV_G86E MACROLIDE Campylobacter rplV_G86V MACROLIDE Campylobacter rplV_G86V MACROLIDE Campylobacter rplV_H97HTSH ERYTHROMYCIN/TYLOSIN Campylobacter rplV_H97HTSH ERYTHROMYCIN/TYLOSIN Campylobacter rplV_R85RARAR ERYTHROMYCIN/TYLOSIN Campylobacter rplV_R85RARAR ERYTHROMYCIN/TYLOSIN Campylobacter rpoB_G482D DAPTOMYCIN/RIFAXIMIN Enterococcus_faecium rpoB_H486Y DAPTOMYCIN/RIFAXIMIN Enterococcus_faecium rpoC_T641K DAPTOMYCIN Enterococcus_faecium Removed proteins core AMR AMR blaOXA-18 NG_049480.1 WP_063861237.1 extended-spectrum class D beta-lactamase OXA-18 plus VIRULENCE VIRULENCE stxA1a M16625.1 AAA98099.1 Shiga toxin Stx1a subunit A stxA2a AY443054.1 AAS07600.1 Shiga toxin Stx2a subunit A stxA2c EU086525.1 ABU55302.1 Shiga toxin Stx2c subunit A aalE JQ434477.1 AFD29291.1 CS23 fimbrial major subunit AalE stxB2b AB012101.1 BAA77750.1 Shiga toxin Stx2b subunit B stxB2c AB071845.1 BAB68370.1 Shiga toxin Stx2c subunit B stxA2b AB048224.1 BAB82996.1 Shiga toxin Stx2b subunit A stxB2g AB048227.1 BAB83003.1 Shiga toxin Stx2g subunit B stxA2c X07865.1 CAA30714.1 Shiga toxin Stx2c subunit A cstB X16944.1 CAA34816.1 CS3 fimbrial usher protein CstB stxA2a Z37725.1 CAA85780.1 Shiga toxin Stx2a subunit A stxA2o AARLAS010000016.1 EEV0948227.1 Shiga toxin Stx2o subunit A stxA2n CP113094.1 WAK61649.1 Shiga toxin Stx2n subunit A stxA2m OQ054797.1 WGO76391.1 Shiga toxin Stx2m subunit A stxB2m OQ054797.1 WGO76392.1 Shiga toxin Stx2m subunit B Removed point mutations core AMR POINT 50S_L22_A103C ERYTHROMYCIN Campylobacter 50S_L22_A103V MACROLIDE Campylobacter 50S_L22_A103V MACROLIDE Campylobacter 50S_L22_A84D MACROLIDE Campylobacter 50S_L22_A84D MACROLIDE Campylobacter 50S_L22_A88E MACROLIDE Campylobacter 50S_L22_A88E MACROLIDE Campylobacter 50S_L22_G86E MACROLIDE Campylobacter 50S_L22_G86E MACROLIDE Campylobacter 50S_L22_G86V MACROLIDE Campylobacter 50S_L22_G86V MACROLIDE Campylobacter Changed reference gene catalog records stxA2 AAA16360.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxB2 AAA16361.1 gene_family: stxB2b -> stxB2 subclass: STX2B -> stxB2b stxA2 AAA16362.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxA2 AAA19189.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxB2 AAA19190.1 gene_family: stxB2e -> stxB2 subclass: STX2E -> stxB2e stxA2 AAA24632.1 gene_family: stxA2f -> stxA2 subclass: STX2F -> stxA2f stxB2 AAA24633.1 gene_family: stxB2f -> stxB2 subclass: STX2F -> stxB2f stxA1 AAA71893.1 gene_family: stxA1a -> stxA1 subclass: STX1A -> stxA1a stxB1 AAA71894.1 gene_family: stxB1a -> stxB1 subclass: STX1A -> stxB1a merB AAC38230.1 class: MERCURY -> hierarchy_node: merB -> merB_gen subclass: ORGANOMERCURY -> stxA2 AAC45964.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxB2 AAC45965.1 gene_family: stxB2e -> stxB2 subclass: STX2E -> stxB2e stxA2 AAD12174.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxA2 AAG01033.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c mexE AAG05881.1 product_name: MexE family multidrug efflux RND transporter periplasmic adaptor subunit -> multidrug efflux RND transporter periplasmic adaptor subunit MexE norM AAG27731.1 hierarchy_node: norM -> norM-Burk product_name: sodium-coupled multidrug efflux MATE transporter NorM -> multidrug efflux MATE transporter NorM stxA2 AAK66972.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxA2 AAM22256.1 gene_family: stxA2d -> stxA2 hierarchy_node: stxA2d -> stxA2_acd product_name: Shiga toxin Stx2d subunit A -> Shiga toxin Stx2 subunit A subclass: STX2D -> stxA2 stxB2 AAM22257.1 gene_family: stxB2d -> stxB2 subclass: STX2D -> stxB2d stxA2 AAM70045.1 gene_family: stxA2a -> stxA2 subclass: STX2A -> stxA2a stxA2 AAM88302.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxB2 AAM90978.1 gene_family: stxB2a -> stxB2 subclass: STX2A -> stxB2a stxA2 AAN77057.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxA2 AAN77061.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxA2 AAN77063.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxA1 AAO19475.1 gene_family: stxA1d -> stxA1 subclass: STX1D -> stxA1d stxB1 AAO19476.1 gene_family: stxB1d -> stxB1 subclass: STX1D -> stxB1d stxA2 AAP37403.1 gene_family: stxA2g -> stxA2 subclass: STX2G -> stxA2g stxA2 AAQ17546.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxA2 AAS07580.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxB2 AAS07581.1 gene_family: stxB2c -> stxB2 subclass: STX2C -> stxB2c stxA2 AAS07582.1 gene_family: stxA2c -> stxA2 hierarchy_node: stxA2c -> stxA2_acd product_name: Shiga toxin Stx2c subunit A -> Shiga toxin Stx2 subunit A subclass: STX2C -> stxA2 stxA2 AAS07586.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxA2 AAS07588.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxB2 AAS07589.1 gene_family: stxB2d -> stxB2 subclass: STX2D -> stxB2d stxA2 AAS07590.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxA2 AAS07596.1 gene_family: stxA2c -> stxA2 hierarchy_node: stxA2c -> stxA2_acd product_name: Shiga toxin Stx2c subunit A -> Shiga toxin Stx2 subunit A subclass: STX2C -> stxA2 stxA2 AAS07606.1 gene_family: stxA2a -> stxA2 subclass: STX2A -> stxA2a cvaB AAS50165.1 gene_family: mchF -> cvaB hierarchy_node: mchF -> cvaB product_name: microcin H47 export transporter peptidase/ATP-binding subunit MchF -> colicin V export peptidase/ABC transporter CvaB stxA2 AAT65972.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxA2 AAT66000.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxA2 AAT66010.1 gene_family: stxA2a -> stxA2 subclass: STX2A -> stxA2a stxB2 AAT66011.1 gene_family: stxB2a -> stxB2 hierarchy_node: stxB2a -> stxB2 product_name: Shiga toxin Stx2a subunit B -> Shiga toxin Stx2 subunit B subclass: STX2A -> stxB2 stxA2 AAT66012.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxA2 AAU88208.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxA2 AAY63864.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxA2 ABB36584.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxA2 ABB36586.1 gene_family: stxA2d -> stxA2 hierarchy_node: stxA2d -> stxA2_acd product_name: Shiga toxin Stx2d subunit A -> Shiga toxin Stx2 subunit A subclass: STX2D -> stxA2 stxA2 ABC67318.2 gene_family: stxA2a -> stxA2 subclass: STX2A -> stxA2a stxB2 ABR09925.1 gene_family: stxB2a -> stxB2 subclass: STX2A -> stxB2a stxA2 ABR09934.1 gene_family: stxA2c -> stxA2 hierarchy_node: stxA2c -> stxA2_acd product_name: Shiga toxin Stx2c subunit A -> Shiga toxin Stx2 subunit A subclass: STX2C -> stxA2 stxB2 ABR09935.1 gene_family: stxB2c -> stxB2 hierarchy_node: stxB2c -> stxB2 product_name: Shiga toxin Stx2c subunit B -> Shiga toxin Stx2 subunit B subclass: STX2C -> stxB2 stxA2 ABR09936.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxB2 ABR09937.1 gene_family: stxB2d -> stxB2 hierarchy_node: stxB2d -> stxB2 product_name: Shiga toxin Stx2d subunit B -> Shiga toxin Stx2 subunit B subclass: STX2D -> stxB2 stxB2 ABR09945.1 gene_family: stxB2a -> stxB2 subclass: STX2A -> stxB2a stxB2 ABR09961.1 gene_family: stxB2a -> stxB2 subclass: STX2A -> stxB2a stxB2 ABR09963.1 gene_family: stxB2a -> stxB2 subclass: STX2A -> stxB2a stxA2 ABR10024.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxA2 ACU32684.1 gene_family: stxA2a -> stxA2 subclass: STX2A -> stxA2a stxA2 AGB13719.2 gene_family: stxA2k -> stxA2 subclass: STX2K -> stxA2k cvaB AGC14252.1 gene_family: mchF -> cvaB hierarchy_node: mchF -> cvaB product_name: microcin H47 export transporter peptidase/ATP-binding subunit MchF -> colicin V export peptidase/ABC transporter CvaB stxB1 AHJ80154.1 gene_family: stxB1e -> stxB1 subclass: STX1E -> stxB1e stxA1 AHJ80155.1 gene_family: stxA1e -> stxA1 subclass: STX1E -> stxA1e stxB2 AUM09787.1 gene_family: stxB2h -> stxB2 subclass: STX2H -> stxB2h stxA2 AUM09788.1 gene_family: stxA2h -> stxA2 subclass: STX2H -> stxA2h stxA2 BAA77749.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxA2 BAA77751.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxA2 BAB68369.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxA2 BAB82994.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxA2 BAB82998.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxA2 BAB83000.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxA2 BAB83002.1 gene_family: stxA2g -> stxA2 subclass: STX2G -> stxA2g stxB2 BAB83005.1 gene_family: stxB2b -> stxB2 subclass: STX2B -> stxB2b stxB2 BAB83007.1 gene_family: stxB2b -> stxB2 subclass: STX2B -> stxB2b stxA2 BAB83020.1 gene_family: stxA2g -> stxA2 subclass: STX2G -> stxA2g stxA1 BAB83022.1 gene_family: stxA1c -> stxA1 subclass: STX1C -> stxA1c stxB1 BAB83023.1 gene_family: stxB1c -> stxB1 subclass: STX1C -> stxB1c stxA2 BAB83024.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxA1 BAC10987.1 gene_family: stxA1a -> stxA1 subclass: STX1A -> stxA1a stxB1 BAC10988.1 gene_family: stxB1a -> stxB1 subclass: STX1A -> stxB1a stxB1 BAC10992.1 gene_family: stxB1c -> stxB1 subclass: STX1C -> stxB1c stxA1 BAC78639.1 gene_family: stxA1a -> stxA1 subclass: STX1A -> stxA1a stxB1 BAC78640.1 gene_family: stxB1a -> stxB1 subclass: STX1A -> stxB1a stxA2 BAH86759.1 gene_family: stxA2f -> stxA2 subclass: STX2F -> stxA2f stxB2 BAH86760.1 gene_family: stxB2f -> stxB2 subclass: STX2F -> stxB2f stxB2 CAA30715.1 gene_family: stxB2a -> stxB2 subclass: STX2A -> stxB2a cvaB CAA40744.1 gene_family: mchF -> cvaB hierarchy_node: mchF -> cvaB product_name: microcin H47 export transporter peptidase/ATP-binding subunit MchF -> colicin V export peptidase/ABC transporter CvaB stxA2 CAA43585.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxA2 CAA46767.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxB2 CAA46768.1 gene_family: stxB2b -> stxB2 subclass: STX2B -> stxB2b stxA2 CAA57171.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxA2 CAA57173.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxA2 CAA57175.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxA2 CAA57177.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxA1 CAA85366.1 gene_family: stxA1a -> stxA1 subclass: STX1A -> stxA1a stxA1 CAA85368.1 gene_family: stxA1a -> stxA1 subclass: STX1A -> stxA1a stxA1 CAA85370.1 gene_family: stxA1c -> stxA1 subclass: STX1C -> stxA1c stxB1 CAA85371.1 gene_family: stxB1c -> stxB1 subclass: STX1C -> stxB1c stxA2 CAA90630.1 gene_family: stxA2a -> stxA2 subclass: STX2A -> stxA2a stxA2 CAB64953.1 gene_family: stxA2f -> stxA2 subclass: STX2F -> stxA2f stxA2 CAB77169.2 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxB2 CAB94149.1 gene_family: stxB2a -> stxB2 subclass: STX2A -> stxB2a stxA2 CAC48396.1 gene_family: stxA2b -> stxA2 subclass: STX2B -> stxA2b stxA2 CAC48398.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxA2 CAI91198.1 gene_family: stxA2g -> stxA2 subclass: STX2G -> stxA2g stxA1 CAJ76690.1 gene_family: stxA1a -> stxA1 subclass: STX1A -> stxA1a stxA1 CAJ76692.1 gene_family: stxA1a -> stxA1 subclass: STX1A -> stxA1a mexE CAK15125.1 product_name: MexE family multidrug efflux RND transporter periplasmic adaptor subunit -> multidrug efflux RND transporter periplasmic adaptor subunit MexE stxA2 CAP17609.1 gene_family: stxA2l -> stxA2 subclass: STX2L -> stxA2l stxB2 CAP17610.1 gene_family: stxB2l -> stxB2 hierarchy_node: stxB2l -> stxB2 product_name: Shiga toxin Stx2l subunit B -> Shiga toxin Stx2 subunit B subclass: STX2L -> stxB2 stxA2 CAQ68302.1 gene_family: stxA2c -> stxA2 hierarchy_node: stxA2c -> stxA2_acd product_name: Shiga toxin Stx2c subunit A -> Shiga toxin Stx2 subunit A subclass: STX2C -> stxA2 stxA2 CAX45702.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxA2 CAX45706.1 gene_family: stxA2d -> stxA2 subclass: STX2D -> stxA2d stxA2 CAX45714.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxA2 CAX45718.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxB2 CAX45737.1 gene_family: stxB2d -> stxB2 subclass: STX2D -> stxB2d stxB2 CAX45739.1 gene_family: stxB2a -> stxB2 subclass: STX2A -> stxB2a stxA2 CAX45746.1 gene_family: stxA2c -> stxA2 subclass: STX2C -> stxA2c stxA2 CAX51714.1 gene_family: stxA2e -> stxA2 subclass: STX2E -> stxA2e stxA2 CAX53241.1 gene_family: stxA2i -> stxA2 subclass: STX2I -> stxA2i stxB2 CAX53242.1 gene_family: stxB2i -> stxB2 subclass: STX2I -> stxB2i stxB2 EED0303793.1 gene_family: stxB2j -> stxB2 subclass: STX2J -> stxB2j stxB2 EEV0948228.1 gene_family: stxB2o -> stxB2 subclass: STX2O -> stxB2o norM EFF39147.1 hierarchy_node: norM -> norM-NG stxB2 QHR28666.1 gene_family: stxB2k -> stxB2 hierarchy_node: stxB2k -> stxB2 product_name: Shiga toxin Stx2k subunit B -> Shiga toxin Stx2 subunit B subclass: STX2K -> stxB2 stxA2 QHR28667.1 gene_family: stxA2k -> stxA2 subclass: STX2K -> stxA2k stxA2 QZN05543.1 gene_family: stxA2j -> stxA2 subclass: STX2J -> stxA2j stxB2 WAK53219.1 gene_family: stxB2n -> stxB2 subclass: STX2N -> stxB2n fosB WP_000920239.1 hierarchy_node: fosB-Saur -> fosB_gen aac(3)-C1264 WP_034000523.1 genbank_nucleotide_accession: ABKGBU020000026.1 -> ABKGBU030000026.1 genbank_protein_accession: EKW6221576.1 -> EML4797591.1 blaCMH-9 WP_058650678.1 genbank_nucleotide_accession: ABFHGH020000056.1 -> ABFHGH030000056.1 genbank_protein_accession: EKU2771784.1 -> EMN0879540.1 blaCTX-M-178 WP_104009847.1 product_name: extended-spectrum class A beta-lactamase CTX-M-178 -> inhibitor-resistant class A beta-lactamase CTX-M-178 pubmed_reference: -> 38366372 subclass: CEPHALOSPORIN -> BETA-LACTAM blaCTX-M-255 WP_254205601.1 product_name: extended-spectrum class A beta-lactamase CTX-M-255 -> inhibitor-resistant class A beta-lactamase CTX-M-255 pubmed_reference: -> 38366372 subclass: CEPHALOSPORIN -> BETA-LACTAM blaNDM-30 WP_197749405.1 product_name: subclass B1 metallo-beta-lactamase NDM-30 -> taniborbactam-resistant subclass B1 metallo-beta-lactamase NDM-30 pubmed_reference: -> 38047644 subclass: CARBAPENEM -> CARBAPENEM/TANIBORBACTAM blaNDM-50 WP_274293087.1 genbank_nucleotide_accession: ABJWWM020000052.1 -> ABJWWM030000052.1 genbank_protein_accession: EKV8557274.1 -> EMM3083081.1 blaOXA-1149 WP_150664304.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1152 WP_150662373.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-258 WP_063569909.1 product_name: class D beta-lactamase OXA-258 -> carbapenem-hydrolyzing class D beta-lactamase OXA-258 blaOXA-925 WP_100507493.1 product_name: class D beta-lactamase OXA-925 -> carbapenem-hydrolyzing class D beta-lactamase OXA-925 blaOXA-955 WP_213994600.1 genbank_nucleotide_accession: AAYMEH020000029.1 -> AAYMEH030000029.1 genbank_protein_accession: EKY1045811.1 -> EMM9379972.1 cls_H215R WP_002289473.1 pubmed_reference: -> 26200029 cls_R218Q WP_002289473.1 pubmed_reference: -> 26200029 colS_A106V WP_003094037.1 product_name: HAMP domain-containing sensor histidine kinase colS -> HAMP domain-containing sensor histidine kinase ColS czcS_V194L WP_003113318.1 product_name: sensor histidine kinase czcS -> sensor histidine kinase CzcS dfrB_A135T WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB dfrB_F99I WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB dfrB_F99S WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB dfrB_F99Y WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB dfrB_H150R WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB dfrB_H31N WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB dfrB_L21V WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB dfrB_L25I WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB dfrB_L41F WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB dfrB_N60I WP_000175752.1 product_name: dihydrofolate reductase -> dihydrofolate reductase DfrB folP_A184V WP_000167936.1 product_name: dihydropteroate synthase -> dihydropteroate synthase FolP folP_E208K WP_000167936.1 product_name: dihydropteroate synthase -> dihydropteroate synthase FolP folP_E258EKE WP_000167936.1 product_name: dihydropteroate synthase -> dihydropteroate synthase FolP folP_F17L WP_000167936.1 product_name: dihydropteroate synthase -> dihydropteroate synthase FolP folP_S18L WP_000167936.1 product_name: dihydropteroate synthase -> dihydropteroate synthase FolP folP_T51M WP_000167936.1 product_name: dihydropteroate synthase -> dihydropteroate synthase FolP fusA1_A555E WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_A595P WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_E100G WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_G545D WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_I61M WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_K504Q WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_L438Q WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_L464V WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_N592I WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_P554L WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_P618L WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_Q455R WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_Q678L WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_R371C WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_R680C WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_T456A WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_T671A WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_T671I WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA1_Y552C WP_003093741.1 product_name: elongation factor G -> elongation factor G FusA1 fusA_A160V WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_A376V WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_A655E WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_A655P WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_A655V WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_C473S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_D189G WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_D189V WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_D373N WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_D387I WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_D434N WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_D463G WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_E233Q WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_E444K WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_E444V WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_F652S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_F88L WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_G451V WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_G452C WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_G452S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_G452V WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_G556S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_G617D WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_G664S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_H438N WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_H457L WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_H457N WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_H457Q WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_H457Y WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_I449K WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_L430S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_L456F WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_L456K WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_L461F WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_L461K WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_L461S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_M453I WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_M651I WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_P114H WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_P404L WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_P404Q WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_P406L WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_P478S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_Q115L WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_R464C WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_R464H WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_R464L WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_R464S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_R659C WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_R659H WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_R659L WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_R659S WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_S416F WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_T385N WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_T436I WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_T656K WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_V407F WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_V607I WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_V90A WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_V90I WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA fusA_Y654N WP_000090315.1 product_name: elongation factor G -> elongation factor G FusA ileS_F563L WP_000384706.1 product_name: isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS ileS_G593V WP_000384706.1 product_name: isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS ileS_H67Q WP_000384706.1 product_name: isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS ileS_R816C WP_000384706.1 product_name: isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS ileS_V588F WP_000384706.1 product_name: isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS ileS_V631F WP_000384706.1 product_name: isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS mprF_G61V WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF mprF_I420N WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF pubmed_reference: -> 33796088 mprF_L341S WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF mprF_L826F WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF pubmed_reference: -> 33796088 mprF_M347R WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF mprF_P314L WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF mprF_S295L WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF pubmed_reference: -> 33796088 mprF_S337L WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF pubmed_reference: -> 33796088 mprF_T345A WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF mprF_T345I WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF pubmed_reference: -> 33796088 mprF_T345K WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF mprF_T472K WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF mprF_V351E WP_111724484.1 product_name: bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF pbp2_S569A WP_000138348.1 product_name: penicillin-binding protein -> penicillin-binding protein PBP2 pbp4_E183A WP_123090655.1 product_name: D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4 pbp4_E218K WP_123090655.1 product_name: D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4 pbp4_F241R WP_123090655.1 product_name: D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4 pbp4_R200L WP_123090655.1 product_name: D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4 pbp4_T-266A NZ_RIXR01000001.1 product_name: D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4 pgsA_A64V WP_001025093.1 product_name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -> CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA pgsA_K66R WP_001025093.1 product_name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -> CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA pgsA_S177F WP_001025093.1 product_name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -> CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA pgsA_V59N WP_001025093.1 product_name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -> CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA vanR-Cd_T115A WP_003436401.1 product_name: vancomycin resistance response regulator transcription factor VanR-G-Cd -> vancomycin resistance response regulator transcription factor VanR-Cd Hierarchy nodes added core AMR AMR ant(9)-Ic ant(9)-Ic NF045909.1 aminoglycoside nucleotidyltransferase ANT(9)-Ic blaDYB blaDYB NF045731.1 DYB family subclass B1 metallo-beta-lactamase blaMUN blaMUN NF045651.1 MUN family extended-spectrum class A beta-lactamase blaOXA-1238_fam blaOXA NF045807.1 OXA-1238 family class D beta-lactamase blaOXA-18_fam blaOXA NF045839.1 OXA-18 family class D beta-lactamase blaOXA-258_fam blaOXA NF045795.1 OXA-258 family carbapenem-hydrolyzing class D beta-lactamase blaPNC blaPNC NF045671.1 PNC family class C beta-lactamase cmeB_RE cmeB multidrug efflux RND transporter permease subunit CmeB, ciprofloxacin and florfenicol resistance type lnu(I) lnu(I) lincosamide nucleotidyltransferase Lnu(I) tet(65) tet(65) NF045684.1 tetracycline efflux MFS transporter Tet(65) non-reported STRESS ACID gad gad glutamate-dependent acid resistance gadAB gad glutamate decarboxylase non-reported VIRULENCE VIRULENCE VIRULENCE_Lmon VIRULENCE_Salmo plus AMR AMR cxpE cxpE NF045801.1 chloramphenicol efflux transporter CxpE mcr-11 mcr-11 MCR-11 family phosphoethanolamine--lipid A transferase norM-Burk norM multidrug efflux MATE transporter NorM norM-NG norM NF000263.1 sodium-coupled multidrug efflux MATE transporter NorM norM-Vib norM multidrug efflux MATE transporter NorM plus STRESS ACID gadD1 gadD1 glutamate decarboxylase GadD1 plus STRESS METAL merB2 merB2 organomercurial lyase MerB2 merB3 merB3 organomercurial lyase MerB3 plus VIRULENCE VIRULENCE ami ami autolysin Ami aut aut peptidoglycan hydrolase Auto avrA avrA type III secretion system YopJ family effector AvrA cpa_Csak cpa omptin family outer membrane protease Cpa cvaB cvaB colicin V export peptidase/ABC transporter CvaB gtgA gtgA type III secretion system effector protease GtgA inlA inlA NF033189.1 class 1 internalin InlA inlB inlB GW domain-containing class 2 internalin InlB inlC inlC class 3 internalin InlC inlC2 inlC class 1 internalin InlC2 inlD inlD class 1 internalin InlD inlE inlE class 1 internalin InlE inlF inlF class 1 internalin InlF inlG inlG class 1 internalin InlG inlH inlH class 1 internalin InlH inlI inlI class 1 internalin InlI inlK inlK NF033186.1 class 1 internalin InlK inlL inlL class 1 internalin InlL inlP inlP class 3 internalin InlP inl_lmo0514 inl-lmo0514 lmo0514 family class 1 internalin Inl-lmo0514 inl_lmo0610 inl-lmo0610 lmo0610 family class 1 internalin Inl-lmo0610 invA invA type III secretion system export apparatus protein InvA lntA lntA nuclear targeted protein LntA lpfB lpfB long polar fimbrial chaperone LpfB spvD spvD SPI-2 type III secretion system effector cysteine hydrolase SpvD sseK2 sseK2 type III secretion system effector arginine glycosyltransferase SseK2 sseK3 sseK3 type III secretion system effector arginine glycosyltransferase SseK3 sspH2 sspH2 SPI-2 type III secretion system effector E3 ubiquitin transferase SspH2 vip vip NF033201.1 cell invasion LPXTG protein Vip Hierarchy nodes removed plus AMR AMR norM norM NF000263.1 sodium-coupled multidrug efflux MATE transporter NorM plus VIRULENCE VIRULENCE stxB2k stxB2k Shiga toxin Stx2k subunit B stxB2l stxB2l Shiga toxin Stx2l subunit B Changed Hierarchy Nodes abc-f ABC-F type ribosomal protection protein class: MACROLIDE -> RIBOSOMAL PROTECTION hmm_acc: NF000355.3 -> scope: core -> non-reported subclass: MACROLIDE -> RIBOSOMAL PROTECTION ant(6)-Ig aminoglycoside nucleotidyltransferase ANT(6)-Ig hmm_acc: -> NF033221.1 ant(9) ANT(9) family aminoglycoside nucleotidyltransferase hmm_acc: NF012212.0 -> NF012212.1 aph(3')-H48 aminoglycoside O-phosphotransferase APH(3')-H48 parent_node_id: aph(3') -> aph(3')-II aph(3')-II APH(3')-II family aminoglycoside O-phosphotransferase hmm_acc: NF032898.1 -> NF032898.2 aph(3')-VIII aminoglycoside O-phosphotransferase APH(3')-VIII hmm_acc: NF033066.0 -> aph(3')-VIIIa aminoglycoside O-phosphotransferase APH(3')-VIIIa hmm_acc: -> NF033066.0 blaCAM CAM family subclass B1 metallo-beta-lactamase hmm_acc: NF033895.1 -> NF033895.2 blaIMI IMI family carbapenem-hydrolyzing class A beta-lactamase hmm_acc: NF000400.2 -> NF000400.3 blaOXA-427_fam OXA-427 family carbapenem-hydrolyzing class D beta-lactamase hmm_acc: NF038217.1 -> NF038217.2 blaOXA-62_fam OXA-62 family carbapenem-hydrolyzing class D beta-lactamase subclass: BETA-LACTAM -> CARBAPENEM blaSPR SPR family subclass B3 metallo-beta-lactamase hmm_acc: NF041137.1 -> NF041137.2 cfr_gen Cfr family 23S rRNA (adenine(2503)-C(8))-methyltransferase hmm_acc: NF000424.3 -> NF000424.4 lsa Lsa family ABC-F type ribosomal protection protein hmm_acc: NF000167.1 -> NF000167.2 merB_gen organomercurial lyase MerB scope: non-reported -> plus mexE multidrug efflux RND transporter periplasmic adaptor subunit MexE hmm_acc: NF000249.1 -> NF045904.1 name: MexE family multidrug efflux RND transporter periplasmic adaptor subunit -> multidrug efflux RND transporter periplasmic adaptor subunit MexE msr Msr family ABC-F type ribosomal protection protein hmm_acc: NF000168.1 -> NF000168.2 stxA1 Shiga toxin Stx1 subunit A hmm_acc: NF033658.1 -> NF033658.2 subclass: STX1 -> stxA1 stxA1a Shiga toxin Stx1a subunit A subclass: STX1A -> stxA1a symbol: stxA1a -> stxA1 stxA1c Shiga toxin Stx1c subunit A subclass: STX1C -> stxA1c symbol: stxA1c -> stxA1 stxA1d Shiga toxin Stx1d subunit A subclass: STX1D -> stxA1d symbol: stxA1d -> stxA1 stxA1e Shiga toxin Stx1e subunit A subclass: STX1E -> stxA1e symbol: stxA1e -> stxA1 stxA2 Shiga toxin Stx2 subunit A subclass: STX2 -> stxA2 stxA2_acd Shiga toxin Stx2 subunit A name: Shiga toxin Stx2 subunit A, a/c/d subtype -> Shiga toxin Stx2 subunit A subclass: STX2 -> stxA2 stxA2_eilk Shiga toxin Stx2 subunit A, e/i/l/k subtype subclass: STX2 -> stxA2 stxA2a Shiga toxin Stx2a subunit A subclass: STX2A -> stxA2a symbol: stxA2a -> stxA2 stxA2b Shiga toxin Stx2b subunit A subclass: STX2B -> stxA2b symbol: stxA2b -> stxA2 stxA2c Shiga toxin Stx2c subunit A subclass: STX2C -> stxA2c symbol: stxA2c -> stxA2 stxA2d Shiga toxin Stx2d subunit A subclass: STX2D -> stxA2d symbol: stxA2d -> stxA2 stxA2e Shiga toxin Stx2e subunit A subclass: STX2E -> stxA2e symbol: stxA2e -> stxA2 stxA2f Shiga toxin Stx2f subunit A subclass: STX2F -> stxA2f symbol: stxA2f -> stxA2 stxA2g Shiga toxin Stx2g subunit A subclass: STX2G -> stxA2g symbol: stxA2g -> stxA2 stxA2h Shiga toxin Stx2h subunit A subclass: STX2H -> stxA2h symbol: stxA2h -> stxA2 stxA2i Shiga toxin Stx2i subunit A subclass: STX2I -> stxA2i symbol: stxA2i -> stxA2 stxA2j Shiga toxin Stx2j subunit A subclass: STX2J -> stxA2j symbol: stxA2j -> stxA2 stxA2k Shiga toxin Stx2k subunit A subclass: STX2K -> stxA2k symbol: stxA2k -> stxA2 stxA2l Shiga toxin Stx2l subunit A subclass: STX2L -> stxA2l symbol: stxA2l -> stxA2 stxA2m Shiga toxin Stx2m subunit A subclass: STX2M -> stxA2m symbol: stxA2m -> stxA2 stxA2n Shiga toxin Stx2n subunit A subclass: STX2N -> stxA2n symbol: stxA2n -> stxA2 stxA2o Shiga toxin Stx2o subunit A subclass: STX2O -> stxA2o symbol: stxA2o -> stxA2 stxB1 Shiga toxin Stx1 subunit B subclass: STX1 -> stxB1 stxB1a Shiga toxin Stx1a subunit B subclass: STX1A -> stxB1a symbol: stxB1a -> stxB1 stxB1c Shiga toxin Stx1c subunit B subclass: STX1C -> stxB1c symbol: stxB1c -> stxB1 stxB1d Shiga toxin Stx1d subunit B subclass: STX1D -> stxB1d symbol: stxB1d -> stxB1 stxB1e Shiga toxin Stx1e subunit B subclass: STX1E -> stxB1e symbol: stxB1e -> stxB1 stxB2 Shiga toxin Stx2 subunit B subclass: STX2 -> stxB2 stxB2a Shiga toxin Stx2a subunit B subclass: STX2A -> stxB2a symbol: stxB2a -> stxB2 stxB2b Shiga toxin Stx2b subunit B subclass: STX2B -> stxB2b symbol: stxB2b -> stxB2 stxB2c Shiga toxin Stx2c subunit B subclass: STX2C -> stxB2c symbol: stxB2c -> stxB2 stxB2d Shiga toxin Stx2d subunit B subclass: STX2D -> stxB2d symbol: stxB2d -> stxB2 stxB2e Shiga toxin Stx2e subunit B subclass: STX2E -> stxB2e symbol: stxB2e -> stxB2 stxB2f Shiga toxin Stx2f subunit B subclass: STX2F -> stxB2f symbol: stxB2f -> stxB2 stxB2g Shiga toxin Stx2g subunit B subclass: STX2G -> stxB2g symbol: stxB2g -> stxB2 stxB2h Shiga toxin Stx2h subunit B subclass: STX2H -> stxB2h symbol: stxB2h -> stxB2 stxB2i Shiga toxin Stx2i subunit B subclass: STX2I -> stxB2i symbol: stxB2i -> stxB2 stxB2j Shiga toxin Stx2j subunit B subclass: STX2J -> stxB2j symbol: stxB2j -> stxB2 stxB2m Shiga toxin Stx2m subunit B subclass: STX2M -> stxB2m symbol: stxB2m -> stxB2 stxB2n Shiga toxin Stx2n subunit B subclass: STX2N -> stxB2n symbol: stxB2n -> stxB2 stxB2o Shiga toxin Stx2o subunit B subclass: STX2O -> stxB2o symbol: stxB2o -> stxB2 vanW-I glycopeptide resistance accessory protein VanW-I parent_node_id: vanW -> AMR vga Vga family ABC-F type ribosomal protection protein hmm_acc: NF000170.1 -> NF000170.2 vga(F) ABC-F type ribosomal protection protein Vga(F) hmm_acc: -> NF045691.1 ---------------------------------------------------------------------- Changes included in 2024-01-31.1 ---------------------------------------------------------------------- This release is in a new database format, so in order to use the latest version of the AMRFinderPlus database (2020-05-04.1) you must upgrade to AMRFinderPlus version 3.12.8. See https://github.com/ncbi/amr/wiki/Upgrading#software-upgrades for information on how to upgrade the AMRFinderPlus software. Because this version is incompatible with AMRFinderPlus databases from previous versions, amrfinder -u must be run once the software update is installed to get the latest version of the database. This update includes two basic changes: - Reference proteins now have stop codons. Input proteins that are not terminated with a '*' character are assumed to have a '*' at the end. - Extended proteins are no longer "EXACT" hits, so the protein names will be that of the parent node for alleles. This means that Previously extended hits that were 100% identical to, but longer than proteins in the database were called with the method "EXACTP" and now they are called "BLASTP". Blast results will still indicate that 100% of the database reference was covered at 100% identity, and you should still see that the "Target length" is longer than the "Reference sequence length". 1. Extended hits to allele sequences that were previously called EXACTP already had the element symbol was one node up the hierarchy (i.e. the gene symbol, not the allele symbol) the "Sequence name" was that of the ALLELE reference, and thus inconsistent with the element symbol assigned. This has been changed. Again, this does not affect previous "Element symbol" calls. 2. In combined protein + nucleotide runs of AMRFinderPlus extended protein sequences with exact matches in the database were ignored and the nucleotide match was taken resulting in an EXACTX match with no protein accession provided. Now the protein match with method BLASTP will be reported. To reiterate, gene symbols should not change. Sequence names will only change if the query is an extended version of a protein 100% identical and completely covering an allele in the database. Other than the database format change database release 2024-01-31.1 includes: - cfaC (AAQ20107.1) was renamed to csuC - Virulence genes for Burkholderia were reviewed and added - A Campylobacter blaOXA-61 promoter mutation that confers carbapenem resistance was added, and blaOXA-143 promoter mutations for Acinetobacter_baumannii were renamed from to add the parent OXA allele number, for example blaOXA_G-42A was renamed to blaOXA-143_G-42A - Multiple ETEC associated virulence factors were added - Clostridium botulinum toxin genes were added - New Clostridioides_difficile, Pseudomonas_aeruginosa, and Escherichia point mutations were added - 212 Pubmed references were added Summary: Total proteins: 8051 Core proteins: 6866 Plus proteins: 1182 AMR proteins: 6912 STRESS proteins: 253 VIRULENCE proteins: 886 PubMed references: 4381 Point mutations: 1290 Point mutation reference sequences: 227 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae, Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes, Vibrio_cholerae, Vibrio_parahaemolyticus, Vibrio_vulnificus HMMs: 730 Updates since release 2023-11-15.1: Proteins added: 116 Core proteins added: 49 Plus proteins added: 67 AMR proteins added: 50 VIRULENCE proteins added: 66 Alleles added: 45 PubMed references added: 212 PubMed references removed: 2 Point mutations added: 38 Point mutations removed 2 Reference Gene Catalog entries changed: 83 Hierarchy nodes added: 81 Hierarchy nodes changed: 1 Added proteins core AMR AMR aac(6')-E141 NG_242278.1 WP_026868862.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E141 blaPEN-H NG_242279.1 WP_029226214.1 PEN-H family class A beta-lactamase erm(B) NG_242280.1 WP_063844598.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) vanY-M NG_242281.1 WP_107309513.1 D-Ala-D-Ala carboxypeptidase VanY-M blaADC-344 NG_242282.1 WP_321981483.1 extended-spectrum class C beta-lactamase ADC-344 blaADC-345 NG_242283.1 WP_321993619.1 extended-spectrum class C beta-lactamase ADC-345 blaADC-346 NG_242284.1 WP_328703054.1 extended-spectrum class C beta-lactamase ADC-346 blaCMY-190 NG_242285.1 WP_328703055.1 class C beta-lactamase CMY-190 blaCTX-M-247 NG_242286.1 WP_328703056.1 extended-spectrum class A beta-lactamase CTX-M-247 blaCTX-M-248 NG_242287.1 WP_121572426.1 extended-spectrum class A beta-lactamase CTX-M-248 blaCTX-M-249 NG_242288.1 WP_328703057.1 extended-spectrum class A beta-lactamase CTX-M-249 blaCTX-M-270 NG_242289.1 WP_322263690.1 extended-spectrum class A beta-lactamase CTX-M-270 blaIMI-10 NG_242290.1 WP_319877346.1 carbapenem-hydrolyzing class A beta-lactamase IMI-10 blaIMP-101 NG_242291.1 WP_328703058.1 subclass B1 metallo-beta-lactamase IMP-101 blaIMP-50 NG_242292.1 WP_319861626.1 subclass B1 metallo-beta-lactamase IMP-50 blaKPC-149 NG_242293.1 WP_328703059.1 carbapenem-hydrolyzing class A beta-lactamase KPC-149 blaKPC-150 NG_242294.1 WP_328703060.1 inhibitor-resistant class A beta-lactamase KPC-150 blaKPC-152 NG_242295.1 WP_328703061.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-152 blaKPC-202 NG_242296.1 WP_328703062.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-202 blaKPC-203 NG_242297.1 WP_321140136.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-203 blaKPC-204 NG_242298.1 WP_265432541.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-204 blaKPC-205 NG_242299.1 WP_322972495.1 inhibitor-resistant class A beta-lactamase KPC-205 blaKPC-206 NG_242300.1 WP_328703063.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-206 blaKPC-207 NG_242301.1 WP_328703064.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-207 blaKPC-208 NG_242302.1 WP_328703065.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-208 blaOXA-1167 NG_242303.1 WP_328703066.1 OXA-48 family class D beta-lactamase OXA-1167 blaOXA-1224 NG_242304.1 WP_101663562.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1224 blaOXA-1225 NG_242305.1 WP_328703067.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1225 blaPDC-577 NG_242306.1 WP_328703068.1 inhibitor-resistant extended-spectrum class C beta-lactamase PDC-577 blaPDC-578 NG_242307.1 WP_328703069.1 class C beta-lactamase PDC-578 blaPDC-579 NG_242308.1 WP_328703070.1 class C beta-lactamase PDC-579 blaPDC-580 NG_242309.1 WP_328703071.1 class C beta-lactamase PDC-580 blaPDC-581 NG_242310.1 WP_328703072.1 class C beta-lactamase PDC-581 blaSHV-175 NG_242311.1 WP_200525730.1 class A beta-lactamase SHV-175 blaSHV-233 NG_242312.1 WP_328703073.1 inhibitor-resistant class A beta-lactamase SHV-233 blaSHV-234 NG_242313.1 WP_328703074.1 inhibitor-resistant class A beta-lactamase SHV-234 blaSHV-235 NG_242314.1 WP_328703075.1 class A beta-lactamase SHV-235 blaSHV-236 NG_242315.1 WP_328703076.1 class A beta-lactamase SHV-236 blaSHV-237 NG_242316.1 WP_328703077.1 class A beta-lactamase SHV-237 blaSHV-238 NG_242317.1 WP_328703078.1 class A beta-lactamase SHV-238 blaSHV-239 NG_242318.1 WP_328703079.1 inhibitor-resistant class A beta-lactamase SHV-239 blaSHV-240 NG_242319.1 WP_064173135.1 inhibitor-resistant class A beta-lactamase SHV-240 blaSHV-241 NG_242320.1 WP_328703080.1 inhibitor-resistant class A beta-lactamase SHV-241 blaSHV-242 NG_242321.1 WP_265929472.1 inhibitor-resistant class A beta-lactamase SHV-242 blaSHV-243 NG_242322.1 WP_328703081.1 class A beta-lactamase SHV-243 blaVEB-32 NG_242323.1 WP_073350313.1 extended-spectrum class A beta-lactamase VEB-32 blaVEB-33 NG_242324.1 WP_328703082.1 extended-spectrum class A beta-lactamase VEB-33 mcr-1.37 NG_242325.1 WP_114429521.1 phosphoethanolamine--lipid A transferase MCR-1.37 qnrB98 NG_242326.1 WP_149691965.1 quinolone resistance pentapeptide repeat protein QnrB98 plus AMR AMR nimB-Cd FN545816.1 CBE03766.1 putative 5-nitroimidazole reductase NimB-Cd plus VIRULENCE VIRULENCE bont_F6 M92906.1 AAA23263.1 botulinum neurotoxin subtype F6 cssA U04844.1 AAC45093.1 CS6 fimbrial subunit A CssA cseA AF145205.1 AAD30557.1 C22 fimbrial major subunit CseA cswA AY009096.1 AAK09047.1 CS12 fimbrial major subunit CswA csaB AF296132.1 AAK97135.1 CS4 pilus major pilin CsaB csnA AF438155.1 AAL31637.1 CS20 fimbrial major subunit CsnA fotA AF335469.1 AAO73846.1 CS18 fimbrial major subunit FotA csdA AY288101.1 AAQ19775.1 CS19 fimbria major subunit CsdA cosA AY513487.1 AAS89773.1 PCF071 fimbrial major subunit CosA csbA AY515609.1 AAS89777.1 CS17 fimbrial major subunit CsbA cooA AY536429.1 AAT07441.1 CS1 fimbrial major subunit CooA bont_B3 EF028400.1 ABM73977.1 botulinum neurotoxin subtype B3 bont_E3 EF028403.1 ABM73980.1 botulinum neurotoxin subtype E3 bont_E2 EF028404.1 ABM73981.1 botulinum neurotoxin subtype E2 bont_B4 EF051570.1 ABM73987.1 botulinum neurotoxin subtype B4 bont_DC EF378947.1 ABP48747.1 botulinum neurotoxin subtype DC bont_F1 CP000728.1 ABS41202.1 botulinum neurotoxin subtype F1 bont_B1 CP000940.1 ACA46990.1 botulinum neurotoxin subtype B1 bont_A3 CP000963.1 ACA57525.1 botulinum neurotoxin subtype A3 bont_A5 EU679004.1 ACG50065.1 botulinum neurotoxin subtype A5 bont_B5 CP001081.1 ACQ51206.1 botulinum neurotoxin subtype B5 bont_A4 CP001081.1 ACQ51417.1 botulinum neurotoxin subtype A4 bont_A6 FJ981696.1 ACW83608.1 botulinum neurotoxin subtype A6 bont_F5 GU213212.1 ADA79560.1 botulinum neurotoxin subtype F5 bont_F4 GU213221.1 ADA79569.1 botulinum neurotoxin subtype F4 bont_F3 GU213227.1 ADA79575.1 botulinum neurotoxin subtype F3 bont_F7 HM746656.1 ADK48765.1 botulinum neurotoxin subtype F7 bont_E7 JN695729.1 AER11391.1 botulinum neurotoxin subtype E7 bont_E8 JN695730.1 AER11392.1 botulinum neurotoxin subtype E8 aalE JQ434477.1 AFD29291.1 CS23 fimbrial major subunit AalE bont_B7 JQ354985.1 AFD33678.1 botulinum neurotoxin subtype B7 bonA JX173632.1 AFN27480.1 bongkrekic acid type I polyketide synthase BonA bont_B8 JQ964806.1 AFN61309.1 botulinum neurotoxin subtype B8 bont_A7 JQ954969.1 AFV13854.1 botulinum neurotoxin subtype A7 bont_E9 JX424534.1 AFV91339.1 botulinum neurotoxin subtype E9 bont_E12 KF929215.1 AHK10119.1 botulinum neurotoxin subtype E12 bont_E11 KF861879.1 AII82289.1 botulinum neurotoxin subtype E11 bont_E10 KF861920.1 AII82330.1 botulinum neurotoxin subtype E10 bont_A8 KM233166.1 AJA05787.1 botulinum neurotoxin subtype A8 bont_CD D49440.1 BAA08418.1 botulinum neurotoxin subtype CD bc2l D63903.1 BAA09942.1 C2 toxin component I bont_C1 D90210.1 BAA14235.1 botulinum neurotoxin subtype C1 bc2h D88982.1 BAA32537.1 C2 toxin component II bont_E5 AB037704.1 BAB03512.1 botulinum neurotoxin subtype E5 bont_E4 AB088207.1 BAC05434.1 botulinum neurotoxin subtype E4 bont_B2 AB084152.1 BAC22064.1 botulinum neurotoxin subtype B2 bont_B6 AB302852.1 BAF91946.1 botulinum neurotoxin subtype B6 bont_X AP014696.1 BAQ12790.1 botulinum neurotoxin type X cfsA AJ224079.2 CAA11820.1 CS5 fimbrial major subunit CsfA cstB X16944.1 CAA34816.1 CS3 fimbrial usher protein CstB c3bot1 X59040.1 CAA41768.1 C3 toxin bont_E1 X62089.1 CAA43999.1 botulinum neurotoxin subtype E1 cshE X71971.1 CAA50789.1 CS13 fimbrial major subunit CshE bont_A2 X73423.1 CAA51824.1 botulinum neurotoxin subtype A2 bont_F2 Y13631.1 CAA73972.1 botulinum neurotoxin subtype F2 cotA Z47800.1 CAA87761.1 CS2 fimbrial major subunit CotA csvA LR882979.1 CAD5989151.1 CS7 fimbrial major subunit CsvA bont_A1 AM412317.1 CAL82360.1 botulinum neurotoxin subtype A1 bont_E6 AM695752.1 CAM91125.1 botulinum neurotoxin subtype E6 cblA AM747721.1 CAR56625.1 cable pilus major pilin CblA c3bot2 ABDQ01000009.1 EDS77074.1 C3 toxin bont_F8 AUZC01000009.1 KEJ01913.1 botulinum neurotoxin subtype F8 bont_H JSCF01000006.1 KGO15617.1 botulinum neurotoxin type H bont_G AYSO01000020.1 KIE44899.1 botulinum neurotoxin type G crsA LGMS01000054.1 OKT93637.1 CS26 fimbrial major subunit CrsA fanC CP026930.2 QHF70768.1 F5 fimbrial major subunit protein FanC Added point mutations core AMR POINT ampD_E108STOP CARBAPENEM Pseudomonas_aeruginosa blaOXA-143_A-14G CARBAPENEM Acinetobacter_baumannii blaOXA-143_G-42A CARBAPENEM Acinetobacter_baumannii blaOXA-61_G-57T CARBAPENEM Campylobacter mexR_Q31STOP CARBAPENEM Pseudomonas_aeruginosa mexR_Q49STOP CARBAPENEM Pseudomonas_aeruginosa mexZ_E8STOP CARBAPENEM Pseudomonas_aeruginosa mexZ_Q103STOP CARBAPENEM Pseudomonas_aeruginosa mexZ_Q134STOP CARBAPENEM Pseudomonas_aeruginosa mexZ_Q69STOP CARBAPENEM Pseudomonas_aeruginosa mexZ_Q95STOP CARBAPENEM Pseudomonas_aeruginosa mexZ_W167STOP CARBAPENEM Pseudomonas_aeruginosa mreE_A694T CEPHALOSPORIN Clostridioides_difficile mreE_A694V CEPHALOSPORIN Clostridioides_difficile mreE_A778V CEPHALOSPORIN Clostridioides_difficile mreE_A795L CEPHALOSPORIN Clostridioides_difficile mreE_A795V CEPHALOSPORIN Clostridioides_difficile mreE_M496V CEPHALOSPORIN Clostridioides_difficile mreE_V497L CEPHALOSPORIN Clostridioides_difficile mreE_Y721C CEPHALOSPORIN Clostridioides_difficile mreE_Y721S CEPHALOSPORIN Clostridioides_difficile nalD_Q114STOP CARBAPENEM Pseudomonas_aeruginosa oprD_E140STOP CARBAPENEM Pseudomonas_aeruginosa oprD_E185STOP CARBAPENEM Pseudomonas_aeruginosa oprD_E32STOP CARBAPENEM Pseudomonas_aeruginosa oprD_E386STOP CARBAPENEM Pseudomonas_aeruginosa oprD_Q158STOP CARBAPENEM Pseudomonas_aeruginosa oprD_Q164STOP CARBAPENEM Pseudomonas_aeruginosa oprD_Q327STOP CARBAPENEM Pseudomonas_aeruginosa oprD_Q415STOP CARBAPENEM Pseudomonas_aeruginosa oprD_Q424STOP CARBAPENEM Pseudomonas_aeruginosa oprD_Q429STOP CARBAPENEM Pseudomonas_aeruginosa oprD_S278P CARBAPENEM Pseudomonas_aeruginosa oprD_V359L CARBAPENEM Pseudomonas_aeruginosa oprD_W417STOP CARBAPENEM Pseudomonas_aeruginosa oprD_W6STOP CARBAPENEM Pseudomonas_aeruginosa oprD_Y196STOP CARBAPENEM Pseudomonas_aeruginosa rpoB_Q517QDQ RIFAMPIN Escherichia Removed proteins Removed point mutations core AMR POINT blaOXA_A-14G CARBAPENEM Acinetobacter_baumannii blaOXA_G-42A CARBAPENEM Acinetobacter_baumannii Changed reference gene catalog records cfaC AAC41416.1 pubmed_reference: -> 25596032 csuC AAQ20107.1 gene_family: cfaC -> csuC hierarchy_node: cfaC -> csuC product_name: CFA/I pilus usher protein CfaC -> CS14 pilus usher protein CsuC 16S_A1055G NC_000913.3 pubmed_reference: -> 16269538 16S_A1408G NC_000913.3 pubmed_reference: -> 11502507 16S_A1499G NC_000913.3 pubmed_reference: -> 16269538 16S_A1519C NC_000913.3 pubmed_reference: -> 10512710 16S_A1519G NC_000913.3 pubmed_reference: -> 10512710 16S_A1519T NC_000913.3 pubmed_reference: -> 10512710 16S_A523C NC_000913.3 pubmed_reference: -> 3054810 16S_A794G NC_000913.3 pubmed_reference: -> 10512710 16S_A794T NC_000913.3 pubmed_reference: -> 10512710 16S_A964G NC_000913.3 pubmed_reference: -> 16269538 16S_C1054T NC_000913.3 pubmed_reference: -> 16269538 16S_C1066T NC_000913.3 pubmed_reference: -> 8127669 16S_C1192T NC_000913.3 pubmed_reference: -> 6330677 16S_C528T NC_000913.3 pubmed_reference: -> 16269538 16S_G1053A NC_000913.3 pubmed_reference: -> 16269538 16S_G1058C NC_000913.3 pubmed_reference: -> 9661007 16S_G1064A NC_000913.3 pubmed_reference: -> 8127669 16S_G1064C NC_000913.3 pubmed_reference: -> 8127669 16S_G1064T NC_000913.3 pubmed_reference: -> 8127669 16S_G1068A NC_000913.3 pubmed_reference: -> 16269538 16S_G527T NC_000913.3 pubmed_reference: -> 16269538 16S_G926A NC_000913.3 pubmed_reference: -> 10512710 16S_G926C NC_000913.3 pubmed_reference: -> 10512710 16S_G926T NC_000913.3 pubmed_reference: -> 10512710 23S_C2611T NC_004431.1 pubmed_reference: -> 1569089 23S_G2032C NC_004431.1 pubmed_reference: -> 10986233 23S_G2057A NC_004431.1 pubmed_reference: -> 3886627 23S_G2447T NC_004431.1 pubmed_reference: -> 10986233 23S_T754A NC_004431.1 pubmed_reference: -> 10027979 blaKPC-41 WP_148044419.1 pubmed_reference: 31527032,37255469 -> 31527032,35416703,37255469 blaKPC-93 WP_243939160.1 product_name: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-93 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-93 pubmed_reference: -> 35416703 subclass: CARBAPENEM -> CEPHALOSPORIN blaSHV-132 WP_063864620.1 product_name: class A beta-lactamase SHV-132 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-132 blaVIM-1 WP_013263789.1 pubmed_reference: 10390207,18804966,37255469 -> 10390207,18804966,37255469,38197500 blaVIM-19 WP_032492472.1 pubmed_reference: 19917750 -> 19917750,38197500 blaVIM-29 WP_060589395.1 pubmed_reference: 23954421 -> 23954421,38197500 blaVIM-4 WP_032492008.1 pubmed_reference: 12435718 -> 12435718,38197500 blaVIM-86 WP_274293093.1 pubmed_reference: -> 38197500 fabI_F203A WP_000506490.1 pubmed_reference: -> 27577999 fabI_F203C WP_000506490.1 pubmed_reference: -> 27577999 fabI_F203L WP_000506490.1 pubmed_reference: -> 27577999 fabI_G93A WP_000506490.1 pubmed_reference: -> 27577999 fabI_G93S WP_000506490.1 pubmed_reference: -> 27577999 fabI_G93V WP_000506490.1 pubmed_reference: -> 27577999 ftsI_F533L WP_003094139.1 pubmed_reference: 21135211,32071060 -> 21135211,32071060,37823665 gyrA_A70T WP_002857904.1 pubmed_reference: -> 8384814 gyrA_D85Y WP_002857904.1 pubmed_reference: -> 18031331 gyrA_D90A WP_002857904.1 pubmed_reference: -> 8384814 gyrA_D90T WP_002857904.1 pubmed_reference: -> 8384814 gyrA_S97P WP_001281271.1 pubmed_reference: 27559761 -> 27559761,29091182 mcr-9.1 AYW01299.1 pubmed_reference: 31064835,32513803 -> 31064835,32513803,38031909 nfsA_K141STOP WP_089631889.1 pubmed_reference: -> 26552976 nfsA_Q44STOP WP_089631889.1 pubmed_reference: -> 26552976 nfsA_R133S WP_089631889.1 pubmed_reference: -> 26552976 nfsA_R15C WP_089631889.1 pubmed_reference: -> 18544599 nfsA_R203C WP_089631889.1 pubmed_reference: -> 18544599 nfsA_R203L WP_089631889.1 pubmed_reference: -> 18544599 nfsA_S33R WP_089631889.1 pubmed_reference: -> 18544599 oprD_Q142STOP WP_003112576.1 pubmed_reference: 27736752,29681898 -> 27736752,29681898,37823665,37823665 oprD_S251STOP WP_003112576.1 pubmed_reference: 31570397 -> 31570397,37823665 oprD_W138STOP WP_003112576.1 pubmed_reference: 27736752 -> 27736752,37823665 oprD_W277STOP WP_003112576.1 pubmed_reference: 26729493 -> 26729493,37823665 oprD_W339STOP WP_003112576.1 pubmed_reference: 35638817 -> 35638817,37823665 oprD_W65STOP WP_003112576.1 pubmed_reference: 35638817 -> 35638817,37823665 parC_A108T WP_001281881.1 pubmed_reference: -> 12523629,18500921 parC_A85T WP_001281881.1 pubmed_reference: -> 27620866 parC_D111H WP_001281881.1 pubmed_reference: -> 27620866 parC_E84A WP_001281881.1 pubmed_reference: -> 20638608,12654733 parC_F60I WP_001281881.1 pubmed_reference: -> 18500921 parC_F60L WP_001281881.1 pubmed_reference: -> 18500921 parC_S129P WP_001281881.1 pubmed_reference: -> 27620866 parC_S80L WP_001281881.1 pubmed_reference: -> 8524852 rpoB_H526Y WP_000263098.1 pubmed_reference: -> 3050121 rpoB_L533P WP_000263098.1 pubmed_reference: -> 3050121 rpoB_Q513L WP_000263098.1 pubmed_reference: -> 3050121 rpoB_Q513P WP_000263098.1 pubmed_reference: -> 3050121 rpoB_R529C WP_000263098.1 pubmed_reference: -> 3050121 rpoB_R529S WP_000263098.1 pubmed_reference: -> 3050121 rpoB_R687H WP_000263098.1 pubmed_reference: -> 3050121 rpoB_S531F WP_000263098.1 pubmed_reference: -> 3050121 rpoB_T563P WP_000263098.1 pubmed_reference: -> 3050121 rpoB_V146F WP_000263098.1 pubmed_reference: -> 3050121 Hierarchy nodes added core AMR AMR aac(6')_E141 aac(6')-E141 aminoglycoside 6'-N-acetyltransferase AAC(6')-E141 blaCIM blaCIB NF041441.1 CIM family subclass B1 metallo-beta-lactamase blaPEN-H blaPEN-H PEN-H family class A beta-lactamase vanY-M vanY-M D-Ala-D-Ala carboxypeptidase VanY-M non-reported VIRULENCE VIRULENCE VIRULENCE_Burk VIRULENCE_Cbot bont plus AMR AMR nimB-Cd nimB-Cd putative 5-nitroimidazole reductase NimB-Cd plus VIRULENCE VIRULENCE aalE aalE CS23 fimbrial major subunit AalE bc2h bc2h C2 toxin component II bc2l bc2l C2 toxin component I bonA bonA bongkrekic acid type I polyketide synthase BonA bont_A bont_A botulinum neurotoxin type A bont_A1 bont_A1 botulinum neurotoxin subtype A1 bont_A2 bont_A2 botulinum neurotoxin subtype A2 bont_A3 bont_A3 botulinum neurotoxin subtype A3 bont_A4 bont_A4 botulinum neurotoxin subtype A4 bont_A5 bont_A5 botulinum neurotoxin subtype A5 bont_A6 bont_A6 botulinum neurotoxin subtype A6 bont_A7 bont_A7 botulinum neurotoxin subtype A7 bont_A8 bont_A8 botulinum neurotoxin subtype A8 bont_B bont_B botulinum neurotoxin type B bont_B1 bont_B1 botulinum neurotoxin subtype B1 bont_B2 bont_B2 botulinum neurotoxin subtype B2 bont_B3 bont_B3 botulinum neurotoxin subtype B3 bont_B4 bont_B4 botulinum neurotoxin subtype B4 bont_B5 bont_B5 botulinum neurotoxin subtype B5 bont_B6 bont_B6 botulinum neurotoxin subtype B6 bont_B7 bont_B7 botulinum neurotoxin subtype B7 bont_B8 bont_B8 botulinum neurotoxin subtype B8 bont_C bont_C botulinum neurotoxin type C bont_C1 bont_C1 botulinum neurotoxin subtype C1 bont_CD bont_CD botulinum neurotoxin subtype CD bont_D bont_D botulinum neurotoxin type D bont_DC bont_DC botulinum neurotoxin subtype DC bont_E bont_E botulinum neurotoxin type E bont_E1 bont_E1 botulinum neurotoxin subtype E1 bont_E10 bont_E10 botulinum neurotoxin subtype E10 bont_E11 bont_E11 botulinum neurotoxin subtype E11 bont_E12 bont_E12 botulinum neurotoxin subtype E12 bont_E2 bont_E2 botulinum neurotoxin subtype E2 bont_E3 bont_E3 botulinum neurotoxin subtype E3 bont_E4 bont_E4 botulinum neurotoxin subtype E4 bont_E5 bont_E5 botulinum neurotoxin subtype E5 bont_E6 bont_E6 botulinum neurotoxin subtype E6 bont_E7 bont_E7 botulinum neurotoxin subtype E7 bont_E8 bont_E8 botulinum neurotoxin subtype E8 bont_E9 bont_E9 botulinum neurotoxin subtype E9 bont_F bont_F botulinum neurotoxin type F bont_F1 bont_F1 botulinum neurotoxin subtype F1 bont_F2 bont_F2 botulinum neurotoxin subtype F2 bont_F3 bont_F3 botulinum neurotoxin subtype F3 bont_F4 bont_F4 botulinum neurotoxin subtype F4 bont_F5 bont_F5 botulinum neurotoxin subtype F5 bont_F6 bont_F6 botulinum neurotoxin subtype F6 bont_F7 bont_F7 botulinum neurotoxin subtype F7 bont_F8 bont_F8 botulinum neurotoxin subtype F8 bont_G bont_G botulinum neurotoxin type G bont_H bont_H botulinum neurotoxin type H bont_X bont_X botulinum neurotoxin type X c3bot1 c3bot1 C3 toxin c3bot2 c3bot2 C3 toxin cblA_Bc cblA cable pilus major pilin CblA cfsA cfsA CS5 fimbrial major subunit CsfA cooA cooA CS1 fimbrial major subunit CooA cosA cosA PCF071 fimbrial major subunit CosA cotA cotA CS2 fimbrial major subunit CotA crsA crsA CS26 fimbrial major subunit CrsA csaB csaB CS4 pilus major pilin CsaB csbA csbA CS17 fimbrial major subunit CsbA csdA csdA CS19 fimbria major subunit CsdA cseA cseA C22 fimbrial major subunit CseA cshE cshE CS13 fimbrial major subunit CshE csnA csnA CS20 fimbrial major subunit CsnA cssA cssA CS6 fimbrial subunit A CssA cstB cstB CS3 fimbrial usher protein CstB csuC csuC CS14 pilus usher protein CsuC csvA csvA CS7 fimbrial major subunit CsvA cswA cswA CS12 fimbrial major subunit CswA fanC fanC F5 fimbrial major subunit protein FanC fotA fotA CS18 fimbrial major subunit FotA Hierarchy nodes removed Changed Hierarchy Nodes erm(G) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(G) hmm_acc: -> NF045543.1 ---------------------------------------------------------------------- Changes included in 2023-11-15.1 ---------------------------------------------------------------------- Overview: - 19 new point mutations (and two new --organism options) for Vibrio cholerae, Vibrio parahaemolyticus, Vibrio vulnificus, and Klebsiella pneumoniae - A reorganization and 20 new aminoglycoside modifying enzyme (AME) genes and HMMs based on curator review and Lund et al., 2023 (PMID: 37537271). This includes a new non-reportable HMM and genes to suppress reporting of some cryptic AMEs that would otherwise be identified by new higher-level HMMs. - Revised subclasses and new citations for some previously included AME genes - 304 new PubMed references added - Improved dfrB HMM - Additional stx subunit sequences based on Lindsey et al. 2023 (PMID: 37894219). Note that AMRFinderPlus identifies stx proteins and provides some subunit type information, but stx type calling requires a more complex algorithm and simultaneous investigation of both genes. We are working with collaborators towards an algorithm, manuscript, and software to accurately determine stx type. - Two new beta-lactamase genes with allele assignment: blaCDA and blaYOC - tetA(D) was reassigned to the tet(59) node Summary: Total proteins: 7935 Core proteins: 6817 Plus proteins: 1115 AMR proteins: 6862 STRESS proteins: 253 VIRULENCE proteins: 820 PubMed references: 4170 Point mutations: 1254 Point mutation reference sequences: 225 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae, Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes, Vibrio_cholerae, Vibrio_parahaemolyticus, Vibrio_vulnificus HMMs: 728 Updates since release 2023-09-26.1: Proteins added: 45 Core proteins added: 39 Plus proteins added: 4 AMR proteins added: 43 VIRULENCE proteins added: 2 Alleles added: 21 PubMed references added: 304 Point mutations added: 19 Added organism options: Vibrio_parahaemolyticus, Vibrio_vulnificus Reference Gene Catalog entries changed: 276 Hierarchy nodes added: 30 Hierarchy nodes changed: 36 Added proteins core AMR AMR aac(6')-E606 NG_242167.1 WP_000405752.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E606 aac(6')-E657 NG_242169.1 WP_024566461.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E657 aac(2')-I(A267) NG_242157.1 WP_025297907.1 aminoglycoside N-acetyltransferase AAC(2')-I(A267) aac(3)-C1264 NG_242158.1 WP_034000523.1 aminoglycoside N-acetyltransferase AAC(3)-C1264 aph(3')-H48 NG_242174.1 WP_034024097.1 aminoglycoside O-phosphotransferase APH(3')-H48 aac(3)-C322 NG_242159.1 WP_044061792.1 aminoglycoside N-acetyltransferase AAC(3)-C322 aac(6')-E550 NG_242165.1 WP_058699631.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E550 aac(6')-D292 NG_242160.1 WP_058878818.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-D292 aac(6')-E111 NG_242162.1 WP_065217783.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E111 aac(6')-E963 NG_242170.1 WP_104467712.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E963 aac(6')-E526 NG_242164.1 WP_128470137.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E526 aac(6')-F72 NG_242172.1 WP_172693600.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-F72 aph(2'')-G141 NG_242173.1 WP_185250308.1 aminoglycoside O-phosphotransferase APH(2')-G141 aph(3')-I(H957) NG_242176.1 WP_216562158.1 aminoglycoside O-phosphotransferase APH(3')-I(H957) aac(6')-D42 NG_242161.1 WP_318245537.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-D42 aac(6')-E449 NG_242163.1 WP_318245538.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E449 aac(6')-E553 NG_242166.1 WP_318245539.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E553 aac(6')-E64 NG_242168.1 WP_318245540.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-E64 aac(6')-F309 NG_242171.1 WP_318245541.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-F309 aph(3')-H510 NG_242175.1 WP_318245542.1 aminoglycoside O-phosphotransferase APH(3')-H510 blaCAM-2 NG_242177.1 WP_318245543.1 subclass B1 metallo-beta-lactamase CAM-2 blaCDA-1 NG_242178.1 WP_253282916.1 class C beta-lactamase CDA-1 blaCTX-M-268 NG_242179.1 WP_318245544.1 extended-spectrum class A beta-lactamase CTX-M-268 blaCTX-M-269 NG_242180.1 WP_318245545.1 extended-spectrum class A beta-lactamase CTX-M-269 blaDHA-33 NG_242181.1 WP_318245546.1 class C beta-lactamase DHA-33 blaKPC-137 NG_242182.1 WP_318245547.1 inhibitor-resistant class A beta-lactamase KPC-137 blaKPC-168 NG_242183.1 WP_318245548.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-168 blaKPC-176 NG_242184.1 WP_318245549.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-176 blaKPC-193 NG_242185.1 WP_318245550.1 class A beta-lactamase KPC-193 blaKPC-194 NG_242186.1 WP_318245551.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-194 blaKPC-195 NG_242187.1 WP_318245552.1 carbapenem-hydrolyzing class A beta-lactamase KPC-195 blaKPC-196 NG_242188.1 WP_318245553.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-196 blaKPC-197 NG_242189.1 WP_316472302.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-197 blaKPC-201 NG_242190.1 WP_305449896.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-201 blaOXA-105 NG_242191.1 WP_265760908.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-105 blaOXA-1223 NG_242192.1 WP_318245554.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1223 blaYOC-1 NG_242193.1 WP_167809787.1 class C beta-lactamase YOC-1 dfrB10 NG_242194.1 WP_172688537.1 trimethoprim-resistant dihydrofolate reductase DfrB10 dfrB11 NG_242195.1 WP_318245555.1 trimethoprim-resistant dihydrofolate reductase DfrB11 non-reported AMR AMR aac(6')-Iaa AE006468.2 AAL20537.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaa aac(6')-Iy AF144880.1 AAF03531.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-Iy plus AMR AMR cplR CP010905.2 AJP12342.1 ABC-F type ribosomal protection protein CplR cplR CP009225.1 AKC61310.1 ABC-F type ribosomal protection protein CplR plus VIRULENCE VIRULENCE stxA2n CP113094.1 WAK61649.1 Shiga toxin Stx2n subunit A stxA2m OQ054797.1 WGO76391.1 Shiga toxin Stx2m subunit A Added point mutations core AMR POINT ampD_H157Y CEPHALOSPORIN/TAZOBACTAM Pseudomonas_aeruginosa cirA_E133STOP CEFIDEROCOL Klebsiella_pneumoniae ftsI_L367Q CEFTAZIDIME-AVIBACTAM Klebsiella_pneumoniae gyrA_D87N QUINOLONE Vibrio_cholerae gyrA_S83F QUINOLONE Vibrio_parahaemolyticus gyrA_S83I QUINOLONE Vibrio_cholerae gyrA_S83I QUINOLONE Vibrio_parahaemolyticus gyrA_S83I QUINOLONE Vibrio_vulnificus gyrA_S83R QUINOLONE Vibrio_vulnificus lamB_R134P CEFTAZIDIME-AVIBACTAM Klebsiella_pneumoniae lamB_R374S CEFTAZIDIME-AVIBACTAM Klebsiella_pneumoniae parC_S85F QUINOLONE Vibrio_parahaemolyticus parC_S85I QUINOLONE Vibrio_cholerae parC_S85L QUINOLONE Vibrio_cholerae parC_S85L QUINOLONE Vibrio_parahaemolyticus parC_S85L QUINOLONE Vibrio_vulnificus parE_D420N QUINOLONE Vibrio_cholerae parE_P439S QUINOLONE Vibrio_cholerae phoQ_V24G COLISTIN Klebsiella_pneumoniae Changed reference gene catalog records ariR AAC74250.1 synonyms: -> ymgB lpfA-O113 AAP18950.1 gene_family: lpfA -> lpfA-O113 lpfA-O113 AAT76975.1 gene_family: lpfA -> lpfA-O113 lpfA-O113 ACB16424.1 gene_family: lpfA -> lpfA-O113 stxB1e AHJ80154.1 class: -> STX1 subclass: -> STX1E stxA1e AHJ80155.1 class: -> STX1 subclass: -> STX1E stxB2l CAP17610.1 gene_family: stxB2e -> stxB2l hierarchy_node: stxB2e -> stxB2l product_name: Shiga toxin Stx2e subunit B -> Shiga toxin Stx2l subunit B subclass: STX2E -> STX2L lpfA-O113 CAV00812.1 gene_family: lpfA -> lpfA-O113 stxA2o EEV0948227.1 class: -> STX2 subclass: -> STX2O stxB2o EEV0948228.1 class: -> STX2 subclass: -> STX2O stxB2n WAK53219.1 class: -> STX2 subclass: -> STX2N stxB2m WGO76392.1 class: -> STX2 subclass: -> STX2M dfrA19 WP_000019304.1 pubmed_reference: -> 19075060 cmlA1 WP_000095725.1 pubmed_reference: -> 17283193 vanX-A WP_000402347.1 pubmed_reference: -> 17021204 msr(A) WP_000438874.1 pubmed_reference: -> 17986343 tet(K) WP_000492284.1 pubmed_reference: -> 16517273 vanZ-A WP_000516404.1 pubmed_reference: -> 17021204 tet(M) WP_000691737.1 pubmed_reference: -> 19948800 blaZ WP_000733281.1 pubmed_reference: -> 17986343 blaZ WP_000733287.1 pubmed_reference: -> 17986343 erm(C) WP_001003260.1 pubmed_reference: -> 16517273 cfr WP_001010505.1 pubmed_reference: 16801432 -> 15471995,16801432 tet(59) WP_001031679.1 gene_family: tetA(D) -> tet(59) hierarchy_node: tetA(D) -> tet(59) product_name: Tet(D)-related tetracycline efflux MFS transporter -> tetracycline efflux MFS transporter Tet(59) synonyms: -> tet59,tetA(D) vanH-A WP_001059542.1 pubmed_reference: -> 17021204 tet(38) WP_001100289.1 pubmed_reference: -> 19948800 tet(38) WP_001100300.1 pubmed_reference: -> 17986343 aac(3)-IIe WP_002063884.1 pubmed_reference: -> 12726770 ant(6)-Ia WP_002294505.1 pubmed_reference: -> 19603075 vanH-B WP_002317268.1 pubmed_reference: -> 19029325 lsa(A) WP_002398829.1 pubmed_reference: -> 15616272 catA WP_002403315.1 pubmed_reference: 11257023 -> 11257023,11735367 lsa(A) WP_002411322.1 pubmed_reference: -> 15616272 aad9 WP_002578722.1 pubmed_reference: -> 15917546 tet(32) WP_002602099.1 pubmed_reference: -> 17178791 tet(O/M/O) WP_002872163.1 pubmed_reference: -> 15470128 tet(O) WP_002909882.1 pubmed_reference: -> 15917546 mgt WP_003972830.1 pubmed_reference: -> 15984838 tet(W) WP_004217777.1 pubmed_reference: -> 18614524 aph(3')-IX WP_004861468.1 product_name: APH(3') family aminoglycoside O-phosphotransferase -> aminoglycoside O-phosphotransferase APH(3')-IX str WP_010711054.1 pubmed_reference: 11257023 -> 11257023,11735367 aadA7 WP_010794258.1 pubmed_reference: -> 17158944,18391044 vanW-B WP_010815683.1 pubmed_reference: -> 19029325 bla WP_011053164.1 pubmed_reference: -> 15561870 lsa(B) WP_011133547.1 pubmed_reference: -> 15471995 tet(O) WP_011187228.1 pubmed_reference: -> 15470128 aph(3')-Ib WP_011205810.1 pubmed_reference: -> 26604259 sul2 WP_011270126.1 pubmed_reference: -> 18190962 sul2 WP_011270145.1 pubmed_reference: -> 18190962 aac(3)-I WP_011270148.1 pubmed_reference: -> 15995187 bla WP_011270171.1 pubmed_reference: -> 15995187 sul2 WP_011453052.1 pubmed_reference: -> 16670108 floR WP_011453054.1 pubmed_reference: -> 16670108 aph(3')-IIc WP_012479999.1 pubmed_reference: -> 18419807 aph(6) WP_012480135.1 pubmed_reference: -> 18419807 aac(6')-Iz WP_012481011.1 pubmed_reference: -> 18419807 vanS-B WP_012579101.1 pubmed_reference: -> 19029325 vanX-B WP_012579102.1 pubmed_reference: -> 19029325 tet(O) WP_012669445.1 pubmed_reference: -> 16436729 aph(3')-Ia WP_012695470.1 pubmed_reference: -> 19075060 arr WP_012695486.1 pubmed_reference: -> 19921331 tet(O) WP_012775603.1 pubmed_reference: -> 19603075 tet(B) WP_012881330.1 pubmed_reference: -> 16436729 mef(A) WP_014636304.1 pubmed_reference: -> 19258262 tet(40) WP_015573055.1 pubmed_reference: -> 15728946 tet(O/32/O) WP_015573056.1 pubmed_reference: 11600392 -> 11600392,15728946 sul1 WP_019727244.1 pubmed_reference: -> 17158944,18391044 vanH-D WP_023043160.1 pubmed_reference: -> 17000737 vanS-D WP_028530133.1 pubmed_reference: -> 17724150 vanD WP_028530135.1 pubmed_reference: -> 17724150 vanX-D WP_028530136.1 pubmed_reference: -> 17724150 ere(A) WP_032084014.1 pubmed_reference: -> 19921331 aadA2 WP_032490336.1 pubmed_reference: -> 16451182,16785718 sul1 WP_032490794.1 pubmed_reference: -> 12654659 catA2 WP_032490795.1 pubmed_reference: -> 12654659 ant(6)-Ia WP_032491779.1 pubmed_reference: -> 17021204 aph(3')-IIIa WP_032491780.1 pubmed_reference: -> 17021204 aadA1 WP_032491959.1 pubmed_reference: -> 17698627 aadA2 WP_032491964.1 pubmed_reference: -> 17698627 sul1 WP_032491966.1 pubmed_reference: -> 17698627 tet(W) WP_033493020.1 pubmed_reference: -> 18614524 tet(M) WP_041160408.1 pubmed_reference: -> 16565156 tet(59) WP_042846365.1 synonyms: tet59 -> tet59,tetA(D) dfrA29 WP_045899678.1 pubmed_reference: -> 20027306 vanY-D WP_049898469.1 pubmed_reference: -> 17724150 tet(M) WP_050232631.1 pubmed_reference: -> 16304164 aacA34 WP_052285801.1 subclass: AMINOGLYCOSIDE -> KANAMYCIN/TOBRAMYCIN bla2 WP_063839880.1 pubmed_reference: -> 15561870 aac(6')-Ib WP_063840280.1 pubmed_reference: -> 26604259 aadA11 WP_063840415.1 pubmed_reference: -> 17298366 aadA21 WP_063840436.1 pubmed_reference: -> 17283193 aadA4 WP_063840444.1 pubmed_reference: -> 12726770 aadA7 WP_063840456.1 pubmed_reference: -> 18476779 aadA9 WP_063840458.1 pubmed_reference: -> 17298366 aph(6)-Id WP_063842184.1 pubmed_reference: -> 18676889 arr WP_063842214.1 pubmed_reference: -> 19686278 catA16 WP_063843221.1 pubmed_reference: -> 16304164 catB3 WP_063843227.1 pubmed_reference: -> 18550679 dfrA1 WP_063844292.1 pubmed_reference: -> 15837385 dfrA12 WP_063844298.1 pubmed_reference: -> 16451182,16785718 dfrA15 WP_063844362.1 pubmed_reference: -> 16966396 dfrA17 WP_063844367.1 pubmed_reference: -> 18550679 dfrA33 WP_063844371.1 pubmed_reference: -> 20027306 floR WP_063845118.1 pubmed_reference: -> 16966396 mef(A) WP_063853591.1 pubmed_reference: -> 15563518 mef(A) WP_063853689.1 pubmed_reference: -> 16304164 mef(A) WP_063853698.1 pubmed_reference: -> 19258262 mef(A) WP_063853705.1 pubmed_reference: -> 19258262 oleD WP_063854495.1 pubmed_reference: 17376874 -> 15984838,17376874 sul1 WP_063855066.1 pubmed_reference: -> 16339607 tet(A) WP_063855983.1 pubmed_reference: -> 18676889 tet(M) WP_063856390.1 pubmed_reference: -> 15519474 tet(M) WP_063856391.1 pubmed_reference: -> 15519474 tet(M) WP_063856392.1 pubmed_reference: -> 15519474 tet(M) WP_063856398.1 pubmed_reference: -> 16565156 tet(M) WP_063856399.1 pubmed_reference: -> 16565156 tet(O) WP_063856404.1 pubmed_reference: -> 15563518 tet(O) WP_063856405.1 pubmed_reference: -> 15910229 tet(T) WP_063856413.1 pubmed_reference: -> 15910229 tet(W) WP_063856417.1 pubmed_reference: -> 16870752 tet(W) WP_063856418.1 pubmed_reference: -> 16870752 tet(O/W/32/O) WP_063856419.1 pubmed_reference: -> 17967912 tet(O/W/32/O) WP_063856420.1 pubmed_reference: -> 17178791 tet(O/W/O) WP_063856421.1 pubmed_reference: -> 17178791 tet(W) WP_063856424.1 pubmed_reference: -> 18614524 tet(W) WP_063856425.1 pubmed_reference: -> 18614524 vanA-Pa WP_063856526.1 pubmed_reference: -> 15561881 vanA-Pt WP_063856531.1 pubmed_reference: -> 15561881 vanB WP_063856593.1 pubmed_reference: 15616278 -> 15616278,15855482 vanB WP_063856625.1 pubmed_reference: -> 19273676 vanG WP_063856696.1 pubmed_reference: -> 16723588 vanH-Ac1 WP_063856698.1 pubmed_reference: -> 16476725 vanH-B WP_063856701.1 pubmed_reference: -> 19273676 vanR-B WP_063856723.1 pubmed_reference: 15616278 -> 15616278,15855482 vanR-D WP_063856727.1 pubmed_reference: -> 19258279 vanS-B WP_063856739.1 pubmed_reference: -> 15731199 vanW-B WP_063856763.1 pubmed_reference: -> 15731199 vanW-B WP_063856765.1 pubmed_reference: -> 19273676 vanX-Ac1 WP_063856768.1 pubmed_reference: -> 16476725 vanX-B WP_063856772.1 pubmed_reference: -> 15731199 vanX-D WP_063856776.1 pubmed_reference: -> 19258279 vanXY WP_063856783.1 pubmed_reference: -> 16723588 vanY-D WP_063856881.1 pubmed_reference: -> 17000737 arr WP_063857694.1 pubmed_reference: -> 19686278 aadA1 WP_071846252.1 pubmed_reference: -> 17913715 aadA1 WP_071846253.1 pubmed_reference: -> 17913715 aacA34 WP_071846255.1 subclass: AMINOGLYCOSIDE -> KANAMYCIN/TOBRAMYCIN aadA2 WP_071846274.1 pubmed_reference: -> 16339607 ant(2'')-Ia WP_071846303.1 pubmed_reference: -> 15837385 aadA1 WP_071846304.1 pubmed_reference: -> 15837385 aadA1 WP_071846339.1 pubmed_reference: -> 16911867 aadA1 WP_071846340.1 pubmed_reference: -> 16911867 aadA1 WP_071846342.1 pubmed_reference: -> 18476779 aadA1 WP_071846343.1 pubmed_reference: -> 18476779 aadA9 WP_071846344.1 pubmed_reference: -> 17298366 aadA2 WP_071846345.1 pubmed_reference: -> 17298366 aadA3 WP_071846346.1 pubmed_reference: -> 18710912 aadA3 WP_071846364.1 pubmed_reference: -> 18710912 dfrA1 WP_071846366.1 pubmed_reference: -> 17913715 aadA5 WP_071846379.1 pubmed_reference: -> 18550679 aadA5 WP_071846381.1 pubmed_reference: -> 18550679 tet(W/32/O) WP_204313011.1 pubmed_reference: -> 17967912 1 WP_003703066.1 allele: -> 1 aacA56 WP_045890872.1 pubmed_reference: -> 37537271 subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN blaACT-13 WP_063857735.1 pubmed_reference: -> 24267783 blaACT-20 WP_063857769.1 pubmed_reference: -> 24916079 blaACT-21 WP_063857770.1 pubmed_reference: -> 24916079 blaACT-73 WP_152315464.1 pubmed_reference: -> 25022578 blaADC-112 WP_136512054.1 pubmed_reference: -> 18591275 blaADC-113 WP_136512055.1 pubmed_reference: -> 18591275 blaADC-116 WP_017816757.1 pubmed_reference: -> 23723398 blaAMZ-1 WP_280147732.1 pubmed_reference: -> 37808287 blaCMY-100 WP_063859613.1 pubmed_reference: -> 24916079 blaCMY-101 WP_016155498.1 pubmed_reference: -> 24916079 blaCMY-102 WP_063859625.1 pubmed_reference: -> 24916079 blaCMY-103 WP_063859632.1 pubmed_reference: -> 24916079 blaCMY-89 WP_063859891.1 pubmed_reference: -> 24267783 blaCMY-90 WP_063859909.1 pubmed_reference: -> 24267783 blaCTX-M-138 WP_070064534.1 pubmed_reference: -> 24916079 blaEAM-1 WP_122630825.1 pubmed_reference: -> 22850693 blaECM-1 WP_122630824.1 pubmed_reference: -> 22850693 blaEFM-1 WP_122630822.1 pubmed_reference: -> 22850693 blaELM-1 WP_081853183.1 pubmed_reference: -> 22850693 blaEVM-1 WP_122630823.1 pubmed_reference: -> 22850693 blaKPC-154 WP_309367897.1 product_name: class A beta-lactamase KPC-154 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-154 pubmed_reference: -> 37877547 blaLEN-38 WP_136086342.1 pubmed_reference: -> 30817987 blaLEN-39 WP_136026639.1 pubmed_reference: -> 30817987 blaLEN-40 WP_136049560.1 pubmed_reference: -> 30817987 blaLEN-41 WP_100675621.1 pubmed_reference: -> 30817987 blaLEN-42 WP_061154665.1 pubmed_reference: -> 30817987 blaLEN-43 WP_074385924.1 pubmed_reference: -> 30817987 blaOKP-B-16 WP_064183695.1 pubmed_reference: -> 30817987 blaOKP-B-24 WP_156404657.1 pubmed_reference: -> 30817987 blaOKP-C-1 WP_136034107.1 pubmed_reference: -> 30817987 blaOKP-D-1 WP_080897395.1 pubmed_reference: -> 30817987 blaOXA-151 WP_048806429.1 pubmed_reference: -> 26349828 blaOXA-152 WP_063861050.1 pubmed_reference: -> 26349828 blaOXA-153 WP_048627819.1 pubmed_reference: -> 26349828 blaOXA-154 WP_063861062.1 pubmed_reference: -> 26349828 blaOXA-155 WP_063861067.1 pubmed_reference: -> 26349828 blaOXA-156 WP_052266736.1 pubmed_reference: -> 26349828 blaOXA-157 WP_058375744.1 pubmed_reference: -> 26349828 blaOXA-158 WP_063861081.1 pubmed_reference: -> 26349828 blaOXA-159 WP_063861087.1 pubmed_reference: -> 26349828 blaOXA-309 WP_063862593.1 pubmed_reference: -> 24267783 blaOXA-336 WP_063862707.1 pubmed_reference: -> 25616788 blaOXA-338 WP_063862710.1 pubmed_reference: -> 25616788 blaOXA-339 WP_063862711.1 pubmed_reference: -> 25616788 blaOXA-340 WP_057053864.1 pubmed_reference: -> 25616788 blaOXA-341 WP_063862712.1 pubmed_reference: -> 25616788 blaOXA-342 WP_063862713.1 pubmed_reference: -> 25616788 blaOXA-343 WP_063862714.1 pubmed_reference: -> 25616788 blaOXA-344 WP_063862715.1 pubmed_reference: -> 25616788 blaOXA-345 WP_063862716.1 pubmed_reference: -> 25616788 blaOXA-346 WP_063862717.1 pubmed_reference: -> 25616788 blaOXA-374 WP_032051604.1 pubmed_reference: -> 28925528 blaOXA-375 WP_063862741.1 pubmed_reference: -> 28925528 blaOXA-376 WP_063862742.1 pubmed_reference: -> 28925528 blaOXA-377 WP_063862743.1 pubmed_reference: -> 28925528 blaOXA-378 WP_032058439.1 pubmed_reference: -> 28925528 blaOXA-379 WP_063862744.1 pubmed_reference: -> 28925528 blaOXA-380 WP_063862745.1 pubmed_reference: -> 28925528 blaOXA-381 WP_063862746.1 pubmed_reference: -> 28925528 blaOXA-382 WP_063862747.1 pubmed_reference: -> 28925528 blaOXA-383 WP_024438993.1 pubmed_reference: -> 28925528 blaOXA-384 WP_063862748.1 pubmed_reference: -> 28925528 blaOXA-385 WP_063862749.1 pubmed_reference: -> 28925528 blaOXA-386 WP_063862750.1 pubmed_reference: -> 28925528 blaOXA-388 WP_063862752.1 pubmed_reference: -> 28925528 blaOXA-389 WP_063862753.1 pubmed_reference: -> 28925528 blaOXA-390 WP_063862754.1 pubmed_reference: -> 28925528 blaOXA-406 WP_063862763.1 pubmed_reference: -> 25616788 blaOXA-408 WP_063862764.1 pubmed_reference: -> 25616788 blaOXA-409 WP_063862765.1 pubmed_reference: -> 25616788 blaOXA-411 WP_063862766.1 pubmed_reference: -> 25616788 blaOXA-412 WP_063862767.1 pubmed_reference: -> 25616788 blaOXA-413 WP_063862768.1 pubmed_reference: -> 25616788 blaOXA-414 WP_063862769.1 pubmed_reference: -> 25616788 blaOXA-429 WP_063862915.1 pubmed_reference: -> 28925528 blaOXA-430 WP_063862927.1 pubmed_reference: -> 28925528 blaOXA-431 WP_063862945.1 pubmed_reference: -> 28925528 blaOXA-432 WP_063864076.1 pubmed_reference: -> 28925528 blaOXA-433 WP_063864077.1 pubmed_reference: -> 28925528 blaOXA-472 WP_063864095.1 pubmed_reference: -> 26315325 blaOXA-473 WP_063864096.1 pubmed_reference: -> 26315325 blaOXA-474 WP_063864097.1 pubmed_reference: -> 26315325 blaOXA-475 WP_063864098.1 pubmed_reference: -> 26315325 blaOXA-476 WP_063864099.1 pubmed_reference: -> 26315325 blaOXA-477 WP_063864100.1 pubmed_reference: -> 26315325 blaOXA-478 WP_063864101.1 pubmed_reference: -> 26315325 blaOXA-479 WP_063864102.1 pubmed_reference: -> 26315325 blaOXA-485 WP_033954903.1 pubmed_reference: -> 26604259 blaOXA-494 WP_003118452.1 pubmed_reference: -> 26604259 blaOXA-543 WP_058132644.1 pubmed_reference: 28658322 -> 26604259,28658322 blaOXA-544 WP_071537493.1 pubmed_reference: 28658322 -> 26604259,28658322 blaPDC-30 WP_003110141.1 pubmed_reference: 36918743 -> 25022578,36918743 blaPDC-31 WP_016562272.1 pubmed_reference: -> 25022578 blaPDC-34 WP_003137570.1 pubmed_reference: -> 25022578 blaPDC-36 WP_023100808.1 pubmed_reference: -> 25022578 blaPDC-37 WP_023092413.1 pubmed_reference: -> 25022578 blaPDC-38 WP_022580963.1 pubmed_reference: -> 25022578 blaPDC-39 WP_023091031.1 pubmed_reference: -> 25022578 blaPDC-40 WP_063864581.1 pubmed_reference: -> 25022578 blaPDC-42 WP_063864582.1 pubmed_reference: -> 25022578 blaPDC-46 WP_043083525.1 pubmed_reference: -> 25022578 blaPDC-58 WP_063864583.1 pubmed_reference: -> 25022578 blaPDC-60 WP_043089496.1 pubmed_reference: -> 25022578 blaPDC-64 WP_043104614.1 pubmed_reference: -> 25022578 blaPDC-71 WP_031630420.1 pubmed_reference: -> 25022578 blaPEN-A18 WP_105835300.1 pubmed_reference: -> 35512733 blaPEN-A32 WP_105762373.1 pubmed_reference: -> 35512733 blaPEN-A34 WP_105856053.1 pubmed_reference: -> 35512733 blaPEN-A37 WP_088929369.1 pubmed_reference: -> 35512733 blaPEN-A4 WP_105781374.1 pubmed_reference: -> 19075063 blaPEN-B1 WP_109342732.1 pubmed_reference: -> 19075063 rmtD1 WP_019726361.1 pubmed_reference: -> 17158944,18391044 Hierarchy nodes added core AMR AMR aac(2')-I aac(2') aminoglycoside 2'-N-acetyltransferase aac(2')-I(A267) aac(2')-I(A267) aminoglycoside N-acetyltransferase AAC(2')-I(A267) aac(2')-II aac(2')-II aminoglycoside N-acetyltransferase AAC(2')-II aac(3)-C1264 aac(3)-C1264 aminoglycoside N-acetyltransferase AAC(3)-C1264 aac(3)-C322 aac(3)-C322 aminoglycoside N-acetyltransferase AAC(3)-C322 aac(6')-D292 aac(6')-D292 aminoglycoside 6'-N-acetyltransferase AAC(6')-D292 aac(6')-D42 aac(6')-D42 aminoglycoside 6'-N-acetyltransferase AAC(6')-D42 aac(6')-F309 aac(6')-F309 aminoglycoside 6'-N-acetyltransferase AAC(6')-F309 aac(6')-F72 aac(6')-F72 aminoglycoside 6'-N-acetyltransferase AAC(6')-F72 aac(6')_E aac(6') NF043067.1 aminoglycoside 6'-N-acetyltransferase aac(6')_E111 aac(6')-E111 aminoglycoside 6'-N-acetyltransferase AAC(6')-E111 aac(6')_E449 aac(6')-E449 aminoglycoside 6'-N-acetyltransferase AAC(6')-E449 aac(6')_E526 aac(6')-E526 aminoglycoside 6'-N-acetyltransferase AAC(6')-E526 aac(6')_E550 aac(6')-E550 aminoglycoside 6'-N-acetyltransferase AAC(6')-E550 aac(6')_E553 aac(6')-E553 aminoglycoside 6'-N-acetyltransferase AAC(6')-E553 aac(6')_E606 aac(6')-E606 aminoglycoside 6'-N-acetyltransferase AAC(6')-E606 aac(6')_E64 aac(6')-E64 aminoglycoside 6'-N-acetyltransferase AAC(6')-E64 aac(6')_E657 aac(6')-E657 aminoglycoside 6'-N-acetyltransferase AAC(6')-E657 aac(6')_E963 aac(6')-E963 aminoglycoside 6'-N-acetyltransferase AAC(6')-E963 aph(2'')-G141 aph(2'')-G141 aminoglycoside O-phosphotransferase APH(2')-G141 aph(3')-H48 aph(3')-H48 aminoglycoside O-phosphotransferase APH(3')-H48 aph(3')-H510 aph(3')-H510 aminoglycoside O-phosphotransferase APH(3')-H510 aph(3')-I(H957) aph(3')-I(H957) aminoglycoside O-phosphotransferase APH(3')-I(H957) blaCDA blaCDA CDA family class C beta-lactamase blaYOC blaYOC YOC family class C beta-lactamase non-reported AMR AMR aac(6')_Salmo aac(6') NF000140.3 AAC(6')-Iy/Iaa family aminoglycoside 6'-N-acetyltransferase plus AMR AMR cplR cplR NF043038.1 ABC-F type ribosomal protection protein CplR plus VIRULENCE VIRULENCE stxA2m stxA2m Shiga toxin Stx2m subunit A stxA2n stxA2n Shiga toxin Stx2n subunit A stxB2l stxB2l Shiga toxin Stx2l subunit B Hierarchy nodes removed core AMR AMR tetA(D) tetA(D) Tet(D)-related tetracycline efflux MFS transporter Changed Hierarchy Nodes aac(2') aminoglycoside 2'-N-acetyltransferase node_id: aac(2') -> aac(2')-I aac(2')-IIa kasugamycin N-acetyltransferase AAC(2')-IIa parent_node_id: aac(2') -> aac(2')-II aac(2')-IIb kasugamycin N-acetyltransferase AAC(2')-IIb parent_node_id: aac(2') -> aac(2')-II aac(2')-Ia aminoglycoside N-acetyltransferase AAC(2')-Ia parent_node_id: aac(2') -> aac(2')-I aac(2')-Ib aminoglycoside N-acetyltransferase AAC(2')-Ib parent_node_id: aac(2') -> aac(2')-I aac(2')-Ic aminoglycoside N-acetyltransferase AAC(2')-Ic parent_node_id: aac(2') -> aac(2')-I aac(2')-Id aminoglycoside N-acetyltransferase AAC(2')-Id parent_node_id: aac(2') -> aac(2')-I aac(2')-Ie aminoglycoside N-acetyltransferase AAC(2')-Ie parent_node_id: aac(2') -> aac(2')-I aac(6')-I AAC(6')-I family aminoglycoside 6'-N-acetyltransferase parent_node_id: aac(6') -> aac(6')_E aac(6')-III tobramycin N-acetyltransferase AAC(6')-III parent_node_id: aac(6') -> aac(6')_E aac(6')-Iag aminoglycoside 6'-N-acetyltransferase AAC(6')-Iag parent_node_id: aac(6') -> aac(6')_E aac(6')-Ian aminoglycoside N-acetyltransferase AAC(6')-Ian parent_node_id: aac(6')-I -> aac(6') aac(6')-Ie_fam AAC(6')-Ie family aminoglycoside N-acetyltransferase parent_node_id: aac(6')-I -> aac(6') aac(6')-Im aminoglycoside N-acetyltransferase AAC(6')-Im parent_node_id: aac(6')-I -> aac(6') aac(6')_Serra aminoglycoside 6'-N-acetyltransferase parent_node_id: aac(6') -> aac(6')_E aac(6')_Steno aminoglycoside 6'-N-acetyltransferase parent_node_id: aac(6') -> aac(6')_E aac(6')_Yersi aminoglycoside 6'-N-acetyltransferase parent_node_id: aac(6') -> aac(6')_E aacA10 AAC(6')-I family aminoglycoside 6'-N-acetyltransferase parent_node_id: aac(6')-I -> aac(6') aacA34 aminoglycoside 6'-N-acetyltransferase AacA34 subclass: AMINOGLYCOSIDE -> KANAMYCIN/TOBRAMYCIN aph(3')-IX aminoglycoside O-phosphotransferase APH(3')-IX name: APH(3') family aminoglycoside O-phosphotransferase -> aminoglycoside O-phosphotransferase APH(3')-IX ariR biofilm/acid-resistance regulator AriR synonyms: -> ymgB blaOXA-PR class D beta-lactamase display_parent: 0 -> 1 dfrB trimethoprim-resistant dihydrofolate reductase DfrB hmm_acc: NF000331.1 -> NF000331.2 lpfA-O113 long polar fimbria major subunit LpfA-O113 symbol: lpfA -> lpfA-O113 pbp penicillin-binding protein display_parent: 0 -> 1 stxA1e Shiga toxin Stx1e subunit A class: -> STX1 subclass: -> STX1E stxA2_acd Shiga toxin Stx2 subunit A, a/c/d subtype class: -> STX2 subclass: -> STX2 stxA2_eilk Shiga toxin Stx2 subunit A, e/i/l/k subtype class: -> STX2 subclass: -> STX2 stxA2o Shiga toxin Stx2o subunit A class: -> STX2 subclass: -> STX2O stxB1e Shiga toxin Stx1e subunit B class: -> STX1 subclass: -> STX1E stxB2m Shiga toxin Stx2m subunit B class: -> STX2 subclass: -> STX2M stxB2n Shiga toxin Stx2n subunit B class: -> STX2 subclass: -> STX2N stxB2o Shiga toxin Stx2o subunit B class: -> STX2 subclass: -> STX2O tet(30) tetracycline efflux MFS transporter Tet(30) hmm_acc: -> NF045486.1 tet(59) tetracycline efflux MFS transporter Tet(59) synonyms: tet59 -> tet59,tetA(D) tet(62) tetracycline efflux MFS transporter Tet(62) hmm_acc: -> NF045488.1 ---------------------------------------------------------------------- Changes included in 2023-09-26.1 ---------------------------------------------------------------------- Overview: - 62 new core alleles or new protein sequences - Several new point mutations including blaTEM-1 promoter mutations. The blaTEM promoter mutations are identified with the gene symbol blaTEMp and use the coordinate system defined by Sutcliffe (PMID 358200) - Refined point mutation phenotypes for point mutations already in the database - Five new HMMs and 6 new hierarchy nodes - Refined subclasses for cfr genes - The symbol for the eatA_T450I point mutation is changed to eat(A)_T450I to match the protein gene symbol and help differentiate the eat(A) ABC-F type ribosomal protection protein from eatA, the unrelated serine protease autotransporter toxin. We didn't create the nomenclature we just report it. NOTE: The format of ReferenceGeneHierarchy.txt has changed; two new columns were added. See https://github.com/ncbi/amr/wiki/AMRFinderPlus-database#referencegenehierarchytxt for information on the format of that file. Summary: Total proteins: 7890 Core proteins: 6778 Plus proteins: 1111 AMR proteins: 6819 STRESS proteins: 253 VIRULENCE proteins: 818 PubMed references: 3866 Point mutations: 1235 Point mutation reference sequences: 216 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae, Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 723 Updates since release 2023-08-08.2: Proteins added: 65 Core proteins added: 62 Plus proteins added: 2 AMR proteins added: 63 STRESS proteins added: 1 Alleles added: 51 PubMed references added: 49 PubMed references removed: 1 Point mutations added: 19 Proteins removed: 0 Core proteins removed: 0 Plus proteins removed: 0 Point mutations removed 0 Reference Gene Catalog entries changed: 21 Hierarchy nodes added: 6 Hierarchy nodes removed: 5 Hierarchy nodes changed: 9 Added proteins core AMR AMR fos NG_231529.1 WP_000777201.1 fosfomycin resistance glutathione transferase FosLL blaOCH NG_231520.1 WP_029376317.1 OCH family extended-spectrum class C beta-lactamase erm(55) NG_231525.1 WP_046361760.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55) erm(56) NG_231528.1 WP_129546809.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(56) blaOCH NG_231519.1 WP_311033290.1 OCH family extended-spectrum class C beta-lactamase blaOCH NG_231521.1 WP_311033291.1 OCH family extended-spectrum class C beta-lactamase blaOCH NG_231522.1 WP_311033292.1 OCH family extended-spectrum class C beta-lactamase blaOCH NG_231523.1 WP_311033293.1 OCH family extended-spectrum class C beta-lactamase blaOCH NG_231524.1 WP_311033294.1 OCH family extended-spectrum class C beta-lactamase erm(55) NG_231526.1 WP_311033295.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55) erm(55) NG_231527.1 WP_311033296.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55) blaACT-120 NG_231530.1 WP_311033297.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-120 blaACT-121 NG_231531.1 WP_311033298.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-121 blaACT-122 NG_231532.1 WP_311033299.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-122 blaACT-123 NG_231533.1 WP_311033300.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-123 blaACT-124 NG_231534.1 WP_311033301.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-124 blaADC-338 NG_231535.1 WP_279984225.1 extended-spectrum class C beta-lactamase ADC-338 blaADC-339 NG_231536.1 WP_311033302.1 extended-spectrum class C beta-lactamase ADC-339 blaADC-340 NG_231537.1 WP_311033303.1 extended-spectrum class C beta-lactamase ADC-340 blaADC-341 NG_231538.1 WP_311033304.1 extended-spectrum class C beta-lactamase ADC-341 blaADC-342 NG_231539.1 WP_225519091.1 extended-spectrum class C beta-lactamase ADC-342 blaADC-343 NG_231540.1 WP_032035727.1 extended-spectrum class C beta-lactamase ADC-343 blaCMH-13 NG_231541.1 WP_248048813.1 class C beta-lactamase CMH-13 blaCTX-M-70 NG_231542.1 WP_063860071.1 extended-spectrum class A beta-lactamase CTX-M-70 blaDHA-31 NG_231543.1 WP_311033305.1 class C beta-lactamase DHA-31 blaIMP-102 NG_231544.1 WP_311033306.1 subclass B1 metallo-beta-lactamase IMP-102 blaKPC-154 NG_231545.1 WP_309367897.1 class A beta-lactamase KPC-154 blaKPC-170 NG_231546.1 WP_311033307.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-170 blaKPC-185 NG_231547.1 WP_311033308.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-185 blaKPC-186 NG_231548.1 WP_311033309.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-186 blaKPC-187 NG_231549.1 WP_311033310.1 inhibitor-resistant class A beta-lactamase KPC-187 blaKPC-189 NG_231550.1 WP_311033311.1 extended-spectrum class A beta-lactamase KPC-189 blaKPC-190 NG_231551.1 WP_311033312.1 inhibitor-resistant class A beta-lactamase KPC-190 blaKPC-191 NG_231552.1 WP_311033313.1 inhibitor-resistant class A beta-lactamase KPC-191 blaKPC-192 NG_231553.1 WP_311033314.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-192 blaNDM-61 NG_231554.1 WP_311033315.1 subclass B1 metallo-beta-lactamase NDM-61 blaOXA-1206 NG_231555.1 WP_284495840.1 class D beta-lactamase OXA-1206 blaOXA-1214 NG_231556.1 WP_311033316.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1214 blaOXA-1215 NG_231557.1 WP_275573817.1 OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-1215 blaOXA-1216 NG_231558.1 WP_311033317.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1216 blaOXA-1217 NG_231559.1 WP_311033318.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1217 blaOXA-1218 NG_231560.1 WP_311033319.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1218 blaOXA-1219 NG_231561.1 WP_311033320.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1219 blaOXA-1220 NG_231562.1 WP_311033321.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1220 blaOXA-1222 NG_231563.1 WP_032034809.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1222 blaPDC-564 NG_231564.1 WP_311033322.1 class C beta-lactamase PDC-564 blaPDC-565 NG_231565.1 WP_262961480.1 class C beta-lactamase PDC-565 blaPDC-566 NG_231566.1 WP_311033323.1 class C beta-lactamase PDC-566 blaPDC-567 NG_231567.1 WP_311033324.1 class C beta-lactamase PDC-567 blaPDC-568 NG_231568.1 WP_311033325.1 class C beta-lactamase PDC-568 blaPDC-569 NG_231569.1 WP_311033326.1 class C beta-lactamase PDC-569 blaPDC-570 NG_231570.1 WP_311033327.1 class C beta-lactamase PDC-570 blaPDC-571 NG_231571.1 WP_311033328.1 class C beta-lactamase PDC-571 blaPDC-572 NG_231572.1 WP_114012592.1 class C beta-lactamase PDC-572 blaPDC-573 NG_231573.1 WP_311033329.1 class C beta-lactamase PDC-573 blaPDC-574 NG_231574.1 WP_311033330.1 class C beta-lactamase PDC-574 blaPDC-575 NG_231575.1 WP_311033331.1 class C beta-lactamase PDC-575 blaPDC-576 NG_231576.1 WP_209038818.1 class C beta-lactamase PDC-576 mcr-1.36 NG_231577.1 WP_311033332.1 phosphoethanolamine--lipid A transferase MCR-1.36 mcr-4.8 NG_231578.1 WP_311033333.1 phosphoethanolamine--lipid A transferase MCR-4.8 mcr-5.5 NG_231579.1 WP_311033334.1 phosphoethanolamine--lipid A transferase MCR-5.5 qnrB84 NG_231580.1 WP_284957973.1 quinolone resistance pentapeptide repeat protein QnrB84 plus AMR AMR vanR-Cd NZ_CP011847.1 WP_003436401.1 vancomycin resistance response regulator transcription factor VanR-G-Cd plus STRESS HEAT clpL CP001603.1 ADB69780.1 ATP-dependent protease ClpL Added point mutations core AMR POINT baeR_S104N CEFIDEROCOL Acinetobacter_baumannii baeS_D89V CEFIDEROCOL Acinetobacter_baumannii blaTEMp_C141G AMOXICILLIN-CLAVULANIC ACID/PIPERACILLIN-TAZOBACTAM/TICARCILLIN-CLAVULANIC ACID Escherichia blaTEMp_C32T AMOXICILLIN-CLAVULANIC ACID/PIPERACILLIN-TAZOBACTAM/TICARCILLIN-CLAVULANIC ACID Escherichia blaTEMp_G162T AMOXICILLIN-CLAVULANIC ACID/PIPERACILLIN-TAZOBACTAM/TICARCILLIN-CLAVULANIC ACID Escherichia dacB_I356A CEPHALOSPORIN Pseudomonas_aeruginosa eat(A)_T450I PLEUROMUTILIN Enterococcus_faecium ftsI_T526S SULBACTAM-DURLOBACTAM Acinetobacter_baumannii mexR_Q94STOP CEPHALOSPORIN Pseudomonas_aeruginosa rpoB_D492Y RIFAXIMIN Clostridioides_difficile rpoB_G510R RIFAXIMIN Clostridioides_difficile rpoB_H502R RIFAXIMIN Clostridioides_difficile rpoB_L584F RIFAXIMIN Clostridioides_difficile rpoB_Q489L RIFAXIMIN Clostridioides_difficile rpoB_R505L RIFAXIMIN Clostridioides_difficile rpoB_S488Y RIFAXIMIN Clostridioides_difficile rpoB_S507L RIFAXIMIN Clostridioides_difficile rpsJ_Y58D TIGECYCLINE Staphylococcus_aureus vanR-Cd_T115A VANCOMYCIN Clostridioides_difficile Changed reference gene catalog records cfr WP_001010505.1 class: -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN pubmed_reference: -> 16801432 subclass: CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMULIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN B/TIAMULIN/VIRGINIAMYCIN cfr(B) WP_002349981.1 class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN pubmed_reference: -> 26248384 subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/RETAPAMULIN/STREPTOGRAMIN B/VIRGINIAMYCIN cfr(B) WP_002405682.1 class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/RETAPAMULIN/STREPTOGRAMIN B/VIRGINIAMYCIN cfr WP_011987126.1 class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN A/TIAMULIN cfr WP_032491462.1 class: -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMULIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN B/TIAMULIN/VIRGINIAMYCIN cfr(E) WP_105119688.1 class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN pubmed_reference: -> 31685464 subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> LINCOSAMIDE/LINEZOLID/THIAMPHENICOL/TIAMULIN/VIRGINIAMYCIN cfr(D) WP_105459893.1 class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN pubmed_reference: -> 32277823 subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/STREPTOGRAMIN B/TEDIZOLID/TIAMULIN cfr(B) WP_111690897.1 class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/RETAPAMULIN/STREPTOGRAMIN B/VIRGINIAMYCIN cfr(C) WP_111690898.1 class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN pubmed_reference: -> 28186558 subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN/TIAMULIN blaAFM-1 WP_069953510.1 pubmed_reference: -> 34545931,34826621 blaAFM-2 WP_204376224.1 pubmed_reference: -> 34826621 blaAFM-3 WP_211862582.1 pubmed_reference: -> 34826621 blaKPC-31 WP_073668892.1 pubmed_reference: 34339281 -> 33915286,34339281,36964710 subclass: CEPHALOSPORIN -> CEFIDEROCOL/CEPHALOSPORIN blaKPC-62 WP_204376229.1 pubmed_reference: 33775814,36964710 -> 33775814,33915286,36964710 subclass: CEPHALOSPORIN -> CEFIDEROCOL/CEPHALOSPORIN blaOXA-1203 WP_281441144.1 curated_refseq_start: Yes -> No genbank_protein_accession: -> WMF72384.1 blaOXY_G-34A NZ_CP026715.1 product_name: blaOXY promoter region -> blaOXY promoter region blaOXY_G-38T NZ_CP026715.1 product_name: blaOXY promoter region -> blaOXY promoter region blaOXY_T-58A NZ_CP026715.1 product_name: blaOXY promoter region -> blaOXY promoter region blaOXY_T-67C NZ_CP026715.1 product_name: blaOXY promoter region -> blaOXY promoter region ftsI_A515V WP_000227936.1 pubmed_reference: 29547094 -> 29547094,31988095,35127562,35618210 subclass: CARBAPENEM -> CARBAPENEM/SULBACTAM-DURLOBACTAM ftsI_N337NYRIN WP_000642196.1 pubmed_reference: 25634992,32988825 -> 25634992,32988825,37610183 subclass: AZTREONAM -> AZTREONAM/CEFIDEROCOL Hierarchy nodes added core AMR AMR blaOXA-1206_fam blaOXA OXA-1206 family class D beta-lactamase blaOXA-837_fam blaOXA NF042983.1 OXA-837 family class D beta-lactamase erm(55) erm(55) NF042938.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55) erm(56) erm(56) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(56) fosLL fos NF033405.1 fosfomycin resistance glutathione transferase FosLL plus STRESS HEAT clpL clpL ATP-dependent protease ClpL Hierarchy nodes removed non-reported AMR AMR-SUSCEPTIBLE AMR-SUSCEPTIBLE Families implicated in adaptive resistance by mutation pbp pbp penicillin-binding protein pbp1a pbp1a penicillin-binding protein pbp2b pbp2b penicillin-binding protein pbp2x pbp2x penicillin-binding protein Changed Hierarchy Nodes SMR_efflux_emrE multidrug efflux SMR transporter EmrE hmm_acc: NF000336.1 -> NF042984.1 cfr 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr subclass: PHENICOL/CLINDAMYCIN/LINEZOLID/TIAMULIN/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN B/TIAMULIN/VIRGINIAMYCIN cfr(B) 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(B) class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/RETAPAMULIN/STREPTOGRAMIN B/VIRGINIAMYCIN cfr(C) 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(C) class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN/TIAMULIN cfr(D) 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(D) class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/STREPTOGRAMIN B/TEDIZOLID/TIAMULIN cfr(E) 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E) class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> LINCOSAMIDE/LINEZOLID/THIAMPHENICOL/TIAMULIN/VIRGINIAMYCIN cfr-Cb Cfr family 23S rRNA (adenine(2503)-C(8))-methyltransferase class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN A/TIAMULIN eat(A) ABC-F type ribosomal protection protein Eat(A) name: ABC-F type ribosomal protection-like protein Eat(A) -> ABC-F type ribosomal protection protein Eat(A) erm(46) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(46) hmm_acc: -> NF042988.1 ---------------------------------------------------------------------- Changes included in 2023-08-08.2 ---------------------------------------------------------------------- Overview: - A major review and revision of macrolide / lincosamide / pleuromutilin / streptogramin class and subclass designations - Additional phenotype curation of class/subclass and product name for some blaOXA genes and other beta-lactamases - As usual, new named alleles for those genes whose allele nomenclature NCBI curates Summary: Total proteins: 7827 Core proteins: 6716 Plus proteins: 1110 AMR proteins: 6757 STRESS proteins: 252 VIRULENCE proteins: 818 PubMed references: 3818 Point mutations: 1217 Point mutation reference sequences: 211 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae, Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 719 Updates since release 2023-07-13.2: Proteins added: 25 Core proteins added: 25 Plus proteins added: 0 AMR proteins added: 25 Alleles added: 24 PubMed references added: 295 Point mutations added: 53 Reference Gene Catalog entries changed: 494 Hierarchy nodes changed: 84 Added proteins core AMR AMR blaL1 NG_228664.1 WP_304486996.1 L1 family subclass B3 metallo-beta-lactamase blaADC-336 NG_228665.1 WP_057690145.1 extended-spectrum class C beta-lactamase ADC-336 blaADC-337 NG_228666.1 WP_304486997.1 extended-spectrum class C beta-lactamase ADC-337 blaBIC-2 NG_228667.1 WP_304486998.1 carbapenem-hydrolyzing class A beta-lactamase BIC-2 blaCTX-M-266 NG_228668.1 WP_304486999.1 extended-spectrum class A beta-lactamase CTX-M-266 blaCTX-M-267 NG_228669.1 WP_072643680.1 extended-spectrum class A beta-lactamase CTX-M-267 blaKPC-158 NG_228670.1 WP_304487000.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-158 blaKPC-181 NG_228671.1 WP_163591930.1 carbapenem-hydrolyzing class A beta-lactamase KPC-181 blaKPC-182 NG_228672.1 WP_304487001.1 carbapenem-hydrolyzing class A beta-lactamase KPC-182 blaKPC-183 NG_228673.1 WP_304487002.1 carbapenem-hydrolyzing class A beta-lactamase KPC-183 blaKPC-184 NG_228674.1 WP_304487003.1 carbapenem-hydrolyzing class A beta-lactamase KPC-184 blaOXA-1211 NG_228675.1 WP_304487004.1 OXA-48 family class D beta-lactamase OXA-1211 blaOXA-1212 NG_228676.1 WP_304487005.1 OXA-48 family class D beta-lactamase OXA-1212 blaOXA-1213 NG_228677.1 WP_304487006.1 OXA-48 family class D beta-lactamase OXA-1213 blaPDC-554 NG_228678.1 WP_304487007.1 class C beta-lactamase PDC-554 blaPDC-555 NG_228679.1 WP_304487008.1 class C beta-lactamase PDC-555 blaPDC-556 NG_228680.1 WP_304487009.1 class C beta-lactamase PDC-556 blaPDC-557 NG_228681.1 WP_304487010.1 class C beta-lactamase PDC-557 blaPDC-558 NG_228682.1 WP_304487011.1 class C beta-lactamase PDC-558 blaPDC-559 NG_228683.1 WP_304487012.1 class C beta-lactamase PDC-559 blaPDC-560 NG_228684.1 WP_304487013.1 class C beta-lactamase PDC-560 blaPDC-561 NG_228685.1 WP_304487014.1 class C beta-lactamase PDC-561 blaPDC-562 NG_228686.1 WP_304487015.1 class C beta-lactamase PDC-562 blaPDC-563 NG_228687.1 WP_304487016.1 class C beta-lactamase PDC-563 blaSHV-232 NG_228688.1 WP_087834333.1 class A beta-lactamase SHV-232 Added point mutations core AMR POINT dfrB_A135T TRIMETHOPRIM Staphylococcus_aureus dfrB_L25I TRIMETHOPRIM Staphylococcus_aureus folP_A184V SULFONAMIDE Staphylococcus_aureus folP_E208K SULFONAMIDE Staphylococcus_aureus folP_E258EKE SULFONAMIDE Staphylococcus_aureus folP_F17L SULFONAMIDE Staphylococcus_aureus folP_S18L SULFONAMIDE Staphylococcus_aureus folP_T51M SULFONAMIDE Staphylococcus_aureus nfsA_E75STOP NITROFURANTOIN Escherichia nfsA_G126R NITROFURANTOIN Escherichia nfsA_G154E NITROFURANTOIN Escherichia nfsA_H11Y NITROFURANTOIN Escherichia nfsA_Q113STOP NITROFURANTOIN Escherichia nfsA_Q67STOP NITROFURANTOIN Escherichia nfsA_W159STOP NITROFURANTOIN Escherichia nfsB_F84S NITROFURANTOIN Escherichia nfsB_G192D NITROFURANTOIN Escherichia nfsB_G192S NITROFURANTOIN Escherichia nfsB_W94STOP NITROFURANTOIN Escherichia ompC_Q171STOP CARBAPENEM Escherichia ompC_Q82STOP CARBAPENEM Escherichia ompF_L15STOP CARBAPENEM Escherichia ompF_Q88STOP CARBAPENEM Escherichia ompK36_E87STOP CARBAPENEM Klebsiella_pneumoniae ompK36_L307STOP CARBAPENEM Klebsiella_pneumoniae ompK36_Q313STOP CARBAPENEM Klebsiella_pneumoniae ompK36_Q66STOP CARBAPENEM Klebsiella_pneumoniae ompK36_Q70STOP CARBAPENEM Klebsiella_pneumoniae parR_M59I COLISTIN Pseudomonas_aeruginosa phoQ_D433STOP COLISTIN Pseudomonas_aeruginosa phoQ_I421STOP COLISTIN Pseudomonas_aeruginosa phoQ_LG364del COLISTIN Pseudomonas_aeruginosa phoQ_N104I COLISTIN Pseudomonas_aeruginosa phoQ_V152STOP COLISTIN Pseudomonas_aeruginosa pmrA_E8D COLISTIN Acinetobacter_baumannii pmrA_M12I COLISTIN Acinetobacter_baumannii pmrB_A227V COLISTIN Acinetobacter_baumannii pmrB_A248T COLISTIN Pseudomonas_aeruginosa pmrB_G315D COLISTIN Acinetobacter_baumannii pmrB_H340R COLISTIN Pseudomonas_aeruginosa pmrB_I164F COLISTIN Acinetobacter_baumannii pmrB_P170L COLISTIN Acinetobacter_baumannii pmrB_P233S COLISTIN Acinetobacter_baumannii pmrB_P233T COLISTIN Acinetobacter_baumannii pmrB_Q270P COLISTIN Acinetobacter_baumannii pmrB_R231L COLISTIN Acinetobacter_baumannii pmrB_R263L COLISTIN Acinetobacter_baumannii pmrB_S17R COLISTIN Acinetobacter_baumannii pmrB_S257N COLISTIN Pseudomonas_aeruginosa pmrB_T232I COLISTIN Acinetobacter_baumannii pmrB_T235I COLISTIN Acinetobacter_baumannii pmrB_T343A COLISTIN Pseudomonas_aeruginosa pmrB_V15I COLISTIN Pseudomonas_aeruginosa Changed reference gene catalog records mph(B) WP_000031017.1 pubmed_reference: -> 17302923 subclass: MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN msr(E) WP_000052512.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN pubmed_reference: 23114767 -> 23114767,29712846 subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN mph(E) WP_000155092.1 pubmed_reference: -> 15155196,17261525 subclass: MACROLIDE -> ERYTHROMYCIN mph(C) WP_000196697.1 pubmed_reference: -> 17302923 subclass: MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(A) WP_000219391.1 pubmed_reference: -> 8619599,17302923 subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mef(A) WP_000417517.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_000417519.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN msr(D) WP_000420313.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN pubmed_reference: 11398110 -> 11398110,26531240 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B msr(D) WP_000420317.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 26531240 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B msr(A) WP_000438874.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B erm(A) WP_000810833.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN erm(C) WP_001003260.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(C) WP_001003263.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: 3087948 -> 3087948,6783733 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(C) WP_001003264.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN cfr WP_001010505.1 subclass: CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMUTILIN -> CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMULIN erm(B) WP_001038790.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 104975,8878614 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(B) WP_001038792.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 11230937 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(B) WP_001038795.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 7514148 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(A) WP_001072197.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE pubmed_reference: -> 3004956 subclass: MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN erm(A) WP_001072201.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN erm(B) WP_002292226.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B msr(C) WP_002314314.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(B) WP_002321849.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 23442208 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(T) WP_002345002.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 16189118 subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN msr(A) WP_002447408.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B erm(F) WP_002682030.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN erm(D) WP_003183781.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN vmlR WP_003234144.1 class: MACROLIDE/PLEUROMUTILIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/STREPTOGRAMIN/TIAMULIN -> LINCOMYCIN/TIAMULIN/VIRGINIAMYCIN M mphK WP_003246254.1 subclass: MACROLIDE -> TELITHROMYCIN/TYLOSIN aac(2')-Ib WP_003881640.1 subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN aac(2')-Ic WP_003899880.1 subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN erm(37) WP_003900446.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE pubmed_reference: -> 14693532,16801446 subclass: MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN mgt WP_003972830.1 subclass: MACROLIDE -> ERYTHROMYCIN/TYLOSIN erm(O) WP_003972831.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/PRISTINAMYCIN/TYLOSIN aac(2')-Ia WP_004918308.1 subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN erm(35) WP_006745469.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN erm(Q) WP_007286427.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN erm(C) WP_007410443.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 6938954 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(E) WP_009950391.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN erm(C) WP_010889933.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: 3084450,3091582 -> 3084450,3091582,6271735 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(K) WP_010896559.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 36511701 subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN aac(2')-Ie WP_010908954.1 subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN erm(B) WP_011018369.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(T) WP_011100845.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(X) WP_011116967.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN erm(T) WP_011117197.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(X) WP_011117480.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN erm(33) WP_011133550.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE pubmed_reference: 12384375 -> 11864966,12384375 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN erm(X) WP_011152925.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 14576111 subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN erm(C) WP_011276921.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(C) WP_011282421.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(C) WP_011382144.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN aac(2')-Id WP_011726942.1 subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN erm(B) WP_011861426.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B mef(A) WP_012102963.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN erm(C) WP_014158490.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(42) WP_014325825.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN mph(E) WP_014325835.1 pubmed_reference: -> 15155196,17261525 subclass: MACROLIDE -> ERYTHROMYCIN mph(G) WP_014386803.1 pubmed_reference: -> 25765542 subclass: MACROLIDE -> ERYTHROMYCIN mef(C) WP_014386804.1 subclass: MACROLIDE -> ERYTHROMYCIN erm(G) WP_014387027.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN mef(A) WP_014636304.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN tva(B) WP_014936356.1 subclass: PLEUROMUTILIN/STREPTOGRAMIN -> TIAMULIN ere(A) WP_015059985.1 pubmed_reference: -> 33741980 erm(36) WP_015345217.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN ere(D) WP_015345560.1 pubmed_reference: -> 26107936,33741980 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mphH WP_015776248.1 pubmed_reference: -> 29317655 subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TYLOSIN mef(A) WP_018374806.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN erm(49) WP_019728092.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE pubmed_reference: 23882264 -> 23882264,29500262 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN mph(F) WP_021263608.1 pubmed_reference: -> 17101677 subclass: MACROLIDE -> ERYTHROMYCIN ere(A) WP_021566672.1 subclass: MACROLIDE -> ERYTHROMYCIN mphN WP_024127776.1 pubmed_reference: -> 24362420 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_024127829.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN erm(D) WP_025811090.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN oleI WP_030778152.1 subclass: MACROLIDE -> OLEANDOMYCIN erm(54) WP_031885508.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE pubmed_reference: -> 35639577 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN ere(A) WP_032084014.1 subclass: MACROLIDE -> ERYTHROMYCIN erm(X) WP_032488331.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 2110657 subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN ere(B) WP_032488343.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN erm(F) WP_032488512.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN erm(C) WP_032489009.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(C) WP_032489010.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(C) WP_032489011.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(C) WP_032489016.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(B) WP_032489723.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B ere(A) WP_032490532.1 subclass: MACROLIDE -> ERYTHROMYCIN cfr WP_032491462.1 subclass: CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMUTILIN -> CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMULIN mef(B) WP_032492336.1 pubmed_reference: -> 19131424 subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN erm(C) WP_032492416.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(40) WP_036428783.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN erm(39) WP_038563636.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN erm(44)v WP_041079981.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE pubmed_reference: -> 27799208 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN erm(B) WP_041152457.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(N) WP_050364506.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 30023575 subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(42) WP_052259183.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN srm(B) WP_053138477.1 subclass: MACROLIDE -> SPIRAMYCIN erm(O) WP_053138973.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 10517588 subclass: MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/PRISTINAMYCIN/TYLOSIN mgt WP_053138975.1 subclass: MACROLIDE -> ERYTHROMYCIN/TYLOSIN erm(30) WP_055641627.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 9770448 subclass: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN mef(A) WP_058621816.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN erm(Z) WP_063796790.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN ere(A) WP_063844484.1 subclass: MACROLIDE -> ERYTHROMYCIN ere(A) WP_063844485.1 subclass: MACROLIDE -> ERYTHROMYCIN ere(B) WP_063844486.1 pubmed_reference: -> 27786586 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN erm(31) WP_063844492.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 9770448 subclass: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN erm(34) WP_063844504.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN erm(38) WP_063844518.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE pubmed_reference: 16127056 -> 14506008,16127056 subclass: MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN erm(43) WP_063844520.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN erm(44) WP_063844521.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: 27799208 -> 25092709,27799208 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN erm(45) WP_063844522.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN erm(B) WP_063844601.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 7486927 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(B) WP_063844614.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(B) WP_063844619.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: 2832378 -> 2832378,3541783 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(C) WP_063844768.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(D) WP_063844769.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN erm(E) WP_063844770.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN erm(F) WP_063844771.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN erm(F) WP_063844773.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN erm(G) WP_063844787.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(G) WP_063844791.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(H) WP_063844794.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/TYLOSIN/VERNAMYCIN B erm(R) WP_063844815.1 subclass: MACROLIDE -> ERYTHROMYCIN erm(S) WP_063844819.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/OSTREOGRYCIN/TYLOSIN erm(T) WP_063844825.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(B) WP_063844850.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 11600385 subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(U) WP_063844854.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 8577249 subclass: MACROLIDE -> LINCOMYCIN/MACROLIDE/STREPTOGRAMIN erm(U) WP_063844861.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> LINCOMYCIN/MACROLIDE/STREPTOGRAMIN erm(V) WP_063844868.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/TYLOSIN/VERNAMYCIN B erm(W) WP_063844871.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(X) WP_063844879.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN erm(X) WP_063844889.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN erm(X) WP_063844894.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN erm(X) WP_063844922.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN erm(Y) WP_063844932.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: 9809423 -> 9809423,11751136 subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B mef(A) WP_063853554.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853563.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853574.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853591.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853602.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853625.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853632.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853638.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853648.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853682.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853689.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853698.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853705.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(A) WP_063853713.1 subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mgt WP_063853740.1 subclass: MACROLIDE -> ERYTHROMYCIN/TYLOSIN mph(A) WP_063853854.1 subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(A) WP_063853866.1 subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(C) WP_063853881.1 pubmed_reference: 9809423 -> 9809423,17302923 subclass: MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(C) WP_063853892.1 pubmed_reference: -> 17302923 subclass: MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(C) WP_063854131.1 pubmed_reference: 17005735 -> 17005735,17302923 subclass: MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(C) WP_063854137.1 pubmed_reference: 17005735 -> 17005735,17302923 subclass: MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(C) WP_063854150.1 pubmed_reference: 17005735 -> 17005735,17302923 subclass: MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN msr(A) WP_063854312.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B msr(A) WP_063854317.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B msr(A) WP_063854341.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B msr(C) WP_063854349.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN myrA WP_063854489.1 subclass: MACROLIDE -> TYLOSIN ole(B) WP_063854494.1 subclass: MACROLIDE -> OLEANDOMYCIN oleD WP_063854495.1 pubmed_reference: -> 17376874 subclass: MACROLIDE -> ERYTHROMYCIN/OLEANDOMYCIN/TYLOSIN tlr(C) WP_063856491.1 subclass: MACROLIDE -> TYLOSIN mphJ WP_087349244.1 pubmed_reference: -> 29259290 erm(46) WP_087587931.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: 25779586 -> 25779586,26377866 subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/VIRGINIAMYCIN erm(47) WP_087587932.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN erm(48) WP_087587948.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/PRISTINAMYCIN msr(G) WP_101035417.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 33118027 subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/PRISTINAMYCIN mef(F) WP_101035418.1 pubmed_reference: -> 33118027 subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN erm(51) WP_131386768.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN pubmed_reference: -> 32291839 subclass: MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/VIRGINIAMYCIN msrH WP_138070341.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/PRISTINAMYCIN tva(A) WP_151874537.1 subclass: PLEUROMUTILIN/STREPTOGRAMIN -> TIAMULIN msrF WP_164941513.1 class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/PRISTINAMYCIN erm(50) WP_176453837.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE pubmed_reference: -> 31844016 subclass: MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN estT WP_185148407.1 pubmed_reference: -> 36791107 subclass: MACROLIDE -> TYLOSIN mef(F) WP_188020219.1 subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN 23S_C658T NZ_CP019870.1 class: MACROLIDE -> LINCOSAMIDE/MACROLIDE blaAIM-1 WP_063857820.1 pubmed_reference: 22985886 -> 22985886,37255469 blaBEL-1 WP_063857830.1 pubmed_reference: 16127048 -> 16127048,37255469 blaBEL-2 WP_063857831.1 pubmed_reference: 19884378 -> 19884378,37255469 blaCMY-2 WP_000976514.1 product_name: class C beta-lactamase CMY-2 -> extended-spectrum class C beta-lactamase CMY-2 pubmed_reference: 8787910 -> 37255469,8787910 blaCMY-42 WP_039023136.1 pubmed_reference: 21388298,27799202 -> 21388298,27799202,37255469 blaCTX-M-14 WP_001617865.1 pubmed_reference: 11850241 -> 11850241,37255469 blaCTX-M-15 WP_000239590.1 pubmed_reference: 11470367 -> 11470367,37255469 blaCTX-M-3 WP_011091028.1 pubmed_reference: 9559791 -> 37255469,9559791 blaCTX-M-33 WP_032490682.1 pubmed_reference: 17234386 -> 17234386,37255469 blaCVI-1 WP_164461288.1 pubmed_reference: -> 37513808 blaDHA-1 WP_004236386.1 product_name: class C beta-lactamase DHA-1 -> extended-spectrum class C beta-lactamase DHA-1 pubmed_reference: 9736562 -> 37255469,9736562 blaDIM-1 WP_063860203.1 pubmed_reference: 20308383 -> 20308383,37255469 blaGES-1 WP_013250881.1 pubmed_reference: 10681329 -> 10681329,37255469 blaGES-2 WP_045912044.1 pubmed_reference: 11502535 -> 11502535,37255469 blaGES-5 WP_012658785.1 pubmed_reference: 15135524,19738007 -> 15135524,19738007,37255469 blaGES-6 WP_032490973.1 pubmed_reference: 15135524,19738007 -> 15135524,19738007,37255469 blaGIM-1 WP_015588753.1 pubmed_reference: 15561840 -> 15561840,37255469 blaIMI-1 WP_053073497.1 pubmed_reference: 8878585 -> 37255469,8878585 blaIMP-1 WP_003159548.1 pubmed_reference: 8141584 -> 37255469,8141584 blaKPC-180 WP_290468355.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-180 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-180 blaKPC-2 WP_004199234.1 pubmed_reference: 12615876 -> 12615876,37255469 blaKPC-3 WP_004152396.1 pubmed_reference: 15561858,19015357 -> 15561858,19015357,37255469 blaKPC-41 WP_148044419.1 pubmed_reference: 31527032 -> 31527032,37255469 blaNDM-1 WP_004201164.1 pubmed_reference: 19770275 -> 19770275,37255469 blaNDM-5 WP_023408309.1 pubmed_reference: 21930874 -> 21930874,37255469 blaNDM-7 WP_032495622.1 pubmed_reference: 23557929 -> 23557929,37255469 blaNDM-9 WP_032495672.1 pubmed_reference: 24913967,36796395,37394537 -> 24913967,36796395,37255469,37394537 blaNMC-A WP_050737109.1 pubmed_reference: 8052644 -> 8052644,37255469 blaOXA-1 WP_001334766.1 pubmed_reference: 2823258 -> 2823258,37255469 blaOXA-1013 WP_219860726.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1047 WP_213384363.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1048 WP_240067728.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1058 WP_242934079.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1059 WP_242934080.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1060 WP_242934081.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1061 WP_242934082.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1062 WP_242934083.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1063 WP_242934084.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1064 WP_242934085.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1065 WP_242934086.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1066 WP_242934087.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1067 WP_242934088.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1068 WP_242934089.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1069 WP_242934090.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1070 WP_242934091.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1071 WP_242934092.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1072 WP_242934093.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1073 WP_242934094.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1074 WP_242934095.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1075 WP_242934096.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1076 WP_215763651.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1077 WP_242934097.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1078 WP_242934098.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1079 WP_242934099.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1080 WP_242934100.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1092 WP_242934106.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1093 WP_242934107.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1094 WP_242934108.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1096 WP_242934110.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1097 WP_242934111.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1098 WP_242934112.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1109 WP_279240791.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1117 WP_249828065.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1118 WP_249828066.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1121 WP_256875611.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1122 WP_256875612.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1123 WP_256875613.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-18 WP_063861237.1 pubmed_reference: 9333046 -> 9333046,37255469 blaOXA-181 WP_015060052.1 pubmed_reference: 21768505 -> 21768505,37255469 blaOXA-23 WP_001046004.1 pubmed_reference: 10602749 -> 10602749,37255469 blaOXA-427 WP_096807440.1 pubmed_reference: 34427311 -> 34427311,37255469 blaOXA-48 WP_015059991.1 pubmed_reference: 14693513 -> 14693513,37255469 blaOXA-58 WP_002002480.1 pubmed_reference: 15616297 -> 15616297,37255469 blaOXA-680 WP_122630864.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-682 WP_122630884.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-683 WP_122630885.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-684 WP_122630886.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-685 WP_122630887.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-686 WP_122630888.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-687 WP_122630889.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-688 WP_122630890.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-689 WP_122630891.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-690 WP_122630892.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-691 WP_122630893.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-692 WP_122630894.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-693 WP_122630895.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-694 WP_122630896.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-695 WP_122630897.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-696 WP_122630898.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-697 WP_122630899.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-698 WP_122630900.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-699 WP_122630901.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-700 WP_122630902.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-701 WP_122630903.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-702 WP_122630904.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-703 WP_122630905.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-704 WP_122630906.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-705 WP_122630907.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-706 WP_122630908.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-707 WP_122630909.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-708 WP_122630916.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-709 WP_122630917.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-710 WP_122630918.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-711 WP_122630919.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-712 WP_122630920.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-713 WP_122630921.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-714 WP_122630922.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-715 WP_016685888.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-716 WP_031998610.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-717 WP_032018141.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-718 WP_122630910.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-719 WP_122630911.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-720 WP_122630912.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-721 WP_122630913.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-722 WP_122630914.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-723 WP_122630915.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-733 WP_122630844.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-734 WP_122630853.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-735 WP_122630854.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-738 WP_128268238.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-739 WP_114225343.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-740 WP_128268239.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-741 WP_128268240.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-742 WP_128268241.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-743 WP_128268242.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-744 WP_128268243.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-745 WP_128268244.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-746 WP_128268245.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-747 WP_128268246.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-748 WP_128268247.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-749 WP_128268248.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-750 WP_128268249.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-751 WP_128268250.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-752 WP_128268251.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-753 WP_128268252.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-754 WP_128268253.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-755 WP_128268254.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-756 WP_128268255.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-757 WP_128268256.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-758 WP_128268257.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-759 WP_128268258.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-760 WP_128268259.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-761 WP_128268260.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-762 WP_128268261.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-763 WP_128268262.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-764 WP_128268263.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-765 WP_128268264.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-766 WP_128268265.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-767 WP_128268266.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-768 WP_128268267.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-769 WP_128268268.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-770 WP_128268269.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-771 WP_128268270.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-772 WP_128268271.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-773 WP_128268272.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-774 WP_128268273.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-775 WP_128268274.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-776 WP_128268275.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-781 WP_128268276.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-782 WP_128268277.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-797 WP_136512088.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-798 WP_136512089.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-799 WP_136512090.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-800 WP_136512091.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-828 WP_140423321.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-829 WP_140423322.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-831 WP_140423323.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-834 WP_125052736.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-852 WP_152315469.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-853 WP_114252036.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-854 WP_114158997.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-855 WP_032061328.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-856 WP_001021774.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-857 WP_152315470.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-858 WP_152315471.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-859 WP_152315472.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-860 WP_152315473.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-861 WP_152315474.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-862 WP_152315475.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-863 WP_152315476.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-864 WP_152315477.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-865 WP_152315478.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-866 WP_152315479.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-867 WP_152315480.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-868 WP_152315481.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-869 WP_152315482.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-870 WP_152315483.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-871 WP_152315484.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-872 WP_152315485.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-873 WP_152315486.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-874 WP_152315487.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-875 WP_152315488.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-876 WP_152315489.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-877 WP_152315490.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-878 WP_152315491.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-879 WP_152315492.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-880 WP_152315493.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-881 WP_152315494.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-882 WP_152315495.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-883 WP_152315496.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-884 WP_152315497.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-885 WP_152315498.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-886 WP_152315499.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-887 WP_152315500.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-888 WP_152315501.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-889 WP_152315502.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-890 WP_152315503.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-891 WP_152315504.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-892 WP_152315505.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-909 WP_162278338.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-910 WP_162280230.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-916 WP_171476790.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-927 WP_047480628.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-938 WP_086263559.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-939 WP_086261538.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-940 WP_086442870.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-954 WP_213994599.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-955 WP_213994600.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-970 WP_231869597.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-971 WP_231869598.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-972 WP_231869599.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-973 WP_231869600.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-974 WP_231869601.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-975 WP_231869602.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-976 WP_001022757.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-977 WP_231869603.1 subclass: BETA-LACTAM -> CARBAPENEM blaPDC-30 WP_003110141.1 product_name: class C beta-lactamase PDC-30 -> cephalosporin-hydrolyzing class C beta-lactamase PDC-30 pubmed_reference: -> 36918743 blaPDC-519 WP_256875627.1 product_name: class C beta-lactamase PDC-519 -> inhibitor-resistant cephalosporin-hydrolyzing class C beta-lactamase PDC-519 pubmed_reference: -> 36918743 blaPER-1 WP_001100753.1 pubmed_reference: 8141562 -> 37255469,8141562 blaPER-2 WP_032491907.1 pubmed_reference: 17438050,8851581 -> 17438050,37255469,8851581 blaPER-6 WP_063864595.1 product_name: extended-spectrum class A beta-lactamase PER-6 -> inhibitor-resistant extended-spectrum class A beta-lactamase PER-6 pubmed_reference: 20145085 -> 20145085,37255469 blaPER-7 WP_032495440.1 product_name: extended-spectrum class A beta-lactamase PER-7 -> inhibitor-resistant extended-spectrum class A beta-lactamase PER-7 pubmed_reference: 21383087 -> 21383087,37255469 blaSHV-1 WP_001620095.1 pubmed_reference: 10582889 -> 10582889,37255469 blaSHV-12 WP_002904004.1 pubmed_reference: 9145849 -> 37255469,9145849 blaSHV-2A WP_032488413.1 pubmed_reference: 10223953,1741919 -> 10223953,1741919,37255469 blaSME-1 WP_063864724.1 pubmed_reference: 8092824 -> 37255469,8092824 blaSPM-1 WP_063864747.1 pubmed_reference: -> 37255469 blaTEM-1 WP_000027057.1 pubmed_reference: 5326330 -> 37255469,5326330 blaTEM-3 WP_032488414.1 pubmed_reference: 3316146 -> 3316146,37255469 blaVEB-1 WP_000706731.1 pubmed_reference: 10049269 -> 10049269,37255469 blaVIM-1 WP_013263789.1 pubmed_reference: 10390207,18804966 -> 10390207,18804966,37255469 blaVIM-2 WP_003108247.1 pubmed_reference: 10722487,18804966 -> 10722487,18804966,37255469 dfrB_F99Y WP_000175752.1 pubmed_reference: -> 36935372 dfrB_H150R WP_000175752.1 pubmed_reference: -> 36935372 dfrB_L41F WP_000175752.1 pubmed_reference: -> 36935372 gyrA_A196E WP_001281243.1 pubmed_reference: -> 14506034 gyrA_A51V WP_001281243.1 pubmed_reference: -> 11451702 gyrA_A67S WP_001281243.1 pubmed_reference: -> 2168148 gyrA_A84P WP_001281243.1 pubmed_reference: -> 2168148 gyrA_A84V WP_001281243.1 pubmed_reference: -> 7840592 gyrA_D82G WP_001281243.1 pubmed_reference: -> 8980760 gyrA_D87G WP_001281243.1 pubmed_reference: 9756773 -> 8849244,8891148,14506034,9988045,29091182,9756773,8849244,8891148,14506034,9988045 gyrA_D87H WP_001281243.1 pubmed_reference: -> 29091182,8891148,14506034,12654733,11310803 gyrA_D87N WP_001281243.1 pubmed_reference: -> 7840592,8891148,14506034,11699598 gyrA_D87V WP_001281243.1 pubmed_reference: -> 1850972 gyrA_D87Y WP_001281243.1 pubmed_reference: -> 8849244,7840592,8891148,11310803,14506034 gyrA_G81C WP_001281243.1 pubmed_reference: -> 2168148 gyrA_G81D WP_001281243.1 pubmed_reference: -> 8392306,8392306 subclass: CIPROFLOXACIN -> QUINOLONE gyrA_Q106H WP_001281243.1 pubmed_reference: -> 2168148 gyrA_Q106R WP_001281243.1 pubmed_reference: -> 1850970 gyrA_S83A WP_001281243.1 pubmed_reference: -> 10590273,12654733,11699598 gyrA_S83L WP_001281243.1 pubmed_reference: -> 8849244,8891148,14506034,11699598 gyrA_S83V WP_001281243.1 pubmed_reference: -> 10590273,12654733 gyrA_S83W WP_001281243.1 pubmed_reference: -> 2168148,8849244,2548439 gyrB_D426N WP_000072067.1 pubmed_reference: -> 1656869 gyrB_K447E WP_000072067.1 pubmed_reference: -> 1656869,7840592 gyrB_S464F WP_000072047.1 pubmed_reference: -> 14718091,12760900 subclass: CIPROFLOXACIN -> QUINOLONE gyrB_S464T WP_000072047.1 pubmed_reference: -> 7590165 subclass: CIPROFLOXACIN -> QUINOLONE gyrB_S464Y WP_000072047.1 pubmed_reference: -> 7590165,12705680 subclass: CIPROFLOXACIN -> QUINOLONE nfsA_G131D WP_089631889.1 pubmed_reference: -> 34860151 parC_A108V WP_001281881.1 pubmed_reference: -> 11302820 parC_A56T WP_001281881.1 pubmed_reference: -> 12654733 parC_E84G WP_001281881.1 pubmed_reference: -> 8849244,11310803,12654733,14506034,11699598,14706091 parC_E84K WP_001281881.1 pubmed_reference: -> 8851598,8849244,11310803,12654733,14706091 parC_E84V WP_001281881.1 pubmed_reference: -> 8834907,12654733,14706091 parC_G78D WP_001281881.1 pubmed_reference: -> 8849244,8851598 parC_G78K WP_001281881.1 pubmed_reference: -> 14510643 parC_S57T WP_001281881.1 pubmed_reference: -> 12654733,14510643 parC_S80I WP_001281881.1 pubmed_reference: -> 8849244,8891148,14506034,11699598,14506034,14706091 parC_S80R WP_001281881.1 pubmed_reference: -> 8851598,8849244,8891148,12654733,14506034 parC_W106G WP_001281910.1 pubmed_reference: -> 27630841 parE_E460D WP_033554192.1 pubmed_reference: -> 14510643 parE_I444F WP_033554192.1 pubmed_reference: -> 14506034 parE_I464F WP_033554192.1 pubmed_reference: -> 14510643 parE_I529L WP_033554192.1 pubmed_reference: -> 14506034 parE_L416F WP_033554192.1 pubmed_reference: -> 14510643 parE_L445H WP_033554192.1 pubmed_reference: -> 8980775 parE_S458T WP_033554192.1 pubmed_reference: -> 14506034 pmrA_G15R WP_000697899.1 pubmed_reference: -> 25505462 pmrA_G53E WP_000697899.1 pubmed_reference: -> 25505462 pmrA_G53R WP_000697899.1 pubmed_reference: -> 25505462 pmrA_R81C WP_000697899.1 pubmed_reference: -> 25505462 pmrA_R81H WP_000697899.1 pubmed_reference: -> 25505462 pmrB_A226T WP_000559382.1 pubmed_reference: 34609499 -> 34609499,21497062 pmrB_E121A WP_001212189.1 pubmed_reference: -> 25505462 pmrB_E166K WP_001212189.1 pubmed_reference: -> 25505462 pmrB_G188D WP_003112923.1 pubmed_reference: 22106224 -> 22106224,22106224 pmrB_G206R WP_001212189.1 pubmed_reference: -> 25505462 pmrB_G206W WP_001212189.1 pubmed_reference: -> 25505462 pmrB_L14F WP_001212189.1 pubmed_reference: -> 25505462 pmrB_L14S WP_001212189.1 pubmed_reference: -> 25505462 pmrB_L22P WP_001212189.1 pubmed_reference: -> 25505462 pmrB_M186I WP_001212189.1 pubmed_reference: -> 25505462 pmrB_N130Y WP_001212189.1 pubmed_reference: -> 25505462 pmrB_P94Q WP_001212189.1 pubmed_reference: -> 25505462 pmrB_R14del WP_004179093.1 pubmed_reference: -> 23997018 pmrB_R155P WP_001212189.1 pubmed_reference: -> 25505462 pmrB_S124P WP_001212189.1 pubmed_reference: -> 25505462 pmrB_S208N WP_004179093.1 pubmed_reference: -> 23997018 pmrB_S29R WP_001212189.1 pubmed_reference: -> 25505462 pmrB_S305R WP_001212189.1 pubmed_reference: -> 25505462 pmrB_T147P WP_001212189.1 pubmed_reference: -> 25505462 pmrB_T156M WP_001212189.1 pubmed_reference: -> 25505462 pmrB_T156P WP_001212189.1 pubmed_reference: -> 25505462 pmrB_T92A WP_001212189.1 pubmed_reference: -> 25505462 pmrB_V161G WP_001212189.1 pubmed_reference: -> 25505462 Changed Hierarchy Nodes aac(2')-Ia aminoglycoside N-acetyltransferase AAC(2')-Ia subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN aac(2')-Ib aminoglycoside N-acetyltransferase AAC(2')-Ib subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN aac(2')-Ic aminoglycoside N-acetyltransferase AAC(2')-Ic subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN aac(2')-Id aminoglycoside N-acetyltransferase AAC(2')-Id subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN aac(2')-Ie aminoglycoside N-acetyltransferase AAC(2')-Ie subclass: GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN blaOXA-23_fam OXA-23 family carbapenem-hydrolyzing class D beta-lactamase subclass: BETA-LACTAM -> CARBAPENEM cfr 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr class: PHENICOL/LINCOSAMIDE/OXAZOLIDINONES/PLEUROMUTILIN/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN subclass: PHENICOL/CLINDAMYCIN/LINEZOLID/TIAMUTILIN/STREPTOGRAMIN -> PHENICOL/CLINDAMYCIN/LINEZOLID/TIAMULIN/STREPTOGRAMIN ere(A) EreA family erythromycin esterase subclass: MACROLIDE -> ERYTHROMYCIN ere(B) EreB family erythromycin esterase subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN ere(D) EreD family erythromycin esterase subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN erm(30) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(30) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN erm(31) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(31) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN erm(33) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(33) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN erm(34) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(34) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN erm(35) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(35) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN erm(36) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(36) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN erm(37) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN erm(38) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(38) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN erm(39) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(39) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN erm(40) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(40) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN erm(42) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(42) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN erm(43) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(43) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN erm(44) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(44) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN erm(44)v 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(44)v class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN erm(45) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(45) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN erm(46) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(46) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/VIRGINIAMYCIN erm(47) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(47) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN erm(48) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(48) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/PRISTINAMYCIN erm(49) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(49) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN erm(50) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN erm(51) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(51) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/VIRGINIAMYCIN erm(54) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(54) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN erm(A) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE subclass: MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN erm(B) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(C) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(C) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN erm(D) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(D) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN erm(E) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(E) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN erm(F) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(F) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN erm(G) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(G) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(H) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(H) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/TYLOSIN/VERNAMYCIN B erm(K) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(K) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(N) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(N) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(O) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(O) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/PRISTINAMYCIN/TYLOSIN erm(Q) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(Q) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN erm(R) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(R) subclass: MACROLIDE -> ERYTHROMYCIN erm(S) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(S) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/OSTREOGRYCIN/TYLOSIN erm(T) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(T) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(U) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(U) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> LINCOMYCIN/MACROLIDE/STREPTOGRAMIN erm(V) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(V) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/TYLOSIN/VERNAMYCIN B erm(W) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(W) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN erm(X) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(X) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN erm(Y) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(Y) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B erm(Z) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(Z) class: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN estT macrolide hydrolase EstT subclass: MACROLIDE -> TYLOSIN mef(A) macrolide efflux MFS transporter Mef(A) subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN mef(B) macrolide efflux MFS transporter Mef(B) subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN mef(C) macrolide efflux MFS transporter Mef(C) subclass: MACROLIDE -> ERYTHROMYCIN mef(F) macrolide efflux MFS transporter Mef(F) subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN mgt macrolide-inactivating glycosyltransferase subclass: MACROLIDE -> ERYTHROMYCIN/TYLOSIN mph(A) Mph(A) family macrolide 2'-phosphotransferase subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(B) Mph(B) family macrolide 2'-phosphotransferase subclass: MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(C) Mph(C) family macrolide 2'-phosphotransferase subclass: MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN mph(E) Mph(E) family macrolide 2'-phosphotransferase subclass: MACROLIDE -> ERYTHROMYCIN mph(F) Mph(F) family macrolide 2'-phosphotransferase subclass: MACROLIDE -> ERYTHROMYCIN mph(G) Mph(G) family macrolide 2'-phosphotransferase subclass: MACROLIDE -> ERYTHROMYCIN mphH macrolide 2'-phosphotransferase MphH subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TYLOSIN mphK macrolide 2'-phosphotransferase MphK subclass: MACROLIDE -> TELITHROMYCIN/TYLOSIN mphN macrolide 2'-phosphotransferase MphN subclass: MACROLIDE -> ERYTHROMYCIN msr(A) ABC-F type ribosomal protection protein Msr(A) class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B msr(C) ABC-F type ribosomal protection protein Msr(C) class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN msr(D) ABC-F type ribosomal protection protein Msr(D) class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B msr(E) ABC-F type ribosomal protection protein Msr(E) class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN msr(F) ABC-F type ribosomal protection protein Msr(F) class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/PRISTINAMYCIN msr(G) ABC-F type ribosomal protection protein Msr(G) class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/PRISTINAMYCIN msr(H) ABC-F type ribosomal protection protein Msr(H) class: MACROLIDE -> MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE -> ERYTHROMYCIN/PRISTINAMYCIN myrA 23S rRNA (guanine(748)-N(1))-methyltransferase MyrA subclass: MACROLIDE -> TYLOSIN ole(B) ABC-F type ribosomal protection protein Ole(B) subclass: MACROLIDE -> OLEANDOMYCIN oleD oleandomycin glycosyltransferase OleD subclass: MACROLIDE -> ERYTHROMYCIN/OLEANDOMYCIN/TYLOSIN oleI OleI family self-immunity macrolide glycosyltransferase subclass: MACROLIDE -> OLEANDOMYCIN srm(B) ABC-F type ribosomal protection protein Srm(B) subclass: MACROLIDE -> SPIRAMYCIN tlr(C) ABC-F type ribosomal protection protein Tlr(C) subclass: MACROLIDE -> TYLOSIN tva(A) ABC-F type ribosomal protection protein Tva(A) subclass: PLEUROMUTILIN/STREPTOGRAMIN -> TIAMULIN tva(B) ABC-F type ribosomal protection protein Tva(B) subclass: PLEUROMUTILIN/STREPTOGRAMIN -> TIAMULIN vmlR ABC-F type ribosomal protection protein VmlR class: MACROLIDE/PLEUROMUTILIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/STREPTOGRAMIN/TIAMULIN -> LINCOMYCIN/TIAMULIN/VIRGINIAMYCIN M ---------------------------------------------------------------------- Changes included in 2023-07-13.2 ---------------------------------------------------------------------- Overview: - Name and subclass changed for blaNDM-9 to highlight that, unlike other NDMs, NDM-9 is taniborbactam resistant - Changed symbol for AAC74250.1 to ariR to match protein name - Review and revision of van genes to standardize nomenclature led to changes symbol and name in a number of genes (particularly vanS) - Protein name changes toward standardizing the naming of some genes, particularly adhesins - Curation and addition of recently published stx variants led to new stx genes, HMMs, hierarchy nodes, and changes in names for some Stx protein sequences - Further curation of specific phenotypes based on the literature - Several efflux pumps were moved from AMR to BIOCIDE/STRESS to reflect their primary activity against benzenes - Some new beta-lacatamase families added - 13 new point mutations including baeS mutations for Enterobacter_asburiae and blaOXA promoter mutations for Acinetobacter_baumannii Summary: Total proteins: 7802 Core proteins: 6691 Plus proteins: 1110 AMR proteins: 6732 STRESS proteins: 252 VIRULENCE proteins: 818 PubMed references: 3516 Point mutations: 1164 Point mutation reference sequences: 206 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae, Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 719 Updates since release 2023-04-17.1: Proteins added: 65 Core proteins added: 44 Plus proteins added: 21 AMR proteins added: 46 STRESS proteins added: 8 VIRULENCE proteins added: 11 Alleles added: 39 PubMed references added: 88 Point mutations added: 13 Proteins removed: 2 Core proteins removed: 1 Plus proteins removed: 1 Reference Gene Catalog entries changed: 179 Hierarchy nodes added: 21 Hierarchy nodes changed: 69 Added proteins core AMR AMR dfrA44 NG_073446.2 WP_031380727.1 trimethoprim-resistant dihydrofolate reductase DfrA44 estT NG_203374.1 WP_185148407.1 macrolide hydrolase EstT tetB(60) NG_203376.1 WP_289811733.1 tetracycline efflux ABC transporter Tet(60) subunit B tetA(60) NG_203375.1 WP_289811734.1 tetracycline efflux ABC transporter Tet(60) subunit A dfrL NG_203373.1 WP_290468344.1 trimethoprim-resistant dihydrofolate reductase DfrL blaADC-334 NG_203377.1 WP_002052571.1 extended-spectrum class C beta-lactamase ADC-334 blaADC-335 NG_203378.1 WP_290468345.1 extended-spectrum class C beta-lactamase ADC-335 blaAMZ-1 NG_203379.1 WP_280147732.1 class C beta-lactamase AMZ-1 blaBIM-1 NG_203380.1 WP_099592735.1 subclass B1 metallo-beta-lactamase BIM-1 blaCHM-1 NG_203381.1 WP_202272142.1 subclass B1 metallo-beta-lactamase CHM-1 blaCMY-186 NG_203383.1 WP_281461078.1 class C beta-lactamase CMY-186 blaCTX-M-260 NG_157064.1 WP_279383147.1 extended-spectrum class A beta-lactamase CTX-M-260 blaCTX-M-261 NG_203384.1 WP_242935024.1 extended-spectrum class A beta-lactamase CTX-M-261 blaCTX-M-262 NG_203385.1 WP_290468346.1 extended-spectrum class A beta-lactamase CTX-M-262 blaCTX-M-263 NG_203386.1 WP_290468347.1 extended-spectrum class A beta-lactamase CTX-M-263 blaCTX-M-264 NG_203387.1 WP_290468348.1 extended-spectrum class A beta-lactamase CTX-M-264 blaCTX-M-265 NG_203388.1 WP_290468349.1 extended-spectrum class A beta-lactamase CTX-M-265 blaDHA-30 NG_203389.1 WP_283624015.1 class C beta-lactamase DHA-30 blaGES-59 NG_203390.1 WP_290468350.1 class A beta-lactamase GES-59 blaIMP-100 NG_203391.1 WP_285798245.1 subclass B1 metallo-beta-lactamase IMP-100 blaIND-17 NG_203392.1 WP_214824597.1 subclass B1 metallo-beta-lactamase IND-17 blaKPC-124 NG_203393.1 WP_290468351.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-124 blaKPC-129 NG_203394.1 WP_290468352.1 class A beta-lactamase KPC-129 blaKPC-178 NG_203395.1 WP_290468353.1 inhibitor-resistant class A beta-lactamase KPC-178 blaKPC-179 NG_203396.1 WP_290468354.1 class A beta-lactamase KPC-179 blaKPC-180 NG_203397.1 WP_290468355.1 carbapenem-hydrolyzing class A beta-lactamase KPC-180 blaNDM-56 NG_203399.1 WP_280940591.1 subclass B1 metallo-beta-lactamase NDM-56 blaNDM-57 NG_203400.1 WP_280146998.1 subclass B1 metallo-beta-lactamase NDM-57 blaNDM-58 NG_203401.1 WP_290468356.1 subclass B1 metallo-beta-lactamase NDM-58 blaNDM-60 NG_203402.1 WP_290468357.1 subclass B1 metallo-beta-lactamase NDM-60 blaOXA-1012 NG_203403.1 WP_252655163.1 OXA-48 family class D beta-lactamase OXA-1012 blaOXA-1200 NG_203404.1 WP_290468358.1 OXA-48 family class D beta-lactamase OXA-1200 blaOXA-1201 NG_203405.1 WP_290468359.1 OXA-48 family class D beta-lactamase OXA-1201 blaOXA-1202 NG_203406.1 WP_290468360.1 OXA-10 family class D beta-lactamase OXA-1202 blaOXA-1203 NG_203407.1 WP_281441144.1 OXA-10 family class D beta-lactamase OXA-1203 blaOXA-1205 NG_203408.1 WP_290468361.1 OXA-48 family class D beta-lactamase OXA-1205 blaOXA-1207 NG_203409.1 WP_290468362.1 OXA-48 family class D beta-lactamase OXA-1207 blaOXA-1208 NG_203410.1 WP_290468363.1 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-1208 blaPDC-553 NG_203412.1 WP_290468364.1 class C beta-lactamase PDC-553 blaPSZ-1 NG_203413.1 WP_290468365.1 class C beta-lactamase PSZ-1 blaTEM-251 NG_203416.1 WP_222898572.1 class A beta-lactamase TEM-251 blaVIM-84 NG_203417.1 WP_256823972.1 subclass B1 metallo-beta-lactamase VIM-84 blaVIM-85 NG_203418.1 WP_260890415.1 subclass B1 metallo-beta-lactamase VIM-85 mcr-1.35 NG_203419.1 WP_290468366.1 phosphoethanolamine--lipid A transferase MCR-1.35 plus AMR AMR narA MN590304.1 QHA94808.1 ionophore ABC transporter ATP-binding subunit NarA narB MN590304.1 QHA94809.1 ionophore ABC transporter permease subunit NarB plus STRESS METAL arsN2 CP000150.1 ABB05616.1 arsenic resistance N-acetyltransferase ArsN2 arsN2 CP000386.1 ABG05788.1 arsenic resistance N-acetyltransferase ArsN2 arsN2 CP000804.1 ABU58394.1 arsenic resistance N-acetyltransferase ArsN2 arsN1 CP009286.1 AIQ64103.1 arsinothricin resistance N-acetyltransferase ArsN1 family A arsN2 LDTF01000097.1 KTT96020.1 arsenic resistance N-acetyltransferase ArsN2 arsN1 LVVJ01000026.1 KYZ65872.1 arsinothricin resistance N-acetyltransferase ArsN1 family A arsN1 FORR01000002.1 SFI81893.1 arsinothricin resistance N-acetyltransferase ArsN1 family A arsN2 CP090098.1 UIK15784.1 arsenic resistance N-acetyltransferase ArsN2 plus VIRULENCE VIRULENCE stxA2k KC339670.2 AGB13719.2 Shiga toxin Stx2k subunit A stxB1e KF926684.1 AHJ80154.1 Shiga toxin Stx1e subunit B stxA1e KF926684.1 AHJ80155.1 Shiga toxin Stx1e subunit A peg-344 AP006726.1 BAH65947.1 DMT family inner membrane transporter PEG344 stxB2j RUOX02000009.1 EED0303793.1 Shiga toxin Stx2j subunit B stxA2o AARLAS010000016.1 EEV0948227.1 Shiga toxin Stx2o subunit A stxB2o AARLAS010000016.1 EEV0948228.1 Shiga toxin Stx2o subunit B stxB2k CP041435.1 QHR28666.1 Shiga toxin Stx2k subunit B stxA2k CP041435.1 QHR28667.1 Shiga toxin Stx2k subunit A stxB2n CP113092.1 WAK53219.1 Shiga toxin Stx2n subunit B stxB2m OQ054797.1 WGO76392.1 Shiga toxin Stx2m subunit B Added point mutations core AMR POINT baeS_T175P AZTREONAM/TEMOCILLIN/TICARCILLIN Enterobacter_cloacae baeS_T175P AZTREONAM/TEMOCILLIN/TICARCILLIN Enterobacter_asburiae blaOXA_A-14G CARBAPENEM Acinetobacter_baumannii blaOXA_G-42A CARBAPENEM Acinetobacter_baumannii rpoB_D471E RIFAMPIN Staphylococcus_aureus rpoB_D516G RIFAMPIN Escherichia rpoB_H526L RIFAMPIN Escherichia rpoB_L511Q RIFAMPIN Escherichia rpoB_N474L RIFAMPIN Staphylococcus_aureus rpoB_Q148L RIFAMPIN Escherichia rpoB_S583L RIFAMPIN Acinetobacter_baumannii rpoB_V1143D FIDAXOMICIN Clostridioides_difficile rpoB_V1143G FIDAXOMICIN Clostridioides_difficile Removed proteins core AMR AMR dfrA44 NG_073446.1 WP_204376220.1 trimethoprim-resistant dihydrofolate reductase DfrA44 plus VIRULENCE VIRULENCE stxB2d DQ059012.1 AAY63865.1 Shiga toxin Stx2d subunit B Changed reference gene catalog records cph AAA92037.1 pubmed_reference: -> 34994196 ttgB AAC38671.1 pubmed_reference: -> 14506010 subtype: AMR -> BIOCIDE type: AMR -> STRESS ariR AAC74250.1 gene_family: ymgB -> ariR srpB AAD12176.1 pubmed_reference: -> 9417051 subtype: AMR -> BIOCIDE type: AMR -> STRESS ttgI AAD12177.1 pubmed_reference: -> 11395460 subtype: AMR -> BIOCIDE type: AMR -> STRESS srpA AAD12178.1 pubmed_reference: -> 9417051 subtype: AMR -> BIOCIDE type: AMR -> STRESS tbtA AAD15663.1 pubmed_reference: -> 15019728 tbtB AAD15664.1 pubmed_reference: -> 15019728 tbtM AAD15665.1 pubmed_reference: -> 15019728 ttgA AAD39553.1 pubmed_reference: -> 14506010 subtype: AMR -> BIOCIDE type: AMR -> STRESS mtrA AAD44693.1 pubmed_reference: -> 23221802 farB AAD54074.1 pubmed_reference: -> 10447892 mdsB AAL19305.1 pubmed_reference: -> 24960027,26283336 mdsA AAL19306.1 pubmed_reference: -> 24960027,26283336 bepD AAN29240.1 pubmed_reference: -> 19201794 bepE AAN29241.1 pubmed_reference: -> 19201794 bepC AAN29871.1 pubmed_reference: -> 19201794 bepG AAN33534.1 pubmed_reference: -> 19201794 bepF AAN33535.1 pubmed_reference: -> 19201794 adeE AAN38824.2 pubmed_reference: -> 15388479,30311872 sdeB AAO18187.2 pubmed_reference: -> 15793131 ttgD AAO49780.1 pubmed_reference: -> 11251828 subtype: AMR -> BIOCIDE type: AMR -> STRESS emhC AAQ92182.1 pubmed_reference: -> 14563857 adeD AAU10477.1 pubmed_reference: -> 15388479 mepA AAU95768.1 class: EFFLUX -> TETRACYCLINE pubmed_reference: -> 15855508 subclass: EFFLUX -> TIGECYCLINE emhA AAY90617.2 pubmed_reference: -> 14563857 fdeC ABE05822.1 product_name: intimin-like adhesin FdeC -> inverse autotransporter adhesin FdeC emrD3 ABQ18953.1 pubmed_reference: -> 19876617 kdeA ABR76310.1 pubmed_reference: -> 17917272 mtrR ACF30254.1 pubmed_reference: -> 23221802 emhB ACO06752.1 pubmed_reference: -> 14563857 amvA ACQ82816.1 pubmed_reference: -> 20573661 ttgE ADI95409.1 pubmed_reference: -> 26363557 subtype: AMR -> BIOCIDE type: AMR -> STRESS ranA ADZ12699.1 class: -> EFFLUX subclass: -> EFFLUX ranB ADZ12700.1 class: -> EFFLUX subclass: -> EFFLUX vanR-Cd AXB64454.1 product_name: vancomycin resistance response regulator transcriptoin factor VanR-G-Cd -> vancomycin resistance response regulator transcription factor VanR-G-Cd mepA BAB41547.1 class: EFFLUX -> TETRACYCLINE pubmed_reference: -> 15855508 subclass: EFFLUX -> TIGECYCLINE cofA BAB62897.1 product_name: type IV pilus CFA/III major pilin -> type 4b pilus CFA/III major pilin CofA stxA1a BAC10987.1 gene_family: stxA1c -> stxA1a hierarchy_node: stxA1c -> stxA1a product_name: Shiga toxin Stx1c subunit A -> Shiga toxin Stx1a subunit A subclass: STX1C -> STX1A stxB1a BAC10988.1 gene_family: stxB1c -> stxB1a hierarchy_node: stxB1c -> stxB1a product_name: Shiga toxin Stx1c subunit B -> Shiga toxin Stx1a subunit B subclass: STX1C -> STX1A sdeY BAC77251.1 pubmed_reference: -> 12837741 emrD BAE77620.1 pubmed_reference: -> 16675700 smfY BAE79899.1 pubmed_reference: -> 17409524 ttgA BAF76383.1 pubmed_reference: -> 14506010 subtype: AMR -> BIOCIDE type: AMR -> STRESS ttgB BAF76384.1 pubmed_reference: -> 14506010 subtype: AMR -> BIOCIDE type: AMR -> STRESS smeF CAC14596.1 class: EFFLUX -> QUINOLONE pubmed_reference: -> 24837376 subclass: EFFLUX -> QUINOLONE vanZ1 CAJ68095.1 pubmed_reference: -> 29940245 emrC CAQ45062.1 pubmed_reference: -> 23794602 emrA CAQ45063.1 pubmed_reference: -> 23794602 emrB CAQ45064.1 pubmed_reference: -> 23794602 helR CCA59315.1 pubmed_reference: -> 34964291 inv CCV30618.1 product_name: autotransporter invasin Inv -> inverse autotransporter invasin Inv emrC EAC4468893.1 pubmed_reference: -> 27998823 catC KGT34314.1 product_name: type B chloramphenicol O-acetyltransferase -> type C chloramphenicol O-acetyltransferase pubmed_reference: -> 30878668,31762145 aph(3')-IId QQK39289.1 pubmed_reference: -> 34329431 ant(2'')-Ia WP_000381803.1 synonyms: -> aadB vanS-A WP_002305818.1 product_name: VanA-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-A vanS-B WP_002368696.1 product_name: VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B vanS-B WP_002382867.1 product_name: VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B ant(2'')-Ia WP_003159209.1 synonyms: -> aadB vanS-Sc WP_003975349.1 product_name: VanSc-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Sc vanR-F WP_006285581.1 product_name: VanF-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-F vanS-F WP_006285582.1 product_name: VanF-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-F tet(X2) WP_008651082.1 pubmed_reference: 33287863 -> 32938927,33287863,37141282 subclass: TETRACYCLINE -> TIGECYCLINE vanS-I WP_011461302.1 product_name: VanI-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-I vanS-B WP_012579101.1 product_name: VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B tet(X2) WP_015060600.1 subclass: TETRACYCLINE -> TIGECYCLINE vanS-G WP_021418927.1 product_name: VanG-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-G vanS-D WP_023042297.1 product_name: VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D vanS-D WP_028530133.1 product_name: VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D vanC1 WP_029487031.1 gene_family: vanC -> vanC1 crpP WP_033179079.1 product_name: ciprofloxacin resistance protein CrpP -> ICE-associated protein CrpP vanS-C WP_034869172.1 product_name: VanC-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-C vanC1 WP_040013725.1 gene_family: vanC -> vanC1 ant(2'')-Ia WP_042852798.1 synonyms: -> aadB aac(6')-Ia WP_058677876.1 synonyms: -> aacA1 tet(X2) WP_063856436.1 subclass: TETRACYCLINE -> TIGECYCLINE vanC1 WP_063856645.1 gene_family: vanC -> vanC1 vanC1 WP_063856686.1 gene_family: vanC -> vanC1 vanC1 WP_063856687.1 gene_family: vanC -> vanC1 vanC1 WP_063856688.1 gene_family: vanC -> vanC1 vanR-M WP_063856726.1 product_name: VanM-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-M vanS-D WP_063856730.1 product_name: VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D vanS-A WP_063856731.1 product_name: VanA-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-A vanS-G WP_063856732.1 product_name: VanG-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-G vanS-C WP_063856733.1 product_name: VanC-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-C vanS-E WP_063856734.1 product_name: VanE-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-E vanS-D WP_063856738.1 product_name: VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D vanS-B WP_063856739.1 product_name: VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B vanS-Pt2 WP_063856740.1 product_name: VanPt2-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt2 vanS-Pt WP_063856741.1 product_name: VanPt-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt vanS-Pt WP_063856742.1 product_name: VanPt-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt vanS-C WP_063856743.1 product_name: VanC-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-C vanS-D WP_063856744.1 product_name: VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D vanS-L WP_063856745.1 product_name: VanL-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-L vanS-M WP_063856748.1 product_name: VanM-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-M vanS-N WP_063856749.1 product_name: VanN-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-N vanS-B WP_063856751.1 product_name: VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B vanS-O WP_070064533.1 product_name: VanO-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-O dfrA1 WP_071846186.1 synonyms: -> dfr1 ant(2'')-Ia WP_071846217.1 synonyms: -> aadB ant(2'')-Ia WP_071846230.1 synonyms: -> aadB ant(2'')-Ia WP_071846238.1 synonyms: -> aadB dfrA1 WP_071846293.1 synonyms: -> dfr1 dfrA1 WP_071846295.1 synonyms: -> dfr1 ant(2'')-Ia WP_071846303.1 synonyms: -> aadB ant(2'')-Ia WP_071846305.1 synonyms: -> aadB dfrA1 WP_071846306.1 synonyms: -> dfr1 ant(2'')-Ia WP_071846312.1 synonyms: -> aadB ant(2'')-Ia WP_071846313.1 synonyms: -> aadB ant(2'')-Ia WP_071846314.1 synonyms: -> aadB ant(2'')-Ia WP_071846317.1 synonyms: -> aadB aac(6')-Il WP_071846318.1 synonyms: -> aacA7 ant(2'')-Ia WP_071846341.1 synonyms: -> aadB ant(2'')-Ia WP_071846360.1 synonyms: -> aadB dfrA1 WP_071846366.1 synonyms: -> dfr1 ant(2'')-Ia WP_071846368.1 synonyms: -> aadB dfrA1 WP_071846387.1 synonyms: -> dfr1 rphC WP_087347987.1 pubmed_reference: -> 24778229,29259290 rphD WP_087348261.1 pubmed_reference: -> 24778229,29259290 dfrA1 WP_140423283.1 synonyms: -> dfr1 vanS-P WP_222891058.1 product_name: VanP-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-P blaCMH-9 WP_058650678.1 genbank_nucleotide_accession: ABFHGH010000056.1 -> ABFHGH020000056.1 genbank_protein_accession: EIY2541268.1 -> EKU2771784.1 blaIND-19 WP_274375789.1 allele: blaIND-17 -> blaIND-19 hierarchy_node: blaIND-17 -> blaIND-19 product_name: subclass B1 metallo-beta-lactamase IND-17 -> subclass B1 metallo-beta-lactamase IND-19 blaKPC-44 WP_140423311.1 product_name: inhibitor-resistant extended-spectrum class A beta-lactamase KPC-44 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-44 subclass: CEPHALOSPORIN -> CARBAPENEM blaKPC-62 WP_204376229.1 pubmed_reference: 33775814 -> 33775814,36964710 blaMOX-18 WP_268871858.1 product_name: class C beta-lactamase MOX-18 -> CMY-1/MOX family class C beta-lactamase MOX-18 blaMOX-19 WP_268871859.1 product_name: class C beta-lactamase MOX-19 -> CMY-1/MOX family class C beta-lactamase MOX-19 blaMOX-20 WP_268871860.1 product_name: class C beta-lactamase MOX-20 -> CMY-1/MOX family class C beta-lactamase MOX-20 blaMOX-21 WP_268871861.1 product_name: class C beta-lactamase MOX-21 -> CMY-1/MOX family class C beta-lactamase MOX-21 blaMOX-22 WP_223915751.1 product_name: class C beta-lactamase MOX-22 -> CMY-1/MOX family class C beta-lactamase MOX-22 blaMOX-23 WP_180898621.1 product_name: class C beta-lactamase MOX-23 -> CMY-1/MOX family class C beta-lactamase MOX-23 blaMOX-24 WP_244054059.1 product_name: class C beta-lactamase MOX-24 -> CMY-1/MOX family class C beta-lactamase MOX-24 blaMOX-25 WP_128343957.1 product_name: class C beta-lactamase MOX-25 -> CMY-1/MOX family class C beta-lactamase MOX-25 blaNDM-50 WP_274293087.1 genbank_nucleotide_accession: ABJWWM010000052.1 -> ABJWWM020000052.1 genbank_protein_accession: EKH0703529.1 -> EKV8557274.1 blaNDM-9 WP_032495672.1 product_name: subclass B1 metallo-beta-lactamase NDM-9 -> taniborbactam-resistant subclass B1 metallo-beta-lactamase NDM-9 pubmed_reference: 24913967 -> 24913967,36796395,37394537 subclass: CARBAPENEM -> CARBAPENEM/TANIBORBACTAM blaOXA-1038 WP_231869643.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-1039 WP_037414505.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-1055 WP_240067733.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-1091 WP_012045014.1 product_name: class D beta-lactamase OXA-1091 -> oxacillin-hydrolyzing class D beta-lactamase OXA-1091 blaOXA-1119 WP_256875609.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-1146 WP_262697143.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-1181 WP_274293088.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-519 WP_094009808.1 product_name: OXA-48 family class D beta-lactamase OXA-519 -> OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-519 blaOXA-538 WP_071593227.1 product_name: OXA-48 family class D beta-lactamase OXA-538 -> OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-538 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-546 WP_087587945.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-566 WP_094009811.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-567 WP_099156052.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-793 WP_136512085.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-833 WP_140423324.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-918 WP_179284333.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-920 WP_179284336.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-922 WP_188331876.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-923 WP_179284342.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-924 WP_179284345.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-929 WP_188331878.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-933 WP_231869591.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-934 WP_231869592.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-955 WP_213994600.1 genbank_nucleotide_accession: AAYMEH010000029.1 -> AAYMEH020000029.1 genbank_protein_accession: EGY4117187.1 -> EKY1045811.1 blaRATA-2 WP_154469535.1 genbank_nucleotide_accession: QXQJ01000019.1 -> CP121210.1 genbank_protein_accession: MSN81448.1 -> WFS32678.1 genbank_start: 51 -> 1997285 genbank_stop: 965 -> 1998199 refseq_nucleotide_accession: NG_149672.1 -> NG_149672.2 refseq_start: 51 -> 101 refseq_stop: 965 -> 1015 blaSGM-5 WP_007708339.1 genbank_nucleotide_accession: AJVL01000026.1 -> CP124576.1 genbank_protein_accession: EJK84395.1 -> WHO40873.1 genbank_start: 37096 -> 2019317 genbank_stop: 38076 -> 2020297 genbank_strand: - -> + blaSHV-27 WP_023282555.1 subclass: CEPHALOSPORIN -> BETA-LACTAM blaSHV-40 WP_063864681.1 subclass: CEPHALOSPORIN -> BETA-LACTAM blaSHV-41 WP_063864682.1 subclass: CEPHALOSPORIN -> BETA-LACTAM blaSHV-42 WP_063864683.1 subclass: CEPHALOSPORIN -> BETA-LACTAM rpoB_A477D WP_000918664.1 pubmed_reference: -> 12384339 rpoB_A477V WP_000918664.1 pubmed_reference: -> 12384339 rpoB_D471G WP_000918664.1 pubmed_reference: -> 12384339 rpoB_D471Y WP_000918664.1 pubmed_reference: -> 12384339 rpoB_H481N WP_000918664.1 pubmed_reference: -> 12384339 rpoB_H481Y WP_000918664.1 pubmed_reference: -> 12384339 rpoB_I527F WP_000918664.1 pubmed_reference: -> 12384339 rpoB_I572L WP_000263098.1 pubmed_reference: -> 11102350 rpoB_P564L WP_000263098.1 pubmed_reference: -> 11102350 rpoB_Q468L WP_000918664.1 pubmed_reference: -> 12384339 rpoB_Q468R WP_000918664.1 pubmed_reference: -> 12384339 rpoB_R484H WP_000918664.1 pubmed_reference: -> 12384339 rpoB_S464P WP_000918664.1 pubmed_reference: -> 12384339 rpoB_S486L WP_000918664.1 pubmed_reference: -> 12384339 Hierarchy nodes added core AMR AMR blaAMZ blaAMZ NF041741.1 AMZ family class C beta-lactamase blaBIM blaBIM NF041846.1 BIM family subclass B1 metallo-beta-lactamase blaCHM blaCHM NF041758.1 CHM family subclass B1 metallo-beta-lactamase blaPSZ blaPSZ NF041665.1 PSZ family class C beta-lactamase dfrL dfrL NF041668.1 trimethoprim-resistant dihydrofolate reductase DfrL estT estT NF041759.1 macrolide hydrolase EstT non-reported AMR AMR IONOPHORE plus AMR AMR narA narA ionophore ABC transporter ATP-binding subunit NarA narB narB ionophore ABC transporter permease subunit NarB plus VIRULENCE VIRULENCE peg-344 peg-344 DMT family inner membrane transporter PEG344 stxA1e stxA1e NF041696.1 Shiga toxin Stx1e subunit A stxA2_acd stxA2 NF041702.1 Shiga toxin Stx2 subunit A, a/c/d subtype stxA2_eilk stxA2 NF041703.1 Shiga toxin Stx2 subunit A, e/i/l/k subtype stxA2k stxA2k Shiga toxin Stx2k subunit A stxA2o stxA2o Shiga toxin Stx2o subunit A stxB1e stxB1e NF041700.1 Shiga toxin Stx1e subunit B stxB2j stxB2j Shiga toxin Stx2j subunit B stxB2k stxB2k Shiga toxin Stx2k subunit B stxB2m stxB2m Shiga toxin Stx2m subunit B stxB2n stxB2n Shiga toxin Stx2n subunit B stxB2o stxB2o NF041701.1 Shiga toxin Stx2o subunit B Changed Hierarchy Nodes ampC_Ecan CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase hmm_acc: -> NF041666.1 ariR biofilm/acid-resistance regulator AriR symbol: ymgB -> ariR blaL2 L2 family extended-spectrum class A beta-lactamase hmm_acc: NF000232.1 -> blaOXA-1036_fam OXA-1036 family carbapenem-hydrolyzing class D beta-lactamase name: OXA-1036 family class D beta-lactamase -> OXA-1036 family carbapenem-hydrolyzing class D beta-lactamase blaOXA-1091_fam OXA-1091 family oxacillin-hydrolyzing class D beta-lactamase name: OXA-1091 family class D beta-lactamase -> OXA-1091 family oxacillin-hydrolyzing class D beta-lactamase blaOXA-9_fam OXA-9 family oxacillin-hydrolyzing class D beta-lactamase name: OXA-9 family class D beta-lactamase -> OXA-9 family oxacillin-hydrolyzing class D beta-lactamase blaSPR SPR family subclass B3 metallo-beta-lactamase hmm_acc: -> NF041137.1 blaTLA TLA family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN catC type C chloramphenicol O-acetyltransferase name: type B chloramphenicol O-acetyltransferase -> type C chloramphenicol O-acetyltransferase cofA type 4b pilus CFA/III major pilin CofA name: type IV pilus CFA/III major pilin -> type 4b pilus CFA/III major pilin CofA crpP ICE-associated protein CrpP name: ciprofloxacin resistance protein CrpP -> ICE-associated protein CrpP dfr_gen trimethoprim-resistant dihydrofolate reductase symbol: dfrA -> dfr fdeC inverse autotransporter adhesin FdeC name: intimin-like adhesin FdeC -> inverse autotransporter adhesin FdeC fosBx1-fam FosBx1 family fosfomycin resistance bacillithiol transferase hmm_acc: -> NF041541.1 fosXCC fosfomycin resistance hydrolase FosXCC hmm_acc: -> NF041542.1 inv inverse autotransporter invasin Inv name: autotransporter invasin Inv -> inverse autotransporter invasin Inv mepA multidrug efflux MATE transporter MepA class: EFFLUX -> TETRACYCLINE subclass: EFFLUX -> TIGECYCLINE ranA multidrug efflux ABC transporter ATP-binding subunit RanA class: -> EFFLUX subclass: -> EFFLUX ranB multidrug efflux ABC transporter permease subunit RanB class: -> EFFLUX subclass: -> EFFLUX rph_gen rifamycin-inactivating phosphotransferase scope: core -> non-reported smeF multidrug efflux RND transporter outer membrane subunit SmeF class: EFFLUX -> QUINOLONE subclass: EFFLUX -> QUINOLONE srpA solvent efflux RND transporter periplasmic adaptor subunit SrpA parent_node_id: RND-peri -> BIOCIDE subtype: AMR -> BIOCIDE type: AMR -> STRESS srpB solvent efflux RND transporter permease subunit SrpB parent_node_id: RND-IM -> BIOCIDE subtype: AMR -> BIOCIDE type: AMR -> STRESS srpC solvent efflux RND transporter outer membrane subunit SrpC parent_node_id: RND-OM -> BIOCIDE subtype: AMR -> BIOCIDE type: AMR -> STRESS stxA1a Shiga toxin Stx1a subunit A hmm_acc: -> NF041694.1 stxA1c Shiga toxin Stx1c subunit A hmm_acc: -> NF041693.1 stxA1d Shiga toxin Stx1d subunit A hmm_acc: -> NF041695.1 stxA2a Shiga toxin Stx2a subunit A parent_node_id: stxA2 -> stxA2_acd stxA2b Shiga toxin Stx2b subunit A hmm_acc: -> NF041688.1 stxA2c Shiga toxin Stx2c subunit A parent_node_id: stxA2 -> stxA2_acd stxA2d Shiga toxin Stx2d subunit A parent_node_id: stxA2 -> stxA2_acd stxA2e Shiga toxin Stx2e subunit A parent_node_id: stxA2 -> stxA2_eilk stxA2f Shiga toxin Stx2f subunit A hmm_acc: -> NF041687.1 stxA2g Shiga toxin Stx2g subunit A hmm_acc: -> NF041690.1 stxA2i Shiga toxin Stx2i subunit A parent_node_id: stxA2 -> stxA2_eilk stxA2j Shiga toxin Stx2j subunit A hmm_acc: -> NF041689.1 stxA2l Shiga toxin Stx2l subunit A parent_node_id: stxA2 -> stxA2_eilk stxB1a Shiga toxin Stx1a subunit B hmm_acc: -> NF041697.1 stxB1c Shiga toxin Stx1c subunit B hmm_acc: -> NF041698.1 stxB1d Shiga toxin Stx1d subunit B hmm_acc: -> NF041699.1 stxB2b Shiga toxin Stx2b subunit B hmm_acc: -> NF041691.1 stxB2e Shiga toxin Stx2e subunit B hmm_acc: -> NF041704.1 stxB2f Shiga toxin Stx2f subunit B hmm_acc: -> NF041692.1 tet(X2) tetracycline-inactivating monooxygenase Tet(X2) subclass: TETRACYCLINE -> TIGECYCLINE ttgA toluene efflux RND transporter periplasmic adaptor subunit TtgA parent_node_id: RND-peri -> BIOCIDE subtype: AMR -> BIOCIDE type: AMR -> STRESS ttgB multidrug efflux RND transporter permease subunit TtgB parent_node_id: RND-IM -> BIOCIDE subtype: AMR -> BIOCIDE type: AMR -> STRESS ttgD toluene efflux RND transporter periplasmic adaptor subunit TtgD parent_node_id: RND-peri -> BIOCIDE subtype: AMR -> BIOCIDE type: AMR -> STRESS ttgE multidrug efflux RND transporter permease subunit TtgE parent_node_id: RND-IM -> BIOCIDE subtype: AMR -> BIOCIDE type: AMR -> STRESS vanC1 D-alanine--D-serine ligase VanC1 symbol: vanC -> vanC1 vanR-Cd vancomycin resistance response regulator transcription factor VanR-G-Cd name: vancomycin resistance response regulator transcriptoin factor VanR-G-Cd -> vancomycin resistance response regulator transcription factor VanR-G-Cd vanR-F vancomycin resistance response regulator transcription factor VanR-F name: VanF-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-F vanR-FM vancomycin resistance response regulator transcription factor, VanR-F/VanR-M family name: vancomycin resistance response regulator transcription factor VanR-FM -> vancomycin resistance response regulator transcription factor, VanR-F/VanR-M family vanR-M vancomycin resistance response regulator transcription factor VanR-M name: VanM-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-M vanS-A vancomycin resistance histidine kinase VanS-A name: VanA-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-A vanS-B vancomycin resistance histidine kinase VanS-B name: VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B vanS-C vancomycin resistance histidine kinase VanS-C name: VanC-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-C vanS-D vancomycin resistance histidine kinase VanS-D name: VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D vanS-E vancomycin resistance histidine kinase VanS-E name: VanE-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-E vanS-F vancomycin resistance histidine kinase VanS-F name: VanF-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-F vanS-G vancomycin resistance histidine kinase VanS-G name: VanG-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-G vanS-I vancomycin resistance histidine kinase VanS-I name: VanI-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-I vanS-L vancomycin resistance histidine kinase VanS-L name: VanL-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-L vanS-M vancomycin resistance histidine kinase VanS-M name: VanM-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-M vanS-N vancomycin resistance histidine kinase VanS-N name: VanN-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-N vanS-O vancomycin resistance histidine kinase VanS-O name: VanO-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-O vanS-P vancomycin resistance histidine kinase VanS-P name: VanP-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-P vanS-Pt vancomycin resistance histidine kinase VanS-Pt name: VanPt-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt vanS-Pt2 vancomycin resistance histidine kinase VanS-Pt2 name: VanPt2-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt2 vanS-Sc vancomycin resistance histidine kinase VanS-Sc name: VanSc-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Sc ---------------------------------------------------------------------- Changes included in 2023-04-17.1 ---------------------------------------------------------------------- Overview: - We reviewed and refined phenotype information in product name for 57 blaPDC alleles (inhibitor-resistant and/or extended-spectrum) - New refined subclasses for some blaOXA and blaKPC alleles, and the blaOXA-427 family - Added phenotype information in the subclass field for some unnamed ampC genes - four new HMMs - added 112 new beta-lactamase alleles - Point mutation detection expanded to include resistance mutations in Citrobacter_freundii, Enterobacter_cloacae, Klebsiella_aerogenes, and Serratia_marcescens - 121 new point mutations for Pseudomonas_aeruginosa Summary: Total proteins: 7739 Core proteins: 6648 Plus proteins: 1090 AMR proteins: 6696 STRESS proteins: 235 VIRULENCE proteins: 808 PubMed references: 3428 Point mutations: 1151 Point mutation reference sequences: 202 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 692 Updates since release 2023-02-23.1: Proteins added: 112 Core proteins added: 112 Plus proteins added: 0 AMR proteins added: 112 Alleles added: 112 PubMed references added: 516 Point mutations added: 138 Reference Gene Catalog entries changed: 367 Hierarchy nodes added: 4 Hierarchy nodes changed: 2 HMMs added: 4 Added proteins core AMR AMR blaACT-112 NG_156952.1 WP_134179367.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-112 blaACT-113 NG_156953.1 WP_279240765.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-113 blaACT-114 NG_156954.1 WP_180255442.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-114 blaACT-115 NG_156955.1 WP_058652386.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-115 blaACT-116 NG_156956.1 WP_073000989.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-116 blaACT-117 NG_156957.1 WP_279240766.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-117 blaACT-118 NG_156958.1 WP_279240767.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-118 blaACT-119 NG_156959.1 WP_279240768.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-119 blaADC-292 NG_156960.1 WP_274858813.1 extended-spectrum class C beta-lactamase ADC-292 blaADC-293 NG_156961.1 WP_279240769.1 extended-spectrum class C beta-lactamase ADC-293 blaADC-294 NG_156962.1 WP_279240770.1 extended-spectrum class C beta-lactamase ADC-294 blaADC-295 NG_156963.1 WP_009389984.1 extended-spectrum class C beta-lactamase ADC-295 blaADC-302 NG_156964.1 WP_001211202.1 extended-spectrum class C beta-lactamase ADC-302 blaADC-303 NG_156965.1 WP_001211225.1 extended-spectrum class C beta-lactamase ADC-303 blaADC-304 NG_156966.1 WP_272307067.1 extended-spectrum class C beta-lactamase ADC-304 blaADC-305 NG_156967.1 WP_272267218.1 extended-spectrum class C beta-lactamase ADC-305 blaADC-306 NG_156968.1 WP_272372047.1 extended-spectrum class C beta-lactamase ADC-306 blaADC-307 NG_156969.1 WP_272247217.1 extended-spectrum class C beta-lactamase ADC-307 blaADC-308 NG_156970.1 WP_065712098.1 extended-spectrum class C beta-lactamase ADC-308 blaADC-309 NG_156971.1 WP_272326044.1 extended-spectrum class C beta-lactamase ADC-309 blaADC-310 NG_156972.1 WP_032029974.1 extended-spectrum class C beta-lactamase ADC-310 blaADC-311 NG_156973.1 WP_174749605.1 extended-spectrum class C beta-lactamase ADC-311 blaADC-312 NG_156974.1 WP_261470340.1 extended-spectrum class C beta-lactamase ADC-312 blaADC-313 NG_156975.1 WP_272333251.1 extended-spectrum class C beta-lactamase ADC-313 blaADC-314 NG_156976.1 WP_272290549.1 extended-spectrum class C beta-lactamase ADC-314 blaADC-315 NG_156977.1 WP_031380135.1 extended-spectrum class C beta-lactamase ADC-315 blaADC-316 NG_156978.1 WP_272273772.1 extended-spectrum class C beta-lactamase ADC-316 blaADC-317 NG_156979.1 WP_272389475.1 extended-spectrum class C beta-lactamase ADC-317 blaADC-318 NG_156980.1 WP_272311194.1 extended-spectrum class C beta-lactamase ADC-318 blaADC-319 NG_156981.1 WP_272284684.1 extended-spectrum class C beta-lactamase ADC-319 blaADC-320 NG_156982.1 WP_272236549.1 extended-spectrum class C beta-lactamase ADC-320 blaADC-321 NG_156983.1 WP_262093836.1 extended-spectrum class C beta-lactamase ADC-321 blaADC-322 NG_156984.1 WP_272291658.1 extended-spectrum class C beta-lactamase ADC-322 blaADC-323 NG_156985.1 WP_272359117.1 extended-spectrum class C beta-lactamase ADC-323 blaADC-324 NG_156986.1 WP_272276659.1 extended-spectrum class C beta-lactamase ADC-324 blaADC-325 NG_156987.1 WP_261479309.1 extended-spectrum class C beta-lactamase ADC-325 blaADC-326 NG_156988.1 WP_272315880.1 extended-spectrum class C beta-lactamase ADC-326 blaADC-327 NG_156989.1 WP_272291558.1 extended-spectrum class C beta-lactamase ADC-327 blaADC-328 NG_156990.1 WP_069370341.1 extended-spectrum class C beta-lactamase ADC-328 blaADC-329 NG_156991.1 WP_272312953.1 extended-spectrum class C beta-lactamase ADC-329 blaADC-330 NG_156992.1 WP_272357959.1 extended-spectrum class C beta-lactamase ADC-330 blaADC-331 NG_156993.1 WP_272305010.1 extended-spectrum class C beta-lactamase ADC-331 blaADC-332 NG_156994.1 WP_272289597.1 extended-spectrum class C beta-lactamase ADC-332 blaADC-333 NG_156995.1 WP_272321894.1 extended-spectrum class C beta-lactamase ADC-333 blaCAE-1 NG_156996.1 WP_158386862.1 broad-spectrum class A beta-lactamase CAE-1 blaCMH-10 NG_156997.1 WP_155023054.1 class C beta-lactamase CMH-10 blaCMH-11 NG_157062.1 WP_279383145.1 class C beta-lactamase CMH-11 blaCMH-12 NG_157063.1 WP_279383146.1 class C beta-lactamase CMH-12 blaCMH-9 NG_156998.1 WP_058650678.1 class C beta-lactamase CMH-9 blaFONA-10 NG_156999.1 WP_121606866.1 class A beta-lactamase FONA-10 blaFONA-11 NG_157000.1 WP_021806421.1 class A beta-lactamase FONA-11 blaFONA-12 NG_157001.1 WP_209522946.1 class A beta-lactamase FONA-12 blaFONA-13 NG_157002.1 WP_279240771.1 class A beta-lactamase FONA-13 blaFONA-8 NG_157003.1 WP_024530279.1 class A beta-lactamase FONA-8 blaFONA-9 NG_157004.1 WP_279240772.1 class A beta-lactamase FONA-9 blaGES-58 NG_157005.1 WP_279240773.1 class A beta-lactamase GES-58 blaIMP-99 NG_157006.1 WP_279240774.1 subclass B1 metallo-beta-lactamase IMP-99 blaKPC-136 NG_157007.1 WP_279240775.1 carbapenem-hydrolyzing class A beta-lactamase KPC-136 blaKPC-159 NG_157008.1 WP_279240776.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-159 blaKPC-160 NG_157009.1 WP_279240777.1 carbapenem-hydrolyzing class A beta-lactamase KPC-160 blaKPC-161 NG_157010.1 WP_279240778.1 carbapenem-hydrolyzing class A beta-lactamase KPC-161 blaKPC-162 NG_157011.1 WP_279240779.1 carbapenem-hydrolyzing class A beta-lactamase KPC-162 blaKPC-163 NG_157012.1 WP_279240780.1 carbapenem-hydrolyzing class A beta-lactamase KPC-163 blaKPC-164 NG_157013.1 WP_279240781.1 carbapenem-hydrolyzing class A beta-lactamase KPC-164 blaKPC-165 NG_157014.1 WP_279240782.1 carbapenem-hydrolyzing class A beta-lactamase KPC-165 blaKPC-166 NG_157015.1 WP_279240783.1 carbapenem-hydrolyzing class A beta-lactamase KPC-166 blaKPC-167 NG_157016.1 WP_279240784.1 class A beta-lactamase KPC-167 blaNDM-51 NG_157017.1 WP_279240785.1 subclass B1 metallo-beta-lactamase NDM-51 blaNDM-52 NG_157018.1 WP_279240786.1 subclass B1 metallo-beta-lactamase NDM-52 blaNDM-53 NG_157019.1 WP_279240787.1 subclass B1 metallo-beta-lactamase NDM-53 blaNDM-54 NG_157020.1 WP_279240788.1 subclass B1 metallo-beta-lactamase NDM-54 blaNDM-55 NG_157021.1 WP_279240789.1 subclass B1 metallo-beta-lactamase NDM-55 blaOXA-1088 NG_157022.1 WP_279240790.1 OXA-10 family class D beta-lactamase OXA-1088 blaOXA-1109 NG_157023.1 WP_279240791.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1109 blaOXA-1110 NG_157024.1 WP_253114439.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1110 blaOXA-1111 NG_157025.1 WP_279240792.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1111 blaOXA-1112 NG_157026.1 WP_253147258.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1112 blaOXA-1113 NG_157027.1 WP_279240793.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1113 blaOXA-1114 NG_157028.1 WP_262451630.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1114 blaOXA-1115 NG_157029.1 WP_279240794.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1115 blaOXA-1116 NG_157030.1 WP_279240795.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1116 blaOXA-1186 NG_157031.1 WP_279240796.1 OXA-198 family carbapenem-hydrolyzing class D beta-lactamase OXA-1186 blaOXA-1187 NG_157032.1 WP_279240797.1 OXA-2 family class D beta-lactamase OXA-1187 blaOXA-1188 NG_157033.1 WP_200582679.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1188 blaOXA-1189 NG_157034.1 WP_009388658.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1189 blaOXA-1190 NG_157035.1 WP_139419258.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1190 blaOXA-1191 NG_157036.1 WP_058968329.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1191 blaOXA-1192 NG_157037.1 WP_274945001.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1192 blaOXA-1193 NG_157038.1 WP_151798075.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1193 blaOXA-1194 NG_157039.1 WP_199935335.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1194 blaOXA-1195 NG_157040.1 WP_151825371.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1195 blaOXA-1196 NG_157041.1 WP_151810644.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1196 blaOXA-1197 NG_157042.1 WP_151713720.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1197 blaOXA-1198 NG_157043.1 WP_279240798.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1198 blaOXA-1199 NG_157066.1 WP_034021370.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1199 blaPDC-513 NG_157044.1 WP_279240799.1 class C beta-lactamase PDC-513 blaPDC-543 NG_157045.1 WP_279240800.1 class C beta-lactamase PDC-543 blaPDC-544 NG_157046.1 WP_279240801.1 class C beta-lactamase PDC-544 blaPDC-545 NG_157047.1 WP_279240802.1 class C beta-lactamase PDC-545 blaPDC-546 NG_157048.1 WP_209359118.1 class C beta-lactamase PDC-546 blaPDC-547 NG_157049.1 WP_275802705.1 class C beta-lactamase PDC-547 blaPDC-548 NG_157050.1 WP_279240803.1 class C beta-lactamase PDC-548 blaPDC-549 NG_157051.1 WP_279240804.1 class C beta-lactamase PDC-549 blaPDC-550 NG_157052.1 WP_279240805.1 class C beta-lactamase PDC-550 blaPDC-551 NG_157053.1 WP_279240806.1 class C beta-lactamase PDC-551 blaPDC-552 NG_157054.1 WP_279240807.1 class C beta-lactamase PDC-552 blaRAHN-3 NG_157055.1 WP_013578129.1 extended-spectrum class A beta-lactamase RAHN-3 blaRAHN-4 NG_157056.1 WP_112286530.1 extended-spectrum class A beta-lactamase RAHN-4 blaRAHN-5 NG_157057.1 WP_279240808.1 extended-spectrum class A beta-lactamase RAHN-5 blaRAHN-6 NG_157058.1 WP_113877255.1 extended-spectrum class A beta-lactamase RAHN-6 blaTEM-250 NG_157060.1 WP_279240809.1 class A beta-lactamase TEM-250 blaVIM-81 NG_157061.1 WP_258164747.1 subclass B1 metallo-beta-lactamase VIM-81 Added point mutations core AMR POINT amgS_P381S CARBAPENEM Pseudomonas_aeruginosa amgS_R182C AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa amgS_V121G AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa ampD_E67STOP CEPHALOSPORIN Pseudomonas_aeruginosa ampD_Q155STOP CEPHALOSPORIN Pseudomonas_aeruginosa ampD_Q44STOP CEPHALOSPORIN Pseudomonas_aeruginosa ampR_R86C CEPHALOSPORIN Pseudomonas_aeruginosa cirA_R86S CEFIDEROCOL Escherichia cmrA_A68V CHLORAMPHENICOL/IMIPENEM/QUINOLONE Pseudomonas_aeruginosa cmrA_H204L CHLORAMPHENICOL/IMIPENEM/QUINOLONE Pseudomonas_aeruginosa cmrA_L89Q CHLORAMPHENICOL/IMIPENEM/QUINOLONE Pseudomonas_aeruginosa cmrA_N214K CHLORAMPHENICOL/IMIPENEM/QUINOLONE Pseudomonas_aeruginosa colR_D32N COLISTIN Pseudomonas_aeruginosa colS_A106V COLISTIN Pseudomonas_aeruginosa cprS_R241C COLISTIN Pseudomonas_aeruginosa czcS_V194L CARBAPENEM Pseudomonas_aeruginosa ftsI_A419G CARBAPENEM Pseudomonas_aeruginosa ftsI_A454V CARBAPENEM Pseudomonas_aeruginosa ftsI_F507L CARBAPENEM Pseudomonas_aeruginosa ftsI_F533L CARBAPENEM Pseudomonas_aeruginosa ftsI_G63S CARBAPENEM Pseudomonas_aeruginosa ftsI_H394R CARBAPENEM Pseudomonas_aeruginosa ftsI_L434V CARBAPENEM Pseudomonas_aeruginosa ftsI_L461V CARBAPENEM Pseudomonas_aeruginosa ftsI_N427L CARBAPENEM Pseudomonas_aeruginosa ftsI_N427S CARBAPENEM Pseudomonas_aeruginosa ftsI_P527S CARBAPENEM Pseudomonas_aeruginosa ftsI_Q458R CARBAPENEM Pseudomonas_aeruginosa ftsI_Q475R CARBAPENEM Pseudomonas_aeruginosa ftsI_R504C CARBAPENEM Pseudomonas_aeruginosa ftsI_R504L CARBAPENEM Pseudomonas_aeruginosa ftsI_S368L CARBAPENEM Pseudomonas_aeruginosa ftsI_S538L CARBAPENEM Pseudomonas_aeruginosa ftsI_V471G CARBAPENEM Pseudomonas_aeruginosa ftsI_V523A CARBAPENEM Pseudomonas_aeruginosa ftsI_V523M CARBAPENEM Pseudomonas_aeruginosa ftsI_Y367C CARBAPENEM Pseudomonas_aeruginosa fusA1_A555E AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_A595P TOBRAMYCIN Pseudomonas_aeruginosa fusA1_E100G AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_G545D TOBRAMYCIN Pseudomonas_aeruginosa fusA1_I61M AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_K504Q AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_L438Q AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_L464V AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_N592I AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_P554L AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_P618L TOBRAMYCIN Pseudomonas_aeruginosa fusA1_Q455R AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_Q678L AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_R371C AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_R680C AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_T456A AMIKACIN Pseudomonas_aeruginosa fusA1_T671A AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_T671I AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa fusA1_Y552C AMIKACIN Pseudomonas_aeruginosa gyrA_D72G QUINOLONE Pseudomonas_aeruginosa gyrA_D87G QUINOLONE Citrobacter_freundii gyrA_D87G QUINOLONE Klebsiella_oxytoca gyrA_D87G QUINOLONE Enterobacter_cloacae gyrA_D87H QUINOLONE Enterobacter_cloacae gyrA_D87N QUINOLONE Enterobacter_cloacae gyrA_D87N QUINOLONE Serratia_marcescens gyrA_D87Y QUINOLONE Pseudomonas_aeruginosa gyrA_G81C QUINOLONE Pseudomonas_aeruginosa gyrA_G81D QUINOLONE Pseudomonas_aeruginosa gyrA_Q106L QUINOLONE Pseudomonas_aeruginosa gyrA_S83F QUINOLONE Enterobacter_cloacae gyrA_S83I QUINOLONE Enterobacter_cloacae gyrA_S83I QUINOLONE Serratia_marcescens gyrA_S83R QUINOLONE Serratia_marcescens gyrA_S83Y QUINOLONE Enterobacter_cloacae gyrA_T83A QUINOLONE Pseudomonas_aeruginosa gyrA_T83I QUINOLONE Citrobacter_freundii gyrA_T83I QUINOLONE Klebsiella_oxytoca gyrA_Y86N QUINOLONE Pseudomonas_aeruginosa gyrB_A372L QUINOLONE Pseudomonas_aeruginosa gyrB_A372V QUINOLONE Pseudomonas_aeruginosa gyrB_E468D QUINOLONE Pseudomonas_aeruginosa gyrB_E468H QUINOLONE Pseudomonas_aeruginosa gyrB_E483D QUINOLONE Pseudomonas_aeruginosa gyrB_I424L QUINOLONE Pseudomonas_aeruginosa gyrB_L464I QUINOLONE Pseudomonas_aeruginosa gyrB_S466F QUINOLONE Pseudomonas_aeruginosa gyrB_S466Y QUINOLONE Pseudomonas_aeruginosa mexR_L57P CEPHALOSPORIN Pseudomonas_aeruginosa mexR_R70Q CEPHALOSPORIN Pseudomonas_aeruginosa mexR_R83C CARBAPENEM Pseudomonas_aeruginosa mexT_G300S CHLORAMPHENICOL/QUINOLONE/TRIMETHOPRIM Pseudomonas_aeruginosa nalC_K58E CARBAPENEM Pseudomonas_aeruginosa nalC_S127P CARBAPENEM Pseudomonas_aeruginosa nalD_F198L AZTREONAM Pseudomonas_aeruginosa nfxB_A38G QUINOLONE Pseudomonas_aeruginosa nfxB_R42G QUINOLONE Pseudomonas_aeruginosa nfxB_R42H COLISTIN Pseudomonas_aeruginosa nfxB_T39P QUINOLONE Pseudomonas_aeruginosa oprD_E176STOP CARBAPENEM Pseudomonas_aeruginosa oprD_E264STOP CARBAPENEM Pseudomonas_aeruginosa oprD_G317R CARBAPENEM Pseudomonas_aeruginosa oprD_L11P CARBAPENEM Pseudomonas_aeruginosa oprD_Q250STOP CARBAPENEM Pseudomonas_aeruginosa oprD_S223P CARBAPENEM Pseudomonas_aeruginosa oprD_S251STOP CARBAPENEM Pseudomonas_aeruginosa oprD_S319STOP CARBAPENEM Pseudomonas_aeruginosa oprD_W277STOP CARBAPENEM Pseudomonas_aeruginosa parC_S80I QUINOLONE Klebsiella_oxytoca parC_S80I QUINOLONE Enterobacter_cloacae parC_S80R QUINOLONE Klebsiella_oxytoca parC_S87W QUINOLONE Pseudomonas_aeruginosa parE_E459D QUINOLONE Pseudomonas_aeruginosa parE_E459L QUINOLONE Pseudomonas_aeruginosa parE_S457G QUINOLONE Pseudomonas_aeruginosa parE_S457T QUINOLONE Pseudomonas_aeruginosa parS_A296P COLISTIN Pseudomonas_aeruginosa parS_G361R COLISTIN Pseudomonas_aeruginosa parS_L14Q CARBAPENEM Pseudomonas_aeruginosa parS_V295L COLISTIN Pseudomonas_aeruginosa phoP_N188H COLISTIN Pseudomonas_aeruginosa phoP_N188Y COLISTIN Pseudomonas_aeruginosa pmrA_L157Q COLISTIN Pseudomonas_aeruginosa pmrB_A247T COLISTIN Pseudomonas_aeruginosa pmrB_A248V COLISTIN Pseudomonas_aeruginosa pmrB_A54V COLISTIN Pseudomonas_aeruginosa pmrB_D47del COLISTIN Pseudomonas_aeruginosa pmrB_G188D COLISTIN Pseudomonas_aeruginosa pmrB_L14P COLISTIN Pseudomonas_aeruginosa pmrB_L167P COLISTIN Pseudomonas_aeruginosa pmrB_L17Q COLISTIN Pseudomonas_aeruginosa pmrB_L243Q COLISTIN Pseudomonas_aeruginosa pmrB_M292T COLISTIN Pseudomonas_aeruginosa pmrB_P456S COLISTIN Pseudomonas_aeruginosa pmrB_R259H COLISTIN Pseudomonas_aeruginosa pmrB_S257D COLISTIN Pseudomonas_aeruginosa pmrB_T253M COLISTIN Pseudomonas_aeruginosa pmrB_V281I COLISTIN Pseudomonas_aeruginosa pmrB_V9A COLISTIN Pseudomonas_aeruginosa rplB_G138D TOBRAMYCIN Pseudomonas_aeruginosa rplB_G138L AMIKACIN Pseudomonas_aeruginosa Changed reference gene catalog records floR WP_000214123.1 pubmed_reference: -> 10991873,15855539 mef(A) WP_000417517.1 pubmed_reference: -> 8971709 mef(A) WP_000417519.1 pubmed_reference: -> 9333056 msr(D) WP_000420313.1 pubmed_reference: -> 11398110 sat4 WP_000627290.1 pubmed_reference: -> 11600397 lnu(A) WP_000700648.1 pubmed_reference: -> 17329268 mecA WP_000721309.1 pubmed_reference: -> 11302791,12654286 mecA WP_000721310.1 pubmed_reference: -> 11418146 blaZ WP_000733285.1 pubmed_reference: -> 11418146 bla2 WP_000799223.1 pubmed_reference: -> 12533457 mecR1 WP_000952923.1 pubmed_reference: -> 11418146 aacA57-2 WP_000959805.1 pubmed_reference: -> 9371347 subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN sul2 WP_001043260.1 pubmed_reference: -> 11600347 tet(B) WP_001089068.1 pubmed_reference: -> 11553538 aadA1 WP_001206317.1 pubmed_reference: -> 1334268,2821509 aadA1 WP_001209508.1 pubmed_reference: -> 11114922 bleO WP_001242578.1 pubmed_reference: -> 12654286 ant(6)-Ia WP_001255866.1 pubmed_reference: -> 11600397 tet(C) WP_001297013.1 pubmed_reference: -> 12151232 aadA7 WP_001436322.1 pubmed_reference: -> 10817710 floR WP_001694495.1 pubmed_reference: -> 11101601 floR WP_001747811.1 pubmed_reference: -> 10339826 lnu(A) WP_001829870.1 pubmed_reference: -> 17329268 dfrA15 WP_001830196.1 pubmed_reference: -> 10681329 vanX-B WP_002317266.1 pubmed_reference: -> 11376048 vanR-B WP_002317273.1 pubmed_reference: -> 11376048 vanS-B WP_002382867.1 pubmed_reference: -> 10846226 vanH-B WP_002382874.1 pubmed_reference: -> 11376048 catA WP_002403315.1 pubmed_reference: -> 11257023 vanY-B WP_002416070.1 pubmed_reference: -> 10846226 catP WP_002570989.1 pubmed_reference: -> 7565113 catB7 WP_003112709.1 pubmed_reference: -> 10361706 vanR-C WP_003126775.1 pubmed_reference: -> 10817725 vanT-C WP_003126777.1 pubmed_reference: -> 10209740,10817725 vanXY-C WP_003126779.1 pubmed_reference: -> 10564477,10817725 blaC WP_003410677.1 pubmed_reference: -> 9145897 tet(V) WP_003896589.1 pubmed_reference: -> 9687386 lnu(AN2) WP_004308783.1 pubmed_reference: -> 10852890 vanR-C WP_005228837.1 pubmed_reference: -> 12234834 vanXY-C WP_005228842.1 pubmed_reference: -> 19216682 vanC WP_005228844.1 pubmed_reference: -> 19216682 cmx WP_005297378.1 pubmed_reference: -> 10732668 ampC WP_006178946.1 hierarchy_node: CMY2-MIR-ACT-EC -> ampC_Ecan product_name: CMY2/MIR/ACT/EC family class C beta-lactamase -> CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN tetA(P) WP_006440994.1 pubmed_reference: -> 11524166 vanXY-C WP_008377360.1 pubmed_reference: -> 19216682 tet(B) WP_010446567.1 pubmed_reference: -> 12957921 str WP_010711054.1 pubmed_reference: -> 11257023 vanXY-C WP_010749757.1 pubmed_reference: -> 12615874 erm(C) WP_010889933.1 pubmed_reference: -> 3084450,3091582 aph(3')-Id WP_010891085.1 pubmed_reference: -> 2653965 tet(30) WP_010973639.1 pubmed_reference: -> 9882678 tet(C) WP_010981361.1 pubmed_reference: -> 12151232 erm(X) WP_011116967.1 pubmed_reference: -> 8559800 tetB WP_011116970.1 pubmed_reference: -> 10220896 erm(T) WP_011117197.1 pubmed_reference: -> 11375658 lnu(A) WP_011645010.1 pubmed_reference: -> 17329268 lnu(A) WP_011645013.1 pubmed_reference: -> 17329268 lnu(A) WP_011645015.1 pubmed_reference: -> 17329268 erm(B) WP_011861426.1 pubmed_reference: -> 10639372,11577151 blaPEN-E WP_011882713.1 pubmed_reference: -> 19075063 tet(B) WP_014386815.1 pubmed_reference: -> 12957921 vanB WP_014387148.1 pubmed_reference: -> 15616278 tet(O/32/O) WP_015573056.1 pubmed_reference: -> 11600392 vanR-D WP_016295750.1 pubmed_reference: -> 15308604 aph(2'')-IIa WP_016439437.1 pubmed_reference: -> 10991878 mef(A) WP_018374806.1 pubmed_reference: -> 14605159 vanG WP_021418924.1 pubmed_reference: -> 14617152 vanU-G WP_021418929.1 pubmed_reference: -> 14617152 aadA6 WP_022675713.1 pubmed_reference: -> 10673049 vanS-D WP_023042297.1 pubmed_reference: -> 15308604 vanH-D WP_023042299.1 pubmed_reference: -> 15308604 vanD WP_023042300.1 pubmed_reference: -> 15308604 vanH-D WP_028530134.1 pubmed_reference: -> 10835012 tet(B) WP_031942563.1 pubmed_reference: -> 6298728,6319234 tet(G) WP_032488557.1 pubmed_reference: -> 1479961 nimA WP_032488596.1 pubmed_reference: -> 8067736 erm(C) WP_032489009.1 pubmed_reference: -> 9169203 erm(C) WP_032489010.1 pubmed_reference: -> 9215582 erm(C) WP_032489011.1 pubmed_reference: -> 9215582 erm(C) WP_032489016.1 pubmed_reference: -> 9742700 aadA1 WP_032489308.1 pubmed_reference: -> 9835490 vgb(A) WP_032489636.1 pubmed_reference: -> 3149758 vat(E) WP_032489640.1 pubmed_reference: -> 10602747 erm(B) WP_032489723.1 pubmed_reference: -> 11023445 vanR-B WP_032489743.1 pubmed_reference: -> 10846226 vanW-B WP_032489744.1 pubmed_reference: -> 10846226 vanH-B WP_032489745.1 pubmed_reference: -> 10846226 vanB WP_032489746.1 pubmed_reference: -> 10846226 vanX-B WP_032489747.1 pubmed_reference: -> 10846226 aac(6')-Ia WP_032489895.1 pubmed_reference: -> 11114922 cmlA5 WP_032489896.1 pubmed_reference: -> 11114922 vga(B) WP_032490156.1 pubmed_reference: -> 9427556 aadA1 WP_032490440.1 pubmed_reference: -> 19719593 aadA1 WP_032490443.1 pubmed_reference: -> 19719593 aadA5 WP_032490444.1 pubmed_reference: -> 19719593 aadA1 WP_032490451.1 pubmed_reference: -> 19719593 tet(H) WP_032490787.1 pubmed_reference: -> 8109938 aac(3)-Ia WP_032491356.1 pubmed_reference: -> 9835490 aac(3)-Ia WP_032492247.1 pubmed_reference: -> 2549372 blaL1 WP_032966056.1 pubmed_reference: -> 9593158 vanR-C WP_034872470.1 pubmed_reference: -> 19216682 blaSRT WP_047567658.1 pubmed_reference: -> 11451693 tet(O) WP_050824634.1 pubmed_reference: -> 15184185 aac(6')-Ian WP_051139090.1 pubmed_reference: -> 9371347 vanB WP_060763488.1 pubmed_reference: -> 15616278 vanC WP_060792851.1 pubmed_reference: -> 19216682 vanXY-C WP_060792852.1 pubmed_reference: -> 19216682 ampC WP_063406924.1 hierarchy_node: CMY2-MIR-ACT-EC -> ampC_Kaer product_name: CMY2/MIR/ACT/EC family class C beta-lactamase -> CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase pubmed_reference: -> 11036041 subclass: BETA-LACTAM -> CEPHALOSPORIN aac(3)-Ia WP_063840257.1 pubmed_reference: -> 19719593 aadA4 WP_063840443.1 pubmed_reference: -> 10639362 aadA8 WP_063840457.1 pubmed_reference: -> 11557503 aph(3')-IIIa WP_063841495.1 pubmed_reference: -> 11600397 blaL1 WP_063842669.1 pubmed_reference: -> 11158734 blaL1 WP_063842676.1 pubmed_reference: -> 11158734 catA1 WP_063843218.1 pubmed_reference: -> 11553538 cfxA WP_063843238.1 pubmed_reference: -> 12697645 cfxA WP_063843239.1 pubmed_reference: -> 12697645 cfxA WP_063843240.1 pubmed_reference: -> 12697645 cfxA WP_063843241.1 pubmed_reference: -> 12697645 cfxA2 WP_063843242.1 pubmed_reference: -> 12697645 cfxA2 WP_063843243.1 pubmed_reference: -> 12697645 cphA1 WP_063844282.1 pubmed_reference: -> 1856163 cpt WP_063844287.1 pubmed_reference: -> 7592948 dfrA5 WP_063844445.1 pubmed_reference: -> 19719593 ere(A) WP_063844484.1 pubmed_reference: -> 11557503 erm(W) WP_063844871.1 pubmed_reference: -> 8163173 erm(X) WP_063844889.1 pubmed_reference: -> 11408212 erm(X) WP_063844894.1 pubmed_reference: -> 11408212 floR WP_063845037.1 pubmed_reference: -> 11600347 floR WP_063845065.1 pubmed_reference: -> 15251195 floR WP_063845073.1 pubmed_reference: -> 15251195 mecA WP_063852626.1 pubmed_reference: -> 17005735 mecA2 WP_063852694.1 pubmed_reference: -> 17005735 mef(A) WP_063853563.1 pubmed_reference: -> 14605159 mef(A) WP_063853574.1 pubmed_reference: -> 14605159 mph(C) WP_063853881.1 pubmed_reference: -> 9809423 mph(C) WP_063854131.1 pubmed_reference: -> 17005735 mph(C) WP_063854137.1 pubmed_reference: -> 17005735 mph(C) WP_063854150.1 pubmed_reference: -> 17005735 msr(A) WP_063854317.1 pubmed_reference: -> 9809423 msr(C) WP_063854349.1 pubmed_reference: -> 11120975 myrA WP_063854489.1 pubmed_reference: -> 8163173 nimB WP_063854490.1 pubmed_reference: -> 8067736 nimC WP_063854491.1 pubmed_reference: -> 7773395 nimD WP_063854492.1 pubmed_reference: -> 7773395 nshR WP_063854493.1 pubmed_reference: -> 2401410 blaPEN-I WP_063854501.1 pubmed_reference: -> 12821450 tet(B) WP_063856066.1 pubmed_reference: -> 12957921 tet(B) WP_063856067.1 pubmed_reference: -> 12957921 tet(D) WP_063856075.1 pubmed_reference: -> 12957921 tet(G) WP_063856077.1 pubmed_reference: -> 12957921 tet(M) WP_063856111.1 pubmed_reference: -> 9372426 tet(M) WP_063856112.1 pubmed_reference: -> 9372426 tet(M) WP_063856114.1 pubmed_reference: -> 11524166 tet(W) WP_063856415.1 pubmed_reference: -> 15184185 tet(W) WP_063856416.1 pubmed_reference: -> 15184185 tet(Y) WP_063856459.1 pubmed_reference: -> 12957921 vanA WP_063856516.1 pubmed_reference: -> 9687406 vanB WP_063856559.1 pubmed_reference: -> 11376048 vanB WP_063856565.1 pubmed_reference: -> 11376048 vanB WP_063856580.1 pubmed_reference: -> 15616278 vanB WP_063856590.1 pubmed_reference: -> 15616278 vanB WP_063856593.1 pubmed_reference: -> 15616278 vanB WP_063856597.1 pubmed_reference: -> 15616278 vanC WP_063856635.1 pubmed_reference: -> 12615874 vanC WP_063856652.1 pubmed_reference: -> 19216682 vanC WP_063856657.1 pubmed_reference: -> 19216682 vanC WP_063856666.1 pubmed_reference: -> 19216682 vanC WP_063856670.1 pubmed_reference: -> 19216682 vanC WP_063856678.1 pubmed_reference: -> 19216682 vanC WP_063856681.1 pubmed_reference: -> 19216682 vanD WP_063856689.1 pubmed_reference: -> 10479146 vanD WP_063856691.1 pubmed_reference: -> 10835012 vanD WP_063856693.1 pubmed_reference: -> 16495270 vanG WP_063856695.1 pubmed_reference: -> 11036060 vanH-A WP_063856697.1 pubmed_reference: -> 9687406 vanH-Ao1 WP_063856699.1 pubmed_reference: -> 9736537 vanH-D WP_063856702.1 pubmed_reference: -> 10479146 vanH-D WP_063856704.1 pubmed_reference: -> 11083656 vanR-D WP_063856715.1 pubmed_reference: -> 10835012 vanR-A WP_063856716.1 pubmed_reference: -> 9687406 vanR-B WP_063856719.1 pubmed_reference: -> 14617162 vanR-B WP_063856723.1 pubmed_reference: -> 15616278 vanR-C WP_063856725.1 pubmed_reference: -> 19216682 vanS-A WP_063856731.1 pubmed_reference: -> 9687406 vanS-G WP_063856732.1 pubmed_reference: -> 11036060 vanS-C WP_063856733.1 pubmed_reference: -> 10817725 vanT-G WP_063856752.1 pubmed_reference: -> 11036060 vanT-C WP_063856755.1 pubmed_reference: -> 19216682 vanT-C WP_063856756.1 pubmed_reference: -> 19216682 vanTc WP_063856758.1 pubmed_reference: -> 12234834 vanTc WP_063856759.1 pubmed_reference: -> 12615874 vanW-G WP_063856762.1 pubmed_reference: -> 14617152 vanX-A WP_063856767.1 pubmed_reference: -> 9687406 vanX-Ao1 WP_063856769.1 pubmed_reference: -> 9736537 vanX-B WP_063856771.1 pubmed_reference: -> 14617162 vanX-D WP_063856773.1 pubmed_reference: -> 10835012 vanX-D WP_063856774.1 pubmed_reference: -> 15308604 vanX-D WP_063856775.1 pubmed_reference: -> 16495270 vanXY-C WP_063856788.1 pubmed_reference: -> 12234834 vanXY-C WP_063856795.1 pubmed_reference: -> 19216682 vanXY-C WP_063856799.1 pubmed_reference: -> 19216682 vanXY-C WP_063856805.1 pubmed_reference: -> 19216682 vanY-A WP_063856841.1 pubmed_reference: -> 9687406 vanY-D WP_063856862.1 pubmed_reference: -> 10835012 vanY-G WP_063856894.1 pubmed_reference: -> 11036060 vanZ-A WP_063856925.1 pubmed_reference: -> 9687406 vat(E) WP_063856929.1 pubmed_reference: -> 11269234 vat(E) WP_063856930.1 pubmed_reference: -> 11557494 vat(E) WP_063856931.1 pubmed_reference: -> 11557494 vat(E) WP_063856932.1 pubmed_reference: -> 11557494 vat(E) WP_063856933.1 pubmed_reference: -> 11557494 vat(E) WP_063856934.1 pubmed_reference: -> 11557494 vga(A) WP_063856936.1 pubmed_reference: -> 10952567 aadA2 WP_071846222.1 pubmed_reference: -> 11055933 aadA1 WP_071846223.1 pubmed_reference: -> 11055933 ant(2'')-Ia WP_071846238.1 pubmed_reference: -> 19719593 tet(O/W) WP_204313008.1 pubmed_reference: -> 15184185 aac(6')-Ii WP_008265821.1 pubmed_reference: -> 8239603 ampC_Asob-1 WP_063840463.1 allele: -> ampC_Asob-1 hierarchy_node: blaCMY-FOX -> ampC_Asob-1 product_name: FOX/MOX family class C beta-lactamase -> FOX/MOX family cephalosporin-hydrolyzing class C beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN ampC_Sliq-1 WP_063840466.1 allele: -> ampC_Sliq-1 hierarchy_node: bla-C -> ampC_Sliq-1 product_name: class C beta-lactamase -> cephalosporin-hydrolyzing class C beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaACC-1a WP_039189232.1 pubmed_reference: -> 10817695 blaACC-1b WP_063857697.1 pubmed_reference: -> 10817695 blaACC-1c WP_063857698.1 pubmed_reference: -> 10817695 blaACC-1d WP_008815550.1 pubmed_reference: -> 10817695 blaALG11-1 WP_122630833.1 pubmed_reference: -> 28082950 blaALG6-1 WP_122630832.1 pubmed_reference: -> 28082950 blaB-1 WP_029729112.1 pubmed_reference: -> 10817691 blaB-2 WP_063857826.1 pubmed_reference: -> 10817691 blaB-3 WP_063857827.1 pubmed_reference: -> 10817691 blaB-5 WP_063857828.1 pubmed_reference: -> 10858348 blaCRD3-1 WP_122630831.1 pubmed_reference: -> 28082950 blaDHT2-1 WP_122630829.1 pubmed_reference: -> 28082950 blaGRD23-1 WP_122630835.1 pubmed_reference: -> 28082950 blaGRD33-1 WP_122630834.1 pubmed_reference: -> 28082950 blaKLUC-1 WP_061284984.1 pubmed_reference: -> 11709346 blaKPC-104 WP_231869651.1 pubmed_reference: -> 35980232 blaKPC-106 WP_231869655.1 pubmed_reference: -> 35980232 blaKPC-107 WP_231869652.1 pubmed_reference: -> 35980232 blaKPC-108 WP_231869654.1 pubmed_reference: -> 35980232 blaKPC-114 WP_242934069.1 pubmed_reference: -> 35980188 blaKPC-123 WP_242934078.1 pubmed_reference: -> 35794918 blaKPC-157 WP_259115967.1 genbank_nucleotide_accession: JAPQEX010000069.1 -> JAPQEX020000004.1 genbank_protein_accession: MCY6378833.1 -> MDG1646356.1 genbank_start: 2109 -> 57057 genbank_stop: 2990 -> 57938 blaKPC-25 WP_065419571.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-25 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-25 pubmed_reference: 34290688 -> 28223379,34290688 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-26 WP_068981634.1 pubmed_reference: -> 28971868 blaKPC-44 WP_140423311.1 pubmed_reference: -> 31088601 blaKPC-48 WP_213994589.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-48 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-48 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-76 WP_194293135.1 product_name: class A beta-lactamase KPC-76 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-76 pubmed_reference: 34935416 -> 34935416,35588280 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-84 WP_213994590.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-84 -> inhibitor-resistant extended-spectrum carbapenem-hydrolyzing class A beta-lactamase KPC-84 pubmed_reference: -> 26100712,35980232 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-92 WP_240067725.1 pubmed_reference: -> 35107303 blaKPC-96 WP_231869639.1 pubmed_reference: -> 35980232 blaKPC-98 WP_231869634.1 pubmed_reference: -> 35980232 blaLAT-3 WP_032489027.1 pubmed_reference: -> 9231418 blaMOX-18 WP_268871858.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-18 -> class C beta-lactamase MOX-18 blaMOX-19 WP_268871859.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-19 -> class C beta-lactamase MOX-19 blaMOX-20 WP_268871860.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-20 -> class C beta-lactamase MOX-20 blaMOX-21 WP_268871861.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-21 -> class C beta-lactamase MOX-21 blaMOX-22 WP_223915751.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-22 -> class C beta-lactamase MOX-22 blaMOX-23 WP_180898621.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-23 -> class C beta-lactamase MOX-23 blaMOX-24 WP_244054059.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-24 -> class C beta-lactamase MOX-24 blaMOX-25 WP_128343957.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-25 -> class C beta-lactamase MOX-25 blaNDM-20 WP_109545049.1 pubmed_reference: -> 29515538 blaNDM-29 WP_156404656.1 pubmed_reference: -> 34207702,34659178 blaNPS-1 WP_011013281.1 pubmed_reference: -> 11557499 blaORN-2 WP_063860932.1 pubmed_reference: -> 18694786 blaORN-3 WP_063860933.1 pubmed_reference: -> 18694786 blaORN-4 WP_063860934.1 pubmed_reference: -> 18694786 blaORN-5 WP_063860935.1 pubmed_reference: -> 18694786 blaORN-6 WP_063860936.1 pubmed_reference: -> 18694786 blaOXA-1001 WP_042088348.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1041 WP_231869649.1 product_name: OXA-427 family class D beta-lactamase OXA-1041 -> OXA-427 family carbapenem-hydrolyzing class D beta-lactamase OXA-1041 pubmed_reference: -> 36995982 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1052 WP_256875607.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1144 WP_046759755.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-395 WP_015649877.1 pubmed_reference: -> 15155197 blaOXA-396 WP_016852290.1 pubmed_reference: -> 15155197 blaOXA-488 WP_003097028.1 pubmed_reference: -> 15155197 blaOXA-895 WP_100886243.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-930 WP_151781119.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-931 WP_190259776.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-952 WP_213994598.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-953 WP_049044515.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-983 WP_231869608.1 subclass: BETA-LACTAM -> CARBAPENEM blaPDC-166 WP_065102306.1 product_name: class C beta-lactamase PDC-166 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-166 pubmed_reference: -> 26248364 blaPDC-186 WP_087587956.1 product_name: class C beta-lactamase PDC-186 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-186 pubmed_reference: -> 26248364 blaPDC-221 WP_100931731.1 pubmed_reference: 29149337,34930034 -> 26248364,29149337,34930034 blaPDC-222 WP_100931732.1 pubmed_reference: 29149337 -> 29149337,32660987 blaPDC-224 WP_101244936.1 product_name: class C beta-lactamase PDC-224 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-224 pubmed_reference: -> 26248364 blaPDC-228 WP_104009857.1 product_name: class C beta-lactamase PDC-228 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-228 pubmed_reference: -> 26248364,32660987 blaPDC-243 WP_104009840.1 product_name: class C beta-lactamase PDC-243 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-243 pubmed_reference: -> 32660987 blaPDC-245 WP_100831609.1 pubmed_reference: 31636072 -> 31636072,32660987 blaPDC-267 WP_109791201.1 product_name: class C beta-lactamase PDC-267 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-267 pubmed_reference: -> 26248364 blaPDC-270 WP_109791203.1 pubmed_reference: 31636072 -> 31636072,32660987 blaPDC-300 WP_111672889.1 product_name: class C beta-lactamase PDC-300 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-300 pubmed_reference: -> 26248364 blaPDC-306 WP_116786838.1 product_name: class C beta-lactamase PDC-306 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-306 pubmed_reference: -> 26248364 blaPDC-309 WP_122630847.1 product_name: class C beta-lactamase PDC-309 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-309 pubmed_reference: -> 26248364 blaPDC-321 WP_150823480.1 product_name: class C beta-lactamase PDC-321 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-321 pubmed_reference: -> 26248364 blaPDC-322 WP_138403314.1 pubmed_reference: 31636072 -> 31636072,32660987 blaPDC-325 WP_150823483.1 pubmed_reference: -> 26248364 blaPDC-327 WP_150823485.1 product_name: class C beta-lactamase PDC-327 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-327 pubmed_reference: -> 26248364 blaPDC-329 WP_150823487.1 product_name: class C beta-lactamase PDC-329 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-329 pubmed_reference: -> 26248364 blaPDC-334 WP_148044426.1 product_name: class C beta-lactamase PDC-334 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-334 pubmed_reference: -> 32660987 blaPDC-336 WP_148044428.1 product_name: class C beta-lactamase PDC-336 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-336 pubmed_reference: -> 26248364 blaPDC-337 WP_148044429.1 product_name: class C beta-lactamase PDC-337 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-337 pubmed_reference: -> 26248364 blaPDC-340 WP_148044432.1 product_name: class C beta-lactamase PDC-340 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-340 pubmed_reference: -> 26248364 blaPDC-345 WP_148044437.1 product_name: class C beta-lactamase PDC-345 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-345 pubmed_reference: -> 26248364 blaPDC-346 WP_148044438.1 pubmed_reference: 31636072 -> 31636072,32660987 blaPDC-373 WP_148044460.1 product_name: class C beta-lactamase PDC-373 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-373 pubmed_reference: -> 26248364,32660987 blaPDC-381 WP_148044467.1 pubmed_reference: 31636072 -> 31636072,32660987 blaPDC-382 WP_148044468.1 product_name: class C beta-lactamase PDC-382 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-382 pubmed_reference: -> 32660987 blaPDC-387 WP_152315506.1 product_name: class C beta-lactamase PDC-387 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-387 pubmed_reference: -> 32660987 blaPDC-391 WP_164461295.1 product_name: class C beta-lactamase PDC-391 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-391 pubmed_reference: -> 32660987 blaPDC-394 WP_164461298.1 product_name: class C beta-lactamase PDC-394 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-394 pubmed_reference: -> 26248364 blaPDC-399 WP_168247886.1 product_name: class C beta-lactamase PDC-399 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-399 pubmed_reference: -> 26248364 blaPDC-405 WP_168247891.1 product_name: class C beta-lactamase PDC-405 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-405 pubmed_reference: -> 26248364 blaPDC-409 WP_168247893.1 product_name: class C beta-lactamase PDC-409 -> inhibitor-resistant class C beta-lactamase PDC-409 pubmed_reference: -> 32660987 blaPDC-411 WP_168247895.1 product_name: class C beta-lactamase PDC-411 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-411 pubmed_reference: -> 26248364 blaPDC-419 WP_168247903.1 product_name: class C beta-lactamase PDC-419 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-419 pubmed_reference: -> 26248364 blaPDC-422 WP_179284354.1 product_name: class C beta-lactamase PDC-422 -> inhibitor-resistant class C beta-lactamase PDC-422 pubmed_reference: -> 32660987 blaPDC-423 WP_134600670.1 pubmed_reference: 31636072 -> 31636072,32660987 blaPDC-446 WP_179284383.1 product_name: class C beta-lactamase PDC-446 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-446 pubmed_reference: -> 26248364 blaPDC-448 WP_179284385.1 product_name: class C beta-lactamase PDC-448 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-448 pubmed_reference: -> 26248364,32660987 blaPDC-468 WP_204376241.1 pubmed_reference: 31636072 -> 31636072,32660987 blaPDC-469 WP_204376242.1 product_name: class C beta-lactamase PDC-469 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-469 pubmed_reference: -> 26248364 blaPDC-472 WP_204376245.1 product_name: class C beta-lactamase PDC-472 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-472 pubmed_reference: -> 26248364 blaPDC-475 WP_204378710.1 product_name: class C beta-lactamase PDC-475 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-475 pubmed_reference: -> 32660987 blaPDC-479 WP_213994607.1 product_name: class C beta-lactamase PDC-479 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-479 pubmed_reference: -> 26248364 blaPDC-480 WP_213994608.1 product_name: class C beta-lactamase PDC-480 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-480 pubmed_reference: -> 26248364,32660987 blaPDC-481 WP_213994609.1 product_name: class C beta-lactamase PDC-481 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-481 pubmed_reference: -> 26248364 blaPDC-482 WP_213994610.1 product_name: inhibitor-resistant class C beta-lactamase PDC-482 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-482 pubmed_reference: 34930034 -> 26248364,34930034 blaPDC-483 WP_213994611.1 pubmed_reference: 34930034 -> 32660987,34930034 blaPDC-487 WP_219860724.1 product_name: class C beta-lactamase PDC-487 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-487 pubmed_reference: -> 26248364 blaPDC-497 WP_231869635.1 product_name: class C beta-lactamase PDC-497 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-497 pubmed_reference: -> 26248364 blaPDC-500 WP_231873784.1 pubmed_reference: 31636072 -> 31636072,32660987 blaPDC-510 WP_240067745.1 pubmed_reference: 31636072 -> 31636072,32660987 blaPDC-515 WP_242934123.1 product_name: class C beta-lactamase PDC-515 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-515 pubmed_reference: -> 26248364 blaPDC-531 WP_262697184.1 product_name: class C beta-lactamase PDC-531 -> inhibitor-resistant class C beta-lactamase PDC-531 pubmed_reference: -> 32660987 blaPDC-537 WP_243210688.1 product_name: class C beta-lactamase PDC-537 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-537 pubmed_reference: -> 26248364 blaPDC-74 WP_040184286.1 product_name: extended-spectrum class C beta-lactamase PDC-74 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-74 blaPDC-86 WP_058198950.1 product_name: extended-spectrum class C beta-lactamase PDC-86 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-86 blaPEN-B2 WP_262697188.1 pubmed_reference: -> 19075063 blaPEN-B3 WP_262697189.1 pubmed_reference: -> 19075063 blaPEN-B4 WP_163122236.1 pubmed_reference: -> 19075063 blaPLA-3 WP_032696109.1 pubmed_reference: -> 18694786 blaPLA-4 WP_032687534.1 pubmed_reference: -> 18694786 blaRAD-1 WP_004919358.1 pubmed_reference: -> 36883515 blaRAHN-1 WP_063864600.1 pubmed_reference: -> 11557504 blaRATA-1 WP_064964607.1 genbank_nucleotide_accession: LUDJ01000009.1 -> CP121209.1 genbank_protein_accession: OBP43755.1 -> WFS34552.1 genbank_start: 257 -> 1982453 genbank_stop: 1171 -> 1983367 genbank_strand: - -> + blaROB-1 WP_005618523.1 pubmed_reference: -> 2201253 blaSFC-1 WP_024531321.1 pubmed_reference: -> 15155245 blaSPN79-1 WP_122630830.1 pubmed_reference: -> 28082950 blaVEB-9 WP_032494864.1 pubmed_reference: -> 11384532 blaVHH-1 WP_063865164.1 pubmed_reference: -> 10770767 blaVHW-1 WP_063865165.1 pubmed_reference: -> 10770767 cfiA10 WP_063865205.1 pubmed_reference: -> 12604530 cfiA2 WP_015083750.1 pubmed_reference: -> 12604530 cfiA4 WP_005821510.1 pubmed_reference: -> 12604530 cfiA8 WP_063865206.1 pubmed_reference: -> 12604530 cfiA9 WP_063865207.1 pubmed_reference: -> 12604530 cphA2 WP_063865208.1 pubmed_reference: -> 1856163 dfrA13 WP_063844334.1 pubmed_reference: -> 10639362 fosA WP_038415208.1 pubmed_reference: -> 1963292 gyrA_D87G WP_001281243.1 pubmed_reference: -> 9756773 gyrA_T83I WP_003091448.1 pubmed_reference: 8540700 -> 8540700,33875431 lnu(A)' WP_011428879.1 pubmed_reference: -> 17329268 oprD_Q142STOP WP_003112576.1 pubmed_reference: 27736752 -> 27736752,29681898 rmtE1 WP_063866478.1 product_name: 16S rRNA (guanine(1405)-N(7))-methyltransferase RmtE -> 16S rRNA (guanine(1405)-N(7))-methyltransferase RmtE1 vanS-B-Delta WP_063856737.1 pubmed_reference: -> 14617162 Hierarchy nodes added core AMR AMR ampC_Ecan ampC CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase ampC_Kaer ampC NF041662.1 CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase ampC_Sliq ampC NF041663.1 cephalosporin-hydrolyzing class C beta-lactamase blaCAE blaCAE NF041590.1 CAE family broad-spectrum class A beta-lactamase Changed Hierarchy Nodes aacA57-2 aminoglycoside N-acetyltransferase AAC(6')-Ian subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN blaKHM KHM family subclass B1 metallo-beta-lactamase hmm_acc: -> NF041632.1 ---------------------------------------------------------------------- Changes included in 2023-02-23.1 ---------------------------------------------------------------------- Overview: - To conform with Oswaldi et al., 2022 PMID:35336088 and https://faculty.washington.edu/marilynr/ we have changed the gene symbol for CAC98997.1 from lin to vga(G) - The non-core protein previously designated nirA is now recognized to have represented a truncated sequence otherwise equivalent to ncrA. The node called nirA has been retired. - Review of the literature for many beta-lactamases led to improved subclass designations and/or product names for many cephalosporinases and carbapenemases - Continuing curation led to the addition of many pubmed citations - Several proteins were removed/replaced becuase they were incorrectly extended versions - Includes new alleles submitted to NCBI for nomenclature assignment - New genes and point mutations identified by our curators in the literature including multiple point mutations for Neisseria gonorrhoeae Summary: Total proteins: 7627 Core proteins: 6536 Plus proteins: 1090 AMR proteins: 6584 STRESS proteins: 235 VIRULENCE proteins: 808 PubMed references: 2912 Point mutations: 1013 Point mutation reference sequences: 177 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Clostridioides_difficile, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 688 Updates since release 2022-12-19.1: Proteins added: 39 Core proteins added: 39 Plus proteins added: 0 AMR proteins added: 39 Alleles added: 27 PubMed references added: 294 PubMed references removed: 1 Point mutations added: 10 Proteins removed: 9 Core proteins removed: 2 Plus proteins removed: 7 Reference Gene Catalog entries changed: 303 Hierarchy nodes added: 13 Hierarchy nodes removed: 3 Hierarchy nodes changed: 8 Added proteins core AMR AMR almF NG_149645.1 WP_000806242.1 lipid A modification system glycine carrier protein AlmF almG NG_149646.1 WP_001881365.1 glycine--lipid A transferase AlmG vanS-I NG_149654.1 WP_011461302.1 VanI-type vancomycin resistance histidine kinase VanS fosXCC NG_149649.1 WP_024725385.1 fosfomycin resistance hydrolase FosXCC thfT NG_149653.1 WP_048327435.1 reduced folate ECF transporter S component ThfT aph(2'')-Ii NG_149647.1 WP_052776520.1 aminoglycoside O-phosphotransferase APH(2'')-Ii lnu(E) NG_149650.1 WP_063851343.1 lincosamide nucleotidyltransferase Lnu(E) sal(D) NG_149651.1 WP_082039181.1 ABC-F type ribosomal protection protein Sal(D) sal(E) NG_149652.1 WP_096809342.1 ABC-F type ribosomal protection protein Sal(E) vga(F) NG_149655.1 WP_171943877.1 ABC-F type ribosomal protection protein Vga(F) almE NG_149644.1 WP_252944138.1 lipid A modification system glycine--protein ligase AlmE aph(2'')-Ii NG_149648.1 WP_274293081.1 aminoglycoside O-phosphotransferase APH(2'')-Ii blaADC-291 NG_149679.1 WP_001211201.1 extended-spectrum class C beta-lactamase ADC-291 blaB-37 NG_149656.1 WP_078798391.1 subclass B1 metallo-beta-lactamase BlaB-37 blaCMY-185 NG_149657.1 WP_274293082.1 class C beta-lactamase CMY-185 blaCTX-M-152 NG_048938.1 WP_064543755.1 extended-spectrum class A beta-lactamase CTX-M-152 blaIND-17 NG_149680.1 WP_274375789.1 subclass B1 metallo-beta-lactamase IND-17 blaIND-18 NG_149681.1 WP_274375790.1 subclass B1 metallo-beta-lactamase IND-18 blaKPC-109 NG_149659.1 WP_274293083.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-109 blaKPC-155 NG_149660.1 WP_274293084.1 inhibitor-resistant class A beta-lactamase KPC-155 blaKPC-156 NG_149661.1 WP_274293085.1 carbapenem-hydrolyzing class A beta-lactamase KPC-156 blaKPC-157 NG_149662.1 WP_259115967.1 carbapenem-hydrolyzing class A beta-lactamase KPC-157 blaNDM-49 NG_149663.1 WP_274293086.1 subclass B1 metallo-beta-lactamase NDM-49 blaNDM-50 NG_149664.1 WP_274293087.1 subclass B1 metallo-beta-lactamase NDM-50 blaOXA-1181 NG_149665.1 WP_274293088.1 OXA-48 family class D beta-lactamase OXA-1181 blaOXA-1182 NG_149666.1 WP_274293089.1 OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-1182 blaOXA-1185 NG_149667.1 WP_274293090.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1185 blaPDC-538 NG_149668.1 WP_274293091.1 class C beta-lactamase PDC-538 blaPDC-539 NG_149669.1 WP_274293092.1 class C beta-lactamase PDC-539 blaPDC-540 NG_149682.1 WP_274375791.1 class C beta-lactamase PDC-540 blaPDC-541 NG_149683.1 WP_274375792.1 class C beta-lactamase PDC-541 blaPDC-542 NG_149684.1 WP_274375793.1 class C beta-lactamase PDC-542 blaPJM-2 NG_149670.1 WP_162338672.1 subclass B3 metallo-beta-lactamase PJM-2 blaRATA-1 NG_149671.1 WP_064964607.1 extended-spectrum class A beta-lactamase RATA-1 blaRATA-2 NG_149672.1 WP_154469535.1 extended-spectrum class A beta-lactamase RATA-2 blaVIM-86 NG_149673.1 WP_274293093.1 subclass B1 metallo-beta-lactamase VIM-86 cfiA29 NG_149674.1 WP_250718547.1 subclass B1 metallo-beta-lactamase CfiA29 cfiA30 NG_149675.1 WP_234164690.1 subclass B1 metallo-beta-lactamase CfiA30 cfiA31 NG_149676.1 WP_186993003.1 subclass B1 metallo-beta-lactamase CfiA31 Added point mutations core AMR POINT ftsI_A498T CEPHALOSPORIN Escherichia glpT_A434V FOSFOMYCIN Staphylococcus_aureus mtrR_G45S AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria_gonorrhoeae parC_D86G QUINOLONE Neisseria_gonorrhoeae parC_E91A QUINOLONE Neisseria_gonorrhoeae parC_E91Q QUINOLONE Neisseria_gonorrhoeae parC_S87C QUINOLONE Neisseria_gonorrhoeae porB1b_A121S CEPHALOSPORIN/QUINOLONE/TETRACYCLINE Neisseria_gonorrhoeae rpoB_H553N RIFAMPIN Neisseria_gonorrhoeae rpoB_L560S RIFAMPIN Neisseria_gonorrhoeae Removed proteins core AMR AMR aph(3'')-Ib NG_056002.2 WP_109545041.1 aminoglycoside O-phosphotransferase APH(3'')-Ib blaCTX-M-152 NG_048938.1 WP_063859961.1 extended-spectrum class A beta-lactamase CTX-M-152 plus AMR AMR almG AE003852.1 AAF94731.1 glycine--lipid A transferase AlmG plus STRESS METAL nirA AY492000.1 AAR82963.1 nickel resistance membrane nickel efflux protein NirA plus VIRULENCE VIRULENCE iss AE014075.1 AAN80033.1 increased serum survival lipoprotein Iss iss CP000468.1 ABJ00546.1 increased serum survival lipoprotein Iss iss CU928158.2 CAQ90194.1 increased serum survival lipoprotein Iss iss CU928160.2 CAQ97644.1 increased serum survival lipoprotein Iss iroN FP929040.1 CBK85583.1 siderophore salmochelin receptor IroN Changed reference gene catalog records catB3 WP_000186237.1 pubmed_reference: -> 7793874 armA WP_000359986.1 pubmed_reference: -> 16626740 aph(6)-Id WP_000480968.1 pubmed_reference: -> 2653965 dfrA8 WP_000571065.1 pubmed_reference: -> 7867952 tet(S) WP_000691722.1 pubmed_reference: -> 8370538 tet(M) WP_000691746.1 pubmed_reference: -> 16565159 tet(M) WP_000691749.1 pubmed_reference: -> 1323953 fosB WP_000943772.1 hierarchy_node: fosB_gen -> fosBx1-fam product_name: FosB/FosD family fosfomycin resistance bacillithiol transferase -> FosBx1 family fosfomycin resistance bacillithiol transferase erm(C) WP_001003263.1 pubmed_reference: -> 3087948 erm(C) WP_001003264.1 pubmed_reference: -> 3141573 aac(6')-Ie/aph(2'')-Ia WP_001028144.1 pubmed_reference: -> 2833561 vanR-A WP_001280781.1 pubmed_reference: -> 7867956,8380148 blaI WP_001284656.1 pubmed_reference: -> 1861992 tet(M) WP_001574275.1 pubmed_reference: -> 16565159 tet(L) WP_001574277.1 pubmed_reference: -> 2438417 vanY-A WP_001812592.1 pubmed_reference: -> 7867956,8380148 vat(D) WP_002295712.1 pubmed_reference: -> 8257133 vanS-A WP_002305818.1 pubmed_reference: -> 7867956,8380148 vanW-B WP_002368694.1 pubmed_reference: -> 8631706 vanY-B WP_002368695.1 pubmed_reference: -> 8631706 vanS-B WP_002368696.1 pubmed_reference: -> 8631706 vanR-B WP_002368697.1 pubmed_reference: -> 8631706 tet(M) WP_002414694.1 pubmed_reference: -> 16565159 erm(F) WP_002682030.1 pubmed_reference: -> 2820936 tet(O) WP_002779752.1 pubmed_reference: -> 2836268 aadE-Cc WP_002785795.1 hierarchy_node: aadE-Cc -> ant(6)-Ig product_name: aminoglycoside 6-adenylyltransferase AadE-Cc -> aminoglycoside nucleotidyltransferase ANT(6)-Ig erm(D) WP_003183781.1 pubmed_reference: -> 1713206 aadK WP_003229862.1 pubmed_reference: -> 2550327 erm(O) WP_003972831.1 pubmed_reference: -> 1761231 cfxA3 WP_004348227.1 subclass: BETA-LACTAM -> CEPHALOSPORIN aph(3'')-Ib WP_010890156.1 pubmed_reference: -> 2653965 vga(G) WP_010989615.1 gene_family: lin -> vga(G) hierarchy_node: lin -> vga(G) product_name: lmo0919 family lincomycin resistance ABC-F type ribosomal protection protein -> ABC-F type ribosomal protection protein Vga(G) cepA WP_010992371.1 pubmed_reference: -> 7517394 blaE WP_011729443.1 pubmed_reference: -> 15699201 tetA(P) WP_012478244.1 pubmed_reference: -> 8170402 erm(G) WP_014387027.1 pubmed_reference: -> 3025178 vanR-D WP_023042613.1 pubmed_reference: -> 10368136 vanX-D WP_023042861.1 pubmed_reference: -> 10368136 erm(D) WP_025811090.1 pubmed_reference: -> 6429477 vanC WP_029487031.1 pubmed_reference: -> 1551598,10817725 cmlA1 WP_032488514.1 pubmed_reference: -> 1648560 catB3 WP_032489305.1 pubmed_reference: -> 7793874,9835490 aadD1 WP_032542910.1 pubmed_reference: -> 6090428 cfxA5 WP_032946415.1 subclass: BETA-LACTAM -> CEPHALOSPORIN aac(3)-IIb WP_033147097.1 pubmed_reference: -> 1444303 tet(O) WP_044666383.1 pubmed_reference: -> 2841293 blaL1 WP_046430859.1 pubmed_reference: -> 19146537 tcmA WP_052413892.1 pubmed_reference: -> 1592819 cfxA4 WP_057280848.1 subclass: BETA-LACTAM -> CEPHALOSPORIN aac(3)-IId WP_063840265.1 pubmed_reference: -> 8117265 aac(3)-VIa WP_063840273.1 pubmed_reference: -> 8257126 ampC WP_063840463.1 pubmed_reference: -> 7811022 ant(4')-IIa WP_063840508.1 pubmed_reference: -> 8494365 ant(9)-Ib WP_063840673.1 pubmed_reference: -> 1659306 aph(3'')-Ia WP_063840677.1 pubmed_reference: -> 2844130 blaL1 WP_063842690.1 pubmed_reference: -> 19146537 blaL1 WP_063842691.1 pubmed_reference: -> 19146537 blaL1 WP_063842692.1 pubmed_reference: -> 19146537 blaL1 WP_063842693.1 pubmed_reference: -> 19146537 blaL1 WP_063842694.1 pubmed_reference: -> 19146537 blaL1 WP_063842696.1 pubmed_reference: -> 19146537 blaL1 WP_063842697.1 pubmed_reference: -> 19146537 blaL1 WP_063842698.1 pubmed_reference: -> 19146537 blaL2 WP_063842700.1 product_name: L2 family class A beta-lactamase -> L2 family extended-spectrum class A beta-lactamase pubmed_reference: -> 18212097 subclass: BETA-LACTAM -> CEPHALOSPORIN catA WP_063843210.1 pubmed_reference: -> 1929326 erm(B) WP_063844614.1 pubmed_reference: -> 6406429 erm(B) WP_063844619.1 pubmed_reference: -> 2832378 erm(C) WP_063844768.1 pubmed_reference: -> 2822666 erm(E) WP_063844770.1 pubmed_reference: -> 2998943,3934045 erm(F) WP_063844771.1 pubmed_reference: -> 1905805 erm(S) WP_063844819.1 pubmed_reference: -> 3127381 floR WP_063844973.1 pubmed_reference: -> 10103189 grm WP_063851283.1 pubmed_reference: -> 2013410 mgt WP_063853740.1 pubmed_reference: -> 1761231 otr(A) WP_063854498.1 pubmed_reference: -> 1510403 tet(L) WP_063856080.1 pubmed_reference: -> 2996983 tet(M) WP_063856108.1 pubmed_reference: -> 2073121 tet(M) WP_063856110.1 pubmed_reference: -> 3344217 tet(M) WP_063856395.1 pubmed_reference: -> 16565159 tet(M) WP_063856396.1 pubmed_reference: -> 16565159 tet(Q) WP_063856407.1 pubmed_reference: -> 7944364 vanC WP_063856645.1 pubmed_reference: -> 16495270 vanD WP_063856690.1 pubmed_reference: -> 10368136 vanH-D WP_063856703.1 pubmed_reference: -> 10368136 vanH-D WP_063856705.1 pubmed_reference: -> 16495270 vanH-Pt WP_063856708.1 pubmed_reference: -> 16189102 vanH WP_063856709.1 pubmed_reference: -> 16189102 vanR-A WP_063856720.1 pubmed_reference: -> 16189102 vanR-A WP_063856721.1 pubmed_reference: -> 16189102 vanR-D WP_063856722.1 pubmed_reference: -> 16495270 vanS-D WP_063856730.1 pubmed_reference: -> 10368136 vanS-Pt WP_063856741.1 pubmed_reference: -> 16189102 vanS-Pt WP_063856742.1 pubmed_reference: -> 16189102 vanS-C WP_063856743.1 pubmed_reference: -> 16495270 vanS-D WP_063856744.1 pubmed_reference: -> 16495270 vanT-C WP_063856754.1 pubmed_reference: -> 16495270 vanW-Pt WP_063856764.1 pubmed_reference: -> 16189102 vanX-B WP_063856770.1 pubmed_reference: -> 8631706 vanX-Pt WP_063856780.1 pubmed_reference: -> 16189102 vanX-Pt WP_063856781.1 pubmed_reference: -> 16189102 vanY-D WP_063856854.1 pubmed_reference: -> 10368136 vanY-D WP_063856871.1 pubmed_reference: -> 16495270 vanY-Pt WP_063856910.1 pubmed_reference: -> 16189102 vanY-Pt WP_063856916.1 pubmed_reference: -> 16189102 vanZ-Pt WP_063856927.1 pubmed_reference: -> 16189102 vgb(A) WP_063856939.1 pubmed_reference: -> 3149758 aadA2 WP_071846218.1 pubmed_reference: -> 10103189 vanH-B WP_099156040.1 pubmed_reference: -> 8631706 blaRSA1 WP_216944871.1 pubmed_reference: -> 29316517 aac(6')-Ig WP_005081764.1 pubmed_reference: -> 8257129 blaACC-1 WP_032491956.1 pubmed_reference: 10428914 -> 10428914,10817695 blaACC-4 WP_063857708.1 pubmed_reference: 17664321 -> 17664321,35435729 blaACI-1 WP_006555379.1 pubmed_reference: -> 11036038 blaACT-89 WP_049134845.1 pubmed_reference: -> 11179650 blaADC-1 WP_004714775.1 pubmed_reference: 10639377 -> 10639377,24598745 blaADC-11 WP_001211205.1 pubmed_reference: -> 20547808 blaADC-30 WP_001211218.1 pubmed_reference: -> 21788456 blaADC-33 WP_001211220.1 pubmed_reference: -> 20547808 blaADC-5 WP_038405930.1 pubmed_reference: 15047547 -> 15047547,24845871 blaADC-51 WP_063857805.1 pubmed_reference: -> 20713667 blaADC-53 WP_063857806.1 pubmed_reference: -> 20713667 blaAQU-1 WP_042888870.1 product_name: class C beta-lactamase AQU-1 -> extended-spectrum class C beta-lactamase AQU-1 pubmed_reference: -> 24055254 subclass: BETA-LACTAM -> CEPHALOSPORIN blaASU1-1 WP_219860711.1 pubmed_reference: -> 36626997 subclass: BETA-LACTAM -> CEPHALOSPORIN synonyms: -> blaSSA blaB3SU1-1 WP_219860712.1 pubmed_reference: -> 36626997 subclass: BETA-LACTAM -> CEPHALOSPORIN synonyms: -> blaSSB1 blaB3SU2-1 WP_219860713.1 pubmed_reference: -> 36626997 subclass: BETA-LACTAM -> CEPHALOSPORIN synonyms: -> blaSSB2 blaBES-1 WP_015060700.1 product_name: class A extended spectrum beta-lactamase BES-1 -> extended spectrum class A beta-lactamase BES-1 blaBPU-1 WP_041816295.1 pubmed_reference: -> 26551395 subclass: BETA-LACTAM -> CEPHALOSPORIN blaBUT-1 WP_104531863.1 product_name: class C beta-lactamase BUT-1 -> extended-spectrum class C beta-lactamase BUT-1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaCARB-24 WP_031413517.1 pubmed_reference: -> 25801555 blaCARB-25 WP_042771632.1 pubmed_reference: -> 25801555 blaCARB-26 WP_029795186.1 pubmed_reference: -> 25801555 blaCARB-27 WP_025623492.1 pubmed_reference: -> 25801555 blaCARB-28 WP_029839920.1 pubmed_reference: -> 25801555 blaCARB-29 WP_029834158.1 pubmed_reference: -> 25801555 blaCARB-30 WP_005498292.1 pubmed_reference: -> 25801555 blaCARB-31 WP_025546314.1 pubmed_reference: -> 25801555 blaCARB-32 WP_029837067.1 pubmed_reference: -> 25801555 blaCARB-33 WP_025535332.1 pubmed_reference: -> 25801555 blaCARB-34 WP_029815111.1 pubmed_reference: -> 25801555 blaCARB-35 WP_025521699.1 pubmed_reference: -> 25801555 blaCARB-36 WP_025525762.1 pubmed_reference: -> 25801555 blaCARB-38 WP_025551322.1 pubmed_reference: -> 25801555 blaCARB-40 WP_025816575.1 pubmed_reference: -> 25801555 blaCARB-41 WP_025788060.1 pubmed_reference: -> 25801555 blaCARB-42 WP_005375420.1 pubmed_reference: -> 25801555 blaCARB-43 WP_025794721.1 pubmed_reference: -> 25801555 blaCDD-1 WP_009901927.1 product_name: class D beta-lactamase CDD-1 -> extended-spectrum class D beta-lactamase CDD-1 pubmed_reference: -> 30563905,34427801 subclass: BETA-LACTAM -> CEPHALOSPORIN blaCDD-2 WP_021361759.1 product_name: class D beta-lactamase CDD-2 -> extended-spectrum class D beta-lactamase CDD-2 pubmed_reference: -> 30563905,34427801 subclass: BETA-LACTAM -> CEPHALOSPORIN blaCME-2 WP_063859570.1 pubmed_reference: -> 10602714 blaCMH-1 WP_063859580.1 product_name: class C beta-lactamase CMH-1 -> extended-spectrum class C beta-lactamase CMH-1 pubmed_reference: -> 30577544 subclass: BETA-LACTAM -> CEPHALOSPORIN blaCMH-3 WP_045295573.1 pubmed_reference: -> 32130234,34395716 blaCMY-10 WP_032492452.1 product_name: CMY-1/MOX family class C beta-lactamase CMY-10 -> CMY-1/MOX family extended-spectrum class C beta-lactamase CMY-10 pubmed_reference: 12969288 -> 12969288,16677302,17890420 blaCMY-107 WP_032494240.1 product_name: class C beta-lactamase CMY-107 -> extended-spectrum class C beta-lactamase CMY-107 blaCMY-136 WP_164924988.1 product_name: class C beta-lactamase CMY-136 -> extended-spectrum class C beta-lactamase CMY-136 blaCMY-172 WP_215824899.1 product_name: inhibitor-resistant class C beta-lactamase CMY-172 -> inhibitor-resistant extended-spectrum class C beta-lactamase CMY-172 blaCMY-19 WP_063859826.1 pubmed_reference: 16436707 -> 16436707,17890420,18227084 blaCMY-27 WP_063859831.1 product_name: class C beta-lactamase CMY-27 -> extended-spectrum class C beta-lactamase CMY-27 blaCMY-32 WP_063859834.1 product_name: class C beta-lactamase CMY-32 -> extended-spectrum class C beta-lactamase CMY-32 blaCMY-33 WP_063859835.1 product_name: class C beta-lactamase CMY-33 -> extended-spectrum class C beta-lactamase CMY-33 pubmed_reference: 19414578 -> 19414578,26392491 blaCMY-42 WP_039023136.1 pubmed_reference: 21388298 -> 21388298,27799202 blaCMY-44 WP_063859842.1 product_name: class C beta-lactamase CMY-44 -> extended-spectrum class C beta-lactamase CMY-44 blaCMY-54 WP_063859848.1 product_name: class C beta-lactamase CMY-54 -> extended-spectrum class C beta-lactamase CMY-54 pubmed_reference: 22956023 -> 22956023,28665771 blaCMY-69 WP_063859861.1 pubmed_reference: -> 24820081 blaCMY-8 WP_012477380.1 pubmed_reference: 10817689 -> 10817689,12121914 blaCMY-9 WP_032490177.1 pubmed_reference: 12121914 -> 12121914,17890420,18227084 blaCMY-95 WP_063859916.1 product_name: class C beta-lactamase CMY-95 -> extended-spectrum class C beta-lactamase CMY-95 blaDES-1 WP_063860095.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaFAR-1 WP_070064531.1 pubmed_reference: -> 10390216 blaFONA-1 WP_046808255.1 pubmed_reference: -> 24211774 blaFONA-2 WP_063860489.1 pubmed_reference: -> 24211774 blaFONA-3 WP_063860490.1 pubmed_reference: -> 24211774 blaFONA-4 WP_063860491.1 pubmed_reference: -> 24211774 blaFONA-5 WP_063860492.1 pubmed_reference: -> 24211774 blaFONA-6 WP_063860493.1 pubmed_reference: -> 24211774 blaFOX-3 WP_033147149.1 pubmed_reference: 9527810 -> 23877692,9527810 blaFOX-4 WP_032489727.1 pubmed_reference: 10952615,31685471 -> 10952615,20382725,31685471 blaFRI-11 WP_223174987.1 pubmed_reference: -> 35137119 blaFTU-1 WP_003023375.1 pubmed_reference: -> 28443249 blaGES-27 WP_063860512.1 pubmed_reference: -> 26638216 blaGOB-18 WP_063860560.1 pubmed_reference: -> 17403673 blaIDC-1 WP_168247881.1 product_name: class C beta-lactamase IDC-1 -> extended-spectrum class C beta-lactamase IDC-1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaIDC-2 WP_168247882.1 product_name: class C beta-lactamase IDC-2 -> extended-spectrum class C beta-lactamase IDC-2 subclass: BETA-LACTAM -> CEPHALOSPORIN blaIMI-22 WP_223174988.1 pubmed_reference: -> 35137119 blaIMI-23 WP_223525081.1 pubmed_reference: -> 35137119 blaIMI-5 WP_085562405.1 pubmed_reference: -> 28223374 blaIMI-6 WP_063860570.1 pubmed_reference: -> 28223374 blaKPC-112 WP_240067722.1 pubmed_reference: -> 36374086 blaKPC-125 WP_248496376.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-125 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-125 pubmed_reference: -> 36112395 blaKPC-133 WP_257102138.1 pubmed_reference: -> 27242772 blaLAQ-1 WP_219860729.1 product_name: class C beta-lactamase LAQ-1 -> extended-spectrum class C beta-lactamase LAQ-1 pubmed_reference: -> 36504772 subclass: BETA-LACTAM -> CEPHALOSPORIN blaLHK-1 WP_081666691.1 pubmed_reference: -> 15855519 blaLHK-2 WP_104531865.1 pubmed_reference: -> 15855519 blaLHK-3 WP_104531866.1 pubmed_reference: -> 15855519 blaLHK-4 WP_104531867.1 pubmed_reference: -> 15855519 blaLHK-5 WP_104531868.1 pubmed_reference: -> 15855519 blaLHK-6 WP_104531869.1 pubmed_reference: -> 15855519 blaLUT-1 WP_010798607.1 pubmed_reference: -> 19884377 blaLUT-2 WP_063860828.1 pubmed_reference: -> 19884377 blaLUT-3 WP_063860829.1 pubmed_reference: -> 19884377 blaLUT-4 WP_063860830.1 pubmed_reference: -> 19884377 blaLUT-5 WP_063860831.1 pubmed_reference: -> 19884377 blaLUT-6 WP_063860832.1 pubmed_reference: -> 19884377 blaMOX-1 WP_032489888.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-1 -> CMY-1/MOX family extended-spectrum class C beta-lactamase MOX-1 pubmed_reference: 8112596 -> 24777102,8112596 blaMOX-13 WP_096807444.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-13 -> CMY-1/MOX family extended-spectrum class C beta-lactamase MOX-13 pubmed_reference: -> 35435729 blaMOX-2 WP_063860845.1 product_name: CMY-1/MOX family class C beta-lactamase MOX-2 -> CMY-1/MOX family extended-spectrum class C beta-lactamase MOX-2 pubmed_reference: 12069985 -> 12069985,35435729 blaOHIO-1 WP_063860895.1 pubmed_reference: -> 2121093,26511485 blaORN-1 WP_004862397.1 pubmed_reference: -> 14693555 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-101 WP_063860937.1 pubmed_reference: -> 26546762 blaOXA-114p WP_076412384.1 pubmed_reference: -> 24038696 blaOXA-114q WP_136512075.1 pubmed_reference: -> 24038696 blaOXA-114r WP_136512076.1 pubmed_reference: -> 24038696 blaOXA-114s WP_136512077.1 pubmed_reference: -> 24038696 blaOXA-114t WP_136512078.1 pubmed_reference: -> 24038696 blaOXA-114u WP_136512079.1 pubmed_reference: -> 24038696 blaOXA-114v WP_136512080.1 pubmed_reference: -> 24038696 blaOXA-13 WP_063861035.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-163 WP_063131934.1 pubmed_reference: 21422200 -> 21422200,35208713 subclass: CEPHALOSPORIN -> CARBAPENEM blaOXA-247 WP_032495595.1 product_name: OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-247 -> OXA-48 family extended-spectrum class D beta-lactamase OXA-247 pubmed_reference: 23402333 -> 23402333,35208713 subclass: CARBAPENEM -> CEPHALOSPORIN blaOXA-322 WP_063862632.1 pubmed_reference: -> 24288029 blaOXA-323 WP_063862638.1 pubmed_reference: -> 24288029 blaOXA-324 WP_063862643.1 pubmed_reference: -> 24288029 blaOXA-325 WP_063862646.1 pubmed_reference: -> 24288029 blaOXA-326 WP_063862651.1 pubmed_reference: -> 24288029 blaOXA-327 WP_063862656.1 pubmed_reference: -> 24288029 blaOXA-328 WP_063862662.1 pubmed_reference: -> 24288029 blaOXA-329 WP_063862667.1 pubmed_reference: -> 24288029 blaOXA-330 WP_063862674.1 pubmed_reference: -> 24288029 blaOXA-331 WP_063862682.1 pubmed_reference: -> 24288029 blaOXA-332 WP_063862690.1 pubmed_reference: -> 24288029 blaOXA-333 WP_063862693.1 pubmed_reference: -> 24288029 blaOXA-334 WP_063862698.1 pubmed_reference: -> 24288029 blaOXA-335 WP_063862702.1 pubmed_reference: -> 24288029 blaOXA-348 WP_063862718.1 pubmed_reference: -> 24288029 blaOXA-349 WP_063862719.1 pubmed_reference: -> 24288029 blaOXA-350 WP_063862721.1 pubmed_reference: -> 24288029 blaOXA-351 WP_063862722.1 pubmed_reference: -> 24288029 blaOXA-352 WP_063862723.1 pubmed_reference: -> 24288029 blaOXA-353 WP_063862724.1 pubmed_reference: -> 24288029 blaOXA-354 WP_063862725.1 pubmed_reference: -> 24288029 blaOXA-355 WP_063862726.1 pubmed_reference: -> 24288029 blaOXA-356 WP_063862727.1 pubmed_reference: -> 24288029 blaOXA-357 WP_063862728.1 pubmed_reference: -> 24288029 blaOXA-358 WP_063862729.1 pubmed_reference: -> 24288029 blaOXA-359 WP_063862730.1 pubmed_reference: -> 24288029 blaOXA-360 WP_048880934.1 pubmed_reference: -> 24288029 blaOXA-361 WP_063862731.1 pubmed_reference: -> 24288029 blaOXA-362 WP_063862732.1 pubmed_reference: -> 24288029 blaOXA-363 WP_063862733.1 pubmed_reference: -> 24288029 blaOXA-439 WP_063864081.1 pubmed_reference: -> 35208713,35369469 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-470 WP_063864093.1 pubmed_reference: -> 26315325 blaOXA-498 WP_063454569.1 pubmed_reference: -> 27548264 blaOXA-504 WP_063864115.1 pubmed_reference: -> 26410172 blaOXA-517 WP_085562384.1 pubmed_reference: -> 35208713,36648230 blaOXA-519 WP_094009808.1 pubmed_reference: 29866857 -> 29866857,35208713 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-543 WP_058132644.1 pubmed_reference: -> 28658322 blaOXA-544 WP_071537493.1 pubmed_reference: -> 28658322 blaOXA-645 WP_140423314.1 pubmed_reference: -> 32273730 blaOXA-655 WP_122630842.1 product_name: OXA-10 family class D beta-lactamase OXA-655 -> OXA-10 family carbapenem-hydrolyzing class D beta-lactamase OXA-655 pubmed_reference: 30397053 -> 30397053,32683794 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-788 WP_136512084.1 pubmed_reference: -> 35208713 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-814 WP_005405613.1 pubmed_reference: -> 25763199 blaOXA-815 WP_111280830.1 pubmed_reference: -> 33799540 blaOXA-819 WP_032053762.1 pubmed_reference: -> 33799540 blaOXA-820 WP_032057042.1 pubmed_reference: -> 36034705 blaOXA-822 WP_133973918.1 pubmed_reference: -> 33201995 blaOXA-898 WP_154205589.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-915 WP_168370988.1 pubmed_reference: -> 33250496 blaOXA-957 WP_219860714.1 pubmed_reference: -> 36626997 synonyms: -> blaSSD blaPDC-221 WP_100931731.1 product_name: inhibitor-resistant class C beta-lactamase PDC-221 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-221 blaPDC-222 WP_100931732.1 product_name: inhibitor-resistant class C beta-lactamase PDC-222 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-222 blaPDC-223 WP_100931733.1 product_name: inhibitor-resistant class C beta-lactamase PDC-223 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-223 blaPDC-44 WP_034032599.1 product_name: class C beta-lactamase PDC-44 -> extended-spectrum class C beta-lactamase PDC-44 pubmed_reference: 25022578 -> 25022578,26248364 blaPDC-50 WP_034048369.1 product_name: class C beta-lactamase PDC-50 -> extended-spectrum class C beta-lactamase PDC-50 pubmed_reference: 25022578 -> 25022578,26248364 blaPDC-74 WP_040184286.1 product_name: class C beta-lactamase PDC-74 -> extended-spectrum class C beta-lactamase PDC-74 blaPDC-80 WP_058169253.1 product_name: inhibitor-resistant class C beta-lactamase PDC-80 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-80 blaPDC-86 WP_058198950.1 product_name: class C beta-lactamase PDC-86 -> extended-spectrum class C beta-lactamase PDC-86 blaPJM-1 WP_213603971.1 pubmed_reference: -> 35943258 blaPLA-1 WP_032699754.1 pubmed_reference: -> 14693555 subclass: BETA-LACTAM -> CEPHALOSPORIN blaRSA1-1 WP_223292485.1 pubmed_reference: -> 29316517 blaRSA2-1 WP_128268281.1 pubmed_reference: -> 29316517 blaRSC1-1 WP_128268282.1 pubmed_reference: -> 29316517 blaRSD1-1 WP_128268283.1 pubmed_reference: -> 29316517 blaRSD2-1 WP_128268284.1 pubmed_reference: -> 29316517 blaRSD2-2 WP_128268285.1 pubmed_reference: -> 29316517 blaSFC-2 WP_223174986.1 pubmed_reference: -> 35137119 blaSFDC-1 WP_218519361.1 product_name: class C beta-lactamase SFDC-1 -> extended-spectrum class C beta-lactamase SFDC-1 blaSFO-1 WP_032489477.1 pubmed_reference: -> 9925524 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSGM-1 WP_009821475.1 pubmed_reference: -> 23716045 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSLB-1 WP_063842915.1 subclass: BETA-LACTAM -> CARBAPENEM blaSMB-1 WP_063864723.1 pubmed_reference: 22442240 -> 21876060,22442240 subclass: BETA-LACTAM -> CARBAPENEM blaSRT-3 WP_033642964.1 pubmed_reference: -> 36140580 blaTEM-5 WP_109963600.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaTEM-61 WP_188240090.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaTEM-7 WP_109874025.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaTLA-1 WP_032494759.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaTLA-2 WP_011222052.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaTLA-3 WP_059512353.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaTRU-1 WP_042027926.1 subclass: CARBAPENEM -> CEPHALOSPORIN cepA-29 WP_063865204.1 pubmed_reference: -> 7517394 cepA-44 WP_032579291.1 pubmed_reference: -> 7517394 cepA-49 WP_008659027.1 pubmed_reference: -> 7517394 gyrA_D95A WP_003688895.1 pubmed_reference: 7830580 -> 7830580,36735316 gyrA_D95G WP_003688895.1 pubmed_reference: 7830580 -> 7830580,36735316 parC_E91G WP_010951227.1 pubmed_reference: 12529019 -> 12529019,36735316 Hierarchy nodes added core AMR AMR almE almE lipid A modification system glycine--protein ligase AlmE almF almF lipid A modification system glycine carrier protein AlmF ant(6)-Ig aadE-Cc aminoglycoside nucleotidyltransferase ANT(6)-Ig aph(2'')-Ii aph(2'')-Ii NF041446.1 aminoglycoside O-phosphotransferase APH(2'')-Ii blaRATA blaRATA NF041445.1 RATA family class A beta-lactamase fosBx1-fam fosB FosBx1 family fosfomycin resistance bacillithiol transferase fosXCC fosXCC fosfomycin resistance hydrolase FosXCC sal(D) sal(D) ABC-F type ribosomal protection protein Sal(D) sal(E) sal(E) ABC-F type ribosomal protection protein Sal(E) thfT thfT reduced folate ECF transporter S component ThfT vanS-I vanS-I VanI-type vancomycin resistance histidine kinase VanS vga(F) vga(F) ABC-F type ribosomal protection protein Vga(F) vga(G) vga(G) ABC-F type ribosomal protection protein Vga(G) Hierarchy nodes removed core AMR AMR aadE-Cc aadE-Cc NF033221.1 aminoglycoside 6-adenylyltransferase AadE-Cc lin lin lmo0919 family lincomycin resistance ABC-F type ribosomal protection protein plus STRESS METAL nirA nirA nickel resistance membrane nickel efflux protein NirA Changed Hierarchy Nodes almG glycine--lipid A transferase AlmG scope: plus -> core blaASU1 ASU1 family class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaB3SU1 B3SU1 family subclass B3 metallo-beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaB3SU2 B3SU2 family subclass B3 metallo-beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaL2 L2 family extended-spectrum class A beta-lactamase name: L2 family class A beta-lactamase -> L2 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN cfxA3 extended-spectrum class A beta-lactamase CfxA3 subclass: BETA-LACTAM -> CEPHALOSPORIN cfxA4 extended-spectrum class A beta-lactamase CfxA4 subclass: BETA-LACTAM -> CEPHALOSPORIN cfxA5 broad-spectrum class A beta-lactamase CfxA5 subclass: BETA-LACTAM -> CEPHALOSPORIN ---------------------------------------------------------------------- Changes included in 2022-12-19.1 ---------------------------------------------------------------------- Overview: - -o / --organism "Klebsiella" option split to "Klebsiella_pneumoniae" and "Klebsiella_oxytoca" - -o / --organism "Neisseria" option split to "Neisseria_gonorrhoeae" and "Neisseria_meningitidis" - Berkholderia blaPEN gene symbol reform based on review of Poirel, et al., 2009 (see below for curator explanation) - Many refined phenotypes ("class" and "subclasses") based on curation of the literature - New Klebsiella, Pseudomonas, and Acinetobacter point mutations NCBI has begun a restructuring of our handling of names for chromosomal class A beta-lactamases in the genus Burkholderia in order to increase clarity and better reflect usages in the literature that follow PMID: 19075063 (Poirel, et al., 2009). The gene symbols PenA and PenB are not instantly recognizable as beta-lactamases, since these have also been used for penicillin-binding proteins in Neisseria, and are now replaced with blaPEN-A and blaPEN-B. New HMMs resolve two subfamilies of blaPEN enzymes, from the Burkholderia cepacia complex (blaPEN-bcc, including PEN-A through PEN-H) and the Burkholderia pseudomallei complex (blaPEN-bpc, including PEN-I). Published allele designations in the PEN-A and PEN-B families take the format blaPEN-A1, blaPEN-B1, etc. We recommend using shorthand names that are capitalized and with hyphens, "PEN-A1" instead of "PenA1" to more closely resemble the handling of most other beta-lactamases. The proposal from Poirel, et al., 2009 provided enzyme names divided by species. In some cases, divisions between families are quite small, e.g. PEN-I for B. pseudomallei and PEN-K for B. mallei, despite only five amino acid differences between the suggested founding members those families. In general, NCBI remains skeptical of the potential overuse of chromosomal beta-lactamase names as proxies for species identification, in part because differences may be small, protein family structure is unclear when it depends on small differences, and new sequenced examples or changes to taxonomic assignments could invalidate previous assignments. Currently, we are in the process of adding more specific HMMs within the blaPEN-bcc or blaPEN-bpc complexes, as we did for blaPEN-A and blaPEN-B, if the usage seems well-established, member sequences abundant enough, and the separation from other families clear enough. We are interested in hearing feedback from the community on this effort, including the possibility of adding PEN-A (from Burkholderia multivorans) and PEN-B (from Burkholderia cenocepacia) to the NCBI managed allele submission and reservation system. Summary: Total proteins: 7597 Core proteins: 6499 Plus proteins: 1097 AMR proteins: 6548 STRESS proteins: 236 VIRULENCE proteins: 813 PubMed references: 2619 Point mutations: 1003 Point mutation reference sequences: 177 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Clostridioides_difficile, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 687 Updates since release 2022-10-11.2: Proteins added: 95 Core proteins added: 87 Plus proteins added: 8 AMR proteins added: 89 STRESS proteins added: 1 VIRULENCE proteins added: 5 Alleles added: 73 PubMed references added: 29 PubMed references removed: 2 Point mutations added: 12 Reference Gene Catalog entries changed: 353 Hierarchy nodes added: 26 Hierarchy nodes removed: 1 Hierarchy nodes changed: 36 Added proteins core AMR AMR blaIII NG_148591.1 WP_000497840.1 class A beta-lactamase BlaIII dfrA41 NG_148595.1 WP_004729503.1 trimethoprim-resistant dihydrofolate reductase DfrA41 rox NG_148600.1 WP_015031687.1 rifampin monooxygenase Rox dfrA40 NG_148594.1 WP_034702334.1 trimethoprim-resistant dihydrofolate reductase DfrA40 dfrA45 NG_148596.1 WP_049581834.1 trimethoprim-resistant dihydrofolate reductase DfrA45 blaPEN-N NG_148592.1 WP_060005294.1 PEN-N family class A beta-lactamase nimG NG_148598.1 WP_087312253.1 5-nitroimidazole reductase NimG msr(I) NG_148597.1 WP_198462967.1 ABC-F type ribosomal protection protein Msr(I) sal(B) NG_148601.1 WP_218688397.1 ABC-F type ribosomal protection protein Sal(B) sal(C) NG_148602.1 WP_218702729.1 ABC-F type ribosomal protection protein Sal(C) vanP NG_088565.1 WP_222891055.1 putative D-alanine--(R)-lactate ligase VanP vanS-P NG_088566.1 WP_222891058.1 VanP-type vancomycin resistance histidine kinase VanS crxA NG_148593.1 WP_262761957.1 CrxA family subclass B1 metallo-beta-lactamase nimK NG_148599.1 WP_268871842.1 5-nitroimidazole reductase NimK blaACT-110 NG_148603.1 WP_250127581.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-110 blaACT-111 NG_148604.1 WP_069720053.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-111 blaACT-91 NG_148605.1 WP_268871843.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-91 blaACT-92 NG_148606.1 WP_268871844.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-92 blaACT-93 NG_148607.1 WP_039261009.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-93 blaACT-94 NG_148608.1 WP_252029529.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-94 blaADC-286 NG_148609.1 WP_268871845.1 extended-spectrum class C beta-lactamase ADC-286 blaADC-287 NG_148610.1 WP_068613499.1 extended-spectrum class C beta-lactamase ADC-287 blaADC-288 NG_148611.1 WP_104074874.1 extended-spectrum class C beta-lactamase ADC-288 blaADC-289 NG_148612.1 WP_114270086.1 extended-spectrum class C beta-lactamase ADC-289 blaADC-290 NG_148613.1 WP_268871846.1 extended-spectrum class C beta-lactamase ADC-290 blaCMH-8 NG_148614.1 WP_268871847.1 class C beta-lactamase CMH-8 blaCMY-182 NG_148615.1 WP_103283398.1 class C beta-lactamase CMY-182 blaCMY-183 NG_148616.1 WP_048215094.1 class C beta-lactamase CMY-183 blaCMY-184 NG_148617.1 WP_268871848.1 class C beta-lactamase CMY-184 blaCTX-M-259 NG_088602.1 WP_263598085.1 extended-spectrum class A beta-lactamase CTX-M-259 blaFOX-21 NG_148618.1 WP_042058462.1 cephalosporin-hydrolyzing class C beta-lactamase FOX-21 blaGES-57 NG_148619.1 WP_268871850.1 class A beta-lactamase GES-57 blaIMP-98 NG_148620.1 WP_268871851.1 subclass B1 metallo-beta-lactamase IMP-98 blaKLUC-6 NG_148621.1 WP_268871852.1 extended-spectrum class A beta-lactamase KLUC-6 blaKPC-145 NG_148622.1 WP_268871853.1 class A beta-lactamase KPC-145 blaKPC-146 NG_148623.1 WP_268871854.1 carbapenem-hydrolyzing class A beta-lactamase KPC-146 blaKPC-147 NG_148624.1 WP_268871855.1 carbapenem-hydrolyzing class A beta-lactamase KPC-147 blaKPC-148 NG_148625.1 WP_264254632.1 class A beta-lactamase KPC-148 blaKPC-151 NG_148626.1 WP_268871856.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-151 blaKPC-153 NG_148627.1 WP_268871857.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-153 blaMOX-18 NG_148628.1 WP_268871858.1 CMY-1/MOX family class C beta-lactamase MOX-18 blaMOX-19 NG_148629.1 WP_268871859.1 CMY-1/MOX family class C beta-lactamase MOX-19 blaMOX-20 NG_148630.1 WP_268871860.1 CMY-1/MOX family class C beta-lactamase MOX-20 blaMOX-21 NG_148631.1 WP_268871861.1 CMY-1/MOX family class C beta-lactamase MOX-21 blaMOX-22 NG_148632.1 WP_223915751.1 CMY-1/MOX family class C beta-lactamase MOX-22 blaMOX-23 NG_148633.1 WP_180898621.1 CMY-1/MOX family class C beta-lactamase MOX-23 blaMOX-24 NG_148634.1 WP_244054059.1 CMY-1/MOX family class C beta-lactamase MOX-24 blaMOX-25 NG_148635.1 WP_128343957.1 CMY-1/MOX family class C beta-lactamase MOX-25 blaNDM-45 NG_148636.1 WP_268871862.1 subclass B1 metallo-beta-lactamase NDM-45 blaNDM-46 NG_148637.1 WP_268871863.1 subclass B1 metallo-beta-lactamase NDM-46 blaNDM-47 NG_148638.1 WP_268871864.1 subclass B1 metallo-beta-lactamase NDM-47 blaNDM-48 NG_148639.1 WP_268871865.1 subclass B1 metallo-beta-lactamase NDM-48 blaOXA-1152 NG_148640.1 WP_150662373.1 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1152 blaOXA-1153 NG_148641.1 WP_134696937.1 class D beta-lactamase OXA-1153 blaOXA-1154 NG_148642.1 WP_268871866.1 class D beta-lactamase OXA-1154 blaOXA-1155 NG_148643.1 WP_268871867.1 class D beta-lactamase OXA-1155 blaOXA-1156 NG_148644.1 WP_268871868.1 class D beta-lactamase OXA-1156 blaOXA-1157 NG_148645.1 WP_268871869.1 OXA-12 family class D beta-lactamase OXA-1157 blaOXA-1158 NG_148646.1 WP_268871870.1 class D beta-lactamase OXA-1158 blaOXA-1159 NG_148647.1 WP_052815145.1 class D beta-lactamase OXA-1159 blaOXA-1160 NG_148648.1 WP_010672256.1 class D beta-lactamase OXA-1160 blaOXA-1161 NG_148649.1 WP_151027527.1 class D beta-lactamase OXA-1161 blaOXA-1162 NG_148650.1 WP_139462269.1 OXA-12 family class D beta-lactamase OXA-1162 blaOXA-1163 NG_148651.1 WP_042016119.1 class D beta-lactamase OXA-1163 blaOXA-1164 NG_148652.1 WP_268871871.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1164 blaOXA-1165 NG_148653.1 WP_268871872.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1165 blaOXA-1166 NG_148654.1 WP_104074618.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1166 blaOXA-1168 NG_148655.1 WP_268871873.1 OXA-10 family class D beta-lactamase OXA-1168 blaOXA-1169 NG_148656.1 WP_268871874.1 OXA-10 family class D beta-lactamase OXA-1169 blaOXA-1170 NG_148657.1 WP_268871875.1 OXA-10 family class D beta-lactamase OXA-1170 blaOXA-1171 NG_148658.1 WP_268871876.1 OXA-10 family class D beta-lactamase OXA-1171 blaOXA-1172 NG_148659.1 WP_268871877.1 OXA-2 family class D beta-lactamase OXA-1172 blaOXA-1173 NG_148660.1 WP_268871878.1 OXA-2 family class D beta-lactamase OXA-1173 blaOXA-1174 NG_148661.1 WP_057384527.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1174 blaOXA-1175 NG_148662.1 WP_268871879.1 OXA-10 family class D beta-lactamase OXA-1175 blaOXA-1176 NG_148663.1 WP_268871880.1 OXA-60 family carbapenem-hydrolyzing class D beta-lactamase OXA-1176 blaOXA-1177 NG_148664.1 WP_268871881.1 OXA-22 family class D beta-lactamase OXA-1177 blaOXA-1178 NG_148665.1 WP_268871882.1 OXA-58 family carbapenem-hydrolyzing class D beta-lactamase OXA-1178 blaOXA-1183 NG_148666.1 WP_117407753.1 OXA-2 family class D beta-lactamase OXA-1183 blaOXA-1184 NG_148667.1 WP_263096442.1 OXA-10 family class D beta-lactamase OXA-1184 blaPDC-534 NG_148668.1 WP_268871884.1 class C beta-lactamase PDC-534 blaPDC-535 NG_148669.1 WP_126590471.1 class C beta-lactamase PDC-535 blaPDC-536 NG_148670.1 WP_268871885.1 class C beta-lactamase PDC-536 blaPDC-537 NG_148671.1 WP_243210688.1 class C beta-lactamase PDC-537 blaPFM-4 NG_148672.1 WP_198799270.1 subclass B2 metallo-beta-lactamase PFM-4 blaSHV-230 NG_148673.1 WP_268871888.1 class A beta-lactamase SHV-230 blaSHV-231 NG_148674.1 WP_268871889.1 class A beta-lactamase SHV-231 plus AMR AMR cph U13078.1 AAA92037.1 capreomycin phosphotransferase helR FR845719.1 CCA59315.1 RNA polymerase recycling motor ATPase HelR plus STRESS HEAT clpK KY887595.1 ASF80763.1 heat shock survival AAA family ATPase ClpK plus VIRULENCE VIRULENCE stxB2h CP022279.1 AUM09787.1 Shiga toxin Stx2h subunit B stxA2h CP022279.1 AUM09788.1 Shiga toxin Stx2h subunit A stxA2i FN252457.1 CAX53241.1 Shiga toxin Stx2i subunit A stxB2i FN252457.1 CAX53242.1 Shiga toxin Stx2i subunit B stxA2j MZ571121.1 QZN05543.1 Shiga toxin Stx2j subunit A Added point mutations core AMR POINT blaOXY_G-34A CEPHALOSPORIN Klebsiella_oxytoca blaOXY_G-38T CEPHALOSPORIN Klebsiella_oxytoca blaOXY_T-58A CEPHALOSPORIN Klebsiella_oxytoca blaOXY_T-67C CEPHALOSPORIN Klebsiella_oxytoca cirA_G75W CEFIDEROCOL Klebsiella_pneumoniae cirA_W427STOP CEFIDEROCOL Klebsiella_pneumoniae cirA_Y253CfsTer5 CEFIDEROCOL Klebsiella_pneumoniae oprD_W339STOP CARBAPENEM Pseudomonas_aeruginosa oprD_W65STOP CARBAPENEM Pseudomonas_aeruginosa oprD_Y283STOP CARBAPENEM Pseudomonas_aeruginosa pmrB_A226T COLISTIN Acinetobacter_baumannii pmrC_R125P COLISTIN Acinetobacter_baumannii Changed reference gene catalog records kdeA ABR76310.1 blacklisted_taxa: Klebsiella -> Klebsiella_pneumoniae arsC BAA24824.1 blacklisted_taxa: Escherichia, Klebsiella -> Escherichia, Klebsiella_oxytoca fieF BAB89353.1 blacklisted_taxa: Klebsiella -> Klebsiella_oxytoca stxA2l CAP17609.1 gene_family: stxA2e -> stxA2l hierarchy_node: stxA2e -> stxA2l product_name: Shiga toxin Stx2e subunit A -> Shiga toxin Stx2l subunit A subclass: STX2E -> STX2L cfr WP_001010505.1 class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMUTILIN spw WP_002294509.1 curated_refseq_start: No -> Yes genbank_nucleotide_accession: AFQJ01000004.1 -> CP024781.1 genbank_protein_accession: EGP12870.1 -> genbank_start: 648813 -> 1553414 genbank_stop: 649622 -> 1554223 pbp2 WP_003703066.1 product_name: Neisseria penicillin-binding protein PBP2 -> Neisseria gonorrhoeae penicillin-binding protein PBP2 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae nimE WP_005812773.1 product_name: nitroimidazole resistance protein NimE -> 5-nitroimidazole reductase NimE nimJ WP_005812825.1 product_name: nitroimidazole resistance protein NimJ -> 5-nitroimidazole reductase NimJ blaPEN-M WP_006027381.1 gene_family: blaPEN-bpc -> blaPEN-M hierarchy_node: blaPEN-bpc -> blaPEN-M product_name: PEN family class A beta-lactamase, Bpc-type -> PEN-M family class A beta-lactamase blaPEN-J WP_010108817.1 product_name: class A beta-lactamase PEN-J -> PEN-J family class A beta-lactamase tetB WP_011116970.1 gene_family: tetAB_B -> tetB rox WP_011210071.1 hierarchy_node: rox -> rox_nf nimI WP_021588763.1 product_name: nitroimidazole resistance protein NimI -> 5-nitroimidazole reductase NimI aac(6') WP_023417224.1 genbank_nucleotide_accession: ASHF01000011.1 -> CP106650.1 genbank_start: 464699 -> 2183753 genbank_stop: 465181 -> 2184235 refseq_nucleotide_accession: NG_052413.1 -> NG_148590.1 blaPEN-L WP_025370306.1 product_name: class A beta-lactamase PEN-L -> PEN-L family class A beta-lactamase nimA WP_032488596.1 product_name: nitroimidazole resistance protein NimA -> 5-nitroimidazole reductase NimA cfr WP_032491462.1 class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> pubmed_reference: -> 16801432 subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMUTILIN mecA WP_057521704.1 hierarchy_node: mecA -> mecA-ceftar product_name: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -> ceftaroline-resistant PBP2a family peptidoglycan transpeptidase MecA pubmed_reference: -> 24777906 subclass: METHICILLIN -> CEFTAROLINE/METHICILLIN synonyms: pbp2A -> mecA WP_063852670.1 pubmed_reference: -> 24777906 subclass: METHICILLIN -> CEFTAROLINE/METHICILLIN mecA WP_063852677.1 pubmed_reference: -> 24777906 subclass: METHICILLIN -> CEFTAROLINE/METHICILLIN mecA WP_063852683.1 pubmed_reference: -> 24777906 subclass: METHICILLIN -> CEFTAROLINE/METHICILLIN nimB WP_063854490.1 product_name: nitroimidazole resistance protein NimB -> 5-nitroimidazole reductase NimB nimC WP_063854491.1 product_name: nitroimidazole resistance protein NimC -> 5-nitroimidazole reductase NimC nimD WP_063854492.1 product_name: nitroimidazole resistance protein NimD -> 5-nitroimidazole reductase NimD blaPEN-I WP_063854501.1 product_name: class A beta-lactamase PEN-I -> PEN-I family class A beta-lactamase sal(A) WP_063854920.1 class: LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN 16S_C1191T NZ_AP019853.2 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae 23S_A2045G NC_002946.2 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae 23S_A2057G NC_002946.2 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae 23S_A2145G NC_002946.2 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae 23S_C2597T NC_002946.2 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae acrR_M109I WP_002892080.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae acrR_V165I WP_002892080.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae acrR_Y114F WP_002892080.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae arnC_C161Y WP_014906821.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae blaNWM-1 WP_256875606.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1000 WP_231869625.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1002 WP_231869626.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1003 WP_231869627.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1007 WP_231869630.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1008 WP_231869631.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1009 WP_231869632.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1010 WP_231869633.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1045 WP_046811527.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1050 WP_240067730.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1137 WP_256875619.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1138 WP_256875620.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1150 WP_119685493.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1151 WP_262697150.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-514 WP_094009803.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-515 WP_094009804.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-517 WP_085562384.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-535 WP_089067012.1 pubmed_reference: -> 29038283 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-545 WP_085562402.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-547 WP_085562403.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-678 WP_122630860.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-777 WP_122630923.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-778 WP_122630924.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-801 WP_136512092.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-802 WP_136512093.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-803 WP_136512094.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-804 WP_136512095.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-805 WP_136512096.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-819 WP_032053762.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-820 WP_032057042.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-821 WP_057061999.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-822 WP_133973918.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-825 WP_140423318.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-826 WP_140423319.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-832 WP_086264536.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-840 WP_150823472.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-841 WP_150823473.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-842 WP_087088911.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-843 WP_150823474.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-844 WP_150823475.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-894 WP_144376393.1 pubmed_reference: -> 31597235 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-935 WP_141989064.1 pubmed_reference: -> 36129295 blaOXA-941 WP_086395021.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-942 WP_078225401.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-943 WP_086398931.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-978 WP_231869604.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-979 WP_231869605.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-980 WP_081174195.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-985 WP_231869610.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-986 WP_231869611.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-987 WP_231869612.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-988 WP_231869613.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-989 WP_231869614.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-990 WP_231869615.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-992 WP_231869617.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXY-1-1 WP_014228247.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-10 WP_049079240.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-11 WP_049082137.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-12 WP_057174064.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-13 WP_080528555.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-14 WP_088168768.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-15 WP_119834461.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-16 WP_160741710.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-17 WP_162121893.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-18 WP_185219566.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-19 WP_196575333.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-2 WP_025107110.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-3 WP_063864545.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-4 WP_049101515.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-6 WP_063864546.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-7 WP_102803085.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-8 WP_032748514.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1-9 WP_064378351.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-10-1 WP_110273168.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-11-1 WP_154679523.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-12-1 WP_181483194.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-12-2 WP_182237112.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-1 WP_032727905.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-10 WP_063864547.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-11 WP_004111091.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-12 WP_063864548.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-13 WP_063864549.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-14 WP_063842752.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-16 WP_023320486.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-17 WP_256875623.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-18 WP_064396914.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-19 WP_256875624.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-2 WP_023329386.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-20 WP_163530110.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-21 WP_049127974.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-22 WP_064344965.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-23 WP_064361275.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-24 WP_064375196.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-25 WP_097365603.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-26 WP_126488681.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-27 WP_196090373.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-28 WP_256875625.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-3 WP_063864551.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-30 WP_241700785.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-4 WP_004099854.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-5 WP_063842759.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-6 WP_063864552.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-7 WP_017146441.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-8 WP_053064676.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2-9 WP_063864553.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-3-1 WP_063864554.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-3-2 WP_142464024.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-3-3 WP_142981135.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-4-1 WP_004130122.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-4-2 WP_142446236.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-4-3 WP_142467842.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-4-4 WP_142471056.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-4-5 WP_142481206.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-1 WP_063864555.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-10 WP_186384957.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-11 WP_197663517.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-2 WP_009652647.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-3 WP_049074725.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-4 WP_004848499.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-5 WP_109213213.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-6 WP_177340503.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-7 WP_181251167.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-8 WP_182012076.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5-9 WP_182409324.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-1 WP_063864556.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-10 WP_181246811.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-11 WP_181511480.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-2 WP_063864557.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-3 WP_063864558.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-4 WP_004137840.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-5 WP_024358907.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-6 WP_049088977.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-7 WP_098066351.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-8 WP_154951884.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6-9 WP_155037090.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-7-1 WP_256875626.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-8-1 WP_112215366.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-8-2 WP_142515482.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-8-3 WP_142512117.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-9-1 WP_142465578.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaPDC-459 WP_197749408.1 product_name: class C beta-lactamase PDC-459 -> extended-spectrum class C beta-lactamase PDC-459 pubmed_reference: -> 36073814 blaPDC-460 WP_197749409.1 product_name: class C beta-lactamase PDC-460 -> extended-spectrum class C beta-lactamase PDC-460 pubmed_reference: -> 36073814 blaPDC-461 WP_197749410.1 product_name: class C beta-lactamase PDC-461 -> extended-spectrum class C beta-lactamase PDC-461 pubmed_reference: -> 36073814 blaPDC-462 WP_197749411.1 product_name: class C beta-lactamase PDC-462 -> extended-spectrum class C beta-lactamase PDC-462 pubmed_reference: -> 36073814 blaPDC-463 WP_197749412.1 product_name: class C beta-lactamase PDC-463 -> extended-spectrum class C beta-lactamase PDC-463 pubmed_reference: -> 36073814 blaPDC-464 WP_197749413.1 product_name: class C beta-lactamase PDC-464 -> extended-spectrum class C beta-lactamase PDC-464 pubmed_reference: -> 36073814 blaTEM-230 WP_104009854.1 product_name: class A beta-lactamase TEM-230 -> extended-spectrum class A beta-lactamase TEM-230 subclass: BETA-LACTAM -> CEPHALOSPORIN crrB_F84S WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_G183V WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_L94M WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_N141I WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_N141Y WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_P151L WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_P151S WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_Q10L WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_S195N WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_W140R WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae crrB_Y31H WP_004184324.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae folP_R228S WP_003702942.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae gyrA_D87A WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_D87G WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_D87H WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_D87N WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_D87Y WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_D95A WP_003688895.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae gyrA_D95G WP_003688895.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae gyrA_D95N WP_002240607.1 pubmed_reference: 10799008,7830580 -> 10799008 whitelisted_taxa: Neisseria -> Neisseria_meningitidis gyrA_D95N WP_003688895.1 pubmed_reference: 10799008,7830580 -> 7830580 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae gyrA_S83F WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_S83I WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_S83L WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_S83T WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_S83Y WP_117036963.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae gyrA_S91F WP_003688895.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae gyrA_T173A WP_002240607.1 whitelisted_taxa: Neisseria -> Neisseria_meningitidis gyrA_T91I WP_002240607.1 whitelisted_taxa: Neisseria -> Neisseria_meningitidis gyrB_D429N WP_050171206.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae gyrB_K450N WP_050171206.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae gyrB_K450T WP_050171206.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae lapB_V43G WP_004140292.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae lpxM_V30G WP_002911442.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae macAB_G-48T NZ_AP023073.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae mgrB_A14S WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_C28F WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_C28Y WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_C39STOP WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_C39Y WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_D31N WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_F35I WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_G37S WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_I45T WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_L17R WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_L24H WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_M27K WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_Q30STOP WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_V32G WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_W20R WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mgrB_W47R WP_002911375.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae mtrC_C-120T NZ_CP012026.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae mtrR_A-53del NZ_CP043871.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae mtrR_A-56C NZ_CP043871.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae mtrR_A39T WP_047924300.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae mtrR_G-131A NZ_CP043871.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae mtrR_G45D WP_047924300.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae norM_A-7G NZ_AP023073.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae norM_C-104T NZ_AP023073.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae ompK35_E132K WP_004141771.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK35_W230STOP WP_004141771.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_D135DD WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_D135DGD WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_E78STOP WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_G133D WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_T126STOP WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_T136TDT WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_T192del WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_T261STOP WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_T333N WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ompK36_W125STOP WP_002913005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae oqxR_D95E WP_000888203.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae oqxR_F6S WP_000888203.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae oqxR_Q11L WP_000888203.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae oqxR_V102G WP_000888203.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae oqxR_V113I WP_000888203.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae parC_D86N WP_010951227.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae parC_E84K WP_101982161.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae parC_E91G WP_010951227.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae parC_E91K WP_010951227.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae parC_S80I WP_101982161.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae parC_S87I WP_010951227.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae parC_S87N WP_010951227.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae parC_S87R WP_010951227.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae parC_S88P WP_010951227.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae parE_G410V WP_003691666.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_A311V WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_A501AA WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_A501P WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_A501T WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_A501V WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_A510V WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_A516G WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_D346DD WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_F504L WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_G542S WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_G545S WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_I312M WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_N512Y WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_P551L WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_P551S WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_T483S WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_V316P WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae penA_V316T WP_003693546.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae phoP_D191Y WP_004150807.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoP_I201N WP_004150807.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoP_V3F WP_004150807.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_A20P WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_A20S WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_D266DD WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_D438N WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_G385S WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_L26P WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_L348Q WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_L396Q WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_L96P WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_R16C WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_S174N WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae phoQ_S56R WP_004147969.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrA_G53C WP_002895659.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrA_G53S WP_002895659.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrA_S42N WP_002895659.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_ALNQLV129del WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_D313N WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_L17Q WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_L82R WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_R14del WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_R256G WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_S208N WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_S85R WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_T140P WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_T157P WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae pmrB_Y209del WP_004179093.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ponA_L421P WP_003687357.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae porB1b_A121D WP_106333382.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae porB1b_A121H WP_106333382.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae porB1b_A121N WP_106333382.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae porB1b_A121P WP_106333382.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae porB1b_G120D WP_106333382.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae porB1b_G120K WP_106333382.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae porB1b_G120P WP_106333382.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae porB1b_G120R WP_106333382.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae ramR_A16D WP_004176968.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ramR_A183D WP_004176968.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ramR_A19V WP_004176968.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ramR_I88N WP_004176968.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ramR_K5E WP_004176968.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ramR_T162I WP_004176968.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae ramR_T43M WP_004176968.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae rplD_G70D WP_003690088.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rplV_K83KKGPSLK WP_002215424.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rplV_K90KARAK WP_002215424.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpoB_D543V WP_002225943.1 whitelisted_taxa: Neisseria -> Neisseria_meningitidis rpoB_G158V WP_003690105.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpoB_H553N WP_002225943.1 whitelisted_taxa: Neisseria -> Neisseria_meningitidis rpoB_H553R WP_002225943.1 whitelisted_taxa: Neisseria -> Neisseria_meningitidis rpoB_H553Y WP_002225943.1 whitelisted_taxa: Neisseria -> Neisseria_meningitidis rpoB_P157L WP_003690105.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpoB_R201H WP_003690105.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpoB_S549F WP_002225943.1 whitelisted_taxa: Neisseria -> Neisseria_meningitidis rpoB_S558F WP_002225943.1 whitelisted_taxa: Neisseria -> Neisseria_meningitidis rpoD_DDDA92del WP_003688264.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpoD_E98K WP_003688264.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpsE_K28E WP_002215445.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpsE_T24P WP_002215445.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpsE_V27del WP_002215445.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpsJ_V57L WP_001181005.1 whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae rpsJ_V57L WP_002215394.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpsJ_V57M WP_002215394.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae rpsJ_V57Q WP_002215394.1 whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae Hierarchy nodes added core AMR AMR bla-B1_long bla NF041269.1 subclass B1 metallo-beta-lactamase, long type blaIII blaIII NF041270.1 class A beta-lactamase BlaIII blaPEN-M blaPEN-M PEN-M family class A beta-lactamase blaPEN-N blaPEN-N NF041253.1 PEN-N family class A beta-lactamase crxA crxA CrxA family subclass B1 metallo-beta-lactamase dfrA40 dfrA40 trimethoprim-resistant dihydrofolate reductase DfrA40 dfrA41 dfrA41 trimethoprim-resistant dihydrofolate reductase DfrA41 dfrA45 dfrA45 trimethoprim-resistant dihydrofolate reductase DfrA45 msr(I) msr(I) ABC-F type ribosomal protection protein Msr(I) nimG nimG 5-nitroimidazole reductase NimG nimK nimK 5-nitroimidazole reductase NimK rox_nf rox rifampin monooxygenase Rox rox_sv rox rifampin monooxygenase Rox sal(B) sal(B) ABC-F type ribosomal protection protein Sal(B) sal(C) sal(C) ABC-F type ribosomal protection protein Sal(C) vanP vanP putative D-alanine--(R)-lactate ligase VanP vanS-P vanS-P VanP-type vancomycin resistance histidine kinase VanS plus AMR AMR cph cph NF041268.1 capreomycin phosphotransferase helR helR NF041254.1 RNA polymerase recycling motor ATPase HelR plus STRESS HEAT clpK clpK NF033606.1 heat shock survival AAA family ATPase ClpK plus VIRULENCE VIRULENCE stxA2h stxA2h Shiga toxin Stx2h subunit A stxA2i stxA2i Shiga toxin Stx2i subunit A stxA2j stxA2j Shiga toxin Stx2j subunit A stxA2l stxA2l Shiga toxin Stx2l subunit A stxB2h stxB2h Shiga toxin Stx2h subunit B stxB2i stxB2i Shiga toxin Stx2i subunit B Hierarchy nodes removed core AMR AMR rox rox rifampin monooxygenase Rox Changed Hierarchy Nodes blaOXA-213_fam OXA-213 family carbapenem-hydrolyzing class D beta-lactamase subclass: BETA-LACTAM -> CARBAPENEM blaOXA-58_fam OXA-58 family carbapenem-hydrolyzing class D beta-lactamase subclass: BETA-LACTAM -> CARBAPENEM blaOXA-5_fam OXA-5 family class D beta-lactamase hmm_acc: NF040527.1 -> NF040527.2 blaOXY OXY family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-1 OXY-1 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-10 OXY-10 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-11 OXY-11 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-12 OXY-12 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-2 OXY-2 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-3 OXY-3 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-4 OXY-4 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-5 OXY-5 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-6 OXY-6 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-7 OXY-7 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-8 OXY-8 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXY-9 OXY-9 family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaPEN-I PEN-I family class A beta-lactamase name: class A beta-lactamase PEN-I -> PEN-I family class A beta-lactamase blaPEN-J PEN-J family class A beta-lactamase name: class A beta-lactamase PEN-J -> PEN-J family class A beta-lactamase blaPEN-L PEN-L family class A beta-lactamase name: class A beta-lactamase PEN-L -> PEN-L family class A beta-lactamase cfr 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr class: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONES/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/CLINDAMYCIN/LINEZOLID/TIAMUTILIN/STREPTOGRAMIN cmx_cmrA Cmx/CmrA family chloramphenicol efflux MFS transporter symbol: cmx_cmrA -> cml garos_AAA garosamine-type aminoglycoside resistance ATP-binding protein symbol: gar_fam -> gar mecA-ceftar ceftaroline-resistant PBP2a family peptidoglycan transpeptidase MecA subclass: METHICILLIN -> CEFTAROLINE/METHICILLIN nimA 5-nitroimidazole reductase NimA name: nitroimidazole resistance protein NimA -> 5-nitroimidazole reductase NimA nimABCDEF NimABCDEF family 5-nitroimidazole reductase name: NimABCDEF family nitroimidazole resistance protein -> NimABCDEF family 5-nitroimidazole reductase nimB 5-nitroimidazole reductase NimB name: nitroimidazole resistance protein NimB -> 5-nitroimidazole reductase NimB nimC 5-nitroimidazole reductase NimC name: nitroimidazole resistance protein NimC -> 5-nitroimidazole reductase NimC nimD 5-nitroimidazole reductase NimD name: nitroimidazole resistance protein NimD -> 5-nitroimidazole reductase NimD nimE 5-nitroimidazole reductase NimE name: nitroimidazole resistance protein NimE -> 5-nitroimidazole reductase NimE nimI 5-nitroimidazole reductase NimI name: nitroimidazole resistance protein NimI -> 5-nitroimidazole reductase NimI nimIJ NimIJ family 5-nitroimidazole reductase name: NimIJ family nitroimidazole resistance protein -> NimIJ family 5-nitroimidazole reductase nimJ 5-nitroimidazole reductase NimJ name: nitroimidazole resistance protein NimJ -> 5-nitroimidazole reductase NimJ sal Sal family ABC-F type ribosomal protection protein class: LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN hmm_acc: NF000169.1 -> NF000169.2 subclass: LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN sal(A) ABC-F type ribosomal protection protein Sal(A) class: LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN subclass: LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN tet(M-W-O-S) TetM/TetW/TetO/TetS family tetracycline resistance ribosomal protection protein symbol: tet_rib_protect -> tet tetAB_B tetracycline efflux ABC transporter TetAB subunit B symbol: tetAB_B -> tetB ---------------------------------------------------------------------- Changes included in 2022-10-11.2 ---------------------------------------------------------------------- Overview: - Several changes to blaPEN family to bring the database contents and nomenclature to conform with Poirel 2009 (PMID:19075063) this work is not complete, but should be complete for the next release - Several HMM updates including 6 new HMMs and 2 updates to existing HMMs - Curators reviewed blaKPC phenotypes and made some updates - Reorganization of names of van genes to make them consistent with our AMR gene standards - Vibrio enterotoxin genes ctxA and ctxB added - WP_003410677.1 gene symbol was corrected to blaC to conform with other databases Summary: Total proteins: 7502 Core proteins: 6412 Plus proteins: 1089 AMR proteins: 6459 STRESS proteins: 235 VIRULENCE proteins: 808 PubMed references: 2592 Point mutations: 991 Point mutation reference sequences: 173 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Clostridioides_difficile, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 681 Updates since release 2022-08-09.1: Proteins added: 128 Core proteins added: 126 Plus proteins added: 2 AMR proteins added: 126 VIRULENCE proteins added: 2 Alleles added: 119 PubMed references added: 7 Reference Gene Catalog entries changed: 40 Hierarchy nodes added: 22 Hierarchy nodes removed: 3 Hierarchy nodes changed: 18 Added proteins core AMR AMR blaMAB NG_088376.1 WP_005091054.1 MAB family class A beta-lactamase blaPEN-F NG_088378.1 WP_011659342.1 PEN-F family class A beta-lactamase blaPEN-E NG_088377.1 WP_011882713.1 PEN-E family class A beta-lactamase mcr-3 NG_088379.1 WP_042649073.1 MCR-3-related phosphoethanolamine--lipid A transferase vanH-P NG_088380.1 WP_222891054.1 D-lactate dehydrogenase VanH-P vanX-P NG_088382.1 WP_222891056.1 D-Ala-D-Ala dipeptidase VanX-P vanR-P NG_088381.1 WP_222891057.1 vancomycin resistance response regulator transcription factor VanR-P aac(6')-Iap NG_088375.1 WP_262697082.1 aminoglycoside 6'-N-acetyltransferase AAC(6')-Iap blaADC-283 NG_081788.1 WP_257394578.1 extended-spectrum class C beta-lactamase ADC-283 blaADC-284 NG_088383.1 WP_115434994.1 extended-spectrum class C beta-lactamase ADC-284 blaADC-285 NG_088384.1 WP_262697121.1 extended-spectrum class C beta-lactamase ADC-285 blaCTX-M-257 NG_088385.1 WP_262697122.1 extended-spectrum class A beta-lactamase CTX-M-257 blaCTX-M-258 NG_088386.1 WP_262697123.1 extended-spectrum class A beta-lactamase CTX-M-258 blaEBR-5 NG_088387.1 WP_260543444.1 subclass B1 metallo-beta-lactamase EBR-5 blaFOX-20 NG_088388.1 WP_262697125.1 cephalosporin-hydrolyzing class C beta-lactamase FOX-20 blaFRI-12 NG_081789.1 WP_257394579.1 carbapenem-hydrolyzing class A beta-lactamase FRI-12 blaGES-56 NG_088389.1 WP_262697126.1 class A beta-lactamase GES-56 blaGIM-3 NG_088390.1 WP_262697127.1 subclass B1 metallo-beta-lactamase GIM-3 blaHMB-2 NG_088391.1 WP_079767532.1 subclass B1 metallo-beta-lactamase HMB-2 blaIMP-97 NG_088392.1 WP_262697128.1 subclass B1 metallo-beta-lactamase IMP-97 blaKBL-1 NG_088393.1 WP_137138291.1 class A beta-lactamase KBL-1 blaKPC-101 NG_088394.1 WP_262697129.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-101 blaKPC-110 NG_088395.1 WP_257394580.1 inhibitor-resistant class A beta-lactamase KPC-110 blaKPC-111 NG_081791.1 WP_257394581.1 inhibitor-resistant class A beta-lactamase KPC-111 blaKPC-134 NG_088396.1 WP_262697130.1 inhibitor-resistant class A beta-lactamase KPC-134 blaKPC-135 NG_088397.1 WP_262697131.1 inhibitor-resistant class A beta-lactamase KPC-135 blaKPC-138 NG_088398.1 WP_262697133.1 inhibitor-resistant extended-spectrum class A beta-lactamase KPC-138 blaKPC-139 NG_088399.1 WP_262697134.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-139 blaKPC-140 NG_088400.1 WP_262697135.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-140 blaKPC-141 NG_088401.1 WP_262697136.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-141 blaKPC-142 NG_088402.1 WP_262697137.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-142 blaKPC-143 NG_088403.1 WP_262697138.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-143 blaKPC-144 NG_088404.1 WP_262697139.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-144 blaKPC-99 NG_088405.1 WP_262697140.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-99 blaMIR-24 NG_088406.1 WP_087855277.1 cephalosporin-hydrolyzing class C beta-lactamase MIR-24 blaMIR-25 NG_088407.1 WP_021240723.1 cephalosporin-hydrolyzing class C beta-lactamase MIR-25 blaMOX-17 NG_088408.1 WP_262697141.1 CMY-1/MOX family class C beta-lactamase MOX-17 blaNDM-44 NG_088409.1 WP_262697142.1 subclass B1 metallo-beta-lactamase NDM-44 blaOXA-1140 NG_081792.1 WP_241469308.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1140 blaOXA-1141 NG_081793.1 WP_257394582.1 OXA-10 family class D beta-lactamase OXA-1141 blaOXA-1142 NG_081794.1 WP_257394583.1 class D beta-lactamase OXA-1142 blaOXA-1143 NG_081795.1 WP_171865690.1 class D beta-lactamase OXA-1143 blaOXA-1144 NG_081796.1 WP_046759755.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1144 blaOXA-1145 NG_081797.1 WP_257394584.1 OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-1145 blaOXA-1146 NG_088410.1 WP_262697143.1 OXA-48 family class D beta-lactamase OXA-1146 blaOXA-1147 NG_088411.1 WP_262697144.1 OXA-10 family class D beta-lactamase OXA-1147 blaOXA-1148 NG_088412.1 WP_262697145.1 OXA-10 family class D beta-lactamase OXA-1148 blaOXA-1149 NG_088413.1 WP_150664304.1 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1149 blaOXA-1150 NG_088414.1 WP_119685493.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1150 blaOXA-1151 NG_088415.1 WP_262697150.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1151 blaOXY-1-10 NG_088416.1 WP_049079240.1 extended-spectrum class A beta-lactamase OXY-1-10 blaOXY-1-14 NG_088417.1 WP_088168768.1 extended-spectrum class A beta-lactamase OXY-1-14 blaOXY-1-15 NG_088418.1 WP_119834461.1 extended-spectrum class A beta-lactamase OXY-1-15 blaOXY-1-16 NG_088419.1 WP_160741710.1 extended-spectrum class A beta-lactamase OXY-1-16 blaOXY-1-19 NG_088420.1 WP_196575333.1 extended-spectrum class A beta-lactamase OXY-1-19 blaOXY-1-7 NG_088421.1 WP_102803085.1 extended-spectrum class A beta-lactamase OXY-1-7 blaOXY-1-8 NG_088422.1 WP_032748514.1 extended-spectrum class A beta-lactamase OXY-1-8 blaOXY-1-9 NG_088423.1 WP_064378351.1 extended-spectrum class A beta-lactamase OXY-1-9 blaOXY-10-1 NG_088424.1 WP_110273168.1 extended-spectrum class A beta-lactamase OXY-10-1 blaOXY-12-2 NG_088425.1 WP_182237112.1 extended-spectrum class A beta-lactamase OXY-12-2 blaOXY-2-16 NG_088426.1 WP_023320486.1 extended-spectrum class A beta-lactamase OXY-2-16 blaOXY-2-20 NG_088427.1 WP_163530110.1 extended-spectrum class A beta-lactamase OXY-2-20 blaOXY-2-25 NG_088428.1 WP_097365603.1 extended-spectrum class A beta-lactamase OXY-2-25 blaOXY-2-27 NG_088429.1 WP_196090373.1 extended-spectrum class A beta-lactamase OXY-2-27 blaOXY-5-10 NG_088430.1 WP_186384957.1 extended-spectrum class A beta-lactamase OXY-5-10 blaOXY-5-3 NG_088431.1 WP_049074725.1 extended-spectrum class A beta-lactamase OXY-5-3 blaOXY-5-4 NG_088432.1 WP_004848499.1 extended-spectrum class A beta-lactamase OXY-5-4 blaOXY-5-5 NG_088433.1 WP_109213213.1 extended-spectrum class A beta-lactamase OXY-5-5 blaOXY-5-9 NG_088434.1 WP_182409324.1 extended-spectrum class A beta-lactamase OXY-5-9 blaOXY-6-6 NG_088435.1 WP_049088977.1 extended-spectrum class A beta-lactamase OXY-6-6 blaOXY-6-8 NG_088436.1 WP_154951884.1 extended-spectrum class A beta-lactamase OXY-6-8 blaOXY-6-9 NG_088437.1 WP_155037090.1 extended-spectrum class A beta-lactamase OXY-6-9 blaPDC-528 NG_081798.1 WP_136828312.1 class C beta-lactamase PDC-528 blaPDC-529 NG_081799.1 WP_124129493.1 class C beta-lactamase PDC-529 blaPDC-530 NG_081800.1 WP_257394585.1 class C beta-lactamase PDC-530 blaPDC-531 NG_088438.1 WP_262697184.1 class C beta-lactamase PDC-531 blaPDC-532 NG_088439.1 WP_262697185.1 class C beta-lactamase PDC-532 blaPDC-533 NG_088440.1 WP_262697187.1 class C beta-lactamase PDC-533 blaPEN-A1 NG_088441.1 WP_012216561.1 class A beta-lactamase PEN-A1 blaPEN-A10 NG_088456.1 WP_105846710.1 class A beta-lactamase PEN-A10 blaPEN-A11 NG_088457.1 WP_105777201.1 class A beta-lactamase PEN-A11 blaPEN-A12 NG_088458.1 WP_105809721.1 class A beta-lactamase PEN-A12 blaPEN-A13 NG_088459.1 WP_105766562.1 class A beta-lactamase PEN-A13 blaPEN-A15 NG_088460.1 WP_107999608.1 class A beta-lactamase PEN-A15 blaPEN-A16 NG_088461.1 WP_105825204.1 class A beta-lactamase PEN-A16 blaPEN-A17 NG_088462.1 WP_105951298.1 class A beta-lactamase PEN-A17 blaPEN-A18 NG_088463.1 WP_105835300.1 class A beta-lactamase PEN-A18 blaPEN-A19 NG_088464.1 WP_105791036.1 class A beta-lactamase PEN-A19 blaPEN-A2 NG_088465.1 WP_105796499.1 class A beta-lactamase PEN-A2 blaPEN-A20 NG_088466.1 WP_088926609.1 class A beta-lactamase PEN-A20 blaPEN-A21 NG_088467.1 WP_105841035.1 class A beta-lactamase PEN-A21 blaPEN-A22 NG_088468.1 WP_105842598.1 class A beta-lactamase PEN-A22 blaPEN-A23 NG_088469.1 WP_105782476.1 class A beta-lactamase PEN-A23 blaPEN-A24 NG_088470.1 WP_105813799.1 class A beta-lactamase PEN-A24 blaPEN-A25 NG_088471.1 WP_105854385.1 class A beta-lactamase PEN-A25 blaPEN-A26 NG_088472.1 WP_105765688.1 class A beta-lactamase PEN-A26 blaPEN-A27 NG_088473.1 WP_105765076.1 class A beta-lactamase PEN-A27 blaPEN-A28 NG_088474.1 WP_088924033.1 class A beta-lactamase PEN-A28 blaPEN-A29 NG_088475.1 WP_105792310.1 class A beta-lactamase PEN-A29 blaPEN-A3 NG_088476.1 WP_105769622.1 class A beta-lactamase PEN-A3 blaPEN-A30 NG_088477.1 WP_105807557.1 class A beta-lactamase PEN-A30 blaPEN-A31 NG_088478.1 WP_039217008.1 class A beta-lactamase PEN-A31 blaPEN-A32 NG_088479.1 WP_105762373.1 class A beta-lactamase PEN-A32 blaPEN-A33 NG_088480.1 WP_069220914.1 class A beta-lactamase PEN-A33 blaPEN-A34 NG_088481.1 WP_105856053.1 class A beta-lactamase PEN-A34 blaPEN-A35 NG_088482.1 WP_105795180.1 class A beta-lactamase PEN-A35 blaPEN-A37 NG_088483.1 WP_088929369.1 class A beta-lactamase PEN-A37 blaPEN-A38 NG_088484.1 WP_105837729.1 class A beta-lactamase PEN-A38 blaPEN-A4 NG_088485.1 WP_105781374.1 class A beta-lactamase PEN-A4 blaPEN-A5 NG_088486.1 WP_105822028.1 class A beta-lactamase PEN-A5 blaPEN-A6 NG_088487.1 WP_105803562.1 class A beta-lactamase PEN-A6 blaPEN-A7 NG_088488.1 WP_105758546.1 class A beta-lactamase PEN-A7 blaPEN-A8 NG_088489.1 WP_048804470.1 class A beta-lactamase PEN-A8 blaPEN-A9 NG_088490.1 WP_105772526.1 class A beta-lactamase PEN-A9 blaPEN-B1 NG_088442.1 WP_109342732.1 class A beta-lactamase PEN-B1 blaPEN-B2 NG_088443.1 WP_262697188.1 class A beta-lactamase PEN-B2 blaPEN-B3 NG_088444.1 WP_262697189.1 class A beta-lactamase PEN-B3 blaPEN-B4 NG_088445.1 WP_163122236.1 class A beta-lactamase PEN-B4 blaRAD-1 NG_088446.1 WP_004919358.1 carbapenem-hydrolyzing class D beta-lactamase RAD-1 blaTEM-248 NG_088447.1 WP_262697192.1 class A beta-lactamase TEM-248 blaTEM-249 NG_088448.1 WP_262697193.1 class A beta-lactamase TEM-249 blaVEB-31 NG_088449.1 WP_262697194.1 extended-spectrum class A beta-lactamase VEB-31 blaVIM-82 NG_088450.1 WP_238839790.1 subclass B1 metallo-beta-lactamase VIM-82 blaVIM-83 NG_088451.1 WP_262697195.1 subclass B1 metallo-beta-lactamase VIM-83 mcr-3.42 NG_088452.1 WP_257697591.1 phosphoethanolamine--lipid A transferase MCR-3.42 mcr-4.7 NG_088453.1 WP_223106954.1 phosphoethanolamine--lipid A transferase MCR-4.7 plus VIRULENCE VIRULENCE ctxB AE003852.1 AAF94613.1 cholera enterotoxin binding subunit CtxB ctxA AE003852.1 AAF94614.1 cholera enterotoxin catalytic subunit CtxA Changed reference gene catalog records blaEC-5 AY899338.1 genbank_nucleotide_accession: AY899338.1 -> DQ092424.1 genbank_protein_accession: AAW82909.1 -> AAZ85965.1 genbank_start: 110 -> 185 genbank_stop: 1243 -> 1318 scn ADL23798.1 genbank_nucleotide_accession: CP002114.2 -> CP002114.3 genbank_start: 2037898 -> 2043933 genbank_stop: 2038248 -> 2044283 vanR-Cd AXB64454.1 product_name: VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcriptoin factor VanR-G-Cd vanR-A WP_001280781.1 product_name: VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A vanR-B WP_002317273.1 product_name: VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B vanR-B WP_002368697.1 product_name: VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B vanR-C WP_003126775.1 product_name: VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C blaC WP_003410677.1 gene_family: blaA -> blaC hierarchy_node: blaA_Mtub -> blaC product_name: class A beta-lactamase BlaA -> class A beta-lactamase BlaC vanR-C WP_005228837.1 product_name: VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C blaPEN-bpc WP_006027381.1 gene_family: penI -> blaPEN-bpc hierarchy_node: penI_Bp -> blaPEN-bpc product_name: PenI family extended-spectrum class A beta-lactamase -> PEN family class A beta-lactamase, Bpc-type blaPEN-J WP_010108817.1 gene_family: penI -> blaPEN-J hierarchy_node: penI_Bp -> blaPEN-J product_name: PenI family extended-spectrum class A beta-lactamase -> class A beta-lactamase PEN-J vanR-Sc WP_011029105.1 product_name: VanSc-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-Sc vanR-I WP_011461303.1 product_name: VanI-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-I vanR-D WP_016295750.1 product_name: VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D vanR-G WP_021418928.1 product_name: VanG-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-G vanR-D WP_023042613.1 product_name: VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D vanR-D WP_023043165.1 product_name: VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D blaPEN-L WP_025370306.1 gene_family: penI -> blaPEN-L hierarchy_node: penI_Bp -> blaPEN-L product_name: PenI family extended-spectrum class A beta-lactamase -> class A beta-lactamase PEN-L blaPEN-bcc WP_027789588.1 gene_family: penA -> blaPEN-bcc hierarchy_node: penA-A_Burk -> blaPEN-bcc product_name: PenA family class A beta-lactamase -> PEN family class A beta-lactamase, Bcc-type vanR-B WP_032489743.1 product_name: VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B vanR-C WP_034872470.1 product_name: VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C aadA27 WP_050041693.1 genbank_nucleotide_accession: LN873256.1 -> CP082146.1 genbank_protein_accession: CTQ57092.1 -> UVB02487.1 blaPEN-I WP_063854501.1 gene_family: penI -> blaPEN-I hierarchy_node: penI_Bp -> blaPEN-I product_name: PenI family extended-spectrum class A beta-lactamase -> class A beta-lactamase PEN-I vanR-D WP_063856715.1 product_name: VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D vanR-A WP_063856716.1 product_name: VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A vanR-E WP_063856718.1 product_name: VanE-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-E vanR-B WP_063856719.1 product_name: VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B vanR-A WP_063856720.1 product_name: VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A vanR-A WP_063856721.1 product_name: VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A vanR-D WP_063856722.1 product_name: VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D vanR-B WP_063856723.1 product_name: VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B vanR-L WP_063856724.1 product_name: VanL-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-L vanR-C WP_063856725.1 product_name: VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C vanR-D WP_063856727.1 product_name: VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D vanR-N WP_063856728.1 product_name: VanN-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-N vanR-O WP_063856729.1 product_name: VanO-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-O blaKPC-44 WP_140423311.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-44 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-44 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-86 WP_213994592.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-86 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-86 pubmed_reference: -> 36003991 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-87 WP_213994593.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-87 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-87 pubmed_reference: -> 36003991 blaKPC-88 WP_213994594.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-88 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-88 pubmed_reference: -> 36003991 subclass: CARBAPENEM -> CEPHALOSPORIN blaPAM-2 WP_173179784.1 pubmed_reference: 33577996 -> 33577996,35786775 Hierarchy nodes added core AMR AMR aac(6')-Iap aac(6')-Iap aminoglycoside 6'-N-acetyltransferase AAC(6')-Iap blaC blaC NF041154.1 class A beta-lactamase BlaC blaKBL blaKBL NF041189.1 KBL family class A beta-lactamase blaMAB blaMAB NF041113.1 MAB family class A beta-lactamase blaOXY-10 blaOXY OXY-10 family extended-spectrum class A beta-lactamase blaPEN blaPEN PEN family class A beta-lactamase blaPEN-A blaPEN-A NF041143.1 PEN-A family class A beta-lactamase blaPEN-B blaPEN-B NF041138.1 PEN-B family class A beta-lactamase blaPEN-E blaPEN-E PEN-E family class A beta-lactamase blaPEN-F blaPEN-F PEN-F family class A beta-lactamase blaPEN-I blaPEN-I class A beta-lactamase PEN-I blaPEN-J blaPEN-J class A beta-lactamase PEN-J blaPEN-L blaPEN-L class A beta-lactamase PEN-L blaPEN-bcc blaPEN-bcc NF000320.3 PEN family class A beta-lactamase, Bcc-type blaPEN-bpc blaPEN-bpc NF000321.3 PEN family class A beta-lactamase, Bpc-type blaRAD blaRAD NF041187.1 RAD family carbapenem-hydrolyzing class D beta-lactamase vanH-P vanH-P D-lactate dehydrogenase VanH-P vanR-P vanR-P vancomycin resistance response regulator transcription factor VanR-P vanX-P vanX-P D-Ala-D-Ala dipeptidase VanX-P non-reported VIRULENCE VIRULENCE VIRULENCE_Vchol plus VIRULENCE VIRULENCE ctxA ctxA cholera enterotoxin catalytic subunit CtxA ctxB ctxB cholera enterotoxin binding subunit CtxB Hierarchy nodes removed core AMR AMR blaA_Mtub blaA class A beta-lactamase BlaA penA-A_Burk penA NF000320.2 PenA family class A beta-lactamase penI_Bp penI NF000321.2 PenI family extended-spectrum class A beta-lactamase Changed Hierarchy Nodes blaEBR EBR family subclass B1 metallo-beta-lactamase hmm_acc: NF000444.2 -> NF000444.3 blaGIM GIM family subclass B1 metallo-beta-lactamase hmm_acc: NF000396.2 -> NF000396.3 blaHMB HMB family subclass B1 metallo-beta-lactamase hmm_acc: -> NF041161.1 blaSPR SPR family subclass B3 metallo-beta-lactamase name: SPR family putative metallo-beta-lactamase -> SPR family subclass B3 metallo-beta-lactamase mcr-3_set MCR-3-related phosphoethanolamine--lipid A transferase name: MCR-3 family phosphoethanolamine--lipid A transferase -> MCR-3-related phosphoethanolamine--lipid A transferase vanR-A vancomycin resistance response regulator transcription factor VanR-A name: VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A vanR-B vancomycin resistance response regulator transcription factor VanR-B name: VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B vanR-C vancomycin resistance response regulator transcription factor VanR-C name: VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C vanR-Cd vancomycin resistance response regulator transcriptoin factor VanR-G-Cd name: VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcriptoin factor VanR-G-Cd vanR-D vancomycin resistance response regulator transcription factor VanR-D name: VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D vanR-E vancomycin resistance response regulator transcription factor VanR-E name: VanE-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-E vanR-FM vancomycin resistance response regulator transcription factor VanR-FM name: VanR-FM family response regulator transcription factor -> vancomycin resistance response regulator transcription factor VanR-FM vanR-G vancomycin resistance response regulator transcription factor VanR-G name: VanG-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-G vanR-I vancomycin resistance response regulator transcription factor VanR-I name: VanI-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-I vanR-L vancomycin resistance response regulator transcription factor VanR-L name: VanL-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-L vanR-N vancomycin resistance response regulator transcription factor VanR-N name: VanN-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-N vanR-O vancomycin resistance response regulator transcription factor VanR-O name: VanO-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-O vanR-Sc vancomycin resistance response regulator transcription factor VanR-Sc name: VanSc-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-Sc ---------------------------------------------------------------------- Changes included in 2022-08-09.1 ---------------------------------------------------------------------- Overview: - Curators reviewed and added point mutations for new organisms Burkholderia cepacia complex and Burkholderia pseudomallei complex - New point mutations for Neisseria, E. coli, Campylobacter, and Acinetobacter. - Several new hierarchy nodes for new families and new subfamilies including two new beta-lactamase families and two new erm families. - Several new blaOXY genes and families stemming from a review of blaOXY nomenclature hosted at the Pasteur Institute. - Several new beta-lacatamase HMMs for small beta-lactamase families. - Additional PubMed references for some point mutations reexamined by curators. This led to changes in class and subclass for some parE and ompF mutations. Summary: Total proteins: 7374 Core proteins: 6286 Plus proteins: 1087 AMR proteins: 6333 STRESS proteins: 235 VIRULENCE proteins: 806 PubMed references: 2586 Point mutations: 991 Point mutation reference sequences: 173 Point mutation organism groups: Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei, Campylobacter, Clostridioides_difficile, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 674 Updates since release 2022-05-26.1: Proteins added: 115 Core proteins added: 115 Plus proteins added: 0 AMR proteins added: 115 Alleles added: 108 PubMed references added: 78 Point mutations added: 49 Reference Gene Catalog entries changed: 18 Hierarchy nodes added: 13 Hierarchy nodes changed: 5 Added proteins core AMR AMR erm(54) NG_081669.1 WP_031885508.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(54) lnu(H) NG_081670.1 WP_051021433.1 lincosamide nucleotidyltransferase Lnu(H) mef(H) NG_081672.1 WP_070509550.1 macrolide efflux MFS transporter Mef(H) poxtA-Ef NG_081674.1 WP_094899500.1 ABC-F type ribosomal protection protein PoxtA-Ef erm(53) NG_081668.1 WP_139847607.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(53) mef(J) NG_081673.1 WP_198462968.1 macrolide efflux MFS transporter Mef(J) blaACT-109 NG_081676.1 WP_063157039.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-109 blaADC-267 NG_081677.1 WP_256875591.1 extended-spectrum class C beta-lactamase ADC-267 blaADC-268 NG_081678.1 WP_105922788.1 extended-spectrum class C beta-lactamase ADC-268 blaADC-269 NG_081679.1 WP_032025626.1 extended-spectrum class C beta-lactamase ADC-269 blaADC-270 NG_081680.1 WP_199947622.1 extended-spectrum class C beta-lactamase ADC-270 blaADC-271 NG_081681.1 WP_247791718.1 extended-spectrum class C beta-lactamase ADC-271 blaADC-272 NG_081682.1 WP_256875592.1 extended-spectrum class C beta-lactamase ADC-272 blaADC-273 NG_081683.1 WP_256875593.1 extended-spectrum class C beta-lactamase ADC-273 blaADC-274 NG_081684.1 WP_256875594.1 extended-spectrum class C beta-lactamase ADC-274 blaADC-275 NG_081685.1 WP_256875595.1 extended-spectrum class C beta-lactamase ADC-275 blaADC-276 NG_081686.1 WP_256875596.1 extended-spectrum class C beta-lactamase ADC-276 blaADC-277 NG_081687.1 WP_256875597.1 extended-spectrum class C beta-lactamase ADC-277 blaADC-278 NG_081688.1 WP_118978092.1 extended-spectrum class C beta-lactamase ADC-278 blaADC-279 NG_081689.1 WP_038343177.1 extended-spectrum class C beta-lactamase ADC-279 blaADC-280 NG_081690.1 WP_078202643.1 extended-spectrum class C beta-lactamase ADC-280 blaADC-281 NG_081691.1 WP_256875598.1 extended-spectrum class C beta-lactamase ADC-281 blaADC-282 NG_081692.1 WP_256875599.1 extended-spectrum class C beta-lactamase ADC-282 blaCMY-178 NG_081693.1 WP_256875600.1 class C beta-lactamase CMY-178 blaCMY-181 NG_081780.1 WP_134216345.1 class C beta-lactamase CMY-181 blaCTX-M-253 NG_081694.1 WP_256875601.1 extended-spectrum class A beta-lactamase CTX-M-253 blaCTX-M-254 NG_081695.1 WP_256875602.1 extended-spectrum class A beta-lactamase CTX-M-254 blaCTX-M-255 NG_081696.1 WP_254205601.1 extended-spectrum class A beta-lactamase CTX-M-255 blaCTX-M-256 NG_081781.1 WP_257102135.1 extended-spectrum class A beta-lactamase CTX-M-256 blaFONA-7 NG_081697.1 WP_098931096.1 class A beta-lactamase FONA-7 blaGES-54 NG_081003.1 WP_250115625.1 carbapenem-hydrolyzing class A beta-lactamase GES-54 blaGES-55 NG_081782.1 WP_257102136.1 class A beta-lactamase GES-55 blaGOB-53 NG_081698.1 WP_256875603.1 subclass B3 metallo-beta-lactamase GOB-53 blaKPC-100 NG_081070.1 WP_250200322.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-100 blaKPC-127 NG_081071.1 WP_250200323.1 carbapenem-hydrolyzing class A beta-lactamase KPC-127 blaKPC-128 NG_081072.1 WP_250200324.1 carbapenem-hydrolyzing class A beta-lactamase KPC-128 blaKPC-130 NG_081699.1 WP_253892094.1 class A beta-lactamase KPC-130 blaKPC-131 NG_081700.1 WP_256875604.1 carbapenem-hydrolyzing class A beta-lactamase KPC-131 blaKPC-132 NG_081783.1 WP_257102137.1 inhibitor-resistant class A beta-lactamase KPC-132 blaKPC-133 NG_081784.1 WP_257102138.1 carbapenem-hydrolyzing class A beta-lactamase KPC-133 blaNDM-43 NG_081701.1 WP_256875605.1 subclass B1 metallo-beta-lactamase NDM-43 blaNWM-1 NG_081702.1 WP_256875606.1 subclass B3 metallo-beta-lactamase NWM-1 blaOXA-1052 NG_081703.1 WP_256875607.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1052 blaOXA-1087 NG_081704.1 WP_256875608.1 OXA-10 family class D beta-lactamase OXA-1087 blaOXA-1119 NG_081705.1 WP_256875609.1 OXA-48 family class D beta-lactamase OXA-1119 blaOXA-1120 NG_081706.1 WP_256875610.1 OXA-10 family class D beta-lactamase OXA-1120 blaOXA-1121 NG_081707.1 WP_256875611.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1121 blaOXA-1122 NG_081708.1 WP_256875612.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1122 blaOXA-1123 NG_081709.1 WP_256875613.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1123 blaOXA-1124 NG_081710.1 WP_124125861.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1124 blaOXA-1125 NG_081711.1 WP_033955867.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1125 blaOXA-1126 NG_081712.1 WP_256875614.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1126 blaOXA-1127 NG_081713.1 WP_023122435.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1127 blaOXA-1128 NG_081714.1 WP_256875615.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1128 blaOXA-1129 NG_081715.1 WP_057387633.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1129 blaOXA-1130 NG_081716.1 WP_256875616.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1130 blaOXA-1131 NG_081717.1 WP_126622689.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1131 blaOXA-1132 NG_081718.1 WP_058017838.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1132 blaOXA-1133 NG_081719.1 WP_033968246.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1133 blaOXA-1134 NG_081720.1 WP_256875617.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1134 blaOXA-1135 NG_081721.1 WP_033978625.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1135 blaOXA-1136 NG_081722.1 WP_256875618.1 OXA-2 family class D beta-lactamase OXA-1136 blaOXA-1137 NG_081723.1 WP_256875619.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1137 blaOXA-1138 NG_081724.1 WP_256875620.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1138 blaOXA-1139 NG_081725.1 WP_256875621.1 OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-1139 blaOXA-944 NG_081726.1 WP_256875622.1 OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-944 blaOXY-1-11 NG_081727.1 WP_049082137.1 extended-spectrum class A beta-lactamase OXY-1-11 blaOXY-1-12 NG_081728.1 WP_057174064.1 extended-spectrum class A beta-lactamase OXY-1-12 blaOXY-1-13 NG_081729.1 WP_080528555.1 extended-spectrum class A beta-lactamase OXY-1-13 blaOXY-1-17 NG_081730.1 WP_162121893.1 extended-spectrum class A beta-lactamase OXY-1-17 blaOXY-1-18 NG_081731.1 WP_185219566.1 extended-spectrum class A beta-lactamase OXY-1-18 blaOXY-11-1 NG_081732.1 WP_154679523.1 extended-spectrum class A beta-lactamase OXY-11-1 blaOXY-12-1 NG_081733.1 WP_181483194.1 extended-spectrum class A beta-lactamase OXY-12-1 blaOXY-2-17 NG_081734.1 WP_256875623.1 extended-spectrum class A beta-lactamase OXY-2-17 blaOXY-2-18 NG_081735.1 WP_064396914.1 extended-spectrum class A beta-lactamase OXY-2-18 blaOXY-2-19 NG_081736.1 WP_256875624.1 extended-spectrum class A beta-lactamase OXY-2-19 blaOXY-2-21 NG_081737.1 WP_049127974.1 extended-spectrum class A beta-lactamase OXY-2-21 blaOXY-2-22 NG_081738.1 WP_064344965.1 extended-spectrum class A beta-lactamase OXY-2-22 blaOXY-2-23 NG_081739.1 WP_064361275.1 extended-spectrum class A beta-lactamase OXY-2-23 blaOXY-2-24 NG_081740.1 WP_064375196.1 extended-spectrum class A beta-lactamase OXY-2-24 blaOXY-2-26 NG_081741.1 WP_126488681.1 extended-spectrum class A beta-lactamase OXY-2-26 blaOXY-2-28 NG_081742.1 WP_256875625.1 extended-spectrum class A beta-lactamase OXY-2-28 blaOXY-2-30 NG_081743.1 WP_241700785.1 extended-spectrum class A beta-lactamase OXY-2-30 blaOXY-3-2 NG_081744.1 WP_142464024.1 extended-spectrum class A beta-lactamase OXY-3-2 blaOXY-3-3 NG_081745.1 WP_142981135.1 extended-spectrum class A beta-lactamase OXY-3-3 blaOXY-4-2 NG_081746.1 WP_142446236.1 extended-spectrum class A beta-lactamase OXY-4-2 blaOXY-4-3 NG_081747.1 WP_142467842.1 extended-spectrum class A beta-lactamase OXY-4-3 blaOXY-4-4 NG_081748.1 WP_142471056.1 extended-spectrum class A beta-lactamase OXY-4-4 blaOXY-4-5 NG_081749.1 WP_142481206.1 extended-spectrum class A beta-lactamase OXY-4-5 blaOXY-5-11 NG_081750.1 WP_197663517.1 extended-spectrum class A beta-lactamase OXY-5-11 blaOXY-5-6 NG_081751.1 WP_177340503.1 extended-spectrum class A beta-lactamase OXY-5-6 blaOXY-5-7 NG_081752.1 WP_181251167.1 extended-spectrum class A beta-lactamase OXY-5-7 blaOXY-5-8 NG_081753.1 WP_182012076.1 extended-spectrum class A beta-lactamase OXY-5-8 blaOXY-6-10 NG_081754.1 WP_181246811.1 extended-spectrum class A beta-lactamase OXY-6-10 blaOXY-6-11 NG_081755.1 WP_181511480.1 extended-spectrum class A beta-lactamase OXY-6-11 blaOXY-6-5 NG_081756.1 WP_024358907.1 extended-spectrum class A beta-lactamase OXY-6-5 blaOXY-6-7 NG_081757.1 WP_098066351.1 extended-spectrum class A beta-lactamase OXY-6-7 blaOXY-7-1 NG_081758.1 WP_256875626.1 extended-spectrum class A beta-lactamase OXY-7-1 blaOXY-8-1 NG_081759.1 WP_112215366.1 extended-spectrum class A beta-lactamase OXY-8-1 blaOXY-8-2 NG_081760.1 WP_142515482.1 extended-spectrum class A beta-lactamase OXY-8-2 blaOXY-8-3 NG_081761.1 WP_142512117.1 extended-spectrum class A beta-lactamase OXY-8-3 blaOXY-9-1 NG_081762.1 WP_142465578.1 extended-spectrum class A beta-lactamase OXY-9-1 blaPAM-3 NG_081763.1 WP_111263186.1 subclass B3 metallo-beta-lactamase PAM-3 blaPDC-519 NG_081764.1 WP_256875627.1 class C beta-lactamase PDC-519 blaPDC-520 NG_081765.1 WP_256875628.1 class C beta-lactamase PDC-520 blaPDC-521 NG_081766.1 WP_256875629.1 class C beta-lactamase PDC-521 blaPDC-522 NG_081767.1 WP_256875630.1 class C beta-lactamase PDC-522 blaPDC-523 NG_081768.1 WP_256875631.1 class C beta-lactamase PDC-523 blaPDC-524 NG_081769.1 WP_256875632.1 class C beta-lactamase PDC-524 blaPDC-525 NG_081770.1 WP_256875633.1 class C beta-lactamase PDC-525 blaPDC-526 NG_081771.1 WP_121128759.1 class C beta-lactamase PDC-526 blaPDC-527 NG_081772.1 WP_256875634.1 class C beta-lactamase PDC-527 blaSIE-1 NG_081773.1 WP_007683232.1 subclass B3 metallo-beta-lactamase SIE-1 blaTEM-247 NG_081774.1 WP_256875635.1 class A beta-lactamase TEM-247 core AMR AMR-SUSCEPTIBLE pbp2 WP_003703066.1 Neisseria penicillin-binding protein PBP2 Added point mutations core AMR POINT adeL_G27R TIGECYCLINE Acinetobacter_baumannii adeS_F12S TIGECYCLINE Acinetobacter_baumannii ampD_A18E CEPHALOSPORIN Burkholderia_cepacia ampD_F191C CEPHALOSPORIN Burkholderia_cepacia ampD_H68Y CEPHALOSPORIN Burkholderia_cepacia ampD_H74P CEPHALOSPORIN Burkholderia_cepacia ampD_I121S CEPHALOSPORIN Burkholderia_cepacia ampD_L37F CEPHALOSPORIN Burkholderia_cepacia ampD_L63P CEPHALOSPORIN Burkholderia_cepacia ampD_L75P CEPHALOSPORIN Burkholderia_cepacia ampD_P46T CEPHALOSPORIN Burkholderia_cepacia ampD_R167S CEPHALOSPORIN Burkholderia_cepacia ampD_R79G CEPHALOSPORIN Burkholderia_cepacia ampD_S120L CEPHALOSPORIN Burkholderia_cepacia ampD_S44G CEPHALOSPORIN Burkholderia_cepacia ampD_S81P CEPHALOSPORIN Burkholderia_cepacia ampD_V39A CEPHALOSPORIN Burkholderia_cepacia amrR_A47T CARBAPENEM Burkholderia_pseudomallei amrR_ASLD153del CARBAPENEM Burkholderia_pseudomallei amrR_E190STOP CARBAPENEM Burkholderia_pseudomallei amrR_E21D CARBAPENEM Burkholderia_pseudomallei amrR_G30D CARBAPENEM Burkholderia_pseudomallei amrR_L132P CARBAPENEM Burkholderia_pseudomallei amrR_L142P AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN Burkholderia_cepacia amrR_S166P CARBAPENEM Burkholderia_pseudomallei amrR_S174P CHLORAMPHENICOL/MEROPENEM/QUINOLONE Burkholderia_cepacia amrR_VAVC60del CARBAPENEM Burkholderia_pseudomallei bpeR_D176A CARBAPENEM Burkholderia_pseudomallei dut_G91A TRIMETHOPRIM-SULFAMETHOXAZOLE Burkholderia_pseudomallei gyrA_D87H QUINOLONE Burkholderia_cepacia gyrA_D87Y QUINOLONE Burkholderia_pseudomallei gyrA_D95N QUINOLONE Neisseria gyrA_G81C QUINOLONE Burkholderia_pseudomallei gyrA_G81D QUINOLONE Burkholderia_cepacia gyrA_T173A QUINOLONE Neisseria gyrA_T83I QUINOLONE Burkholderia_pseudomallei gyrA_T83I QUINOLONE Burkholderia_cepacia gyrA_T91I QUINOLONE Neisseria gyrA_Y77S QUINOLONE Burkholderia_pseudomallei ompK36_D135DD CARBAPENEM Klebsiella ompR_G63S BETA-LACTAM Escherichia ompR_G63V BETA-LACTAM Escherichia rpoB_D543V RIFAMPIN Neisseria rpoB_H553N RIFAMPIN Neisseria rpoB_H553R RIFAMPIN Neisseria rpoB_H553Y RIFAMPIN Neisseria rpoB_S549F RIFAMPIN Neisseria rpoB_S558F RIFAMPIN Neisseria yciV_DALAALG107del TRIMETHOPRIM-SULFAMETHOXAZOLE Burkholderia_pseudomallei Changed reference gene catalog records armA WP_000359986.1 product_name: ArmA family 16S rRNA (guanine(1405)-N(7))-methyltransferase -> 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA blaKPC-41 WP_148044419.1 product_name: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-41 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-41 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-50 WP_171476788.1 product_name: inhibitor-resistant class A beta-lactamase KPC-50 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-50 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-53 WP_156649232.1 pubmed_reference: 33106265 -> 33106265,35647648 gyrA_D95N WP_003688895.1 pubmed_reference: 7830580 -> 10799008,7830580 gyrA_P104S WP_002779062.1 pubmed_reference: -> 12493783,12121947,15078520,16553723 gyrA_P104S WP_002857904.1 pubmed_reference: -> 12493783,12121947,15078520,16553723 gyrA_T86I WP_002779062.1 pubmed_reference: -> 12493783,12121947,15078520,16553723 gyrA_T86I WP_002857904.1 pubmed_reference: -> 12493783,12121947,15078520,16553723 ompF_G141D WP_000977920.1 class: FOSFOMYCIN -> BETA-LACTAM pubmed_reference: -> 28072422,10639355 subclass: FOSFOMYCIN -> CEPHALOSPORIN ompF_G141E WP_000977920.1 class: FOSFOMYCIN -> BETA-LACTAM pubmed_reference: -> 10639355 subclass: FOSFOMYCIN -> CEPHALOSPORIN ompK36_T136TDT WP_002913005.1 pubmed_reference: 30875398,31477712 -> 30875398,31477712,35816554 parE_D432H WP_001837315.1 class: AMINOCOUMARIN -> QUINOLONE pubmed_reference: -> 21996946 subclass: AMINOCOUMARIN -> QUINOLONE parE_D432N WP_001837315.1 class: AMINOCOUMARIN -> QUINOLONE pubmed_reference: -> 21996946 subclass: AMINOCOUMARIN -> QUINOLONE parE_G78S WP_001837315.1 class: QUINOLONE -> AMINOCOUMARIN subclass: QUINOLONE -> AMINOCOUMARIN parE_N470S WP_001837315.1 class: AMINOCOUMARIN -> QUINOLONE subclass: AMINOCOUMARIN -> QUINOLONE parE_P585S WP_001837315.1 class: AMINOCOUMARIN -> QUINOLONE pubmed_reference: -> 21996946 subclass: AMINOCOUMARIN -> QUINOLONE parE_R136G WP_001837315.1 class: QUINOLONE -> AMINOCOUMARIN subclass: QUINOLONE -> AMINOCOUMARIN Hierarchy nodes added core AMR AMR blaNWM blaNWM NWM family subclass B3 metallo-beta-lactamase blaOXY-11 blaOXY OXY-11 family extended-spectrum class A beta-lactamase blaOXY-12 blaOXY OXY-12 family extended-spectrum class A beta-lactamase blaOXY-7 blaOXY OXY-7 family extended-spectrum class A beta-lactamase blaOXY-8 blaOXY OXY-8 family extended-spectrum class A beta-lactamase blaOXY-9 blaOXY OXY-9 family extended-spectrum class A beta-lactamase blaSIE blaSIE SIE family subclass B3 metallo-beta-lactamase erm(53) erm(53) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(53) erm(54) erm(54) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(54) lnu(H) lnu(H) NF040958.1 lincosamide nucleotidyltransferase Lnu(H) mef(H) mef(H) macrolide efflux MFS transporter Mef(H) mef(J) mef(J) macrolide efflux MFS transporter Mef(J) poxtA-Ef poxtA-Ef ABC-F type ribosomal protection protein PoxtA-Ef Hierarchy nodes removed Changed Hierarchy Nodes armA 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA name: ArmA family 16S rRNA (guanine(1405)-N(7))-methyltransferase -> 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA blaHBL HBL family class A beta-lactamase hmm_acc: -> NF040780.1 blaHER HER family class A beta-lactamase hmm_acc: -> NF040940.1 blaRAHN RAHN family extended-spectrum class A beta-lactamase hmm_acc: -> NF040934.1 name: RAHN family class A beta-lactamase -> RAHN family extended-spectrum class A beta-lactamase blaWUS WUS family subclass B1 metallo-beta-lactamase hmm_acc: -> NF040860.1 ---------------------------------------------------------------------- Changes included in 2022-05-26.1 ---------------------------------------------------------------------- Overview: - NCBI has changed two allele numbers for two rare alleles in the blaROB family, in order to make database numbering match the tentative usage in Kadlec, et al. (2019) (PMID:30561662). The protein AGH37381.1, previously called blaROB-2, has a new designation, blaROB-13. AWU47610.1, which had been blaROB-9, is now blaROB-2, which is interesting because so far it is the only extended-spectrum in the family. The designation blaROB-9 will not be used anymore. - Adjective placement in English is hard. In order to make the the adjective placement and order in beta-lactamase product names uniform and consistent a bulk change was made to move substrate-specificity-describing-adjectives in front of the class description. For example to change "class C extended-spectrum beta-lactamase PDC-4" to "extended-spectrum class C beta-lactamase PDC-4". The descriptors that may have moved include carbapenem-hydrolyzing, cefepime-hydrolyzing, oxicillin-hydrolying, extended-spectrum, and broad-spectrum. This was not a change to the descriptions or specificity, but just the order of the words in the names so that they will all be uniform and consistent. - The previous class and subclass of poxtA were incorrect and were changed to reflect their correct resistance phenotypes. - Recently added Reference Gene Catalog point mutation fields for refseq_start, refseq_stop, refseq_strand, and curated_refseq_start were previously filled in for all point mutations, including those with no RefSeq nucleotide (the numbers were copied from GenBank coordinates). The fields have been emptied where there is no RefSeq accession. - Continued review of blaOXA alleles led to improved specificity of subclasses for many blaOXA alleles and some families see the Reference Gene Hierarchy for specifics on family structure: https://www.ncbi.nlm.nih.gov/pathogens/genehierarchy - Many pubmed references added to alleles and families to point to papers with more specific characterization - Review of literature and increased specificity for subclasses of many blaSHV, blaKPC, blaGES alleles - Moved a few blaEC alleles from 'core' to 'plus' on the basis of published characterization (pmid: 16801449) - Proteins names have been revised for blaADC beta-lactamases. As these enzymes readily hydrolyze at least one 3rd generation cephalosporin, any allele '#' is now named "extended-spectrum class C beta-lactamase ADC-#" except in two cases. If the enzyme cleaves cefepime, a fourth-generation cephalosporin, it is named "cefepime-hydrolyzing class C beta-lactamase ADC-#". If it cleaves any carbapenem, it is named "carbapenem-hydrolyzing class C beta-lactamase ADC-#". Summary: Total proteins: 7259 Core proteins: 6171 Plus proteins: 1087 AMR proteins: 6218 STRESS proteins: 235 VIRULENCE proteins: 806 PubMed references: 2508 Point mutations: 942 Point mutation reference sequences: 161 Point mutation organism groups: Acinetobacter_baumannii, Campylobacter, Clostridioides_difficile, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 669 Updates since release 2022-04-04.1: Proteins added: 33 Core proteins added: 29 Plus proteins added: 4 AMR proteins added: 31 STRESS proteins added: 1 VIRULENCE proteins added: 1 Alleles added: 26 PubMed references added: 146 PubMed references removed: 1 Point mutations added: 3 Proteins removed: 3 Core proteins removed: 2 Plus proteins removed: 1 Reference Gene Catalog entries changed: 1172 Hierarchy nodes added: 7 Hierarchy nodes changed: 41 Added proteins core AMR AMR fexB NG_080766.1 WP_002415211.1 chloramphenicol/florfenicol efflux MFS transporter FexB erm(52) NG_080765.1 WP_002571018.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(52) erm(51) NG_080764.1 WP_131386768.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(51) erm(50) NG_080763.1 WP_176453837.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50) mef(F) NG_080767.1 WP_188020219.1 macrolide efflux MFS transporter Mef(F) blaACT-108 NG_080768.1 WP_126297136.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-108 blaACT-GC1 NG_080769.1 WP_249828058.1 extended spectrum class C beta-lactamase ACT-GC1 blaADC-266 NG_080770.1 WP_249828059.1 extended-spectrum class C beta-lactamase ADC-266 blaCMY-180 NG_080771.1 WP_060855400.1 class C beta-lactamase CMY-180 blaGES-52 NG_080772.1 WP_249828060.1 extended-spectrum class A beta-lactamase GES-52 blaGES-53 NG_080773.1 WP_249828061.1 carbapenem-hydrolyzing class A beta-lactamase GES-53 blaGMA-1 NG_080774.1 WP_012774820.1 GMA family class A beta-lactamase GMA-1 blaGMA-2 NG_080775.1 WP_150896653.1 GMA family class A beta-lactamase GMA-2 blaIMP-96 NG_080776.1 WP_186931965.1 subclass B1 metallo-beta-lactamase IMP-96 blaKLUG-1 NG_080777.1 WP_249828062.1 CTX-M family extended-spectrum class A beta-lactamase KLUG-1 blaKPC-125 NG_080778.1 WP_248496376.1 carbapenem-hydrolyzing class A beta-lactamase KPC-125 blaKPC-126 NG_080779.1 WP_249828063.1 carbapenem-hydrolyzing class A beta-lactamase KPC-126 blaKPC-93 NG_080780.1 WP_243939160.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-93 blaNDM-33 NG_080782.1 WP_224452742.1 subclass B1 metallo-beta-lactamase NDM-33 blaNDM-42 NG_080783.1 WP_249828064.1 subclass B1 metallo-beta-lactamase NDM-42 blaOXA-1108 NG_080784.1 WP_237920325.1 class D beta-lactamase OXA-1108 blaOXA-1117 NG_080785.1 WP_249828065.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1117 blaOXA-1118 NG_080786.1 WP_249828066.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1118 blaPDC-517 NG_080787.1 WP_249828067.1 class C beta-lactamase PDC-517 blaPDC-518 NG_080788.1 WP_249828068.1 class C beta-lactamase PDC-518 blaPJM-1 NG_080789.1 WP_213603971.1 subclass B3 metallo-beta-lactamase PJM-1 blaSRT-4 NG_080790.1 WP_249828069.1 class C beta-lactamase SRT-4 blaWUS-1 NG_080791.1 WP_249828070.1 subclass B1 metallo-beta-lactamase WUS-1 fosA7.9 NG_080792.1 WP_071684814.1 fosfomycin resistance glutathione transferase FosA7.9 plus AMR AMR blaEC-5 AY899338.1 AAW82909.1 cephalosporin-hydrolyzing class C beta-lactamase EC-5 blaEC-8 DQ092427.1 AAZ85968.1 cephalosporin-hydrolyzing class C beta-lactamase EC-8 plus STRESS METAL arsR AAXDBA010000092.1 EGO5141043.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR plus VIRULENCE VIRULENCE tccP WP_071805594.1 Tir-cytoskeleton coupling protein TccP Added point mutations core AMR POINT acrB_R717L AZITHROMYCIN/CLARITHROMYCIN/ERYTHROMYCIN Escherichia acrB_R717Q AZITHROMYCIN/CLARITHROMYCIN/ERYTHROMYCIN Escherichia pmrB_D313N COLISTIN Klebsiella Removed proteins core AMR AMR blaEC-5 NG_049085.1 WP_001443153.1 cephalosporin-hydrolyzing class C beta-lactamase EC-5 blaEC-8 NG_049086.1 WP_063860454.1 cephalosporin-hydrolyzing class C beta-lactamase EC-8 plus STRESS METAL arsR CM001159.1 EGJ25781.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR Changed reference gene catalog records pbp2x WP_000872264.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X59 pbp2x WP_000872267.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X2 pbp2x WP_000872270.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X4 pbp2x WP_000872271.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X0 pbp2x WP_000872273.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X10 pbp2x WP_000872275.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X3 pbp2x WP_000872277.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X6 pbp2x WP_000872282.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X5 pbp1a WP_001039998.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A1 pbp1a WP_001040004.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A3 pbp1a WP_001040010.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A2 pbp1a WP_001040013.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A0 pbp2b WP_001224867.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B0 pbp2b WP_001224871.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B3 pbp2b WP_001224884.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B2 pbp2b WP_001224885.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B6 pbp2b WP_001224886.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B4 poxtA WP_002415638.1 class: MACROLIDE -> PHENICOL/OXAZOLIDINONE subclass: MACROLIDE -> CHLORAMPHENICOL/FLORFENICOL/LINEZOLID cfxA WP_004339683.1 product_name: CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase cfxA3 WP_004348227.1 product_name: class A extended-spectrum beta-lactamase CfxA3 -> extended-spectrum class A beta-lactamase CfxA3 cepA WP_005795628.1 product_name: CepA family class A extended-spectrum beta-lactamase -> CepA family extended-spectrum class A beta-lactamase cepA WP_005816369.1 product_name: CepA family class A extended-spectrum beta-lactamase -> CepA family extended-spectrum class A beta-lactamase penI WP_006027381.1 product_name: PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase penI WP_010108817.1 product_name: PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase cepA WP_010992371.1 product_name: CepA family class A extended-spectrum beta-lactamase -> CepA family extended-spectrum class A beta-lactamase penI WP_025370306.1 product_name: PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase cfxA5 WP_032946415.1 product_name: class A broad-spectrum beta-lactamase CfxA5 -> broad-spectrum class A beta-lactamase CfxA5 pbp2x WP_033707918.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X23 pbp1a WP_050078510.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A11 pbp1a WP_050208712.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A12 pbp2x WP_050293540.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X27 pbp2x WP_054364452.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X12 pbp1a WP_054370471.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A9 cfxA4 WP_057280848.1 product_name: class A extended-spectrum beta-lactamase CfxA4 -> extended-spectrum class A beta-lactamase CfxA4 pbp2b WP_061634854.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B5 pbp2x WP_061745305.1 product_name: Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X17 blaOCH WP_063842730.1 product_name: OCH family class C extended-spectrum beta-lactamase -> OCH family extended-spectrum class C beta-lactamase blaOKP-B WP_063842745.1 product_name: OKP-B family class A broad-spectrum beta-lactamase -> OKP-B family broad-spectrum class A beta-lactamase cfxA WP_063843237.1 product_name: class A broad-spectrum beta-lactamase CfxA -> broad-spectrum class A beta-lactamase CfxA cfxA WP_063843238.1 product_name: CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase cfxA WP_063843239.1 product_name: CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase cfxA WP_063843240.1 product_name: CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase cfxA WP_063843241.1 product_name: CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase cfxA2 WP_063843242.1 product_name: class A extended-spectrum beta-lactamase CfxA2 -> extended-spectrum class A beta-lactamase CfxA2 cfxA2 WP_063843243.1 product_name: class A extended-spectrum beta-lactamase CfxA2 -> extended-spectrum class A beta-lactamase CfxA2 penI WP_063854501.1 product_name: PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase cfxA6 WP_117664257.1 product_name: class A broad-spectrum beta-lactamase CfxA6 -> broad-spectrum class A beta-lactamase CfxA6 blaACI-1 WP_006555379.1 product_name: class A extended-spectrum beta-lactamase ACI-1 -> extended-spectrum class A beta-lactamase ACI-1 blaADC-1 WP_004714775.1 product_name: class C extended-spectrum beta-lactamase ADC-1 -> extended-spectrum class C beta-lactamase ADC-1 blaADC-10 WP_063857786.1 product_name: class C extended-spectrum beta-lactamase ADC-10 -> extended-spectrum class C beta-lactamase ADC-10 blaADC-100 WP_068981607.1 product_name: class C beta-lactamase ADC-100 -> extended-spectrum class C beta-lactamase ADC-100 blaADC-101 WP_068981608.1 product_name: class C beta-lactamase ADC-101 -> extended-spectrum class C beta-lactamase ADC-101 blaADC-102 WP_068981609.1 product_name: class C beta-lactamase ADC-102 -> extended-spectrum class C beta-lactamase ADC-102 blaADC-103 WP_068981610.1 product_name: class C beta-lactamase ADC-103 -> extended-spectrum class C beta-lactamase ADC-103 blaADC-104 WP_068981611.1 product_name: class C beta-lactamase ADC-104 -> extended-spectrum class C beta-lactamase ADC-104 blaADC-105 WP_068981612.1 product_name: class C beta-lactamase ADC-105 -> extended-spectrum class C beta-lactamase ADC-105 blaADC-106 WP_068981613.1 product_name: class C beta-lactamase ADC-106 -> extended-spectrum class C beta-lactamase ADC-106 blaADC-107 WP_068981614.1 product_name: class C beta-lactamase ADC-107 -> extended-spectrum class C beta-lactamase ADC-107 blaADC-109 WP_136512052.1 product_name: class C beta-lactamase ADC-109 -> extended-spectrum class C beta-lactamase ADC-109 blaADC-11 WP_001211205.1 product_name: class C extended-spectrum beta-lactamase ADC-11 -> extended-spectrum class C beta-lactamase ADC-11 blaADC-110 WP_136512053.1 product_name: class C beta-lactamase ADC-110 -> extended-spectrum class C beta-lactamase ADC-110 blaADC-112 WP_136512054.1 product_name: class C beta-lactamase ADC-112 -> extended-spectrum class C beta-lactamase ADC-112 blaADC-113 WP_136512055.1 product_name: class C beta-lactamase ADC-113 -> extended-spectrum class C beta-lactamase ADC-113 blaADC-114 WP_125052776.1 product_name: class C beta-lactamase ADC-114 -> extended-spectrum class C beta-lactamase ADC-114 blaADC-115 WP_001211215.1 product_name: class C beta-lactamase ADC-115 -> extended-spectrum class C beta-lactamase ADC-115 blaADC-116 WP_017816757.1 product_name: class C beta-lactamase ADC-116 -> extended-spectrum class C beta-lactamase ADC-116 blaADC-117 WP_002157727.1 product_name: class C beta-lactamase ADC-117 -> extended-spectrum class C beta-lactamase ADC-117 blaADC-119 WP_004712857.1 product_name: class C beta-lactamase ADC-119 -> extended-spectrum class C beta-lactamase ADC-119 blaADC-12 WP_063857787.1 product_name: class C extended-spectrum beta-lactamase ADC-12 -> extended-spectrum class C beta-lactamase ADC-12 blaADC-120 WP_002126587.1 product_name: class C beta-lactamase ADC-120 -> extended-spectrum class C beta-lactamase ADC-120 blaADC-121 WP_005109685.1 product_name: class C beta-lactamase ADC-121 -> extended-spectrum class C beta-lactamase ADC-121 blaADC-122 WP_005123276.1 product_name: class C beta-lactamase ADC-122 -> extended-spectrum class C beta-lactamase ADC-122 blaADC-123 WP_004840559.1 product_name: class C beta-lactamase ADC-123 -> extended-spectrum class C beta-lactamase ADC-123 blaADC-125 WP_005131186.1 product_name: class C beta-lactamase ADC-125 -> extended-spectrum class C beta-lactamase ADC-125 blaADC-127 WP_005046018.1 product_name: class C beta-lactamase ADC-127 -> extended-spectrum class C beta-lactamase ADC-127 blaADC-128 WP_004643536.1 product_name: class C beta-lactamase ADC-128 -> extended-spectrum class C beta-lactamase ADC-128 blaADC-129 WP_005039111.1 product_name: class C beta-lactamase ADC-129 -> extended-spectrum class C beta-lactamase ADC-129 blaADC-13 WP_063857788.1 product_name: class C extended-spectrum beta-lactamase ADC-13 -> extended-spectrum class C beta-lactamase ADC-13 blaADC-130 WP_004886093.1 product_name: class C beta-lactamase ADC-130 -> extended-spectrum class C beta-lactamase ADC-130 blaADC-131 WP_004707701.1 product_name: class C beta-lactamase ADC-131 -> extended-spectrum class C beta-lactamase ADC-131 blaADC-132 WP_005068074.1 product_name: class C beta-lactamase ADC-132 -> extended-spectrum class C beta-lactamase ADC-132 blaADC-133 WP_004700205.1 product_name: class C beta-lactamase ADC-133 -> extended-spectrum class C beta-lactamase ADC-133 blaADC-134 WP_005307218.1 product_name: class C beta-lactamase ADC-134 -> extended-spectrum class C beta-lactamase ADC-134 blaADC-135 WP_004790939.1 product_name: class C beta-lactamase ADC-135 -> extended-spectrum class C beta-lactamase ADC-135 blaADC-136 WP_016137488.1 product_name: class C beta-lactamase ADC-136 -> extended-spectrum class C beta-lactamase ADC-136 blaADC-137 WP_016140427.1 product_name: class C beta-lactamase ADC-137 -> extended-spectrum class C beta-lactamase ADC-137 blaADC-138 WP_016146025.1 product_name: class C beta-lactamase ADC-138 -> extended-spectrum class C beta-lactamase ADC-138 blaADC-139 WP_032039838.1 product_name: class C beta-lactamase ADC-139 -> extended-spectrum class C beta-lactamase ADC-139 blaADC-14 WP_063857789.1 product_name: class C extended-spectrum beta-lactamase ADC-14 -> extended-spectrum class C beta-lactamase ADC-14 blaADC-140 WP_001211209.1 product_name: class C beta-lactamase ADC-140 -> extended-spectrum class C beta-lactamase ADC-140 blaADC-141 WP_032062810.1 product_name: class C beta-lactamase ADC-141 -> extended-spectrum class C beta-lactamase ADC-141 blaADC-143 WP_033502167.1 product_name: class C beta-lactamase ADC-143 -> extended-spectrum class C beta-lactamase ADC-143 blaADC-144 WP_001211214.1 product_name: class C beta-lactamase ADC-144 -> cefepime-hydrolyzing class C beta-lactamase ADC-144 pubmed_reference: -> 21788456 blaADC-145 WP_039270258.1 product_name: class C beta-lactamase ADC-145 -> extended-spectrum class C beta-lactamase ADC-145 blaADC-146 WP_039258389.1 product_name: class C beta-lactamase ADC-146 -> extended-spectrum class C beta-lactamase ADC-146 blaADC-147 WP_044718369.1 product_name: class C beta-lactamase ADC-147 -> extended-spectrum class C beta-lactamase ADC-147 blaADC-148 WP_039246976.1 product_name: class C beta-lactamase ADC-148 -> extended-spectrum class C beta-lactamase ADC-148 blaADC-149 WP_014207272.1 product_name: class C beta-lactamase ADC-149 -> extended-spectrum class C beta-lactamase ADC-149 blaADC-15 WP_063857790.1 product_name: class C extended-spectrum beta-lactamase ADC-15 -> extended-spectrum class C beta-lactamase ADC-15 blaADC-150 WP_017386568.1 product_name: class C beta-lactamase ADC-150 -> extended-spectrum class C beta-lactamase ADC-150 blaADC-151 WP_063099318.1 product_name: class C beta-lactamase ADC-151 -> extended-spectrum class C beta-lactamase ADC-151 blaADC-152 WP_001211233.1 product_name: class C beta-lactamase ADC-152 -> extended-spectrum class C beta-lactamase ADC-152 blaADC-153 WP_099156045.1 product_name: class C beta-lactamase ADC-153 -> extended-spectrum class C beta-lactamase ADC-153 blaADC-154 WP_005138362.1 product_name: class C beta-lactamase ADC-154 -> extended-spectrum class C beta-lactamase ADC-154 blaADC-155 WP_005128228.1 product_name: class C beta-lactamase ADC-155 -> extended-spectrum class C beta-lactamase ADC-155 blaADC-156 WP_024436624.1 product_name: class C beta-lactamase ADC-156 -> extended-spectrum class C beta-lactamase ADC-156 blaADC-157 WP_088245227.1 product_name: class C beta-lactamase ADC-157 -> extended-spectrum class C beta-lactamase ADC-157 blaADC-158 WP_001211227.1 product_name: class C beta-lactamase ADC-158 -> extended-spectrum class C beta-lactamase ADC-158 blaADC-159 WP_033851992.1 product_name: class C beta-lactamase ADC-159 -> extended-spectrum class C beta-lactamase ADC-159 blaADC-16 WP_063857791.1 product_name: class C extended-spectrum beta-lactamase ADC-16 -> extended-spectrum class C beta-lactamase ADC-16 blaADC-160 WP_032037870.1 product_name: class C beta-lactamase ADC-160 -> extended-spectrum class C beta-lactamase ADC-160 blaADC-162 WP_031980335.1 product_name: class C beta-lactamase ADC-162 -> extended-spectrum class C beta-lactamase ADC-162 blaADC-163 WP_057093064.1 product_name: class C beta-lactamase ADC-163 -> extended-spectrum class C beta-lactamase ADC-163 blaADC-164 WP_032068214.1 product_name: class C beta-lactamase ADC-164 -> extended-spectrum class C beta-lactamase ADC-164 blaADC-165 WP_001211239.1 product_name: class C beta-lactamase ADC-165 -> extended-spectrum class C beta-lactamase ADC-165 blaADC-166 WP_101244937.1 product_name: class C beta-lactamase ADC-166 -> extended-spectrum class C beta-lactamase ADC-166 blaADC-167 WP_002046804.1 product_name: class C beta-lactamase ADC-167 -> extended-spectrum class C beta-lactamase ADC-167 blaADC-168 WP_101244938.1 product_name: class C beta-lactamase ADC-168 -> extended-spectrum class C beta-lactamase ADC-168 blaADC-169 WP_001211212.1 product_name: class C beta-lactamase ADC-169 -> extended-spectrum class C beta-lactamase ADC-169 blaADC-17 WP_063857792.1 product_name: class C extended-spectrum beta-lactamase ADC-17 -> extended-spectrum class C beta-lactamase ADC-17 blaADC-170 WP_102607458.1 product_name: class C beta-lactamase ADC-170 -> extended-spectrum class C beta-lactamase ADC-170 blaADC-171 WP_031961878.1 product_name: class C beta-lactamase ADC-171 -> cefepime-hydrolyzing class C beta-lactamase ADC-171 blaADC-172 WP_032027415.1 product_name: class C beta-lactamase ADC-172 -> cefepime-hydrolyzing class C beta-lactamase ADC-172 blaADC-173 WP_032071188.1 product_name: class C beta-lactamase ADC-173 -> cefepime-hydrolyzing class C beta-lactamase ADC-173 blaADC-174 WP_114699268.1 product_name: class C beta-lactamase ADC-174 -> extended-spectrum class C beta-lactamase ADC-174 blaADC-175 WP_001211208.1 product_name: class C beta-lactamase ADC-175 -> extended-spectrum class C beta-lactamase ADC-175 blaADC-176 WP_001159761.1 product_name: class C beta-lactamase ADC-176 -> extended-spectrum class C beta-lactamase ADC-176 blaADC-177 WP_114699269.1 product_name: class C beta-lactamase ADC-177 -> cefepime-hydrolyzing class C beta-lactamase ADC-177 pubmed_reference: -> 21788456 blaADC-178 WP_114699270.1 product_name: class C beta-lactamase ADC-178 -> extended-spectrum class C beta-lactamase ADC-178 blaADC-179 WP_114699271.1 product_name: class C beta-lactamase ADC-179 -> extended-spectrum class C beta-lactamase ADC-179 blaADC-18 WP_002118772.1 product_name: class C extended-spectrum beta-lactamase ADC-18 -> extended-spectrum class C beta-lactamase ADC-18 blaADC-180 WP_114699272.1 product_name: class C beta-lactamase ADC-180 -> extended-spectrum class C beta-lactamase ADC-180 blaADC-181 WP_046693238.1 product_name: class C beta-lactamase ADC-181 -> extended-spectrum class C beta-lactamase ADC-181 blaADC-182 WP_057691114.1 product_name: class C beta-lactamase ADC-182 -> extended-spectrum class C beta-lactamase ADC-182 blaADC-183 WP_128268232.1 product_name: class C beta-lactamase ADC-183 -> extended-spectrum class C beta-lactamase ADC-183 blaADC-184 WP_059247009.1 product_name: class C beta-lactamase ADC-184 -> extended-spectrum class C beta-lactamase ADC-184 blaADC-185 WP_001211210.1 product_name: class C beta-lactamase ADC-185 -> extended-spectrum class C beta-lactamase ADC-185 blaADC-186 WP_072292271.1 product_name: class C beta-lactamase ADC-186 -> extended-spectrum class C beta-lactamase ADC-186 blaADC-187 WP_136512056.1 product_name: class C beta-lactamase ADC-187 -> extended-spectrum class C beta-lactamase ADC-187 blaADC-188 WP_136512057.1 product_name: class C beta-lactamase ADC-188 -> extended-spectrum class C beta-lactamase ADC-188 blaADC-189 WP_136512058.1 product_name: class C beta-lactamase ADC-189 -> extended-spectrum class C beta-lactamase ADC-189 blaADC-19 WP_063857793.1 product_name: class C extended-spectrum beta-lactamase ADC-19 -> extended-spectrum class C beta-lactamase ADC-19 blaADC-190 WP_136512059.1 product_name: class C beta-lactamase ADC-190 -> extended-spectrum class C beta-lactamase ADC-190 blaADC-191 WP_003112187.1 product_name: class C beta-lactamase ADC-191 -> extended-spectrum class C beta-lactamase ADC-191 blaADC-192 WP_136512060.1 product_name: class C beta-lactamase ADC-192 -> extended-spectrum class C beta-lactamase ADC-192 blaADC-193 WP_013197184.1 product_name: class C beta-lactamase ADC-193 -> extended-spectrum class C beta-lactamase ADC-193 blaADC-194 WP_133972424.1 product_name: class C beta-lactamase ADC-194 -> extended-spectrum class C beta-lactamase ADC-194 blaADC-195 WP_140423305.1 product_name: class C beta-lactamase ADC-195 -> extended-spectrum class C beta-lactamase ADC-195 blaADC-196 WP_145850033.1 product_name: class C beta-lactamase ADC-196 -> extended-spectrum class C beta-lactamase ADC-196 blaADC-197 WP_150823452.1 product_name: class C beta-lactamase ADC-197 -> extended-spectrum class C beta-lactamase ADC-197 blaADC-198 WP_150823453.1 product_name: class C beta-lactamase ADC-198 -> extended-spectrum class C beta-lactamase ADC-198 blaADC-199 WP_114166683.1 product_name: class C beta-lactamase ADC-199 -> extended-spectrum class C beta-lactamase ADC-199 blaADC-2 WP_004746565.1 product_name: class C beta-lactamase ADC-2 -> extended-spectrum class C beta-lactamase ADC-2 blaADC-20 WP_063857794.1 product_name: class C extended-spectrum beta-lactamase ADC-20 -> extended-spectrum class C beta-lactamase ADC-20 blaADC-200 WP_150823454.1 product_name: class C beta-lactamase ADC-200 -> extended-spectrum class C beta-lactamase ADC-200 blaADC-201 WP_150823455.1 product_name: class C beta-lactamase ADC-201 -> extended-spectrum class C beta-lactamase ADC-201 blaADC-202 WP_150823456.1 product_name: class C beta-lactamase ADC-202 -> extended-spectrum class C beta-lactamase ADC-202 blaADC-203 WP_032000414.1 product_name: class C beta-lactamase ADC-203 -> extended-spectrum class C beta-lactamase ADC-203 blaADC-204 WP_150823457.1 product_name: class C beta-lactamase ADC-204 -> extended-spectrum class C beta-lactamase ADC-204 blaADC-205 WP_150823458.1 product_name: class C beta-lactamase ADC-205 -> extended-spectrum class C beta-lactamase ADC-205 blaADC-206 WP_150823459.1 product_name: class C beta-lactamase ADC-206 -> extended-spectrum class C beta-lactamase ADC-206 blaADC-207 WP_130173437.1 product_name: class C beta-lactamase ADC-207 -> extended-spectrum class C beta-lactamase ADC-207 blaADC-208 WP_150823460.1 product_name: class C beta-lactamase ADC-208 -> extended-spectrum class C beta-lactamase ADC-208 blaADC-209 WP_150823461.1 product_name: class C beta-lactamase ADC-209 -> extended-spectrum class C beta-lactamase ADC-209 blaADC-21 WP_063857795.1 product_name: class C extended-spectrum beta-lactamase ADC-21 -> extended-spectrum class C beta-lactamase ADC-21 blaADC-210 WP_150823462.1 product_name: class C beta-lactamase ADC-210 -> extended-spectrum class C beta-lactamase ADC-210 blaADC-211 WP_150823463.1 product_name: class C beta-lactamase ADC-211 -> extended-spectrum class C beta-lactamase ADC-211 blaADC-212 WP_031975357.1 product_name: class C beta-lactamase ADC-212 -> extended-spectrum class C beta-lactamase ADC-212 blaADC-213 WP_078230092.1 product_name: class C beta-lactamase ADC-213 -> extended-spectrum class C beta-lactamase ADC-213 blaADC-214 WP_060454527.1 product_name: class C beta-lactamase ADC-214 -> extended-spectrum class C beta-lactamase ADC-214 blaADC-215 WP_039098799.1 product_name: class C beta-lactamase ADC-215 -> extended-spectrum class C beta-lactamase ADC-215 blaADC-216 WP_039211240.1 product_name: class C beta-lactamase ADC-216 -> extended-spectrum class C beta-lactamase ADC-216 blaADC-217 WP_060470109.1 product_name: class C beta-lactamase ADC-217 -> extended-spectrum class C beta-lactamase ADC-217 blaADC-218 WP_078216190.1 product_name: class C beta-lactamase ADC-218 -> extended-spectrum class C beta-lactamase ADC-218 blaADC-219 WP_039213353.1 product_name: class C beta-lactamase ADC-219 -> cefepime-hydrolyzing class C beta-lactamase ADC-219 blaADC-22 WP_063857796.1 product_name: class C extended-spectrum beta-lactamase ADC-22 -> extended-spectrum class C beta-lactamase ADC-22 blaADC-220 WP_087876534.1 product_name: class C beta-lactamase ADC-220 -> extended-spectrum class C beta-lactamase ADC-220 blaADC-221 WP_156404644.1 product_name: class C beta-lactamase ADC-221 -> extended-spectrum class C beta-lactamase ADC-221 blaADC-222 WP_031960999.1 product_name: class C beta-lactamase ADC-222 -> extended-spectrum class C beta-lactamase ADC-222 blaADC-223 WP_064987478.1 product_name: class C beta-lactamase ADC-223 -> extended-spectrum class C beta-lactamase ADC-223 blaADC-224 WP_064907831.1 product_name: class C beta-lactamase ADC-224 -> cefepime-hydrolyzing class C beta-lactamase ADC-224 blaADC-225 WP_160164833.1 product_name: class C beta-lactamase ADC-225 -> cefepime-hydrolyzing class C beta-lactamase ADC-225 blaADC-226 WP_001211224.1 product_name: class C beta-lactamase ADC-226 -> extended-spectrum class C beta-lactamase ADC-226 blaADC-227 WP_160164834.1 product_name: class C beta-lactamase ADC-227 -> extended-spectrum class C beta-lactamase ADC-227 blaADC-228 WP_160164835.1 product_name: class C beta-lactamase ADC-228 -> cefepime-hydrolyzing class C beta-lactamase ADC-228 blaADC-229 WP_160164836.1 product_name: class C beta-lactamase ADC-229 -> extended-spectrum class C beta-lactamase ADC-229 blaADC-23 WP_063857797.1 product_name: class C extended-spectrum beta-lactamase ADC-23 -> extended-spectrum class C beta-lactamase ADC-23 blaADC-230 WP_160164837.1 product_name: class C beta-lactamase ADC-230 -> extended-spectrum class C beta-lactamase ADC-230 blaADC-231 WP_160164838.1 product_name: class C beta-lactamase ADC-231 -> extended-spectrum class C beta-lactamase ADC-231 blaADC-232 WP_064907116.1 product_name: class C beta-lactamase ADC-232 -> cefepime-hydrolyzing class C beta-lactamase ADC-232 blaADC-233 WP_031950434.1 product_name: class C beta-lactamase ADC-233 -> cefepime-hydrolyzing class C beta-lactamase ADC-233 blaADC-234 WP_159162532.1 product_name: class C beta-lactamase ADC-234 -> extended-spectrum class C beta-lactamase ADC-234 blaADC-235 WP_132038428.1 product_name: class C beta-lactamase ADC-235 -> extended-spectrum class C beta-lactamase ADC-235 blaADC-236 WP_176673601.1 product_name: class C beta-lactamase ADC-236 -> extended-spectrum class C beta-lactamase ADC-236 blaADC-237 WP_086262823.1 product_name: class C beta-lactamase ADC-237 -> extended-spectrum class C beta-lactamase ADC-237 blaADC-238 WP_002058891.1 product_name: class C beta-lactamase ADC-238 -> extended-spectrum class C beta-lactamase ADC-238 blaADC-239 WP_031981814.1 product_name: class C beta-lactamase ADC-239 -> extended-spectrum class C beta-lactamase ADC-239 blaADC-24 WP_136512061.1 product_name: class C beta-lactamase ADC-24 -> extended-spectrum class C beta-lactamase ADC-24 blaADC-240 WP_001211207.1 product_name: class C beta-lactamase ADC-240 -> extended-spectrum class C beta-lactamase ADC-240 blaADC-241 WP_001211198.1 product_name: class C beta-lactamase ADC-241 -> extended-spectrum class C beta-lactamase ADC-241 blaADC-242 WP_047481394.1 product_name: class C beta-lactamase ADC-242 -> extended-spectrum class C beta-lactamase ADC-242 blaADC-243 WP_001211199.1 product_name: class C beta-lactamase ADC-243 -> extended-spectrum class C beta-lactamase ADC-243 blaADC-244 WP_032017586.1 product_name: class C beta-lactamase ADC-244 -> extended-spectrum class C beta-lactamase ADC-244 blaADC-245 WP_032005249.1 product_name: class C beta-lactamase ADC-245 -> extended-spectrum class C beta-lactamase ADC-245 blaADC-246 WP_031976577.1 product_name: class C beta-lactamase ADC-246 -> extended-spectrum class C beta-lactamase ADC-246 blaADC-247 WP_032058755.1 product_name: class C beta-lactamase ADC-247 -> extended-spectrum class C beta-lactamase ADC-247 blaADC-248 WP_021511005.1 product_name: class C beta-lactamase ADC-248 -> extended-spectrum class C beta-lactamase ADC-248 blaADC-249 WP_001211200.1 product_name: class C beta-lactamase ADC-249 -> extended-spectrum class C beta-lactamase ADC-249 blaADC-25 WP_001211217.1 product_name: class C beta-lactamase ADC-25 -> extended-spectrum class C beta-lactamase ADC-25 blaADC-250 WP_086329657.1 product_name: class C beta-lactamase ADC-250 -> extended-spectrum class C beta-lactamase ADC-250 blaADC-251 WP_086443396.1 product_name: class C beta-lactamase ADC-251 -> extended-spectrum class C beta-lactamase ADC-251 blaADC-252 WP_086399847.1 product_name: class C beta-lactamase ADC-252 -> extended-spectrum class C beta-lactamase ADC-252 blaADC-253 WP_086394244.1 product_name: class C beta-lactamase ADC-253 -> extended-spectrum class C beta-lactamase ADC-253 blaADC-254 WP_031996777.1 product_name: class C beta-lactamase ADC-254 -> extended-spectrum class C beta-lactamase ADC-254 blaADC-255 WP_022575343.1 product_name: class C beta-lactamase ADC-255 -> extended-spectrum class C beta-lactamase ADC-255 blaADC-256 WP_204376223.1 product_name: class C beta-lactamase ADC-256 -> extended-spectrum class C beta-lactamase ADC-256 blaADC-257 WP_116020564.1 product_name: class C beta-lactamase ADC-257 -> extended-spectrum class C beta-lactamase ADC-257 blaADC-258 WP_114259520.1 product_name: class C beta-lactamase ADC-258 -> extended-spectrum class C beta-lactamase ADC-258 blaADC-259 WP_046882921.1 product_name: class C beta-lactamase ADC-259 -> extended-spectrum class C beta-lactamase ADC-259 blaADC-26 WP_001211238.1 product_name: class C extended-spectrum beta-lactamase ADC-26 -> extended-spectrum class C beta-lactamase ADC-26 blaADC-260 WP_231869648.1 product_name: class C beta-lactamase ADC-260 -> extended-spectrum class C beta-lactamase ADC-260 blaADC-261 WP_240067715.1 product_name: class C beta-lactamase ADC-261 -> cefepime-hydrolyzing class C beta-lactamase ADC-261 pubmed_reference: -> 21788456 blaADC-262 WP_213702342.1 product_name: class C beta-lactamase ADC-262 -> extended-spectrum class C beta-lactamase ADC-262 blaADC-263 WP_109433738.1 product_name: class C beta-lactamase ADC-263 -> extended-spectrum class C beta-lactamase ADC-263 blaADC-264 WP_240067716.1 product_name: class C beta-lactamase ADC-264 -> extended-spectrum class C beta-lactamase ADC-264 blaADC-265 WP_086265799.1 product_name: class C beta-lactamase ADC-265 -> extended-spectrum class C beta-lactamase ADC-265 blaADC-29 WP_069174569.1 product_name: class C extended-spectrum beta-lactamase ADC-29 -> extended-spectrum class C beta-lactamase ADC-29 blaADC-3 WP_063857798.1 product_name: class C beta-lactamase ADC-3 -> extended-spectrum class C beta-lactamase ADC-3 blaADC-30 WP_001211218.1 product_name: class C extended-spectrum beta-lactamase ADC-30 -> extended-spectrum class C beta-lactamase ADC-30 blaADC-31 WP_001211223.1 product_name: class C extended-spectrum beta-lactamase ADC-31 -> extended-spectrum class C beta-lactamase ADC-31 blaADC-32 WP_004739487.1 product_name: class C extended-spectrum beta-lactamase ADC-32 -> extended-spectrum class C beta-lactamase ADC-32 blaADC-33 WP_001211220.1 product_name: cefepime-hydrolyzing class C extended-spectrum beta-lactamase ADC-33 -> cefepime-hydrolyzing class C beta-lactamase ADC-33 blaADC-38 WP_063857799.1 product_name: class C beta-lactamase ADC-38 -> extended-spectrum class C beta-lactamase ADC-38 blaADC-39 WP_063857800.1 product_name: class C beta-lactamase ADC-39 -> extended-spectrum class C beta-lactamase ADC-39 blaADC-4 WP_063857801.1 product_name: class C beta-lactamase ADC-4 -> extended-spectrum class C beta-lactamase ADC-4 blaADC-41 WP_063857802.1 product_name: class C extended-spectrum beta-lactamase ADC-41 -> extended-spectrum class C beta-lactamase ADC-41 blaADC-42 WP_063857803.1 product_name: class C extended-spectrum beta-lactamase ADC-42 -> extended-spectrum class C beta-lactamase ADC-42 blaADC-43 WP_032055358.1 product_name: class C extended-spectrum beta-lactamase ADC-43 -> extended-spectrum class C beta-lactamase ADC-43 blaADC-44 WP_063857804.1 product_name: class C extended-spectrum beta-lactamase ADC-44 -> extended-spectrum class C beta-lactamase ADC-44 blaADC-5 WP_038405930.1 product_name: class C beta-lactamase ADC-5 -> extended-spectrum class C beta-lactamase ADC-5 blaADC-50 WP_031965243.1 product_name: class C extended-spectrum beta-lactamase ADC-50 -> extended-spectrum class C beta-lactamase ADC-50 blaADC-51 WP_063857805.1 product_name: class C extended-spectrum beta-lactamase ADC-51 -> extended-spectrum class C beta-lactamase ADC-51 blaADC-52 WP_001211232.1 product_name: class C extended-spectrum beta-lactamase ADC-52 -> extended-spectrum class C beta-lactamase ADC-52 blaADC-53 WP_063857806.1 product_name: class C extended-spectrum beta-lactamase ADC-53 -> extended-spectrum class C beta-lactamase ADC-53 blaADC-54 WP_063857807.1 product_name: class C beta-lactamase ADC-54 -> extended-spectrum class C beta-lactamase ADC-54 blaADC-56 WP_031973850.1 product_name: cefepime-hydrolyzing class C extended-spectrum beta-lactamase ADC-56 -> cefepime-hydrolyzing class C beta-lactamase ADC-56 blaADC-57 WP_001211226.1 product_name: class C beta-lactamase ADC-57 -> extended-spectrum class C beta-lactamase ADC-57 blaADC-58 WP_063857808.1 product_name: class C beta-lactamase ADC-58 -> extended-spectrum class C beta-lactamase ADC-58 blaADC-59 WP_063857809.1 product_name: class C beta-lactamase ADC-59 -> extended-spectrum class C beta-lactamase ADC-59 blaADC-6 WP_017725267.1 product_name: class C beta-lactamase ADC-6 -> extended-spectrum class C beta-lactamase ADC-6 blaADC-60 WP_063857810.1 product_name: class C beta-lactamase ADC-60 -> extended-spectrum class C beta-lactamase ADC-60 blaADC-61 WP_033503051.1 product_name: class C beta-lactamase ADC-61 -> extended-spectrum class C beta-lactamase ADC-61 blaADC-62 WP_063857811.1 product_name: class C beta-lactamase ADC-62 -> extended-spectrum class C beta-lactamase ADC-62 blaADC-63 WP_063857812.1 product_name: class C beta-lactamase ADC-63 -> extended-spectrum class C beta-lactamase ADC-63 blaADC-65 WP_136512062.1 product_name: class C beta-lactamase ADC-65 -> extended-spectrum class C beta-lactamase ADC-65 blaADC-66 WP_136512063.1 product_name: class C beta-lactamase ADC-66 -> extended-spectrum class C beta-lactamase ADC-66 blaADC-67 WP_063857814.1 product_name: class C beta-lactamase ADC-67 -> extended-spectrum class C beta-lactamase ADC-67 blaADC-7 WP_063857816.1 product_name: class C beta-lactamase ADC-7 -> extended-spectrum class C beta-lactamase ADC-7 blaADC-70 WP_017480710.1 product_name: class C extended-spectrum beta-lactamase ADC-70 -> extended-spectrum class C beta-lactamase ADC-70 blaADC-73 WP_001211219.1 product_name: class C extended-spectrum beta-lactamase ADC-73 -> extended-spectrum class C beta-lactamase ADC-73 blaADC-74 WP_001211203.1 product_name: class C extended-spectrum beta-lactamase ADC-74 -> extended-spectrum class C beta-lactamase ADC-74 blaADC-75 WP_063857817.1 product_name: class C extended-spectrum beta-lactamase ADC-75 -> extended-spectrum class C beta-lactamase ADC-75 blaADC-76 WP_001211237.1 product_name: class C extended-spectrum beta-lactamase ADC-76 -> extended-spectrum class C beta-lactamase ADC-76 blaADC-77 WP_063857818.1 product_name: class C extended-spectrum beta-lactamase ADC-77 -> extended-spectrum class C beta-lactamase ADC-77 blaADC-78 WP_057691006.1 product_name: class C extended-spectrum beta-lactamase ADC-78 -> extended-spectrum class C beta-lactamase ADC-78 blaADC-79 WP_001159760.1 product_name: class C extended-spectrum beta-lactamase ADC-79 -> extended-spectrum class C beta-lactamase ADC-79 blaADC-80 WP_029424536.1 product_name: class C extended-spectrum beta-lactamase ADC-80 -> extended-spectrum class C beta-lactamase ADC-80 blaADC-81 WP_059262723.1 product_name: class C extended-spectrum beta-lactamase ADC-81 -> extended-spectrum class C beta-lactamase ADC-81 blaADC-82 WP_001211216.1 product_name: class C extended-spectrum beta-lactamase ADC-82 -> extended-spectrum class C beta-lactamase ADC-82 blaADC-83 WP_068981615.1 product_name: class C beta-lactamase ADC-83 -> extended-spectrum class C beta-lactamase ADC-83 blaADC-84 WP_068981616.1 product_name: class C beta-lactamase ADC-84 -> extended-spectrum class C beta-lactamase ADC-84 blaADC-85 WP_068981617.1 product_name: class C beta-lactamase ADC-85 -> extended-spectrum class C beta-lactamase ADC-85 blaADC-86 WP_068981618.1 product_name: class C beta-lactamase ADC-86 -> extended-spectrum class C beta-lactamase ADC-86 blaADC-87 WP_068981619.1 product_name: class C beta-lactamase ADC-87 -> extended-spectrum class C beta-lactamase ADC-87 blaADC-88 WP_001211221.1 product_name: class C beta-lactamase ADC-88 -> extended-spectrum class C beta-lactamase ADC-88 blaADC-89 WP_068981620.1 product_name: class C beta-lactamase ADC-89 -> extended-spectrum class C beta-lactamase ADC-89 blaADC-90 WP_068981621.1 product_name: class C beta-lactamase ADC-90 -> extended-spectrum class C beta-lactamase ADC-90 blaADC-91 WP_068981622.1 product_name: class C beta-lactamase ADC-91 -> extended-spectrum class C beta-lactamase ADC-91 blaADC-92 WP_068981623.1 product_name: class C beta-lactamase ADC-92 -> extended-spectrum class C beta-lactamase ADC-92 blaADC-93 WP_068981624.1 product_name: class C beta-lactamase ADC-93 -> extended-spectrum class C beta-lactamase ADC-93 blaADC-94 WP_068981625.1 product_name: class C beta-lactamase ADC-94 -> extended-spectrum class C beta-lactamase ADC-94 blaADC-95 WP_068981626.1 product_name: class C beta-lactamase ADC-95 -> extended-spectrum class C beta-lactamase ADC-95 blaADC-96 WP_068981627.1 product_name: class C beta-lactamase ADC-96 -> extended-spectrum class C beta-lactamase ADC-96 blaADC-97 WP_068981628.1 product_name: class C beta-lactamase ADC-97 -> extended-spectrum class C beta-lactamase ADC-97 blaADC-98 WP_068981629.1 product_name: class C beta-lactamase ADC-98 -> extended-spectrum class C beta-lactamase ADC-98 blaADC-99 WP_068981630.1 product_name: class C beta-lactamase ADC-99 -> extended-spectrum class C beta-lactamase ADC-99 blaAST-1 WP_063857821.1 product_name: class A broad-spectrum beta-lactamase AST-1 -> broad-spectrum class A beta-lactamase AST-1 blaBEL-1 WP_063857830.1 product_name: class A extended-spectrum beta-lactamase BEL-1 -> extended-spectrum class A beta-lactamase BEL-1 blaBEL-2 WP_063857831.1 product_name: class A extended-spectrum beta-lactamase BEL-2 -> extended-spectrum class A beta-lactamase BEL-2 blaBEL-3 WP_063857832.1 product_name: class A extended-spectrum beta-lactamase BEL-3 -> extended-spectrum class A beta-lactamase BEL-3 blaBEL-4 WP_065158950.1 product_name: class A extended-spectrum beta-lactamase BEL-4 -> extended-spectrum class A beta-lactamase BEL-4 blaCARB-10 WP_063857836.1 product_name: RTG family carbenicillin-hydrolyzing class A extended-spectrum beta-lactamase CARB-10 -> RTG family carbenicillin-hydrolyzing extended-spectrum class A beta-lactamase CARB-10 blaCGA-1 WP_002977989.1 product_name: class A extended-spectrum beta-lactamase CGA-1 -> extended-spectrum class A beta-lactamase CGA-1 blaCIA-1 WP_034735227.1 product_name: class A extended-spectrum beta-lactamase CIA-1 -> extended-spectrum class A beta-lactamase CIA-1 blaCIA-2 WP_063859465.1 product_name: class A extended-spectrum beta-lactamase CIA-2 -> extended-spectrum class A beta-lactamase CIA-2 blaCIA-3 WP_063859478.1 product_name: class A extended-spectrum beta-lactamase CIA-3 -> extended-spectrum class A beta-lactamase CIA-3 blaCIA-4 WP_027373439.1 product_name: class A extended-spectrum beta-lactamase CIA-4 -> extended-spectrum class A beta-lactamase CIA-4 blaCME-1 WP_059330348.1 product_name: class A extended-spectrum beta-lactamase CME-1 -> extended-spectrum class A beta-lactamase CME-1 blaCME-2 WP_063859570.1 product_name: class A extended-spectrum beta-lactamase CME-2 -> extended-spectrum class A beta-lactamase CME-2 blaCME-3 WP_009085188.1 product_name: class A extended-spectrum beta-lactamase CME-3 -> extended-spectrum class A beta-lactamase CME-3 blaCMY-179 WP_187259226.1 gene_family: blaCFE -> blaCMY blaCMY-30 WP_000976513.1 product_name: class C extended-spectrum beta-lactamase CMY-30 -> extended-spectrum class C beta-lactamase CMY-30 blaCMY-37 WP_063859838.1 product_name: class C extended-spectrum beta-lactamase CMY-37 -> extended-spectrum class C beta-lactamase CMY-37 blaCMY-42 WP_039023136.1 product_name: class C extended-spectrum beta-lactamase CMY-42 -> extended-spectrum class C beta-lactamase CMY-42 blaCMY-8 WP_012477380.1 product_name: CMY-1/MOX family class C extended-spectrum beta-lactamase CMY-8 -> CMY-1/MOX family extended-spectrum class C beta-lactamase CMY-8 blaCMY-9 WP_032490177.1 product_name: CMY-1/MOX family class C extended-spectrum beta-lactamase CMY-9 -> CMY-1/MOX family extended-spectrum class C beta-lactamase CMY-9 blaCSP-1 WP_063859920.1 product_name: class A extended-spectrum beta-lactamase CSP-1 -> extended-spectrum class A beta-lactamase CSP-1 blaCTX-M-1 WP_013188473.1 product_name: class A extended-spectrum beta-lactamase CTX-M-1 -> extended-spectrum class A beta-lactamase CTX-M-1 blaCTX-M-10 WP_032491157.1 product_name: class A extended-spectrum beta-lactamase CTX-M-10 -> extended-spectrum class A beta-lactamase CTX-M-10 blaCTX-M-100 WP_032494234.1 product_name: class A extended-spectrum beta-lactamase CTX-M-100 -> extended-spectrum class A beta-lactamase CTX-M-100 blaCTX-M-101 WP_063859921.1 product_name: class A extended-spectrum beta-lactamase CTX-M-101 -> extended-spectrum class A beta-lactamase CTX-M-101 blaCTX-M-102 WP_063859922.1 product_name: class A extended-spectrum beta-lactamase CTX-M-102 -> extended-spectrum class A beta-lactamase CTX-M-102 blaCTX-M-103 WP_063859923.1 product_name: class A extended-spectrum beta-lactamase CTX-M-103 -> extended-spectrum class A beta-lactamase CTX-M-103 blaCTX-M-104 WP_042004849.1 product_name: class A extended-spectrum beta-lactamase CTX-M-104 -> extended-spectrum class A beta-lactamase CTX-M-104 blaCTX-M-105 WP_015059026.1 product_name: class A extended-spectrum beta-lactamase CTX-M-105 -> extended-spectrum class A beta-lactamase CTX-M-105 blaCTX-M-110 WP_063859924.1 product_name: class A extended-spectrum beta-lactamase CTX-M-110 -> extended-spectrum class A beta-lactamase CTX-M-110 blaCTX-M-111 WP_063859925.1 product_name: class A extended-spectrum beta-lactamase CTX-M-111 -> extended-spectrum class A beta-lactamase CTX-M-111 blaCTX-M-112 WP_063859926.1 product_name: class A extended-spectrum beta-lactamase CTX-M-112 -> extended-spectrum class A beta-lactamase CTX-M-112 blaCTX-M-113 WP_063859927.1 product_name: class A extended-spectrum beta-lactamase CTX-M-113 -> extended-spectrum class A beta-lactamase CTX-M-113 blaCTX-M-114 WP_063859928.1 product_name: class A extended-spectrum beta-lactamase CTX-M-114 -> extended-spectrum class A beta-lactamase CTX-M-114 blaCTX-M-115 WP_035895532.1 product_name: class A extended-spectrum beta-lactamase CTX-M-115 -> extended-spectrum class A beta-lactamase CTX-M-115 blaCTX-M-116 WP_032495225.1 product_name: class A extended-spectrum beta-lactamase CTX-M-116 -> extended-spectrum class A beta-lactamase CTX-M-116 blaCTX-M-117 WP_032495259.1 product_name: class A extended-spectrum beta-lactamase CTX-M-117 -> extended-spectrum class A beta-lactamase CTX-M-117 blaCTX-M-12 WP_032491777.1 product_name: class A extended-spectrum beta-lactamase CTX-M-12 -> extended-spectrum class A beta-lactamase CTX-M-12 blaCTX-M-121 WP_032495378.1 product_name: class A extended-spectrum beta-lactamase CTX-M-121 -> extended-spectrum class A beta-lactamase CTX-M-121 blaCTX-M-122 WP_063859932.1 product_name: class A extended-spectrum beta-lactamase CTX-M-122 -> extended-spectrum class A beta-lactamase CTX-M-122 blaCTX-M-123 WP_031942271.1 product_name: class A extended-spectrum beta-lactamase CTX-M-123 -> extended-spectrum class A beta-lactamase CTX-M-123 blaCTX-M-124 WP_063859945.1 product_name: class A extended-spectrum beta-lactamase CTX-M-124 -> extended-spectrum class A beta-lactamase CTX-M-124 blaCTX-M-125 WP_063859946.1 product_name: class A extended-spectrum beta-lactamase CTX-M-125 -> extended-spectrum class A beta-lactamase CTX-M-125 blaCTX-M-126 WP_063859947.1 product_name: class A extended-spectrum beta-lactamase CTX-M-126 -> extended-spectrum class A beta-lactamase CTX-M-126 blaCTX-M-127 WP_088245211.1 product_name: class A extended-spectrum beta-lactamase CTX-M-127 -> extended-spectrum class A beta-lactamase CTX-M-127 blaCTX-M-129 WP_063859948.1 product_name: class A extended-spectrum beta-lactamase CTX-M-129 -> extended-spectrum class A beta-lactamase CTX-M-129 blaCTX-M-13 WP_032489927.1 product_name: class A extended-spectrum beta-lactamase CTX-M-13 -> extended-spectrum class A beta-lactamase CTX-M-13 blaCTX-M-130 WP_063859949.1 product_name: class A extended-spectrum beta-lactamase CTX-M-130 -> extended-spectrum class A beta-lactamase CTX-M-130 blaCTX-M-131 WP_063859950.1 product_name: class A extended-spectrum beta-lactamase CTX-M-131 -> extended-spectrum class A beta-lactamase CTX-M-131 blaCTX-M-132 WP_063859951.1 product_name: class A extended-spectrum beta-lactamase CTX-M-132 -> extended-spectrum class A beta-lactamase CTX-M-132 blaCTX-M-134 WP_063859952.1 product_name: class A extended-spectrum beta-lactamase CTX-M-134 -> extended-spectrum class A beta-lactamase CTX-M-134 blaCTX-M-136 WP_063859953.1 product_name: class A extended-spectrum beta-lactamase CTX-M-136 -> extended-spectrum class A beta-lactamase CTX-M-136 blaCTX-M-137 WP_063859954.1 product_name: class A extended-spectrum beta-lactamase CTX-M-137 -> extended-spectrum class A beta-lactamase CTX-M-137 blaCTX-M-138 WP_070064534.1 product_name: class A extended-spectrum beta-lactamase CTX-M-138 -> extended-spectrum class A beta-lactamase CTX-M-138 blaCTX-M-139 WP_063859955.1 product_name: class A extended-spectrum beta-lactamase CTX-M-139 -> extended-spectrum class A beta-lactamase CTX-M-139 blaCTX-M-14 WP_001617865.1 product_name: class A extended-spectrum beta-lactamase CTX-M-14 -> extended-spectrum class A beta-lactamase CTX-M-14 blaCTX-M-140 WP_063108644.1 product_name: class A extended-spectrum beta-lactamase CTX-M-140 -> extended-spectrum class A beta-lactamase CTX-M-140 blaCTX-M-141 WP_063859956.1 product_name: class A extended-spectrum beta-lactamase CTX-M-141 -> extended-spectrum class A beta-lactamase CTX-M-141 blaCTX-M-142 WP_063859957.1 product_name: class A extended-spectrum beta-lactamase CTX-M-142 -> extended-spectrum class A beta-lactamase CTX-M-142 blaCTX-M-143 WP_156404649.1 product_name: class A extended-spectrum beta-lactamase CTX-M-143 -> extended-spectrum class A beta-lactamase CTX-M-143 blaCTX-M-144 WP_032495786.1 product_name: class A extended-spectrum beta-lactamase CTX-M-144 -> extended-spectrum class A beta-lactamase CTX-M-144 blaCTX-M-146 WP_102607454.1 product_name: class A extended-spectrum beta-lactamase CTX-M-146 -> extended-spectrum class A beta-lactamase CTX-M-146 blaCTX-M-147 WP_063859958.1 product_name: class A extended-spectrum beta-lactamase CTX-M-147 -> extended-spectrum class A beta-lactamase CTX-M-147 blaCTX-M-148 WP_032495787.1 product_name: class A extended-spectrum beta-lactamase CTX-M-148 -> extended-spectrum class A beta-lactamase CTX-M-148 blaCTX-M-15 WP_000239590.1 product_name: class A extended-spectrum beta-lactamase CTX-M-15 -> extended-spectrum class A beta-lactamase CTX-M-15 blaCTX-M-150 WP_063859959.1 product_name: class A extended-spectrum beta-lactamase CTX-M-150 -> extended-spectrum class A beta-lactamase CTX-M-150 blaCTX-M-151 WP_063859960.1 product_name: CTX-M-like class A extended-spectrum beta-lactamase CTX-M-151 -> CTX-M-like extended-spectrum class A beta-lactamase CTX-M-151 blaCTX-M-152 WP_063859961.1 product_name: class A extended-spectrum beta-lactamase CTX-M-152 -> extended-spectrum class A beta-lactamase CTX-M-152 blaCTX-M-153 WP_168247876.1 product_name: class A extended-spectrum beta-lactamase CTX-M-153 -> extended-spectrum class A beta-lactamase CTX-M-153 blaCTX-M-154 WP_110093562.1 product_name: class A extended-spectrum beta-lactamase CTX-M-154 -> extended-spectrum class A beta-lactamase CTX-M-154 blaCTX-M-155 WP_063859962.1 product_name: class A extended-spectrum beta-lactamase CTX-M-155 -> extended-spectrum class A beta-lactamase CTX-M-155 blaCTX-M-156 WP_063859963.1 product_name: class A extended-spectrum beta-lactamase CTX-M-156 -> extended-spectrum class A beta-lactamase CTX-M-156 blaCTX-M-157 WP_063859964.1 product_name: class A extended-spectrum beta-lactamase CTX-M-157 -> extended-spectrum class A beta-lactamase CTX-M-157 blaCTX-M-158 WP_063859965.1 product_name: class A extended-spectrum beta-lactamase CTX-M-158 -> extended-spectrum class A beta-lactamase CTX-M-158 blaCTX-M-159 WP_063859966.1 product_name: class A extended-spectrum beta-lactamase CTX-M-159 -> extended-spectrum class A beta-lactamase CTX-M-159 blaCTX-M-16 WP_063859967.1 product_name: class A extended-spectrum beta-lactamase CTX-M-16 -> extended-spectrum class A beta-lactamase CTX-M-16 blaCTX-M-160 WP_063859968.1 product_name: class A extended-spectrum beta-lactamase CTX-M-160 -> extended-spectrum class A beta-lactamase CTX-M-160 blaCTX-M-161 WP_063859969.1 product_name: class A extended-spectrum beta-lactamase CTX-M-161 -> extended-spectrum class A beta-lactamase CTX-M-161 blaCTX-M-162 WP_063859970.1 product_name: class A extended-spectrum beta-lactamase CTX-M-162 -> extended-spectrum class A beta-lactamase CTX-M-162 blaCTX-M-163 WP_063859971.1 product_name: class A extended-spectrum beta-lactamase CTX-M-163 -> extended-spectrum class A beta-lactamase CTX-M-163 blaCTX-M-164 WP_063859972.1 product_name: class A extended-spectrum beta-lactamase CTX-M-164 -> extended-spectrum class A beta-lactamase CTX-M-164 blaCTX-M-165 WP_053444694.1 product_name: class A extended-spectrum beta-lactamase CTX-M-165 -> extended-spectrum class A beta-lactamase CTX-M-165 blaCTX-M-166 WP_063859973.1 product_name: class A extended-spectrum beta-lactamase CTX-M-166 -> extended-spectrum class A beta-lactamase CTX-M-166 blaCTX-M-167 WP_063859974.1 product_name: class A extended-spectrum beta-lactamase CTX-M-167 -> extended-spectrum class A beta-lactamase CTX-M-167 blaCTX-M-168 WP_063859975.1 product_name: class A extended-spectrum beta-lactamase CTX-M-168 -> extended-spectrum class A beta-lactamase CTX-M-168 blaCTX-M-169 WP_063859976.1 product_name: class A extended-spectrum beta-lactamase CTX-M-169 -> extended-spectrum class A beta-lactamase CTX-M-169 blaCTX-M-17 WP_011117618.1 product_name: class A extended-spectrum beta-lactamase CTX-M-17 -> extended-spectrum class A beta-lactamase CTX-M-17 blaCTX-M-170 WP_063859984.1 product_name: class A extended-spectrum beta-lactamase CTX-M-170 -> extended-spectrum class A beta-lactamase CTX-M-170 blaCTX-M-171 WP_065419568.1 product_name: class A extended-spectrum beta-lactamase CTX-M-171 -> extended-spectrum class A beta-lactamase CTX-M-171 blaCTX-M-172 WP_063859993.1 product_name: class A extended-spectrum beta-lactamase CTX-M-172 -> extended-spectrum class A beta-lactamase CTX-M-172 blaCTX-M-173 WP_063859998.1 product_name: class A extended-spectrum beta-lactamase CTX-M-173 -> extended-spectrum class A beta-lactamase CTX-M-173 blaCTX-M-174 WP_063860005.1 product_name: class A extended-spectrum beta-lactamase CTX-M-174 -> extended-spectrum class A beta-lactamase CTX-M-174 blaCTX-M-175 WP_063860009.1 product_name: class A extended-spectrum beta-lactamase CTX-M-175 -> extended-spectrum class A beta-lactamase CTX-M-175 blaCTX-M-176 WP_063860014.1 product_name: class A extended-spectrum beta-lactamase CTX-M-176 -> extended-spectrum class A beta-lactamase CTX-M-176 blaCTX-M-177 WP_063860019.1 product_name: class A extended-spectrum beta-lactamase CTX-M-177 -> extended-spectrum class A beta-lactamase CTX-M-177 blaCTX-M-178 WP_104009847.1 product_name: class A extended-spectrum beta-lactamase CTX-M-178 -> extended-spectrum class A beta-lactamase CTX-M-178 blaCTX-M-179 WP_063860025.1 product_name: class A extended-spectrum beta-lactamase CTX-M-179 -> extended-spectrum class A beta-lactamase CTX-M-179 blaCTX-M-180 WP_063860034.1 product_name: class A extended-spectrum beta-lactamase CTX-M-180 -> extended-spectrum class A beta-lactamase CTX-M-180 blaCTX-M-181 WP_063860035.1 product_name: class A extended-spectrum beta-lactamase CTX-M-181 -> extended-spectrum class A beta-lactamase CTX-M-181 blaCTX-M-182 WP_063860036.1 product_name: class A extended-spectrum beta-lactamase CTX-M-182 -> extended-spectrum class A beta-lactamase CTX-M-182 blaCTX-M-183 WP_064511490.1 product_name: class A extended-spectrum beta-lactamase CTX-M-183 -> extended-spectrum class A beta-lactamase CTX-M-183 blaCTX-M-184 WP_064511491.1 product_name: class A extended-spectrum beta-lactamase CTX-M-184 -> extended-spectrum class A beta-lactamase CTX-M-184 blaCTX-M-185 WP_065102278.1 product_name: class A extended-spectrum beta-lactamase CTX-M-185 -> extended-spectrum class A beta-lactamase CTX-M-185 blaCTX-M-186 WP_065419569.1 product_name: class A extended-spectrum beta-lactamase CTX-M-186 -> extended-spectrum class A beta-lactamase CTX-M-186 blaCTX-M-187 WP_104009848.1 product_name: class A extended-spectrum beta-lactamase CTX-M-187 -> extended-spectrum class A beta-lactamase CTX-M-187 blaCTX-M-188 WP_068981632.1 product_name: class A extended-spectrum beta-lactamase CTX-M-188 -> extended-spectrum class A beta-lactamase CTX-M-188 blaCTX-M-189 WP_068981633.1 product_name: class A extended-spectrum beta-lactamase CTX-M-189 -> extended-spectrum class A beta-lactamase CTX-M-189 blaCTX-M-19 WP_063860037.1 product_name: class A extended-spectrum beta-lactamase CTX-M-19 -> extended-spectrum class A beta-lactamase CTX-M-19 blaCTX-M-190 WP_069280706.1 product_name: class A extended-spectrum beta-lactamase CTX-M-190 -> extended-spectrum class A beta-lactamase CTX-M-190 blaCTX-M-191 WP_102607451.1 product_name: class A extended-spectrum beta-lactamase CTX-M-191 -> extended-spectrum class A beta-lactamase CTX-M-191 blaCTX-M-192 WP_102607452.1 product_name: class A extended-spectrum beta-lactamase CTX-M-192 -> extended-spectrum class A beta-lactamase CTX-M-192 blaCTX-M-193 WP_077767290.1 product_name: class A extended-spectrum beta-lactamase CTX-M-193 -> extended-spectrum class A beta-lactamase CTX-M-193 blaCTX-M-194 WP_077767291.1 product_name: class A extended-spectrum beta-lactamase CTX-M-194 -> extended-spectrum class A beta-lactamase CTX-M-194 blaCTX-M-195 WP_077767292.1 product_name: class A extended-spectrum beta-lactamase CTX-M-195 -> extended-spectrum class A beta-lactamase CTX-M-195 blaCTX-M-196 WP_077767293.1 product_name: class A extended-spectrum beta-lactamase CTX-M-196 -> extended-spectrum class A beta-lactamase CTX-M-196 blaCTX-M-197 WP_085562400.1 product_name: class A extended-spectrum beta-lactamase CTX-M-197 -> extended-spectrum class A beta-lactamase CTX-M-197 blaCTX-M-198 WP_085562401.1 product_name: class A extended-spectrum beta-lactamase CTX-M-198 -> extended-spectrum class A beta-lactamase CTX-M-198 blaCTX-M-199 WP_087587947.1 product_name: class A extended-spectrum beta-lactamase CTX-M-199 -> extended-spectrum class A beta-lactamase CTX-M-199 blaCTX-M-2 WP_025368620.1 product_name: class A extended-spectrum beta-lactamase CTX-M-2 -> extended-spectrum class A beta-lactamase CTX-M-2 blaCTX-M-20 WP_063860038.1 product_name: class A extended-spectrum beta-lactamase CTX-M-20 -> extended-spectrum class A beta-lactamase CTX-M-20 blaCTX-M-200 WP_094009813.1 product_name: class A extended-spectrum beta-lactamase CTX-M-200 -> extended-spectrum class A beta-lactamase CTX-M-200 blaCTX-M-201 WP_094009814.1 product_name: class A extended-spectrum beta-lactamase CTX-M-201 -> extended-spectrum class A beta-lactamase CTX-M-201 blaCTX-M-202 WP_088245215.1 product_name: class A extended-spectrum beta-lactamase CTX-M-202 -> extended-spectrum class A beta-lactamase CTX-M-202 blaCTX-M-203 WP_088245212.1 product_name: class A extended-spectrum beta-lactamase CTX-M-203 -> extended-spectrum class A beta-lactamase CTX-M-203 blaCTX-M-204 WP_088245225.1 product_name: class A extended-spectrum beta-lactamase CTX-M-204 -> extended-spectrum class A beta-lactamase CTX-M-204 blaCTX-M-205 WP_099156053.1 product_name: class A extended-spectrum beta-lactamase CTX-M-205 -> extended-spectrum class A beta-lactamase CTX-M-205 blaCTX-M-206 WP_102607455.1 product_name: class A extended-spectrum beta-lactamase CTX-M-206 -> extended-spectrum class A beta-lactamase CTX-M-206 blaCTX-M-207 WP_102607456.1 product_name: class A extended-spectrum beta-lactamase CTX-M-207 -> extended-spectrum class A beta-lactamase CTX-M-207 blaCTX-M-208 WP_109545060.1 product_name: class A extended-spectrum beta-lactamase CTX-M-208 -> extended-spectrum class A beta-lactamase CTX-M-208 blaCTX-M-209 WP_109545061.1 product_name: class A extended-spectrum beta-lactamase CTX-M-209 -> extended-spectrum class A beta-lactamase CTX-M-209 blaCTX-M-21 WP_063860039.1 product_name: class A extended-spectrum beta-lactamase CTX-M-21 -> extended-spectrum class A beta-lactamase CTX-M-21 blaCTX-M-210 WP_109545062.1 product_name: class A extended-spectrum beta-lactamase CTX-M-210 -> extended-spectrum class A beta-lactamase CTX-M-210 blaCTX-M-211 WP_109545063.1 product_name: class A extended-spectrum beta-lactamase CTX-M-211 -> extended-spectrum class A beta-lactamase CTX-M-211 blaCTX-M-212 WP_109545064.1 product_name: class A extended-spectrum beta-lactamase CTX-M-212 -> extended-spectrum class A beta-lactamase CTX-M-212 blaCTX-M-213 WP_106924209.1 product_name: class A extended-spectrum beta-lactamase CTX-M-213 -> extended-spectrum class A beta-lactamase CTX-M-213 blaCTX-M-214 WP_109545069.1 product_name: class A extended-spectrum beta-lactamase CTX-M-214 -> extended-spectrum class A beta-lactamase CTX-M-214 blaCTX-M-215 WP_128268235.1 product_name: class A extended-spectrum beta-lactamase CTX-M-215 -> extended-spectrum class A beta-lactamase CTX-M-215 blaCTX-M-216 WP_109791209.1 product_name: class A extended-spectrum beta-lactamase CTX-M-216 -> extended-spectrum class A beta-lactamase CTX-M-216 blaCTX-M-217 WP_109791211.1 product_name: class A extended-spectrum beta-lactamase CTX-M-217 -> extended-spectrum class A beta-lactamase CTX-M-217 blaCTX-M-218 WP_109791214.1 product_name: class A extended-spectrum beta-lactamase CTX-M-218 -> extended-spectrum class A beta-lactamase CTX-M-218 blaCTX-M-219 WP_110092882.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase CTX-M-219 -> inhibitor-resistant extended-spectrum class A beta-lactamase CTX-M-219 blaCTX-M-22 WP_032491377.1 product_name: class A extended-spectrum beta-lactamase CTX-M-22 -> extended-spectrum class A beta-lactamase CTX-M-22 blaCTX-M-220 WP_111672902.1 product_name: class A extended-spectrum beta-lactamase CTX-M-220 -> extended-spectrum class A beta-lactamase CTX-M-220 blaCTX-M-221 WP_114699284.1 product_name: class A extended-spectrum beta-lactamase CTX-M-221 -> extended-spectrum class A beta-lactamase CTX-M-221 blaCTX-M-222 WP_116786829.1 product_name: class A extended-spectrum beta-lactamase CTX-M-222 -> extended-spectrum class A beta-lactamase CTX-M-222 blaCTX-M-223 WP_122630862.1 product_name: class A extended-spectrum beta-lactamase CTX-M-223 -> extended-spectrum class A beta-lactamase CTX-M-223 blaCTX-M-224 WP_094166899.1 product_name: class A extended-spectrum beta-lactamase CTX-M-224 -> extended-spectrum class A beta-lactamase CTX-M-224 blaCTX-M-225 WP_136512064.1 product_name: class A extended-spectrum beta-lactamase CTX-M-225 -> extended-spectrum class A beta-lactamase CTX-M-225 blaCTX-M-226 WP_136512065.1 product_name: class A extended-spectrum beta-lactamase CTX-M-226 -> extended-spectrum class A beta-lactamase CTX-M-226 blaCTX-M-227 WP_148044409.1 product_name: class A extended-spectrum beta-lactamase CTX-M-227 -> extended-spectrum class A beta-lactamase CTX-M-227 blaCTX-M-228 WP_148044410.1 product_name: class A extended-spectrum beta-lactamase CTX-M-228 -> extended-spectrum class A beta-lactamase CTX-M-228 blaCTX-M-229 WP_148044411.1 product_name: class A extended-spectrum beta-lactamase CTX-M-229 -> extended-spectrum class A beta-lactamase CTX-M-229 blaCTX-M-23 WP_063860040.1 product_name: class A extended-spectrum beta-lactamase CTX-M-23 -> extended-spectrum class A beta-lactamase CTX-M-23 blaCTX-M-230 WP_156404650.1 product_name: class A extended-spectrum beta-lactamase CTX-M-230 -> extended-spectrum class A beta-lactamase CTX-M-230 blaCTX-M-231 WP_156404651.1 product_name: class A extended-spectrum beta-lactamase CTX-M-231 -> extended-spectrum class A beta-lactamase CTX-M-231 blaCTX-M-232 WP_156404652.1 product_name: class A extended-spectrum beta-lactamase CTX-M-232 -> extended-spectrum class A beta-lactamase CTX-M-232 blaCTX-M-233 WP_156404653.1 product_name: class A extended-spectrum beta-lactamase CTX-M-233 -> extended-spectrum class A beta-lactamase CTX-M-233 blaCTX-M-234 WP_168247877.1 product_name: class A extended-spectrum beta-lactamase CTX-M-234 -> extended-spectrum class A beta-lactamase CTX-M-234 blaCTX-M-235 WP_168247878.1 product_name: class A extended-spectrum beta-lactamase CTX-M-235 -> extended-spectrum class A beta-lactamase CTX-M-235 blaCTX-M-236 WP_156658722.1 product_name: class A extended-spectrum beta-lactamase CTX-M-236 -> extended-spectrum class A beta-lactamase CTX-M-236 blaCTX-M-237 WP_188331864.1 product_name: class A extended-spectrum beta-lactamase CTX-M-237 -> extended-spectrum class A beta-lactamase CTX-M-237 blaCTX-M-238 WP_188331865.1 product_name: class A extended-spectrum beta-lactamase CTX-M-238 -> extended-spectrum class A beta-lactamase CTX-M-238 blaCTX-M-239 WP_188331866.1 product_name: class A extended-spectrum beta-lactamase CTX-M-239 -> extended-spectrum class A beta-lactamase CTX-M-239 blaCTX-M-24 WP_012579082.1 product_name: class A extended-spectrum beta-lactamase CTX-M-24 -> extended-spectrum class A beta-lactamase CTX-M-24 blaCTX-M-240 WP_182496339.1 product_name: class A extended-spectrum beta-lactamase CTX-M-240 -> extended-spectrum class A beta-lactamase CTX-M-240 blaCTX-M-241 WP_188331867.1 product_name: class A extended-spectrum beta-lactamase CTX-M-241 -> extended-spectrum class A beta-lactamase CTX-M-241 blaCTX-M-242 WP_190259775.1 product_name: class A extended-spectrum beta-lactamase CTX-M-242 -> extended-spectrum class A beta-lactamase CTX-M-242 blaCTX-M-243 WP_213994580.1 product_name: class A extended-spectrum beta-lactamase CTX-M-243 -> extended-spectrum class A beta-lactamase CTX-M-243 blaCTX-M-244 WP_204376225.1 product_name: class A extended-spectrum beta-lactamase CTX-M-244 -> extended-spectrum class A beta-lactamase CTX-M-244 blaCTX-M-245 WP_213994581.1 product_name: class A extended-spectrum beta-lactamase CTX-M-245 -> extended-spectrum class A beta-lactamase CTX-M-245 blaCTX-M-246 WP_213994582.1 product_name: class A extended-spectrum beta-lactamase CTX-M-246 -> extended-spectrum class A beta-lactamase CTX-M-246 blaCTX-M-25 WP_022542384.1 product_name: class A extended-spectrum beta-lactamase CTX-M-25 -> extended-spectrum class A beta-lactamase CTX-M-25 blaCTX-M-251 WP_231869645.1 product_name: class A extended-spectrum beta-lactamase CTX-M-251 -> extended-spectrum class A beta-lactamase CTX-M-251 blaCTX-M-252 WP_240067718.1 product_name: class A extended-spectrum beta-lactamase CTX-M-252 -> extended-spectrum class A beta-lactamase CTX-M-252 blaCTX-M-26 WP_063860041.1 product_name: class A extended-spectrum beta-lactamase CTX-M-26 -> extended-spectrum class A beta-lactamase CTX-M-26 blaCTX-M-27 WP_032277257.1 product_name: class A extended-spectrum beta-lactamase CTX-M-27 -> extended-spectrum class A beta-lactamase CTX-M-27 blaCTX-M-28 WP_063860042.1 product_name: class A extended-spectrum beta-lactamase CTX-M-28 -> extended-spectrum class A beta-lactamase CTX-M-28 blaCTX-M-29 WP_063860043.1 product_name: class A extended-spectrum beta-lactamase CTX-M-29 -> extended-spectrum class A beta-lactamase CTX-M-29 blaCTX-M-3 WP_011091028.1 product_name: class A extended-spectrum beta-lactamase CTX-M-3 -> extended-spectrum class A beta-lactamase CTX-M-3 blaCTX-M-30 WP_032490752.1 product_name: class A extended-spectrum beta-lactamase CTX-M-30 -> extended-spectrum class A beta-lactamase CTX-M-30 blaCTX-M-31 WP_063860044.1 product_name: class A extended-spectrum beta-lactamase CTX-M-31 -> extended-spectrum class A beta-lactamase CTX-M-31 blaCTX-M-32 WP_000239591.1 product_name: class A extended-spectrum beta-lactamase CTX-M-32 -> extended-spectrum class A beta-lactamase CTX-M-32 blaCTX-M-33 WP_032490682.1 product_name: class A extended-spectrum beta-lactamase CTX-M-33 -> extended-spectrum class A beta-lactamase CTX-M-33 blaCTX-M-34 WP_063860045.1 product_name: class A extended-spectrum beta-lactamase CTX-M-34 -> extended-spectrum class A beta-lactamase CTX-M-34 blaCTX-M-35 WP_063860046.1 product_name: class A extended-spectrum beta-lactamase CTX-M-35 -> extended-spectrum class A beta-lactamase CTX-M-35 blaCTX-M-36 WP_063860047.1 product_name: class A extended-spectrum beta-lactamase CTX-M-36 -> extended-spectrum class A beta-lactamase CTX-M-36 blaCTX-M-37 WP_063860048.1 product_name: class A extended-spectrum beta-lactamase CTX-M-37 -> extended-spectrum class A beta-lactamase CTX-M-37 blaCTX-M-38 WP_063860049.1 product_name: class A extended-spectrum beta-lactamase CTX-M-38 -> extended-spectrum class A beta-lactamase CTX-M-38 blaCTX-M-39 WP_044702041.1 product_name: class A extended-spectrum beta-lactamase CTX-M-39 -> extended-spectrum class A beta-lactamase CTX-M-39 blaCTX-M-4 WP_032489025.1 product_name: class A extended-spectrum beta-lactamase CTX-M-4 -> extended-spectrum class A beta-lactamase CTX-M-4 blaCTX-M-40 WP_063860050.1 product_name: class A extended-spectrum beta-lactamase CTX-M-40 -> extended-spectrum class A beta-lactamase CTX-M-40 blaCTX-M-41 WP_063860051.1 product_name: class A extended-spectrum beta-lactamase CTX-M-41 -> extended-spectrum class A beta-lactamase CTX-M-41 blaCTX-M-42 WP_063860052.1 product_name: class A extended-spectrum beta-lactamase CTX-M-42 -> extended-spectrum class A beta-lactamase CTX-M-42 blaCTX-M-43 WP_063860053.1 product_name: class A extended-spectrum beta-lactamase CTX-M-43 -> extended-spectrum class A beta-lactamase CTX-M-43 blaCTX-M-44 WP_063860054.1 product_name: class A extended-spectrum beta-lactamase CTX-M-44 -> extended-spectrum class A beta-lactamase CTX-M-44 blaCTX-M-46 WP_063860055.1 product_name: class A extended-spectrum beta-lactamase CTX-M-46 -> extended-spectrum class A beta-lactamase CTX-M-46 blaCTX-M-47 WP_063860056.1 product_name: class A extended-spectrum beta-lactamase CTX-M-47 -> extended-spectrum class A beta-lactamase CTX-M-47 blaCTX-M-48 WP_063860057.1 product_name: class A extended-spectrum beta-lactamase CTX-M-48 -> extended-spectrum class A beta-lactamase CTX-M-48 blaCTX-M-49 WP_063860058.1 product_name: class A extended-spectrum beta-lactamase CTX-M-49 -> extended-spectrum class A beta-lactamase CTX-M-49 blaCTX-M-5 WP_032072602.1 product_name: class A extended-spectrum beta-lactamase CTX-M-5 -> extended-spectrum class A beta-lactamase CTX-M-5 blaCTX-M-50 WP_063860059.1 product_name: class A extended-spectrum beta-lactamase CTX-M-50 -> extended-spectrum class A beta-lactamase CTX-M-50 blaCTX-M-51 WP_063860060.1 product_name: class A extended-spectrum beta-lactamase CTX-M-51 -> extended-spectrum class A beta-lactamase CTX-M-51 blaCTX-M-52 WP_063860061.1 product_name: class A extended-spectrum beta-lactamase CTX-M-52 -> extended-spectrum class A beta-lactamase CTX-M-52 blaCTX-M-53 WP_012579062.1 product_name: class A extended-spectrum beta-lactamase CTX-M-53 -> extended-spectrum class A beta-lactamase CTX-M-53 blaCTX-M-54 WP_063860062.1 product_name: class A extended-spectrum beta-lactamase CTX-M-54 -> extended-spectrum class A beta-lactamase CTX-M-54 blaCTX-M-55 WP_015387340.1 product_name: class A extended-spectrum beta-lactamase CTX-M-55 -> extended-spectrum class A beta-lactamase CTX-M-55 blaCTX-M-56 WP_063860063.1 product_name: class A extended-spectrum beta-lactamase CTX-M-56 -> extended-spectrum class A beta-lactamase CTX-M-56 blaCTX-M-58 WP_063860064.1 product_name: class A extended-spectrum beta-lactamase CTX-M-58 -> extended-spectrum class A beta-lactamase CTX-M-58 blaCTX-M-59 WP_063860065.1 product_name: class A extended-spectrum beta-lactamase CTX-M-59 -> extended-spectrum class A beta-lactamase CTX-M-59 blaCTX-M-6 WP_032489170.1 product_name: class A extended-spectrum beta-lactamase CTX-M-6 -> extended-spectrum class A beta-lactamase CTX-M-6 blaCTX-M-60 WP_063860066.1 product_name: class A extended-spectrum beta-lactamase CTX-M-60 -> extended-spectrum class A beta-lactamase CTX-M-60 blaCTX-M-61 WP_063860067.1 product_name: class A extended-spectrum beta-lactamase CTX-M-61 -> extended-spectrum class A beta-lactamase CTX-M-61 blaCTX-M-62 WP_032493168.1 product_name: class A extended-spectrum beta-lactamase CTX-M-62 -> extended-spectrum class A beta-lactamase CTX-M-62 blaCTX-M-63 WP_063860068.1 product_name: class A extended-spectrum beta-lactamase CTX-M-63 -> extended-spectrum class A beta-lactamase CTX-M-63 blaCTX-M-64 WP_032492042.1 product_name: class A extended-spectrum beta-lactamase CTX-M-64 -> extended-spectrum class A beta-lactamase CTX-M-64 blaCTX-M-65 WP_013188475.1 product_name: class A extended-spectrum beta-lactamase CTX-M-65 -> extended-spectrum class A beta-lactamase CTX-M-65 blaCTX-M-66 WP_032491954.1 product_name: class A extended-spectrum beta-lactamase CTX-M-66 -> extended-spectrum class A beta-lactamase CTX-M-66 blaCTX-M-67 WP_032492044.1 product_name: class A extended-spectrum beta-lactamase CTX-M-67 -> extended-spectrum class A beta-lactamase CTX-M-67 blaCTX-M-68 WP_063860069.1 product_name: class A extended-spectrum beta-lactamase CTX-M-68 -> extended-spectrum class A beta-lactamase CTX-M-68 blaCTX-M-69 WP_063860070.1 product_name: class A extended-spectrum beta-lactamase CTX-M-69 -> extended-spectrum class A beta-lactamase CTX-M-69 blaCTX-M-7 WP_032489171.1 product_name: class A extended-spectrum beta-lactamase CTX-M-7 -> extended-spectrum class A beta-lactamase CTX-M-7 blaCTX-M-71 WP_032492553.1 product_name: class A extended-spectrum beta-lactamase CTX-M-71 -> extended-spectrum class A beta-lactamase CTX-M-71 blaCTX-M-72 WP_032491264.1 product_name: class A extended-spectrum beta-lactamase CTX-M-72 -> extended-spectrum class A beta-lactamase CTX-M-72 blaCTX-M-73 WP_063860072.1 product_name: class A extended-spectrum beta-lactamase CTX-M-73 -> extended-spectrum class A beta-lactamase CTX-M-73 blaCTX-M-74 WP_063860073.1 product_name: class A extended-spectrum beta-lactamase CTX-M-74 -> extended-spectrum class A beta-lactamase CTX-M-74 blaCTX-M-75 WP_063860074.1 product_name: class A extended-spectrum beta-lactamase CTX-M-75 -> extended-spectrum class A beta-lactamase CTX-M-75 blaCTX-M-76 WP_063860075.1 product_name: class A extended-spectrum beta-lactamase CTX-M-76 -> extended-spectrum class A beta-lactamase CTX-M-76 blaCTX-M-77 WP_063860076.1 product_name: class A extended-spectrum beta-lactamase CTX-M-77 -> extended-spectrum class A beta-lactamase CTX-M-77 blaCTX-M-78 WP_063860077.1 product_name: class A extended-spectrum beta-lactamase CTX-M-78 -> extended-spectrum class A beta-lactamase CTX-M-78 blaCTX-M-79 WP_063860078.1 product_name: class A extended-spectrum beta-lactamase CTX-M-79 -> extended-spectrum class A beta-lactamase CTX-M-79 blaCTX-M-8 WP_032489598.1 product_name: class A extended-spectrum beta-lactamase CTX-M-8 -> extended-spectrum class A beta-lactamase CTX-M-8 blaCTX-M-80 WP_063860079.1 product_name: class A extended-spectrum beta-lactamase CTX-M-80 -> extended-spectrum class A beta-lactamase CTX-M-80 blaCTX-M-81 WP_063860080.1 product_name: class A extended-spectrum beta-lactamase CTX-M-81 -> extended-spectrum class A beta-lactamase CTX-M-81 blaCTX-M-82 WP_063860081.1 product_name: class A extended-spectrum beta-lactamase CTX-M-82 -> extended-spectrum class A beta-lactamase CTX-M-82 blaCTX-M-83 WP_063860082.1 product_name: class A extended-spectrum beta-lactamase CTX-M-83 -> extended-spectrum class A beta-lactamase CTX-M-83 blaCTX-M-84 WP_063860083.1 product_name: class A extended-spectrum beta-lactamase CTX-M-84 -> extended-spectrum class A beta-lactamase CTX-M-84 blaCTX-M-85 WP_063860084.1 product_name: class A extended-spectrum beta-lactamase CTX-M-85 -> extended-spectrum class A beta-lactamase CTX-M-85 blaCTX-M-86 WP_063860085.1 product_name: class A extended-spectrum beta-lactamase CTX-M-86 -> extended-spectrum class A beta-lactamase CTX-M-86 blaCTX-M-87 WP_032492184.1 product_name: class A extended-spectrum beta-lactamase CTX-M-87 -> extended-spectrum class A beta-lactamase CTX-M-87 blaCTX-M-88 WP_063860086.1 product_name: class A extended-spectrum beta-lactamase CTX-M-88 -> extended-spectrum class A beta-lactamase CTX-M-88 blaCTX-M-89 WP_063860087.1 product_name: class A extended-spectrum beta-lactamase CTX-M-89 -> extended-spectrum class A beta-lactamase CTX-M-89 blaCTX-M-9 WP_032489926.1 product_name: class A extended-spectrum beta-lactamase CTX-M-9 -> extended-spectrum class A beta-lactamase CTX-M-9 blaCTX-M-90 WP_063860088.1 product_name: class A extended-spectrum beta-lactamase CTX-M-90 -> extended-spectrum class A beta-lactamase CTX-M-90 blaCTX-M-91 WP_063860089.1 product_name: class A extended-spectrum beta-lactamase CTX-M-91 -> extended-spectrum class A beta-lactamase CTX-M-91 blaCTX-M-92 WP_063860090.1 product_name: class A extended-spectrum beta-lactamase CTX-M-92 -> extended-spectrum class A beta-lactamase CTX-M-92 blaCTX-M-93 WP_032495023.1 product_name: class A extended-spectrum beta-lactamase CTX-M-93 -> extended-spectrum class A beta-lactamase CTX-M-93 blaCTX-M-94 WP_063860091.1 product_name: class A extended-spectrum beta-lactamase CTX-M-94 -> extended-spectrum class A beta-lactamase CTX-M-94 blaCTX-M-95 WP_063860092.1 product_name: class A extended-spectrum beta-lactamase CTX-M-95 -> extended-spectrum class A beta-lactamase CTX-M-95 blaCTX-M-96 WP_058670847.1 product_name: class A extended-spectrum beta-lactamase CTX-M-96 -> extended-spectrum class A beta-lactamase CTX-M-96 blaCTX-M-97 WP_063860093.1 product_name: class A extended-spectrum beta-lactamase CTX-M-97 -> extended-spectrum class A beta-lactamase CTX-M-97 blaCTX-M-98 WP_032495798.1 product_name: class A extended-spectrum beta-lactamase CTX-M-98 -> extended-spectrum class A beta-lactamase CTX-M-98 blaCTX-M-99 WP_063860094.1 product_name: class A extended-spectrum beta-lactamase CTX-M-99 -> extended-spectrum class A beta-lactamase CTX-M-99 blaDES-1 WP_063860095.1 product_name: class A extended-spectrum beta-lactamase DES-1 -> extended-spectrum class A beta-lactamase DES-1 blaEC-13 WP_063860228.1 product_name: class C extended-spectrum beta-lactamase EC-13 -> extended-spectrum class C beta-lactamase EC-13 pubmed_reference: -> 16801449 blaEC-14 WP_063860233.1 product_name: class C extended-spectrum beta-lactamase EC-14 -> extended-spectrum class C beta-lactamase EC-14 pubmed_reference: -> 16801449 blaEC-15 WP_063610930.1 product_name: class C extended-spectrum beta-lactamase EC-15 -> extended-spectrum class C beta-lactamase EC-15 pubmed_reference: -> 16801449 blaEC-16 WP_063860248.1 product_name: class C extended-spectrum beta-lactamase EC-16 -> extended-spectrum class C beta-lactamase EC-16 pubmed_reference: -> 16801449 blaEC-18 WP_063860256.1 product_name: class C extended-spectrum beta-lactamase EC-18 -> extended-spectrum class C beta-lactamase EC-18 pubmed_reference: -> 16801449 blaEC-19 WP_063860263.1 product_name: class C extended-spectrum beta-lactamase EC-19 -> extended-spectrum class C beta-lactamase EC-19 pubmed_reference: -> 16801449 blaERP-1 WP_062743204.1 product_name: class A extended-spectrum beta-lactamase ERP-1 -> extended-spectrum class A beta-lactamase ERP-1 blaFAR-1 WP_070064531.1 product_name: class A extended-spectrum beta-lactamase FAR-1 -> extended-spectrum class A beta-lactamase FAR-1 blaGES-1 WP_013250881.1 product_name: class A extended-spectrum beta-lactamase GES-1 -> extended-spectrum class A beta-lactamase GES-1 blaGES-10 WP_063860499.1 product_name: class A beta-lactamase GES-10 -> extended-spectrum class A beta-lactamase GES-10 pubmed_reference: 19459951 -> 19459951,19738007 blaGES-11 WP_001211000.1 product_name: class A extended-spectrum beta-lactamase GES-11 -> extended-spectrum class A beta-lactamase GES-11 pubmed_reference: 19451292 -> 19451292,22908160 blaGES-12 WP_063860500.1 product_name: class A beta-lactamase GES-12 -> extended-spectrum class A beta-lactamase GES-12 pubmed_reference: 20805394 -> 20805394,22908160 blaGES-13 WP_063860501.1 product_name: class A beta-lactamase GES-13 -> extended-spectrum class A beta-lactamase GES-13 blaGES-14 WP_063860502.1 pubmed_reference: 20805394 -> 19738007,20805394 blaGES-15 WP_063860503.1 product_name: class A extended-spectrum beta-lactamase GES-15 -> extended-spectrum class A beta-lactamase GES-15 blaGES-16 WP_063860504.1 pubmed_reference: -> 19738007,29861147 blaGES-17 WP_063860505.1 product_name: class A beta-lactamase GES-17 -> extended-spectrum class A beta-lactamase GES-17 pubmed_reference: -> 19738007 blaGES-18 WP_063860506.1 product_name: carbapenem-hydrolyzing class A beta-lactamase GES-18 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase GES-18 pubmed_reference: 23114760 -> 19738007,23114760 blaGES-19 WP_015059045.1 product_name: class A beta-lactamase GES-19 -> extended-spectrum class A beta-lactamase GES-19 pubmed_reference: 22526300 -> 19738007,22526300 blaGES-2 WP_045912044.1 product_name: class A extended-spectrum beta-lactamase GES-2 -> extended-spectrum class A beta-lactamase GES-2 subclass: CARBAPENEM -> CEPHALOSPORIN blaGES-20 WP_015059046.1 pubmed_reference: 22526300 -> 19738007,22526300 blaGES-21 WP_063860507.1 pubmed_reference: -> 19738007 blaGES-22 WP_063860508.1 pubmed_reference: 25267671 -> 25267671,27168312 blaGES-23 WP_063860509.1 product_name: class A extended-spectrum beta-lactamase GES-23 -> extended-spectrum class A beta-lactamase GES-23 pubmed_reference: -> 19738007 blaGES-24 WP_059385191.1 pubmed_reference: -> 19738007,30289383 blaGES-25 WP_063860510.1 product_name: class A beta-lactamase GES-25 -> carbapenem-hydrolyzing class A beta-lactamase GES-25 pubmed_reference: -> 19738007 subclass: CEPHALOSPORIN -> CARBAPENEM blaGES-26 WP_063860511.1 product_name: class A beta-lactamase GES-26 -> extended-spectrum class A beta-lactamase GES-26 pubmed_reference: -> 19738007 blaGES-28 WP_063860513.1 product_name: class A beta-lactamase GES-28 -> carbapenem-hydrolyzing class A beta-lactamase GES-28 pubmed_reference: -> 19738007 subclass: CEPHALOSPORIN -> CARBAPENEM blaGES-3 WP_063860515.1 product_name: class A extended-spectrum beta-lactamase GES-3 -> extended-spectrum class A beta-lactamase GES-3 blaGES-30 WP_063860516.1 product_name: class A beta-lactamase GES-30 -> carbapenem-hydrolyzing class A beta-lactamase GES-30 pubmed_reference: -> 19738007 subclass: CEPHALOSPORIN -> CARBAPENEM blaGES-31 WP_063860517.1 product_name: class A beta-lactamase GES-31 -> extended-spectrum class A beta-lactamase GES-31 pubmed_reference: -> 19738007 blaGES-32 WP_069280709.1 product_name: class A beta-lactamase GES-32 -> extended-spectrum class A beta-lactamase GES-32 pubmed_reference: -> 19738007 blaGES-33 WP_085562419.1 product_name: class A beta-lactamase GES-33 -> carbapenem-hydrolyzing class A beta-lactamase GES-33 pubmed_reference: -> 19738007 subclass: CEPHALOSPORIN -> CARBAPENEM blaGES-38 WP_122630826.1 product_name: class A beta-lactamase GES-38 -> extended-spectrum class A beta-lactamase GES-38 pubmed_reference: -> 19738007 blaGES-39 WP_122630827.1 product_name: class A beta-lactamase GES-39 -> carbapenem-hydrolyzing class A beta-lactamase GES-39 pubmed_reference: -> 19738007 subclass: CEPHALOSPORIN -> CARBAPENEM blaGES-4 WP_063860518.1 pubmed_reference: 15273099 -> 15273099,19738007 blaGES-40 WP_123002100.1 product_name: class A beta-lactamase GES-40 -> carbapenem-hydrolyzing class A beta-lactamase GES-40 pubmed_reference: -> 19738007 subclass: CEPHALOSPORIN -> CARBAPENEM blaGES-41 WP_135350920.1 product_name: class A beta-lactamase GES-41 -> carbapenem-hydrolyzing class A beta-lactamase GES-41 pubmed_reference: -> 19738007 blaGES-44 WP_188331868.1 product_name: class A beta-lactamase GES-44 -> extended-spectrum class A beta-lactamase GES-44 pubmed_reference: -> 19738007 blaGES-45 WP_188331869.1 product_name: class A beta-lactamase GES-45 -> extended-spectrum class A beta-lactamase GES-45 pubmed_reference: -> 19738007 blaGES-47 WP_213994585.1 pubmed_reference: -> 19738007 blaGES-48 WP_213994586.1 pubmed_reference: -> 19738007 blaGES-49 WP_219860707.1 pubmed_reference: -> 19738007 blaGES-5 WP_012658785.1 pubmed_reference: 15135524 -> 15135524,19738007 blaGES-50 WP_231869588.1 pubmed_reference: -> 19738007 blaGES-51 WP_200925854.1 pubmed_reference: -> 19738007 blaGES-6 WP_032490973.1 pubmed_reference: 15135524 -> 15135524,19738007 blaGES-7 WP_032490683.1 product_name: class A extended-spectrum beta-lactamase GES-7 -> extended-spectrum class A beta-lactamase GES-7 pubmed_reference: 10952563 -> 10952563,19738007 blaGES-8 WP_063860519.1 product_name: class A extended-spectrum beta-lactamase GES-8 -> extended-spectrum class A beta-lactamase GES-8 pubmed_reference: 11679551 -> 11679551,19738007 blaGES-9 WP_063860520.1 product_name: class A beta-lactamase GES-9 -> extended-spectrum class A beta-lactamase GES-9 pubmed_reference: 16048994 -> 16048994,19738007 blaGIL-1 WP_063860521.1 product_name: class A broad-spectrum beta-lactamase GIL-1 -> broad-spectrum class A beta-lactamase GIL-1 blaGMB-1 WP_204376227.1 pubmed_reference: -> 35257174 blaKLUC-1 WP_061284984.1 product_name: class A extended-spectrum beta-lactamase KLUC-1 -> extended-spectrum class A beta-lactamase KLUC-1 blaKLUC-2 WP_032491875.1 product_name: class A extended-spectrum beta-lactamase KLUC-2 -> extended-spectrum class A beta-lactamase KLUC-2 blaKLUC-3 WP_032495491.1 product_name: class A extended-spectrum beta-lactamase KLUC-3 -> extended-spectrum class A beta-lactamase KLUC-3 blaKLUC-4 WP_032495492.1 product_name: class A extended-spectrum beta-lactamase KLUC-4 -> extended-spectrum class A beta-lactamase KLUC-4 blaKLUC-5 WP_100663667.1 product_name: class A extended-spectrum beta-lactamase KLUC-5 -> extended-spectrum class A beta-lactamase KLUC-5 blaKPC-103 WP_231869650.1 subclass: BETA-LACTAM -> CARBAPENEM blaKPC-104 WP_231869651.1 subclass: BETA-LACTAM -> CARBAPENEM blaKPC-105 WP_231869653.1 subclass: BETA-LACTAM -> CARBAPENEM blaKPC-106 WP_231869655.1 subclass: BETA-LACTAM -> CARBAPENEM blaKPC-107 WP_231869652.1 subclass: BETA-LACTAM -> CARBAPENEM blaKPC-108 WP_231869654.1 subclass: BETA-LACTAM -> CARBAPENEM blaKPC-12 WP_063860634.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-12 -> extended-spectrum class A beta-lactamase KPC-12 pubmed_reference: -> 33595757 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-123 WP_242934078.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-123 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-123 blaKPC-13 WP_063860635.1 pubmed_reference: -> 25443891 blaKPC-14 WP_063860636.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-14 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-14 blaKPC-15 WP_063860637.1 pubmed_reference: -> 25360633 blaKPC-16 WP_063860638.1 pubmed_reference: -> 25634143 blaKPC-17 WP_063860639.1 pubmed_reference: -> 25360633 blaKPC-18 WP_063860640.1 pubmed_reference: -> 26719440,27161636 blaKPC-19 WP_063860641.1 pubmed_reference: -> 28830804 blaKPC-21 WP_063860711.1 pubmed_reference: -> 30538682 blaKPC-23 WP_111672911.1 pubmed_reference: -> 30928562 blaKPC-25 WP_065419571.1 pubmed_reference: -> 34290688 blaKPC-28 WP_072081992.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-28 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-28 blaKPC-30 WP_085562399.1 pubmed_reference: -> 33809215 blaKPC-31 WP_073668892.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-31 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-31 blaKPC-32 WP_073800284.1 product_name: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-32 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-32 pubmed_reference: -> 28031201 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-33 WP_101140102.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-33 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-33 pubmed_reference: -> 28031201,33367577 blaKPC-34 WP_109545044.1 pubmed_reference: -> 29855588 blaKPC-35 WP_111273852.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-35 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-35 pubmed_reference: -> 30753572 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-36 WP_114699267.1 pubmed_reference: -> 31593765 blaKPC-39 WP_128268237.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-39 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-39 blaKPC-40 WP_115470049.1 pubmed_reference: -> 31332070,33020157,35373297 blaKPC-46 WP_148044421.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-46 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-46 blaKPC-48 WP_213994589.1 pubmed_reference: -> 31733412 blaKPC-49 WP_197749402.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-49 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-49 blaKPC-51 WP_158208923.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-51 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-51 pubmed_reference: -> 33920372 blaKPC-52 WP_158208806.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-52 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-52 pubmed_reference: -> 33920372 blaKPC-53 WP_156649232.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-53 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-53 pubmed_reference: -> 33106265 blaKPC-55 WP_168247883.1 pubmed_reference: -> 33133036 blaKPC-57 WP_171476789.1 product_name: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-57 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-57 pubmed_reference: -> 32729059 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-61 WP_179284328.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-61 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-61 pubmed_reference: -> 34228551 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-62 WP_204376229.1 product_name: class A beta-lactamase KPC-62 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-62 pubmed_reference: -> 33775814 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-63 WP_204376230.1 product_name: class A beta-lactamase KPC-63 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-63 pubmed_reference: -> 33775814 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-64 WP_204376231.1 product_name: class A beta-lactamase KPC-64 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-64 pubmed_reference: -> 33775814 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-65 WP_204376232.1 product_name: class A beta-lactamase KPC-65 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-65 pubmed_reference: -> 33775814 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-66 WP_188331871.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-66 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-66 blaKPC-68 WP_210204468.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-68 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-68 blaKPC-69 WP_210205486.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-69 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-69 blaKPC-70 WP_210205477.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-70 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-70 blaKPC-71 WP_194293134.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-71 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-71 blaKPC-72 WP_188331872.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-72 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-72 blaKPC-73 WP_188331873.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-73 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-73 blaKPC-74 WP_188331874.1 product_name: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-74 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-74 pubmed_reference: -> 34484166 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-76 WP_194293135.1 pubmed_reference: -> 34935416 blaKPC-78 WP_197749403.1 pubmed_reference: -> 34935416 blaKPC-79 WP_197749404.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-79 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-79 pubmed_reference: -> 34935416 blaKPC-82 WP_202781289.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-82 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-82 blaKPC-90 WP_219833567.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-90 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-90 pubmed_reference: -> 35019766 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-92 WP_240067725.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase KPC-92 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-92 blaKPC-94 WP_219804981.1 product_name: class A beta-lactamase KPC-94 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-94 pubmed_reference: -> 35038557 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-95 WP_219795346.1 product_name: class A beta-lactamase KPC-95 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-95 pubmed_reference: -> 35038557 subclass: CARBAPENEM -> CEPHALOSPORIN blaLRG-1 WP_063860827.1 product_name: class A extended-spectrum beta-lactamase LRG-1 -> extended-spectrum class A beta-lactamase LRG-1 blaLUT-1 WP_010798607.1 product_name: class A extended-spectrum beta-lactamase LUT-1 -> extended-spectrum class A beta-lactamase LUT-1 blaMOR-2 WP_063860842.1 pubmed_reference: -> 33920372 blaMOX-9 WP_042649345.1 genbank_nucleotide_accession: KJ746495.1 -> KJ746495.3 blaOCH-1 WP_040129485.1 product_name: class C extended-spectrum beta-lactamase OCH-1 -> extended-spectrum class C beta-lactamase OCH-1 blaOCH-2 WP_063860889.1 product_name: class C extended-spectrum beta-lactamase OCH-2 -> extended-spectrum class C beta-lactamase OCH-2 blaOCH-3 WP_063860890.1 product_name: class C extended-spectrum beta-lactamase OCH-3 -> extended-spectrum class C beta-lactamase OCH-3 blaOCH-4 WP_063860891.1 product_name: class C extended-spectrum beta-lactamase OCH-4 -> extended-spectrum class C beta-lactamase OCH-4 blaOCH-5 WP_063860892.1 product_name: class C extended-spectrum beta-lactamase OCH-5 -> extended-spectrum class C beta-lactamase OCH-5 blaOCH-6 WP_063860893.1 product_name: class C extended-spectrum beta-lactamase OCH-6 -> extended-spectrum class C beta-lactamase OCH-6 blaOCH-7 WP_029925205.1 product_name: class C extended-spectrum beta-lactamase OCH-7 -> extended-spectrum class C beta-lactamase OCH-7 blaOCH-8 WP_063860894.1 product_name: class C extended-spectrum beta-lactamase OCH-8 -> extended-spectrum class C beta-lactamase OCH-8 blaOHIO-1 WP_063860895.1 product_name: class A extended-spectrum beta-lactamase OHIO-1 -> extended-spectrum class A beta-lactamase OHIO-1 blaOKP-A-1 WP_063860896.1 product_name: class A broad-spectrum beta-lactamase OKP-A-1 -> broad-spectrum class A beta-lactamase OKP-A-1 blaOKP-A-10 WP_063860897.1 product_name: class A broad-spectrum beta-lactamase OKP-A-10 -> broad-spectrum class A beta-lactamase OKP-A-10 blaOKP-A-11 WP_063860898.1 product_name: class A broad-spectrum beta-lactamase OKP-A-11 -> broad-spectrum class A beta-lactamase OKP-A-11 blaOKP-A-12 WP_063860899.1 product_name: class A broad-spectrum beta-lactamase OKP-A-12 -> broad-spectrum class A beta-lactamase OKP-A-12 blaOKP-A-13 WP_063860900.1 product_name: class A broad-spectrum beta-lactamase OKP-A-13 -> broad-spectrum class A beta-lactamase OKP-A-13 blaOKP-A-14 WP_063860901.1 product_name: class A broad-spectrum beta-lactamase OKP-A-14 -> broad-spectrum class A beta-lactamase OKP-A-14 blaOKP-A-15 WP_063860902.1 product_name: class A broad-spectrum beta-lactamase OKP-A-15 -> broad-spectrum class A beta-lactamase OKP-A-15 blaOKP-A-16 WP_063860903.1 product_name: class A broad-spectrum beta-lactamase OKP-A-16 -> broad-spectrum class A beta-lactamase OKP-A-16 blaOKP-A-17 WP_023289605.1 product_name: class A broad-spectrum beta-lactamase OKP-A-17 -> broad-spectrum class A beta-lactamase OKP-A-17 blaOKP-A-2 WP_032452758.1 product_name: class A broad-spectrum beta-lactamase OKP-A-2 -> broad-spectrum class A beta-lactamase OKP-A-2 blaOKP-A-3 WP_044522859.1 product_name: class A broad-spectrum beta-lactamase OKP-A-3 -> broad-spectrum class A beta-lactamase OKP-A-3 blaOKP-A-4 WP_063860904.1 product_name: class A broad-spectrum beta-lactamase OKP-A-4 -> broad-spectrum class A beta-lactamase OKP-A-4 blaOKP-A-5 WP_063860905.1 product_name: class A broad-spectrum beta-lactamase OKP-A-5 -> broad-spectrum class A beta-lactamase OKP-A-5 blaOKP-A-6 WP_060590773.1 product_name: class A broad-spectrum beta-lactamase OKP-A-6 -> broad-spectrum class A beta-lactamase OKP-A-6 blaOKP-A-7 WP_063860906.1 product_name: class A broad-spectrum beta-lactamase OKP-A-7 -> broad-spectrum class A beta-lactamase OKP-A-7 blaOKP-A-8 WP_048334865.1 product_name: class A broad-spectrum beta-lactamase OKP-A-8 -> broad-spectrum class A beta-lactamase OKP-A-8 blaOKP-A-9 WP_063860907.1 product_name: class A broad-spectrum beta-lactamase OKP-A-9 -> broad-spectrum class A beta-lactamase OKP-A-9 blaOKP-B-1 WP_032456002.1 product_name: class A broad-spectrum beta-lactamase OKP-B-1 -> broad-spectrum class A beta-lactamase OKP-B-1 blaOKP-B-10 WP_063860908.1 product_name: class A broad-spectrum beta-lactamase OKP-B-10 -> broad-spectrum class A beta-lactamase OKP-B-10 blaOKP-B-11 WP_063860909.1 product_name: class A broad-spectrum beta-lactamase OKP-B-11 -> broad-spectrum class A beta-lactamase OKP-B-11 blaOKP-B-13 WP_063860910.1 product_name: class A broad-spectrum beta-lactamase OKP-B-13 -> broad-spectrum class A beta-lactamase OKP-B-13 blaOKP-B-16 WP_064183695.1 product_name: class A broad-spectrum beta-lactamase OKP-B-16 -> broad-spectrum class A beta-lactamase OKP-B-16 blaOKP-B-17 WP_063860911.1 product_name: class A broad-spectrum beta-lactamase OKP-B-17 -> broad-spectrum class A beta-lactamase OKP-B-17 blaOKP-B-18 WP_063860912.1 product_name: class A broad-spectrum beta-lactamase OKP-B-18 -> broad-spectrum class A beta-lactamase OKP-B-18 blaOKP-B-19 WP_063860913.1 product_name: class A broad-spectrum beta-lactamase OKP-B-19 -> broad-spectrum class A beta-lactamase OKP-B-19 blaOKP-B-2 WP_063860914.1 product_name: class A broad-spectrum beta-lactamase OKP-B-2 -> broad-spectrum class A beta-lactamase OKP-B-2 blaOKP-B-20 WP_063860915.1 product_name: class A broad-spectrum beta-lactamase OKP-B-20 -> broad-spectrum class A beta-lactamase OKP-B-20 blaOKP-B-21 WP_087833272.1 product_name: class A broad-spectrum beta-lactamase OKP-B-21 -> broad-spectrum class A beta-lactamase OKP-B-21 blaOKP-B-22 WP_122543028.1 product_name: class A broad-spectrum beta-lactamase OKP-B-22 -> broad-spectrum class A beta-lactamase OKP-B-22 blaOKP-B-23 WP_023318187.1 product_name: class A broad-spectrum beta-lactamase OKP-B-23 -> broad-spectrum class A beta-lactamase OKP-B-23 blaOKP-B-24 WP_156404657.1 product_name: class A broad-spectrum beta-lactamase OKP-B-24 -> broad-spectrum class A beta-lactamase OKP-B-24 blaOKP-B-3 WP_063860916.1 product_name: class A broad-spectrum beta-lactamase OKP-B-3 -> broad-spectrum class A beta-lactamase OKP-B-3 blaOKP-B-34 WP_087771722.1 product_name: class A broad-spectrum beta-lactamase OKP-B-34 -> broad-spectrum class A beta-lactamase OKP-B-34 blaOKP-B-36 WP_060655783.1 product_name: class A broad-spectrum beta-lactamase OKP-B-36 -> broad-spectrum class A beta-lactamase OKP-B-36 blaOKP-B-4 WP_063860917.1 product_name: class A broad-spectrum beta-lactamase OKP-B-4 -> broad-spectrum class A beta-lactamase OKP-B-4 blaOKP-B-40 WP_114508147.1 product_name: class A broad-spectrum beta-lactamase OKP-B-40 -> broad-spectrum class A beta-lactamase OKP-B-40 blaOKP-B-41 WP_049003700.1 product_name: class A broad-spectrum beta-lactamase OKP-B-41 -> broad-spectrum class A beta-lactamase OKP-B-41 blaOKP-B-45 WP_048324114.1 product_name: class A broad-spectrum beta-lactamase OKP-B-45 -> broad-spectrum class A beta-lactamase OKP-B-45 blaOKP-B-5 WP_063860923.1 product_name: class A broad-spectrum beta-lactamase OKP-B-5 -> broad-spectrum class A beta-lactamase OKP-B-5 blaOKP-B-6 WP_004205995.1 product_name: class A broad-spectrum beta-lactamase OKP-B-6 -> broad-spectrum class A beta-lactamase OKP-B-6 blaOKP-B-7 WP_057215100.1 product_name: class A broad-spectrum beta-lactamase OKP-B-7 -> broad-spectrum class A beta-lactamase OKP-B-7 blaOKP-B-8 WP_017900346.1 product_name: class A broad-spectrum beta-lactamase OKP-B-8 -> broad-spectrum class A beta-lactamase OKP-B-8 blaOKP-B-9 WP_063860931.1 product_name: class A broad-spectrum beta-lactamase OKP-B-9 -> broad-spectrum class A beta-lactamase OKP-B-9 blaOKP-C-1 WP_136034107.1 product_name: class A broad-spectrum beta-lactamase OKP-C-1 -> broad-spectrum class A beta-lactamase OKP-C-1 blaOKP-D-1 WP_080897395.1 product_name: class A broad-spectrum beta-lactamase OKP-D-1 -> broad-spectrum class A beta-lactamase OKP-D-1 blaORN-1 WP_004862397.1 product_name: class A broad-spectrum beta-lactamase ORN-1 -> broad-spectrum class A beta-lactamase ORN-1 blaOXA-1011 WP_211816370.1 pubmed_reference: -> 35231657 blaOXA-1040 WP_231869647.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1051 WP_240067731.1 product_name: class D beta-lactamase OXA-1051 -> OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-1051 blaOXA-1081 WP_242934101.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1095 WP_242934109.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-11 WP_063860939.1 product_name: OXA-10 family class D extended-spectrum beta-lactamase OXA-11 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-11 blaOXA-114a WP_054505840.1 product_name: oxacillin-hydrolyzing class D beta-lactamase OXA-114a -> class D beta-lactamase OXA-114a blaOXA-14 WP_064056056.1 product_name: OXA-10 family oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-14 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-14 blaOXA-141 WP_058177653.1 product_name: OXA-2 family class D extended-spectrum beta-lactamase OXA-141 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-141 blaOXA-142 WP_063861041.1 product_name: OXA-10 family oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-142 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-142 blaOXA-145 WP_063861043.1 product_name: OXA-10 family class D extended-spectrum beta-lactamase OXA-145 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-145 blaOXA-147 WP_063861045.1 product_name: OXA-10 family class D extended-spectrum beta-lactamase OXA-147 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-147 blaOXA-15 WP_063861048.1 product_name: OXA-2 family class D extended-spectrum beta-lactamase OXA-15 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-15 blaOXA-161 WP_063861101.1 product_name: OXA-2 family class D extended-spectrum beta-lactamase OXA-161 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-161 blaOXA-163 WP_063131934.1 product_name: OXA-48 family class D extended-spectrum beta-lactamase OXA-163 -> OXA-48 family extended-spectrum class D beta-lactamase OXA-163 blaOXA-17 WP_032491804.1 product_name: OXA-10 family oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-17 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-17 blaOXA-18 WP_063861237.1 product_name: class D extended-spectrum beta-lactamase OXA-18 -> extended-spectrum class D beta-lactamase OXA-18 blaOXA-184 WP_002872405.1 product_name: class D beta-lactamase OXA-184 -> OXA-184 family class D beta-lactamase OXA-184 blaOXA-19 WP_063861309.1 product_name: OXA-10 family class D extended-spectrum beta-lactamase OXA-19 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-19 blaOXA-207 WP_057689930.1 pubmed_reference: -> 24890588 blaOXA-226 WP_063861826.1 product_name: OXA-2 family class D extended-spectrum beta-lactamase OXA-226 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-226 blaOXA-23 WP_001046004.1 product_name: carbapenem-hydrolyzing class D beta-lactamase OXA-23 -> OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-23 blaOXA-233 WP_063862149.1 pubmed_reference: -> 33382875 blaOXA-24 WP_012754353.1 product_name: carbapenem-hydrolyzing class D beta-lactamase OXA-24 -> OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-24 blaOXA-274 WP_004725235.1 product_name: class D beta-lactamase OXA-274 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-274 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-275 WP_004816501.1 product_name: OXA-274 family class D beta-lactamase OXA-275 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-275 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-28 WP_032489753.1 product_name: OXA-10 family class D extended-spectrum beta-lactamase OXA-28 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-28 blaOXA-286 WP_004657207.1 product_name: class D beta-lactamase OXA-286 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-286 pubmed_reference: -> 30247543 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-287 WP_032865068.1 product_name: OXA-286 family class D beta-lactamase OXA-287 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-287 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-288 WP_005201559.1 product_name: OXA-286 family class D beta-lactamase OXA-288 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-288 pubmed_reference: 24277043 -> 24277043,30247543 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-291 WP_005185807.1 product_name: OXA-286 family class D beta-lactamase OXA-291 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-291 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-292 WP_005209448.1 product_name: OXA-286 family class D beta-lactamase OXA-292 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-292 pubmed_reference: 24277043 -> 24277043,30247543 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-293 WP_032877719.1 product_name: OXA-286 family class D beta-lactamase OXA-293 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-293 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-302 WP_005238189.1 product_name: OXA-286 family class D beta-lactamase OXA-302 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-302 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-303 WP_005317413.1 product_name: OXA-286 family class D beta-lactamase OXA-303 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-303 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-306 WP_005297518.1 product_name: OXA-286 family class D beta-lactamase OXA-306 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-306 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-307 WP_032879257.1 product_name: OXA-286 family class D beta-lactamase OXA-307 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-307 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-31 WP_032490053.1 product_name: OXA-1 family class D extended-spectrum beta-lactamase OXA-31 -> OXA-1 family extended-spectrum class D beta-lactamase OXA-31 blaOXA-32 WP_063862613.1 product_name: OXA-2 family class D extended-spectrum beta-lactamase OXA-32 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-32 blaOXA-35 WP_063862720.1 product_name: OXA-10 family oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-35 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-35 blaOXA-364 WP_063862734.1 product_name: class D beta-lactamase OXA-364 -> OXA-364 family class D beta-lactamase OXA-364 blaOXA-372 WP_063862739.1 pubmed_reference: -> 26126492 blaOXA-405 WP_063862762.1 product_name: OXA-48 family class D extended-spectrum beta-lactamase OXA-405 -> OXA-48 family extended-spectrum class D beta-lactamase OXA-405 blaOXA-45 WP_032490761.1 product_name: oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-45 -> extended-spectrum class D beta-lactamase OXA-45 blaOXA-455 WP_054428802.1 product_name: OXA-364 family oxacillin-hydrolyzing class D beta-lactamase OXA-455 -> OXA-364 family class D beta-lactamase OXA-455 blaOXA-48 WP_015059991.1 product_name: carbapenem-hydrolyzing class D beta-lactamase OXA-48 -> OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-48 blaOXA-513 WP_063864194.1 product_name: OXA-364 family oxacillin-hydrolyzing class D beta-lactamase OXA-513 -> OXA-364 family class D beta-lactamase OXA-513 blaOXA-519 WP_094009808.1 pubmed_reference: -> 29866857 blaOXA-53 WP_063864223.1 product_name: OXA-2 family class D extended-spectrum beta-lactamase OXA-53 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-53 blaOXA-539 WP_071593233.1 product_name: OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-539 -> OXA-2 family inhibitor-resistant extended-spectrum class D beta-lactamase OXA-539 pubmed_reference: -> 28674059 blaOXA-653 WP_087554513.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-655 WP_122630842.1 pubmed_reference: -> 30397053 blaOXA-665 WP_016657654.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-666 WP_092689909.1 product_name: carbapenem-hydrolyzing class D beta-lactamase OXA-666 -> class D beta-lactamase OXA-666 pubmed_reference: -> 30247543 blaOXA-667 WP_096735335.1 product_name: OXA-274 family class D beta-lactamase OXA-667 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-667 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-668 WP_034612711.1 product_name: OXA-274 family class D beta-lactamase OXA-668 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-668 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-669 WP_056517622.1 product_name: OXA-274 family class D beta-lactamase OXA-669 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-669 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-670 WP_016651348.1 product_name: OXA-286 family class D beta-lactamase OXA-670 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-670 pubmed_reference: -> 30247543 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-671 WP_081401608.1 product_name: OXA-286 family class D beta-lactamase OXA-671 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-671 pubmed_reference: -> 30247543 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-672 WP_023271137.1 product_name: OXA-286 family class D beta-lactamase OXA-672 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-672 pubmed_reference: -> 30247543 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-673 WP_016162389.1 product_name: OXA-286 family class D beta-lactamase OXA-673 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-673 pubmed_reference: -> 30247543 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-674 WP_081406929.1 product_name: OXA-286 family class D beta-lactamase OXA-674 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-674 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-676 WP_122630858.1 product_name: OXA-10 family class D beta-lactamase OXA-676 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-676 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-679 WP_122634439.1 product_name: carbapenem-hydrolyzing class D beta-lactamase OXA-679 -> OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-679 pubmed_reference: -> 30844059 blaOXA-681 WP_122630881.1 product_name: OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-681 -> OXA-2 family inhibitor-resistant extended-spectrum class D beta-lactamase OXA-681 blaOXA-727 WP_114272532.1 product_name: class D beta-lactamase OXA-727 -> OXA-727 family class D beta-lactamase OXA-727 blaOXA-736 WP_122630855.1 product_name: OXA-10 family class D beta-lactamase OXA-736 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-736 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-806 WP_136512097.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-807 WP_136512098.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-808 WP_136512099.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-809 WP_136512100.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-810 WP_136512101.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-811 WP_136512102.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-812 WP_034688190.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-813 WP_005404206.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-814 WP_005405613.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-815 WP_111280830.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-816 WP_026444036.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-817 WP_075040046.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-818 WP_034670108.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-830 WP_152315468.1 product_name: class D extended-spectrum beta-lactamase OXA-830 -> extended-spectrum class D beta-lactamase OXA-830 blaOXA-893 WP_194293137.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-897 WP_164461290.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-911 WP_168247884.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-935 WP_141989064.1 product_name: OXA-10 family class D beta-lactamase OXA-935 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-935 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-966 WP_005405099.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-967 WP_231869594.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-968 WP_231869595.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-969 WP_231869596.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXY-1-1 WP_014228247.1 product_name: class A extended-spectrum beta-lactamase OXY-1-1 -> extended-spectrum class A beta-lactamase OXY-1-1 blaOXY-1-2 WP_025107110.1 product_name: class A extended-spectrum beta-lactamase OXY-1-2 -> extended-spectrum class A beta-lactamase OXY-1-2 blaOXY-1-3 WP_063864545.1 product_name: class A extended-spectrum beta-lactamase OXY-1-3 -> extended-spectrum class A beta-lactamase OXY-1-3 blaOXY-1-4 WP_049101515.1 product_name: class A extended-spectrum beta-lactamase OXY-1-4 -> extended-spectrum class A beta-lactamase OXY-1-4 blaOXY-1-6 WP_063864546.1 product_name: class A extended-spectrum beta-lactamase OXY-1-6 -> extended-spectrum class A beta-lactamase OXY-1-6 blaOXY-2-1 WP_032727905.1 product_name: class A extended-spectrum beta-lactamase OXY-2-1 -> extended-spectrum class A beta-lactamase OXY-2-1 blaOXY-2-10 WP_063864547.1 product_name: class A extended-spectrum beta-lactamase OXY-2-10 -> extended-spectrum class A beta-lactamase OXY-2-10 blaOXY-2-11 WP_004111091.1 product_name: class A extended-spectrum beta-lactamase OXY-2-11 -> extended-spectrum class A beta-lactamase OXY-2-11 blaOXY-2-12 WP_063864548.1 product_name: class A extended-spectrum beta-lactamase OXY-2-12 -> extended-spectrum class A beta-lactamase OXY-2-12 blaOXY-2-13 WP_063864549.1 product_name: class A extended-spectrum beta-lactamase OXY-2-13 -> extended-spectrum class A beta-lactamase OXY-2-13 blaOXY-2-14 WP_063842752.1 product_name: class A extended-spectrum beta-lactamase OXY-2-14 -> extended-spectrum class A beta-lactamase OXY-2-14 blaOXY-2-15 WP_063864550.1 product_name: class A extended-spectrum beta-lactamase OXY-2-15 -> extended-spectrum class A beta-lactamase OXY-2-15 blaOXY-2-2 WP_023329386.1 product_name: class A extended-spectrum beta-lactamase OXY-2-2 -> extended-spectrum class A beta-lactamase OXY-2-2 blaOXY-2-3 WP_063864551.1 product_name: class A extended-spectrum beta-lactamase OXY-2-3 -> extended-spectrum class A beta-lactamase OXY-2-3 blaOXY-2-4 WP_004099854.1 product_name: class A extended-spectrum beta-lactamase OXY-2-4 -> extended-spectrum class A beta-lactamase OXY-2-4 blaOXY-2-5 WP_063842759.1 product_name: class A extended-spectrum beta-lactamase OXY-2-5 -> extended-spectrum class A beta-lactamase OXY-2-5 blaOXY-2-6 WP_063864552.1 product_name: class A extended-spectrum beta-lactamase OXY-2-6 -> extended-spectrum class A beta-lactamase OXY-2-6 blaOXY-2-7 WP_017146441.1 product_name: class A extended-spectrum beta-lactamase OXY-2-7 -> extended-spectrum class A beta-lactamase OXY-2-7 blaOXY-2-8 WP_053064676.1 product_name: class A extended-spectrum beta-lactamase OXY-2-8 -> extended-spectrum class A beta-lactamase OXY-2-8 blaOXY-2-9 WP_063864553.1 product_name: class A extended-spectrum beta-lactamase OXY-2-9 -> extended-spectrum class A beta-lactamase OXY-2-9 blaOXY-3-1 WP_063864554.1 product_name: class A extended-spectrum beta-lactamase OXY-3-1 -> extended-spectrum class A beta-lactamase OXY-3-1 blaOXY-4-1 WP_004130122.1 product_name: class A extended-spectrum beta-lactamase OXY-4-1 -> extended-spectrum class A beta-lactamase OXY-4-1 blaOXY-5-1 WP_063864555.1 product_name: class A extended-spectrum beta-lactamase OXY-5-1 -> extended-spectrum class A beta-lactamase OXY-5-1 blaOXY-5-2 WP_009652647.1 product_name: class A extended-spectrum beta-lactamase OXY-5-2 -> extended-spectrum class A beta-lactamase OXY-5-2 blaOXY-6-1 WP_063864556.1 product_name: class A extended-spectrum beta-lactamase OXY-6-1 -> extended-spectrum class A beta-lactamase OXY-6-1 blaOXY-6-2 WP_063864557.1 product_name: class A extended-spectrum beta-lactamase OXY-6-2 -> extended-spectrum class A beta-lactamase OXY-6-2 blaOXY-6-3 WP_063864558.1 product_name: class A extended-spectrum beta-lactamase OXY-6-3 -> extended-spectrum class A beta-lactamase OXY-6-3 blaOXY-6-4 WP_004137840.1 product_name: class A extended-spectrum beta-lactamase OXY-6-4 -> extended-spectrum class A beta-lactamase OXY-6-4 blaPDC-2 WP_063864573.1 product_name: class C extended-spectrum beta-lactamase PDC-2 -> extended-spectrum class C beta-lactamase PDC-2 blaPDC-221 WP_100931731.1 pubmed_reference: 29149337 -> 29149337,34930034 blaPDC-223 WP_100931733.1 pubmed_reference: 29149337 -> 29149337,34930034 blaPDC-270 WP_109791203.1 pubmed_reference: -> 31636072 blaPDC-3 WP_003121934.1 product_name: class C extended-spectrum beta-lactamase PDC-3 -> extended-spectrum class C beta-lactamase PDC-3 blaPDC-4 WP_063864580.1 product_name: class C extended-spectrum beta-lactamase PDC-4 -> extended-spectrum class C beta-lactamase PDC-4 blaPDC-477 WP_213994605.1 product_name: class C beta-lactamase PDC-477 -> inhibitor-resistant class C beta-lactamase PDC-477 pubmed_reference: -> 34930034 blaPDC-478 WP_213994606.1 product_name: class C beta-lactamase PDC-478 -> inhibitor-resistant class C beta-lactamase PDC-478 pubmed_reference: -> 34930034 blaPDC-482 WP_213994610.1 product_name: class C beta-lactamase PDC-482 -> inhibitor-resistant class C beta-lactamase PDC-482 pubmed_reference: -> 34930034 blaPDC-483 WP_213994611.1 product_name: class C beta-lactamase PDC-483 -> inhibitor-resistant class C beta-lactamase PDC-483 pubmed_reference: -> 34930034 blaPDC-5 WP_003119095.1 product_name: class C extended-spectrum beta-lactamase PDC-5 -> extended-spectrum class C beta-lactamase PDC-5 blaPDC-500 WP_231873784.1 pubmed_reference: -> 31636072 blaPDC-510 WP_240067745.1 product_name: class C beta-lactamase PDC-510 -> inhibitor-resistant class C beta-lactamase PDC-510 pubmed_reference: -> 31636072 blaPER-1 WP_001100753.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase PER-1 -> inhibitor-resistant extended-spectrum class A beta-lactamase PER-1 blaPER-10 WP_001100752.1 product_name: class A extended-spectrum beta-lactamase PER-10 -> extended-spectrum class A beta-lactamase PER-10 blaPER-11 WP_104009831.1 product_name: class A extended-spectrum beta-lactamase PER-11 -> extended-spectrum class A beta-lactamase PER-11 blaPER-12 WP_096865225.1 product_name: class A extended-spectrum beta-lactamase PER-12 -> extended-spectrum class A beta-lactamase PER-12 blaPER-13 WP_136512105.1 product_name: class A extended-spectrum beta-lactamase PER-13 -> extended-spectrum class A beta-lactamase PER-13 blaPER-14 WP_156404659.1 product_name: class A extended-spectrum beta-lactamase PER-14 -> extended-spectrum class A beta-lactamase PER-14 blaPER-15 WP_168247906.1 product_name: class A extended-spectrum beta-lactamase PER-15 -> extended-spectrum class A beta-lactamase PER-15 blaPER-16 WP_202089433.1 product_name: class A extended-spectrum beta-lactamase PER-16 -> extended-spectrum class A beta-lactamase PER-16 blaPER-2 WP_032491907.1 product_name: class A extended-spectrum beta-lactamase PER-2 -> extended-spectrum class A beta-lactamase PER-2 pubmed_reference: 8851581 -> 17438050,8851581 blaPER-3 WP_049637349.1 product_name: class A extended-spectrum beta-lactamase PER-3 -> extended-spectrum class A beta-lactamase PER-3 pubmed_reference: 21968366 -> 21968366,26674256 blaPER-4 WP_063864593.1 product_name: class A extended-spectrum beta-lactamase PER-4 -> extended-spectrum class A beta-lactamase PER-4 blaPER-5 WP_063864594.1 product_name: class A extended-spectrum beta-lactamase PER-5 -> extended-spectrum class A beta-lactamase PER-5 blaPER-6 WP_063864595.1 product_name: class A extended-spectrum beta-lactamase PER-6 -> extended-spectrum class A beta-lactamase PER-6 blaPER-7 WP_032495440.1 product_name: class A extended-spectrum beta-lactamase PER-7 -> extended-spectrum class A beta-lactamase PER-7 blaPER-8 WP_063864596.1 product_name: class A extended-spectrum beta-lactamase PER-8 -> extended-spectrum class A beta-lactamase PER-8 blaPER-9 WP_063864597.1 product_name: class A extended-spectrum beta-lactamase PER-9 -> extended-spectrum class A beta-lactamase PER-9 blaPLA-1 WP_032699754.1 product_name: class A broad-spectrum beta-lactamase PLA-1 -> broad-spectrum class A beta-lactamase PLA-1 blaPME-1 WP_063864599.1 product_name: class A extended-spectrum beta-lactamase PME-1 -> extended-spectrum class A beta-lactamase PME-1 pubmed_reference: -> 21402845 subclass: BETA-LACTAM -> CEPHALOSPORIN blaRAHN-1 WP_063864600.1 product_name: class A extended-spectrum beta-lactamase RAHN-1 -> extended-spectrum class A beta-lactamase RAHN-1 blaRAHN-2 WP_063864601.1 product_name: class A extended-spectrum beta-lactamase RAHN-2 -> extended-spectrum class A beta-lactamase RAHN-2 blaRASA-1 WP_064964747.1 product_name: class A extended-spectrum beta-lactamase RASA-1 -> extended-spectrum class A beta-lactamase RASA-1 blaROB-1 WP_005618523.1 product_name: cephalosporin-hydrolyzing class A beta-lactamase ROB-1 -> broad-spectrum class A beta-lactamase ROB-1 blaROB-10 WP_116743769.1 product_name: class A beta-lactamase ROB-10 -> broad-spectrum class A beta-lactamase ROB-10 blaROB-11 WP_132995818.1 product_name: class A beta-lactamase ROB-11 -> broad-spectrum class A beta-lactamase ROB-11 blaROB-12 WP_213994612.1 product_name: class A beta-lactamase ROB-12 -> broad-spectrum class A beta-lactamase ROB-12 blaROB-13 WP_015431537.1 allele: blaROB-2 -> blaROB-13 hierarchy_node: blaROB-2 -> blaROB-13 product_name: class A beta-lactamase ROB-2 -> broad-spectrum class A beta-lactamase ROB-13 blaROB-2 WP_172693371.1 allele: blaROB-9 -> blaROB-2 hierarchy_node: blaROB-9 -> blaROB-2 product_name: class A beta-lactamase ROB-9 -> extended-spectrum class A beta-lactamase ROB-2 pubmed_reference: -> 30561662 blaROB-3 WP_075606311.1 product_name: class A beta-lactamase ROB-3 -> broad-spectrum class A beta-lactamase ROB-3 blaROB-4 WP_078318620.1 product_name: class A beta-lactamase ROB-4 -> broad-spectrum class A beta-lactamase ROB-4 blaROB-5 WP_103034696.1 product_name: class A beta-lactamase ROB-5 -> broad-spectrum class A beta-lactamase ROB-5 blaROB-6 WP_179284390.1 product_name: class A beta-lactamase ROB-6 -> broad-spectrum class A beta-lactamase ROB-6 blaROB-7 WP_179284391.1 product_name: class A beta-lactamase ROB-7 -> broad-spectrum class A beta-lactamase ROB-7 blaROB-8 WP_179284392.1 product_name: class A beta-lactamase ROB-8 -> broad-spectrum class A beta-lactamase ROB-8 blaRUB-1 WP_072186106.1 product_name: class A broad-spectrum beta-lactamase RUB-1 -> broad-spectrum class A beta-lactamase RUB-1 blaSED-1 WP_063864602.1 product_name: class A broad-spectrum beta-lactamase SED-1 -> broad-spectrum class A beta-lactamase SED-1 blaSFO-1 WP_032489477.1 product_name: class A extended-spectrum beta-lactamase SFO-1 -> extended-spectrum class A beta-lactamase SFO-1 blaSGM-1 WP_009821475.1 product_name: class A extended-spectrum beta-lactamase SGM-1 -> extended-spectrum class A beta-lactamase SGM-1 blaSHV-1 WP_001620095.1 product_name: class A broad-spectrum beta-lactamase SHV-1 -> broad-spectrum class A beta-lactamase SHV-1 blaSHV-100 WP_063864604.1 product_name: class A broad-spectrum beta-lactamase SHV-100 -> broad-spectrum class A beta-lactamase SHV-100 blaSHV-101 WP_063864605.1 product_name: class A broad-spectrum beta-lactamase SHV-101 -> broad-spectrum class A beta-lactamase SHV-101 blaSHV-102 WP_063864606.1 product_name: class A extended-spectrum beta-lactamase SHV-102 -> extended-spectrum class A beta-lactamase SHV-102 blaSHV-103 WP_063864607.1 product_name: class A broad-spectrum beta-lactamase SHV-103 -> broad-spectrum class A beta-lactamase SHV-103 blaSHV-104 WP_032492114.1 product_name: class A broad-spectrum beta-lactamase SHV-104 -> broad-spectrum class A beta-lactamase SHV-104 blaSHV-105 WP_063864608.1 product_name: class A extended-spectrum beta-lactamase SHV-105 -> extended-spectrum class A beta-lactamase SHV-105 blaSHV-106 WP_063864609.1 product_name: class A extended-spectrum beta-lactamase SHV-106 -> extended-spectrum class A beta-lactamase SHV-106 blaSHV-107 WP_063864610.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase SHV-107 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-107 blaSHV-108 WP_063864611.1 product_name: class A broad-spectrum beta-lactamase SHV-108 -> broad-spectrum class A beta-lactamase SHV-108 pubmed_reference: -> 11036038 blaSHV-109 WP_063864612.1 product_name: class A broad-spectrum beta-lactamase SHV-109 -> broad-spectrum class A beta-lactamase SHV-109 blaSHV-11 WP_004176269.1 product_name: class A broad-spectrum beta-lactamase SHV-11 -> broad-spectrum class A beta-lactamase SHV-11 blaSHV-111 WP_063864614.1 product_name: class A broad-spectrum beta-lactamase SHV-111 -> broad-spectrum class A beta-lactamase SHV-111 blaSHV-115 WP_156404661.1 product_name: class A extended-spectrum beta-lactamase SHV-115 -> extended-spectrum class A beta-lactamase SHV-115 pubmed_reference: -> 27656166 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-12 WP_002904004.1 product_name: class A extended-spectrum beta-lactamase SHV-12 -> extended-spectrum class A beta-lactamase SHV-12 blaSHV-120 WP_063864616.1 product_name: class A extended-spectrum beta-lactamase SHV-120 -> extended-spectrum class A beta-lactamase SHV-120 blaSHV-128 WP_063864618.1 product_name: class A extended-spectrum beta-lactamase SHV-128 -> extended-spectrum class A beta-lactamase SHV-128 blaSHV-129 WP_032494802.1 product_name: class A extended-spectrum beta-lactamase SHV-129 -> extended-spectrum class A beta-lactamase SHV-129 blaSHV-13 WP_063864619.1 product_name: class A extended-spectrum beta-lactamase SHV-13 -> extended-spectrum class A beta-lactamase SHV-13 blaSHV-133 WP_063864621.1 product_name: class A broad-spectrum beta-lactamase SHV-133 -> broad-spectrum class A beta-lactamase SHV-133 blaSHV-134 WP_063864622.1 product_name: class A extended-spectrum beta-lactamase SHV-134 -> extended-spectrum class A beta-lactamase SHV-134 blaSHV-135 WP_063864623.1 product_name: class A broad-spectrum beta-lactamase SHV-135 -> broad-spectrum class A beta-lactamase SHV-135 blaSHV-137 WP_063864624.1 product_name: class A broad-spectrum beta-lactamase SHV-137 -> broad-spectrum class A beta-lactamase SHV-137 blaSHV-14 WP_063864625.1 product_name: class A broad-spectrum beta-lactamase SHV-14 -> broad-spectrum class A beta-lactamase SHV-14 blaSHV-141 WP_063864626.1 product_name: class A broad-spectrum beta-lactamase SHV-141 -> broad-spectrum class A beta-lactamase SHV-141 blaSHV-142 WP_063864627.1 product_name: class A broad-spectrum beta-lactamase SHV-142 -> broad-spectrum class A beta-lactamase SHV-142 blaSHV-145 WP_063864630.1 product_name: class A broad-spectrum beta-lactamase SHV-145 -> broad-spectrum class A beta-lactamase SHV-145 blaSHV-147 WP_063864632.1 product_name: class A broad-spectrum beta-lactamase SHV-147 -> broad-spectrum class A beta-lactamase SHV-147 blaSHV-148 WP_063864633.1 product_name: class A broad-spectrum beta-lactamase SHV-148 -> broad-spectrum class A beta-lactamase SHV-148 blaSHV-149 WP_063864634.1 product_name: class A broad-spectrum beta-lactamase SHV-149 -> broad-spectrum class A beta-lactamase SHV-149 blaSHV-15 WP_063864635.1 product_name: class A extended-spectrum beta-lactamase SHV-15 -> extended-spectrum class A beta-lactamase SHV-15 blaSHV-150 WP_063864636.1 product_name: class A broad-spectrum beta-lactamase SHV-150 -> broad-spectrum class A beta-lactamase SHV-150 blaSHV-151 WP_063864637.1 product_name: class A broad-spectrum beta-lactamase SHV-151 -> broad-spectrum class A beta-lactamase SHV-151 blaSHV-152 WP_063864638.1 product_name: class A extended-spectrum beta-lactamase SHV-152 -> extended-spectrum class A beta-lactamase SHV-152 pubmed_reference: 23587957 -> 23587957,32284385 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-153 WP_063864639.1 product_name: class A extended-spectrum beta-lactamase SHV-153 -> extended-spectrum class A beta-lactamase SHV-153 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-154 WP_063864640.1 product_name: class A extended-spectrum beta-lactamase SHV-154 -> extended-spectrum class A beta-lactamase SHV-154 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-16 WP_063864646.1 product_name: class A extended-spectrum beta-lactamase SHV-16 -> extended-spectrum class A beta-lactamase SHV-16 blaSHV-160 WP_063864647.1 product_name: class A extended-spectrum beta-lactamase SHV-160 -> extended-spectrum class A beta-lactamase SHV-160 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-161 WP_063864648.1 product_name: class A broad-spectrum beta-lactamase SHV-161 -> broad-spectrum class A beta-lactamase SHV-161 blaSHV-162 WP_063864649.1 product_name: class A extended-spectrum beta-lactamase SHV-162 -> extended-spectrum class A beta-lactamase SHV-162 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-163 WP_063864650.1 product_name: class A extended-spectrum beta-lactamase SHV-163 -> extended-spectrum class A beta-lactamase SHV-163 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-164 WP_063864651.1 product_name: class A broad-spectrum beta-lactamase SHV-164 -> broad-spectrum class A beta-lactamase SHV-164 blaSHV-165 WP_063864652.1 product_name: class A extended-spectrum beta-lactamase SHV-165 -> extended-spectrum class A beta-lactamase SHV-165 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-171 WP_070984444.1 product_name: class A broad-spectrum beta-lactamase SHV-171 -> broad-spectrum class A beta-lactamase SHV-171 blaSHV-179 WP_063864657.1 product_name: class A broad-spectrum beta-lactamase SHV-179 -> broad-spectrum class A beta-lactamase SHV-179 blaSHV-18 WP_063864658.1 product_name: class A extended-spectrum beta-lactamase SHV-18 -> extended-spectrum class A beta-lactamase SHV-18 blaSHV-183 WP_063864661.1 product_name: class A extended-spectrum beta-lactamase SHV-183 -> extended-spectrum class A beta-lactamase SHV-183 blaSHV-185 WP_063864662.1 product_name: class A broad-spectrum beta-lactamase SHV-185 -> broad-spectrum class A beta-lactamase SHV-185 blaSHV-187 WP_021440083.1 product_name: class A broad-spectrum beta-lactamase SHV-187 -> extended-spectrum class A beta-lactamase SHV-187 pubmed_reference: -> 34248878 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-189 WP_063864665.1 product_name: class A broad-spectrum beta-lactamase SHV-189 -> broad-spectrum class A beta-lactamase SHV-189 blaSHV-2 WP_012477587.1 product_name: class A extended-spectrum beta-lactamase SHV-2 -> extended-spectrum class A beta-lactamase SHV-2 blaSHV-229 WP_223146982.1 product_name: class A broad-spectrum beta-lactamase SHV-229 -> broad-spectrum class A beta-lactamase SHV-229 blaSHV-24 WP_063864670.1 product_name: class A extended-spectrum beta-lactamase SHV-24 -> extended-spectrum class A beta-lactamase SHV-24 blaSHV-25 WP_063864671.1 product_name: class A broad-spectrum beta-lactamase SHV-25 -> broad-spectrum class A beta-lactamase SHV-25 blaSHV-26 WP_023280043.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase SHV-26 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-26 blaSHV-27 WP_023282555.1 product_name: class A broad-spectrum beta-lactamase SHV-27 -> broad-spectrum class A beta-lactamase SHV-27 blaSHV-28 WP_004179754.1 product_name: class A broad-spectrum beta-lactamase SHV-28 -> broad-spectrum class A beta-lactamase SHV-28 blaSHV-29 WP_063864672.1 product_name: class extended-spectrum A beta-lactamase SHV-29 -> extended-spectrum class A beta-lactamase SHV-29 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-2A WP_032488413.1 product_name: class A extended-spectrum beta-lactamase SHV-2a -> extended-spectrum class A beta-lactamase SHV-2a blaSHV-3 WP_063864673.1 product_name: class A extended-spectrum beta-lactamase SHV-3 -> extended-spectrum class A beta-lactamase SHV-3 blaSHV-30 WP_032491180.1 product_name: class A extended-spectrum beta-lactamase SHV-30 -> extended-spectrum class A beta-lactamase SHV-30 blaSHV-31 WP_063864674.1 product_name: class A extended-spectrum beta-lactamase SHV-31 -> extended-spectrum class A beta-lactamase SHV-31 blaSHV-32 WP_063864675.1 product_name: class A broad-spectrum beta-lactamase SHV-32 -> broad-spectrum class A beta-lactamase SHV-32 blaSHV-33 WP_023325206.1 product_name: class A broad-spectrum beta-lactamase SHV-33 -> broad-spectrum class A beta-lactamase SHV-33 blaSHV-34 WP_063864676.1 product_name: class A extended-spectrum beta-lactamase SHV-34 -> extended-spectrum class A beta-lactamase SHV-34 blaSHV-36 WP_063864678.1 product_name: class A broad-spectrum beta-lactamase SHV-36 -> broad-spectrum class A beta-lactamase SHV-36 blaSHV-38 WP_063864680.1 product_name: class A extended-spectrum beta-lactamase SHV-38 -> extended-spectrum class A beta-lactamase SHV-38 blaSHV-4 WP_152330890.1 product_name: class A extended-spectrum beta-lactamase SHV-4 -> extended-spectrum class A beta-lactamase SHV-4 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-40 WP_063864681.1 product_name: class A broad-spectrum beta-lactamase SHV-40 -> broad-spectrum class A beta-lactamase SHV-40 blaSHV-41 WP_063864682.1 product_name: class A broad-spectrum beta-lactamase SHV-41 -> broad-spectrum class A beta-lactamase SHV-41 blaSHV-42 WP_063864683.1 product_name: class A broad-spectrum beta-lactamase SHV-42 -> broad-spectrum class A beta-lactamase SHV-42 blaSHV-43 WP_032490193.1 product_name: class A broad-spectrum beta-lactamase SHV-43 -> broad-spectrum class A beta-lactamase SHV-43 blaSHV-44 WP_063864684.1 product_name: class A broad-spectrum beta-lactamase SHV-44 -> broad-spectrum class A beta-lactamase SHV-44 blaSHV-45 WP_063864685.1 product_name: class A extended-spectrum beta-lactamase SHV-45 -> extended-spectrum class A beta-lactamase SHV-45 pubmed_reference: -> 26322883 blaSHV-46 WP_063864686.1 product_name: class A extended-spectrum beta-lactamase SHV-46 -> extended-spectrum class A beta-lactamase SHV-46 blaSHV-48 WP_063864687.1 product_name: class A broad-spectrum beta-lactamase SHV-48 -> broad-spectrum class A beta-lactamase SHV-48 blaSHV-49 WP_063864688.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase SHV-49 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-49 blaSHV-5 WP_011117369.1 product_name: class A extended-spectrum beta-lactamase SHV-5 -> extended-spectrum class A beta-lactamase SHV-5 blaSHV-50 WP_063864689.1 product_name: class A broad-spectrum beta-lactamase SHV-50 -> broad-spectrum class A beta-lactamase SHV-50 blaSHV-51 WP_063864690.1 product_name: class A broad-spectrum beta-lactamase SHV-51 -> broad-spectrum class A beta-lactamase SHV-51 blaSHV-52 WP_063864691.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase SHV-52 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-52 blaSHV-55 WP_063864692.1 product_name: class A extended-spectrum beta-lactamase SHV-55 -> extended-spectrum class A beta-lactamase SHV-55 blaSHV-56 WP_063864693.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase SHV-56 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-56 blaSHV-57 WP_032490632.1 product_name: class A extended-spectrum beta-lactamase SHV-57 -> extended-spectrum class A beta-lactamase SHV-57 blaSHV-59 WP_063864694.1 product_name: class A broad-spectrum beta-lactamase SHV-59 -> broad-spectrum class A beta-lactamase SHV-59 pubmed_reference: -> 33507142 blaSHV-60 WP_004183952.1 product_name: class A broad-spectrum beta-lactamase SHV-60 -> broad-spectrum class A beta-lactamase SHV-60 blaSHV-61 WP_063864695.1 product_name: class A broad-spectrum beta-lactamase SHV-61 -> broad-spectrum class A beta-lactamase SHV-61 blaSHV-62 WP_063864696.1 product_name: class A broad-spectrum beta-lactamase SHV-62 -> broad-spectrum class A beta-lactamase SHV-62 blaSHV-63 WP_063864697.1 product_name: class A broad-spectrum beta-lactamase SHV-63 -> broad-spectrum class A beta-lactamase SHV-63 blaSHV-64 WP_063864698.1 product_name: class A extended-spectrum beta-lactamase SHV-64 -> extended-spectrum class A beta-lactamase SHV-64 blaSHV-65 WP_063864699.1 product_name: class A extended-spectrum beta-lactamase SHV-65 -> extended-spectrum class A beta-lactamase SHV-65 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-66 WP_063864700.1 product_name: class A extended-spectrum beta-lactamase SHV-66 -> extended-spectrum class A beta-lactamase SHV-66 blaSHV-7 WP_020316986.1 product_name: class A extended-spectrum beta-lactamase SHV-7 -> extended-spectrum class A beta-lactamase SHV-7 blaSHV-70 WP_032491403.1 product_name: class A extended-spectrum beta-lactamase SHV-70 -> extended-spectrum class A beta-lactamase SHV-70 blaSHV-71 WP_063864703.1 product_name: class A broad-spectrum beta-lactamase SHV-71 -> broad-spectrum class A beta-lactamase SHV-71 blaSHV-72 WP_063864704.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase SHV-72 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-72 blaSHV-73 WP_063864705.1 product_name: class A broad-spectrum beta-lactamase SHV-73 -> broad-spectrum class A beta-lactamase SHV-73 blaSHV-74 WP_063864706.1 product_name: class A broad-spectrum beta-lactamase SHV-74 -> broad-spectrum class A beta-lactamase SHV-74 blaSHV-75 WP_023316270.1 product_name: class A broad-spectrum beta-lactamase SHV-75 -> broad-spectrum class A beta-lactamase SHV-75 blaSHV-76 WP_023158217.1 product_name: class A broad-spectrum beta-lactamase SHV-76 -> broad-spectrum class A beta-lactamase SHV-76 blaSHV-77 WP_063864707.1 product_name: class A broad-spectrum beta-lactamase SHV-77 -> broad-spectrum class A beta-lactamase SHV-77 blaSHV-78 WP_063864708.1 product_name: class A broad-spectrum beta-lactamase SHV-78 -> broad-spectrum class A beta-lactamase SHV-78 blaSHV-79 WP_063864709.1 product_name: class A broad-spectrum beta-lactamase SHV-79 -> broad-spectrum class A beta-lactamase SHV-79 blaSHV-8 WP_063864710.1 product_name: class A extended-spectrum beta-lactamase SHV-8 -> extended-spectrum class A beta-lactamase SHV-8 blaSHV-80 WP_023316831.1 product_name: class A broad-spectrum beta-lactamase SHV-80 -> broad-spectrum class A beta-lactamase SHV-80 blaSHV-81 WP_063864711.1 product_name: class A broad-spectrum beta-lactamase SHV-81 -> broad-spectrum class A beta-lactamase SHV-81 blaSHV-82 WP_063864712.1 product_name: class A broad-spectrum beta-lactamase SHV-82 -> broad-spectrum class A beta-lactamase SHV-82 blaSHV-85 WP_063864713.1 product_name: class A broad-spectrum beta-lactamase SHV-85 -> broad-spectrum class A beta-lactamase SHV-85 blaSHV-86 WP_063864714.1 product_name: class A extended-spectrum beta-lactamase SHV-86 -> extended-spectrum class A beta-lactamase SHV-86 blaSHV-89 WP_032491601.1 product_name: class A broad-spectrum beta-lactamase SHV-89 -> broad-spectrum class A beta-lactamase SHV-89 blaSHV-9 WP_032488887.1 product_name: class A extended-spectrum beta-lactamase SHV-9 -> extended-spectrum class A beta-lactamase SHV-9 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-92 WP_032491784.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase SHV-92 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-92 blaSHV-95 WP_063864717.1 product_name: class A broad-spectrum beta-lactamase SHV-95 -> broad-spectrum class A beta-lactamase SHV-95 blaSHV-97 WP_063864719.1 product_name: class A extended-spectrum beta-lactamase SHV-97 -> extended-spectrum class A beta-lactamase SHV-97 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-98 WP_063864720.1 product_name: class A broad-spectrum beta-lactamase SHV-98 -> broad-spectrum class A beta-lactamase SHV-98 blaSHV-99 WP_063864721.1 product_name: class A broad-spectrum beta-lactamase SHV-99 -> broad-spectrum class A beta-lactamase SHV-99 blaSPR-1 WP_012145975.1 pubmed_reference: -> 23982345 blaSPU-1 WP_063864748.1 product_name: CSP family class A extended-spectrum beta-lactamase SPU-1 -> CSP family extended-spectrum class A beta-lactamase SPU-1 blaSRT-1 WP_063864749.1 product_name: class C extended-spectrum beta-lactamase SRT-1 -> extended-spectrum class C beta-lactamase SRT-1 pubmed_reference: 8540730 -> 8540730,9449282 blaSST-1 WP_063864750.1 pubmed_reference: -> 9449282 blaTEM-1 WP_000027057.1 product_name: class A broad-spectrum beta-lactamase TEM-1 -> broad-spectrum class A beta-lactamase TEM-1 blaTEM-10 WP_000027061.1 product_name: class A extended-spectrum beta-lactamase TEM-10 -> extended-spectrum class A beta-lactamase TEM-10 blaTEM-101 WP_063864793.1 product_name: class A extended-spectrum beta-lactamase TEM-101 -> extended-spectrum class A beta-lactamase TEM-101 blaTEM-102 WP_063864794.1 product_name: class A extended-spectrum beta-lactamase TEM-102 -> extended-spectrum class A beta-lactamase TEM-102 blaTEM-103 WP_094353585.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-103 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-103 blaTEM-106 WP_063864796.1 product_name: class A extended-spectrum beta-lactamase TEM-106 -> extended-spectrum class A beta-lactamase TEM-106 blaTEM-107 WP_063864797.1 product_name: class A extended-spectrum beta-lactamase TEM-107 -> extended-spectrum class A beta-lactamase TEM-107 blaTEM-109 WP_063864799.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase TEM-109 -> inhibitor-resistant extended-spectrum class A beta-lactamase TEM-109 blaTEM-11 WP_063864800.1 product_name: class A extended-spectrum beta-lactamase TEM-11 -> extended-spectrum class A beta-lactamase TEM-11 blaTEM-110 WP_032494237.1 product_name: class A broad-spectrum beta-lactamase TEM-110 -> broad-spectrum class A beta-lactamase TEM-110 blaTEM-112 WP_063864802.1 product_name: class A extended-spectrum beta-lactamase TEM-112 -> extended-spectrum class A beta-lactamase TEM-112 blaTEM-113 WP_063864803.1 product_name: class A extended-spectrum beta-lactamase TEM-113 -> extended-spectrum class A beta-lactamase TEM-113 blaTEM-114 WP_063864804.1 product_name: class A extended-spectrum beta-lactamase TEM-114 -> extended-spectrum class A beta-lactamase TEM-114 blaTEM-115 WP_063864805.1 product_name: class A extended-spectrum beta-lactamase TEM-115 -> extended-spectrum class A beta-lactamase TEM-115 blaTEM-116 WP_000027050.1 product_name: class A broad-spectrum beta-lactamase TEM-116 -> broad-spectrum class A beta-lactamase TEM-116 blaTEM-12 WP_042065300.1 product_name: class A extended-spectrum beta-lactamase TEM-12 -> extended-spectrum class A beta-lactamase TEM-12 blaTEM-120 WP_063864806.1 product_name: class A extended-spectrum beta-lactamase TEM-120 -> extended-spectrum class A beta-lactamase TEM-120 blaTEM-121 WP_063864807.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase TEM-121 -> inhibitor-resistant extended-spectrum class A beta-lactamase TEM-121 blaTEM-122 WP_063864808.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-122 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-122 blaTEM-123 WP_063864809.1 product_name: class A extended-spectrum beta-lactamase TEM-123 -> extended-spectrum class A beta-lactamase TEM-123 blaTEM-124 WP_063864810.1 product_name: class A extended-spectrum beta-lactamase TEM-124 -> extended-spectrum class A beta-lactamase TEM-124 blaTEM-125 WP_063864811.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase TEM-125 -> inhibitor-resistant extended-spectrum class A beta-lactamase TEM-125 blaTEM-126 WP_063864819.1 product_name: class A extended-spectrum beta-lactamase TEM-126 -> extended-spectrum class A beta-lactamase TEM-126 blaTEM-127 WP_032490959.1 product_name: class A broad-spectrum beta-lactamase TEM-127 -> broad-spectrum class A beta-lactamase TEM-127 blaTEM-128 WP_032490960.1 product_name: class A broad-spectrum beta-lactamase TEM-128 -> broad-spectrum class A beta-lactamase TEM-128 blaTEM-129 WP_063864833.1 product_name: class A extended-spectrum beta-lactamase TEM-129 -> extended-spectrum class A beta-lactamase TEM-129 blaTEM-130 WP_063864843.1 product_name: class A extended-spectrum beta-lactamase TEM-130 -> extended-spectrum class A beta-lactamase TEM-130 pubmed_reference: -> 20138476 blaTEM-131 WP_063864850.1 product_name: class A extended-spectrum beta-lactamase TEM-131 -> extended-spectrum class A beta-lactamase TEM-131 blaTEM-132 WP_032490956.1 product_name: class A extended-spectrum beta-lactamase TEM-132 -> extended-spectrum class A beta-lactamase TEM-132 blaTEM-133 WP_063864851.1 product_name: class A extended-spectrum beta-lactamase TEM-133 -> extended-spectrum class A beta-lactamase TEM-133 blaTEM-134 WP_063864852.1 product_name: class A extended-spectrum beta-lactamase TEM-134 -> extended-spectrum class A beta-lactamase TEM-134 blaTEM-135 WP_015058868.1 product_name: class A broad-spectrum beta-lactamase TEM-135 -> broad-spectrum class A beta-lactamase TEM-135 blaTEM-136 WP_063864853.1 product_name: class A extended-spectrum beta-lactamase TEM-136 -> extended-spectrum class A beta-lactamase TEM-136 blaTEM-137 WP_063864854.1 product_name: class A extended-spectrum beta-lactamase TEM-137 -> extended-spectrum class A beta-lactamase TEM-137 blaTEM-138 WP_032491283.1 product_name: class A extended-spectrum beta-lactamase TEM-138 -> extended-spectrum class A beta-lactamase TEM-138 blaTEM-139 WP_032491449.1 product_name: class A extended-spectrum beta-lactamase TEM-139 -> extended-spectrum class A beta-lactamase TEM-139 blaTEM-141 WP_032491376.1 product_name: class A broad-spectrum beta-lactamase TEM-141 -> broad-spectrum class A beta-lactamase TEM-141 blaTEM-143 WP_063864856.1 product_name: class A extended-spectrum beta-lactamase TEM-143 -> extended-spectrum class A beta-lactamase TEM-143 blaTEM-144 WP_021598056.1 product_name: class A extended-spectrum beta-lactamase TEM-144 -> extended-spectrum class A beta-lactamase TEM-144 blaTEM-145 WP_063864857.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-145 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-145 blaTEM-147 WP_063864859.1 product_name: class A extended-spectrum beta-lactamase TEM-147 -> extended-spectrum class A beta-lactamase TEM-147 blaTEM-149 WP_063864860.1 product_name: class A extended-spectrum beta-lactamase TEM-149 -> extended-spectrum class A beta-lactamase TEM-149 blaTEM-15 WP_032492108.1 product_name: class A extended-spectrum beta-lactamase TEM-15 -> extended-spectrum class A beta-lactamase TEM-15 blaTEM-151 WP_063864862.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase TEM-151 -> inhibitor-resistant extended-spectrum class A beta-lactamase TEM-151 blaTEM-152 WP_063864863.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase TEM-152 -> inhibitor-resistant extended-spectrum class A beta-lactamase TEM-152 blaTEM-153 WP_063864864.1 product_name: class A extended-spectrum beta-lactamase TEM-153 -> extended-spectrum class A beta-lactamase TEM-153 blaTEM-154 WP_063864865.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase TEM-154 -> inhibitor-resistant extended-spectrum class A beta-lactamase TEM-154 blaTEM-155 WP_063864866.1 product_name: class A extended-spectrum beta-lactamase TEM-155 -> extended-spectrum class A beta-lactamase TEM-155 blaTEM-157 WP_063864867.1 product_name: class A extended-spectrum beta-lactamase TEM-157 -> extended-spectrum class A beta-lactamase TEM-157 blaTEM-158 WP_063864868.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase TEM-158 -> inhibitor-resistant extended-spectrum class A beta-lactamase TEM-158 blaTEM-159 WP_063864869.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-159 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-159 blaTEM-16 WP_063864870.1 product_name: class A extended-spectrum beta-lactamase TEM-16 -> extended-spectrum class A beta-lactamase TEM-16 blaTEM-160 WP_063864871.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-160 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-160 blaTEM-163 WP_063864873.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-163 -> broad-spectrum class A beta-lactamase TEM-163 pubmed_reference: -> 25444130 blaTEM-164 WP_032492113.1 product_name: class A extended-spectrum beta-lactamase TEM-164 -> extended-spectrum class A beta-lactamase TEM-164 blaTEM-167 WP_063864875.1 product_name: class A extended-spectrum beta-lactamase TEM-167 -> extended-spectrum class A beta-lactamase TEM-167 pubmed_reference: -> 27672380 blaTEM-168 WP_063864876.1 product_name: class A extended-spectrum beta-lactamase TEM-168 -> extended-spectrum class A beta-lactamase TEM-168 blaTEM-169 WP_060615518.1 product_name: class A extended-spectrum beta-lactamase TEM-169 -> extended-spectrum class A beta-lactamase TEM-169 blaTEM-17 WP_063864877.1 product_name: class A extended-spectrum beta-lactamase TEM-17 -> extended-spectrum class A beta-lactamase TEM-17 blaTEM-177 WP_063864878.1 product_name: class A extended-spectrum beta-lactamase TEM-177 -> extended-spectrum class A beta-lactamase TEM-177 blaTEM-178 WP_063864879.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase TEM-178 -> inhibitor-resistant extended-spectrum class A beta-lactamase TEM-178 blaTEM-182 WP_063864880.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-182 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-182 blaTEM-183 WP_063864881.1 product_name: class A broad-spectrum beta-lactamase TEM-183 -> broad-spectrum class A beta-lactamase TEM-183 blaTEM-184 WP_063864882.1 product_name: class A extended-spectrum beta-lactamase TEM-184 -> extended-spectrum class A beta-lactamase TEM-184 pubmed_reference: -> 29941651 blaTEM-185 WP_063864883.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-185 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-185 blaTEM-186 WP_063864884.1 product_name: class A broad-spectrum beta-lactamase TEM-186 -> broad-spectrum class A beta-lactamase TEM-186 blaTEM-187 WP_032494853.1 product_name: class A extended-spectrum beta-lactamase TEM-187 -> extended-spectrum class A beta-lactamase TEM-187 blaTEM-188 WP_063864885.1 product_name: class A extended-spectrum beta-lactamase TEM-188 -> extended-spectrum class A beta-lactamase TEM-188 blaTEM-19 WP_033560332.1 product_name: class A extended-spectrum beta-lactamase TEM-19 -> extended-spectrum class A beta-lactamase TEM-19 blaTEM-191 WP_077064889.1 product_name: class A extended-spectrum beta-lactamase TEM-191 -> extended-spectrum class A beta-lactamase TEM-191 blaTEM-197 WP_063864891.1 product_name: class A extended-spectrum beta-lactamase TEM-197 -> extended-spectrum class A beta-lactamase TEM-197 blaTEM-2 WP_011645017.1 product_name: class A broad-spectrum beta-lactamase TEM-2 -> broad-spectrum class A beta-lactamase TEM-2 blaTEM-20 WP_063864893.1 product_name: class A extended-spectrum beta-lactamase TEM-20 -> extended-spectrum class A beta-lactamase TEM-20 blaTEM-206 WP_040197984.1 product_name: class A broad-spectrum beta-lactamase TEM-206 -> broad-spectrum class A beta-lactamase TEM-206 blaTEM-207 WP_063864896.1 product_name: class A extended-spectrum beta-lactamase TEM-207 -> extended-spectrum class A beta-lactamase TEM-207 blaTEM-21 WP_063864899.1 product_name: class A extended-spectrum beta-lactamase TEM-21 -> extended-spectrum class A beta-lactamase TEM-21 blaTEM-211 WP_063864900.1 product_name: class A extended-spectrum beta-lactamase TEM-211 -> extended-spectrum class A beta-lactamase TEM-211 blaTEM-22 WP_063864906.1 product_name: class A extended-spectrum beta-lactamase TEM-22 -> extended-spectrum class A beta-lactamase TEM-22 blaTEM-236 WP_116786831.1 product_name: class A extended-spectrum beta-lactamase TEM-236 -> extended-spectrum class A beta-lactamase TEM-236 blaTEM-24 WP_015365452.1 product_name: class A extended-spectrum beta-lactamase TEM-24 -> extended-spectrum class A beta-lactamase TEM-24 blaTEM-26 WP_047028173.1 product_name: class A extended-spectrum beta-lactamase TEM-26 -> extended-spectrum class A beta-lactamase TEM-26 blaTEM-28 WP_063864909.1 product_name: class A extended-spectrum beta-lactamase TEM-28 -> extended-spectrum class A beta-lactamase TEM-28 blaTEM-29 WP_032490103.1 product_name: class A extended-spectrum beta-lactamase TEM-29 -> extended-spectrum class A beta-lactamase TEM-29 blaTEM-3 WP_032488414.1 product_name: class A extended-spectrum beta-lactamase TEM-3 -> extended-spectrum class A beta-lactamase TEM-3 blaTEM-30 WP_021561477.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-30 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-30 blaTEM-31 WP_165539487.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-31 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-31 blaTEM-32 WP_052944427.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-32 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-32 blaTEM-33 WP_013279314.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-33 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-33 blaTEM-34 WP_015379489.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-34 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-34 blaTEM-35 WP_063864910.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-35 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-35 blaTEM-36 WP_075985685.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-36 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-36 blaTEM-37 WP_159373457.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-37 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-37 blaTEM-39 WP_148044474.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-39 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-39 blaTEM-4 WP_063864911.1 product_name: class A extended-spectrum beta-lactamase TEM-4 -> extended-spectrum class A beta-lactamase TEM-4 blaTEM-40 WP_021526512.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-40 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-40 blaTEM-43 WP_063864912.1 product_name: class A extended-spectrum beta-lactamase TEM-43 -> extended-spectrum class A beta-lactamase TEM-43 blaTEM-45 WP_063864913.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-45 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-45 blaTEM-47 WP_063864914.1 product_name: class A extended-spectrum beta-lactamase TEM-47 -> extended-spectrum class A beta-lactamase TEM-47 blaTEM-48 WP_063864915.1 product_name: class A extended-spectrum beta-lactamase TEM-48 -> extended-spectrum class A beta-lactamase TEM-48 blaTEM-49 WP_063864916.1 product_name: class A extended-spectrum beta-lactamase TEM-49 -> extended-spectrum class A beta-lactamase TEM-49 blaTEM-5 WP_109963600.1 product_name: class A extended-spectrum beta-lactamase TEM-5 -> extended-spectrum class A beta-lactamase TEM-5 blaTEM-52 WP_015058977.1 product_name: class A extended-spectrum beta-lactamase TEM-52 -> extended-spectrum class A beta-lactamase TEM-52 blaTEM-53 WP_063864923.1 product_name: class A extended-spectrum beta-lactamase TEM-53 -> extended-spectrum class A beta-lactamase TEM-53 blaTEM-54 WP_063864930.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-54 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-54 blaTEM-55 WP_063864938.1 product_name: class A broad-spectrum beta-lactamase TEM-55 -> broad-spectrum class A beta-lactamase TEM-55 blaTEM-57 WP_032492330.1 product_name: class A broad-spectrum beta-lactamase TEM-57 -> broad-spectrum class A beta-lactamase TEM-57 blaTEM-6 WP_063864949.1 product_name: class A extended-spectrum beta-lactamase TEM-6 -> extended-spectrum class A beta-lactamase TEM-6 blaTEM-60 WP_032489150.1 product_name: class A extended-spectrum beta-lactamase TEM-60 -> extended-spectrum class A beta-lactamase TEM-60 blaTEM-61 WP_188240090.1 product_name: class A extended-spectrum beta-lactamase TEM-61 -> extended-spectrum class A beta-lactamase TEM-61 blaTEM-63 WP_055314004.1 product_name: class A extended-spectrum beta-lactamase TEM-63 -> extended-spectrum class A beta-lactamase TEM-63 blaTEM-67 WP_032490504.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-67 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-67 blaTEM-68 WP_032489741.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase TEM-68 -> inhibitor-resistant extended-spectrum class A beta-lactamase TEM-68 blaTEM-7 WP_109874025.1 product_name: class A extended-spectrum beta-lactamase TEM-7 -> extended-spectrum class A beta-lactamase TEM-7 blaTEM-71 WP_032490155.1 product_name: class A extended-spectrum beta-lactamase TEM-71 -> extended-spectrum class A beta-lactamase TEM-71 blaTEM-72 WP_032489614.1 product_name: class A extended-spectrum beta-lactamase TEM-72 -> extended-spectrum class A beta-lactamase TEM-72 blaTEM-76 WP_063864990.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-76 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-76 blaTEM-77 WP_063864996.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-77 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-77 blaTEM-78 WP_063865003.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-78 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-78 blaTEM-79 WP_063865008.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-79 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-79 blaTEM-8 WP_063865014.1 product_name: class A extended-spectrum beta-lactamase TEM-8 -> extended-spectrum class A beta-lactamase TEM-8 blaTEM-80 WP_063865024.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-80 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-80 blaTEM-81 WP_063865030.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-81 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-81 blaTEM-82 WP_063865036.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-82 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-82 blaTEM-83 WP_063865043.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-83 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-83 blaTEM-84 WP_063865053.1 product_name: inhibitor-resistant class A broad-spectrum beta-lactamase TEM-84 -> inhibitor-resistant broad-spectrum class A beta-lactamase TEM-84 blaTEM-85 WP_032490101.1 product_name: class A extended-spectrum beta-lactamase TEM-85 -> extended-spectrum class A beta-lactamase TEM-85 blaTEM-86 WP_032490102.1 product_name: class A extended-spectrum beta-lactamase TEM-86 -> extended-spectrum class A beta-lactamase TEM-86 blaTEM-87 WP_032489893.1 product_name: class A extended-spectrum beta-lactamase TEM-87 -> extended-spectrum class A beta-lactamase TEM-87 blaTEM-88 WP_032489980.1 product_name: class A extended-spectrum beta-lactamase TEM-88 -> extended-spectrum class A beta-lactamase TEM-88 blaTEM-9 WP_102607453.1 product_name: class A extended-spectrum beta-lactamase TEM-9 -> extended-spectrum class A beta-lactamase TEM-9 blaTEM-90 WP_032490026.1 product_name: class A broad-spectrum beta-lactamase TEM-90 -> broad-spectrum class A beta-lactamase TEM-90 blaTEM-91 WP_063865088.1 product_name: class A extended-spectrum beta-lactamase TEM-91 -> extended-spectrum class A beta-lactamase TEM-91 blaTEM-92 WP_063865103.1 product_name: class A extended-spectrum beta-lactamase TEM-92 -> extended-spectrum class A beta-lactamase TEM-92 blaTEM-93 WP_032490317.1 product_name: class A extended-spectrum beta-lactamase TEM-93 -> extended-spectrum class A beta-lactamase TEM-93 blaTEM-94 WP_032490318.1 product_name: class A extended-spectrum beta-lactamase TEM-94 -> extended-spectrum class A beta-lactamase TEM-94 blaTEM-95 WP_061659705.1 product_name: class A broad-spectrum beta-lactamase TEM-95 -> broad-spectrum class A beta-lactamase TEM-95 blaTLA-1 WP_032494759.1 product_name: class A extended-spectrum beta-lactamase TLA-1 -> extended-spectrum class A beta-lactamase TLA-1 blaTLA-2 WP_011222052.1 product_name: class A extended-spectrum beta-lactamase TLA-2 -> extended-spectrum class A beta-lactamase TLA-2 blaTLA-3 WP_059512353.1 product_name: class A extended-spectrum beta-lactamase TLA-3 -> extended-spectrum class A beta-lactamase TLA-3 blaVEB-1 WP_000706731.1 product_name: class A extended-spectrum beta-lactamase VEB-1 -> extended-spectrum class A beta-lactamase VEB-1 blaVEB-10 WP_063865150.1 product_name: class A extended-spectrum beta-lactamase VEB-10 -> extended-spectrum class A beta-lactamase VEB-10 blaVEB-11 WP_063865151.1 product_name: class A extended-spectrum beta-lactamase VEB-11 -> extended-spectrum class A beta-lactamase VEB-11 blaVEB-12 WP_063865152.1 product_name: class A extended-spectrum beta-lactamase VEB-12 -> extended-spectrum class A beta-lactamase VEB-12 blaVEB-13 WP_063865153.1 product_name: class A extended-spectrum beta-lactamase VEB-13 -> extended-spectrum class A beta-lactamase VEB-13 blaVEB-14 WP_063865154.1 product_name: class A extended-spectrum beta-lactamase VEB-14 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-14 pubmed_reference: -> 26926646,31992391 blaVEB-15 WP_063865155.1 product_name: class A extended-spectrum beta-lactamase VEB-15 -> extended-spectrum class A beta-lactamase VEB-15 blaVEB-16 WP_063865156.1 product_name: class A extended-spectrum beta-lactamase VEB-16 -> extended-spectrum class A beta-lactamase VEB-16 blaVEB-17 WP_063865157.1 product_name: class A extended-spectrum beta-lactamase VEB-17 -> extended-spectrum class A beta-lactamase VEB-17 blaVEB-18 WP_065825678.1 product_name: class A extended-spectrum beta-lactamase VEB-18 -> extended-spectrum class A beta-lactamase VEB-18 blaVEB-19 WP_094009812.1 product_name: class A extended-spectrum beta-lactamase VEB-19 -> extended-spectrum class A beta-lactamase VEB-19 blaVEB-2 WP_063865158.1 product_name: class A extended-spectrum beta-lactamase VEB-2 -> extended-spectrum class A beta-lactamase VEB-2 blaVEB-20 WP_128268286.1 product_name: class A extended-spectrum beta-lactamase VEB-20 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-20 pubmed_reference: -> 31992391 blaVEB-21 WP_044103626.1 product_name: class A extended-spectrum beta-lactamase VEB-21 -> extended-spectrum class A beta-lactamase VEB-21 blaVEB-22 WP_148044475.1 product_name: class A extended-spectrum beta-lactamase VEB-22 -> extended-spectrum class A beta-lactamase VEB-22 blaVEB-23 WP_156404662.1 product_name: class A extended-spectrum beta-lactamase VEB-23 -> extended-spectrum class A beta-lactamase VEB-23 blaVEB-24 WP_156404663.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase VEB-24 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-24 blaVEB-25 WP_160164840.1 product_name: class A extended-spectrum beta-lactamase VEB-25 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-25 pubmed_reference: -> 31992391 blaVEB-26 WP_179284393.1 product_name: class A extended-spectrum beta-lactamase VEB-26 -> extended-spectrum class A beta-lactamase VEB-26 blaVEB-27 WP_188331880.1 product_name: inhibitor-resistant class A extended-spectrum beta-lactamase VEB-27 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-27 blaVEB-28 WP_231869593.1 product_name: class A extended-spectrum beta-lactamase VEB-28 -> extended-spectrum class A beta-lactamase VEB-28 blaVEB-29 WP_219860717.1 product_name: class A extended-spectrum beta-lactamase VEB-29 -> extended-spectrum class A beta-lactamase VEB-29 blaVEB-3 WP_020956917.1 product_name: class A extended-spectrum beta-lactamase VEB-3 -> extended-spectrum class A beta-lactamase VEB-3 blaVEB-30 WP_219860719.1 product_name: class A extended-spectrum beta-lactamase VEB-30 -> extended-spectrum class A beta-lactamase VEB-30 blaVEB-4 WP_063865159.1 product_name: class A extended-spectrum beta-lactamase VEB-4 -> extended-spectrum class A beta-lactamase VEB-4 blaVEB-5 WP_063865160.1 product_name: class A extended-spectrum beta-lactamase VEB-5 -> extended-spectrum class A beta-lactamase VEB-5 blaVEB-6 WP_063865161.1 product_name: class A extended-spectrum beta-lactamase VEB-6 -> extended-spectrum class A beta-lactamase VEB-6 blaVEB-7 WP_063865162.1 product_name: class A extended-spectrum beta-lactamase VEB-7 -> extended-spectrum class A beta-lactamase VEB-7 blaVEB-8 WP_063865163.1 product_name: class A extended-spectrum beta-lactamase VEB-8 -> extended-spectrum class A beta-lactamase VEB-8 blaVEB-9 WP_032494864.1 product_name: class A extended-spectrum beta-lactamase VEB-9 -> extended-spectrum class A beta-lactamase VEB-9 cepA-29 WP_063865204.1 product_name: class A extended-spectrum beta-lactamase CepA-29 -> extended-spectrum class A beta-lactamase CepA-29 cepA-44 WP_032579291.1 product_name: class A extended-spectrum beta-lactamase CepA-44 -> extended-spectrum class A beta-lactamase CepA-44 cepA-49 WP_008659027.1 product_name: class A extended-spectrum beta-lactamase CepA-49 -> extended-spectrum class A beta-lactamase CepA-49 poxtA2 WP_209691075.1 class: MACROLIDE -> PHENICOL/OXAZOLIDINONE subclass: MACROLIDE -> CHLORAMPHENICOL/FLORFENICOL/LINEZOLID Hierarchy nodes added core AMR AMR blaGMA blaGMA NF040812.1 GMA family class A beta-lactamase blaPJM blaPJM NF040874.1 PJM family subclass B3 metallo-beta-lactamase blaWUS blaWUS WUS family subclass B1 metallo-beta-lactamase erm(50) erm(50) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50) erm(51) erm(51) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(51) erm(52) erm(52) 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(52) fexB fexB NF040856.1 chloramphenicol/florfenicol efflux MFS transporter FexB Changed Hierarchy Nodes blaBEL BEL family extended-spectrum class A beta-lactamase name: BEL family class A extended-spectrum beta-lactamase -> BEL family extended-spectrum class A beta-lactamase blaCGA CGA family extended-spectrum class A beta-lactamase name: CGA family class A extended-spectrum beta-lactamase -> CGA family extended-spectrum class A beta-lactamase blaCIA CIA family extended-spectrum class A beta-lactamase name: CIA family class A extended-spectrum beta-lactamase -> CIA family extended-spectrum class A beta-lactamase blaCME CME family extended-spectrum class A beta-lactamase name: CME family class A extended-spectrum beta-lactamase -> CME family extended-spectrum class A beta-lactamase blaCTX-M CTX-M family extended-spectrum class A beta-lactamase name: CTX-M family class A extended-spectrum beta-lactamase -> CTX-M family extended-spectrum class A beta-lactamase blaKLUC KLUC family extended-spectrum class A beta-lactamase name: KLUC family class A extended-spectrum beta-lactamase -> KLUC family extended-spectrum class A beta-lactamase blaOCH OCH family extended-spectrum class C beta-lactamase name: OCH family class C extended-spectrum beta-lactamase -> OCH family extended-spectrum class C beta-lactamase blaOKP OKP family broad-spectrum class A beta-lactamase name: OKP family class A broad-spectrum beta-lactamase -> OKP family broad-spectrum class A beta-lactamase blaOKP-A OKP-A family broad-spectrum class A beta-lactamase name: OKP-A family class A broad-spectrum beta-lactamase -> OKP-A family broad-spectrum class A beta-lactamase blaOKP-B OKP-B family broad-spectrum class A beta-lactamase name: OKP-B family class A broad-spectrum beta-lactamase -> OKP-B family broad-spectrum class A beta-lactamase blaOKP-C OKP-C family broad-spectrum class A beta-lactamase name: OKP-C family class A broad-spectrum beta-lactamase -> OKP-C family broad-spectrum class A beta-lactamase blaOKP-D OKP-D family broad-spectrum class A beta-lactamase name: OKP-D family class A broad-spectrum beta-lactamase -> OKP-D family broad-spectrum class A beta-lactamase blaOXA-24_fam OXA-24 family carbapenem-hydrolyzing class D beta-lactamase subclass: BETA-LACTAM -> CARBAPENEM blaOXA-274_fam OXA-274 family carbapenem-hydrolyzing class D beta-lactamase name: OXA-274 family class D beta-lactamase -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase subclass: BETA-LACTAM -> CARBAPENEM blaOXA-286_fam OXA-286 family carbapenem-hydrolyzing class D beta-lactamase name: OXA-286 family class D beta-lactamase -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase subclass: BETA-LACTAM -> CARBAPENEM blaOXA-372_fam OXA-372 family carbapenem-hydrolyzing class D beta-lactamase subclass: BETA-LACTAM -> CARBAPENEM blaOXY OXY family extended-spectrum class A beta-lactamase name: OXY family class A extended-spectrum beta-lactamase -> OXY family extended-spectrum class A beta-lactamase blaOXY-1 OXY-1 family extended-spectrum class A beta-lactamase name: OXY-1 family class A extended-spectrum beta-lactamase -> OXY-1 family extended-spectrum class A beta-lactamase blaOXY-2 OXY-2 family extended-spectrum class A beta-lactamase name: OXY-2 family class A extended-spectrum beta-lactamase -> OXY-2 family extended-spectrum class A beta-lactamase blaOXY-3 OXY-3 family extended-spectrum class A beta-lactamase name: OXY-3 family class A extended-spectrum beta-lactamase -> OXY-3 family extended-spectrum class A beta-lactamase blaOXY-4 OXY-4 family extended-spectrum class A beta-lactamase name: OXY-4 family class A extended-spectrum beta-lactamase -> OXY-4 family extended-spectrum class A beta-lactamase blaOXY-5 OXY-5 family extended-spectrum class A beta-lactamase name: OXY-5 family class A extended-spectrum beta-lactamase -> OXY-5 family extended-spectrum class A beta-lactamase blaOXY-6 OXY-6 family extended-spectrum class A beta-lactamase name: OXY-6 family class A extended-spectrum beta-lactamase -> OXY-6 family extended-spectrum class A beta-lactamase blaPER PER family extended-spectrum class A beta-lactamase name: PER family class A extended-spectrum beta-lactamase -> PER family extended-spectrum class A beta-lactamase blaPME PME family extended-spectrum class A beta-lactamase name: PME family class A beta-lactamase -> PME family extended-spectrum class A beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN blaRASA RASA family extended-spectrum class A beta-lactamase name: RASA family class A extended-spectrum beta-lactamase -> RASA family extended-spectrum class A beta-lactamase blaRUB RUB family broad-spectrum class A beta-lactamase name: RUB family class A broad-spectrum beta-lactamase -> RUB family broad-spectrum class A beta-lactamase blaTLA TLA family extended-spectrum class A beta-lactamase name: TLA family class A extended-spectrum beta-lactamase -> TLA family extended-spectrum class A beta-lactamase blaTLA2 TLA2 family extended-spectrum class A beta-lactamase name: TLA2 family class A extended-spectrum beta-lactamase -> TLA2 family extended-spectrum class A beta-lactamase blaVEB VEB family extended-spectrum class A beta-lactamase name: VEB family class A extended-spectrum beta-lactamase -> VEB family extended-spectrum class A beta-lactamase cepA CepA family extended-spectrum class A beta-lactamase name: CepA family class A extended-spectrum beta-lactamase -> CepA family extended-spectrum class A beta-lactamase cfxA broad-spectrum class A beta-lactamase CfxA name: class A broad-spectrum beta-lactamase CfxA -> broad-spectrum class A beta-lactamase CfxA cfxA2 extended-spectrum class A beta-lactamase CfxA2 name: class A extended-spectrum beta-lactamase CfxA2 -> extended-spectrum class A beta-lactamase CfxA2 cfxA3 extended-spectrum class A beta-lactamase CfxA3 name: class A extended-spectrum beta-lactamase CfxA3 -> extended-spectrum class A beta-lactamase CfxA3 cfxA4 extended-spectrum class A beta-lactamase CfxA4 name: class A extended-spectrum beta-lactamase CfxA4 -> extended-spectrum class A beta-lactamase CfxA4 cfxA5 broad-spectrum class A beta-lactamase CfxA5 name: class A broad-spectrum beta-lactamase CfxA5 -> broad-spectrum class A beta-lactamase CfxA5 cfxA6 broad-spectrum class A beta-lactamase CfxA6 name: class A broad-spectrum beta-lactamase CfxA6 -> broad-spectrum class A beta-lactamase CfxA6 cfxA_fam CfxA family broad-spectrum class A beta-lactamase name: CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase entFM enterotoxin EntFM hmm_acc: -> NF040678.1 penI_Bp PenI family extended-spectrum class A beta-lactamase name: PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase poxtA ABC-F type ribosomal protection protein PoxtA class: MACROLIDE -> PHENICOL/OXAZOLIDINONE subclass: MACROLIDE -> CHLORAMPHENICOL/FLORFENICOL/LINEZOLID ---------------------------------------------------------------------- Changes included in 2022-04-04.1 ---------------------------------------------------------------------- Overview: - The usual addition of new alleles submitted to NCBI and genes/sequences identified by curators. - New point mutations for Klebsiella, Salmonella, Escherichia, and Enterococcus_faecium. - Added virulence genes for the Bacillus cereus group. - A few new beta-lactamase families (blaBOR, blaGMA, blaHBL). - The format of the ReferenceGeneCatalog.txt file has changed to add RefSeq coordinates and rename existing fields to make the column headers more consistent. This is in preparation for the development of a convenient system to download sequences from the Reference Gene Catalog (https://www.ncbi.nlm.nih.gov/pathogens/refgene. - Changed field names: - genbank_cds_start => genbank_start - genbank_cds_stop => genbank_stop - genbank_strand_orientation => genbank_strand - New fields - refseq_start - refseq_stop - refseq_strand - Where possible we added RefSeq / GenBank accessions and coordinates to point mutation records that were previously missing one or the other. Note that a new point mutation in Escherichia reveals bug in versions 3.10.23 and earlier. This bug means that with this new database AMRFinderPlus versions prior to 3.10.24 will no longer detect Escherichia pmrB_L10 mutations. See the release notes for more information: https://github.com/ncbi/amr/releases/tag/amrfinder_v3.10.24 The following list omits listing changes in the new/renamed columns: genbank_start, genbank_end, genbank_strand, refseq_start, refseq_end, and refseq_strand because those fields were added to every record in the Reference Gene Catalog. They may be empty if there is no accession, and they are not used by AMRFinderPlus. Summary: Total proteins: 7229 Core proteins: 6144 Plus proteins: 1084 AMR proteins: 6189 STRESS proteins: 235 VIRULENCE proteins: 805 Point mutations: 939 Point mutation references: 161 Point mutation organism groups: Acinetobacter_baumannii, Campylobacter, Clostridioides_difficile, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 665 Updates since release 2021-12-21.1: Proteins added: 194 Core proteins added: 130 Plus proteins added: 64 AMR proteins added: 130 VIRULENCE proteins added: 64 Alleles added: 129 Point mutations added: 21 Proteins removed: 1 Core proteins removed: 1 Plus proteins removed: 0 Reference Gene Catalog entries changed: 841 Hierarchy nodes added: 54 Hierarchy nodes changed: 5 Added proteins core AMR AMR fosY NG_079881.1 WP_072419811.1 fosfomycin resistance bacillithiol transferase FosY blaACT-100 NG_079207.1 WP_240067712.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-100 blaACT-101 NG_079208.1 WP_087529968.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-101 blaACT-102 NG_079209.1 WP_058690324.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-102 blaACT-103 NG_079210.1 WP_063943829.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-103 blaACT-104 NG_079211.1 WP_213782881.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-104 blaACT-105 NG_079882.1 WP_242934065.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-105 blaACT-106 NG_079883.1 WP_129256276.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-106 blaACT-107 NG_079884.1 WP_242934066.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-107 blaACT-95 NG_079212.1 WP_063434356.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-95 blaACT-96 NG_079213.1 WP_240067713.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-96 blaACT-97 NG_079214.1 WP_240067714.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-97 blaACT-98 NG_079215.1 WP_232932000.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-98 blaACT-99 NG_079216.1 WP_196347324.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-99 blaADC-257 NG_079217.1 WP_116020564.1 class C beta-lactamase ADC-257 blaADC-258 NG_079218.1 WP_114259520.1 class C beta-lactamase ADC-258 blaADC-261 NG_079219.1 WP_240067715.1 class C beta-lactamase ADC-261 blaADC-262 NG_079220.1 WP_213702342.1 class C beta-lactamase ADC-262 blaADC-263 NG_079221.1 WP_109433738.1 class C beta-lactamase ADC-263 blaADC-264 NG_079222.1 WP_240067716.1 class C beta-lactamase ADC-264 blaADC-265 NG_079885.1 WP_086265799.1 class C beta-lactamase ADC-265 blaAFM-4 NG_079223.1 WP_240067717.1 subclass B1 metallo-beta-lactamase AFM-4 blaBOR-1 NG_079224.1 WP_010926363.1 class A beta-lactamase BOR-1 blaCTX-M-252 NG_079225.1 WP_240067718.1 class A extended-spectrum beta-lactamase CTX-M-252 blaHBL-1 NG_079886.1 WP_080700357.1 class A beta-lactamase HBL-1 blaIMI-24 NG_079226.1 WP_240067719.1 carbapenem-hydrolyzing class A beta-lactamase IMI-24 blaIMP-92 NG_079227.1 WP_240067720.1 subclass B1 metallo-beta-lactamase IMP-92 blaIMP-93 NG_079228.1 WP_234855925.1 subclass B1 metallo-beta-lactamase IMP-93 blaIMP-94 NG_079229.1 WP_240067721.1 subclass B1 metallo-beta-lactamase IMP-94 blaIMP-95 NG_079887.1 WP_242934067.1 subclass B1 metallo-beta-lactamase IMP-95 blaKPC-112 NG_079230.1 WP_240067722.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-112 blaKPC-113 NG_079888.1 WP_242934068.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-113 blaKPC-114 NG_079889.1 WP_242934069.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-114 blaKPC-115 NG_079890.1 WP_242934070.1 inhibitor-resistant class A beta-lactamase KPC-115 blaKPC-116 NG_079891.1 WP_242934071.1 carbapenem-hydrolyzing class A beta-lactamase KPC-116 blaKPC-117 NG_079892.1 WP_242934072.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-117 blaKPC-118 NG_079893.1 WP_242934073.1 carbapenem-hydrolyzing class A beta-lactamase KPC-118 blaKPC-119 NG_079894.1 WP_242934074.1 carbapenem-hydrolyzing class A beta-lactamase KPC-119 blaKPC-120 NG_079895.1 WP_242934075.1 carbapenem-hydrolyzing class A beta-lactamase KPC-120 blaKPC-121 NG_079896.1 WP_242934076.1 carbapenem-hydrolyzing class A beta-lactamase KPC-121 blaKPC-122 NG_079897.1 WP_242934077.1 carbapenem-hydrolyzing class A beta-lactamase KPC-122 blaKPC-123 NG_079898.1 WP_242934078.1 inhibitor-resistant class A extended-spectrum beta-lactamase KPC-123 blaKPC-83 NG_079231.1 WP_240067723.1 carbapenem-hydrolyzing class A beta-lactamase KPC-83 blaKPC-89 NG_079232.1 WP_240067724.1 carbapenem-hydrolyzing class A beta-lactamase KPC-89 blaKPC-92 NG_079233.1 WP_240067725.1 inhibitor-resistant class A extended-spectrum beta-lactamase KPC-92 blaOXA-1044 NG_079234.1 WP_240067726.1 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-1044 blaOXA-1045 NG_079235.1 WP_046811527.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1045 blaOXA-1046 NG_079236.1 WP_240067727.1 OXA-10 family class D beta-lactamase OXA-1046 blaOXA-1047 NG_079237.1 WP_213384363.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1047 blaOXA-1048 NG_079238.1 WP_240067728.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1048 blaOXA-1049 NG_079239.1 WP_240067729.1 OXA-2 family class D beta-lactamase OXA-1049 blaOXA-1050 NG_079240.1 WP_240067730.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1050 blaOXA-1051 NG_079241.1 WP_240067731.1 class D beta-lactamase OXA-1051 blaOXA-1053 NG_079242.1 WP_240067732.1 OXA-10 family class D beta-lactamase OXA-1053 blaOXA-1055 NG_079243.1 WP_240067733.1 OXA-48 family class D beta-lactamase OXA-1055 blaOXA-1056 NG_079244.1 WP_240067734.1 OXA-198 family carbapenem-hydrolyzing class D beta-lactamase OXA-1056 blaOXA-1057 NG_079245.1 WP_240067735.1 OXA-198 family carbapenem-hydrolyzing class D beta-lactamase OXA-1057 blaOXA-1058 NG_079900.1 WP_242934079.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1058 blaOXA-1059 NG_079901.1 WP_242934080.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1059 blaOXA-1060 NG_079902.1 WP_242934081.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1060 blaOXA-1061 NG_079903.1 WP_242934082.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1061 blaOXA-1062 NG_079904.1 WP_242934083.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1062 blaOXA-1063 NG_079905.1 WP_242934084.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1063 blaOXA-1064 NG_079906.1 WP_242934085.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1064 blaOXA-1065 NG_079907.1 WP_242934086.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1065 blaOXA-1066 NG_079908.1 WP_242934087.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1066 blaOXA-1067 NG_079909.1 WP_242934088.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1067 blaOXA-1068 NG_079910.1 WP_242934089.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1068 blaOXA-1069 NG_079911.1 WP_242934090.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1069 blaOXA-1070 NG_079912.1 WP_242934091.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1070 blaOXA-1071 NG_079913.1 WP_242934092.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1071 blaOXA-1072 NG_079914.1 WP_242934093.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1072 blaOXA-1073 NG_079915.1 WP_242934094.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1073 blaOXA-1074 NG_079916.1 WP_242934095.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1074 blaOXA-1075 NG_079917.1 WP_242934096.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1075 blaOXA-1076 NG_079918.1 WP_215763651.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1076 blaOXA-1077 NG_079919.1 WP_242934097.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1077 blaOXA-1078 NG_079920.1 WP_242934098.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1078 blaOXA-1079 NG_079921.1 WP_242934099.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1079 blaOXA-1080 NG_079922.1 WP_242934100.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1080 blaOXA-1081 NG_079923.1 WP_242934101.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1081 blaOXA-1082 NG_079924.1 WP_242934102.1 OXA-2 family class D beta-lactamase OXA-1082 blaOXA-1083 NG_079925.1 WP_125064048.1 OXA-2 family class D beta-lactamase OXA-1083 blaOXA-1084 NG_079926.1 WP_242934103.1 OXA-2 family class D beta-lactamase OXA-1084 blaOXA-1085 NG_079927.1 WP_242934104.1 OXA-2 family class D beta-lactamase OXA-1085 blaOXA-1086 NG_079928.1 WP_242934105.1 OXA-10 family class D beta-lactamase OXA-1086 blaOXA-1089 NG_079246.1 WP_075071939.1 carbapenem-hydrolyzing class D beta-lactamase OXA-1089 blaOXA-1090 NG_079247.1 WP_051601260.1 carbapenem-hydrolyzing class D beta-lactamase OXA-1090 blaOXA-1091 NG_079248.1 WP_012045014.1 class D beta-lactamase OXA-1091 blaOXA-1092 NG_079929.1 WP_242934106.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1092 blaOXA-1093 NG_079930.1 WP_242934107.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1093 blaOXA-1094 NG_079931.1 WP_242934108.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1094 blaOXA-1095 NG_079932.1 WP_242934109.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1095 blaOXA-1096 NG_079933.1 WP_242934110.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1096 blaOXA-1097 NG_079934.1 WP_242934111.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1097 blaOXA-1098 NG_079935.1 WP_242934112.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1098 blaOXA-1099 NG_079936.1 WP_014936873.1 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1099 blaOXA-1100 NG_079937.1 WP_242934113.1 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1100 blaOXA-1101 NG_079938.1 WP_242934114.1 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1101 blaOXA-1102 NG_079939.1 WP_242934115.1 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1102 blaOXA-1103 NG_079940.1 WP_242934116.1 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1103 blaOXA-1104 NG_079941.1 WP_242934117.1 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1104 blaOXA-1105 NG_079942.1 WP_242934118.1 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1105 blaOXA-1106 NG_079943.1 WP_242934119.1 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1106 blaOXA-1107 NG_079944.1 WP_242934120.1 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1107 blaOXA-198 NG_049494.2 WP_094865115.1 carbapenem-hydrolyzing class D beta-lactamase OXA-198 blaOXA-289 NG_079946.1 WP_081400730.1 class D beta-lactamase OXA-289 blaOXA-290 NG_079947.1 WP_081398973.1 class D beta-lactamase OXA-290 blaPAM-2 NG_079249.1 WP_173179784.1 subclass B3 metallo-beta-lactamase PAM-2 blaPDC-501 NG_079250.1 WP_240067736.1 class C beta-lactamase PDC-501 blaPDC-502 NG_079251.1 WP_240067737.1 class C beta-lactamase PDC-502 blaPDC-503 NG_079252.1 WP_240067738.1 class C beta-lactamase PDC-503 blaPDC-504 NG_079253.1 WP_240067739.1 class C beta-lactamase PDC-504 blaPDC-505 NG_079254.1 WP_240067740.1 class C beta-lactamase PDC-505 blaPDC-506 NG_079255.1 WP_240067741.1 class C beta-lactamase PDC-506 blaPDC-507 NG_079256.1 WP_240067742.1 class C beta-lactamase PDC-507 blaPDC-508 NG_079257.1 WP_240067743.1 class C beta-lactamase PDC-508 blaPDC-509 NG_079258.1 WP_240067744.1 class C beta-lactamase PDC-509 blaPDC-510 NG_079259.1 WP_240067745.1 class C beta-lactamase PDC-510 blaPDC-511 NG_079260.1 WP_240067746.1 class C beta-lactamase PDC-511 blaPDC-512 NG_079948.1 WP_242934121.1 class C beta-lactamase PDC-512 blaPDC-514 NG_079949.1 WP_242934122.1 class C beta-lactamase PDC-514 blaPDC-515 NG_079950.1 WP_242934123.1 class C beta-lactamase PDC-515 blaPDC-516 NG_079951.1 WP_242934124.1 class C beta-lactamase PDC-516 blaTEM-245 NG_079952.1 WP_242934125.1 class A beta-lactamase TEM-245 blaTEM-246 NG_079953.1 WP_242934126.1 class A beta-lactamase TEM-246 blaVIM-80 NG_079261.1 WP_155684882.1 subclass B1 metallo-beta-lactamase VIM-80 mcr-1.33 NG_079262.1 WP_240067747.1 phosphoethanolamine--lipid A transferase MCR-1.33 mcr-1.34 NG_079263.1 WP_231236808.1 phosphoethanolamine--lipid A transferase MCR-1.34 mcr-10.5 NG_079954.1 WP_242934127.1 phosphoethanolamine--lipid A transferase MCR-10.5 plus VIRULENCE VIRULENCE pagA AF065404.1 AAD32414.1 anthrax toxin protective antigen atxA AF065404.1 AAD32423.1 anthrax toxin expression trans-acting transcriptional regulator AtxA plcR AF132087.1 AAD41788.1 transcriptional regulator PlcR capE AF188935.1 AAF13659.1 capsule biosynthesis protein CapE capB AF188935.1 AAF13663.1 capsule biosynthesis protein CapB sodC1 AE006468.2 AAL19978.1 superoxide dismutase [Cu-Zn] SodC1 lef AE011190.1 AAM26117.1 anthrax toxin lethal factor capD AE011191.1 AAM26219.1 capsule biosynthesis gamma-glutamyltransferase CapD capA AE011191.1 AAM26220.1 capsular polyglutamate synthetase CapA capC AE011191.1 AAM26221.1 capsular polyglutamate amide ligase/translocase CapC hlyIIR AY212780.1 AAO74585.1 hemolysin II regulator HlyIIR inhA2 AE016877.1 AAP07680.1 M6 family metalloprotease immune inhibitor InhA2 cytK2 AE016877.1 AAP08097.1 beta-channel forming cytolysin CytK2 nheC AE016877.1 AAP08785.1 non-hemolytic enterotoxin NHE subunit C entFM AE016877.1 AAP08924.1 enterotoxin EntFM hblB AE016877.1 AAP10046.1 hemolytic enterotoxin HBL binding subunit HblB hblD AE016877.1 AAP10047.1 hemolytic enterotoxin HBL lytic component L1 hblC AE016877.1 AAP10048.1 hemolytic enterotoxin HBL lytic component L2 hlyII AE016877.1 AAP10457.1 hemolysin II HlyII plcA AE016877.1 AAP10686.1 phosphatidylinositol diacylglycerol-lyase inhA2 AE016879.1 AAP24685.1 M6 family metalloprotease immune inhibitor InhA2 sph AE016879.1 AAP24691.1 sphingomyelinase C alo AE016879.1 AAP27127.1 anthrolysin O/cereolysin O family cholesterol-dependent cytolysin Alo plcA AE016879.1 AAP27624.1 phosphatidylinositol diacylglycerol-lyase cerA AE017194.1 AAS39677.1 phospholipase CerA nheA AE017194.1 AAS40892.1 non-hemolytic enterotoxin NHE subunit A nheB AE017194.1 AAS40893.1 non-hemolytic enterotoxin NHE subunit B nheC AE017194.1 AAS40894.1 non-hemolytic enterotoxin NHE subunit C plcR AE017355.1 AAT61178.1 transcriptional regulator PlcR alo AY818309.1 AAX88798.1 anthrolysin O/cereolysin O family cholesterol-dependent cytolysin Alo plcR DQ153391.1 AAZ81519.1 transcriptional regulator PlcR cesB DQ360825.1 ABD14712.1 cereulide non-ribosomal peptide synthetase CesB cesC DQ360825.1 ABD14713.1 cereulide export ABC transporter permease ATP-binding protein CesC cesD DQ360825.1 ABD14714.1 cereulide export ABC transporter permease subunit CesD cytK1 DQ885233.1 ABI52591.1 beta-channel forming cytolysin CytK1 entFM CP000764.1 ABS21809.1 enterotoxin EntFM inhA1 CP001903.1 ADH05944.1 M6 family metalloprotease immune inhibitor InhA1 plcA CP001907.1 AEA17368.1 phosphatidylinositol diacylglycerol-lyase entFM CP002091.1 AFH83235.1 enterotoxin EntFM cerB KC527544.1 AGL98063.1 sphingomyelinase CerB bpsH CP009940.1 AIY72950.1 oligosaccharide flippase family protein BpsH cya CP009330.1 AJG68144.1 anthrax toxin edema factor entFM CP009692.1 AJH19624.1 enterotoxin EntFM bpsX CP009591.1 AJI07938.1 LytR family transcriptional regulator BpsX bpsA CP009591.1 AJI07978.1 chain length determinant family protein BpsA bpsC CP009591.1 AJI07989.1 UTP--glucose-1-phosphate uridylyltransferase BpsC bpsF CP009591.1 AJI08022.1 UDP-N-acetylglucosamine 2-epimerase BpsF bpsE CP009591.1 AJI08079.1 N-acetylneuraminate synthase family protein BpsE bpsG CP009591.1 AJI08113.1 acylneuraminate cytidylyltransferase family protein BpsG hblA AJ007794.1 CAB64770.1 hemolytic enterotoxin HBL binding subunit HblA sph AJ629412.1 CAF33353.1 sphingomyelinase C entFM ACMA01000037.1 EEK89940.1 enterotoxin EntFM entFM ACML01000111.1 EEL50994.1 enterotoxin EntFM entFM ACMV01000124.1 EEM05837.1 enterotoxin EntFM entFM AHEA01000026.1 EJQ77255.1 enterotoxin EntFM entFM AHDB01000025.1 EJS75599.1 enterotoxin EntFM hasA JTAG01000003.1 KHA45933.1 hyaluronan synthase HasA cesA LRAA01000202.1 KXI80363.1 cereulide non-ribosomal peptide synthetase CesA entFM JAIKLI010000168.1 MBY0597968.1 enterotoxin EntFM tccP MPGY01000110.1 OJF41834.1 Tir-cytoskeleton coupling protein TccP plcA NVMJ01000055.1 PDZ54940.1 phosphatidylinositol diacylglycerol-lyase alo CP053938.1 QKI25716.1 anthrolysin O/cereolysin O family cholesterol-dependent cytolysin Alo bpsD CP065744.1 QPS53461.1 sugar transferase BpsD bpsB CP065744.1 QPS53570.1 tyrosine-protein kinase BpsB Added point mutations core AMR POINT basR_A80V COLISTIN Escherichia lapB_V43G COLISTIN Klebsiella lpxM_V30G COLISTIN Klebsiella mgrB_C39STOP COLISTIN Klebsiella mgrB_L17R COLISTIN Klebsiella mgrB_Q30STOP COLISTIN Klebsiella mgrB_V32G COLISTIN Klebsiella pbp5_M485A BETA-LACTAM Enterococcus_faecium pbp5_M485T BETA-LACTAM Enterococcus_faecium phoQ_A20S COLISTIN Klebsiella phoQ_D266DD COLISTIN Klebsiella phoQ_S56R COLISTIN Klebsiella pmrB_ALNQLV129del COLISTIN Klebsiella pmrB_E123D COLISTIN Escherichia pmrB_L14Q COLISTIN Escherichia pmrB_P94A COLISTIN Escherichia pmrB_R89P COLISTIN Salmonella pmrB_RPISLR6del COLISTIN Escherichia pmrB_RQRL11del COLISTIN Salmonella pmrB_T92P COLISTIN Escherichia pmrB_Y358N COLISTIN Escherichia Removed proteins core AMR AMR blaOXA-198 NG_049494.1 WP_063861498.1 class D beta-lactamase OXA-198 Changed reference gene catalog records 50S_L22_A103C WP_002851214.1 genbank_nucleotide_accession: -> AL111168.1 refseq_nucleotide_accession: -> NC_002163.1 50S_L22_A103V WP_002779996.1 genbank_nucleotide_accession: -> CP011015.1 refseq_nucleotide_accession: -> NZ_CP011015.1 50S_L22_A103V WP_002851214.1 genbank_nucleotide_accession: -> AL111168.1 refseq_nucleotide_accession: -> NC_002163.1 50S_L22_A84D WP_002779996.1 genbank_nucleotide_accession: -> CP011015.1 refseq_nucleotide_accession: -> NZ_CP011015.1 50S_L22_A84D WP_002851214.1 genbank_nucleotide_accession: -> AL111168.1 refseq_nucleotide_accession: -> NC_002163.1 50S_L22_A88E WP_002779996.1 genbank_nucleotide_accession: -> CP011015.1 refseq_nucleotide_accession: -> NZ_CP011015.1 50S_L22_A88E WP_002851214.1 genbank_nucleotide_accession: -> AL111168.1 refseq_nucleotide_accession: -> NC_002163.1 50S_L22_G86E WP_002779996.1 genbank_nucleotide_accession: -> CP011015.1 refseq_nucleotide_accession: -> NZ_CP011015.1 50S_L22_G86E WP_002851214.1 genbank_nucleotide_accession: -> AL111168.1 refseq_nucleotide_accession: -> NC_002163.1 50S_L22_G86V WP_002779996.1 genbank_nucleotide_accession: -> CP011015.1 refseq_nucleotide_accession: -> NZ_CP011015.1 50S_L22_G86V WP_002851214.1 genbank_nucleotide_accession: -> AL111168.1 refseq_nucleotide_accession: -> NC_002163.1 acrB_R620C WP_086259262.1 genbank_nucleotide_accession: -> NENT01000005.1 refseq_nucleotide_accession: -> NZ_NENT01000005.1 acrB_R717L WP_001132507.1 genbank_nucleotide_accession: -> CP012091.1 refseq_nucleotide_accession: -> NZ_CP012091.1 acrB_R717Q WP_001132507.1 genbank_nucleotide_accession: -> CP012091.1 refseq_nucleotide_accession: -> NZ_CP012091.1 acrR_M109I WP_002892080.1 genbank_nucleotide_accession: -> CP000647.1 refseq_nucleotide_accession: -> NC_009648.1 acrR_R45C WP_000101737.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 acrR_V165I WP_002892080.1 genbank_nucleotide_accession: -> CP000647.1 refseq_nucleotide_accession: -> NC_009648.1 acrR_Y114F WP_002892080.1 genbank_nucleotide_accession: -> CP000647.1 refseq_nucleotide_accession: -> NC_009648.1 adeR_A91V WP_031379794.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeR_D20N WP_031379794.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeR_E219A WP_031379794.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeR_L192R WP_031379794.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeR_P116L WP_031379794.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeR_P56S WP_031379794.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeS_G336S WP_031379793.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeS_H189Y WP_031379793.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeS_I252S WP_031379793.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeS_N125K WP_031379793.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeS_Q163STOP WP_031379793.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeS_R152K WP_031379793.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 adeS_T153M WP_031379793.1 genbank_nucleotide_accession: -> JNOT01000030.1 refseq_nucleotide_accession: -> NZ_JNOT01000030.1 ampD_H77Y WP_003112844.1 genbank_nucleotide_accession: -> AE004091.2 refseq_nucleotide_accession: -> NC_002516.2 ampD_T139M WP_003112844.1 genbank_nucleotide_accession: -> AE004091.2 refseq_nucleotide_accession: -> NC_002516.2 ampR_D135G WP_003137572.1 genbank_nucleotide_accession: -> CP000438.1 refseq_nucleotide_accession: -> NC_008463.1 ampR_G154R WP_003137572.1 genbank_nucleotide_accession: -> CP000438.1 refseq_nucleotide_accession: -> NC_008463.1 arnC_C161Y WP_014906821.1 genbank_nucleotide_accession: -> LFAY01000067.1 basR_G15R WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_G53A WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_G53C WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_G53E WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_G53R WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_G53S WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_G53V WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_G53W WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_L105P WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_R81L WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_R81S WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 pubmed_reference: -> 30863849 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 basR_S39I WP_094970923.1 genbank_nucleotide_accession: -> NQIR01000016.1 pubmed_reference: -> 30863849 refseq_nucleotide_accession: -> NZ_NQIR01000016.1 blaKPC-46 WP_148044421.1 pubmed_reference: -> 35107303 blaKPC-66 WP_188331871.1 pubmed_reference: 34339281 -> 34339281, 35107303 blaKPC-71 WP_194293134.1 product_name: inhibitor-resistant class A beta-lactamase KPC-71 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-71 pubmed_reference: -> 34935448, 35080422 subclass: CARBAPENEM -> CEPHALOSPORIN blaNDM-37 WP_214251060.1 genbank_nucleotide_accession: JAHAWM010000071.1 -> CP091926.1 genbank_protein_accession: MBT0809506.1 -> ULB43298.1 blaOXA-1005 WP_163170629.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1016 WP_219860728.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-1036 WP_104442312.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-646 WP_039902635.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-647 WP_140423315.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-648 WP_140423316.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-830 WP_152315468.1 product_name: class D beta-lactamase OXA-830 -> class D extended-spectrum beta-lactamase OXA-830 pubmed_reference: -> 31849884 blaOXA-900 WP_178317675.1 product_name: class D beta-lactamase OXA-900 -> carbapenem-hydrolyzing class D beta-lactamase OXA-900 pubmed_reference: -> 34576793 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-915 WP_168370988.1 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-991 WP_231869616.1 subclass: BETA-LACTAM -> CARBAPENEM blaSFDC-1 WP_218519361.1 pubmed_reference: -> 34227210 cdsA_D222N WP_000159119.1 genbank_nucleotide_accession: -> CP019562.1 refseq_nucleotide_accession: -> NZ_CP019562.1 cls_A20D WP_002289473.1 genbank_nucleotide_accession: -> CP013009.1 refseq_nucleotide_accession: -> NZ_CP013009.1 cls_A23V WP_000571549.1 genbank_nucleotide_accession: -> CP000253.1 refseq_nucleotide_accession: -> NC_007795.1 cls_D27N WP_002289473.1 genbank_nucleotide_accession: -> CP013009.1 refseq_nucleotide_accession: -> NZ_CP013009.1 cls_F60S WP_000571549.1 genbank_nucleotide_accession: -> CP000253.1 refseq_nucleotide_accession: -> NC_007795.1 cls_G178T WP_002289473.1 genbank_nucleotide_accession: -> CP013009.1 refseq_nucleotide_accession: -> NZ_CP013009.1 cls_H215R WP_002289473.1 genbank_nucleotide_accession: -> CP013009.1 refseq_nucleotide_accession: -> NZ_CP013009.1 cls_H215R WP_002413481.1 genbank_nucleotide_accession: -> CP002621.1 refseq_nucleotide_accession: -> NC_017316.1 cls_K59T WP_002289473.1 genbank_nucleotide_accession: -> CP013009.1 refseq_nucleotide_accession: -> NZ_CP013009.1 cls_L52F WP_000571549.1 genbank_nucleotide_accession: -> CP000253.1 refseq_nucleotide_accession: -> NC_007795.1 cls_N13I WP_002289473.1 genbank_nucleotide_accession: -> CP013009.1 refseq_nucleotide_accession: -> NZ_CP013009.1 cls_N13T WP_002289473.1 genbank_nucleotide_accession: -> CP013009.1 refseq_nucleotide_accession: -> NZ_CP013009.1 cls_NFQ77del WP_002413481.1 genbank_nucleotide_accession: -> CP002621.1 refseq_nucleotide_accession: -> NC_017316.1 cls_R218Q WP_002289473.1 genbank_nucleotide_accession: -> CP013009.1 refseq_nucleotide_accession: -> NZ_CP013009.1 cls_R218Q WP_002413481.1 genbank_nucleotide_accession: -> CP002621.1 refseq_nucleotide_accession: -> NC_017316.1 cls_R267H WP_002289473.1 genbank_nucleotide_accession: -> CP013009.1 refseq_nucleotide_accession: -> NZ_CP013009.1 cls_R267H WP_002413481.1 genbank_nucleotide_accession: -> CP002621.1 refseq_nucleotide_accession: -> NC_017316.1 cls_T33N WP_000571549.1 genbank_nucleotide_accession: -> CP000253.1 refseq_nucleotide_accession: -> NC_007795.1 cmeR_G86A WP_002843095.1 genbank_nucleotide_accession: -> AABKSW010000043.1 crrB_F84S WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 28874377 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_G183V WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 28874377 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_L94M WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 25385117 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_N141I WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 27067316 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_N141Y WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 28874377 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_P151L WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 28874377 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_P151S WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 27067316 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_Q10L WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 25385117 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_S195N WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 27067316 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_W140R WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 27067316 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 crrB_Y31H WP_004184324.1 genbank_nucleotide_accession: -> PYBH01000009.1 pubmed_reference: -> 27067316 refseq_nucleotide_accession: -> NZ_PYBH01000009.1 cyaA_S352T WP_000281668.1 genbank_nucleotide_accession: -> HG738867.1 refseq_nucleotide_accession: -> NZ_HG738867.1 dacB_G437D WP_003091272.1 genbank_nucleotide_accession: -> AE004091.2 refseq_nucleotide_accession: -> NC_002516.2 dacB_T428P WP_003091272.1 genbank_nucleotide_accession: -> AE004091.2 refseq_nucleotide_accession: -> NC_002516.2 dacB_W459STOP WP_003091272.1 genbank_nucleotide_accession: -> AE004091.2 refseq_nucleotide_accession: -> NC_002516.2 dfrB_F99I WP_000175752.1 genbank_nucleotide_accession: -> CP013132.1 refseq_nucleotide_accession: -> NZ_CP013132.1 dfrB_F99S WP_000175752.1 genbank_nucleotide_accession: -> CP013132.1 refseq_nucleotide_accession: -> NZ_CP013132.1 dfrB_F99Y WP_000175752.1 genbank_nucleotide_accession: -> CP013132.1 refseq_nucleotide_accession: -> NZ_CP013132.1 dfrB_H150R WP_000175752.1 genbank_nucleotide_accession: -> CP013132.1 refseq_nucleotide_accession: -> NZ_CP013132.1 dfrB_H31N WP_000175752.1 genbank_nucleotide_accession: -> CP013132.1 refseq_nucleotide_accession: -> NZ_CP013132.1 dfrB_L21V WP_000175752.1 genbank_nucleotide_accession: -> CP013132.1 refseq_nucleotide_accession: -> NZ_CP013132.1 dfrB_L41F WP_000175752.1 genbank_nucleotide_accession: -> CP013132.1 refseq_nucleotide_accession: -> NZ_CP013132.1 dfrB_N60I WP_000175752.1 genbank_nucleotide_accession: -> CP013132.1 refseq_nucleotide_accession: -> NZ_CP013132.1 eatA_T450I WP_002296175.1 genbank_nucleotide_accession: -> CP003351.1 refseq_nucleotide_accession: -> NC_017022.1 emrR_L113P WP_000378442.1 genbank_nucleotide_accession: -> AWBL01000027.1 emrR_L64R WP_000378442.1 genbank_nucleotide_accession: -> AWBL01000027.1 fabG_Y151V WP_001718014.1 genbank_nucleotide_accession: -> AQDR01000067.1 refseq_nucleotide_accession: -> NZ_AQDR01000067.1 fabI_F203A WP_000506490.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 fabI_F203C WP_000506490.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 fabI_F203L WP_000506490.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 fabI_F203V WP_000506490.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 fabI_G93A WP_000506490.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 fabI_G93S WP_000506490.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 fabI_G93V WP_000506490.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 fabI_M159T WP_000506490.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 folP_F25I WP_011017740.1 genbank_nucleotide_accession: -> AE009949.1 refseq_nucleotide_accession: -> NC_003485.1 folP_F28I WP_000764731.1 genbank_nucleotide_accession: -> BGJU01000040.1 refseq_nucleotide_accession: -> NZ_BGJU01000040.1 folP_F28L WP_000764731.1 genbank_nucleotide_accession: -> BGJU01000040.1 refseq_nucleotide_accession: -> NZ_BGJU01000040.1 folP_P64A WP_000764731.1 genbank_nucleotide_accession: -> BGJU01000040.1 refseq_nucleotide_accession: -> NZ_BGJU01000040.1 folP_P64H WP_000764731.1 genbank_nucleotide_accession: -> BGJU01000040.1 refseq_nucleotide_accession: -> NZ_BGJU01000040.1 folP_P64L WP_000764731.1 genbank_nucleotide_accession: -> BGJU01000040.1 refseq_nucleotide_accession: -> NZ_BGJU01000040.1 folP_P64R WP_000764731.1 genbank_nucleotide_accession: -> BGJU01000040.1 refseq_nucleotide_accession: -> NZ_BGJU01000040.1 folP_P64S WP_000764731.1 genbank_nucleotide_accession: -> BGJU01000040.1 refseq_nucleotide_accession: -> NZ_BGJU01000040.1 folP_R228S WP_003702942.1 genbank_nucleotide_accession: -> DS999940.1 refseq_nucleotide_accession: -> NZ_DS999940.1 ftsI_A515V WP_000227936.1 genbank_nucleotide_accession: -> JF745999.1 ftsI_I336IKYRI WP_000642196.1 genbank_nucleotide_accession: -> K00137.1 ftsI_I336IPYRI WP_000642196.1 genbank_nucleotide_accession: -> K00137.1 ftsI_N337NYRIN WP_000642196.1 genbank_nucleotide_accession: -> K00137.1 fusA_A160V WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_A376V WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_A655E WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_A655P WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_A655V WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_C473S WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_D189G WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_D189V WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_D373N WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_D387I WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_D434N WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_D463G WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_E233Q WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_E444K WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_E444V WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_F652S WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_F88L WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_G451V WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_G452C WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_G452S WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_G452V WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_G556S WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_G617D WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_G664S WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_H438N WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_H457L WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_H457N WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_H457Q WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_H457Y WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_I449K WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_L430S WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_L456F WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_L456K WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_L461F WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_L461K WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_L461S WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_M453I WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_M651I WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_P114H WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_P404L WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_P404Q WP_000090315.1 genbank_nucleotide_accession: -> BA000017.4 refseq_nucleotide_accession: -> NC_002758.2 fusA_P406L WP_000090315.1 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WP_000918664.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 rpoB_R505K WP_003436174.1 genbank_nucleotide_accession: -> AM180355.1 refseq_nucleotide_accession: -> NC_009089.1 rpoB_R529C WP_000263098.1 genbank_nucleotide_accession: -> CXAL01000043.1 refseq_nucleotide_accession: -> NZ_CXAL01000043.1 rpoB_R529S WP_000263098.1 genbank_nucleotide_accession: -> CXAL01000043.1 refseq_nucleotide_accession: -> NZ_CXAL01000043.1 rpoB_R687H WP_000263098.1 genbank_nucleotide_accession: -> CXAL01000043.1 refseq_nucleotide_accession: -> NZ_CXAL01000043.1 rpoB_S463N WP_000918664.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 rpoB_S463P WP_000918664.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 rpoB_S464P WP_000918664.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 rpoB_S486L WP_000918664.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 rpoB_S486L WP_014614750.1 genbank_nucleotide_accession: -> PPRB01000139.1 refseq_nucleotide_accession: -> NZ_PPRB01000139.1 rpoB_S488P WP_003436174.1 genbank_nucleotide_accession: -> AM180355.1 refseq_nucleotide_accession: -> NC_009089.1 rpoB_S529L WP_000918664.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 rpoB_S531F WP_000263098.1 genbank_nucleotide_accession: -> CXAL01000043.1 refseq_nucleotide_accession: -> NZ_CXAL01000043.1 rpoB_S550F WP_003436174.1 genbank_nucleotide_accession: -> AM180355.1 refseq_nucleotide_accession: -> NC_009089.1 rpoB_S550Y WP_003436174.1 genbank_nucleotide_accession: -> AM180355.1 refseq_nucleotide_accession: -> NC_009089.1 rpoB_T563P WP_000263098.1 genbank_nucleotide_accession: -> CXAL01000043.1 refseq_nucleotide_accession: -> NZ_CXAL01000043.1 rpoB_V146F WP_000263098.1 genbank_nucleotide_accession: -> CXAL01000043.1 refseq_nucleotide_accession: -> NZ_CXAL01000043.1 rpoC_D245Y WP_003429485.1 genbank_nucleotide_accession: -> AM180355.1 refseq_nucleotide_accession: -> NC_009089.1 rpoC_F632S WP_000567963.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 rpoC_Q961K WP_000567963.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 rpoD_DDDA92del WP_003688264.1 genbank_nucleotide_accession: -> CP001050.1 refseq_nucleotide_accession: -> NC_011035.1 rpoD_E98K WP_003688264.1 genbank_nucleotide_accession: -> CP001050.1 refseq_nucleotide_accession: -> NC_011035.1 rpsE_K28E WP_002215445.1 genbank_nucleotide_accession: -> AE002098.2 refseq_nucleotide_accession: -> NC_003112.2 rpsE_T24P WP_002215445.1 genbank_nucleotide_accession: -> AE002098.2 refseq_nucleotide_accession: -> NC_003112.2 rpsE_V27del WP_002215445.1 genbank_nucleotide_accession: -> AE002098.2 refseq_nucleotide_accession: -> NC_003112.2 rpsJ_V57L WP_001181005.1 genbank_nucleotide_accession: -> KC843636.1 rpsJ_V57L WP_002215394.1 genbank_nucleotide_accession: -> AE002098.2 refseq_nucleotide_accession: -> NC_003112.2 rpsJ_V57M WP_002215394.1 genbank_nucleotide_accession: -> AE002098.2 refseq_nucleotide_accession: -> NC_003112.2 rpsJ_V57Q WP_002215394.1 genbank_nucleotide_accession: -> AE002098.2 refseq_nucleotide_accession: -> NC_003112.2 rpsL_K43R WP_057042458.1 genbank_nucleotide_accession: -> AABMHE010000010.1 rpsL_K88E WP_057042458.1 genbank_nucleotide_accession: -> AABMHE010000010.1 rpsL_K88Q WP_057042458.1 genbank_nucleotide_accession: -> AABMHE010000010.1 rpsL_K88R WP_057042458.1 genbank_nucleotide_accession: -> AABMHE010000010.1 soxR_G121D WP_000412428.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 soxR_G121D WP_000412686.1 genbank_nucleotide_accession: -> AL513382.1 refseq_nucleotide_accession: -> NC_003198.1 soxR_R20H WP_000412428.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 soxR_R20H WP_000412686.1 genbank_nucleotide_accession: -> AL513382.1 refseq_nucleotide_accession: -> NC_003198.1 soxS_A12S WP_000019358.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 soxS_E52K WP_000019483.1 genbank_nucleotide_accession: -> AE006468.2 refseq_nucleotide_accession: -> NC_003197.2 tufA_A376S WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_A376T WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_A376V WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_E379K WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_G317D WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_L121Q WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_Q125E WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_Q125K WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_Q125R WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_Q330H WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_R231C WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_R231V WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_R234F WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_R234S WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_R334C WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_T335A WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_Y161C WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_Y161D WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 tufA_Y161N WP_000031783.1 genbank_nucleotide_accession: -> U00096.3 refseq_nucleotide_accession: -> NC_000913.3 uhpA_G97D WP_000633668.1 genbank_nucleotide_accession: -> HG738867.1 refseq_nucleotide_accession: -> NZ_HG738867.1 uhpT_E350Q WP_000879194.1 genbank_nucleotide_accession: -> HG738867.1 refseq_nucleotide_accession: -> NZ_HG738867.1 uhpT_G112E WP_001008722.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 uhpT_G358V WP_001008722.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 uhpT_W228STOP WP_001008722.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 uhpT_W425R WP_001008722.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 uhpT_Y314STOP WP_001008722.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 walK_L10F WP_000871610.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 walK_R263C WP_000871610.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 walK_S221P WP_000871610.1 genbank_nucleotide_accession: -> BX571856.1 refseq_nucleotide_accession: -> NC_002952.2 yybT_I440S WP_002356022.1 genbank_nucleotide_accession: -> AE016830.1 refseq_nucleotide_accession: -> NC_004668.1 Hierarchy nodes added core AMR AMR blaBOR blaBOR NF040659.1 BOR family class A beta-lactamase blaGMA blaGMA NF040812.1 GMA family class A beta-lactamase blaHBL blaHBL HBL family class A beta-lactamase blaOXA-1089_fam blaOXA NF040804.1 OXA-1089 family carbapenem-hydrolyzing class D beta-lactamase blaOXA-1091_fam blaOXA NF040803.1 OXA-1091 family class D beta-lactamase blaOXA-198_fam blaOXA NF040806.1 OXA-198 family carbapenem-hydrolyzing class D beta-lactamase blaOXA-732_fam blaOXA NF040805.1 OXA-732 family class D beta-lactamase blaOXA-VL06 blaOXA NF040784.1 OXA-1090 family carbapenem-hydrolyzing class D beta-lactamase fosY fosY NF040802.1 fosfomycin resistance bacillithiol transferase FosY non-reported VIRULENCE VIRULENCE VIRULENCE_Bcer plus VIRULENCE VIRULENCE alo alo anthrolysin O/cereolysin O family cholesterol-dependent cytolysin Alo atxA atxA anthrax toxin expression trans-acting transcriptional regulator AtxA bpsA bpsA chain length determinant family protein BpsA bpsB bpsB tyrosine-protein kinase BpsB bpsC bpsC UTP--glucose-1-phosphate uridylyltransferase BpsC bpsD bpsD sugar transferase BpsD bpsE bpsE N-acetylneuraminate synthase family protein BpsE bpsF bpsF UDP-N-acetylglucosamine 2-epimerase BpsF bpsG bpsG acylneuraminate cytidylyltransferase family protein BpsG bpsH bpsH oligosaccharide flippase family protein BpsH bpsX bpsX LytR family transcriptional regulator BpsX capA capA capsular polyglutamate synthetase CapA capB capB capsule biosynthesis protein CapB capC capC capsular polyglutamate amide ligase/translocase CapC capD capD capsule biosynthesis gamma-glutamyltransferase CapD capE capE capsule biosynthesis protein CapE cerA cerA phospholipase CerA cerB cerB sphingomyelinase CerB cesA cesA cereulide non-ribosomal peptide synthetase CesA cesB cesB cereulide non-ribosomal peptide synthetase CesB cesC cesC cereulide export ABC transporter permease ATP-binding protein CesC cesD cesD cereulide export ABC transporter permease subunit CesD cya cya anthrax toxin edema factor cytK1 cytK1 beta-channel forming cytolysin CytK1 cytK2 cytK2 beta-channel forming cytolysin CytK2 entFM entFM enterotoxin EntFM hasA hasA hyaluronan synthase HasA hblA hblA hemolytic enterotoxin HBL binding subunit HblA hblB hblB hemolytic enterotoxin HBL binding subunit HblB hblC hblC hemolytic enterotoxin HBL lytic component L2 hblD hblD hemolytic enterotoxin HBL lytic component L1 hlyII hlyII hemolysin II HlyII hlyIIR hlyIIR hemolysin II regulator HlyIIR inhA1 inhA1 M6 family metalloprotease immune inhibitor InhA1 inhA2 inhA2 M6 family metalloprotease immune inhibitor InhA2 lef lef anthrax toxin lethal factor nheA nheA non-hemolytic enterotoxin NHE subunit A nheB nheB non-hemolytic enterotoxin NHE subunit B nheC nheC non-hemolytic enterotoxin NHE subunit C pagA pagA anthrax toxin protective antigen plcA plcA phosphatidylinositol diacylglycerol-lyase plcR plcR transcriptional regulator PlcR sodC1 sodC1 superoxide dismutase [Cu-Zn] SodC1 sph sph sphingomyelinase C Changed Hierarchy Nodes blaOXA-372_fam OXA-372 family carbapenem-hydrolyzing class D beta-lactamase hmm_acc: NF000415.2 -> NF000415.3 blaPAM PAM family subclass B3 metallo-beta-lactamase hmm_acc: -> NF040644.1 blaPRC PRC family class C beta-lactamase hmm_acc: -> NF038359.1 blaSFDC SFDC family class C beta-lactamase hmm_acc: -> NF038366.1 espF type III secretion system LEE effector EspF hmm_acc: -> NF040807.1 ---------------------------------------------------------------------- Changes included in 2021-12-21.1 ---------------------------------------------------------------------- Overview: - eat(A) (AFC62715.1) was made a non-reportable reference because the reference protein does not confer resistance, but a known point mutation on that reference does. The resistance point mutation (eatA_T450I in Enterococcus faecium) is included in the database. - Some protein names were modified slightly to help regularize protein names across the database. - Several beta-lactamases had updates to their subclasses based on publications. - New sequences were chosen for several blaB alleles to correct start sites. Those show up as removed and added in the lists below because the accessions were changed. - New linezolid resistant 23S point mutations for Enterococcus_faecium and Enterococcus_faecalis were added. - Continued curation to add pubmed citations for some genes. - A new blaOXA-1043 node (and HMM) were created as part of our efforts to better organize blaOXA. - Three new families of beta-lactamase were added (blaPRC, blaRASA, and blaSHD). - Yersinia enterolytica virulence genes were added. - dfrC (CAA88269.1 and NF000155.1) was made non-reportable as a gene because the reference sequence is sensitive (PMID:7768789), however a variant is resistant. We added the variant as a resistant allele. - A few 'plus' nodes were added with HMMs only because protein sequences that meet our requirements are not available, but we felt the genes were sufficiently important to include. - The usual addition of new alleles submitted to NCBI for allele assignment. Summary: Total proteins: 7036 Core proteins: 6015 Plus proteins: 1020 AMR proteins: 6060 STRESS proteins: 235 VIRULENCE proteins: 741 Point mutations: 918 Point mutation references: 158 Point mutation organism groups: Acinetobacter_baumannii, Campylobacter, Clostridioides_difficile, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 654 Updates since release 2021-09-30.1: Proteins added: 128 Core proteins added: 100 Plus proteins added: 28 AMR proteins added: 101 STRESS proteins added: 2 VIRULENCE proteins added: 25 Alleles added: 100 Point mutations added: 4 Proteins removed: 6 Core proteins removed: 6 Plus proteins removed: 0 Reference Gene Catalog entries changed: 25 Hierarchy nodes added: 36 Hierarchy nodes removed: 0 Hierarchy nodes changed: 8 Added proteins core AMR AMR blaADC-259 NG_078048.1 WP_046882921.1 class C beta-lactamase ADC-259 blaADC-260 NG_078049.1 WP_231869648.1 class C beta-lactamase ADC-260 blaAIM-2 NG_078036.1 WP_231869638.1 subclass B3 metallo-beta-lactamase AIM-2 blaAXC-7 NG_078067.1 WP_231873785.1 carbapenem-hydrolyzing class A beta-lactamase AXC-7 blaB-10 NG_077980.1 WP_078782085.1 subclass B1 metallo-beta-lactamase BlaB-10 blaB-14 NG_048696.2 WP_078394827.1 subclass B1 metallo-beta-lactamase BlaB-14 blaB-7 NG_077981.1 WP_078402391.1 subclass B1 metallo-beta-lactamase BlaB-7 blaB-8 NG_077979.1 WP_078721108.1 subclass B1 metallo-beta-lactamase BlaB-8 blaB-9 NG_077978.1 WP_081321989.1 subclass B1 metallo-beta-lactamase BlaB-9 blaCARB-58 NG_077982.1 WP_231869590.1 PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-58 blaCME-3 NG_078057.1 WP_009085188.1 class A extended-spectrum beta-lactamase CME-3 blaCMH-7 NG_078039.1 WP_231869641.1 class C beta-lactamase CMH-7 blaCMY-177 NG_078046.1 WP_231869646.1 class C beta-lactamase CMY-177 blaCMY-179 NG_078068.1 WP_187259226.1 class C beta-lactamase CMY-179 blaCTX-M-251 NG_078045.1 WP_231869645.1 class A extended-spectrum beta-lactamase CTX-M-251 blaGES-50 NG_077975.1 WP_231869588.1 carbapenem-hydrolyzing class A beta-lactamase GES-50 blaGES-51 NG_077976.1 WP_200925854.1 carbapenem-hydrolyzing class A beta-lactamase GES-51 blaIMI-23 NG_077972.1 WP_223525081.1 carbapenem-hydrolyzing class A beta-lactamase IMI-23 blaKPC-102 NG_078063.1 WP_231873781.1 carbapenem-hydrolyzing class A beta-lactamase KPC-102 blaKPC-103 NG_078051.1 WP_231869650.1 class A beta-lactamase KPC-103 blaKPC-104 NG_078052.1 WP_231869651.1 class A beta-lactamase KPC-104 blaKPC-105 NG_078054.1 WP_231869653.1 class A beta-lactamase KPC-105 blaKPC-106 NG_078056.1 WP_231869655.1 class A beta-lactamase KPC-106 blaKPC-107 NG_078053.1 WP_231869652.1 class A beta-lactamase KPC-107 blaKPC-108 NG_078055.1 WP_231869654.1 class A beta-lactamase KPC-108 blaKPC-96 NG_078037.1 WP_231869639.1 carbapenem-hydrolyzing class A beta-lactamase KPC-96 blaKPC-97 NG_078038.1 WP_231869640.1 class A beta-lactamase KPC-97 blaKPC-98 NG_078032.1 WP_231869634.1 carbapenem-hydrolyzing class A beta-lactamase KPC-98 blaMOX-16 NG_077977.1 WP_231869589.1 CMY-1/MOX family class C beta-lactamase MOX-16 blaNDM-41 NG_078034.1 WP_231869636.1 subclass B1 metallo-beta-lactamase NDM-41 blaOXA-1000 NG_078021.1 WP_231869625.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1000 blaOXA-1001 NG_078022.1 WP_042088348.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1001 blaOXA-1002 NG_078023.1 WP_231869626.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1002 blaOXA-1003 NG_078024.1 WP_231869627.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1003 blaOXA-1004 NG_078025.1 WP_231869628.1 OXA-294 family class D beta-lactamase OXA-1004 blaOXA-1005 NG_078026.1 WP_163170629.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1005 blaOXA-1006 NG_078027.1 WP_231869629.1 class D beta-lactamase OXA-1006 blaOXA-1007 NG_078028.1 WP_231869630.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1007 blaOXA-1008 NG_078029.1 WP_231869631.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1008 blaOXA-1009 NG_078030.1 WP_231869632.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1009 blaOXA-1010 NG_078031.1 WP_231869633.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1010 blaOXA-1038 NG_078041.1 WP_231869643.1 OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-1038 blaOXA-1039 NG_078042.1 WP_037414505.1 OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-1039 blaOXA-1040 NG_078047.1 WP_231869647.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1040 blaOXA-1041 NG_078050.1 WP_231869649.1 OXA-427 family class D beta-lactamase OXA-1041 blaOXA-1042 NG_077974.1 WP_231869587.1 OXA-1 family class D beta-lactamase OXA-1042 blaOXA-1043 NG_077971.1 WP_077021671.1 class D beta-lactamase OXA-1043 blaOXA-933 NG_077983.1 WP_231869591.1 OXA-48 family class D beta-lactamase OXA-933 blaOXA-934 NG_077984.1 WP_231869592.1 OXA-48 family class D beta-lactamase OXA-934 blaOXA-966 NG_077987.1 WP_005405099.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-966 blaOXA-967 NG_077988.1 WP_231869594.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-967 blaOXA-968 NG_077989.1 WP_231869595.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-968 blaOXA-969 NG_077990.1 WP_231869596.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-969 blaOXA-970 NG_077991.1 WP_231869597.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-970 blaOXA-971 NG_077992.1 WP_231869598.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-971 blaOXA-972 NG_077993.1 WP_231869599.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-972 blaOXA-973 NG_077994.1 WP_231869600.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-973 blaOXA-974 NG_077995.1 WP_231869601.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-974 blaOXA-975 NG_077996.1 WP_231869602.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-975 blaOXA-976 NG_077997.1 WP_001022757.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-976 blaOXA-977 NG_077998.1 WP_231869603.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-977 blaOXA-978 NG_077999.1 WP_231869604.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-978 blaOXA-979 NG_078000.1 WP_231869605.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-979 blaOXA-980 NG_078001.1 WP_081174195.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-980 blaOXA-981 NG_078002.1 WP_231869606.1 class D beta-lactamase OXA-981 blaOXA-982 NG_078003.1 WP_231869607.1 OXA-294 family class D beta-lactamase OXA-982 blaOXA-983 NG_078004.1 WP_231869608.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-983 blaOXA-984 NG_078005.1 WP_231869609.1 OXA-294 family class D beta-lactamase OXA-984 blaOXA-985 NG_078006.1 WP_231869610.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-985 blaOXA-986 NG_078007.1 WP_231869611.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-986 blaOXA-987 NG_078008.1 WP_231869612.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-987 blaOXA-988 NG_078009.1 WP_231869613.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-988 blaOXA-989 NG_078010.1 WP_231869614.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-989 blaOXA-990 NG_078011.1 WP_231869615.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-990 blaOXA-991 NG_078012.1 WP_231869616.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-991 blaOXA-992 NG_078013.1 WP_231869617.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-992 blaOXA-993 NG_078014.1 WP_231869618.1 OXA-294 family class D beta-lactamase OXA-993 blaOXA-994 NG_078015.1 WP_231869619.1 OXA-294 family class D beta-lactamase OXA-994 blaOXA-995 NG_078016.1 WP_231869620.1 OXA-294 family class D beta-lactamase OXA-995 blaOXA-996 NG_078017.1 WP_231869621.1 OXA-294 family class D beta-lactamase OXA-996 blaOXA-997 NG_078018.1 WP_231869622.1 OXA-294 family class D beta-lactamase OXA-997 blaOXA-998 NG_078019.1 WP_231869623.1 OXA-294 family class D beta-lactamase OXA-998 blaOXA-999 NG_078020.1 WP_231869624.1 class D beta-lactamase OXA-999 blaPDC-497 NG_078033.1 WP_231869635.1 class C beta-lactamase PDC-497 blaPDC-498 NG_078064.1 WP_231873782.1 class C beta-lactamase PDC-498 blaPDC-499 NG_078065.1 WP_231873783.1 class C beta-lactamase PDC-499 blaPDC-500 NG_078066.1 WP_231873784.1 inhibitor-resistant class C beta-lactamase PDC-500 blaPRC-1 NG_077986.1 WP_230924646.1 class C beta-lactamase PRC-1 blaRASA-1 NG_077969.1 WP_064964747.1 class A extended-spectrum beta-lactamase RASA-1 blaSFC-3 NG_077966.1 WP_051363721.1 carbapenem-hydrolyzing class A beta-lactamase SFC-3 blaSHD-1 NG_077967.1 WP_011495276.1 subclass B1 metallo-beta-lactamase SHD-1 blaVEB-28 NG_077985.1 WP_231869593.1 class A extended-spectrum beta-lactamase VEB-28 blaVIM-77 NG_078035.1 WP_231869637.1 subclass B1 metallo-beta-lactamase VIM-77 blaVIM-78 NG_078043.1 WP_142836723.1 subclass B1 metallo-beta-lactamase VIM-78 blaVIM-79 NG_078044.1 WP_231869644.1 subclass B1 metallo-beta-lactamase VIM-79 dfrS1 NG_077973.1 WP_000175735.1 trimethoprim-resistant dihydrofolate reductase DfrS1 npmB1 NG_077965.1 WP_231869586.1 16S rRNA (adenine(1408)-N(1))-methyltransferase NpmB1 npmB2 NG_077964.1 WP_231869585.1 16S rRNA (adenine(1408)-N(1))-methyltransferase NpmB2 qnrA13 NG_078040.1 WP_231869642.1 quinolone resistance pentapeptide repeat protein QnrA13 qnrB97 NG_078069.1 WP_187259598.1 quinolone resistance pentapeptide repeat protein QnrB97 plus AMR AMR emrC AAAIJS010000026.1 EAC4468893.1 multidrug efflux transporter outer membrane subunit EmrC plus STRESS BIOCIDE emrE CP001602.2 ADB68610.1 quaternary ammonium compound efflux SMR transporter EmrE plus STRESS METAL arsN1 AE015451.2 AAN67541.1 arsinothricin resistance N-acetyltransferase ArsN1 family B plus VIRULENCE VIRULENCE ystA U09235.1 AAA18472.1 ST-I family heat-stable enterotoxin YstA ail M29945.1 AAA88694.1 attachment invasion locus protein Ail virF AF102990.1 AAD16833.1 virulence regulon transcriptional activator VirF hreP AF354753.1 AAK40114.1 subtilisin/kexin-like serine protease HreP yopD AF336309.1 AAK69210.1 type III secretion system translocon subunit YopD yopB AF336309.1 AAK69211.1 type III secretion system translocon subunit YopB yopJ AY150843.2 AAN37537.1 YopJ/YopP family T3SS effector serine/threonine acetyltransferase ymoA AY387659.1 AAQ90017.1 expression modulating protein YmoA tcbA AY647257.1 AAT90756.1 Tc family toxin subunit TcbA tcaC AY647257.1 AAT90757.1 Tc family toxin subunit TcaC tccC AY647257.1 AAT90761.1 Tc family toxin RHS repeat subunit TccC myfA JF838170.1 AEO31530.1 fimbrial protein MyfA yopM CP009845.1 AJJ21446.1 type III secretion system effector YopM yopH CP009845.1 AJJ21453.1 T3SS effector protein-tyrosine-phosphatase YopH yopT CP009845.1 AJJ21466.1 T3SS effector cysteine protease YopT yopE CP009845.1 AJJ21471.1 type III secretion system effector GTPase activator YopE yopJ KR088867.1 AKN09807.1 YopJ/YopP family T3SS effector serine/threonine acetyltransferase ystB D88145.1 BAA13544.1 ST-I family heat-stable enterotoxin YstB ystC D63578.1 BAA23656.1 ST-I family heat-stable enterotoxin YstC myfA Z21953.1 CAA79951.1 fimbrial protein MyfA inv HF933206.1 CCV30618.1 autotransporter invasin Inv yopO CGBC01000084.1 CFQ25321.1 type III secretion system effector protein kinase YopO/YpkA lcrV CPVJ01000032.1 CNC59088.1 type III secretion system needle tip protein LcrV yadA CHJR01000063.1 CNC65351.1 trimeric autotransporter adhesin YadA yadA CWIZ01000032.1 CRY27194.1 trimeric autotransporter adhesin YadA Added point mutations core AMR POINT 23S_G2505A LINEZOLID Enterococcus_faecium 23S_G2505A LINEZOLID Enterococcus_faecalis 23S_G2576T LINEZOLID Enterococcus_faecium 23S_G2576T LINEZOLID Enterococcus_faecalis Removed proteins core AMR AMR dfrC NG_047752.1 WP_001830952.1 trimethoprim-resistant dihydrofolate reductase DfrC blaB-10 NG_048692.1 WP_063857822.1 subclass B1 metallo-beta-lactamase BlaB-10 blaB-14 NG_048696.1 WP_034848068.1 subclass B1 metallo-beta-lactamase BlaB-14 blaB-7 NG_048701.1 WP_063857829.1 subclass B1 metallo-beta-lactamase BlaB-7 blaB-8 NG_048702.1 WP_059324801.1 subclass B1 metallo-beta-lactamase BlaB-8 blaB-9 NG_048703.1 WP_059154943.1 subclass B1 metallo-beta-lactamase BlaB-9 Changed reference gene catalog records blaCME-1 WP_059330348.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaCME-2 WP_063859570.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaCMY-172 WP_215824899.1 product_name: class C beta-lactamase CMY-172 -> inhibitor-resistant class C beta-lactamase CMY-172 pubmed_reference: -> 34044150 blaCTX-M-219 WP_110092882.1 pubmed_reference: -> 28637339 blaCTX-M-243 WP_213994580.1 pubmed_reference: -> 34865035 blaGES-49 WP_219860707.1 subclass: CEPHALOSPORIN -> CARBAPENEM blaKPC-14 WP_063860636.1 pubmed_reference: -> 31127297, 32848008 blaKPC-28 WP_072081992.1 pubmed_reference: -> 32848008 blaKPC-39 WP_128268237.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-39 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-39 pubmed_reference: -> 34606331 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-41 WP_148044419.1 pubmed_reference: -> 31527032 blaKPC-49 WP_197749402.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-49 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-49 pubmed_reference: -> 33466574 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-50 WP_171476788.1 pubmed_reference: -> 32457107 blaKPC-69 WP_210205486.1 product_name: class A beta-lactamase KPC-69 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-69 pubmed_reference: -> 34339281 subclass: CARBAPENEM -> CEPHALOSPORIN blaOXA-935 WP_141989064.1 genbank_cds_start: 10289 -> 65493 genbank_cds_stop: 11089 -> 66293 genbank_nucleotide_accession: VIHR01000047.1 -> CP083367.1 genbank_protein_accession: TQH06257.1 -> UBI73554.1 blaPDC-245 WP_100831609.1 pubmed_reference: -> 31636072 blaPDC-322 WP_138403314.1 pubmed_reference: -> 31636072 blaPDC-346 WP_148044438.1 pubmed_reference: -> 31636072 blaPDC-381 WP_148044467.1 pubmed_reference: -> 31636072 blaPDC-423 WP_134600670.1 product_name: class C beta-lactamase PDC-423 -> inhibitor-resistant class C beta-lactamase PDC-423 pubmed_reference: -> 31636072 blaPDC-468 WP_204376241.1 product_name: class C beta-lactamase PDC-468 -> inhibitor-resistant class C beta-lactamase PDC-468 pubmed_reference: -> 31636072 blaRSC1-1 WP_128268282.1 product_name: RSC1 family class C beta-lactamase -> class C beta-lactamase RSC1-1 blaRSD1-1 WP_128268283.1 product_name: RSD1 family class D beta-lactamase -> class D beta-lactamase RSD1-1 mcr-9.1 AYW01299.1 pubmed_reference: 31064835 -> 31064835, 32513803 mcr-9.2 MBO4175406.1 pubmed_reference: -> 32513803 mcr-9.3 QKF95689.1 pubmed_reference: -> 32513803 Hierarchy nodes added core AMR AMR blaOXA-1043_fam blaOXA NF040600.1 OXA-1043 family class D beta-lactamase blaPRC blaPRC PRC family class C beta-lactamase blaRASA blaRASA NF040609.1 RASA family class A extended-spectrum beta-lactamase blaSHD blaSHD SHD family subclass B1 metallo-beta-lactamase lnu(E) lnu(E) NF000478.2 lincosamide nucleotidyltransferase Lnu(E) npmB npmB NF040634.1 16S rRNA (adenine(1408)-N(1))-methyltransferase NpmB tet(43) tet(43) NF012180.1 tetracycline efflux MFS transporter Tet(43) non-reported VIRULENCE VIRULENCE VIRULENCE_Yersi plus AMR AMR emrC_Lis emrC multidrug efflux transporter outer membrane subunit EmrC plus STRESS BIOCIDE emrE_Lis emrE quaternary ammonium compound efflux SMR transporter EmrE plus STRESS METAL arsN1a arsN1 NF040503.1 arsinothricin resistance N-acetyltransferase ArsN1 family A arsN1b arsN1 NF040504.1 arsinothricin resistance N-acetyltransferase ArsN1 family B arsN2 arsN2 NF040501.1 arsenic resistance N-acetyltransferase ArsN2 arsN_gen arsN ArsN family N-acetyltransferase plus VIRULENCE VIRULENCE ail ail attachment invasion locus protein Ail hreP hreP subtilisin/kexin-like serine protease HreP inv inv autotransporter invasin Inv lcrV lcrV type III secretion system needle tip protein LcrV myfA myfA fimbrial protein MyfA tcaC tcaC Tc family toxin subunit TcaC tcbA tcbA Tc family toxin subunit TcbA tccC tccC Tc family toxin RHS repeat subunit TccC virF_Yersin virF virulence regulon transcriptional activator VirF yadA yadA NF033478.1 trimeric autotransporter adhesin YadA ymoA ymoA expression modulating protein YmoA yopB yopB type III secretion system translocon subunit YopB yopD yopD type III secretion system translocon subunit YopD yopE yopE type III secretion system effector GTPase activator YopE yopH yopH T3SS effector protein-tyrosine-phosphatase YopH yopJ_gen yopJ NF040632.1 YopJ/YopP family T3SS effector serine/threonine acetyltransferase yopM yopM type III secretion system effector YopM yopO yopO type III secretion system effector protein kinase YopO/YpkA yopT yopT T3SS effector cysteine protease YopT ystA ystA ST-I family heat-stable enterotoxin YstA ystB ystB ST-I family heat-stable enterotoxin YstB ystC ystC ST-I family heat-stable enterotoxin YstC Changed Hierarchy Nodes ADAPTIVE node_id: ADAPTIVE -> AMR-SUSCEPTIBLE name: Families implicated in Adaptive resistance by mutuation -> Families implicated in adaptive resistance by mutation bla-A_carba carbapenem-hydrolyzing class A beta-lactamase subclass: BETA-LACTAM -> CARBAPENEM blaCME CME family class A extended-spectrum beta-lactamase subclass: BETA-LACTAM -> CEPHALOSPORIN dfrC trimethoprim-sensitive dihydrofolate reductase DfrC class: TRIMETHOPRIM -> hmm_acc: NF000155.1 -> name: trimethoprim-resistant dihydrofolate reductase DfrC -> trimethoprim-sensitive dihydrofolate reductase DfrC scope: core -> non-reported subclass: TRIMETHOPRIM -> pbp penicillin-binding protein parent_node_id: ADAPTIVE -> AMR-SUSCEPTIBLE subtype: -> AMR-SUSCEPTIBLE type: -> AMR pbp1a penicillin-binding protein subtype: -> AMR-SUSCEPTIBLE type: -> AMR pbp2b penicillin-binding protein subtype: -> AMR-SUSCEPTIBLE type: -> AMR pbp2x penicillin-binding protein subtype: -> AMR-SUSCEPTIBLE type: -> AMR ---------------------------------------------------------------------- Changes included in 2021-09-30.1 ---------------------------------------------------------------------- NOTE: This database release requires AMRFinderPlus 3.10.16. If you are using an older version of the software it will not work with this database version. To upgrade AMRFinderPlus to version 3.10.16 see the Upgrading instructions on the wiki: https://github.com/ncbi/amr/wiki/Upgrading Overview - The usual addition of new alleles and genes as they are submitted for allele assignment or discovered in the literature. - A reorganization of the blaOXA family structure. Many gene names have changed to include/clarify family structure information, but allele and gene symbols have not changed. - Curators reviewed and added many new known point mutations to the taxgroups we cover. - Added point mutations for Clostridioides difficile. - The previously reportable Enterococcus faecium eat(A) was made not-reportable and point mutations associated with resistance were added because the reference appears to be sensitive. - Many refinements of "Subclass" information on resistance spectrum based on recent literature. - FosA naming regularization and reorganization (see curator statement below for details). - A few new families and HMMs (e.g., blaSFC, blaCRP). - Subclasses with multiple resistances are now presented in alphabetical order. - The gene associated with the symbol DfrE has changed (see curator statement below for details). - A bug in the code generating the Reference Gene Catalog meant that fusion genes sometimes did not include all subclasses for both subunits. This only affected the Reference Gene Catalog; AMRFinderPlus results continue to include the subclasses for both subunits. - We added a new hierarchy_node field in the Reference Gene Catalog along with a new file ReferenceGeneHierarchy.txt that contains information on the gene hierarchy behind the AMRFinderPlus algorithm. This data will be behind a new web interface and is a more user-friendly version of some of the data contained in the AMRFinderPlus database files. - A couple of aac(6') sequences were removed because the DNA sequences behind them were withdrawn at the request of the submitter and substitutes could not be found. - A blaOXA-664 allele was removed because the sequence is not complete and it was not found on any genomes in our system. Curator statement concerning FosA nomenclature changes NCBI has improved the annotation of FosA proteins closely related to named protein alleles FosA5 and FosA6. The names FosA9 and FosA10 may have conflicting meanings in the literature, but have been entered into our database as the terms are used in PMID:31511878 and PMID:32431524, respectively, and then cited in more recent publications. We note that the family of FosA proteins closely related to FosA5, FosA6, FosA9, and FosA10, which generally shows pairwise amino acid identity above 94 % between any two members, has grown to include now over 200 different amino acid sequences, the majority of which NCBI is giving the protein product name "FosA5 family fosfomycin resistance glutathione transferase." A new HMM, NF040540, identifies and names members of the FosA5 family. NCBI recommends against inventing any further allele names for the FosA5 family, as collisions can and do occur when researchers attempt to identify the next available unused name, and recommends that a protein accession number be used instead to refer to specific members of the family. New names in the FosA series should be reserved for the purpose of discussing novel families, as was done with FosA7, founding member of the FosA7 family. Curator statement concerning DfrE changes The dihydrofolate reductase given the name "DfrE" in PMID:9869579 (1999) was properly described there as the typical enzyme intrinsic to Enterococcus faecalis, sensitive to trimethoprim and incapable of conferring trimethopim resistance. It has now been removed from the Reference Gene Catalog. Note that PMID:9869579 also described DfrF, which does confer resistance and which remains in our database. A more recent article, PMID:34374564 (August 2021) describes a newly characterized mobile enzyme, observed first in Staphylococcus sciuri and shown capable of conferring strong resistance to trimethoprim, and given the name DfrE. Starting with this release, AMRFinderPlus will use the term DfrE only to refer to the newly described, resistance-conferring enzyme described in PMID:34374564. Summary: Total proteins: 6914 Core proteins: 5921 Plus proteins: 992 AMR proteins: 5965 STRESS proteins: 233 VIRULENCE proteins: 716 Point mutations: 914 Point mutation references: 156 Point mutation organism groups: Acinetobacter_baumannii, Campylobacter, Clostridioides_difficile, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 650 Updates since release 2021-08-11.1: Proteins added: 66 Core proteins added: 46 Plus proteins added: 19 AMR proteins added: 47 STRESS proteins added: 2 VIRULENCE proteins added: 17 Alleles added: 44 Point mutations added: 62 Proteins removed: 5 Core proteins removed: 5 Reference Gene Catalog entries changed: 339 Families added: 93 Families removed: 76 Families changed: 19 Added proteins core AMR AMR dfrE NG_076809.1 WP_012655890.1 trimethoprim-resistant dihydrofolate reductase DfrE blaRSA1 NG_076853.1 WP_216944871.1 RSA1 family class A beta-lactamase blaFRI-11 NG_076847.1 WP_223174987.1 carbapenem-hydrolyzing class A beta-lactamase FRI-11 blaGOB-52 NG_067223.1 WP_159108984.1 subclass B3 metallo-beta-lactamase GOB-52 blaIMI-22 NG_076848.1 WP_223174988.1 carbapenem-hydrolyzing class A beta-lactamase IMI-22 blaNDM-39 NG_076842.1 WP_223146983.1 subclass B1 metallo-beta-lactamase NDM-39 blaNDM-40 NG_076843.1 WP_223146984.1 subclass B1 metallo-beta-lactamase NDM-40 blaOXA-1011 NG_076852.1 WP_211816370.1 class D beta-lactamase OXA-1011 blaOXA-1018 NG_076815.1 WP_223146972.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1018 blaOXA-1019 NG_076816.1 WP_196658681.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1019 blaOXA-1020 NG_076817.1 WP_126584556.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1020 blaOXA-1021 NG_076818.1 WP_121306048.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1021 blaOXA-1022 NG_076819.1 WP_034027761.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1022 blaOXA-1023 NG_076820.1 WP_034033411.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1023 blaOXA-1024 NG_076821.1 WP_058354753.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1024 blaOXA-1025 NG_076822.1 WP_034025854.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1025 blaOXA-1026 NG_076823.1 WP_019396295.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1026 blaOXA-1027 NG_076824.1 WP_058142895.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1027 blaOXA-1028 NG_076825.1 WP_017002439.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1028 blaOXA-1029 NG_076826.1 WP_126861771.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1029 blaOXA-1030 NG_076827.1 WP_023097100.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1030 blaOXA-1031 NG_076828.1 WP_223146973.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1031 blaOXA-1032 NG_076829.1 WP_023107469.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1032 blaOXA-1033 NG_076830.1 WP_033937969.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1033 blaOXA-1034 NG_076831.1 WP_033887259.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1034 blaOXA-1035 NG_076840.1 WP_023096365.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1035 blaOXA-1036 NG_076807.1 WP_104442312.1 carbapenem-hydrolyzing class D beta-lactamase OXA-1036 blaOXA-1037 NG_076812.1 WP_128296272.1 class D beta-lactamase OXA-1037 blaPDC-489 NG_076832.1 WP_223146974.1 class C beta-lactamase PDC-489 blaPDC-490 NG_076833.1 WP_223146975.1 class C beta-lactamase PDC-490 blaPDC-491 NG_076834.1 WP_223146976.1 class C beta-lactamase PDC-491 blaPDC-492 NG_076835.1 WP_223146977.1 class C beta-lactamase PDC-492 blaPDC-493 NG_076836.1 WP_223146978.1 class C beta-lactamase PDC-493 blaPDC-494 NG_076837.1 WP_223146979.1 class C beta-lactamase PDC-494 blaPDC-495 NG_076838.1 WP_223146980.1 class C beta-lactamase PDC-495 blaPDC-496 NG_076839.1 WP_223146981.1 class C beta-lactamase PDC-496 blaRAA-1 NG_076814.1 WP_061710074.1 extended-spectrum beta-lactamase RAA-1 blaRSA1-1 NG_076854.1 WP_223292485.1 class A beta-lactamase RSA1-1 blaSFC-2 NG_076846.1 WP_223174986.1 carbapenem-hydrolyzing class A beta-lactamase SFC-2 blaSHV-122b NG_076808.1 WP_223146970.1 class A beta-lactamase SHV-122b blaSHV-229 NG_076841.1 WP_223146982.1 class A broad-spectrum beta-lactamase SHV-229 blaTEM-61 NG_076810.1 WP_188240090.1 class A extended-spectrum beta-lactamase TEM-61 blaVIM-75 NG_076844.1 WP_213556171.1 subclass B1 metallo-beta-lactamase VIM-75 blaVIM-76 NG_076811.1 WP_223146971.1 subclass B1 metallo-beta-lactamase VIM-76 fosA9 NG_076845.1 WP_114473955.1 fosfomycin resistance glutathione transferase FosA9 qnrB89 NG_076813.1 WP_213133914.1 quinolone resistance pentapeptide repeat protein QnrB89 non-reported AMR AMR eat(A) CP003351.1 AFC62715.1 ABC-F type ribosomal protection-like protein Eat(A) plus STRESS METAL merB1 AF138877.1 AAA83978.1 organomercurial lyase MerB1 merB1 LC152290.1 BAA82061.2 organomercurial lyase MerB1 plus VIRULENCE VIRULENCE etx M80837.1 AAA23235.1 epsilon toxin type B cpe M98037.1 AAA72120.1 enterotoxin CPE cpb2 L77965.1 AAC27654.1 beta-2 toxin CPB2 cpb2 AY609165.1 AAU14850.1 beta-2 toxin CPB2 cpb2 AY730636.1 AAW66356.1 beta-2 toxin CPB2 pfoA EF165974.1 ABM21538.1 cholesterol-dependent cytolysin perfringolysin O netB EU143239.1 ABW71134.1 necrotizing enteritis toxin NetB cpd EU545552.1 ACD67884.1 beta-channel forming cytolysin CPD cpb KP064404.1 AJI77134.1 beta-channel forming cytolysin CPB netF KP739975.1 AKF16652.1 necrotizing enteritis toxin NetF becA MH900565.1 AYA44302.1 ADP-ribosylating binary toxin enzymatic subunit BecA becB MH900565.1 AYA44303.1 ADP-ribosylating binary toxin binding subunit BecB cpa D32126.1 BAA06852.1 alpha-toxin tpeL AB262081.1 BAF46125.1 glycosylating toxin TpeL iap X73562.1 CAA51959.1 ADP-ribosylating binary toxin iota enzymatic subunit Ia ibp X73562.1 CAA51960.1 ADP-ribosylating binary toxin iota binding subunit Ib Added point mutations core AMR POINT 23S_C658T CLINDAMYCIN/ERYTHROMYCIN Clostridioides_difficile cdsA_D222N DAPTOMYCIN Streptococcus_pneumoniae eatA_T450I PLEUROMUTILIN Enterococcus_faecium fabI_F203V TRICLOSAN Escherichia fabI_M159T TRICLOSAN Escherichia ftsI_I336IKYRI AZTREONAM Escherichia ftsI_I336IPYRI AZTREONAM Escherichia ftsI_N337NYRIN AZTREONAM Escherichia fusA_H457L FUSIDIC ACID Staphylococcus_aureus fusA_H457N FUSIDIC ACID Staphylococcus_aureus glpT_A100V FOSFOMYCIN Staphylococcus_aureus glpT_E448K FOSFOMYCIN Escherichia glpT_W355STOP FOSFOMYCIN Staphylococcus_aureus gyrA_A118S QUINOLONE Clostridioides_difficile gyrA_A118T QUINOLONE Clostridioides_difficile gyrA_A384D QUINOLONE Clostridioides_difficile gyrA_D71G QUINOLONE Clostridioides_difficile gyrA_D71V QUINOLONE Clostridioides_difficile gyrA_D81N QUINOLONE Clostridioides_difficile gyrA_E88A QUINOLONE Staphylococcus_aureus gyrA_T82A QUINOLONE Clostridioides_difficile gyrA_T82I QUINOLONE Clostridioides_difficile gyrA_T82V QUINOLONE Clostridioides_difficile gyrB_D426N QUINOLONE Clostridioides_difficile gyrB_D426V QUINOLONE Clostridioides_difficile gyrB_E466K QUINOLONE Clostridioides_difficile gyrB_E466V QUINOLONE Clostridioides_difficile gyrB_I139R QUINOLONE Clostridioides_difficile gyrB_R377G QUINOLONE Clostridioides_difficile gyrB_R447K QUINOLONE Clostridioides_difficile gyrB_R447L QUINOLONE Clostridioides_difficile gyrB_S366A QUINOLONE Clostridioides_difficile gyrB_S366V QUINOLONE Clostridioides_difficile gyrB_S416A QUINOLONE Clostridioides_difficile gyrB_V130I QUINOLONE Clostridioides_difficile lpxA_D233STOP COLISTIN Acinetobacter_baumannii lpxA_G68D COLISTIN Acinetobacter_baumannii lpxA_H159D COLISTIN Acinetobacter_baumannii lpxA_Q72K COLISTIN Acinetobacter_baumannii lpxC_P30L COLISTIN Acinetobacter_baumannii mexZ_G46S CEPHALOSPORIN Pseudomonas_aeruginosa mexZ_Q10STOP CEPHALOSPORIN Pseudomonas_aeruginosa mexZ_V43A CEPHALOSPORIN Pseudomonas_aeruginosa murA_L42STOP FOSFOMYCIN Staphylococcus_aureus murG_P107L VANCOMYCIN Clostridioides_difficile nfsA_E223STOP NITROFURANTOIN Escherichia ompK36_G133D CARBAPENEM Klebsiella pbp4_E218K CEPHALOSPORIN Staphylococcus_aureus pbp4_R200L CEPHALOSPORIN Staphylococcus_aureus pbp4_T-266A CEPHALOSPORIN Staphylococcus_aureus rpoB_D492N RIFAXIMIN Clostridioides_difficile rpoB_D492V RIFAXIMIN Clostridioides_difficile rpoB_H502L RIFAXIMIN Clostridioides_difficile rpoB_H502N RIFAMPIN Clostridioides_difficile rpoB_H502Y RIFAXIMIN Clostridioides_difficile rpoB_P496S RIFAMYCIN Clostridioides_difficile rpoB_Q1074R FIDAXOMICIN Clostridioides_difficile rpoB_R505K RIFAMPIN Clostridioides_difficile rpoB_S488P RIFAMYCIN Clostridioides_difficile rpoB_S550F RIFAXIMIN Clostridioides_difficile rpoB_S550Y RIFAXIMIN Clostridioides_difficile rpoC_D245Y VANCOMYCIN Clostridioides_difficile Removed proteins core AMR AMR eat(A) NG_047762.1 WP_002296175.1 ABC-F type ribosomal protection protein Eat(A) (moved to non-reported, NG_ record removed) dfrE NG_055770.1 WP_010710386.1 trimethoprim-resistant dihydrofolate reductase DfrE aac(6') NG_052532.1 WP_018893623.1 aminoglycoside 6'-N-acetyltransferase aac(6') NG_052293.1 WP_037790839.1 aminoglycoside 6'-N-acetyltransferase blaOXA-664 NG_062213.1 WP_016168805.1 carbapenem-hydrolyzing class D beta-lactamase OXA-664 Changed reference gene catalog records lmrS AAW38464.1 subclass: ERYTHROMYCIN/CHLORAMPHENICOL -> CHLORAMPHENICOL/ERYTHROMYCIN arsR AET17094.1 class: -> ARSENIC subclass: -> ARSENIC glpT_F3I WP_001010111.1 refseq_protein_accession: WP_001010116.1 -> WP_001010111.1 glpT_G352D WP_001010111.1 refseq_protein_accession: WP_001010116.1 -> WP_001010111.1 glpT_L27F WP_001010111.1 refseq_protein_accession: WP_001010116.1 -> WP_001010111.1 glpT_V213I WP_001010111.1 refseq_protein_accession: WP_001010116.1 -> WP_001010111.1 glpT_W137R WP_001010111.1 refseq_protein_accession: WP_001010116.1 -> WP_001010111.1 cfr WP_001010505.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN aac(6')-Ie/aph(2'')-Ia WP_001028144.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN ant(3'')-IIa WP_001112624.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN ant(3'')-IIa WP_001279062.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN ant(3'')-IIa WP_001279068.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN ant(3'')-IIa WP_001279073.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN cfr(B) WP_002349981.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN cfr(B) WP_002405682.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN fosA WP_004146118.1 product_name: FosA family fosfomycin resistance glutathione transferase -> FosA5 family fosfomycin resistance glutathione transferase ant(3'')-IIc WP_004680079.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN ant(3'')-IIc WP_004758588.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN ant(3'')-IIb WP_004773276.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN ant(3'')-IIc WP_005001597.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN fos WP_005475717.1 product_name: FosG/FosC2 family fosfomycin resistance glutathione transferase -> FosG/FosC2-related fosfomycin resistance glutathione transferase fosA WP_009486251.1 product_name: FosA family fosfomycin resistance glutathione transferase -> FosA5 family fosfomycin resistance glutathione transferase clbB WP_011245929.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN cfr WP_011987126.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN clbA WP_012116915.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN aac(6')-Ie/aph(2'')-Ia WP_012655884.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN ant(3'')-IIa WP_014208115.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN cipA WP_015735625.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN clbC WP_015892743.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN vanA-Ao2 WP_016331865.1 gene_family: vanAo2 -> vanA-Ao2 aac(6')-Ie/aph(2'')-Ia WP_032490744.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN cfr WP_032491462.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN aadA27 WP_050041693.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN aac(6')-Ie/aph(2'')-If2 WP_057097547.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN aac(3)-Ib/aac(6')-Ib'' WP_063838852.1 subclass: KANAMYCIN/TOBRAMYCIN -> GENTAMICIN/KANAMYCIN/TOBRAMYCIN aac(6')-30/aac(6')-Ib' WP_063838853.1 subclass: GENTAMICIN -> AMINOGLYCOSIDE/GENTAMICIN ant(3'')-Ij/aac(6')-Ib WP_063839875.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> GENTAMICIN/SPECTINOMYCIN/STREPTOMYCIN ant(3'')-Ih/aac(6')-IId WP_063839878.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> AMINOGLYCOSIDE/SPECTINOMYCIN/STREPTOMYCIN arr WP_063842202.1 product_name: NAD(+)--rifampin ADP-ribosyltransferase -> NAD(+)--rifampin ADP-ribosyltransferase Arr-2b rgt WP_063854815.1 product_name: rifamycin-inactivating glycosyltransferase Rgt -> Rgt1438 family rifamycin-inactivating glycosyltransferase vanY-N WP_063856825.1 gene_family: vanY -> vanY-N product_name: VanY-like protein -> D,D-peptidase/D,D-carboxypeptidase VanY-N ant(3'')-Ij/aac(6')-IIa WP_070342373.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> GENTAMICIN/KANAMYCIN/SPECTINOMYCIN/STREPTOMYCIN/TOBRAMYCIN catB8/aac(6')-Ib' WP_071593228.1 class: AMINOGLYCOSIDE -> AMINOGLYCOSIDE/PHENICOL subclass: GENTAMICIN -> AMINOGLYCOSIDE/CHLORAMPHENICOL/GENTAMICIN aac(6')-Ib-cr WP_071846215.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN ant(3'')-Ia WP_071846263.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN ant(3'')-Ia WP_071846264.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN ant(3'')-Ia WP_071846265.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN cfr(E) WP_105119688.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN cfr(D) WP_105459893.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN cfr(B) WP_111690897.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN cfr(C) WP_111690898.1 class: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN subclass: MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN aac(6')-Ie/aph(2'') WP_122630840.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN ant(3'')-Ib WP_149316740.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN 16S_C1191T NZ_AP019853.2 pubmed_reference: -> 2138078 23S_A2045G NC_002946.2 pubmed_reference: -> 20585125 23S_A2057G NC_002946.2 pubmed_reference: -> 30917979 23S_A2114G NZ_CP018347.1 pubmed_reference: -> 10898684 23S_A2115G NZ_CP018347.1 pubmed_reference: -> 10898684 23S_A2118G NZ_CP018347.1 pubmed_reference: -> 11120988 23S_A2145G NC_002946.2 pubmed_reference: -> 31040249 23S_C2597T NC_002946.2 pubmed_reference: -> 12183262 23S_C2630A NZ_CP018347.1 pubmed_reference: -> 10898684 23S_C2630G NZ_CP018347.1 pubmed_reference: -> 10898684 aac(6')-Ib-cr10 WP_124042715.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN aac(6')-Ib-cr11 WP_159241551.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN aac(6')-Ib-cr3 WP_071766621.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN aac(6')-Ib-cr4 WP_065187000.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN aac(6')-Ib-cr5 WP_063840321.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN aac(6')-Ib-cr6 WP_063840320.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN aac(6')-Ib-cr7 WP_071766399.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN aac(6')-Ib-cr8 WP_151346866.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN aac(6')-Ib-cr9 WP_131534982.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN aadA14 WP_011264082.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN aadA17 WP_063840416.1 subclass: STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN acrB_R620C WP_086259262.1 pubmed_reference: -> 30519062 acrB_R717L WP_001132507.1 pubmed_reference: -> 31730615 acrB_R717Q WP_001132507.1 pubmed_reference: -> 31730615 acrR_M109I WP_002892080.1 pubmed_reference: -> 25182649 acrR_V165I WP_002892080.1 pubmed_reference: -> 25182649 acrR_Y114F WP_002892080.1 pubmed_reference: -> 25182649 adeR_A91V WP_031379794.1 pubmed_reference: -> 27247231 adeR_D20N WP_031379794.1 pubmed_reference: -> 20921306 adeR_E219A WP_031379794.1 pubmed_reference: -> 23587960 adeR_L192R WP_031379794.1 pubmed_reference: -> 23587960 adeR_P116L WP_031379794.1 pubmed_reference: -> 15328088 adeR_P56S WP_031379794.1 pubmed_reference: -> 23587960 adeS_G336S WP_031379793.1 pubmed_reference: -> 23587960 adeS_H189Y WP_031379793.1 pubmed_reference: -> 23587960 adeS_I252S WP_031379793.1 pubmed_reference: -> 23587960 adeS_N125K WP_031379793.1 pubmed_reference: -> 23587960 adeS_Q163STOP WP_031379793.1 pubmed_reference: -> 23587960 adeS_R152K WP_031379793.1 pubmed_reference: -> 23587960 adeS_T153M WP_031379793.1 pubmed_reference: -> 15328088 ampC_C-11T NZ_CP041538.1 pubmed_reference: -> 12234856 ampC_C-42A NZ_CP041538.1 pubmed_reference: -> 21653764, 7010184 ampC_C-42G NZ_CP041538.1 pubmed_reference: -> 21653764, 7010184 ampC_C-42T NZ_CP041538.1 pubmed_reference: -> 21653764, 7010184 ampC_T-32A NZ_CP041538.1 pubmed_reference: -> 21653764, 7010184 ampC_T-32C NZ_CP041538.1 pubmed_reference: -> 21653764, 7010184 ampC_T-32G NZ_CP041538.1 pubmed_reference: -> 21653764, 7010184 ampD_H77Y WP_003112844.1 pubmed_reference: -> 27736752 ampD_T139M WP_003112844.1 pubmed_reference: -> 27736752 ampR_D135G WP_003137572.1 pubmed_reference: -> 25182487 ampR_G154R WP_003137572.1 pubmed_reference: -> 23045355 basR_G15R WP_094970923.1 pubmed_reference: -> 30863849 basR_G53A WP_094970923.1 pubmed_reference: -> 30863849 basR_G53C WP_094970923.1 pubmed_reference: -> 30863849 basR_G53E WP_094970923.1 pubmed_reference: -> 30863849 basR_G53R WP_094970923.1 pubmed_reference: -> 30863849 basR_G53S WP_094970923.1 pubmed_reference: -> 30863849 basR_G53V WP_094970923.1 pubmed_reference: -> 30863849 basR_G53W WP_094970923.1 pubmed_reference: -> 30863849 basR_L105P WP_094970923.1 pubmed_reference: -> 29914952 basR_R81L WP_094970923.1 pubmed_reference: -> 30863849 blaB-28 WP_107808007.1 genbank_nucleotide_accession: QAXV01000003.1 -> QBUH01000004.1 refseq_nucleotide_accession: NG_067981.1 -> NG_076849.1 blaGES-15 WP_063860503.1 product_name: carbapenem-hydrolyzing class A beta-lactamase GES-15 -> class A extended-spectrum beta-lactamase GES-15 pubmed_reference: -> 34125593 subclass: CARBAPENEM -> CEPHALOSPORIN blaGOB-34 WP_107809858.1 genbank_nucleotide_accession: QAXV01000011.1 -> QBUH01000010.1 genbank_protein_accession: PTW00275.1 -> PUB26722.1 refseq_nucleotide_accession: NG_068000.1 -> NG_076850.1 blaKPC-29 WP_096807439.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-29 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-29 pubmed_reference: -> 34339281 blaKPC-31 WP_073668892.1 product_name: inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-31 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-31 pubmed_reference: -> 34339281 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-66 WP_188331871.1 pubmed_reference: -> 34339281 blaKPC-67 WP_210204487.1 product_name: class A beta-lactamase KPC-67 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-67 pubmed_reference: -> 34339281 blaKPC-68 WP_210204468.1 product_name: class A beta-lactamase KPC-68 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-68 pubmed_reference: -> 34339281 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-70 WP_210205477.1 product_name: class A beta-lactamase KPC-70 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-70 pubmed_reference: -> 34339281 subclass: CARBAPENEM -> CEPHALOSPORIN blaOXA-118 WP_063861020.1 product_name: oxacillin-hydrolyzing class D beta-lactamase OXA-118 -> OXA-46 family oxacillin-hydrolyzing class D beta-lactamase OXA-118 blaOXA-119 WP_032490445.1 product_name: oxacillin-hydrolyzing class D beta-lactamase OXA-119 -> OXA-46 family oxacillin-hydrolyzing class D beta-lactamase OXA-119 blaOXA-185 WP_063861300.1 product_name: OXA-184 class D beta-lactamase OXA-185 -> OXA-184 family class D beta-lactamase OXA-185 blaOXA-205 WP_063861588.1 product_name: oxacillin-hydrolyzing class D beta-lactamase OXA-205 -> OXA-46 family oxacillin-hydrolyzing class D beta-lactamase OXA-205 blaOXA-427 WP_096807440.1 pubmed_reference: -> 34427311 blaOXA-43 WP_063862921.1 product_name: oxacillin-hydrolyzing class D beta-lactamase OXA-43 -> OXA-42 family oxacillin-hydrolyzing class D beta-lactamase OXA-43 blaOXA-57 WP_004547230.1 product_name: oxacillin-hydrolyzing class D beta-lactamase OXA-57 -> OXA-42 family oxacillin-hydrolyzing class D beta-lactamase OXA-57 blaOXA-59 WP_004524931.1 product_name: oxacillin-hydrolyzing class D beta-lactamase OXA-59 -> OXA-42 family oxacillin-hydrolyzing class D beta-lactamase OXA-59 blaOXA-896 WP_156404658.1 product_name: class D beta-lactamase OXA-896 -> OXA-9 family oxacillin-hydrolyzing class D beta-lactamase OXA-896 blaOXA-917 WP_161507793.1 product_name: carbapenem-hydrolyzing class D beta-lactamase OXA-917 -> OXA-427 family carbapenem-hydrolyzing class D beta-lactamase OXA-917 blaSIM-1 WP_017901052.1 pubmed_reference: 16251286 -> 16251286, 34339276 subclass: BETA-LACTAM -> CARBAPENEM blaSIM-2 WP_063864722.1 pubmed_reference: -> 34339276 subclass: BETA-LACTAM -> CARBAPENEM blaSPR-1 WP_012145975.1 subclass: CARBAPENEM -> BETA-LACTAM cvaC CAA40746.1 genbank_protein_accession: P22522.1 -> CAA40746.1 genbank_nucleotide_accession: -> X57525.1 dacB_G437D WP_003091272.1 pubmed_reference: -> 30189050 dacB_T428P WP_003091272.1 pubmed_reference: -> 30189050, 32814972 dacB_W459STOP WP_003091272.1 pubmed_reference: -> 30189050 emrR_L113P WP_000378442.1 pubmed_reference: -> 31633764 emrR_L64R WP_000378442.1 pubmed_reference: -> 31633764 folP_F25I WP_011017740.1 pubmed_reference: -> 9593127 folP_R228S WP_003702942.1 pubmed_reference: -> 15673729 fosA10 WP_004214174.1 allele: -> fosA10 product_name: FosA family fosfomycin resistance glutathione transferase -> fosfomycin resistance glutathione transferase FosA10 ftsI_A515V WP_000227936.1 pubmed_reference: -> 29547094 glpT_T211P WP_003096330.1 pubmed_reference: -> 27736752 grlA_D84G WP_019167736.1 pubmed_reference: -> 18305127 grlA_D84H WP_019167736.1 pubmed_reference: -> 18305127 grlA_D84N WP_019167736.1 pubmed_reference: -> 18305127 grlA_D84Y WP_019167736.1 pubmed_reference: -> 18305127 grlA_S80I WP_019167736.1 pubmed_reference: -> 18305127 grlA_S80R WP_019167736.1 pubmed_reference: -> 18305127 gyrA_A119E WP_001281271.1 pubmed_reference: -> 15848289 gyrA_A119S WP_001281271.1 pubmed_reference: -> 15848289 gyrA_A119V WP_001281271.1 pubmed_reference: -> 15848289 gyrA_A131G WP_001281271.1 pubmed_reference: -> 15848289 gyrA_A67P WP_001281271.1 pubmed_reference: -> 15848289 gyrA_D72G WP_001281271.1 pubmed_reference: -> 15848289 gyrA_D82G WP_001281271.1 pubmed_reference: -> 15848289 gyrA_D82N WP_001281271.1 pubmed_reference: -> 15848289 gyrA_D87G WP_001281271.1 pubmed_reference: -> 15848289 gyrA_D87G WP_003091448.1 pubmed_reference: -> 8540700 gyrA_D87H WP_003091448.1 pubmed_reference: -> 8540700 gyrA_D87K WP_001281271.1 pubmed_reference: -> 15848289 gyrA_D87N WP_001281271.1 pubmed_reference: -> 15848289 gyrA_D87N WP_003091448.1 pubmed_reference: -> 8540700 gyrA_D87Y WP_001281271.1 pubmed_reference: -> 15848289 gyrA_D95A WP_003688895.1 pubmed_reference: -> 7830580 gyrA_D95G WP_003688895.1 pubmed_reference: -> 7830580 gyrA_D95N WP_003688895.1 pubmed_reference: -> 7830580 gyrA_E139A WP_001281271.1 pubmed_reference: -> 15848289 gyrA_E88G WP_103263503.1 pubmed_reference: -> 18305127 gyrA_E88K WP_103263503.1 pubmed_reference: -> 18305127 gyrA_G79C WP_000116450.1 pubmed_reference: -> 15282231 gyrA_G81C WP_001281271.1 pubmed_reference: -> 15848289 gyrA_G81D WP_001281271.1 pubmed_reference: -> 15848289 gyrA_G81H WP_001281271.1 pubmed_reference: -> 15848289 gyrA_G81S WP_001281271.1 pubmed_reference: -> 15848289 gyrA_H80R WP_003091448.1 pubmed_reference: -> 22821356 gyrA_L98V WP_001281271.1 pubmed_reference: -> 15848289 gyrA_S81L WP_000116450.1 pubmed_reference: -> 15282231 gyrA_S83A WP_001281271.1 pubmed_reference: -> 15848289 gyrA_S83F WP_001281271.1 pubmed_reference: -> 15848289 gyrA_S83I WP_001281271.1 pubmed_reference: -> 33877914 gyrA_S83Y WP_001281271.1 pubmed_reference: -> 15848289 gyrA_S84A WP_103263503.1 pubmed_reference: -> 18305127 gyrA_S84L WP_103263503.1 pubmed_reference: -> 18305127 gyrA_S84W WP_103263503.1 pubmed_reference: -> 18305127 gyrA_S85A WP_103263503.1 pubmed_reference: -> 18305127 gyrA_S91F WP_003688895.1 pubmed_reference: -> 7830580 gyrA_S97P WP_001281271.1 pubmed_reference: -> 27559761 gyrA_T83I WP_003091448.1 pubmed_reference: -> 8540700 gyrA_V73I WP_001281271.1 pubmed_reference: -> 15848289 gyrB_D429N WP_050171206.1 pubmed_reference: -> 31730160 gyrB_E466D WP_000072047.1 pubmed_reference: -> 19104017 gyrB_K450N WP_050171206.1 pubmed_reference: -> 31730160 gyrB_K450T WP_050171206.1 pubmed_reference: -> 31730160 gyrB_R438L WP_000072047.1 pubmed_reference: -> 15848289 gyrB_Y421C WP_000072047.1 pubmed_reference: -> 15848289 lon_P403L WP_001295325.1 pubmed_reference: -> 30519062 macAB_G-48T NZ_AP023073.1 pubmed_reference: -> 16162665 marR_R77L WP_000843414.1 pubmed_reference: -> 8383113 mexB_V45L WP_003107312.1 pubmed_reference: -> 27736752 mexD_Q178R WP_003112801.1 pubmed_reference: -> 34060900 mexD_S133G WP_003112801.1 pubmed_reference: -> 34060900 mexZ_G195E WP_003088626.1 pubmed_reference: -> 23045355 mtrC_C-120T NZ_CP012026.1 pubmed_reference: -> 21933917 mtrR_A-53del NZ_CP043871.1 pubmed_reference: -> 12493797, 12270819, 30087172 mtrR_A-56C NZ_CP043871.1 pubmed_reference: -> 30087172 mtrR_A39T WP_047924300.1 pubmed_reference: -> 18761689 mtrR_G-131A NZ_CP043871.1 pubmed_reference: -> 18761689 mtrR_G45D WP_047924300.1 pubmed_reference: -> 18761689 norM_A-7G NZ_AP023073.1 pubmed_reference: -> 12533487 norM_C-104T NZ_AP023073.1 pubmed_reference: -> 12533487 ompK35_E132K WP_004141771.1 pubmed_reference: -> 20660684 ompK35_W230STOP WP_004141771.1 pubmed_reference: -> 34060914 ompK36_D135DGD WP_002913005.1 pubmed_reference: -> 30875398, 31477712 ompK36_E78STOP WP_002913005.1 pubmed_reference: -> 20660684 ompK36_T126STOP WP_002913005.1 pubmed_reference: -> 20660684 ompK36_T136TDT WP_002913005.1 pubmed_reference: -> 30875398, 31477712 ompK36_T192del WP_002913005.1 pubmed_reference: -> 20660684 ompK36_T261STOP WP_002913005.1 pubmed_reference: -> 20660684 ompK36_T333N WP_002913005.1 pubmed_reference: -> 28739787 ompK36_W125STOP WP_002913005.1 pubmed_reference: -> 34060914 oprD_Q142STOP WP_003112576.1 pubmed_reference: -> 27736752 oprD_W138STOP WP_003112576.1 pubmed_reference: -> 27736752 oqxR_D95E WP_000888203.1 pubmed_reference: -> 22644028 oqxR_F6S WP_000888203.1 pubmed_reference: -> 22644028 oqxR_Q11L WP_000888203.1 pubmed_reference: -> 22644028 oqxR_V102G WP_000888203.1 pubmed_reference: -> 25193085 oqxR_V113I WP_000888203.1 pubmed_reference: -> 22644028 parC_D83H WP_001836116.1 pubmed_reference: -> 8913454 parC_D86N WP_010951227.1 pubmed_reference: -> 7830580 parC_E84G WP_001281910.1 pubmed_reference: -> 15848289 parC_E84K WP_001281910.1 pubmed_reference: -> 15848289 parC_E88K WP_000202259.1 pubmed_reference: -> 24159468 parC_E91G WP_010951227.1 pubmed_reference: -> 12529019 parC_E91K WP_010951227.1 pubmed_reference: -> 7830580 parC_G78D WP_001281910.1 pubmed_reference: -> 15848289 parC_S79F WP_001836116.1 pubmed_reference: -> 8913454 parC_S79Y WP_001836116.1 pubmed_reference: -> 8913454 parC_S80I WP_001281910.1 pubmed_reference: -> 15848289 parC_S80R WP_001281910.1 pubmed_reference: -> 15848289 parC_S84F WP_000202259.1 pubmed_reference: -> 24159468 parC_S84L WP_000202259.1 pubmed_reference: -> 27175500 parC_S84W WP_000202259.1 pubmed_reference: -> 24159468 parC_S87I WP_010951227.1 pubmed_reference: -> 7830580 parC_S87L WP_003095687.1 pubmed_reference: -> 31685471 parC_S87N WP_010951227.1 pubmed_reference: -> 7830580 parC_S87R WP_010951227.1 pubmed_reference: -> 7830580 parC_S88P WP_010951227.1 pubmed_reference: -> 7830580 parC_T66I WP_001281910.1 pubmed_reference: -> 15848289 parE_A473V WP_003102062.1 pubmed_reference: -> 23274661 parE_A499T WP_000195318.1 pubmed_reference: -> 15848289 parE_E454G WP_000195318.1 pubmed_reference: -> 15848289 parE_G410V WP_003691666.1 pubmed_reference: -> 12529019 parE_H462Y WP_000195318.1 pubmed_reference: -> 15848289 parE_M437I WP_003102062.1 pubmed_reference: -> 23274661 parE_M438I WP_000195318.1 pubmed_reference: -> 26683630 parE_S458P WP_000195318.1 pubmed_reference: -> 15848289 parE_V461G WP_000195318.1 pubmed_reference: -> 19104017 parE_V514G WP_000195318.1 pubmed_reference: -> 15848289 parE_V521F WP_000195318.1 pubmed_reference: -> 26683630 pbp2x_P601L WP_032462817.1 pubmed_reference: -> 31996443 pbp2x_Q557E WP_017647104.1 pubmed_reference: -> 18541727 penA_A311V WP_003693546.1 pubmed_reference: -> 23587946, 22155830 penA_A501AA WP_003693546.1 pubmed_reference: -> 34013864 penA_A501P WP_003693546.1 pubmed_reference: -> 20704258, 22155830 penA_A501T WP_003693546.1 pubmed_reference: -> 20704258, 23587946 penA_A501V WP_003693546.1 pubmed_reference: -> 20704258 penA_A510V WP_003693546.1 pubmed_reference: -> 27690121 penA_A516G WP_003693546.1 pubmed_reference: -> 27690121 penA_D346DD WP_003693546.1 pubmed_reference: -> 20704258, 23587946 penA_F504L WP_003693546.1 pubmed_reference: -> 27690121 penA_G542S WP_003693546.1 pubmed_reference: -> 20511367 penA_G545S WP_003693546.1 pubmed_reference: -> 20704258, 22155830 penA_I312M WP_003693546.1 pubmed_reference: -> 23587946, 20704258, 22155830 penA_N512Y WP_003693546.1 pubmed_reference: -> 27690121 penA_P551L WP_003693546.1 pubmed_reference: -> 20511367 penA_P551S WP_003693546.1 pubmed_reference: -> 20704258, 23587946 penA_T483S WP_003693546.1 pubmed_reference: -> 23587946 penA_V316P WP_003693546.1 pubmed_reference: -> 23587946 penA_V316T WP_003693546.1 pubmed_reference: -> 23587946, 20704258, 22155830 phoP_A110V WP_003082436.1 pubmed_reference: -> 24412662 phoP_R117L WP_003082436.1 pubmed_reference: -> 24412662 phoQ_K123Q WP_003082438.1 pubmed_reference: -> 24412662 phoQ_V260G WP_003082438.1 pubmed_reference: -> 24412662 pmrB_A159P WP_001300761.1 pubmed_reference: -> 30863849 pmrB_A159V WP_001300761.1 pubmed_reference: -> 30863849 pmrB_C84R WP_001300761.1 pubmed_reference: -> 30863849 pmrB_C84Y WP_001300761.1 pubmed_reference: -> 30863849 pmrB_E121K WP_001300761.1 pubmed_reference: -> 30863849 pmrB_E121Q WP_001300761.1 pubmed_reference: -> 30863849 pmrB_E166K WP_001300761.1 pubmed_reference: -> 30863849 pmrB_G206D WP_001300761.1 pubmed_reference: -> 29914952 pmrB_L10P WP_001300761.1 pubmed_reference: -> 30863849 pmrB_L10R WP_001300761.1 pubmed_reference: -> 30863849 pmrB_L14R WP_001300761.1 pubmed_reference: -> 30863849 pmrB_P94L WP_001300761.1 pubmed_reference: -> 30863849 pmrB_P94Q WP_001300761.1 pubmed_reference: -> 30863849 pmrB_P94S WP_001300761.1 pubmed_reference: -> 30863849 pmrB_T147A WP_001300761.1 pubmed_reference: -> 30863849 pmrB_T156M WP_001300761.1 pubmed_reference: -> 30863849 ponA_L421P WP_003687357.1 pubmed_reference: -> 11850260 porB1b_A121D WP_106333382.1 pubmed_reference: -> 12183233 porB1b_A121H WP_106333382.1 pubmed_reference: -> 12183233 porB1b_A121N WP_106333382.1 pubmed_reference: -> 12183233 porB1b_A121P WP_106333382.1 pubmed_reference: -> 12183233 porB1b_G120D WP_106333382.1 pubmed_reference: -> 12183233 porB1b_G120K WP_106333382.1 pubmed_reference: -> 12183233 porB1b_G120P WP_106333382.1 pubmed_reference: -> 12183233 porB1b_G120R WP_106333382.1 pubmed_reference: -> 12183233 ramR_A16D WP_004176968.1 pubmed_reference: -> 25182649 ramR_A183D WP_004176968.1 pubmed_reference: -> 25182649 ramR_A19V WP_004176968.1 pubmed_reference: -> 21514798 ramR_I88N WP_004176968.1 pubmed_reference: -> 25182649 ramR_K5E WP_004176968.1 pubmed_reference: -> 25182649 ramR_T162I WP_004176968.1 pubmed_reference: -> 25182649 ramR_T43M WP_004176968.1 pubmed_reference: -> 25182649 rplD_G70D WP_003690088.1 pubmed_reference: -> 33097713 rplV_K83KKGPSLK WP_002215424.1 pubmed_reference: -> 27638945 rplV_K90KARAK WP_002215424.1 pubmed_reference: -> 27638945 rpoB_A473AA WP_014614750.1 pubmed_reference: -> 18305127 rpoB_G158V WP_003690105.1 pubmed_reference: -> 32011233 rpoB_H481Y WP_014614750.1 pubmed_reference: -> 18305127 rpoB_P157L WP_003690105.1 pubmed_reference: -> 32011233 rpoB_R201H WP_003690105.1 pubmed_reference: -> 32011233 rpoB_S486L WP_014614750.1 pubmed_reference: -> 18305127 rpoC_F632S WP_000567963.1 product_name: DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoC rpoC_Q961K WP_000567963.1 product_name: DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoC rpoD_DDDA92del WP_003688264.1 pubmed_reference: -> 32011233 rpoD_E98K WP_003688264.1 pubmed_reference: -> 32011233 rpsE_K28E WP_002215445.1 pubmed_reference: -> 23183436 rpsE_T24P WP_002215445.1 pubmed_reference: -> 23183436 rpsE_V27del WP_002215445.1 pubmed_reference: -> 23183436 rpsJ_V57L WP_001181005.1 pubmed_reference: -> 30268919 rpsJ_V57L WP_002215394.1 pubmed_reference: -> 16189114 rpsJ_V57M WP_002215394.1 pubmed_reference: -> 16189114 rpsJ_V57Q WP_002215394.1 pubmed_reference: -> 16189114 Added families - - Acr3 family arsenite efflux transporter aph(2'') NF000076.3 APH(2'')-Ie/IVa family aminoglycoside O-phosphotransferase arr NF000066.1 NAD(+)--rifampin ADP-ribosyltransferase arr NF000318.1 NAD(+)--rifampin ADP-ribosyltransferase Arr-2b arsN1 NF040503.1 arsinothricin resistance N-acetyltransferase ArsN1 family A arsN1 NF040504.1 arsinothricin resistance N-acetyltransferase ArsN1 family B arsN2 NF040501.1 arsenic resistance N-acetyltransferase ArsN2 arsN - ArsN family N-acetyltransferase becA - ADP-ribosylating binary toxin enzymatic subunit BecA becB - ADP-ribosylating binary toxin binding subunit BecB blaADC - ADC-like cephalosporin-hydrolyzing class C beta-lactamase blaCTX-M - CTX-M-151 family class A beta-lactamase blaI - beta-lactamase repressor blaLRA10 - LRA10 family class C beta-lactamase blaLRA - LRA12 family subclass B3 metallo-beta-lactamase blaLRA18 - LRA18 family class C beta-lactamase blaLRA - LRA2 family subclass B3 metallo-beta-lactamase blaLRA - LRA3 family subclass B3 metallo-beta-lactamase blaOXA NF040529.1 OXA-1036 family class D beta-lactamase blaOXA NF000386.2 OXA-10 family class D beta-lactamase blaOXA NF033818.0 OXA-114 family class D beta-lactamase blaOXA NF033702.0 OXA-12 family class D beta-lactamase blaOXA NF000436.2 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000464.2 OXA-143 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000461.2 OXA-184 family class D beta-lactamase blaOXA NF000388.2 OXA-1 family class D beta-lactamase blaOXA NF000417.2 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000269.2 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000418.2 OXA-214 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000501.2 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF033509.1 OXA-22 family class D beta-lactamase blaOXA NF000266.2 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000434.2 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF033653.1 OXA-266 family class D beta-lactamase blaOXA NF033648.1 OXA-274 family class D beta-lactamase blaOXA NF000520.2 OXA-286 family class D beta-lactamase blaOXA NF038386.1 OXA-294 family class D beta-lactamase blaOXA NF000267.2 OXA-2 family class D beta-lactamase blaOXA NF033815.0 OXA-364 family class D beta-lactamase blaOXA NF000415.2 OXA-372 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF038217.1 OXA-427 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF040531.1 OXA-42 family class D beta-lactamase blaOXA NF033104.0 OXA-46 family oxacillin-hydrolyzing class D beta-lactamase blaOXA NF000387.2 OXA-48 family class D beta-lactamase blaOXA NF000462.2 OXA-493 family class D beta-lactamase blaOXA NF000432.2 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase blaOXA NF000268.2 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase blaOXA - OXA-542 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF040530.1 OXA-548 family class D beta-lactamase blaOXA NF033667.1 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF033613.1 OXA-576 family class D beta-lactamase blaOXA NF000500.2 OXA-58 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF040527.1 OXA-5 family class D beta-lactamase blaOXA NF000395.3 OXA-60 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000435.2 OXA-61 family class D beta-lactamase blaOXA NF000430.2 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000429.2 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase blaOXA NF038333.1 OXA-679 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF033666.1 OXA-727 family class D beta-lactamase blaOXA NF000502.2 OXA-85 family oxacillin-hydrolyzing class D beta-lactamase blaOXA NF038183.1 OXA-919 family class D beta-lactamase blaOXA NF040532.1 OXA-9 family class D beta-lactamase blaOXA NF000463.2 class D beta-lactamase blaRAA NF040467.1 RAA family extended-spectrum beta-lactamase blaRSA1 - RSA1 family class A beta-lactamase ble NF000028.1 BLMA family bleomycin binding protein cdtB - cytolethal distending toxin S-CDT copA - copper-translocating P-type ATPase CopA copB - copper/silver-translocating P-type ATPase CopB cpa - alpha-toxin cpb - beta-channel forming cytolysin CPB cpb2 - beta-2 toxin CPB2 cpd - beta-channel forming cytolysin CPD cpe - enterotoxin CPE etx - epsilon toxin type B fos - FosG/FosC2-related fosfomycin resistance glutathione transferase fosA NF040540.1 FosA5 family fosfomycin resistance glutathione transferase fosB NF000098.1 FosB family fosfomycin resistance bacillithiol transferase fosB NF000063.1 FosB family fosfomycin resistance bacillithiol transferase iap - ADP-ribosylating binary toxin iota enzymatic subunit Ia ibp - ADP-ribosylating binary toxin iota binding subunit Ib merB1 - organomercurial lyase MerB1 mtrA - efflux transporter MtrCDE transcriptional activator MtrA netB - necrotizing enteritis toxin NetB netF - necrotizing enteritis toxin NetF pfoA - cholesterol-dependent cytolysin perfringolysin O satA - streptothricin N-acetyltransferase SatA satA - streptothricin N-acetyltransferase SatA tpeL - glycosylating toxin TpeL vanA-Ao2 NF000092.1 D-alanine--(R)-lactate ligase VanA-Ao2 vanT NF033131.1 VanT-G-like membrane-bound serine racemase vanXY NF000149.1 D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-G vanY-N NF000086.1 D,D-peptidase/D,D-carboxypeptidase VanY-N Removed families ble NF000028.1 BLMA family bleomycin binding protein cdtB - cytolethal distending toxin S-CDT aac(6')-I - AAC(6')-Ighjkrstuvwx family aminoglycoside N-acetyltransferase aac(6') - AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase aadA1a - ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1a aadA2ah - ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA2ah aadA2bc - ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA2bc aph(2'') NF000076.3 APH(2'')-Ie/IVa family aminoglycoside O-phosphotransferase arr NF000066.1 NAD(+)--rifampin ADP-ribosyltransferase arr NF000318.1 NAD(+)--rifampin ADP-ribosyltransferase blaI - beta-lactamase repressor blaADC - ADC-like cephalosporin-hydrolyzing class C beta-lactamase blaCTX-M - CTX-M-151 family class A beta-lactamase blaLRA10 - LRA10 family class C beta-lactamase blaLRA - LRA12 family subclass B3 metallo-beta-lactamase blaLRA18 - LRA18 family class C beta-lactamase blaLRA - LRA2 family subclass B3 metallo-beta-lactamase blaLRA - LRA3 family subclass B3 metallo-beta-lactamase blaOXA NF000386.2 OXA-10 family class D beta-lactamase blaOXA NF033818.0 OXA-114 family class D beta-lactamase blaOXA NF033702.0 OXA-12 family class D beta-lactamase blaOXA NF000436.2 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000464.2 OXA-143 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000461.2 OXA-184 family class D beta-lactamase blaOXA NF000388.2 OXA-1 family class D beta-lactamase blaOXA NF000417.2 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000269.2 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000418.2 OXA-214 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000501.2 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF033509.1 OXA-22 family class D beta-lactamase blaOXA NF000266.2 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000434.2 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF033653.1 OXA-266 family class D beta-lactamase blaOXA NF033648.1 OXA-274 family class D beta-lactamase blaOXA NF000520.2 OXA-286 family class D beta-lactamase blaOXA NF038386.1 OXA-294 family class D beta-lactamase blaOXA NF000267.2 OXA-2 family class D beta-lactamase blaOXA NF033815.0 OXA-364 family class D beta-lactamase blaOXA NF000415.2 OXA-372 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF038217.1 OXA-427 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF033104.0 OXA-46 family oxacillin-hydrolyzing class D beta-lactamase blaOXA NF000387.2 OXA-48 family class D beta-lactamase blaOXA NF000462.2 OXA-493 family class D beta-lactamase blaOXA NF000432.2 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase blaOXA NF000268.2 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase blaOXA - OXA-542 family carbapenem-hydrolyzing class D beta-lactamase blaOXA - OXA-548 family class D beta-lactamase blaOXA NF033667.1 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF033613.1 OXA-576 family class D beta-lactamase blaOXA NF000500.2 OXA-58 family carbapenem-hydrolyzing class D beta-lactamase blaOXA - OXA-5 family class D beta-lactamase blaOXA NF000395.3 OXA-60 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000435.2 OXA-61 family class D beta-lactamase blaOXA NF000430.2 OXA-62 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF000429.2 OXA-63 family oxacillin-hydrolyzing class D beta-lactamase blaOXA NF038333.1 blaOXA-679 family carbapenem-hydrolyzing class D beta-lactamase blaOXA NF033666.1 OXA-727 family class D beta-lactamase blaOXA NF000502.2 OXA-85 family oxacillin-hydrolyzing class D beta-lactamase blaOXA NF038183.1 OXA-919 family class D beta-lactamase blaOXA NF000463.2 class D beta-lactamase catB8 - type B-3 chloramphenicol O-acetyltransferase CatB8j catB8k - type B-3 chloramphenicol O-acetyltransferase CatB8k copA - copper-translocating P-type ATPase CopA copB - copper/silver-translocating P-type ATPase CopB fos NF000124.1 FosG/FosC2 family fosfomycin resistance glutathione transferase fosB NF000063.1 FosB family fosfomycin resistance bacillithiol transferase fosB NF000098.1 FosB family fosfomycin resistance bacillithiol transferase fos NF033405.1 fosfomycin resistance glutathione transferase FosLL mtrA - efflux transporter MtrCDE transcriptional activator MtrA sat2e - streptothricin N-acetyltransferase Sat2e satA - streptothricin N-acetyltransferase SatA satA - streptothricin N-acetyltransferase SatA vanAo2 NF000092.1 D-alanine--(R)-lactate ligase VanA-Ao2 vanT NF033131.1 VanT-G-like membrane-bound serine racemase vanXY NF000149.1 D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-G vanY NF000086.1 VanY-like protein Family changes - TonB-dependent siderophore receptor gene_symbol: sidero -> - - DNA-binding response regulator gene_symbol: response_reg -> - - SPATE family serine protease autotransporter gene_symbol: spate -> - blaCRP CRP family carbapenem-hydrolyzing class A beta-lactamase hmm_id: - -> NF040548.1 blaLAQ LAQ family class C beta-lactamase hmm_id: - -> NF040478.1 blaSFC SFC family carbapenem-hydrolyzing class A beta-lactamase hmm_id: - -> NF040547.1 dfrE trimethoprim-resistant dihydrofolate reductase DfrE hmm_id: NF033473.1 -> NF040541.1 dfr DfrD/DfrG/DfrK family trimethoprim-resistant dihydrofolate reductase gene_symbol: dfr_DGK -> dfr eat(A) ABC-F type ribosomal protection-like protein Eat(A) family_name: ABC-F type ribosomal protection protein Eat(A) -> ABC-F type ribosomal protection-like protein Eat(A) - macrolide glycosyltransferase gene_symbol: macro_glyco -> - mph Mph(E)/Mph(G) family macrolide 2'-phosphotransferase gene_symbol: mph_3 -> mph nim NimABCDEF family nitroimidazole resistance protein gene_symbol: nimABCDEF -> nim - 16S rRNA (adenine(1408)-N(1))-methyltransferase gene_symbol: npmA_gen -> - qac QacCGHJ group quaternary ammonium compound efflux SMR transporter gene_symbol: qacCGHJ -> qac rgt Rgt1438 family rifamycin-inactivating glycosyltransferase family_name: rifamycin-inactivating glycosyltransferase Rgt -> Rgt1438 family rifamycin-inactivating glycosyltransferase - bleomycin binding protein gene_symbol: sequest -> - - glycosylating toxin gene_symbol: tcd_gen -> - tet tetracycline efflux MFS transporter gene_symbol: tet_MFS_efflux -> tet tet tetracycline resistance ribosomal protection protein gene_symbol: tet_rib_protect -> tet ---------------------------------------------------------------------- Changes included in 2021-08-11.1 ---------------------------------------------------------------------- Overview: - Refinement of resistance information for many alleles in Product name and Subclass fields, particularly in blaSHV and tet families - Several new HMMs for smaller beta-lactamase families - Many new beta-lactamase alleles - Duplications in pubmed references were removed and new references added - New Listeria metal resistance genes were added - Point mutations in Neisseria and Pseudomonas aeruginosa were added - blaACC-5 was removed becuase the only example we have is incomplete - Some family IDs were changed, some nodes in the hierarchy without effect were removed, and some nodes were added - Note that these changes were made to standardize family ID, and improve the organization of families. The removed "families" should not cause the loss of any AMRFinderPlus hits, indeed, the new HMMs could identify some more distant homologs for those families that received them. Summary: Total proteins: 6854 Core proteins: 5880 Plus proteins: 974 AMR proteins: 5923 STRESS proteins: 231 VIRULENCE proteins: 700 Point mutations: 852 Point mutation references: 143 Point mutation organism groups: Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 639 Updates since release 2021-06-01.1: Proteins added: 73 Core proteins added: 52 Plus proteins added: 21 AMR proteins added: 53 STRESS proteins added: 20 Alleles added: 51 Point mutations added: 107 Proteins removed: 1 Core proteins removed: 1 Plus proteins removed: 0 Reference Gene Catalog entries changed: 471 Families added: 22 Families removed: 7 Families changed: 7 Added proteins core AMR AMR bcrA NG_076629.1 WP_002389535.1 bacitracin resistance ABC transporter ATP-binding subunit BcrA blaACT-90 NG_076632.1 WP_023305291.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-90 blaASU1-1 NG_076656.1 WP_219860711.1 class A beta-lactamase ASU1-1 blaB3SU1-1 NG_076657.1 WP_219860712.1 subclass B3 metallo-beta-lactamase B3SU1-1 blaB3SU2-1 NG_076658.1 WP_219860713.1 subclass B3 metallo-beta-lactamase B3SU2-1 blaCMY-172 NG_076652.1 WP_215824899.1 class C beta-lactamase CMY-172 blaGES-49 NG_076643.1 WP_219860707.1 carbapenem-hydrolyzing class A beta-lactamase GES-49 blaIMP-86 NG_076650.1 WP_219860708.1 subclass B1 metallo-beta-lactamase IMP-86 blaIMP-87 NG_076651.1 WP_219860709.1 subclass B1 metallo-beta-lactamase IMP-87 blaIMP-91 NG_076634.1 WP_079387329.1 subclass B1 metallo-beta-lactamase IMP-91 blaKPC-90 NG_076666.1 WP_219833567.1 carbapenem-hydrolyzing class A beta-lactamase KPC-90 blaKPC-91 NG_076667.1 WP_219860720.1 carbapenem-hydrolyzing class A beta-lactamase KPC-91 blaKPC-94 NG_076680.1 WP_219804981.1 class A beta-lactamase KPC-94 blaKPC-95 NG_076681.1 WP_219795346.1 class A beta-lactamase KPC-95 blaLAQ-1 NG_076677.1 WP_219860729.1 class C beta-lactamase LAQ-1 blaNDM-34 NG_076661.1 WP_219860715.1 subclass B1 metallo-beta-lactamase NDM-34 blaNDM-35 NG_076662.1 WP_219860716.1 subclass B1 metallo-beta-lactamase NDM-35 blaNDM-36 NG_076641.1 WP_214140123.1 subclass B1 metallo-beta-lactamase NDM-36 blaNDM-37 NG_076642.1 WP_214251060.1 subclass B1 metallo-beta-lactamase NDM-37 blaNDM-38 NG_076664.1 WP_219860718.1 subclass B1 metallo-beta-lactamase NDM-38 blaOXA-1013 NG_076673.1 WP_219860726.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1013 blaOXA-1014 NG_076674.1 WP_049291121.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1014 blaOXA-1015 NG_076675.1 WP_219860727.1 OXA-10 family class D beta-lactamase OXA-1015 blaOXA-1016 NG_076676.1 WP_219860728.1 OXA-372 family carbapenem-hydrolyzing class D beta-lactamase OXA-1016 blaOXA-1017 NG_076678.1 WP_219860730.1 OXA-2 family class D beta-lactamase OXA-1017 blaOXA-957 NG_076659.1 WP_219860714.1 class D beta-lactamase OXA-957 blaPAD-1 NG_076644.1 WP_068885073.1 carbapenem-hydrolyzing class A beta-lactamase PAD-1 blaPAM-1 NG_076630.1 WP_043245728.1 subclass B3 metallo-beta-lactamase PAM-1 blaPDC-484 NG_076668.1 WP_219860721.1 class C beta-lactamase PDC-484 blaPDC-485 NG_076669.1 WP_219860722.1 class C beta-lactamase PDC-485 blaPDC-486 NG_076670.1 WP_219860723.1 class C beta-lactamase PDC-486 blaPDC-487 NG_076671.1 WP_219860724.1 class C beta-lactamase PDC-487 blaPDC-488 NG_076672.1 WP_219860725.1 class C beta-lactamase PDC-488 blaPLA-4 NG_076631.1 WP_032687534.1 class A beta-lactamase PLA-4 blaPLA-5 NG_076637.1 WP_219860706.1 class A beta-lactamase PLA-5 blaSFDC-1 NG_076654.1 WP_218519361.1 class C beta-lactamase SFDC-1 blaTEM-239 NG_076645.1 WP_197098296.1 class A beta-lactamase TEM-239 blaTEM-244 NG_076655.1 WP_219860710.1 class A beta-lactamase TEM-244 blaVAM-1 NG_076653.1 WP_181726415.1 subclass B1 metallo-beta-lactamase VAM-1 blaVEB-29 NG_076663.1 WP_219860717.1 class A extended-spectrum beta-lactamase VEB-29 blaVEB-30 NG_076665.1 WP_219860719.1 class A extended-spectrum beta-lactamase VEB-30 mcr-10.2 NG_076640.1 WP_208557566.1 phosphoethanolamine--lipid A transferase MCR-10.2 mcr-10.3 NG_076639.1 WP_208584627.1 phosphoethanolamine--lipid A transferase MCR-10.3 mcr-10.4 NG_076638.1 WP_208595319.1 phosphoethanolamine--lipid A transferase MCR-10.4 mcr-2.8 NG_076679.1 WP_219860731.1 phosphoethanolamine--lipid A transferase MCR-2.8 poxtA2 NG_076660.1 WP_209691075.1 ABC-F type ribosomal protection protein PoxtA2 tmexC2 NG_076647.1 WP_088903431.1 multidrug efflux RND transporter periplasmic adaptor subunit TMexC2 tmexC3 NG_076635.1 WP_034039546.1 multidrug efflux RND transporter periplasmic adaptor subunit TMexC3 tmexD2 NG_076648.1 WP_027591160.1 multidrug efflux RND transporter permease subunit TMexD2 tmexD3 NG_076636.1 WP_034065037.1 multidrug efflux RND transporter permease subunit TMexD3 toprJ2 NG_076649.1 WP_088903432.1 multidrug efflux transporter outer membrane subunit TOprJ2 core STRESS BIOCIDE qacH NG_076646.1 WP_000121134.1 quaternary ammonium compound efflux SMR transporter QacH plus AMR AMR aph(3')-IId MT975442.1 QQK39289.1 aminoglycoside O-phosphotransferase APH(3')-IId mcr-9.2 JAGFWX010000027.1 MBO4175406.1 phosphoethanolamine--lipid A transferase MCR-9.2 plus STRESS METAL cadC L28104.1 AAA25276.1 Cd(II)-sensing metalloregulatory transcriptional repressor CadC cadC AP022822.1 BCA86950.1 Cd(II)-sensing metalloregulatory transcriptional repressor CadC cadA AP022822.1 BCA86951.1 cadmium-translocating P-type ATPase CadA arsD2 CM001159.1 EGJ25779.1 arsenite efflux transporter metallochaperone ArsD-related protein arsA CM001159.1 EGJ25780.1 arsenite efflux transporter ATPase subunit ArsA arsR CM001159.1 EGJ25781.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR arsD CM001159.1 EGJ25782.1 arsenite efflux transporter metallochaperone ArsD arsR CM001159.1 EGJ25783.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR arsA CM001159.1 EGJ25784.1 arsenite efflux transporter ATPase subunit ArsA arsB CM001159.1 EGJ25785.1 arsenite efflux transporter membrane subunit ArsB arsB CM001159.1 EGJ25786.1 arsenite efflux transporter membrane subunit ArsB cadC CM001159.1 EGJ25791.1 Cd(II)-sensing metalloregulatory transcriptional repressor CadC cadA CM001159.1 EGJ25792.1 cadmium-translocating P-type ATPase CadA arsB ABAGVN010000004.1 EHL9033999.1 arsenite efflux transporter membrane subunit ArsB arsB QDBI01000003.1 KAA9473339.1 arsenite efflux transporter membrane subunit ArsB arsD QDBI01000003.1 KAA9473340.1 arsenite efflux transporter metallochaperone ArsD arsA QDBI01000003.1 KAA9473341.1 arsenite efflux transporter ATPase subunit ArsA arsD QDBI01000003.1 KAA9473342.1 arsenite efflux transporter metallochaperone ArsD arsR QDBI01000003.1 KAA9473343.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR Added point mutations core AMR POINT 16S_C1191T SPECTINOMYCIN Neisseria 23S_A2045G AZITHROMYCIN Neisseria 23S_A2057G AZITHROMYCIN Neisseria 23S_A2145G AZITHROMYCIN Neisseria 23S_C2597T AZITHROMYCIN Neisseria ampD_H77Y CEPHALOSPORIN Pseudomonas_aeruginosa ampD_T139M CEPHALOSPORIN Pseudomonas_aeruginosa ampR_D135G CEPHALOSPORIN Pseudomonas_aeruginosa ampR_G154R CEPHALOSPORIN Pseudomonas_aeruginosa dacB_G437D CEPHALOSPORIN Pseudomonas_aeruginosa dacB_T428P CEPHALOSPORIN Pseudomonas_aeruginosa dacB_W459STOP CEPHALOSPORIN Pseudomonas_aeruginosa folP_R228S SULFONAMIDE Neisseria glpT_T211P FOSFOMYCIN Pseudomonas_aeruginosa gyrA_D87G QUINOLONE Pseudomonas_aeruginosa gyrA_D87H QUINOLONE Pseudomonas_aeruginosa gyrA_D87N QUINOLONE Pseudomonas_aeruginosa gyrA_D95A QUINOLONE Neisseria gyrA_D95G QUINOLONE Neisseria gyrA_D95N QUINOLONE Neisseria gyrA_H80R QUINOLONE Pseudomonas_aeruginosa gyrA_S91F QUINOLONE Neisseria gyrA_T83I QUINOLONE Pseudomonas_aeruginosa gyrB_D429N ZOLIFLODACIN Neisseria gyrB_K450N ZOLIFLODACIN Neisseria gyrB_K450T ZOLIFLODACIN Neisseria macAB_G-48T AZITHROMYCIN Neisseria mexB_V45L BETA-LACTAM/QUINOLONE/TETRACYCLINE Pseudomonas_aeruginosa mexD_Q178R AVIBACTAM Pseudomonas_aeruginosa mexD_S133G AVIBACTAM Pseudomonas_aeruginosa mexZ_G195E CEPHALOSPORIN Pseudomonas_aeruginosa mtrC_C-120T AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria mtrR_A-53del AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria mtrR_A-56C BETA-LACTAM/TETRACYCLINE Neisseria mtrR_A39T AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria mtrR_G-131A AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria mtrR_G45D AZITHROMYCIN/CEPHALOSPORIN/TETRACYCLINE Neisseria norM_A-7G QUINOLONE Neisseria norM_C-104T QUINOLONE Neisseria ompK35_E132K CARBAPENEM Klebsiella ompK35_W230STOP CARBAPENEM Klebsiella ompK36_D135DGD CARBAPENEM Klebsiella ompK36_E78STOP CARBAPENEM Klebsiella ompK36_T126STOP CARBAPENEM Klebsiella ompK36_T136TDT CARBAPENEM Klebsiella ompK36_T192del CARBAPENEM Klebsiella ompK36_T261STOP CARBAPENEM Klebsiella ompK36_T333N CARBAPENEM Klebsiella ompK36_W125STOP CARBAPENEM Klebsiella oprD_Q142STOP CARBAPENEM Pseudomonas_aeruginosa oprD_W138STOP CARBAPENEM Pseudomonas_aeruginosa parC_D86N QUINOLONE Neisseria parC_E91G QUINOLONE Neisseria parC_E91K QUINOLONE Neisseria parC_S87I QUINOLONE Neisseria parC_S87L QUINOLONE Pseudomonas_aeruginosa parC_S87N QUINOLONE Neisseria parC_S87R QUINOLONE Neisseria parC_S88P QUINOLONE Neisseria parE_A473V QUINOLONE Pseudomonas_aeruginosa parE_G410V QUINOLONE Neisseria parE_M437I QUINOLONE Pseudomonas_aeruginosa penA_A311V CEPHALOSPORIN Neisseria penA_A501AA CEPHALOSPORIN Neisseria penA_A501P CEPHALOSPORIN Neisseria penA_A501T BETA-LACTAM Neisseria penA_A501V CEPHALOSPORIN Neisseria penA_A510V CEPHALOSPORIN Neisseria penA_A516G CEPHALOSPORIN Neisseria penA_D346DD BETA-LACTAM Neisseria penA_F504L CEPHALOSPORIN Neisseria penA_G542S CEPHALOSPORIN Neisseria penA_G545S CEPHALOSPORIN Neisseria penA_I312M CEPHALOSPORIN Neisseria penA_N512Y CEPHALOSPORIN Neisseria penA_P551L BETA-LACTAM Neisseria penA_P551S BETA-LACTAM Neisseria penA_T483S CEPHALOSPORIN Neisseria penA_V316P CEPHALOSPORIN Neisseria penA_V316T CEPHALOSPORIN Neisseria phoP_A110V COLISTIN Pseudomonas_aeruginosa phoP_R117L COLISTIN Pseudomonas_aeruginosa phoQ_K123Q COLISTIN Pseudomonas_aeruginosa phoQ_V260G COLISTIN Pseudomonas_aeruginosa ponA_L421P BETA-LACTAM Neisseria porB1b_A121D BETA-LACTAM Neisseria porB1b_A121H BETA-LACTAM Neisseria porB1b_A121N BETA-LACTAM Neisseria porB1b_A121P BETA-LACTAM Neisseria porB1b_G120D BETA-LACTAM Neisseria porB1b_G120K BETA-LACTAM Neisseria porB1b_G120P BETA-LACTAM Neisseria porB1b_G120R BETA-LACTAM Neisseria rplD_G70D AZITHROMYCIN Neisseria rplV_K83KKGPSLK AZITHROMYCIN Neisseria rplV_K90KARAK AZITHROMYCIN Neisseria rpoB_G158V CEPHALOSPORIN Neisseria rpoB_P157L CEPHALOSPORIN Neisseria rpoB_R201H CEPHALOSPORIN Neisseria rpoD_DDDA92del CEPHALOSPORIN Neisseria rpoD_E98K CEPHALOSPORIN Neisseria rpsE_K28E SPECTINOMYCIN Neisseria rpsE_T24P SPECTINOMYCIN Neisseria rpsE_V27del SPECTINOMYCIN Neisseria rpsJ_V57L TETRACYCLINE Neisseria rpsJ_V57M TETRACYCLINE Neisseria rpsJ_V57Q TETRACYCLINE Neisseria Removed proteins core AMR AMR blaACC-5 NG_048595.1 WP_063857715.1 cephalosporin-hydrolyzing class C beta-lactamase ACC-5 Changed reference gene catalog records lin WP_010989615.1 product_name: lincomycin resistance ABC-F type ribosomal protection protein -> lmo0919 family lincomycin resistance ABC-F type ribosomal protection protein tet(X3) WP_015060917.1 subclass: TETRACYCLINE -> TIGECYCLINE tet(X3) WP_024160783.1 subclass: TETRACYCLINE -> TIGECYCLINE tet(X5) WP_063856444.1 subclass: TETRACYCLINE -> TIGECYCLINE tet(X4) WP_094309310.1 subclass: TETRACYCLINE -> TIGECYCLINE tet(X5) WP_150378267.1 subclass: TETRACYCLINE -> TIGECYCLINE blaACC-2 WP_063857702.1 pubmed_reference: 10817695,10817695 -> 10817695 blaACT-1 WP_063857727.1 pubmed_reference: 9055993,9055993 -> 9055993 blaACT-10 WP_063857730.1 pubmed_reference: 25312010,25312010 -> 25312010 blaACT-23 WP_045620946.1 pubmed_reference: 24629772,24629772 -> 24629772 blaACT-3 WP_063857773.1 pubmed_reference: 18789849,18789849 -> 18789849 blaACT-9 WP_013981172.1 pubmed_reference: 21690276,21690276 -> 21690276 blaBEL-1 WP_063857830.1 pubmed_reference: 16127048,16127048 -> 16127048 blaBEL-2 WP_063857831.1 pubmed_reference: 19884378,19884378 -> 19884378 blaBEL-3 WP_063857832.1 pubmed_reference: 19933793,19933793 -> 19933793 blaBKC-1 WP_063857834.1 pubmed_reference: 26055384 -> 26055384, 34154411 blaCARB-1 WP_063857835.1 pubmed_reference: 377324, 11959558,11959558 -> 11959558, 377324 blaCARB-10 WP_063857836.1 pubmed_reference: 19380596,19380596 -> 19380596 blaCARB-14 WP_063857843.1 pubmed_reference: 22633451,22633451 -> 22633451 blaCARB-4 WP_032489168.1 pubmed_reference: 3087285, 9687391,9687391 -> 3087285, 9687391 blaCARB-5 WP_063859341.1 pubmed_reference: 2786828, 10722515,10722515 -> 10722515, 2786828 blaCARB-6 WP_063859348.1 pubmed_reference: 9925522,9925522 -> 9925522 blaCARB-7 WP_029628776.1 pubmed_reference: 12069969,12069969 -> 12069969 blaCARB-8 WP_063859363.1 pubmed_reference: 12709319,12709319 -> 12709319 blaCARB-9 WP_002022164.1 pubmed_reference: 15388476,15388476 -> 15388476 blaCFE-1 WP_032490699.1 pubmed_reference: 15047515,15047515 -> 15047515 blaCMY-1 WP_032488864.1 pubmed_reference: 8843306,8843306 -> 8843306 blaCMY-10 WP_032492452.1 pubmed_reference: 12969288,12969288 -> 12969288 blaCMY-108 WP_063859673.1 pubmed_reference: 24500191,24500191 -> 24500191 blaCMY-11 WP_032492458.1 pubmed_reference: 11815567,11815567 -> 11815567 blaCMY-110 WP_063859688.1 pubmed_reference: 24709044,24709044 -> 24709044 blaCMY-12 WP_063859743.1 pubmed_reference: 12407124,12407124 -> 12407124 blaCMY-13 WP_020996270.1 pubmed_reference: 15273143,15273143 -> 15273143 blaCMY-14 WP_063859816.1 pubmed_reference: 15504832,15504832 -> 15504832 blaCMY-15 WP_063859817.1 pubmed_reference: 15504832,15504832 -> 15504832 blaCMY-16 WP_014386387.1 pubmed_reference: 16436718,16436718 -> 16436718 blaCMY-18 WP_063859824.1 pubmed_reference: 16584308,16584308 -> 16584308 blaCMY-19 WP_063859826.1 pubmed_reference: 16436707,16436707 -> 16436707 blaCMY-2 WP_000976514.1 pubmed_reference: 8787910,8787910 -> 8787910 blaCMY-20 WP_063859827.1 pubmed_reference: 18207348,18207348 -> 18207348 blaCMY-21 WP_063859828.1 pubmed_reference: 16716570,16716570 -> 16716570 blaCMY-23 WP_000976515.1 pubmed_reference: 17110393,17110393 -> 17110393 blaCMY-24 WP_032491928.1 pubmed_reference: 17587551,17587551 -> 17587551 blaCMY-25 WP_003830525.1 pubmed_reference: 19523051,19523051 -> 19523051 blaCMY-26 WP_063859830.1 pubmed_reference: 17720829,17720829 -> 17720829 blaCMY-27 WP_063859831.1 pubmed_reference: 19523051,19523051 -> 19523051 blaCMY-29 WP_063859833.1 pubmed_reference: 19414570,19414570 -> 19414570 blaCMY-30 WP_000976513.1 pubmed_reference: 19414570,19414570 -> 19414570 blaCMY-31 WP_012262157.1 pubmed_reference: 18065410,18065410 -> 18065410 blaCMY-36 WP_012262164.1 pubmed_reference: 19104021,19104021 -> 19104021 blaCMY-37 WP_063859838.1 pubmed_reference: 18619820,18619820 -> 18619820 blaCMY-38 WP_063553425.1 pubmed_reference: 18458126,18458126 -> 18458126 blaCMY-4 WP_015056382.1 pubmed_reference: 9868767,9868767 -> 9868767 blaCMY-40 WP_063859840.1 pubmed_reference: 19523051,19523051 -> 19523051 blaCMY-41 WP_048241752.1 pubmed_reference: 19343954,19343954 -> 19343954 blaCMY-42 WP_039023136.1 pubmed_reference: 21388298,21388298 -> 21388298 blaCMY-45 WP_063859843.1 pubmed_reference: 21402851,21402851 -> 21402851 blaCMY-5 WP_015059331.1 pubmed_reference: 10348751,10348751 -> 10348751 blaCMY-55 WP_063859849.1 pubmed_reference: 22956023,22956023 -> 22956023 blaCMY-56 WP_063859850.1 pubmed_reference: 22956023,22956023 -> 22956023 blaCMY-57 WP_063859851.1 pubmed_reference: 22956023,22956023 -> 22956023 blaCMY-7 WP_032490765.1 pubmed_reference: 12039894,12039894 -> 12039894 blaCMY-8 WP_012477380.1 pubmed_reference: 10817689,10817689 -> 10817689 blaCMY-9 WP_032490177.1 pubmed_reference: 12121914,12121914 -> 12121914 blaCMY-99 WP_063859919.1 pubmed_reference: 24165184,24165184 -> 24165184 blaCTX-M-1 WP_013188473.1 pubmed_reference: 8834913,8834913 -> 8834913 blaCTX-M-10 WP_032491157.1 pubmed_reference: 11158766,11158766 -> 11158766 blaCTX-M-100 WP_032494234.1 pubmed_reference: 23050014,23050014 -> 23050014 blaCTX-M-116 WP_032495225.1 pubmed_reference: 23318795,23318795 -> 23318795 blaCTX-M-117 WP_032495259.1 pubmed_reference: 23127481,23127481 -> 23127481 blaCTX-M-12 WP_032491777.1 pubmed_reference: 11408239,11408239 -> 11408239 blaCTX-M-123 WP_031942271.1 pubmed_reference: 23752509,23752509 -> 23752509 blaCTX-M-124 WP_063859945.1 pubmed_reference: 22330908,22314536 -> 22314536, 22330908 blaCTX-M-13 WP_032489927.1 pubmed_reference: 11850241,11850241 -> 11850241 blaCTX-M-14 WP_001617865.1 pubmed_reference: 11850241,11850241 -> 11850241 blaCTX-M-16 WP_063859967.1 pubmed_reference: 11451684,11451684 -> 11451684 blaCTX-M-17 WP_011117618.1 pubmed_reference: 11959547,11959547 -> 11959547 blaCTX-M-19 WP_063860037.1 pubmed_reference: 11709308,11709308 -> 11709308 blaCTX-M-2 WP_025368620.1 pubmed_reference: 8834913,8834913 -> 8834913 blaCTX-M-20 WP_063860038.1 pubmed_reference: 12007800,12007800 -> 12007800 blaCTX-M-21 WP_063860039.1 pubmed_reference: 12007800,12007800 -> 12007800 blaCTX-M-22 WP_032491377.1 pubmed_reference: 16533535,16533535 -> 16533535 blaCTX-M-23 WP_063860040.1 pubmed_reference: 15201232,15201232 -> 15201232 blaCTX-M-24 WP_012579082.1 pubmed_reference: 16291869,16291869 -> 16291869 blaCTX-M-25 WP_022542384.1 pubmed_reference: 15561863,15561863 -> 15561863 blaCTX-M-26 WP_063860041.1 pubmed_reference: 12493817,15561863 -> 12493817, 15561863 blaCTX-M-27 WP_032277257.1 pubmed_reference: 12775683,12775683 -> 12775683 blaCTX-M-28 WP_063860042.1 pubmed_reference: 15941775,15941775 -> 15941775 blaCTX-M-29 WP_063860043.1 pubmed_reference: 16533535,16533535 -> 16533535 blaCTX-M-3 WP_011091028.1 pubmed_reference: 9559791,9559791 -> 9559791 blaCTX-M-30 WP_032490752.1 pubmed_reference: 15504875,15504875 -> 15504875 blaCTX-M-31 WP_063860044.1 pubmed_reference: 12936986,12936986 -> 12936986 blaCTX-M-32 WP_000239591.1 pubmed_reference: 15155242,15155242 -> 15155242 blaCTX-M-33 WP_032490682.1 pubmed_reference: 17234386,17234386 -> 17234386 blaCTX-M-34 WP_063860045.1 pubmed_reference: 16244084,16244084 -> 16244084 blaCTX-M-37 WP_063860048.1 pubmed_reference: 16949257,16949257 -> 16949257 blaCTX-M-39 WP_044702041.1 pubmed_reference: 16251320,16251320 -> 16251320 blaCTX-M-4 WP_032489025.1 pubmed_reference: 9593162,9593162 -> 9593162 blaCTX-M-40 WP_063860050.1 pubmed_reference: 16697557,16697557 -> 16697557 blaCTX-M-41 WP_063860051.1 pubmed_reference: 18487232,18487232 -> 18487232 blaCTX-M-42 WP_063860052.1 pubmed_reference: 18212109,18212109 -> 18212109 blaCTX-M-43 WP_063860053.1 pubmed_reference: 16510850,16510850 -> 16510850 blaCTX-M-44 WP_063860054.1 pubmed_reference: 8619581,21078949 -> 21078949, 8619581 blaCTX-M-46 WP_063860055.1 pubmed_reference: 16082008,16082008 -> 16082008 blaCTX-M-47 WP_063860056.1 pubmed_reference: 16082008,16082008 -> 16082008 blaCTX-M-48 WP_063860057.1 pubmed_reference: 16082008,16082008 -> 16082008 blaCTX-M-49 WP_063860058.1 pubmed_reference: 16082008,16082008 -> 16082008 blaCTX-M-5 WP_032072602.1 pubmed_reference: 9687393,9687393 -> 9687393 blaCTX-M-50 WP_063860059.1 pubmed_reference: 16082008,16082008 -> 16082008 blaCTX-M-53 WP_012579062.1 pubmed_reference: 19273683,19273683 -> 19273683 blaCTX-M-54 WP_063860062.1 pubmed_reference: 16785225,16785225 -> 16785225 blaCTX-M-55 WP_015387340.1 pubmed_reference: 17449211,17449211 -> 17449211 blaCTX-M-56 WP_063860063.1 pubmed_reference: 17548490,17548490 -> 17548490 blaCTX-M-59 WP_063860065.1 pubmed_reference: 18347108,18347108 -> 18347108 blaCTX-M-6 WP_032489170.1 pubmed_reference: 9742701,9742701 -> 9742701 blaCTX-M-61 WP_063860067.1 pubmed_reference: 17804424,17804424 -> 17804424 blaCTX-M-62 WP_032493168.1 pubmed_reference: 18725449,18725449 -> 18725449 blaCTX-M-64 WP_032492042.1 pubmed_reference: 18955524,18955524 -> 18955524 blaCTX-M-65 WP_013188475.1 pubmed_reference: 18195064,18195064 -> 18195064 blaCTX-M-66 WP_032491954.1 pubmed_reference: 17913434,17913434 -> 17913434 blaCTX-M-67 WP_032492044.1 pubmed_reference: 18775649,18775649 -> 18775649 blaCTX-M-68 WP_063860069.1 pubmed_reference: 19748232,19748232 -> 19748232 blaCTX-M-69 WP_063860070.1 pubmed_reference: 21940649,21940649 -> 21940649 blaCTX-M-7 WP_032489171.1 pubmed_reference: 9742701,9742701 -> 9742701 blaCTX-M-71 WP_032492553.1 pubmed_reference: 19620330,19620330 -> 19620330 blaCTX-M-72 WP_032491264.1 pubmed_reference: 19590148,19590148 -> 19590148 blaCTX-M-74 WP_063860073.1 pubmed_reference: 19748435,19748435 -> 19748435 blaCTX-M-75 WP_063860074.1 pubmed_reference: 19748435,19748435 -> 19748435 blaCTX-M-78 WP_063860077.1 pubmed_reference: 20421403,20421403 -> 20421403 blaCTX-M-79 WP_063860078.1 pubmed_reference: 18772941,18772941 -> 18772941 blaCTX-M-8 WP_032489598.1 pubmed_reference: 10858358,10858358 -> 10858358 blaCTX-M-82 WP_063860081.1 pubmed_reference: 19297379,19297379 -> 19297379 blaCTX-M-83 WP_063860082.1 pubmed_reference: 18984647,18984647 -> 18984647 blaCTX-M-84 WP_063860083.1 pubmed_reference: 18984647,18984647 -> 18984647 blaCTX-M-85 WP_063860084.1 pubmed_reference: 18984647,18984647 -> 18984647 blaCTX-M-86 WP_063860085.1 pubmed_reference: 18984647,18984647 -> 18984647 blaCTX-M-87 WP_032492184.1 pubmed_reference: 19429759,19429759 -> 19429759 blaCTX-M-89 WP_063860087.1 pubmed_reference: 19587301,19587301 -> 19587301 blaCTX-M-9 WP_032489926.1 pubmed_reference: 10858363,11850241 -> 10858363, 11850241 blaCTX-M-93 WP_032495023.1 pubmed_reference: 21343457,21343457 -> 21343457 blaCTX-M-94 WP_063860091.1 pubmed_reference: 23050014,23050014 -> 23050014 blaDHA-1 WP_004236386.1 pubmed_reference: 9736562,9736562 -> 9736562 blaDHA-2 WP_063860103.1 pubmed_reference: 11157909,11157909 -> 11157909 blaDHA-3 WP_032490957.1 pubmed_reference: 16216104,16216104 -> 16216104 blaFOX-1 WP_063860494.1 pubmed_reference: 7811034,7811034 -> 7811034 blaFOX-2 WP_032489067.1 pubmed_reference: 9303413,9303413 -> 9303413 blaFOX-3 WP_033147149.1 pubmed_reference: 9527810,9527810 -> 9527810 blaFOX-4 WP_032489727.1 pubmed_reference: 10952615,10952615 -> 10952615, 31685471 blaFOX-5 WP_016809943.1 pubmed_reference: 11600376,11600376 -> 11600376 blaFOX-7 WP_032072107.1 pubmed_reference: 24088849,24088849 -> 24088849 blaFOX-8 WP_032495011.1 pubmed_reference: 22956023,22956023 -> 22956023 blaGES-1 WP_013250881.1 pubmed_reference: 10681329,10681329 -> 10681329 blaGES-11 WP_001211000.1 pubmed_reference: 19451292,19451292 -> 19451292 blaGES-12 WP_063860500.1 pubmed_reference: 20805394,20805394 -> 20805394 blaGES-13 WP_063860501.1 pubmed_reference: 20065056,20065056 -> 20065056 blaGES-14 WP_063860502.1 pubmed_reference: 20805394,20805394 -> 20805394 blaGES-18 WP_063860506.1 pubmed_reference: 23114760,23114760 -> 23114760 blaGES-2 WP_045912044.1 pubmed_reference: 11502535,11502535 -> 11502535 blaGES-3 WP_063860515.1 pubmed_reference: 15155185,15155185 -> 15155185 blaGES-4 WP_063860518.1 pubmed_reference: 15273099,15273099 -> 15273099 blaGES-5 WP_012658785.1 pubmed_reference: 15135524,15135524 -> 15135524 blaGES-6 WP_032490973.1 pubmed_reference: 15135524,15135524 -> 15135524 blaGES-7 WP_032490683.1 pubmed_reference: 10952563,10952563 -> 10952563 blaGES-8 WP_063860519.1 pubmed_reference: 11679551,11679551 -> 11679551 blaGES-9 WP_063860520.1 pubmed_reference: 16048994,16048994 -> 16048994 blaGIM-1 WP_015588753.1 pubmed_reference: 15561840,15561840 -> 15561840 blaIMI-1 WP_053073497.1 pubmed_reference: 8878585,8878585 -> 8878585 blaIMI-3 WP_063860568.1 pubmed_reference: 21192875,21192875 -> 21192875 blaIMP-1 WP_003159548.1 pubmed_reference: 8141584,8141584 -> 8141584 blaIMP-10 WP_032490175.1 pubmed_reference: 12019129,12019129 -> 12019129 blaIMP-12 WP_063860574.1 pubmed_reference: 12709317,12709317 -> 12709317 blaIMP-13 WP_042862936.1 pubmed_reference: 12951335,12951335 -> 12951335 blaIMP-15 WP_063860575.1 pubmed_reference: 18362195,18362195 -> 18362195 blaIMP-16 WP_063860576.1 pubmed_reference: 15561846,15561846 -> 15561846 blaIMP-18 WP_063848609.1 pubmed_reference: 16723605,16723605 -> 16723605 blaIMP-19 WP_032491874.1 pubmed_reference: 17938180,7938180 -> 17938180, 7938180 blaIMP-2 WP_063860578.1 pubmed_reference: 10770756,10770756 -> 10770756 blaIMP-22 WP_063860581.1 pubmed_reference: 19270313,19270313 -> 19270313 blaIMP-24 WP_063860583.1 pubmed_reference: 18804966,18804966 -> 18804966 blaIMP-25 WP_063860584.1 pubmed_reference: 23006757,23006757 -> 23006757 blaIMP-26 WP_060614779.1 pubmed_reference: 20463166,20463166 -> 20463166 blaIMP-28 WP_063860586.1 pubmed_reference: 22668859,22668859 -> 22668859 blaIMP-29 WP_063860587.1 pubmed_reference: 22290960,22290960 -> 22290960 blaIMP-3 WP_063860588.1 pubmed_reference: 10898670,10898670 -> 10898670 blaIMP-30 WP_063860589.1 pubmed_reference: 23836186,23836186 -> 23836186 blaIMP-33 WP_063860591.1 pubmed_reference: 24041889,24041889 -> 24041889 blaIMP-34 WP_032492622.1 pubmed_reference: 23541689,23541689 -> 23541689 blaIMP-35 WP_063860592.1 pubmed_reference: 23341129,23341129 -> 23341129 blaIMP-4 WP_015060105.1 pubmed_reference: 11181348,17284537 -> 11181348, 17284537 blaIMP-43 WP_063860606.1 pubmed_reference: 23836174,23836174 -> 23836174 blaIMP-44 WP_063860607.1 pubmed_reference: 23836174,23836174 -> 23836174 blaIMP-45 WP_063860608.1 pubmed_reference: 24777897,24777897 -> 24777897 blaIMP-5 WP_063860611.1 pubmed_reference: 12393197,12393197 -> 12393197 blaIMP-6 WP_032492096.1 pubmed_reference: 11302793,11302793 -> 11302793 blaIMP-7 WP_063860619.1 pubmed_reference: 11751148,11751148 -> 11751148 blaIMP-8 WP_012695457.1 pubmed_reference: 11451699,11451699 -> 11451699 blaIMP-9 WP_021018609.1 pubmed_reference: 16377710,16377710 -> 16377710 blaIND-1 WP_063860620.1 pubmed_reference: 10077836,10077836 -> 10077836 blaIND-2 WP_034735890.1 pubmed_reference: 11036018,11036018 -> 11036018 blaIND-2a WP_063860625.1 pubmed_reference: 11036018,11036018 -> 11036018 blaIND-3 WP_063860626.1 pubmed_reference: 11036018,11036018 -> 11036018 blaIND-4 WP_063860627.1 pubmed_reference: 11036018,11036018 -> 11036018 blaIND-5 WP_063860628.1 pubmed_reference: 17470648,17470648 -> 17470648 blaIND-6 WP_063860629.1 pubmed_reference: 19651915,19651915 -> 19651915 blaIND-7 WP_063860630.1 pubmed_reference: 20305272,20305272 -> 20305272 blaKPC-10 WP_063860633.1 pubmed_reference: 20038618,20038618 -> 20038618 blaKPC-11 WP_032494844.1 pubmed_reference: 22322349,22322349 -> 22322349 blaKPC-3 WP_004152396.1 pubmed_reference: 15561858,19015357 -> 15561858, 19015357 blaKPC-4 WP_015062847.1 pubmed_reference: 19015357,19015357 -> 19015357 blaKPC-5 WP_015256839.1 pubmed_reference: 19015357,19015357 -> 19015357 blaKPC-53 WP_156649232.1 genbank_cds_start: 8752 -> 64886 genbank_cds_stop: 9639 -> 65773 genbank_nucleotide_accession: WNWP01000038.1 -> CP058327.1 genbank_protein_accession: MUT87649.1 -> QOS10027.1 blaKPC-6 WP_047665864.1 pubmed_reference: 22908150,22908150 -> 22908150 blaKPC-82 WP_202781289.1 product_name: inhibitor-resistant class A beta-lactamase KPC-82 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-82 pubmed_reference: -> 33972237 subclass: CARBAPENEM -> CEPHALOSPORIN blaLAT-1 WP_063860798.1 pubmed_reference: 7811049,7811049 -> 7811049 blaMIR-1 WP_032489464.1 pubmed_reference: 1963529,1963529 -> 1963529 blaMIR-4 WP_032492100.1 pubmed_reference: 18781358,18781358 -> 18781358 blaMOX-1 WP_032489888.1 pubmed_reference: 8112596,8112596 -> 8112596 blaMOX-2 WP_063860845.1 pubmed_reference: 12069985,12069985 -> 12069985 blaNDM-12 WP_063860855.1 pubmed_reference: 25092693,25092693 -> 25092693 blaNDM-13 WP_063860856.1 pubmed_reference: 26169399,26169399 -> 26169399 blaNDM-14 WP_063860857.1 pubmed_reference: 25645836,25645836 -> 25645836 blaNDM-2 WP_063860860.1 pubmed_reference: 21427107,21427107 -> 21427107 blaNDM-3 WP_032492661.1 pubmed_reference: 23330550,23330550 -> 23330550 blaNDM-4 WP_063860861.1 pubmed_reference: 22252797,22252797 -> 22252797 blaNDM-5 WP_023408309.1 pubmed_reference: 21930874,21930874 -> 21930874 blaNDM-7 WP_032495622.1 pubmed_reference: 23557929,23557929 -> 23557929 blaNDM-8 WP_032492624.1 pubmed_reference: 23459485,23459485 -> 23459485 blaNDM-9 WP_032495672.1 pubmed_reference: 24913967,24913967 -> 24913967 blaOXA-11 WP_063860939.1 pubmed_reference: 8215276,8215276 -> 8215276 blaOXA-14 WP_064056056.1 pubmed_reference: 7486940,7486940 -> 7486940 blaOXA-141 WP_058177653.1 pubmed_reference: 19721065,20482453 -> 19721065, 20482453 blaOXA-142 WP_063861041.1 pubmed_reference: 19721065,20482453 -> 19721065, 20482453 blaOXA-145 WP_063861043.1 pubmed_reference: 19721065,21665906 -> 19721065, 21665906 blaOXA-147 WP_063861045.1 pubmed_reference: 20008045,20008045 -> 20008045 blaOXA-15 WP_063861048.1 pubmed_reference: 9087490,9087490 -> 9087490 blaOXA-161 WP_063861101.1 pubmed_reference: 19770278,19770278 -> 19770278 blaOXA-17 WP_032491804.1 pubmed_reference: 10348753,10348753 -> 10348753 blaOXA-19 WP_063861309.1 pubmed_reference: 9835500,9835500 -> 9835500 blaOXA-226 WP_063861826.1 pubmed_reference: 19933793,19933793 -> 19933793 blaOXA-28 WP_032489753.1 pubmed_reference: 11158739,11158739 -> 11158739 blaOXA-295 WP_005260134.1 product_name: class D beta-lactamase OXA-295 -> OXA-294 family class D beta-lactamase OXA-295 blaOXA-297 WP_005227858.1 product_name: class D beta-lactamase OXA-297 -> OXA-294 family class D beta-lactamase OXA-297 blaOXA-298 WP_005282462.1 product_name: class D beta-lactamase OXA-298 -> OXA-294 family class D beta-lactamase OXA-298 blaOXA-32 WP_063862613.1 pubmed_reference: 11796380,11796380 -> 11796380 blaOXA-35 WP_063862720.1 pubmed_reference: 11679562,11679562 -> 11679562 blaOXA-543 WP_058132644.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaOXA-544 WP_071537493.1 subclass: BETA-LACTAM -> CEPHALOSPORIN blaPDC-221 WP_100931731.1 product_name: class C beta-lactamase PDC-221 -> inhibitor-resistant class C beta-lactamase PDC-221 pubmed_reference: -> 29149337 blaPDC-222 WP_100931732.1 product_name: class C beta-lactamase PDC-222 -> inhibitor-resistant class C beta-lactamase PDC-222 pubmed_reference: -> 29149337 blaPDC-223 WP_100931733.1 product_name: class C beta-lactamase PDC-223 -> inhibitor-resistant class C beta-lactamase PDC-223 pubmed_reference: -> 29149337 blaPDC-335 WP_148044427.1 product_name: class C beta-lactamase PDC-335 -> inhibitor-resistant class C beta-lactamase PDC-335 pubmed_reference: -> 30141088 blaPDC-80 WP_058169253.1 product_name: class C beta-lactamase PDC-80 -> inhibitor-resistant class C beta-lactamase PDC-80 pubmed_reference: 26248364 -> 26248364, 30141088 blaPER-1 WP_001100753.1 pubmed_reference: 8141562,8141562 -> 8141562 blaPER-2 WP_032491907.1 pubmed_reference: 8851581,8851581 -> 8851581 blaPER-6 WP_063864595.1 pubmed_reference: 20145085,20145085 -> 20145085 blaPER-7 WP_032495440.1 pubmed_reference: 21383087,21383087 -> 21383087 blaSHV-1 WP_001620095.1 pubmed_reference: 10582889,10582889 -> 10582889 blaSHV-100 WP_063864604.1 product_name: class A beta-lactamase SHV-100 -> class A broad-spectrum beta-lactamase SHV-100 pubmed_reference: 21415202,21415202 -> 21415202 blaSHV-101 WP_063864605.1 product_name: class A beta-lactamase SHV-101 -> class A broad-spectrum beta-lactamase SHV-101 pubmed_reference: 17804424,17804424 -> 17804424 blaSHV-102 WP_063864606.1 pubmed_reference: 18566158,18566158 -> 18566158 blaSHV-103 WP_063864607.1 product_name: class A beta-lactamase SHV-103 -> class A broad-spectrum beta-lactamase SHV-103 pubmed_reference: 18620848,18620848 -> 18620848 blaSHV-104 WP_032492114.1 product_name: class A extended-spectrum beta-lactamase SHV-104 -> class A broad-spectrum beta-lactamase SHV-104 blaSHV-105 WP_063864608.1 pubmed_reference: 19075050,19075050 -> 19075050 blaSHV-108 WP_063864611.1 product_name: class A beta-lactamase SHV-108 -> class A broad-spectrum beta-lactamase SHV-108 blaSHV-109 WP_063864612.1 pubmed_reference: 18725449,18725449 -> 18725449 blaSHV-11 WP_004176269.1 pubmed_reference: 9145849,9145849 -> 9145849 blaSHV-111 WP_063864614.1 pubmed_reference: 19343954,19343954 -> 19343954 blaSHV-120 WP_063864616.1 product_name: class A beta-lactamase SHV-120 -> class A extended-spectrum beta-lactamase SHV-120 pubmed_reference: -> 26409063 subclass: BETA-LACTAM -> CEPHALOSPORIN blaSHV-129 WP_032494802.1 pubmed_reference: 22322349,22322349 -> 22322349 blaSHV-13 WP_063864619.1 pubmed_reference: 10722518,10722518 -> 10722518 blaSHV-133 WP_063864621.1 product_name: class A beta-lactamase SHV-133 -> class A broad-spectrum beta-lactamase SHV-133 pubmed_reference: 24475919 -> 24475919, 32284385 blaSHV-135 WP_063864623.1 product_name: class A beta-lactamase SHV-135 -> class A broad-spectrum beta-lactamase SHV-135 blaSHV-137 WP_063864624.1 product_name: class A beta-lactamase SHV-137 -> class A broad-spectrum beta-lactamase SHV-137 pubmed_reference: -> 32284385 blaSHV-14 WP_063864625.1 pubmed_reference: 11120985,11120985 -> 11120985 blaSHV-141 WP_063864626.1 pubmed_reference: -> 25737290 blaSHV-142 WP_063864627.1 product_name: class A beta-lactamase SHV-142 -> class A broad-spectrum beta-lactamase SHV-142 pubmed_reference: 22537112,22537112 -> 22537112 blaSHV-143 WP_063864628.1 pubmed_reference: -> 25957381 blaSHV-145 WP_063864630.1 product_name: class A beta-lactamase SHV-145 -> class A broad-spectrum beta-lactamase SHV-145 pubmed_reference: -> 32284385 blaSHV-147 WP_063864632.1 product_name: class A beta-lactamase SHV-147 -> class A broad-spectrum beta-lactamase SHV-147 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-148 WP_063864633.1 product_name: class A extended-spectrum beta-lactamase SHV-148 -> class A broad-spectrum beta-lactamase SHV-148 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-149 WP_063864634.1 product_name: class A beta-lactamase SHV-149 -> class A broad-spectrum beta-lactamase SHV-149 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-150 WP_063864636.1 product_name: class A beta-lactamase SHV-150 -> class A broad-spectrum beta-lactamase SHV-150 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-151 WP_063864637.1 product_name: class A beta-lactamase SHV-151 -> class A broad-spectrum beta-lactamase SHV-151 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-152 WP_063864638.1 product_name: class A beta-lactamase SHV-152 -> class A extended-spectrum beta-lactamase SHV-152 blaSHV-153 WP_063864639.1 product_name: class A beta-lactamase SHV-153 -> class A extended-spectrum beta-lactamase SHV-153 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-154 WP_063864640.1 product_name: class A beta-lactamase SHV-154 -> class A extended-spectrum beta-lactamase SHV-154 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-155 WP_063864641.1 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-156 WP_063864642.1 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-157 WP_063864643.1 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-158 WP_063864644.1 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-159 WP_063864645.1 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-16 WP_063864646.1 pubmed_reference: 11502518,11502518 -> 11502518 blaSHV-160 WP_063864647.1 product_name: class A beta-lactamase SHV-160 -> class A extended-spectrum beta-lactamase SHV-160 pubmed_reference: 23587957 -> 23587957, 32284385 blaSHV-161 WP_063864648.1 product_name: class A beta-lactamase SHV-161 -> class A broad-spectrum beta-lactamase SHV-161 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-162 WP_063864649.1 product_name: class A beta-lactamase SHV-162 -> class A extended-spectrum beta-lactamase SHV-162 pubmed_reference: 23587957 -> 23587957, 32284385 blaSHV-163 WP_063864650.1 product_name: class A beta-lactamase SHV-163 -> class A extended-spectrum beta-lactamase SHV-163 pubmed_reference: 23587957,23587957 -> 23587957 blaSHV-165 WP_063864652.1 product_name: class A beta-lactamase SHV-165 -> class A extended-spectrum beta-lactamase SHV-165 pubmed_reference: 23587957,23587957 -> 23587957, 32284385 blaSHV-179 WP_063864657.1 product_name: class A beta-lactamase SHV-179 -> class A broad-spectrum beta-lactamase SHV-179 blaSHV-18 WP_063864658.1 pubmed_reference: 10952583,10952583 -> 10952583 blaSHV-185 WP_063864662.1 product_name: class A beta-lactamase SHV-185 -> class A broad-spectrum beta-lactamase SHV-185 blaSHV-187 WP_021440083.1 product_name: class A beta-lactamase SHV-187 -> class A broad-spectrum beta-lactamase SHV-187 blaSHV-189 WP_063864665.1 product_name: class A beta-lactamase SHV-189 -> class A broad-spectrum beta-lactamase SHV-189 blaSHV-24 WP_063864670.1 pubmed_reference: 10817740,10817740 -> 10817740 blaSHV-25 WP_063864671.1 pubmed_reference: 11502506,11502506 -> 11502506 blaSHV-26 WP_023280043.1 pubmed_reference: 11502506,11502506 -> 11502506 blaSHV-27 WP_023282555.1 product_name: class A extended-spectrum beta-lactamase SHV-27 -> class A broad-spectrum beta-lactamase SHV-27 pubmed_reference: 11266422,11266422 -> 11266422, 16584302 blaSHV-28 WP_004179754.1 product_name: class A beta-lactamase SHV-28 -> class A broad-spectrum beta-lactamase SHV-28 pubmed_reference: 21359845,19172061 -> 19172061, 21359845 blaSHV-29 WP_063864672.1 product_name: class A beta-lactamase SHV-29 -> class extended-spectrum A beta-lactamase SHV-29 pubmed_reference: 11257029,11257029 -> 11257029, 32284385 blaSHV-2A WP_032488413.1 pubmed_reference: 1741919,10223953 -> 10223953, 1741919 blaSHV-30 WP_032491180.1 pubmed_reference: 16251316,16251316 -> 16251316 blaSHV-31 WP_063864674.1 pubmed_reference: 17178800,17178800 -> 17178800 blaSHV-32 WP_063864675.1 pubmed_reference: 11557480,11557480 -> 11557480 blaSHV-33 WP_023325206.1 pubmed_reference: 11557480,11557480 -> 11557480 blaSHV-34 WP_063864676.1 pubmed_reference: 14613945,14613945 -> 14613945 blaSHV-36 WP_063864678.1 product_name: class A beta-lactamase SHV-36 -> class A broad-spectrum beta-lactamase SHV-36 pubmed_reference: 17913717 -> 17913717, 32625176 blaSHV-38 WP_063864680.1 pubmed_reference: 12543688,12543688 -> 12543688 subclass: CARBAPENEM -> CEPHALOSPORIN blaSHV-4 WP_152330890.1 product_name: class A beta-lactamase SHV-4 -> class A extended-spectrum beta-lactamase SHV-4 pubmed_reference: 2694955,2694955 -> 2086215, 2694955, 7814497 blaSHV-40 WP_063864681.1 product_name: class A extended-spectrum beta-lactamase SHV-40 -> class A broad-spectrum beta-lactamase SHV-40 pubmed_reference: 15047521,15047521 -> 15047521, 16769193 blaSHV-41 WP_063864682.1 product_name: class A extended-spectrum beta-lactamase SHV-41 -> class A broad-spectrum beta-lactamase SHV-41 pubmed_reference: 15047521,15047521 -> 15047521, 16584302 blaSHV-42 WP_063864683.1 product_name: class A extended-spectrum beta-lactamase SHV-42 -> class A broad-spectrum beta-lactamase SHV-42 pubmed_reference: 15047521,15047521 -> 15047521 blaSHV-43 WP_032490193.1 pubmed_reference: 12543694,12543694 -> 12543694 blaSHV-44 WP_063864684.1 pubmed_reference: 14576109,14576109 -> 14576109 blaSHV-46 WP_063864686.1 pubmed_reference: 14638498,14638498 -> 14638498 blaSHV-48 WP_063864687.1 pubmed_reference: 19075050,19075050 -> 19075050 blaSHV-49 WP_063864688.1 pubmed_reference: 15504885,15504885 -> 15504885 blaSHV-5 WP_011117369.1 pubmed_reference: 2088203,2088203 -> 2088203 blaSHV-50 WP_063864689.1 product_name: class A beta-lactamase SHV-50 -> class A broad-spectrum beta-lactamase SHV-50 blaSHV-51 WP_063864690.1 product_name: class A beta-lactamase SHV-51 -> class A broad-spectrum beta-lactamase SHV-51 pubmed_reference: -> 34182896 blaSHV-52 WP_063864691.1 product_name: class A beta-lactamase SHV-52 -> inhibitor-resistant class A broad-spectrum beta-lactamase SHV-52 pubmed_reference: -> 2086215 blaSHV-55 WP_063864692.1 pubmed_reference: 16938422,16938422 -> 16938422 blaSHV-56 WP_063864693.1 pubmed_reference: 18663019,18663019 -> 18663019 blaSHV-57 WP_032490632.1 pubmed_reference: 15673739,15673739 -> 15673739 blaSHV-59 WP_063864694.1 product_name: class A beta-lactamase SHV-59 -> class A broad-spectrum beta-lactamase SHV-59 blaSHV-60 WP_004183952.1 pubmed_reference: 19272757,19272757 -> 19272757 blaSHV-61 WP_063864695.1 pubmed_reference: 19272757,19272757 -> 19272757 blaSHV-62 WP_063864696.1 pubmed_reference: 19272757,19272757 -> 19272757 blaSHV-63 WP_063864697.1 product_name: class A beta-lactamase SHV-63 -> class A broad-spectrum beta-lactamase SHV-63 blaSHV-65 WP_063864699.1 product_name: class A beta-lactamase SHV-65 -> class A extended-spectrum beta-lactamase SHV-65 pubmed_reference: 17288792 -> 17288792, 26029910 blaSHV-7 WP_020316986.1 pubmed_reference: 7785992,7785992 -> 7785992 blaSHV-70 WP_032491403.1 pubmed_reference: 16563703,16563703 -> 16563703 blaSHV-72 WP_063864704.1 pubmed_reference: 18316518,18316518 -> 18316518 blaSHV-8 WP_063864710.1 pubmed_reference: 9056008,9056008 -> 9056008 blaSHV-85 WP_063864713.1 pubmed_reference: 18347108,18347108 -> 18347108 blaSHV-89 WP_032491601.1 pubmed_reference: 18587684,18587684 -> 18587684 blaSHV-9 WP_032488887.1 product_name: class A beta-lactamase SHV-9 -> class A extended-spectrum beta-lactamase SHV-9 blaSHV-92 WP_032491784.1 product_name: class A beta-lactamase SHV-92 -> inhibitor-resistant class A broad-spectrum beta-lactamase SHV-92 pubmed_reference: 18029415,18029415 -> 18029415, 25691639 blaSHV-95 WP_063864717.1 product_name: class A beta-lactamase SHV-95 -> class A broad-spectrum beta-lactamase SHV-95 blaSHV-97 WP_063864719.1 product_name: class A beta-lactamase SHV-97 -> class A extended-spectrum beta-lactamase SHV-97 pubmed_reference: 21940649 -> 21940649, 32284385 blaSHV-98 WP_063864720.1 product_name: class A extended-spectrum beta-lactamase SHV-98 -> class A broad-spectrum beta-lactamase SHV-98 pubmed_reference: 21415202,21415202 -> 21415202 blaSHV-99 WP_063864721.1 product_name: class A extended-spectrum beta-lactamase SHV-99 -> class A broad-spectrum beta-lactamase SHV-99 blaSME-1 WP_063864724.1 pubmed_reference: 8092824,8092824 -> 8092824 blaSME-2 WP_063864725.1 pubmed_reference: 11036019,11036019 -> 11036019 blaSME-3 WP_063864726.1 pubmed_reference: 17005839,17005839 -> 17005839 blaTEM-102 WP_063864794.1 pubmed_reference: 12878521,12878521 -> 12878521 blaTEM-109 WP_063864799.1 pubmed_reference: 16251281,16251281 -> 16251281 blaTEM-112 WP_063864802.1 pubmed_reference: 15282240,15282240 -> 15282240 blaTEM-113 WP_063864803.1 pubmed_reference: 15282240,15282240 -> 15282240 blaTEM-114 WP_063864804.1 pubmed_reference: 15282240,15282240 -> 15282240 blaTEM-115 WP_063864805.1 pubmed_reference: 15047521,15047521 -> 15047521 blaTEM-120 WP_063864806.1 pubmed_reference: 15047521,15047521 -> 15047521 blaTEM-121 WP_063864807.1 pubmed_reference: 15561821,15561821 -> 15561821 blaTEM-122 WP_063864808.1 pubmed_reference: 15105100,15105100 -> 15105100 blaTEM-125 WP_063864811.1 pubmed_reference: 16801418,16801418 -> 16801418 blaTEM-126 WP_063864819.1 pubmed_reference: 15282240,15282240 -> 15282240 blaTEM-127 WP_032490959.1 pubmed_reference: 15650379,15650379 -> 15650379 blaTEM-128 WP_032490960.1 pubmed_reference: 15650379,15650379 -> 15650379 blaTEM-129 WP_063864833.1 pubmed_reference: 15472005,15472005 -> 15472005 blaTEM-131 WP_063864850.1 pubmed_reference: 15504851,15504851 -> 15504851 blaTEM-132 WP_032490956.1 pubmed_reference: 15980402,15980402 -> 15980402 blaTEM-133 WP_063864851.1 pubmed_reference: 15855544,15855544 -> 15855544 blaTEM-134 WP_063864852.1 pubmed_reference: 15793140,15793140 -> 15793140 blaTEM-136 WP_063864853.1 pubmed_reference: 16531430,16531430 -> 16531430 blaTEM-137 WP_063864854.1 pubmed_reference: 17561568,17561568 -> 17561568 blaTEM-138 WP_032491283.1 pubmed_reference: 16940125,16940125 -> 16940125 blaTEM-139 WP_032491449.1 pubmed_reference: 17382521,17382521 -> 17382521 blaTEM-141 WP_032491376.1 pubmed_reference: 17881870,17881870 -> 17881870 blaTEM-144 WP_021598056.1 pubmed_reference: 16436745,16436745 -> 16436745 blaTEM-149 WP_063864860.1 pubmed_reference: 18160520,18160520 -> 18160520 blaTEM-151 WP_063864862.1 pubmed_reference: 17220412,17220412 -> 17220412 blaTEM-152 WP_063864863.1 pubmed_reference: 17220412,17220412 -> 17220412 blaTEM-153 WP_063864864.1 pubmed_reference: 23579192,23579192 -> 23579192 blaTEM-154 WP_063864865.1 pubmed_reference: 17913717,17913717 -> 17913717 blaTEM-155 WP_063864866.1 pubmed_reference: 19075050,19075050 -> 19075050 blaTEM-158 WP_063864868.1 pubmed_reference: 17709463,17709463 -> 17709463 blaTEM-159 WP_063864869.1 pubmed_reference: 18292096,18292096 -> 18292096 blaTEM-160 WP_063864871.1 pubmed_reference: 18292096,18292096 -> 18292096 blaTEM-164 WP_032492113.1 pubmed_reference: 19728777,19728777 -> 19728777 blaTEM-168 WP_063864876.1 pubmed_reference: 19687235,19687235 -> 19687235 blaTEM-17 WP_063864877.1 pubmed_reference: 10681352,10681352 -> 10681352 blaTEM-177 WP_063864878.1 pubmed_reference: 23210906,23210906 -> 23210906 blaTEM-178 WP_063864879.1 pubmed_reference: 9371336,9371336 -> 9371336 blaTEM-181 WP_000027060.1 pubmed_reference: 21947397,21947397 -> 21947397 blaTEM-182 WP_063864880.1 pubmed_reference: 23335113,23335113 -> 23335113 blaTEM-186 WP_063864884.1 pubmed_reference: 22397509,22397509 -> 22397509 blaTEM-187 WP_032494853.1 pubmed_reference: 23478954,23478954 -> 23478954 blaTEM-19 WP_033560332.1 pubmed_reference: 2073111,2073111 -> 2073111 blaTEM-191 WP_077064889.1 product_name: class A beta-lactamase TEM-191 -> class A extended-spectrum beta-lactamase TEM-191 pubmed_reference: 22718774 -> 22718774, 26409063 subclass: BETA-LACTAM -> CEPHALOSPORIN blaTEM-26 WP_047028173.1 pubmed_reference: 1416892,1416892 -> 1416892 blaTEM-28 WP_063864909.1 pubmed_reference: 8787920,8787920 -> 8787920 blaTEM-29 WP_032490103.1 pubmed_reference: 8586268,8586268 -> 8586268 blaTEM-34 WP_015379489.1 pubmed_reference: 8067742,8067742 -> 8067742 blaTEM-40 WP_021526512.1 pubmed_reference: 8585729,8585729 -> 8585729 blaTEM-43 WP_063864912.1 pubmed_reference: 9661002,9661002 -> 9661002 blaTEM-45 WP_063864913.1 pubmed_reference: 9021194,9021194 -> 9021194 blaTEM-47 WP_063864914.1 pubmed_reference: 9517925,9517925 -> 9517925 blaTEM-48 WP_063864915.1 pubmed_reference: 9517925,9517925 -> 9517925 blaTEM-49 WP_063864916.1 pubmed_reference: 9517925,9517925 -> 9517925 blaTEM-52 WP_015058977.1 pubmed_reference: 9449269,9449269 -> 9449269 blaTEM-53 WP_063864923.1 pubmed_reference: 9925535,9925535 -> 9925535 blaTEM-54 WP_063864930.1 pubmed_reference: 9925535,9925535 -> 9925535 blaTEM-57 WP_032492330.1 pubmed_reference: 10543745,10543745 -> 10543745 blaTEM-6 WP_063864949.1 pubmed_reference: 3312022,3312022 -> 3312022 blaTEM-60 WP_032489150.1 pubmed_reference: 9624494,9624494 -> 9624494 blaTEM-63 WP_055314004.1 pubmed_reference: 11120950,11120950 -> 11120950 blaTEM-67 WP_032490504.1 pubmed_reference: 12499163,12499163 -> 12499163 blaTEM-71 WP_032490155.1 pubmed_reference: 12019125,12019125 -> 12019125 blaTEM-72 WP_032489614.1 pubmed_reference: 10952610,10952610 -> 10952610 blaTEM-76 WP_063864990.1 pubmed_reference: 10991849,10991849 -> 10991849 blaTEM-77 WP_063864996.1 pubmed_reference: 10991849,10543745 -> 10543745, 10991849 blaTEM-78 WP_063865003.1 pubmed_reference: 10991849,10991849 -> 10991849 blaTEM-79 WP_063865008.1 pubmed_reference: 10991849,10991849 -> 10991849 blaTEM-80 WP_063865024.1 pubmed_reference: 11959543,11959543 -> 11959543 blaTEM-81 WP_063865030.1 pubmed_reference: 10991849,10991849 -> 10991849 blaTEM-82 WP_063865036.1 pubmed_reference: 10991849,10991849 -> 10991849 blaTEM-83 WP_063865043.1 pubmed_reference: 10991849,10991849 -> 10991849 blaTEM-84 WP_063865053.1 pubmed_reference: 10991849,10991849 -> 10991849 blaTEM-85 WP_032490101.1 pubmed_reference: 15855509,15855509 -> 15855509 blaTEM-86 WP_032490102.1 pubmed_reference: 15855509,15855509 -> 15855509 blaTEM-87 WP_032489893.1 pubmed_reference: 11850290,11850290 -> 11850290 blaTEM-88 WP_032489980.1 pubmed_reference: 11709362,11709362 -> 11709362 blaTEM-90 WP_032490026.1 pubmed_reference: 11557499,11557499 -> 11557499 blaTEM-91 WP_063865088.1 pubmed_reference: 12937007,12937007 -> 12937007 blaTEM-93 WP_032490317.1 pubmed_reference: 15855509,15855509 -> 15855509 blaTEM-94 WP_032490318.1 pubmed_reference: 15855509,15855509 -> 15855509 blaTEM-95 WP_061659705.1 pubmed_reference: 12234838,12234838 -> 12234838 blaVEB-2 WP_063865158.1 pubmed_reference: 11807680,11807680 -> 11807680 blaVEB-3 WP_020956917.1 pubmed_reference: 15695687,15695687 -> 15695687 blaVEB-4 WP_063865159.1 pubmed_reference: 18292096,18292096 -> 18292096 blaVEB-6 WP_063865161.1 pubmed_reference: 18025117,18025117 -> 18025117 blaVIM-1 WP_013263789.1 pubmed_reference: 10390207,18804966 -> 10390207, 18804966 blaVIM-11 WP_034080264.1 pubmed_reference: 15616342,15616342 -> 15616342 blaVIM-12 WP_063865167.1 pubmed_reference: 16304191,16304191 -> 16304191 blaVIM-13 WP_063865168.1 pubmed_reference: 18644957,18644957 -> 18644957 blaVIM-14 WP_063865169.1 pubmed_reference: 21521413,21521413 -> 21521413 blaVIM-15 WP_063865170.1 pubmed_reference: 18519714,18519714 -> 18519714 blaVIM-16 WP_063865171.1 pubmed_reference: 18519714,18519714 -> 18519714 blaVIM-17 WP_023442721.1 pubmed_reference: 19164147,19164147 -> 19164147 blaVIM-18 WP_063865172.1 pubmed_reference: 19164147,19114677 -> 19114677, 19164147 blaVIM-19 WP_032492472.1 pubmed_reference: 19917750,19917750 -> 19917750 blaVIM-2 WP_003108247.1 pubmed_reference: 10722487,18804966 -> 10722487, 18804966 blaVIM-23 WP_063865174.1 pubmed_reference: 20961909,20961909 -> 20961909 blaVIM-24 WP_063865175.1 pubmed_reference: 21282438,21282438 -> 21282438 blaVIM-27 WP_032495187.1 pubmed_reference: 21518835,21518835 -> 21518835 blaVIM-3 WP_063865179.1 pubmed_reference: 11451678,11451678 -> 11451678 blaVIM-31 WP_063865181.1 pubmed_reference: 22391550,22391550 -> 22391550 blaVIM-33 WP_063865183.1 pubmed_reference: 24185874,23070171 -> 23070171, 24185874 blaVIM-34 WP_063865184.1 pubmed_reference: 23934739,23934739 -> 23934739 blaVIM-36 WP_063865186.1 pubmed_reference: 24603963,24603963 -> 24603963 blaVIM-37 WP_063865187.1 pubmed_reference: 24603963,24603963 -> 24603963 blaVIM-38 WP_063865188.1 pubmed_reference: 24428980,24428980 -> 24428980 blaVIM-4 WP_032492008.1 pubmed_reference: 12435718,12435718 -> 12435718 blaVIM-5 WP_032491390.1 pubmed_reference: 15190017,15190017 -> 15190017 blaVIM-6 WP_063865201.1 pubmed_reference: 15155248,15155248 -> 15155248 blaVIM-7 WP_011997479.1 pubmed_reference: 23014719,14693560 -> 14693560, 23014719 blaVIM-8 WP_063865202.1 pubmed_reference: 15528701,15528701 -> 15528701 ftsI_A515V WP_000227936.1 product_name: penicillin-binding protein PBP3 ftsI -> penicillin-binding protein PBP3 FtsI qnrE3 WP_010431379.1 pubmed_reference: -> 34097486 qnrE4 WP_047174394.1 pubmed_reference: -> 34097486 tmexC1 WP_118842626.1 allele: -> tmexC1 gene_family: tmexC1 -> tmexC tmexD1 WP_118842627.1 allele: -> tmexD1 gene_family: tmexD1 -> tmexD toprJ1 WP_003152694.1 allele: -> toprJ1 gene_family: toprJ1 -> toprJ Added families aph(3')-IId - aminoglycoside O-phosphotransferase APH(3')-IId arsB - arsenite efflux transporter membrane subunit ArsB arsD2 - arsenite efflux transporter metallochaperone ArsD-related protein arsR - As(III)-sensing metalloregulatory transcriptional repressor ArsR arsR - As(III)-sensing metalloregulatory transcriptional repressor ArsR arsR - As(III)-sensing metalloregulatory transcriptional repressor ArsR bcrA - bacitracin resistance ABC transporter ATP-binding subunit BcrA blaASU1 - ASU1 family class A beta-lactamase blaB3SU1 - B3SU1 family subclass B3 metallo-beta-lactamase blaB3SU2 - B3SU2 family subclass B3 metallo-beta-lactamase blaLAQ - LAQ family class C beta-lactamase blaOXA NF038386.1 OXA-294 family class D beta-lactamase blaPAD NF040472.1 PAD family carbapenem-hydrolyzing class A beta-lactamase blaPAM - PAM family subclass B3 metallo-beta-lactamase blaSFDC - SFDC family class C beta-lactamase blaVAM - VAM family subclass B1 metallo-beta-lactamase cadA - cadmium-translocating P-type ATPase CadA cadC - Cd(II)-sensing metalloregulatory transcriptional repressor CadC qacH - quaternary ammonium compound efflux SMR transporter QacH tmexC - multidrug efflux RND transporter periplasmic adaptor subunit TMexC tmexD - multidrug efflux RND transporter permease subunit TMexD toprJ - multidrug efflux transporter outer membrane subunit TOprJ Removed families cpt - chloramphenicol phosphotransferase CPT family protein mexC - MexC family multidrug efflux RND transporter periplasmic adaptor subunit mexD - multidrug efflux RND transporter permease subunit MexD oprJ - multidrug efflux transporter outer membrane subunit OprJ tmexC1 - multidrug efflux RND transporter periplasmic adaptor subunit TMexC1 tmexD1 - multidrug efflux RND transporter permease subunit TMexD1 toprJ1 - multidrug efflux transporter outer membrane subunit TOprJ1 Family changes blaEAM EAM family subclass B3 metallo-beta-lactamase hmm_id: - -> NF040470.1 blaECM ECM family subclass B3 metallo-beta-lactamase hmm_id: - -> NF040468.1 blaEFM EFM family subclass B3 metallo-beta-lactamase hmm_id: - -> NF040469.1 blaORN ORN family class A beta-lactamase hmm_id: - -> NF038401.1 blaPLA PLA family class A beta-lactamase hmm_id: - -> NF038398.1 bla PLA/ORN/TER family class A beta-lactamase gene_symbol: blaPLA -> bla blaTER TER family class A beta-lactamase hmm_id: - -> NF038400.1 ---------------------------------------------------------------------- Changes included in 2021-06-01.1 ---------------------------------------------------------------------- Overview: - This update includes a new "Synonyms" column in the Reference Gene Catalog populated with alternative gene symbols that may sometimes have been used to refer to the same gene. - Many Klebsiella virulence genes added - Toxin genes from Staph aureus added - Tigecycline resistance genes and mutations in Klebsiella added - CLASS/SUBCLASS added for some metal-resistance genes previously missing them - A couple of refinements of subclass and scope based on functional evidence - New HMM for DfrA12/DfrA21 family proteins - Changes made to disambiguate the two uses of blaNDM-16 - NCBI is now curating alleles for CfiA - The usual addition of new alleles submitted to NCBI Statement about nomenclature decisions for CfiA: NCBI has added CfiA (also known as CcrA) to the set of beta-lactamase families for which we will provide advice and a reservation system for allele assignments, linked to sequence submission to GenBank, and provide annotation that we consider official. This follows our consultation with several community experts in that family. Our coverage should help codify the resolution to some past collisions and conflicts in names of cfiA alleles. The nomenclature we are settling on mostly follows Litterio, et al. (PMID:29017951, 2017, with senior author Marcela Radice), but with a few exceptions, as follows: The first allele described, first named cfiA (cefoxitin and imipenem) in 1990 and then ccrA (carbapenem- and cephamycin resistance) later that same year, will remain cfiA, for best continuity with a large literature, rather than cfiA13 as proposed in PMID:29017951. The allele that has been called cfiA1, cfiA2, cfiA3, and cfiA6 will remain cfiA2 in our Reference Gene Catalog, as in past releases, to avoid the possibly incorrect assumption that the sequence represented is the founding member of the family. We will continue to recognize AAR04097.1 as cfiA11, following PMID:20226324 (2010), rather than renaming to cfiA20 as suggested in PMID:29017951 (2017). Statement about nomenclature decisions for blaNDM-16: We noticed recently two different usages of the allele assignment blaNDM-16. The more common allele was discussed critically in two articles, PMID:30147347 and PMID:29909397, one of which characterized the contributions of individual residue changes to zinc affinity and thermostability. The other assignment was official, as part of the beta-lactamase allele number reservation system run previously at Lahey Clinic and now at NCBI. After review of the literature and consultation with recent submitters, we have chosen to update the allele assignments for these two proteins. The original Lahey-assigned NDM-16 (AKZ20823.1 and all identical proteins) is now NDM-16a, while BCO01847.1 (and all identical proteins) is now NDM-16b, with NDM-32 as a synonym. This handling is intended to protect links to discussions in the literature without misleading on which protein is meant. Summary: Total proteins: 6782 Core proteins: 5829 Plus proteins: 953 AMR proteins: 5871 STRESS proteins: 211 VIRULENCE proteins: 700 Point mutations: 745 Point mutation references: 108 Point mutation organism groups: Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 631 Updates since release 2021-03-01.1: Proteins added: 132 Core proteins added: 70 Plus proteins added: 62 AMR proteins added: 71 VIRULENCE proteins added: 61 Alleles added: 66 Point mutations added: 17 Proteins removed: 0 Reference Gene Catalog entries changed: 39 Families added: 67 Families removed: 0 Families changed: 1 Added proteins core AMR AMR toprJ1 NG_074694.1 WP_003152694.1 multidrug efflux transporter outer membrane subunit TOprJ1 mef(F) NG_074691.1 WP_101035418.1 macrolide efflux MFS transporter Mef(F) tmexC1 NG_074692.1 WP_118842626.1 multidrug efflux RND transporter periplasmic adaptor subunit TMexC1 tmexD1 NG_074693.1 WP_118842627.1 multidrug efflux RND transporter permease subunit TMexD1 blaACT-88 NG_074695.1 WP_181240047.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-88 blaACT-89 NG_074696.1 WP_049134845.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-89 blaAFM-3 NG_074697.1 WP_211862582.1 subclass B1 metallo-beta-lactamase AFM-3 blaAXC-6 NG_074698.1 WP_213994577.1 carbapenem-hydrolyzing class A beta-lactamase AXC-6 blaCARB-56 NG_074699.1 WP_017821520.1 carbenicillin-hydrolyzing class A beta-lactamase CARB-56 blaCARB-57 NG_074700.1 WP_005391263.1 carbenicillin-hydrolyzing class A beta-lactamase CARB-57 blaCMY-175 NG_074701.1 WP_213994578.1 class C beta-lactamase CMY-175 blaCMY-176 NG_074702.1 WP_213994579.1 class C beta-lactamase CMY-176 blaCTX-M-243 NG_074703.1 WP_213994580.1 class A extended-spectrum beta-lactamase CTX-M-243 blaCTX-M-245 NG_074704.1 WP_213994581.1 class A extended-spectrum beta-lactamase CTX-M-245 blaCTX-M-246 NG_074705.1 WP_213994582.1 class A extended-spectrum beta-lactamase CTX-M-246 blaFOX-18 NG_074706.1 WP_213994583.1 cephalosporin-hydrolyzing class C beta-lactamase FOX-18 blaFOX-19 NG_074707.1 WP_213994584.1 cephalosporin-hydrolyzing class C beta-lactamase FOX-19 blaGES-47 NG_074708.1 WP_213994585.1 carbapenem-hydrolyzing class A beta-lactamase GES-47 blaGES-48 NG_074709.1 WP_213994586.1 carbapenem-hydrolyzing class A beta-lactamase GES-48 blaGOB-3 NG_074710.1 WP_078411523.1 subclass B3 metallo-beta-lactamase GOB-3 blaGOB-4 NG_074711.1 WP_078691374.1 subclass B3 metallo-beta-lactamase GOB-4 blaGOB-6 NG_074712.1 WP_069147617.1 subclass B3 metallo-beta-lactamase GOB-6 blaIMP-90 NG_074713.1 WP_213994587.1 subclass B1 metallo-beta-lactamase IMP-90 blaKPC-47 NG_074714.1 WP_213994588.1 carbapenem-hydrolyzing class A beta-lactamase KPC-47 blaKPC-48 NG_074715.1 WP_213994589.1 carbapenem-hydrolyzing class A beta-lactamase KPC-48 blaKPC-67 NG_074716.1 WP_210204487.1 class A beta-lactamase KPC-67 blaKPC-68 NG_074717.1 WP_210204468.1 class A beta-lactamase KPC-68 blaKPC-69 NG_074718.1 WP_210205486.1 class A beta-lactamase KPC-69 blaKPC-70 NG_074719.1 WP_210205477.1 class A beta-lactamase KPC-70 blaKPC-84 NG_074720.1 WP_213994590.1 carbapenem-hydrolyzing class A beta-lactamase KPC-84 blaKPC-85 NG_074721.1 WP_213994591.1 carbapenem-hydrolyzing class A beta-lactamase KPC-85 blaKPC-86 NG_074722.1 WP_213994592.1 carbapenem-hydrolyzing class A beta-lactamase KPC-86 blaKPC-87 NG_074723.1 WP_213994593.1 carbapenem-hydrolyzing class A beta-lactamase KPC-87 blaKPC-88 NG_074724.1 WP_213994594.1 carbapenem-hydrolyzing class A beta-lactamase KPC-88 blaMOX-15 NG_074725.1 WP_103261726.1 CMY-1/MOX family class C beta-lactamase MOX-15 blaNDM-16b NG_074726.1 WP_133963898.1 subclass B1 metallo-beta-lactamase NDM-16b blaOXA-790 NG_074727.1 WP_213994595.1 OXA-114 family class D beta-lactamase OXA-790 blaOXA-791 NG_074728.1 WP_213994596.1 OXA-114 family class D beta-lactamase OXA-791 blaOXA-950 NG_074729.1 WP_029305121.1 OXA-12 family class D beta-lactamase OXA-950 blaOXA-951 NG_074730.1 WP_213994597.1 OXA-12 family class D beta-lactamase OXA-951 blaOXA-952 NG_074731.1 WP_213994598.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-952 blaOXA-953 NG_074732.1 WP_049044515.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-953 blaOXA-954 NG_074733.1 WP_213994599.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-954 blaOXA-955 NG_074734.1 WP_213994600.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-955 blaOXA-956 NG_074735.1 WP_021139936.1 class D beta-lactamase OXA-956 blaOXA-958 NG_074736.1 WP_058052637.1 OXA-12 family class D beta-lactamase OXA-958 blaOXA-959 NG_074737.1 WP_075112279.1 OXA-12 family class D beta-lactamase OXA-959 blaOXA-960 NG_074738.1 WP_213994601.1 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-960 blaOXA-961 NG_074739.1 WP_213994602.1 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-961 blaOXA-962 NG_074740.1 WP_052248074.1 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-962 blaOXA-963 NG_074741.1 WP_213994603.1 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-963 blaOXA-964 NG_074742.1 WP_025889747.1 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-964 blaOXA-965 NG_074743.1 WP_213994604.1 OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-965 blaPDC-477 NG_074744.1 WP_213994605.1 class C beta-lactamase PDC-477 blaPDC-478 NG_074745.1 WP_213994606.1 class C beta-lactamase PDC-478 blaPDC-479 NG_074746.1 WP_213994607.1 class C beta-lactamase PDC-479 blaPDC-480 NG_074747.1 WP_213994608.1 class C beta-lactamase PDC-480 blaPDC-481 NG_074748.1 WP_213994609.1 class C beta-lactamase PDC-481 blaPDC-482 NG_074749.1 WP_213994610.1 class C beta-lactamase PDC-482 blaPDC-483 NG_074750.1 WP_213994611.1 class C beta-lactamase PDC-483 blaROB-11 NG_074751.1 WP_132995818.1 class A beta-lactamase ROB-11 blaROB-12 NG_074752.1 WP_213994612.1 class A beta-lactamase ROB-12 blaROB-9 NG_074753.1 WP_172693371.1 class A beta-lactamase ROB-9 blaVIM-74 NG_074754.1 WP_213994613.1 subclass B1 metallo-beta-lactamase VIM-74 mcr-1.31 NG_074755.1 WP_213994614.1 phosphoethanolamine--lipid A transferase MCR-1.31 mcr-1.32 NG_074756.1 WP_213994615.1 phosphoethanolamine--lipid A transferase MCR-1.32 mcr-8.4 NG_074757.1 WP_118860654.1 phosphoethanolamine--lipid A transferase MCR-8.4 qnrE3 NG_074758.1 WP_010431379.1 quinolone resistance pentapeptide repeat protein QnrE3 qnrE4 NG_074759.1 WP_047174394.1 quinolone resistance pentapeptide repeat protein QnrE4 qnrVC8 NG_074760.1 WP_206627591.1 quinolone resistance pentapeptide repeat protein QnrVC8 plus AMR AMR catC JPIP01000949.1 KGT34314.1 type B chloramphenicol O-acetyltransferase plus VIRULENCE VIRULENCE seh U11702.1 AAA19777.1 staphylococcal enterotoxin type H see M21319.1 AAA26617.1 staphylococcal enterotoxin type E sec2 M28364.1 AAA26624.1 staphylococcal enterotoxin type C2 eta M17347.1 AAA26625.1 exfoliative toxin A etb M17348.1 AAA26628.1 exfoliative toxin B tst J02615.1 AAA26682.1 toxic shock syndrome toxin TSST-1 seb M11118.1 AAA88550.1 staphylococcal enterotoxin type B sed M28521.1 AAB06195.1 staphylococcal enterotoxin type D sej AF053140.1 AAC78590.1 staphylococcal enterotoxin type J iucD AF141323.1 AAD44749.1 NADPH-dependent L-lysine N(6)-monooxygenase IucD iucC AE014075.1 AAN82073.1 NIS family aerobactin synthetase IucC iucB AE014075.1 AAN82074.1 N(6)-hydroxylysine O-acetyltransferase IucB rmpA2 AY378100.1 AAR07704.1 mucoid phenotype regulator RmpA2 sek CP000046.1 AAW36439.1 staphylococcal enterotoxin type K splE CP000253.1 ABD30999.1 serine protease SplE splB CP000253.1 ABD31003.1 serine protease SplB splA CP000253.1 ABD31004.1 serine protease SplA selV EF030427.1 ABK27165.1 staphylococcal enterotoxin type V iroD CP001232.1 ACJ63529.1 catecholate siderophore esterase IroD sel31 GQ900475.1 ACZ66176.1 staphylococcal enterotoxin type 31 sep CP001844.2 ADC38120.1 staphylococcal enterotoxin type P scn CP002114.2 ADL23798.1 complement inhibitor SCIN-A selX HQ850970.1 AEI60187.1 staphylococcal enterotoxin-like toxin X lukS-PV CP003603.1 AGW33874.1 Panton-Valentine bi-component leukocidin subunit S rmpC CP009208.1 AIK83625.1 mucoid phenotype regulator RmpC rmpA CP014009.1 AMA27886.1 mucoid phenotype regulator RmpA sel CP014064.2 AMG40538.1 staphylococcal enterotoxin type L iroC MG649035.1 AUH19662.1 salmochelin/enterobactin export ABC transporter IroC rmpD CP025630.1 AUN52700.1 mucoid phenotype synthesis protein RmpD hlgA CP026068.1 AUU54669.1 bi-component gamma-hemolysin HlgAB subunit A icaC CP026070.1 AUU58561.1 polysaccharide intercellular adhesin biosynthesis/export protein IcaC iroD KY454627.1 AVE24993.1 catecholate siderophore esterase IroD ednB MH115577.1 AXN77488.1 epidermal cell differentiation inhibitor EdnB lukF-PV AB006796.1 BAA24008.1 Panton-Valentine bi-component leukocidin subunit F seo BA000018.3 BAB42916.1 staphylococcal enterotoxin type O sec3 BA000018.3 BAB43097.1 staphylococcal enterotoxin type C3 cna BA000033.2 BAB96477.1 collagen adhesin Cna set AB330135.1 BAG06666.1 staphylococcal enterotoxin type T ses AB330135.1 BAG06667.1 staphylococcal enterotoxin type S sey AB924045.1 BAS21358.1 staphylococcal enterotoxin type Y sea LC129040.1 BAV60816.1 staphylococcal enterotoxin type A sak X00127.1 CAA24957.1 staphylokinase sec1 X05815.1 CAA29260.1 staphylococcal enterotoxin type C1 hlgC X81586.1 CAA57277.1 bi-component gamma-hemolysin HlgCB subunit C hlgB X81586.1 CAA57278.1 bi-component gamma-hemolysin HlgAB/HlgCB subunit B lukD Y13225.1 CAA73668.1 bi-component leukocidin LukED subunit D sel33 FGMI01000018.1 CXT91862.1 staphylococcal enterotoxin type 33 sel32 AFTU01000025.1 EGS90476.1 staphylococcal enterotoxin type 32 iroB ASVE01000004.1 EOW04219.1 salmochelin biosynthesis C-glycosyltransferase IroB ser JDNQ01000016.1 EVY93839.1 staphylococcal enterotoxin type R seq JGOY01000001.1 EYN56163.1 staphylococcal enterotoxin type Q sel26 JIJZ01000001.1 KAG18833.1 staphylococcal enterotoxin type 26 sel27 JAAFMT010000017.1 NDR16746.1 staphylococcal enterotoxin type 27 sel28 JAAFMT010000017.1 NDR16747.1 staphylococcal enterotoxin type 28 rmpD MT035874.1 QIK04195.1 mucoid phenotype synthesis protein RmpD sen FKWK01000010.1 SAO78304.1 staphylococcal enterotoxin type N seu FQDL01000019.1 SGR88168.1 staphylococcal enterotoxin type U sei FQDL01000019.1 SGR88193.1 staphylococcal enterotoxin type I sem FQDL01000019.1 SGR88215.1 staphylococcal enterotoxin type M selZ UHAS01000001.1 SUK32596.1 staphylococcal enterotoxin type Z sel30 UHBH01000001.1 SUK66413.1 staphylococcal enterotoxin type 30 Added point mutations core AMR POINT acrR_M109I TIGECYCLINE Klebsiella acrR_V165I TIGECYCLINE Klebsiella acrR_Y114F TIGECYCLINE Klebsiella gyrA_S83I QUINOLONE Salmonella oqxR_D95E TIGECYCLINE Klebsiella oqxR_F6S TIGECYCLINE Klebsiella oqxR_Q11L TIGECYCLINE Klebsiella oqxR_V102G TIGECYCLINE Klebsiella oqxR_V113I TIGECYCLINE Klebsiella ramR_A16D TIGECYCLINE Klebsiella ramR_A183D TIGECYCLINE Klebsiella ramR_A19V TIGECYCLINE Klebsiella ramR_I88N TIGECYCLINE Klebsiella ramR_K5E TIGECYCLINE Klebsiella ramR_T162I TIGECYCLINE Klebsiella ramR_T43M TIGECYCLINE Klebsiella rpsJ_V57L TIGECYCLINE Klebsiella Changed reference gene catalog records aac(3)-Ih ABL71428.1 scope: core -> plus arsR AAA25636.1 class: -> ARSENIC subclass: -> ARSENIC copC AAA25808.1 class: -> COPPER subclass: -> COPPER arsR AAA27587.1 class: -> ARSENIC subclass: -> ARSENIC nccX AAA65102.1 class: -> CADMIUM/COBALT/NICKEL subclass: -> CADMIUM/COBALT/NICKEL arsR AAB09624.1 class: -> ARSENIC subclass: -> ARSENIC iutA AAN45165.2 pubmed_reference: -> 21108814, 30371343 arsR ADZ44504.1 class: -> ARSENIC subclass: -> ARSENIC arsR BAE77793.1 class: -> ARSENIC subclass: -> ARSENIC iucA EGI25746.1 pubmed_reference: -> 30371343, 32432457 pbp2x WP_000872264.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp2x WP_000872267.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp2x WP_000872270.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp2x WP_000872271.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp2x WP_000872273.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp2x WP_000872275.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp2x WP_000872277.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp2x WP_000872282.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp1a WP_001039998.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A pbp1a WP_001040004.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A pbp1a WP_001040010.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A pbp1a WP_001040013.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A pbp2b WP_001224867.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B pbp2b WP_001224871.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B pbp2b WP_001224884.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B pbp2b WP_001224885.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B pbp2b WP_001224886.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B apmA WP_015059965.1 subclass: AMINOGLYCOSIDE -> APRAMYCIN apmA WP_032494221.1 pubmed_reference: 20876371 -> 20876371, 33563840 subclass: AMINOGLYCOSIDE -> APRAMYCIN pbp2x WP_033707918.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp1a WP_050078510.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A pbp1a WP_050208712.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A pbp2x WP_050293540.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp2x WP_054364452.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X pbp1a WP_054370471.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A pbp2b WP_061634854.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B pbp2x WP_061745305.1 product_name: Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X blaNDM-16a WP_063860859.1 allele: blaNDM-16 -> blaNDM-16a product_name: subclass B1 metallo-beta-lactamase NDM-16 -> subclass B1 metallo-beta-lactamase NDM-16a cfiA WP_005808062.1 allele: cfiA13 -> cfiA product_name: subclass B1 metallo-beta-lactamase CcrA -> subclass B1 metallo-beta-lactamase CfiA/CcrA Added families catC - type B chloramphenicol O-acetyltransferase cna - collagen adhesin Cna ednB - epidermal cell differentiation inhibitor EdnB eta - exfoliative toxin A etb - exfoliative toxin B hlgA - bi-component gamma-hemolysin HlgAB subunit A hlgB - bi-component gamma-hemolysin HlgAB/HlgCB subunit B hlgC - bi-component gamma-hemolysin HlgCB subunit C icaC - polysaccharide intercellular adhesin biosynthesis/export protein IcaC iroB - salmochelin biosynthesis C-glycosyltransferase IroB iroC - salmochelin/enterobactin export ABC transporter IroC iroD - catecholate siderophore esterase IroD iucB - N(6)-hydroxylysine O-acetyltransferase IucB iucC - NIS family aerobactin synthetase IucC iucD - NADPH-dependent L-lysine N(6)-monooxygenase IucD lukD - bi-component leukocidin LukED subunit D lukF-PV - Panton-Valentine bi-component leukocidin subunit F lukS-PV - Panton-Valentine bi-component leukocidin subunit S mef(F) - macrolide efflux MFS transporter Mef(F) mexC - MexC family multidrug efflux RND transporter periplasmic adaptor subunit mexD - multidrug efflux RND transporter permease subunit MexD oprJ - multidrug efflux transporter outer membrane subunit OprJ rmpA - mucoid phenotype regulator RmpA rmpA2 - mucoid phenotype regulator RmpA2 rmpC - mucoid phenotype regulator RmpC rmpD - mucoid phenotype synthesis protein RmpD sak - staphylokinase scn - complement inhibitor SCIN-A sea - staphylococcal enterotoxin type A seb - staphylococcal enterotoxin type B sec1 - staphylococcal enterotoxin type C1 sec2 - staphylococcal enterotoxin type C2 sec3 - staphylococcal enterotoxin type C3 sed - staphylococcal enterotoxin type D see - staphylococcal enterotoxin type E seh - staphylococcal enterotoxin type H sei - staphylococcal enterotoxin type I sej - staphylococcal enterotoxin type J sek - staphylococcal enterotoxin type K sel - staphylococcal enterotoxin type L sel26 - staphylococcal enterotoxin type 26 sel27 - staphylococcal enterotoxin type 27 sel28 - staphylococcal enterotoxin type 28 sel30 - staphylococcal enterotoxin type 30 sel31 - staphylococcal enterotoxin type 31 sel32 - staphylococcal enterotoxin type 32 sel33 - staphylococcal enterotoxin type 33 selV - staphylococcal enterotoxin type V selX - staphylococcal enterotoxin-like toxin X selZ - staphylococcal enterotoxin type Z sem - staphylococcal enterotoxin type M sen - staphylococcal enterotoxin type N seo - staphylococcal enterotoxin type O sep - staphylococcal enterotoxin type P seq - staphylococcal enterotoxin type Q ser - staphylococcal enterotoxin type R ses - staphylococcal enterotoxin type S set - staphylococcal enterotoxin type T seu - staphylococcal enterotoxin type U sey - staphylococcal enterotoxin type Y splA - serine protease SplA splB - serine protease SplB splE - serine protease SplE tmexC1 - multidrug efflux RND transporter periplasmic adaptor subunit TMexC1 tmexD1 - multidrug efflux RND transporter permease subunit TMexD1 toprJ1 - multidrug efflux transporter outer membrane subunit TOprJ1 tst - toxic shock syndrome toxin TSST-1 Family changes dfrA DfrA12/DfrA21 family trimethoprim-resistant dihydrofolate reductase hmm_id: - -> NF000055.3 ---------------------------------------------------------------------- Changes included in 2021-03-01.1 ---------------------------------------------------------------------- AMRFinderPlus database / Reference Gene Catalog version 2021-03-01.1 AMRFinderPlus software version 3.10.1 This is a significant update that includes reorganizations of two important gene families (dfr and tet) as well as new functionality to handle Penicillin resistant pbp alleles in Streptococcus pneumoniae. These updates required changes to the database format and a new version of the AMRFinderPlus software. More detailed explanations of major changes follow the summary. To use this database release you will need to upgrade to an AMRFinderPlus software version in the 3.10 series. See https://github.com/ncbi/amr/wiki/Upgrading for details on how to upgrade the AMRFinderPlus software. Overview of notable changes: - New handling of pbp alleles in Streptococcus pneumoniae where instead of identifying individual mutations AMRFinderPlus identifies divergent pbp alleles that are likely to be penicillin resistant - Reorganization and/or renaming of some dfr and tet families with some symbol changes and new sequences added; A description and explanation are included below - Some van genes were moved to the plus category, see below for an explanation - Class and subclass and protein names were changed for several blaOXA and blaKPC alleles to reflect new information about their function - We removed some HMMs that are not specific to AMR genes and have no effect on which proteins are reported - Organism names were changed to match some GenBank records - PubMed references added to 1,591 AMR genes in the Reference Gene Catalog. In the interest of clarity those additions are not listed below Additional details: Pencillin-resistant Streptococcus pneumoniae pbp alleles are defined as those alleles which are below a protein identity threshold to a set of pbp1a, pbp2b, or pbp2x reference alleles: the thresholds are 99%, 99%, and 98% for pbp1a, pbp2b, and pbp2x respectively. The susceptible reference alleles can be found in NCBI's Reference Gene Catalog. These alleles may also confer resistance to other beta-lactam antibiotics. If you are using AMRFinderPlus with Streptococcus pneumoniae pbp genes you may need to analyze further as necessary. In the future Streptococcus pneumoniae will be added to MicroBIGG-E and you will be able to download the sequence of the variant alleles there. Some DfrA protein families were renamed or newly created, guided by advice from Dr. Ruth Hall, after observation of accidental use of the same designations by different groups for different proteins. For those DfrA proteins encoded within integrons, NCBI recognizes that families can be defined narrowly, as sets of proteins sharing 98% or more amino acid sequence identity, as that follows common practice in the literature. In general, NCBI follows the nomenclature maintained by Dr. Marilyn Roberts for the naming of all tetracycline resistance (Tet) protein families, including the tetracycline-inactivating monooxygenase Tet(X). However, in response to a growing literature showing interest in subfamilies within the Tet(X) family, we now provide assignments for subfamilies of Tet(X) with designations up through Tet(X5), following Chen, et al. (PMID:33287863). Note that these designations refer to subfamilies, not alleles. Designations beyond Tet(X5) that appear in the literature probably should be considered provisional and subject to change. We also now recognize several mosaic forms of tet genes related to tet(W) and tet(O). Five Van genes were moved from core to plus. These are genes that are found exclusively in Clostridioides difficile, and, by themselves, do not confer vancomycin resistance. Because they are found in most C. difficile, they have been moved to plus since they are non-determinative for phenotype. Note that listed below are sequences that were removed, generally these are incorrect and replaced by corrected proteins. Summary: Total proteins: 6650 Core proteins: 5760 Plus proteins: 890 AMR proteins: 5800 STRESS proteins: 211 VIRULENCE proteins: 639 Point mutations: 728 Point mutation references: 104 Point mutation organism groups: Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 630 Updates since release 2020-12-17.1: Proteins added: 72 Core proteins added: 71 Plus proteins added: 1 AMR proteins added: 71 VIRULENCE proteins added: 1 Alleles added: 34 Point mutations added: 15 Proteins removed: 2 Core proteins removed: 2 Plus proteins removed: 0 Point mutations removed 12 Reference Gene Catalog entries changed: 40 Families added: 31 Families removed: 2 Families changed: 8 Added proteins core AMR AMR dfrA4 NG_073445.1 WP_011977799.1 trimethoprim-resistant dihydrofolate reductase DfrA4 tet(O/W/32/O) NG_073452.1 WP_013646121.1 tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O) fosM2 NG_073449.1 WP_066187568.1 fosfomycin resistance protein FosM2 fosM1 NG_073448.1 WP_102272729.1 fosfomycin resistance protein FosM1 tet(X5) NG_073455.1 WP_150378267.1 tetracycline-inactivating monooxygenase Tet(X5) dfrA48 NG_073572.1 WP_173288987.1 trimethoprim-resistant dihydrofolate reductase DfrA48 tet(O/W) NG_073451.1 WP_204313008.1 tetracycline resistance ribosomal protection mosaic protein Tet(O/W) tet(W/32/O) NG_073453.1 WP_204313011.1 tetracycline resistance ribosomal protection mosaic protein Tet(W/32/O) dfrA25 NG_065841.2 WP_204376219.1 trimethoprim-resistant dihydrofolate reductase DfrA25 dfrA44 NG_073446.1 WP_204376220.1 trimethoprim-resistant dihydrofolate reductase DfrA44 fosM3 NG_073450.1 WP_204376221.1 fosfomycin resistance protein FosM3 tet(X1) NG_073454.1 WP_204376222.1 tetracycline-inactivating monooxygenase Tet(X1) blaADC-256 NG_073457.1 WP_204376223.1 class C beta-lactamase ADC-256 blaAFM-2 NG_073458.1 WP_204376224.1 subclass B1 metallo-beta-lactamase AFM-2 blaCMY-174 NG_073459.1 WP_200302238.1 class C beta-lactamase CMY-174 blaCTX-M-244 NG_073460.1 WP_204376225.1 class A extended-spectrum beta-lactamase CTX-M-244 blaEBR-4 NG_073461.1 WP_114999921.1 subclass B1 metallo-beta-lactamase EBR-4 blaFRI-10 NG_073462.1 WP_204376226.1 carbapenem-hydrolyzing class A beta-lactamase FRI-10 blaGMB-1 NG_073463.1 WP_204376227.1 subclass B1 metallo-beta-lactamase GMB-1 blaIMI-21 NG_073464.1 WP_204376228.1 carbapenem-hydrolyzing class A beta-lactamase IMI-21 blaKPC-62 NG_073465.1 WP_204376229.1 class A beta-lactamase KPC-62 blaKPC-63 NG_073466.1 WP_204376230.1 class A beta-lactamase KPC-63 blaKPC-64 NG_073467.1 WP_204376231.1 class A beta-lactamase KPC-64 blaKPC-65 NG_073468.1 WP_204376232.1 class A beta-lactamase KPC-65 blaKPC-80 NG_073469.1 WP_204376233.1 carbapenem-hydrolyzing class A beta-lactamase KPC-80 blaKPC-81 NG_073470.1 WP_204376234.1 carbapenem-hydrolyzing class A beta-lactamase KPC-81 blaKPC-82 NG_073471.1 WP_202781289.1 inhibitor-resistant class A beta-lactamase KPC-82 blaOXA-927 NG_073472.1 WP_047480628.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-927 blaOXA-945 NG_073473.1 WP_204376235.1 OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-945 blaOXA-946 NG_073474.1 WP_204376236.1 OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-946 blaOXA-947 NG_073475.1 WP_204376237.1 OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-947 blaOXA-948 NG_073476.1 WP_204376238.1 OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-948 blaOXA-949 NG_073477.1 WP_204376239.1 OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-949 blaPDC-467 NG_073478.1 WP_204376240.1 class C beta-lactamase PDC-467 blaPDC-468 NG_073479.1 WP_204376241.1 class C beta-lactamase PDC-468 blaPDC-469 NG_073480.1 WP_204376242.1 class C beta-lactamase PDC-469 blaPDC-470 NG_073481.1 WP_204376243.1 class C beta-lactamase PDC-470 blaPDC-471 NG_073482.1 WP_204376244.1 class C beta-lactamase PDC-471 blaPDC-472 NG_073483.1 WP_204376245.1 class C beta-lactamase PDC-472 blaPDC-473 NG_073489.1 WP_204378708.1 class C beta-lactamase PDC-473 blaPDC-474 NG_073490.1 WP_204378709.1 class C beta-lactamase PDC-474 blaPDC-475 NG_073491.1 WP_204378710.1 class C beta-lactamase PDC-475 blaPDC-476 NG_073492.1 WP_204378711.1 class C beta-lactamase PDC-476 blaPER-16 NG_073484.1 WP_202089433.1 class A extended-spectrum beta-lactamase PER-16 fosU1 NG_073485.1 WP_204376246.1 fosfomycin resistance glutathione transferase FosU1 fosU2 NG_073486.1 WP_204376247.1 fosfomycin resistance glutathione transferase FosU2 core AMR AMR-SUSCEPTIBLE pbp2x ALCO01000001.1 EJH07906.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp2x MLGJ01000011.1 OIB10928.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp2x JAAAQR010000224.1 NMG91507.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp2x CP002121.1 ADM83960.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp2x CNXL02000011.1 CTF03593.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp2x AE005672.3 AAK74511.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp2x UHGH01000001.1 SUO05487.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp2x UYIP01000001.1 VDG79030.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp1a WNHU01000041.1 MTV43544.1 Streptococcus pneumoniae beta-lactam resistant Pbp1a pbp1a UHGV01000002.1 SUO36701.1 Streptococcus pneumoniae beta-lactam resistant Pbp1a pbp1a CP002121.1 ADM83986.1 Streptococcus pneumoniae beta-lactam resistant Pbp1a pbp1a AE005672.3 AAK74536.1 Streptococcus pneumoniae beta-lactam resistant Pbp1a pbp2b UHGI01000001.1 SUO08321.1 Streptococcus pneumoniae beta-lactam resistant Pbp2b pbp2b FQ312027.1 CBW33123.1 Streptococcus pneumoniae beta-lactam resistant Pbp2b pbp2b ALAW01000018.1 EJG35019.1 Streptococcus pneumoniae beta-lactam resistant Pbp2b pbp2b CP002121.1 ADM85262.1 Streptococcus pneumoniae beta-lactam resistant Pbp2b pbp2b FFQV01000008.1 CXF06025.1 Streptococcus pneumoniae beta-lactam resistant Pbp2b pbp2x LJMO01000139.1 KYA87151.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp1a UHGB01000001.1 SUN90660.1 Streptococcus pneumoniae beta-lactam resistant Pbp1a pbp1a UHFY01000001.1 SUN89985.1 Streptococcus pneumoniae beta-lactam resistant Pbp1a pbp2x LWGW01000042.1 OCQ83618.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp2x CNPV02000129.1 CTH70606.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x pbp1a CNZD02000033.1 CTN64071.1 Streptococcus pneumoniae beta-lactam resistant Pbp1a pbp2b FHTX02000001.1 VJH99099.1 Streptococcus pneumoniae beta-lactam resistant Pbp2b pbp2x FHSK02000014.1 VMM09393.1 Streptococcus pneumoniae beta-lactam resistant Pbp2x plus VIRULENCE VIRULENCE cdtB AL513382.1 CAD02120.1 cytolethal distending toxin S-CDT Added point mutations core AMR POINT grlA_D84G QUINOLONE Staphylococcus_pseudintermedius grlA_D84H QUINOLONE Staphylococcus_pseudintermedius grlA_D84N QUINOLONE Staphylococcus_pseudintermedius grlA_D84Y QUINOLONE Staphylococcus_pseudintermedius grlA_S80I QUINOLONE Staphylococcus_pseudintermedius grlA_S80R QUINOLONE Staphylococcus_pseudintermedius gyrA_E88G QUINOLONE Staphylococcus_pseudintermedius gyrA_E88K QUINOLONE Staphylococcus_pseudintermedius gyrA_S84A QUINOLONE Staphylococcus_pseudintermedius gyrA_S84L QUINOLONE Staphylococcus_pseudintermedius gyrA_S84W QUINOLONE Staphylococcus_pseudintermedius gyrA_S85A QUINOLONE Staphylococcus_pseudintermedius rpoB_A473AA RIFAMPIN Staphylococcus_pseudintermedius rpoB_H481Y RIFAMPIN Staphylococcus_pseudintermedius rpoB_S486L RIFAMPIN Staphylococcus_pseudintermedius Removed proteins core AMR AMR dfrA29 NG_065841.1 WP_148044403.1 trimethoprim-resistant dihydrofolate reductase DfrA29 mcr-3.30 NG_065456.1 WP_140423332.1 phosphoethanolamine--lipid A transferase MCR-3.30 Proteins reclassified from 'core' to 'plus' vanR-Cd NG_061618.1 WP_003436401.1 VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR vanZ1 NG_061614.1 WP_009889012.1 glycopeptide resistance protein VanZ1 vanS-Cd NG_061619.1 WP_011861275.1 VanG-Cd-type vancomycin resistance histidine kinase VanS vanG NG_061616.1 WP_011861276.1 D-alanine--D-serine ligase VanG-Cd vanT-Cd NG_052046.1 WP_071593222.1 membrane-bound serine racemase VanT-Cd Removed point mutations core AMR POINT pbp1a_N609D BETA-LACTAM Streptococcus_pneumoniae pbp1a_S575T BETA-LACTAM Streptococcus_pneumoniae pbp1a_T371S BETA-LACTAM Streptococcus_pneumoniae pbp2b_E476G BETA-LACTAM Streptococcus_pneumoniae pbp2b_T446A BETA-LACTAM Streptococcus_pneumoniae pbp2b_T489A BETA-LACTAM Streptococcus_pneumoniae pbp2x_I371T BETA-LACTAM Streptococcus_pneumoniae pbp2x_L546V BETA-LACTAM Streptococcus_pneumoniae pbp2x_M339T BETA-LACTAM Streptococcus_pneumoniae pbp2x_M400T BETA-LACTAM Streptococcus_pneumoniae pbp2x_N514H BETA-LACTAM Streptococcus_pneumoniae pbp2x_N605T BETA-LACTAM Streptococcus_pneumoniae Changed reference gene catalog records dfrA27 WP_001749985.1 allele: dfrA27 -> gene_family: dfrA -> dfrA27 tet(O/M/O) WP_002872163.1 gene_family: tet(O) -> tet(O/M/O) product_name: tetracycline resistance ribosomal protection protein Tet(O) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/M/O) fosX WP_003726635.1 product_name: fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX dfrA21 WP_004187529.1 allele: dfrA21 -> gene_family: dfrA -> dfrA21 tet(X2) WP_008651082.1 gene_family: tet(X) -> tet(X2) product_name: tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2) fosX WP_010989789.1 product_name: fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX fosI WP_014714131.1 allele: fosI -> gene_family: fosX -> fosI product_name: fosfomycin resistance thiol transferase FosI -> fosfomycin resistance hydrolase FosI tet(X2) WP_015060600.1 gene_family: tet(X) -> tet(X2) product_name: tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2) tet(X3) WP_015060917.1 gene_family: tet(X) -> tet(X3) product_name: tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X3) tet(O/32/O) WP_015573056.1 gene_family: tet(32) -> tet(O/32/O) product_name: tetracycline resistance ribosomal protection protein Tet(32) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/32/O) fosX WP_015860243.1 product_name: FosX/FosE/FosI family fosfomycin resistance thiol transferase -> FosX/FosE/FosI family fosfomycin resistance hydrolase tet(X3) WP_024160783.1 gene_family: tet(X) -> tet(X3) product_name: tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X3) tet(W/N/W) WP_024963478.1 gene_family: tet(W) -> tet(W/N/W) product_name: tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W) dfrA32 WP_032084013.1 allele: dfrA32 -> gene_family: dfrA -> dfrA32 dfrA47 WP_034072810.1 gene_family: dfrA22 -> dfrA47 product_name: trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA47 dfrA29 WP_045899678.1 gene_family: dfr7 -> dfrA29 product_name: trimethoprim-resistant dihydrofolate reductase Dfr7 -> trimethoprim-resistant dihydrofolate reductase DfrA29 tet(O/W/O) WP_054336482.1 gene_family: tet(W) -> tet(O/W/O) product_name: tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O) fosE WP_054882068.1 product_name: fosfomycin resistance thiol transferase FosE -> fosfomycin resistance hydrolase FosE dfrA33 WP_063844371.1 gene_family: dfrA22 -> dfrA33 product_name: trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA33 dfrA46 WP_063844461.1 gene_family: dfrA6 -> dfrA46 product_name: trimethoprim-resistant dihydrofolate reductase DfrA6 -> trimethoprim-resistant dihydrofolate reductase DfrA46 tet(O/W/32/O) WP_063856419.1 gene_family: tet(W) -> tet(O/W/32/O) product_name: tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O) tet(O/W/32/O) WP_063856420.1 gene_family: tet(W) -> tet(O/W/32/O) product_name: tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O) tet(O/W/O) WP_063856421.1 gene_family: tet(W) -> tet(O/W/O) product_name: tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O) tet(X2) WP_063856436.1 gene_family: tet(X) -> tet(X2) product_name: tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2) tet(X5) WP_063856444.1 gene_family: tet(X) -> tet(X5) product_name: tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X5) dfrA33 WP_071846242.1 gene_family: dfrA22 -> dfrA33 product_name: trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA33 tet(X4) WP_094309310.1 gene_family: tet(X) -> tet(X4) product_name: tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X4) tet(W/N/W) WP_122634437.1 gene_family: tet(W) -> tet(W/N/W) product_name: tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W) blaADC-8 WP_004923134.1 product_name: cephalosporin-hydrolyzing class C beta-lactamase ADC-8 -> ADC-like class C beta-lactamase ADC-8 blaCTX-M-151 WP_063859960.1 product_name: class A extended-spectrum beta-lactamase CTX-M-151 -> CTX-M-like class A extended-spectrum beta-lactamase CTX-M-151 blaKPC-53 WP_156649232.1 product_name: carbapenem-hydrolyzing class A beta-lactamase KPC-53 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-53 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-66 WP_188331871.1 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-72 WP_188331872.1 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-73 WP_188331873.1 subclass: CARBAPENEM -> CEPHALOSPORIN blaKPC-79 WP_197749404.1 product_name: class A beta-lactamase KPC-79 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-79 subclass: CARBAPENEM -> CEPHALOSPORIN blaOXA-427 WP_096807440.1 product_name: class D beta-lactamase OXA-427 -> carbapenem-hydrolyzing class D beta-lactamase OXA-427 blaOXA-679 WP_122634439.1 product_name: OXA-667 family class D beta-lactamase OXA-679 -> carbapenem-hydrolyzing class D beta-lactamase OXA-679 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-730 WP_116786836.1 product_name: class D beta-lactamase OXA-730 -> OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-730 subclass: BETA-LACTAM -> CARBAPENEM blaOXA-917 WP_161507793.1 product_name: class D beta-lactamase OXA-917 -> carbapenem-hydrolyzing class D beta-lactamase OXA-917 fosH WP_063851233.1 product_name: fosfomycin resistance thiol transferase FosH -> fosfomycin resistance hydrolase FosH Added families cdtB - cytolethal distending toxin S-CDT blaGMB NF038103.1 GMB family subclass B1 metallo-beta-lactamase blaOXA NF038333.1 blaOXA-679 family carbapenem-hydrolyzing class D beta-lactamase dfrA - DfrA12/DfrA21 family trimethoprim-resistant dihydrofolate reductase dfrA21 - trimethoprim-resistant dihydrofolate reductase DfrA21 dfrA27 - trimethoprim-resistant dihydrofolate reductase DfrA27 dfrA32 - trimethoprim-resistant dihydrofolate reductase DfrA32 dfrA33 - trimethoprim-resistant dihydrofolate reductase DfrA33 dfrA4 - trimethoprim-resistant dihydrofolate reductase DfrA4 dfrA44 - trimethoprim-resistant dihydrofolate reductase DfrA44 dfrA46 - trimethoprim-resistant dihydrofolate reductase DfrA46 dfrA47 - trimethoprim-resistant dihydrofolate reductase DfrA47 dfrA48 - trimethoprim-resistant dihydrofolate reductase DfrA48 fosI - fosfomycin resistance hydrolase FosI fosM NF038306.1 FosM family fosfomycin resistance protein fosM1 - fosfomycin resistance protein FosM1 fosM2 - fosfomycin resistance protein FosM2 fosM3 - fosfomycin resistance protein FosM3 fosU NF038311.1 FosU family fosfomycin resistance glutathione transferase tet(O/32/O) - tetracycline resistance ribosomal protection mosaic protein Tet(O/32/O) tet(O/M/O) - tetracycline resistance ribosomal protection mosaic protein Tet(O/M/O) tet(O/W) - tetracycline resistance ribosomal protection mosaic protein Tet(O/W) tet(O/W/32/O) - tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O) tet(O/W/O) - tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O) tet(W/32/O) - tetracycline resistance ribosomal protection mosaic protein Tet(W/32/O) tet(W/N/W) - tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W) tet(X1) - tetracycline-inactivating monooxygenase Tet(X1) tet(X2) - tetracycline-inactivating monooxygenase Tet(X2) tet(X3) - tetracycline-inactivating monooxygenase Tet(X3) tet(X4) - tetracycline-inactivating monooxygenase Tet(X4) tet(X5) - tetracycline-inactivating monooxygenase Tet(X5) Removed families dfr7 - trimethoprim-resistant dihydrofolate reductase Dfr7 dfrA NF000055.3 DfrA13/DfrA21 family trimethoprim-resistant dihydrofolate reductase Family changes - multidrug efflux RND transporter permease subunit hmm_id: NF000282.2 -> - adeC AdeC/AdeK/OprM family multidrug efflux complex outer membrane factor hmm_id: NF000315.1 -> - blaADC ADC-like cephalosporin-hydrolyzing class C beta-lactamase family_name: ADC-8-like cephalosporin-hydrolyzing class C beta-lactamase -> ADC-like cephalosporin-hydrolyzing class C beta-lactamase fosE fosfomycin resistance hydrolase FosE family_name: fosfomycin resistance thiol transferase FosE -> fosfomycin resistance hydrolase FosE fosX fosfomycin resistance hydrolase FosX family_name: fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX fosX FosX/FosE/FosI family fosfomycin resistance hydrolase family_name: FosX/FosE/FosI family fosfomycin resistance thiol transferase -> FosX/FosE/FosI family fosfomycin resistance hydrolase mexX MexX/AmrA family multidrug efflux RND transporter periplasmic adaptor subunit hmm_id: NF000252.1 -> - - phosphoethanolamine--lipid A transferase hmm_id: NF028537.1 -> - ---------------------------------------------------------------------- Changes included in 2020-12-17.1 ---------------------------------------------------------------------- Highlights: - Changed eae from subclass ANTIGEN to subclass VIRULENCE - Some recategorization of eae genes - Hybrid gene symbols added to fusion genes in the reference gene catalog (e.g., aac(6')-Ie/aph(2'')-Ia) - Many new beta-lactamase alleles especially blaADCs and blaOXAs - Some new Staphylococcus virulence gene families Summary: Total proteins: 6580 Core proteins: 5696 Plus proteins: 884 AMR proteins: 5731 STRESS proteins: 211 VIRULENCE proteins: 638 Point mutations: 725 Point mutation references: 104 Point mutation organism groups: Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 631 Updates since release 2020-11-09.1: Proteins added: 61 Core proteins added: 56 Plus proteins added: 5 AMR proteins added: 56 VIRULENCE proteins added: 5 Alleles added: 49 Reference Gene Catalog entries changed: 82 Families added: 11 Families removed: 1 Families changed: 8 Added proteins core AMR AMR dfrA42 NG_071176.1 WP_045475347.1 trimethoprim-resistant dihydrofolate reductase DfrA42 tet(63) NG_071181.1 WP_050437591.1 tetracycline efflux MFS transporter Tet(63) msr(G) NG_071179.1 WP_101035417.1 ABC-F type ribosomal protection protein Msr(G) tet(64) NG_071182.1 WP_124470450.1 tetracycline efflux MFS transporter Tet(64) lsa(D) NG_071178.1 WP_165713684.1 ABC-F type ribosomal protection protein Lsa(D) dfrA38 NG_071175.1 WP_197749399.1 trimethoprim-resistant dihydrofolate reductase DfrA38 tet(62) NG_071180.1 WP_197749400.1 tetracycline efflux MFS transporter Tet(62) blaADC-237 NG_071183.1 WP_086262823.1 class C beta-lactamase ADC-237 blaADC-238 NG_071184.1 WP_002058891.1 class C beta-lactamase ADC-238 blaADC-239 NG_071185.1 WP_031981814.1 class C beta-lactamase ADC-239 blaADC-240 NG_071186.1 WP_001211207.1 class C beta-lactamase ADC-240 blaADC-241 NG_071187.1 WP_001211198.1 class C beta-lactamase ADC-241 blaADC-242 NG_071188.1 WP_047481394.1 class C beta-lactamase ADC-242 blaADC-243 NG_071189.1 WP_001211199.1 class C beta-lactamase ADC-243 blaADC-244 NG_071190.1 WP_032017586.1 class C beta-lactamase ADC-244 blaADC-245 NG_071191.1 WP_032005249.1 class C beta-lactamase ADC-245 blaADC-246 NG_071192.1 WP_031976577.1 class C beta-lactamase ADC-246 blaADC-247 NG_071193.1 WP_032058755.1 class C beta-lactamase ADC-247 blaADC-248 NG_071194.1 WP_021511005.1 class C beta-lactamase ADC-248 blaADC-249 NG_071195.1 WP_001211200.1 class C beta-lactamase ADC-249 blaADC-250 NG_071196.1 WP_086329657.1 class C beta-lactamase ADC-250 blaADC-251 NG_071197.1 WP_086443396.1 class C beta-lactamase ADC-251 blaADC-252 NG_071198.1 WP_086399847.1 class C beta-lactamase ADC-252 blaADC-253 NG_071199.1 WP_086394244.1 class C beta-lactamase ADC-253 blaADC-254 NG_071200.1 WP_031996777.1 class C beta-lactamase ADC-254 blaADC-255 NG_071201.1 WP_022575343.1 class C beta-lactamase ADC-255 blaGES-46 NG_071202.1 WP_197749401.1 class A beta-lactamase GES-46 blaKPC-49 NG_071203.1 WP_197749402.1 carbapenem-hydrolyzing class A beta-lactamase KPC-49 blaKPC-78 NG_071204.1 WP_197749403.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-78 blaKPC-79 NG_071205.1 WP_197749404.1 class A beta-lactamase KPC-79 blaNDM-30 NG_071206.1 WP_197749405.1 subclass B1 metallo-beta-lactamase NDM-30 blaNDM-31 NG_071207.1 WP_197749406.1 subclass B1 metallo-beta-lactamase NDM-31 blaOXA-936 NG_071208.1 WP_004641493.1 OXA-214 family carbapenem-hydrolyzing class D beta-lactamase OXA-936 blaOXA-937 NG_071209.1 WP_034081711.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-937 blaOXA-938 NG_071210.1 WP_086263559.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-938 blaOXA-939 NG_071211.1 WP_086261538.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-939 blaOXA-940 NG_071212.1 WP_086442870.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-940 blaOXA-941 NG_071213.1 WP_086395021.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-941 blaOXA-942 NG_071214.1 WP_078225401.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-942 blaOXA-943 NG_071215.1 WP_086398931.1 OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-943 blaPDC-458 NG_071216.1 WP_197749407.1 class C beta-lactamase PDC-458 blaPDC-459 NG_071217.1 WP_197749408.1 class C beta-lactamase PDC-459 blaPDC-460 NG_071218.1 WP_197749409.1 class C beta-lactamase PDC-460 blaPDC-461 NG_071219.1 WP_197749410.1 class C beta-lactamase PDC-461 blaPDC-462 NG_071220.1 WP_197749411.1 class C beta-lactamase PDC-462 blaPDC-463 NG_071221.1 WP_197749412.1 class C beta-lactamase PDC-463 blaPDC-464 NG_071222.1 WP_197749413.1 class C beta-lactamase PDC-464 blaPDC-465 NG_071223.1 WP_197749414.1 class C beta-lactamase PDC-465 blaPDC-466 NG_071224.1 WP_197749415.1 class C beta-lactamase PDC-466 blaTEM-103 NG_071225.1 WP_094353585.1 inhibitor-resistant class A broad-spectrum beta-lactamase TEM-103 blaTEM-243 NG_071226.1 WP_197749416.1 class A beta-lactamase TEM-243 cfiA26 NG_071227.1 WP_197749417.1 subclass B1 metallo-beta-lactamase CfiA26 cfiA27 NG_071228.1 WP_197749418.1 subclass B1 metallo-beta-lactamase CfiA27 cfiA28 NG_071229.1 WP_193683783.1 subclass B1 metallo-beta-lactamase CfiA28 mcr-3.41 NG_071230.1 WP_181497495.1 phosphoethanolamine--lipid A transferase MCR-3.41 qnrB93 NG_071231.1 WP_174771641.1 quinolone resistance pentapeptide repeat protein QnrB93 plus VIRULENCE VIRULENCE hld AF068634.1 AAC21574.1 delta-hemolysin hld CP003979.1 AGU62139.1 delta-hemolysin lukE Y13225.1 CAA73667.1 bi-component leukocidin LukED subunit E aur AHJW01000015.1 EHO93748.1 zinc metalloproteinase aureolysin lukE MSGQ01000028.1 RCV70079.1 bi-component leukocidin LukED subunit E Changed reference gene catalog records eae AAF23359.1 subtype: ANTIGEN -> VIRULENCE eae ABF69110.1 product_name: intimin type beta -> intimin type kappa subclass: BETA -> KAPPA subtype: ANTIGEN -> VIRULENCE eae ABF69117.1 product_name: intimin type epsilon -> intimin type xi subclass: EPSILON -> XI subtype: ANTIGEN -> VIRULENCE eae ABF69121.1 subtype: ANTIGEN -> VIRULENCE eae ABF69122.1 product_name: intimin type alpha -> intimin type nu subclass: ALPHA -> NU subtype: ANTIGEN -> VIRULENCE eae ABQ02454.1 subtype: ANTIGEN -> VIRULENCE eae ACM67143.1 subtype: ANTIGEN -> VIRULENCE eae ACM67145.1 subtype: ANTIGEN -> VIRULENCE eae ACM67146.1 subtype: ANTIGEN -> VIRULENCE eae ACM67148.1 subtype: ANTIGEN -> VIRULENCE eae ACM67149.1 subtype: ANTIGEN -> VIRULENCE eae ACM67152.1 subtype: ANTIGEN -> VIRULENCE eae ACM67153.1 subtype: ANTIGEN -> VIRULENCE eae ACM67154.1 subtype: ANTIGEN -> VIRULENCE eae ACM67155.1 subtype: ANTIGEN -> VIRULENCE eae ACM67156.1 subtype: ANTIGEN -> VIRULENCE eae ACM67157.1 subtype: ANTIGEN -> VIRULENCE eae ACM67158.1 subtype: ANTIGEN -> VIRULENCE eae ACM67160.1 subtype: ANTIGEN -> VIRULENCE eae ACM67161.1 subtype: ANTIGEN -> VIRULENCE eae ACM67162.1 subtype: ANTIGEN -> VIRULENCE eae ACM67163.1 subtype: ANTIGEN -> VIRULENCE eae ACM67164.1 subtype: ANTIGEN -> VIRULENCE eae ACM67165.1 subtype: ANTIGEN -> VIRULENCE eae ACM67166.1 subtype: ANTIGEN -> VIRULENCE eae ACM67167.1 subtype: ANTIGEN -> VIRULENCE eae ACM67168.1 subtype: ANTIGEN -> VIRULENCE eae ACM67169.1 subtype: ANTIGEN -> VIRULENCE eae ACM67172.1 subtype: ANTIGEN -> VIRULENCE eae ACM67177.1 subtype: ANTIGEN -> VIRULENCE eae ACM67178.1 subtype: ANTIGEN -> VIRULENCE eae ADD58881.1 subtype: ANTIGEN -> VIRULENCE eae BAL46940.1 subtype: ANTIGEN -> VIRULENCE eae BAL46941.1 subtype: ANTIGEN -> VIRULENCE eae BAL47132.1 subtype: ANTIGEN -> VIRULENCE eae BAL47176.1 product_name: intimin type rho -> intimin type ypsilon subclass: RHO -> YPSILON subtype: ANTIGEN -> VIRULENCE eae BAL47179.1 subtype: ANTIGEN -> VIRULENCE eae BAL47181.1 subtype: ANTIGEN -> VIRULENCE eae BAT41861.1 subtype: ANTIGEN -> VIRULENCE eae CAI43865.1 subtype: ANTIGEN -> VIRULENCE eae CAS06720.1 product_name: intimin type gamma -> intimin type theta subclass: GAMMA -> THETA subtype: ANTIGEN -> VIRULENCE eae CAS06721.1 product_name: intimin type alpha -> intimin type zeta subclass: ALPHA -> ZETA subtype: ANTIGEN -> VIRULENCE eae CAS06723.1 product_name: intimin type alpha -> intimin type zeta subclass: ALPHA -> ZETA subtype: ANTIGEN -> VIRULENCE mef(A) WP_000417517.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_000417519.1 subclass: MACROLIDE -> ERYTHROMYCIN msr(D) WP_000420313.1 subclass: MACROLIDE -> ERYTHROMYCIN msr(D) WP_000420317.1 subclass: MACROLIDE -> ERYTHROMYCIN aac(6')-Ie/aph(2'')-Ia WP_001028144.1 gene_family: -> aac(6')-Ie/aph(2'')-Ia mef(A) WP_012102963.1 subclass: MACROLIDE -> ERYTHROMYCIN aac(6')-Ie/aph(2'')-Ia WP_012655884.1 gene_family: -> aac(6')-Ie/aph(2'')-Ia mef(A) WP_014636304.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_018374806.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_024127829.1 subclass: MACROLIDE -> ERYTHROMYCIN aac(6')-Ie/aph(2'')-Ia WP_032490744.1 gene_family: -> aac(6')-Ie/aph(2'')-Ia aac(6')-Ie/aph(2'')-If2 WP_057097547.1 gene_family: -> aac(6')-Ie/aph(2'')-If2 mef(A) WP_058621816.1 subclass: MACROLIDE -> ERYTHROMYCIN aac(3)-Ib/aac(6')-Ib'' WP_063838852.1 gene_family: -> aac(3)-Ib/aac(6')-Ib'' aac(6')-30/aac(6')-Ib' WP_063838853.1 gene_family: -> aac(6')-30/aac(6')-Ib' ant(3'')-Ij/aac(6')-Ib WP_063839875.1 gene_family: -> ant(3'')-Ij/aac(6')-Ib blaOXA/blaLRA13 WP_063839877.1 gene_family: -> blaOXA/blaLRA13 ant(3'')-Ih/aac(6')-IId WP_063839878.1 gene_family: -> ant(3'')-Ih/aac(6')-IId mef(A) WP_063853554.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853563.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853574.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853591.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853602.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853625.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853632.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853638.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853648.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853682.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853689.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853698.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853705.1 subclass: MACROLIDE -> ERYTHROMYCIN mef(A) WP_063853713.1 subclass: MACROLIDE -> ERYTHROMYCIN ant(3'')-Ij/aac(6')-IIa WP_070342373.1 gene_family: -> ant(3'')-Ij/aac(6')-IIa catB8/aac(6')-Ib' WP_071593228.1 gene_family: -> catB8/aac(6')-Ib' estX/sat2 WP_071846307.1 gene_family: -> estX/sat2 aac(6')-Ie/aph(2'') WP_122630840.1 gene_family: -> aac(6')-Ie/aph(2'') dfrA43 WP_188331861.1 genbank_cds_start: 409 -> 6965 genbank_cds_stop: 996 -> 7552 genbank_nucleotide_accession: HQ386844.1 -> HQ386844.2 gene_family: dfrA38 -> dfrA43 product_name: trimethoprim-resistant dihydrofolate reductase DfrA38 -> trimethoprim-resistant dihydrofolate reductase DfrA43 blaCARB-55 WP_071846358.1 allele: -> blaCARB-55 product_name: PSE family carbenicillin-hydrolyzing class A beta-lactamase -> PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-55 blaOXA-917 WP_161507793.1 subclass: BETA-LACTAM -> CARBAPENEM Added families aur - zinc metalloproteinase aureolysin blaOXA NF038217.1 OXA-427 family carbapenem-hydrolyzing class D beta-lactamase dfrA42 - trimethoprim-resistant dihydrofolate reductase DfrA42 dfrA43 - trimethoprim-resistant dihydrofolate reductase DfrA43 hld - delta-hemolysin lsa(D) - ABC-F type ribosomal protection protein Lsa(D) lukE - bi-component leukocidin LukED subunit E msr(G) - ABC-F type ribosomal protection protein Msr(G) tet(62) - tetracycline efflux MFS transporter Tet(62) tet(63) - tetracycline efflux MFS transporter Tet(63) tet(64) - tetracycline efflux MFS transporter Tet(64) Removed families - - Family changes eae intimin type nu family_name: intimin type alpha -> intimin type nu eae intimin type zeta family_name: intimin type alpha -> intimin type zeta eae intimin type kappa family_name: intimin type beta -> intimin type kappa blaBUT BUT family class C beta-lactamase hmm_id: - -> NF038238.1 eae intimin type xi family_name: intimin type epsilon -> intimin type xi eae intimin type theta family_name: intimin type gamma -> intimin type theta gar_fam garosamine-type aminoglycoside resistance ATP-binding protein hmm_id: - -> NF038208.1 eae intimin type ypsilon family_name: intimin type rho -> intimin type ypsilon ---------------------------------------------------------------------- Changes included in 2020-11-09.1 ---------------------------------------------------------------------- This release includes a change to the database format. It is compatible with AMRFinderPlus versions in the 3.9 series. You will need to upgrade your software to version 3.9 to use this database. The database format change was necessitated by two changes in functionality. (1) Alleles may now have different classes and subclasses from their parent node. (2) The blaEC family was moved to "plus", while specific alleles remain reportable in the "core" set. Other changes: - Point mutations for Acenitobacter baumannii, Streptococcus_pneumoniae, and Streptococcus pyogenes were added - A few families of plus AMR genes where presence/absence is not likely to impact phenotype were removed - New core AMR families cml, gar, grdA - Updates to provide more specific phenotype information for a few genes - The usual new alleles of existing families Note: It has come to our attention that the gene symbol for dfrA38 may conflict with a publication. We are attempting to resolve the issue, so the symbol dfrA38 may change. Summary: Total proteins: 6519 Core proteins: 5640 Plus proteins: 879 AMR proteins: 5675 STRESS proteins: 211 VIRULENCE proteins: 633 Point mutations: 725 Point mutation references: 104 Point mutation organism groups: Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes HMMs: 628 Updates since release 2020-09-30.1: Proteins added: 23 Core proteins added: 18 Plus proteins added: 2 AMR proteins added: 18 VIRULENCE proteins added: 2 Alleles added: 55 Point mutations added: 43 Protiens removed: 4 Core proteins removed: 0 Plus proteins removed: 4 Reference Gene Catalog entries changed: 4 Families added: 12 Families removed: 4 Families changed: 3 Added proteins core AMR AMR cml NG_070887.1 WP_011552636.1 Cml family chloramphenicol efflux MFS transporter grdA NG_070892.1 WP_052905207.1 gentamicin resistance ATP-binding protein GrdA cml NG_070888.1 WP_061345584.1 Cml family chloramphenicol efflux MFS transporter cml NG_070889.1 WP_115421099.1 Cml family chloramphenicol efflux MFS transporter gar NG_070891.1 WP_162615879.1 gentamicin resistance ATP-binding protein Gar gar NG_070890.1 WP_194293131.1 gentamicin resistance ATP-binding protein Gar blaAAK-1 NG_070893.1 WP_194293132.1 class A beta-lactamase AAK-1 blaCMY-173 NG_070783.1 WP_190259774.1 class C beta-lactamase CMY-173 blaCTX-M-242 NG_070784.1 WP_190259775.1 class A extended-spectrum beta-lactamase CTX-M-242 blaIMI-20 NG_070894.1 WP_194293133.1 carbapenem-hydrolyzing class A beta-lactamase IMI-20 blaKPC-71 NG_070895.1 WP_194293134.1 inhibitor-resistant class A beta-lactamase KPC-71 blaKPC-76 NG_070896.1 WP_194293135.1 class A beta-lactamase KPC-76 blaKPC-77 NG_070897.1 WP_194293136.1 carbapenem-hydrolyzing class A beta-lactamase KPC-77 blaOXA-893 NG_070898.1 WP_194293137.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-893 blaOXA-930 NG_070785.1 WP_151781119.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-930 blaOXA-931 NG_070786.1 WP_190259776.1 OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-931 blaOXA-932 NG_070899.1 WP_121331722.1 OXA-10 family class D beta-lactamase OXA-932 blaOXA-935 NG_070900.1 WP_141989064.1 OXA-10 family class D beta-lactamase OXA-935 plus VIRULENCE VIRULENCE cnf3 AM263062.1 CAK19001.1 cytotoxic necrotizing factor CNF3 cnf2 AGIA01000141.1 EID64799.1 cytotoxic necrotizing factor CNF2 Added point mutations core AMR POINT 23S_A2114G MACROLIDE Streptococcus_pneumoniae 23S_A2115G MACROLIDE Streptococcus_pneumoniae 23S_A2118G MACROLIDE/STREPTOGRAMIN Streptococcus_pneumoniae 23S_C2630A MACROLIDE Streptococcus_pneumoniae 23S_C2630G MACROLIDE Streptococcus_pneumoniae adeR_A91V EFFLUX Acinetobacter_baumannii adeR_D20N EFFLUX Acinetobacter_baumannii adeR_E219A EFFLUX Acinetobacter_baumannii adeR_L192R EFFLUX Acinetobacter_baumannii adeR_P116L EFFLUX Acinetobacter_baumannii adeR_P56S EFFLUX Acinetobacter_baumannii adeS_G336S EFFLUX Acinetobacter_baumannii adeS_H189Y EFFLUX Acinetobacter_baumannii adeS_I252S EFFLUX Acinetobacter_baumannii adeS_N125K EFFLUX Acinetobacter_baumannii adeS_Q163STOP EFFLUX Acinetobacter_baumannii adeS_R152K EFFLUX Acinetobacter_baumannii adeS_T153M EFFLUX Acinetobacter_baumannii folP_F25I SULFONAMIDE Streptococcus_pyogenes ftsI_A515V CARBAPENEM Acinetobacter_baumannii gyrA_G79C QUINOLONE Acinetobacter_baumannii gyrA_S81L QUINOLONE Acinetobacter_baumannii parC_D83H QUINOLONE Streptococcus_pneumoniae parC_E88K QUINOLONE Acinetobacter_baumannii parC_S79F QUINOLONE Streptococcus_pneumoniae parC_S79Y QUINOLONE Streptococcus_pneumoniae parC_S84F QUINOLONE Acinetobacter_baumannii parC_S84L QUINOLONE Acinetobacter_baumannii parC_S84W QUINOLONE Acinetobacter_baumannii pbp1a_N609D BETA-LACTAM Streptococcus_pneumoniae pbp1a_S575T BETA-LACTAM Streptococcus_pneumoniae pbp1a_T371S BETA-LACTAM Streptococcus_pneumoniae pbp2b_E476G BETA-LACTAM Streptococcus_pneumoniae pbp2b_T446A BETA-LACTAM Streptococcus_pneumoniae pbp2b_T489A BETA-LACTAM Streptococcus_pneumoniae pbp2x_I371T BETA-LACTAM Streptococcus_pneumoniae pbp2x_L546V BETA-LACTAM Streptococcus_pneumoniae pbp2x_M339T BETA-LACTAM Streptococcus_pneumoniae pbp2x_M400T BETA-LACTAM Streptococcus_pneumoniae pbp2x_N514H BETA-LACTAM Streptococcus_pneumoniae pbp2x_N605T BETA-LACTAM Streptococcus_pneumoniae pbp2x_P601L BETA-LACTAM Streptococcus_pyogenes pbp2x_Q557E BETA-LACTAM Streptococcus_agalactiae Moved proteins (sequence didn't change but have been moved from core to plus) Removed core AMR AMR blaEC NG_047494.1 WP_001336292.1 BlaEC family class C beta-lactamase blaEC NG_047496.1 WP_001460207.1 BlaEC family class C beta-lactamase blaEC NG_047495.1 WP_063842627.1 BlaEC family class C beta-lactamase Replaced with plus AMR AMR blaEC U00096.3 AAC77110.1 BlaEC family class C beta-lactamase blaEC AF124202.1 AAD28042.1 BlaEC family class C beta-lactamase blaEC EF507685.1 ABS58643.1 BlaEC family class C beta-lactamase Removed proteins plus AMR AMR cprR AE004091.2 AAG06465.1 cationic peptide response regulator transcription factor CprR cprS AE004091.2 AAG06466.1 cationic peptide sensor histidine kinase CprS txr AF353562.1 AAK37618.1 putative sigma-54-dependent transcription factor Txr arnT FO834906.1 CDO12042.1 lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase Changed reference gene catalog records lmrS AAW38464.1 class: EFFLUX -> MACROLIDE/PHENICOL subclass: EFFLUX -> ERYTHROMYCIN/CHLORAMPHENICOL abaF ABO11759.2 class: LINCOSAMIDE -> FOSFOMYCIN subclass: LINCOSAMIDE -> FOSFOMYCIN crcB CCN31428.1 class: -> FLUORIDE subclass: -> FLUORIDE subtype: AMR -> BIOCIDE type: AMR -> STRESS blaOXA-427 WP_096807440.1 subclass: BETA-LACTAM -> CARBAPENEM Added families blaAAK NF038195.1 AAK family class A beta-lactamase cml - Cml family chloramphenicol efflux MFS transporter cnf2 - cytotoxic necrotizing factor CNF2 cnf3 - cytotoxic necrotizing factor CNF3 estX - alpha/beta fold putative hydrolase EstX gar - gentamicin resistance ATP-binding protein Gar gar_fam - garosamine-type aminoglycoside resistance ATP-binding protein grdA - gentamicin resistance ATP-binding protein GrdA lnu(E) NF000478.2 lincosamide nucleotidyltransferase Lnu(E) tet(43) NF012180.1 tetracycline efflux MFS transporter Tet(43) Removed families arnT - lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase cprR - cationic peptide response regulator transcription factor CprR cprS - cationic peptide sensor histidine kinase CprS txr - putative sigma-54-dependent transcription factor Txr Family changes cml CmlA/FloR family chloramphenicol efflux MFS transporter gene_symbol: bcr/cflA -> cml cnf CNF1 family cytotoxic necrotizing factor hmm_id: NF033651.1 -> - espJ EspJ family T3SS effector ADP-ribosyltransferase hmm_id: NF033643.1 -> - ---------------------------------------------------------------------- Changes included in 2020-09-30.1 ---------------------------------------------------------------------- NOTE: This is a data fix release. This data release contains no new genes and will not affect which genes are detected by AMRFinderPlus. We are making this release because a few incomplete NG_ accessions made it through our QC process and were included in the Reference Gene Catalog for the previous 2020-09-22.2 release. These have no effect on AMRFinderPlus results. No new genes have been added, but we took this opportunity to clean up the database by removing a few families and HMMs that are not in the Reference Gene Catalog nor used by AMRFinderPlus for element identification, but were used internally for organization and QC purposes. Summary: Total proteins: 6503 Core proteins: 5625 Plus proteins: 878 AMR proteins: 5662 STRESS proteins: 210 VIRULENCE proteins: 631 Point mutations: 682 Point mutation references: 91 Point mutation organism groups: Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus HMMs: 627 Updates since release 2020-09-22.2: Reference Gene Catalog entries changed: 12 Families removed: 2 Families changed: 1 Changed reference gene catalog records blaLRA1 WP_063842263.1 refseq_nucleotide_accession: NG_047484. -> NG_047484.1 blaLRA5 WP_063842268.1 refseq_nucleotide_accession: NG_047485. -> NG_047485.1 blaLRA2 WP_063842701.1 refseq_nucleotide_accession: NG_047519. -> NG_047519.1 blaLRA3 WP_063842702.1 refseq_nucleotide_accession: NG_047520. -> NG_047520.1 blaLRA8 WP_063842703.1 refseq_nucleotide_accession: NG_047521. -> NG_047521.1 blaLRA9 WP_063842704.1 refseq_nucleotide_accession: NG_047522. -> NG_047522.1 blaLRA12 WP_063842707.1 refseq_nucleotide_accession: NG_047523. -> NG_047523.1 blaLRA17 WP_063842712.1 refseq_nucleotide_accession: NG_047524. -> NG_047524.1 blaLRA19 WP_063842717.1 refseq_nucleotide_accession: NG_047525. -> NG_047525.1 blaLRA18 WP_099982801.1 refseq_nucleotide_accession: NG_055765. -> NG_055765.1 blaLRA7 WP_099982802.1 refseq_nucleotide_accession: NG_055766. -> NG_055766.1 blaLRA10 WP_099982803.1 refseq_nucleotide_accession: NG_055767. -> NG_055767.1 Removed families lnu(E) NF000478.2 lincosamide nucleotidyltransferase Lnu(E) tet(43) NF012180.1 tetracycline efflux MFS transporter Tet(43) Family changes qnr Qnr family pentapeptide repeat protein hmm_id: NF033086.2 -> - ---------------------------------------------------------------------- Changes included in 2020-09-22.2 ---------------------------------------------------------------------- Highlights: - Addition of reference publications for beta-lactamases - New families for improved and finer grain organization/naming of van genes - Improved names for blaLRA families - mcr-9 reclassified from "core" to "plus" on the basis of Tyson et al. 2020 (pmid: 32513803) which showed no effect on colistin phenotype in many E. coli and Salmonella strains - Improved class/subclass for AAC(3)-IVa & AAC(3)-IVb - vanX-E and vanH-E renamed to vanX-F and vanH-F - Several new gene families Summary: Total proteins: 6503 Core proteins: 5625 Plus proteins: 878 AMR proteins: 5662 STRESS proteins: 210 VIRULENCE proteins: 631 Point mutations: 682 Point mutation references: 91 Point mutation organism groups: Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus HMMs: 630 Updates since release 2020-07-16.2: Proteins added: 75 Core proteins added: 65 Plus proteins added: 10 AMR proteins added: 74 VIRULENCE proteins added: 1 Alleles added: 59 Protiens removed: 0 Reference Gene Catalog entries changed: 604 Families added: 22 Families removed: 0 Families changed: 58 Added proteins core AMR AMR vanS-Sc NG_070727.1 WP_003975349.1 VanSc-type vancomycin resistance histidine kinase VanS vanR-Sc NG_070726.1 WP_011029105.1 VanSc-type vancomycin resistance response regulator transcription factor VanR mef(D) NG_070723.1 WP_099483400.1 macrolide efflux MFS transporter Mef(D) dfrA37 NG_070720.1 WP_132586462.1 trimethoprim-resistant dihydrofolate reductase DfrA37 msrH NG_070725.1 WP_138070341.1 ABC-F type ribosomal protection protein Msr(H) dfrA39 NG_070722.1 WP_149100971.1 trimethoprim-resistant dihydrofolate reductase DfrA39 ant(3'')-Ib NG_070719.1 WP_149316740.1 aminoglycoside nucleotidyltransferase ANT(3'')-Ib aac(3)-IVb NG_070718.1 WP_149317372.1 aminoglycoside N-acetyltransferase AAC(3)-IVb msrF NG_070724.1 WP_164941513.1 ABC-F type ribosomal protection protein Msr(F) dfrA38 NG_070721.1 WP_188331861.1 trimethoprim-resistant dihydrofolate reductase DfrA38 blaACC-8 NG_070728.1 WP_188331862.1 cephalosporin-hydrolyzing class C beta-lactamase ACC-8 blaADC-236 NG_070226.1 WP_176673601.1 class C beta-lactamase ADC-236 blaCARB-53 NG_070729.1 WP_188331863.1 PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-53 blaCTX-M-237 NG_070730.1 WP_188331864.1 class A extended-spectrum beta-lactamase CTX-M-237 blaCTX-M-238 NG_070731.1 WP_188331865.1 class A extended-spectrum beta-lactamase CTX-M-238 blaCTX-M-239 NG_070732.1 WP_188331866.1 class A extended-spectrum beta-lactamase CTX-M-239 blaCTX-M-240 NG_070733.1 WP_182496339.1 class A extended-spectrum beta-lactamase CTX-M-240 blaCTX-M-241 NG_070734.1 WP_188331867.1 class A extended-spectrum beta-lactamase CTX-M-241 blaGES-44 NG_070735.1 WP_188331868.1 class A beta-lactamase GES-44 blaGES-45 NG_070736.1 WP_188331869.1 class A beta-lactamase GES-45 blaIMP-88 NG_070737.1 WP_188331870.1 subclass B1 metallo-beta-lactamase IMP-88 blaIMP-89 NG_070738.1 WP_181727105.1 subclass B1 metallo-beta-lactamase IMP-89 blaKPC-66 NG_070739.1 WP_188331871.1 inhibitor-resistant class A extended-spectrum beta-lactamase KPC-66 blaKPC-72 NG_070740.1 WP_188331872.1 inhibitor-resistant class A extended-spectrum beta-lactamase KPC-72 blaKPC-73 NG_070741.1 WP_188331873.1 inhibitor-resistant class A extended-spectrum beta-lactamase KPC-73 blaKPC-74 NG_070742.1 WP_188331874.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-74 blaKPC-75 NG_070743.1 WP_188331875.1 carbapenem-hydrolyzing class A beta-lactamase KPC-75 blaLMB-1 NG_070744.1 WP_108361548.1 subclass B3 metallo-beta-lactamase LMB-1 blaOXA-900 NG_070745.1 WP_178317675.1 class D beta-lactamase OXA-900 blaOXA-919 NG_070746.1 WP_007879679.1 class D beta-lactamase OXA-919 blaOXA-922 NG_070747.1 WP_188331876.1 OXA-48 family class D beta-lactamase OXA-922 blaOXA-926 NG_070748.1 WP_114268491.1 class D beta-lactamase OXA-926 blaOXA-928 NG_070749.1 WP_188331877.1 OXA-10 family class D beta-lactamase OXA-928 blaOXA-929 NG_070750.1 WP_188331878.1 OXA-48 family class D beta-lactamase OXA-929 blaPDC-453 NG_070227.1 WP_179945705.1 class C beta-lactamase PDC-453 blaPDC-454 NG_070228.1 WP_141563014.1 class C beta-lactamase PDC-454 blaPDC-455 NG_070229.1 WP_058135553.1 class C beta-lactamase PDC-455 blaPDC-456 NG_070751.1 WP_188331879.1 class C beta-lactamase PDC-456 blaPDC-457 NG_070752.1 WP_094954583.1 class C beta-lactamase PDC-457 blaROB-10 NG_070753.1 WP_116743769.1 class A beta-lactamase ROB-10 blaSRT-3 NG_070754.1 WP_033642964.1 class C beta-lactamase SRT-3 blaVEB-27 NG_070755.1 WP_188331880.1 inhibitor-resistant class A extended-spectrum beta-lactamase VEB-27 blaVIM-72 NG_070756.1 WP_188331881.1 subclass B1 metallo-beta-lactamase VIM-72 blaVIM-73 NG_070757.1 WP_188331882.1 subclass B1 metallo-beta-lactamase VIM-73 blaVMB-1 NG_070758.1 WP_172692932.1 subclass B1 metallo-beta-lactamase VMB-1 blaYEM-1 NG_070759.1 WP_004874166.1 subclass B2 metallo-beta-lactamase YEM-1 fosL1 NG_070760.1 WP_161667239.1 fosfomycin resistance glutathione transferase FosL1 fosL2 NG_070761.1 WP_188331883.1 fosfomycin resistance glutathione transferase FosL2 mcr-1.28 NG_070762.1 WP_181464119.1 phosphoethanolamine--lipid A transferase MCR-1.28 mcr-1.29 NG_070763.1 WP_188331884.1 phosphoethanolamine--lipid A transferase MCR-1.29 mcr-1.30 NG_070764.1 WP_188331885.1 phosphoethanolamine--lipid A transferase MCR-1.30 mcr-2.4 NG_070765.1 WP_188331886.1 phosphoethanolamine--lipid A transferase MCR-2.4 mcr-2.5 NG_070766.1 WP_188331887.1 phosphoethanolamine--lipid A transferase MCR-2.5 mcr-2.6 NG_070767.1 WP_188331888.1 phosphoethanolamine--lipid A transferase MCR-2.6 mcr-2.7 NG_070768.1 WP_188331889.1 phosphoethanolamine--lipid A transferase MCR-2.7 mcr-3.31 NG_070769.1 WP_188331890.1 phosphoethanolamine--lipid A transferase MCR-3.31 mcr-3.32 NG_070770.1 WP_188331891.1 phosphoethanolamine--lipid A transferase MCR-3.32 mcr-3.33 NG_070771.1 WP_188331892.1 phosphoethanolamine--lipid A transferase MCR-3.33 mcr-3.34 NG_070772.1 WP_188331893.1 phosphoethanolamine--lipid A transferase MCR-3.34 mcr-3.35 NG_070773.1 WP_188331894.1 phosphoethanolamine--lipid A transferase MCR-3.35 mcr-3.36 NG_070774.1 WP_188331895.1 phosphoethanolamine--lipid A transferase MCR-3.36 mcr-3.37 NG_070775.1 WP_188331896.1 phosphoethanolamine--lipid A transferase MCR-3.37 mcr-3.38 NG_070776.1 WP_039039919.1 phosphoethanolamine--lipid A transferase MCR-3.38 mcr-3.39 NG_070777.1 WP_114500971.1 phosphoethanolamine--lipid A transferase MCR-3.39 mcr-3.40 NG_070778.1 WP_188331897.1 phosphoethanolamine--lipid A transferase MCR-3.40 qnrA11 NG_070779.1 WP_188331898.1 quinolone resistance pentapeptide repeat protein QnrA11 qnrA12 NG_070780.1 WP_188331899.1 quinolone resistance pentapeptide repeat protein QnrA12 plus AMR AMR cprR AE004091.2 AAG06465.1 cationic peptide response regulator transcription factor CprR cprS AE004091.2 AAG06466.1 cationic peptide sensor histidine kinase CprS txr AF353562.1 AAK37618.1 putative sigma-54-dependent transcription factor Txr ranA CP002562.1 ADZ12699.1 multidrug efflux ABC transporter ATP-binding subunit RanA ranB CP002562.1 ADZ12700.1 multidrug efflux ABC transporter permease subunit RanB crcB HF536482.1 CCN31428.1 fluoride efflux transporter CrcB arnT FO834906.1 CDO12042.1 lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase mcr-9.1 MK070339.1 AYW01299.1 phosphoethanolamine--lipid A transferase MCR-9.1 mcr-9.3 MT505326.1 QKF95689.1 phosphoethanolamine--lipid A transferase MCR-9.3 plus VIRULENCE VIRULENCE sinH AE006468.2 AAL21411.1 intimin-like inverse autotransporter SinH Removed proteins core AMR AMR mcr-9.1 NG_064792.1 WP_001572373.1 phosphoethanolamine--lipid A transferase MCR-9.1 mcr-9.3 NG_070224.1 WP_179284395.1 phosphoethanolamine--lipid A transferase MCR-9.3 Changed reference gene catalog records abaF ABO11759.2 class: -> LINCOSAMIDE subclass: -> LINCOSAMIDE lmrC ABX00624.1 class: -> FOSFOMYCIN subclass: -> FOSFOMYCIN aac(3)-IVa WP_001199192.1 pubmed_reference: -> 15231771 subclass: GENTAMICIN -> APRAMYCIN/GENTAMICIN/TOBRAMYCIN vanR-A WP_001280781.1 gene_family: vanR -> vanR-A vanS-A WP_002305818.1 gene_family: vanS -> vanS-A vanR-B WP_002317273.1 gene_family: vanR -> vanR-B vanW-B WP_002368694.1 gene_family: vanW -> vanW-B vanS-B WP_002368696.1 gene_family: vanS -> vanS-B vanR-B WP_002368697.1 gene_family: vanR -> vanR-B vanS-B WP_002382867.1 gene_family: vanS -> vanS-B vanR-C WP_003126775.1 gene_family: vanR -> vanR-C vanT-C WP_003126777.1 gene_family: vanT -> vanT-C vanR-Cd WP_003436401.1 gene_family: vanR -> vanR-Cd product_name: VanG-Cd-type vancomycin resistance DNA-binding response regulator VanS -> VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR vanR-C WP_005228837.1 gene_family: vanR -> vanR-C vanW-I WP_005813024.1 gene_family: vanWI -> vanW-I product_name: glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-I vanR-F WP_006285581.1 gene_family: vanR -> vanR-F vanS-F WP_006285582.1 gene_family: vanS -> vanS-F vanH-F WP_006285586.1 gene_family: vanH-E -> vanH-F product_name: D-lactate dehydrogenase VanH-E -> D-lactate dehydrogenase VanH-F vanX-F WP_006285588.1 gene_family: vanX-E -> vanX-F product_name: D-Ala-D-Ala dipeptidase VanX-E -> D-Ala-D-Ala dipeptidase VanX-F vanW-B WP_010815683.1 gene_family: vanW -> vanW-B vanR-I WP_011461303.1 gene_family: vanR -> vanR-I vanK-I WP_011461306.1 gene_family: vanKI -> vanK-I vanS-Cd WP_011861275.1 gene_family: vanS -> vanS-Cd vanS-B WP_012579101.1 gene_family: vanS -> vanS-B vanX-I WP_015943580.1 gene_family: vanXI -> vanX-I vanR-D WP_016295750.1 gene_family: vanR -> vanR-D vanT-G WP_021418922.1 gene_family: vanT -> vanT-G vanS-G WP_021418927.1 gene_family: vanS -> vanS-G vanR-G WP_021418928.1 gene_family: vanR -> vanR-G vanU-G WP_021418929.1 gene_family: vanU -> vanU-G product_name: glycopeptide resistance transcriptional regulator VanU -> glycopeptide resistance transcriptional regulator VanU-G vanW-G WP_021419095.1 gene_family: vanW -> vanW-G vanS-D WP_023042297.1 gene_family: vanS -> vanS-D vanR-D WP_023042613.1 gene_family: vanR -> vanR-D vanR-D WP_023043165.1 gene_family: vanR -> vanR-D vanS-D WP_028530133.1 gene_family: vanS -> vanS-D vanR-B WP_032489743.1 gene_family: vanR -> vanR-B vanW-B WP_032489744.1 gene_family: vanW -> vanW-B vanS-C WP_034869172.1 gene_family: vanS -> vanS-C vanR-C WP_034872470.1 gene_family: vanR -> vanR-C erm(30) WP_055641627.1 subclass: ERYTHROMYCIN -> MACROLIDE blaLRA1 WP_063842263.1 gene_family: bla -> blaLRA1 product_name: class A beta-lactamase LRA-1 -> LRA1 family class A beta-lactamase refseq_nucleotide_accession: NG_047484.1 -> NG_047484. blaLRA5 WP_063842268.1 gene_family: bla -> blaLRA5 product_name: class A beta-lactamase LRA-5 -> LRA5 family class A beta-lactamase refseq_nucleotide_accession: NG_047485.1 -> NG_047485. blaLRA2 WP_063842701.1 gene_family: blaLRA -> blaLRA2 product_name: subclass B3 metallo-beta-lactamase LRA-2 -> LRA2 family subclass B3 metallo-beta-lactamase refseq_nucleotide_accession: NG_047519.1 -> NG_047519. blaLRA3 WP_063842702.1 gene_family: blaLRA -> blaLRA3 product_name: subclass B3 metallo-beta-lactamase LRA-3 -> LRA3 family subclass B3 metallo-beta-lactamase refseq_nucleotide_accession: NG_047520.1 -> NG_047520. blaLRA8 WP_063842703.1 gene_family: blaLRA -> blaLRA8 product_name: subclass B3 metallo-beta-lactamase LRA-8 -> LRA8 family subclass B3 metallo-beta-lactamase refseq_nucleotide_accession: NG_047521.1 -> NG_047521. blaLRA9 WP_063842704.1 gene_family: blaLRA -> blaLRA9 product_name: subclass B3 metallo-beta-lactamase LRA-9 -> LRA9 family subclass B3 metallo-beta-lactamase refseq_nucleotide_accession: NG_047522.1 -> NG_047522. blaLRA12 WP_063842707.1 gene_family: blaLRA -> blaLRA12 product_name: subclass B3 metallo-beta-lactamase LRA-12 -> LRA12 family subclass B3 metallo-beta-lactamase refseq_nucleotide_accession: NG_047523.1 -> NG_047523. blaLRA17 WP_063842712.1 gene_family: blaLRA -> blaLRA17 product_name: subclass B3 metallo-beta-lactamase LRA-17 -> LRA17 family subclass B3 metallo-beta-lactamase refseq_nucleotide_accession: NG_047524.1 -> NG_047524. blaLRA19 WP_063842717.1 gene_family: blaLRA -> blaLRA19 product_name: subclass B3 metallo-beta-lactamase LRA-19 -> LRA19 family subclass B3 metallo-beta-lactamase refseq_nucleotide_accession: NG_047525.1 -> NG_047525. erm(31) WP_063844492.1 subclass: ERYTHROMYCIN -> MACROLIDE vanR-D WP_063856715.1 gene_family: vanR -> vanR-D vanR-A WP_063856716.1 gene_family: vanR -> vanR-A vanR-E WP_063856718.1 gene_family: vanR -> vanR-E vanR-B WP_063856719.1 gene_family: vanR -> vanR-B vanR-A WP_063856720.1 gene_family: vanR -> vanR-A vanR-A WP_063856721.1 gene_family: vanR -> vanR-A vanR-D WP_063856722.1 gene_family: vanR -> vanR-D vanR-B WP_063856723.1 gene_family: vanR -> vanR-B vanR-L WP_063856724.1 gene_family: vanR -> vanR-L vanR-C WP_063856725.1 gene_family: vanR -> vanR-C vanR-M WP_063856726.1 gene_family: vanR -> vanR-M vanR-D WP_063856727.1 gene_family: vanR -> vanR-D vanR-N WP_063856728.1 gene_family: vanR -> vanR-N vanR-O WP_063856729.1 gene_family: vanR -> vanR-O vanS-D WP_063856730.1 gene_family: vanS -> vanS-D vanS-A WP_063856731.1 gene_family: vanS -> vanS-A vanS-G WP_063856732.1 gene_family: vanS -> vanS-G vanS-C WP_063856733.1 gene_family: vanS -> vanS-C vanS-E WP_063856734.1 gene_family: vanS -> vanS-E vanS-D WP_063856738.1 gene_family: vanS -> vanS-D vanS-B WP_063856739.1 gene_family: vanS -> vanS-B vanS-Pt2 WP_063856740.1 gene_family: vanS -> vanS-Pt2 vanS-Pt WP_063856741.1 gene_family: vanS -> vanS-Pt vanS-Pt WP_063856742.1 gene_family: vanS -> vanS-Pt vanS-C WP_063856743.1 gene_family: vanS -> vanS-C vanS-D WP_063856744.1 gene_family: vanS -> vanS-D vanS-L WP_063856745.1 gene_family: vanS -> vanS-L vanS-M WP_063856748.1 gene_family: vanS -> vanS-M vanS-N WP_063856749.1 gene_family: vanS -> vanS-N vanS-B WP_063856751.1 gene_family: vanS -> vanS-B vanT-G WP_063856752.1 gene_family: vanT -> vanT-G vanT-E WP_063856753.1 gene_family: vanT -> vanT-E vanT-C WP_063856754.1 gene_family: vanT -> vanT-C vanT-C WP_063856755.1 gene_family: vanT -> vanT-C vanT-C WP_063856756.1 gene_family: vanT -> vanT-C vanT-N WP_063856757.1 gene_family: vanT -> vanT-N vanW-G WP_063856762.1 gene_family: vanW -> vanW-G vanW-B WP_063856763.1 gene_family: vanW -> vanW-B vanW-Pt WP_063856764.1 gene_family: vanW -> vanW-Pt product_name: glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-Pt vanW-B WP_063856765.1 gene_family: vanW -> vanW-B vanW-B WP_063856766.1 gene_family: vanW -> vanW-B vanS-O WP_070064533.1 gene_family: vanS -> vanS-O vanT-Cd WP_071593222.1 gene_family: vanT -> vanT-Cd blaLRA18 WP_099982801.1 product_name: LRA-18 family class C beta-lactamase -> LRA18 family class C beta-lactamase refseq_nucleotide_accession: NG_055765.1 -> NG_055765. blaLRA7 WP_099982802.1 gene_family: blaLRA -> blaLRA7 product_name: subclass B3 metallo-beta-lactamase LRA-7 -> LRA7 family subclass B3 metallo-beta-lactamase refseq_nucleotide_accession: NG_055766.1 -> NG_055766. blaLRA10 WP_099982803.1 product_name: LRA-10 family class C beta-lactamase -> LRA10 family class C beta-lactamase refseq_nucleotide_accession: NG_055767.1 -> NG_055767. blaACC-1 WP_032491956.1 pubmed_reference: -> 10428914 blaACC-2 WP_063857702.1 pubmed_reference: -> 10817695 blaACC-4 WP_063857708.1 pubmed_reference: -> 17664321 blaACC-5 WP_063857715.1 pubmed_reference: -> 24267783 blaACT-1 WP_063857727.1 pubmed_reference: -> 9055993 blaACT-10 WP_063857730.1 pubmed_reference: -> 25312010 blaACT-12 WP_025206265.1 pubmed_reference: -> 25501887 blaACT-14 WP_063138000.1 pubmed_reference: -> 25501887 blaACT-15 WP_023295792.1 pubmed_reference: -> 25501887 blaACT-16 WP_023315250.1 pubmed_reference: -> 24336426 blaACT-17 WP_017694683.1 pubmed_reference: -> 25501887 blaACT-18 WP_063857768.1 pubmed_reference: -> 25501887 blaACT-19 WP_047354536.1 pubmed_reference: -> 25501887 blaACT-22 WP_063857771.1 pubmed_reference: -> 25501887 blaACT-23 WP_045620946.1 pubmed_reference: -> 24629772 blaACT-3 WP_063857773.1 pubmed_reference: -> 18789849 blaACT-9 WP_013981172.1 pubmed_reference: -> 21690276 blaBEL-1 WP_063857830.1 pubmed_reference: -> 16127048 blaBEL-2 WP_063857831.1 pubmed_reference: -> 19884378 blaBEL-3 WP_063857832.1 pubmed_reference: -> 19933793 blaCARB-1 WP_063857835.1 pubmed_reference: -> 377324, 11959558 blaCARB-10 WP_063857836.1 pubmed_reference: -> 19380596 blaCARB-14 WP_063857843.1 pubmed_reference: -> 22633451 blaCARB-17 WP_023624728.1 pubmed_reference: -> 25801555 blaCARB-2 WP_001931474.1 pubmed_reference: -> 377324, 410783, 1804019 blaCARB-4 WP_032489168.1 pubmed_reference: -> 3087285, 9687391 blaCARB-5 WP_063859341.1 pubmed_reference: -> 2786828, 10722515 blaCARB-6 WP_063859348.1 pubmed_reference: -> 9925522 blaCARB-7 WP_029628776.1 pubmed_reference: -> 12069969 blaCARB-8 WP_063859363.1 pubmed_reference: -> 12709319 blaCARB-9 WP_002022164.1 pubmed_reference: -> 15388476 blaCFE-1 WP_032490699.1 pubmed_reference: -> 15047515 blaCMY-1 WP_032488864.1 pubmed_reference: -> 8843306 blaCMY-10 WP_032492452.1 pubmed_reference: -> 12969288 blaCMY-107 WP_032494240.1 pubmed_reference: -> 26438499 blaCMY-108 WP_063859673.1 pubmed_reference: -> 24500191 blaCMY-11 WP_032492458.1 pubmed_reference: -> 11815567 blaCMY-110 WP_063859688.1 pubmed_reference: -> 24709044 blaCMY-12 WP_063859743.1 pubmed_reference: -> 12407124 blaCMY-13 WP_020996270.1 pubmed_reference: -> 15273143 blaCMY-14 WP_063859816.1 pubmed_reference: -> 15504832 blaCMY-15 WP_063859817.1 pubmed_reference: -> 15504832 blaCMY-16 WP_014386387.1 pubmed_reference: -> 16436718 blaCMY-18 WP_063859824.1 pubmed_reference: -> 16584308 blaCMY-19 WP_063859826.1 pubmed_reference: -> 16436707 blaCMY-2 WP_000976514.1 pubmed_reference: -> 8787910 blaCMY-20 WP_063859827.1 pubmed_reference: -> 18207348 blaCMY-21 WP_063859828.1 pubmed_reference: -> 16716570 blaCMY-23 WP_000976515.1 pubmed_reference: -> 17110393 blaCMY-24 WP_032491928.1 pubmed_reference: -> 17587551 blaCMY-25 WP_003830525.1 pubmed_reference: -> 19523051 blaCMY-26 WP_063859830.1 pubmed_reference: -> 17720829 blaCMY-27 WP_063859831.1 pubmed_reference: -> 19523051 blaCMY-29 WP_063859833.1 pubmed_reference: -> 19414570 blaCMY-30 WP_000976513.1 pubmed_reference: -> 19414570 blaCMY-31 WP_012262157.1 pubmed_reference: -> 18065410 blaCMY-36 WP_012262164.1 pubmed_reference: -> 19104021 blaCMY-37 WP_063859838.1 pubmed_reference: -> 18619820 blaCMY-38 WP_063553425.1 pubmed_reference: -> 18458126 blaCMY-4 WP_015056382.1 pubmed_reference: -> 9868767 blaCMY-40 WP_063859840.1 pubmed_reference: -> 19523051 blaCMY-41 WP_048241752.1 pubmed_reference: -> 19343954 blaCMY-42 WP_039023136.1 pubmed_reference: -> 21388298 blaCMY-45 WP_063859843.1 pubmed_reference: -> 21402851 blaCMY-5 WP_015059331.1 pubmed_reference: -> 10348751 blaCMY-54 WP_063859848.1 pubmed_reference: -> 22956023 blaCMY-55 WP_063859849.1 pubmed_reference: -> 22956023 blaCMY-56 WP_063859850.1 pubmed_reference: -> 22956023 blaCMY-57 WP_063859851.1 pubmed_reference: -> 22956023 blaCMY-65 WP_008321445.1 pubmed_reference: -> 25501887 blaCMY-66 WP_063859858.1 pubmed_reference: -> 25501887 blaCMY-67 WP_063859859.1 pubmed_reference: -> 25501887 blaCMY-68 WP_063859860.1 pubmed_reference: -> 25501887 blaCMY-7 WP_032490765.1 pubmed_reference: -> 12039894 blaCMY-70 WP_046275846.1 pubmed_reference: -> 25501887 blaCMY-71 WP_063859862.1 pubmed_reference: -> 25501887 blaCMY-74 WP_063859864.1 pubmed_reference: -> 25501887 blaCMY-8 WP_012477380.1 pubmed_reference: -> 10817689 blaCMY-83 WP_063859873.1 pubmed_reference: -> 25501887 blaCMY-9 WP_032490177.1 pubmed_reference: -> 12121914 blaCMY-93 WP_063859914.1 pubmed_reference: -> 25501887 blaCMY-99 WP_063859919.1 pubmed_reference: -> 24165184 blaCTX-M-1 WP_013188473.1 pubmed_reference: -> 8834913 blaCTX-M-10 WP_032491157.1 pubmed_reference: -> 11158766 blaCTX-M-100 WP_032494234.1 pubmed_reference: -> 23050014 blaCTX-M-116 WP_032495225.1 pubmed_reference: -> 23318795 blaCTX-M-117 WP_032495259.1 pubmed_reference: -> 23127481 blaCTX-M-12 WP_032491777.1 pubmed_reference: -> 11408239 blaCTX-M-123 WP_031942271.1 pubmed_reference: -> 23752509 blaCTX-M-124 WP_063859945.1 pubmed_reference: -> 22330908 blaCTX-M-13 WP_032489927.1 pubmed_reference: -> 11850241 blaCTX-M-131 WP_063859950.1 pubmed_reference: -> 25583719 blaCTX-M-132 WP_063859951.1 pubmed_reference: -> 26169409 blaCTX-M-137 WP_063859954.1 pubmed_reference: -> 24777903 blaCTX-M-14 WP_001617865.1 pubmed_reference: -> 11850241 blaCTX-M-15 WP_000239590.1 pubmed_reference: -> 11470367 blaCTX-M-16 WP_063859967.1 pubmed_reference: -> 11451684 blaCTX-M-17 WP_011117618.1 pubmed_reference: -> 11959547 blaCTX-M-19 WP_063860037.1 pubmed_reference: -> 11709308 blaCTX-M-2 WP_025368620.1 pubmed_reference: -> 8834913 blaCTX-M-20 WP_063860038.1 pubmed_reference: -> 12007800 blaCTX-M-21 WP_063860039.1 pubmed_reference: -> 12007800 blaCTX-M-22 WP_032491377.1 pubmed_reference: -> 16533535 blaCTX-M-23 WP_063860040.1 pubmed_reference: -> 15201232 blaCTX-M-24 WP_012579082.1 pubmed_reference: -> 16291869 blaCTX-M-25 WP_022542384.1 pubmed_reference: -> 15561863 blaCTX-M-26 WP_063860041.1 pubmed_reference: -> 12493817 blaCTX-M-27 WP_032277257.1 pubmed_reference: -> 12775683 blaCTX-M-28 WP_063860042.1 pubmed_reference: -> 15941775 blaCTX-M-29 WP_063860043.1 pubmed_reference: -> 16533535 blaCTX-M-3 WP_011091028.1 pubmed_reference: -> 9559791 blaCTX-M-30 WP_032490752.1 pubmed_reference: -> 15504875 blaCTX-M-31 WP_063860044.1 pubmed_reference: -> 12936986 blaCTX-M-32 WP_000239591.1 pubmed_reference: -> 15155242 blaCTX-M-33 WP_032490682.1 pubmed_reference: -> 17234386 blaCTX-M-34 WP_063860045.1 pubmed_reference: -> 16244084 blaCTX-M-37 WP_063860048.1 pubmed_reference: -> 16949257 blaCTX-M-39 WP_044702041.1 pubmed_reference: -> 16251320 blaCTX-M-4 WP_032489025.1 pubmed_reference: -> 9593162 blaCTX-M-40 WP_063860050.1 pubmed_reference: -> 16697557 blaCTX-M-41 WP_063860051.1 pubmed_reference: -> 18487232 blaCTX-M-42 WP_063860052.1 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blaTEM-47 WP_063864914.1 pubmed_reference: -> 9517925 blaTEM-48 WP_063864915.1 pubmed_reference: -> 9517925 blaTEM-49 WP_063864916.1 pubmed_reference: -> 9517925 blaTEM-5 WP_109963600.1 pubmed_reference: -> 2550326 blaTEM-52 WP_015058977.1 pubmed_reference: -> 9449269 blaTEM-53 WP_063864923.1 pubmed_reference: -> 9925535 blaTEM-54 WP_063864930.1 pubmed_reference: -> 9925535 blaTEM-57 WP_032492330.1 pubmed_reference: -> 10543745 blaTEM-6 WP_063864949.1 pubmed_reference: -> 3312022 blaTEM-60 WP_032489150.1 pubmed_reference: -> 9624494 blaTEM-63 WP_055314004.1 pubmed_reference: -> 11120950 blaTEM-67 WP_032490504.1 pubmed_reference: -> 12499163 blaTEM-68 WP_032489741.1 pubmed_reference: -> 10817699 blaTEM-7 WP_109874025.1 pubmed_reference: -> 3055178 blaTEM-71 WP_032490155.1 pubmed_reference: -> 12019125 blaTEM-72 WP_032489614.1 pubmed_reference: -> 10952610 blaTEM-76 WP_063864990.1 pubmed_reference: -> 10991849 blaTEM-77 WP_063864996.1 pubmed_reference: -> 10991849 blaTEM-78 WP_063865003.1 pubmed_reference: -> 10991849 blaTEM-79 WP_063865008.1 pubmed_reference: -> 10991849 blaTEM-8 WP_063865014.1 pubmed_reference: -> 2558614 blaTEM-80 WP_063865024.1 pubmed_reference: -> 11959543 blaTEM-81 WP_063865030.1 pubmed_reference: -> 10991849 blaTEM-82 WP_063865036.1 pubmed_reference: -> 10991849 blaTEM-83 WP_063865043.1 pubmed_reference: -> 10991849 blaTEM-84 WP_063865053.1 pubmed_reference: -> 10991849 blaTEM-85 WP_032490101.1 pubmed_reference: -> 15855509 blaTEM-86 WP_032490102.1 pubmed_reference: -> 15855509 blaTEM-87 WP_032489893.1 pubmed_reference: -> 11850290 blaTEM-88 WP_032489980.1 pubmed_reference: -> 11709362 blaTEM-9 WP_102607453.1 pubmed_reference: -> 3312022 blaTEM-90 WP_032490026.1 pubmed_reference: -> 11557499 blaTEM-91 WP_063865088.1 pubmed_reference: -> 12937007 blaTEM-93 WP_032490317.1 pubmed_reference: -> 15855509 blaTEM-94 WP_032490318.1 pubmed_reference: -> 15855509 blaTEM-95 WP_061659705.1 pubmed_reference: -> 12234838 blaVEB-1 WP_000706731.1 pubmed_reference: -> 10049269 blaVEB-2 WP_063865158.1 pubmed_reference: -> 11807680 blaVEB-24 WP_156404663.1 product_name: class A extended-spectrum beta-lactamase VEB-24 -> inhibitor-resistant class A extended-spectrum beta-lactamase VEB-24 blaVEB-3 WP_020956917.1 pubmed_reference: -> 15695687 blaVEB-4 WP_063865159.1 pubmed_reference: -> 18292096 blaVEB-6 WP_063865161.1 pubmed_reference: -> 18025117 blaVIM-1 WP_013263789.1 pubmed_reference: -> 10390207 blaVIM-11 WP_034080264.1 pubmed_reference: -> 15616342 blaVIM-12 WP_063865167.1 pubmed_reference: -> 16304191 blaVIM-13 WP_063865168.1 pubmed_reference: -> 18644957 blaVIM-14 WP_063865169.1 pubmed_reference: -> 21521413 blaVIM-15 WP_063865170.1 pubmed_reference: -> 18519714 blaVIM-16 WP_063865171.1 pubmed_reference: -> 18519714 blaVIM-17 WP_023442721.1 pubmed_reference: -> 19164147 blaVIM-18 WP_063865172.1 pubmed_reference: -> 19164147 blaVIM-19 WP_032492472.1 pubmed_reference: -> 19917750 blaVIM-2 WP_003108247.1 pubmed_reference: -> 10722487 blaVIM-23 WP_063865174.1 pubmed_reference: -> 20961909 blaVIM-24 WP_063865175.1 pubmed_reference: -> 21282438 blaVIM-26 WP_063865177.1 pubmed_reference: -> 21595797 blaVIM-27 WP_032495187.1 pubmed_reference: -> 21518835 blaVIM-28 WP_063865178.1 pubmed_reference: -> 25241690 blaVIM-3 WP_063865179.1 pubmed_reference: -> 11451678 blaVIM-31 WP_063865181.1 pubmed_reference: -> 22391550 blaVIM-33 WP_063865183.1 pubmed_reference: -> 24185874 blaVIM-34 WP_063865184.1 pubmed_reference: -> 23934739 blaVIM-35 WP_063865185.1 pubmed_reference: -> 25267671 blaVIM-36 WP_063865186.1 pubmed_reference: -> 24603963 blaVIM-37 WP_063865187.1 pubmed_reference: -> 24603963 blaVIM-38 WP_063865188.1 pubmed_reference: -> 24428980 blaVIM-39 WP_063865189.1 pubmed_reference: -> 25759034 blaVIM-4 WP_032492008.1 pubmed_reference: -> 12435718 blaVIM-5 WP_032491390.1 pubmed_reference: -> 15190017 blaVIM-6 WP_063865201.1 pubmed_reference: -> 15155248 blaVIM-7 WP_011997479.1 pubmed_reference: -> 23014719 blaVIM-8 WP_063865202.1 pubmed_reference: -> 15528701 vanS-B-Delta WP_063856737.1 gene_family: vanS -> vanS-B Added families aac(3)-IVb - aminoglycoside N-acetyltransferase AAC(3)-IVb ant(3'')-Ib - aminoglycoside nucleotidyltransferase ANT(3'')-Ib arnT - lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase blaLMB - LMB family subclass B3 metallo-beta-lactamase blaOXA NF038183.1 OXA-919 family class D beta-lactamase blaVMB NF038184.1 VMB family subclass B1 metallo-beta-lactamase blaYEM NF038166.1 YEM family subclass B2 metallo-beta-lactamase cprR - cationic peptide response regulator transcription factor CprR cprS - cationic peptide sensor histidine kinase CprS crcB - fluoride efflux transporter CrcB dfrA37 - trimethoprim-resistant dihydrofolate reductase DfrA37 dfrA38 - trimethoprim-resistant dihydrofolate reductase DfrA38 dfrA39 - trimethoprim-resistant dihydrofolate reductase DfrA39 fos NF033405.1 fosfomycin resistance glutathione transferase FosLL mef(D) - macrolide efflux MFS transporter Mef(D) msrF - ABC-F type ribosomal protection protein Msr(F) msrH - ABC-F type ribosomal protection protein Msr(H) ranA - multidrug efflux ABC transporter ATP-binding subunit RanA ranB - multidrug efflux ABC transporter permease subunit RanB txr - putative sigma-54-dependent transcription factor Txr vanR-Sc - VanSc-type vancomycin resistance response regulator transcription factor VanR vanS-Sc - VanSc-type vancomycin resistance histidine kinase VanS Family changes blaLRA1 LRA1 family class A beta-lactamase gene_symbol: bla -> blaLRA1 family_name: class A beta-lactamase LRA-1 -> LRA1 family class A beta-lactamase blaLRA10 LRA10 family class C beta-lactamase family_name: LRA-10 family class C beta-lactamase -> LRA10 family class C beta-lactamase blaLRA12 LRA12 family subclass B3 metallo-beta-lactamase gene_symbol: blaLRA -> blaLRA12 family_name: subclass B3 metallo-beta-lactamase LRA-12 -> LRA12 family subclass B3 metallo-beta-lactamase blaLRA LRA12 family subclass B3 metallo-beta-lactamase family_name: LRA-12 family subclass B3 metallo-beta-lactamase -> LRA12 family subclass B3 metallo-beta-lactamase blaLRA13 LRA13 family bifunctional class D/class C beta-lactamase gene_symbol: ampC -> blaLRA13 family_name: bifunctional class D/class C beta-lactamase LRA-13 -> LRA13 family bifunctional class D/class C beta-lactamase blaLRA17 LRA17 family subclass B3 metallo-beta-lactamase gene_symbol: blaLRA -> blaLRA17 family_name: subclass B3 metallo-beta-lactamase LRA-17 -> LRA17 family subclass B3 metallo-beta-lactamase blaLRA18 LRA18 family class C beta-lactamase family_name: LRA-18 family class C beta-lactamase -> LRA18 family class C beta-lactamase blaLRA19 LRA19 family subclass B3 metallo-beta-lactamase gene_symbol: blaLRA -> blaLRA19 family_name: subclass B3 metallo-beta-lactamase LRA-19 -> LRA19 family subclass B3 metallo-beta-lactamase blaLRA2 LRA2 family subclass B3 metallo-beta-lactamase gene_symbol: blaLRA -> blaLRA2 family_name: subclass B3 metallo-beta-lactamase LRA-2 -> LRA2 family subclass B3 metallo-beta-lactamase blaLRA LRA2 family subclass B3 metallo-beta-lactamase family_name: LRA-2 family subclass B3 metallo-beta-lactamase -> LRA2 family subclass B3 metallo-beta-lactamase blaLRA3 LRA3 family subclass B3 metallo-beta-lactamase gene_symbol: blaLRA -> blaLRA3 family_name: subclass B3 metallo-beta-lactamase LRA-3 -> LRA3 family subclass B3 metallo-beta-lactamase blaLRA LRA3 family subclass B3 metallo-beta-lactamase family_name: LRA-3 family subclass B3 metallo-beta-lactamase -> LRA3 family subclass B3 metallo-beta-lactamase blaLRA5 LRA5 family class A beta-lactamase gene_symbol: bla -> blaLRA5 family_name: class A beta-lactamase LRA-5 -> LRA5 family class A beta-lactamase blaLRA7 LRA7 family subclass B3 metallo-beta-lactamase gene_symbol: blaLRA -> blaLRA7 family_name: subclass B3 metallo-beta-lactamase LRA-7 -> LRA7 family subclass B3 metallo-beta-lactamase blaLRA8 LRA8 family subclass B3 metallo-beta-lactamase gene_symbol: blaLRA -> blaLRA8 family_name: subclass B3 metallo-beta-lactamase LRA-8 -> LRA8 family subclass B3 metallo-beta-lactamase blaLRA9 LRA9 family subclass B3 metallo-beta-lactamase gene_symbol: blaLRA -> blaLRA9 family_name: subclass B3 metallo-beta-lactamase LRA-9 -> LRA9 family subclass B3 metallo-beta-lactamase fosL fosfomycin resistance glutathione transferase FosL gene_symbol: fos -> fosL hmm_id: NF033405.1 -> - vanK-I peptidoglycan bridge formation peptidyltransferase VanK-I gene_symbol: vanKI -> vanK-I vanR-A VanA-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-A vanR-B VanB-type vancomycin resistance response regulator transcription factor VanR gene_symbol: vanR -> vanR-B vanR-C VanC-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-C vanR-Cd VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-Cd family_name: VanG-Cd-type vancomycin resistance DNA-binding response regulator VanS -> VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR vanR-D VanD-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-D vanR-E VanE-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-E vanR-F VanF-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-F vanR-G VanG-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-G vanR-I VanI-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-I vanR-L VanL-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-L vanR-M VanM-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-M vanR-N VanN-type vancomycin resistance DNA-binding response regulator VanR gene_symbol: vanR -> vanR-N vanR-O VanO-type vancomycin resistance response regulator transcription factor VanR gene_symbol: vanR -> vanR-O vanS-A VanA-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-A vanS-B VanB-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-B vanS-C VanC-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-C vanS-Cd VanG-Cd-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-Cd vanS-D VanD-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-D vanS-E VanE-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-E vanS-F VanF-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-F vanS-G VanG-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-G vanS-L VanL-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-L vanS-M VanM-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-M vanS-N VanN-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-N vanS-O VanO-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-O vanS-Pt VanPt-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-Pt vanS-Pt2 VanPt2-type vancomycin resistance histidine kinase VanS gene_symbol: vanS -> vanS-Pt2 vanT-C membrane-bound serine racemase VanT-C gene_symbol: vanT -> vanT-C vanT-Cd membrane-bound serine racemase VanT-Cd gene_symbol: vanT -> vanT-Cd vanT-E membrane-bound serine racemase VanT-E gene_symbol: vanT -> vanT-E vanT-G membrane-bound serine racemase VanT-G gene_symbol: vanT -> vanT-G vanT-N membrane-bound serine racemase VanT-N gene_symbol: vanT -> vanT-N vanU-G glycopeptide resistance transcriptional regulator VanU-G gene_symbol: vanU -> vanU-G family_name: glycopeptide resistance transcriptional regulator VanU -> glycopeptide resistance transcriptional regulator VanU-G vanW-B glycopeptide resistance accessory protein VanW-B gene_symbol: vanW -> vanW-B vanW-G glycopeptide resistance accessory protein VanW-G gene_symbol: vanW -> vanW-G vanW-I glycopeptide resistance accessory protein VanW-I gene_symbol: vanWI -> vanW-I family_name: glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-I vanW-Pt glycopeptide resistance accessory protein VanW-Pt gene_symbol: vanW -> vanW-Pt family_name: glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-Pt vanX-I D-Ala-D-Ala dipeptidase VanX-I gene_symbol: vanXI -> vanX-I ---------------------------------------------------------------------- Changes included in 2020-07-16.2 ---------------------------------------------------------------------- Highlights: - Users should beware that the literature occasionally provides identical or highly similar gene symbols for unrelated proteins. streptothricin N-acetyltransferases have gene symbols sat2, sat3, etc., while sat as a three-letter gene symbol (changed to match the literature in this release "auto-sat" in previous releases), refers specifically to the serine protease autotransporter toxin Sat. - Added some more specific symbols for already included AME genes - Corrected the class and subclass for smr - 50 new alleles and 1 new AMR gene Summary: Total proteins: 6428 Core proteins: 5560 Plus proteins: 868 AMR proteins: 5588 STRESS proteins: 210 VIRULENCE proteins: 630 Point mutations: 682 Point mutation references: 91 Point mutation organism groups: Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus HMMs: 1574 Updates since release 2020-06-11.1: Proteins added: 52 Core proteins added: 52 Plus proteins added: 0 AMR proteins added: 52 Alleles added: 51 Reference Gene Catalog entries changed: 8 Families added: 4 Families changed: 2 Added proteins core AMR AMR cfr(E) NG_070225.1 WP_105119688.1 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E) blaACT-87 NG_070175.1 WP_121527365.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-87 blaCARB-54 NG_070176.1 WP_179284317.1 RTG family carbenicillin-hydrolyzing class A beta-lactamase CARB-54 blaKPC-58 NG_070177.1 WP_179284320.1 inhibitor-resistant class A beta-lactamase KPC-58 blaKPC-59 NG_070178.1 WP_179284322.1 carbapenem-hydrolyzing class A beta-lactamase KPC-59 blaKPC-60 NG_070179.1 WP_179284324.1 carbapenem-hydrolyzing class A beta-lactamase KPC-60 blaKPC-61 NG_070180.1 WP_179284328.1 carbapenem-hydrolyzing class A beta-lactamase KPC-61 blaOXA-917 NG_070181.1 WP_161507793.1 class D beta-lactamase OXA-917 blaOXA-918 NG_070182.1 WP_179284333.1 OXA-48 family class D beta-lactamase OXA-918 blaOXA-920 NG_070183.1 WP_179284336.1 OXA-48 family class D beta-lactamase OXA-920 blaOXA-921 NG_070184.1 WP_179284339.1 OXA-1 family class D beta-lactamase OXA-921 blaOXA-923 NG_070185.1 WP_179284342.1 OXA-48 family class D beta-lactamase OXA-923 blaOXA-924 NG_070186.1 WP_179284345.1 OXA-48 family class D beta-lactamase OXA-924 blaOXA-925 NG_070187.1 WP_100507493.1 class D beta-lactamase OXA-925 blaPDC-422 NG_070188.1 WP_179284354.1 class C beta-lactamase PDC-422 blaPDC-423 NG_070189.1 WP_134600670.1 class C beta-lactamase PDC-423 blaPDC-424 NG_070190.1 WP_179284357.1 class C beta-lactamase PDC-424 blaPDC-425 NG_070191.1 WP_179284360.1 class C beta-lactamase PDC-425 blaPDC-426 NG_070192.1 WP_179284362.1 class C beta-lactamase PDC-426 blaPDC-427 NG_070193.1 WP_179284365.1 class C beta-lactamase PDC-427 blaPDC-428 NG_070194.1 WP_179284368.1 class C beta-lactamase PDC-428 blaPDC-429 NG_070195.1 WP_179284370.1 class C beta-lactamase PDC-429 blaPDC-430 NG_070196.1 WP_179284371.1 class C beta-lactamase PDC-430 blaPDC-431 NG_070197.1 WP_023118898.1 class C beta-lactamase PDC-431 blaPDC-432 NG_070198.1 WP_179284372.1 class C beta-lactamase PDC-432 blaPDC-433 NG_070199.1 WP_133452685.1 class C beta-lactamase PDC-433 blaPDC-434 NG_070200.1 WP_179284373.1 class C beta-lactamase PDC-434 blaPDC-435 NG_070201.1 WP_179284374.1 class C beta-lactamase PDC-435 blaPDC-436 NG_070202.1 WP_179284375.1 class C beta-lactamase PDC-436 blaPDC-437 NG_070203.1 WP_179284376.1 class C beta-lactamase PDC-437 blaPDC-438 NG_070204.1 WP_179284377.1 class C beta-lactamase PDC-438 blaPDC-439 NG_070205.1 WP_179284378.1 class C beta-lactamase PDC-439 blaPDC-440 NG_070206.1 WP_179284379.1 class C beta-lactamase PDC-440 blaPDC-441 NG_070207.1 WP_179284380.1 class C beta-lactamase PDC-441 blaPDC-442 NG_070208.1 WP_049305288.1 class C beta-lactamase PDC-442 blaPDC-443 NG_070209.1 WP_132710363.1 class C beta-lactamase PDC-443 blaPDC-444 NG_070210.1 WP_179284381.1 class C beta-lactamase PDC-444 blaPDC-445 NG_070211.1 WP_179284382.1 class C beta-lactamase PDC-445 blaPDC-446 NG_070212.1 WP_179284383.1 class C beta-lactamase PDC-446 blaPDC-447 NG_070213.1 WP_179284384.1 class C beta-lactamase PDC-447 blaPDC-448 NG_070214.1 WP_179284385.1 class C beta-lactamase PDC-448 blaPDC-449 NG_070215.1 WP_179284386.1 class C beta-lactamase PDC-449 blaPDC-450 NG_070216.1 WP_179284387.1 class C beta-lactamase PDC-450 blaPDC-451 NG_070217.1 WP_179284388.1 class C beta-lactamase PDC-451 blaPDC-452 NG_070218.1 WP_179284389.1 class C beta-lactamase PDC-452 blaROB-6 NG_070219.1 WP_179284390.1 class A beta-lactamase ROB-6 blaROB-7 NG_070220.1 WP_179284391.1 class A beta-lactamase ROB-7 blaROB-8 NG_070221.1 WP_179284392.1 class A beta-lactamase ROB-8 blaTEM-228 NG_068038.1 WP_164461302.1 class A beta-lactamase TEM-228 blaVEB-26 NG_070222.1 WP_179284393.1 class A extended-spectrum beta-lactamase VEB-26 blaVIM-71 NG_070223.1 WP_179284394.1 subclass B1 metallo-beta-lactamase VIM-71 mcr-9.3 NG_070224.1 WP_179284395.1 phosphoethanolamine--lipid A transferase MCR-9.3 Changed reference gene catalog records sat AFK88558.1 gene_family: auto-sat -> sat sat CAE55775.1 gene_family: auto-sat -> sat aac(3)-IIg WP_012695485.1 gene_family: aac(3)-II -> aac(3)-IIg product_name: AAC(3)-II family aminoglycoside N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-IIg aph(3')-VIIIb WP_016656536.1 gene_family: aph(3')-VIII -> aph(3')-VIIIb product_name: aminoglycoside O-phosphotransferase APH(3')-VIII -> aminoglycoside O-phosphotransferase APH(3')-VIIIb aph(3')-VIIIa WP_030183523.1 gene_family: aph(3')-VIII -> aph(3')-VIIIa product_name: aminoglycoside O-phosphotransferase APH(3')-VIII -> aminoglycoside O-phosphotransferase APH(3')-VIIIa smr WP_032491400.1 class: MULTIDRUG -> QUATERNARY AMMONIUM subclass: AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM smr WP_063854743.1 class: MULTIDRUG -> QUATERNARY AMMONIUM subclass: AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM smr WP_071846258.1 class: MULTIDRUG -> QUATERNARY AMMONIUM subclass: AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM Added families aac(3)-IIg - aminoglycoside N-acetyltransferase AAC(3)-IIg aph(3')-VIIIa - aminoglycoside O-phosphotransferase APH(3')-VIIIa aph(3')-VIIIb - aminoglycoside O-phosphotransferase APH(3')-VIIIb cfr(E) - 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E) Family changes bla BKC/GPC family carbapenem-hydrolyzing class A beta-lactamase hmm_id: NF033626.1 -> NF033626.2 sat serine protease autotransporter toxin Sat gene_symbol: auto-sat -> sat ---------------------------------------------------------------------- Changes included in 2020-06-11.1 ---------------------------------------------------------------------- Highlights: - Changed the format of the change log below to hopefully make relevant information clearer - Added Staphylococcus aureus AMR point mutations - Added aac(6')-III, a new gene family with HMM and proteins - Cleanup of the GenBank protein accessions and curated_refseq_start fields of the Reference Gene Catalog - Removed GenBank Protein accessions where the start sites don't match the curated start sites - Changed curated_refseq_start from 'Yes' to 'No' where the protein accession points at sequence identical to the refseq protein accession - Some new beta-lactamase alleles Summary counts: Total proteins: 6,376 Core proteins: 5,508 Plus proteins: 868 Point mutations: 682 AMR proteins: 5,536 STRESS proteins: 210 VIRULENCE proteins: 630 Updates since release 2020-05-04.1: Genes added: 10 Core genes added: 10 Plus genes added: 0 Sequences replaced: 1 Core gene sequences replaced: 1 Point mutations added: 38 Other Reference Gene Catalog changes: 116 Families added: 1 Families changed: 1 Core genes added Added blaLEN-27 NG_068509.1 WP_008804981.1 class A beta-lactamase LEN-27 Added aac(6')-III NG_068500.1 WP_010107623.1 tobramycin N-acetyltransferase AAC(6')-III Added aac(6')-III NG_068502.1 WP_038726674.1 tobramycin N-acetyltransferase AAC(6')-III Added aac(6')-III NG_068501.1 WP_038790798.1 tobramycin N-acetyltransferase AAC(6')-III Added NG_052372.1 WP_071846307.1 bifunctional putative esterase EstX/streptothricin N-acetyltransferase Sat1 Added blaCTX-M-236 NG_068506.1 WP_156658722.1 class A extended-spectrum beta-lactamase CTX-M-236 Added blaBKC-2 NG_068505.1 WP_171476787.1 carbapenem-hydrolyzing class A beta-lactamase BKC-2 Added blaKPC-50 NG_068507.1 WP_171476788.1 inhibitor-resistant class A beta-lactamase KPC-50 Added blaKPC-57 NG_068508.1 WP_171476789.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-57 Added blaOXA-916 NG_068510.1 WP_171476790.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-916 Core gene sequences replaced Replaced blaB-6 NG_048700.1 WP_059345632.1 subclass B1 metallo-beta-lactamase BlaB-6 with blaB-6 NG_068504.1 WP_068791546.1 subclass B1 metallo-beta-lactamase BlaB-6 Point mutations added Added 23S_A2531G LINEZOLID Staphylococcus_aureus Added 23S_C2220T LINEZOLID Staphylococcus_aureus Added 23S_G2475T LINEZOLID Staphylococcus_aureus Added 23S_G2533A LINEZOLID Staphylococcus_aureus Added 23S_G2794T LINEZOLID Staphylococcus_aureus Added 23S_T2528A LINEZOLID Staphylococcus_aureus Added 23S_T2532C LINEZOLID Staphylococcus_aureus Added fusA_A376V FUSIDIC ACID Staphylococcus_aureus Added fusA_D373N FUSIDIC ACID Staphylococcus_aureus Added fusA_D387I FUSIDIC ACID Staphylococcus_aureus Added fusA_I449K FUSIDIC ACID Staphylococcus_aureus Added fusA_V607I FUSIDIC ACID Staphylococcus_aureus Added gyrA_D73G QUINOLONE Staphylococcus_aureus Added gyrA_E88R QUINOLONE Staphylococcus_aureus Added gyrA_G82C QUINOLONE Staphylococcus_aureus Added gyrA_S84V QUINOLONE Staphylococcus_aureus Added gyrB_D436N QUINOLONE Staphylococcus_aureus Added gyrB_E476D QUINOLONE Staphylococcus_aureus Added ileS_F563L MUPIROCIN Staphylococcus_aureus Added ileS_G593V MUPIROCIN Staphylococcus_aureus Added ileS_H67Q MUPIROCIN Staphylococcus_aureus Added ileS_R816C MUPIROCIN Staphylococcus_aureus Added parC_A116V QUINOLONE Staphylococcus_aureus Added parE_D432V QUINOLONE Staphylococcus_aureus Added parE_D443E QUINOLONE Staphylococcus_aureus Added parE_P451S QUINOLONE Staphylococcus_aureus Added parE_R444S QUINOLONE Staphylococcus_aureus Added rplC_G139R LINEZOLID Staphylococcus_aureus Added rplC_G152D LINEZOLID Staphylococcus_aureus Added rplC_G155R LINEZOLID Staphylococcus_aureus Added rplC_M169L LINEZOLID Staphylococcus_aureus Added rplC_S145DEL LINEZOLID Staphylococcus_aureus Added rpoB_A477G RIFAMPIN Staphylococcus_aureus Added rpoB_Q468I RIFAMPIN Staphylococcus_aureus Added rpoB_Q468L RIFAMPIN Staphylococcus_aureus Added rpoB_Q468R RIFAMPIN Staphylococcus_aureus Added rpoB_R484C RIFAMPIN Staphylococcus_aureus Added rpoB_S463N RIFAMPIN Staphylococcus_aureus Other changes in the Reference Gene Catalog: Changed 16S_T1406A NC_000913.3 class: AMINGLYCOSIDE -> AMINOGLYCOSIDE Changed aac(3)-VIa WP_000131886.1 genbank_protein_accession: ABF67772.1 -> Changed tet(A) WP_000804063.1 genbank_protein_accession: AAN06707.1 -> Changed aacA57-2 WP_000959805.1 genbank_protein_accession: CAM88403.1 -> Changed qnrB6 WP_001749994.1 genbank_protein_accession: ABP87778.1 -> Changed cmlA5 WP_012300772.1 curated_refseq_start: Yes -> No Changed qnrB1 WP_014386481.1 curated_refseq_start: Yes -> No Changed aac(3)-Ia WP_022542381.1 genbank_protein_accession: AAB20441.1 -> Changed blaCARB-23 WP_025442943.1 genbank_protein_accession: AHJ02283.1 -> Changed blaCARB-21 WP_025632811.1 genbank_protein_accession: AGQ93789.1 -> Changed blaALI-1 WP_026025287.1 genbank_protein_accession: CAQ78899.1 -> Changed dfrA25 WP_029391998.1 genbank_protein_accession: ABB71176.1 -> Changed tet(31) WP_031204920.1 genbank_protein_accession: CAC80727.1 -> Changed blaGOB-39 WP_031257659.1 genbank_protein_accession: EQB91719.1 -> Changed aac(3)-Ia WP_032492247.1 curated_refseq_start: Yes -> No Changed qnrB18 WP_032941855.1 genbank_protein_accession: CAP45903.1 -> Changed qnrB30 WP_032944434.1 genbank_protein_accession: ADM52194.1 -> Changed qnrB12 WP_038640920.1 genbank_protein_accession: CAO82104.1 -> Changed erm(44)v WP_041079981.1 genbank_protein_accession: CUU67654.1 -> Changed blaSGM-2 WP_041385949.1 genbank_protein_accession: BAI97006.1 -> Changed aacA47 WP_041550454.1 genbank_protein_accession: AFY97005.1 -> Changed catA13 WP_043774378.1 genbank_protein_accession: ABO92401.1 -> Changed blaGOB-42 WP_047034183.1 genbank_protein_accession: AKH95462.1 -> Changed qnrB3 WP_047731800.1 curated_refseq_start: Yes -> No Changed erm(42) WP_052259183.1 genbank_protein_accession: BAJ34818.1 -> Changed sul1 WP_058685609.1 genbank_protein_accession: ACO54027.1 -> Changed aac(3)-IId WP_063840265.1 gene_family: aac(3)-IIa -> aac(3)-IId product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IId Changed aac(6')-Ib WP_063840281.1 genbank_protein_accession: AAA26550.1 -> Changed aac(6')-Ib WP_063840282.1 genbank_protein_accession: AAB88285.1 -> Changed aac(6')-Ib WP_063840283.1 genbank_protein_accession: AAK51920.1 -> Changed aac(6')-Ib WP_063840319.1 genbank_protein_accession: AAT70791.1 -> Changed aac(6')-Ib-cr6 WP_063840320.1 genbank_protein_accession: ACD56150.1 -> Changed aadA6 WP_063840454.1 genbank_protein_accession: CBM56270.1 -> Changed arr WP_063842207.1 genbank_protein_accession: CAR63501.1 -> Changed cmlV WP_063844229.1 genbank_protein_accession: AAB36568.1 -> Changed dfrB1 WP_063844476.1 genbank_protein_accession: CAQ52800.1 -> Changed sul1 WP_063855103.1 genbank_protein_accession: ACF06164.1 -> Changed tet(Q) WP_063856408.1 genbank_protein_accession: AAB51122.1 -> Changed tet(Q) WP_063856409.1 genbank_protein_accession: AAZ79478.1 -> Changed blaCARB-3 WP_063859105.1 genbank_protein_accession: AAB19430.2 -> Changed blaCMY-59 WP_063859852.1 genbank_protein_accession: BAJ17544.1 -> Changed qnrB14 WP_063865791.1 genbank_protein_accession: ABX72044.1 -> Changed qnrB15 WP_063865798.1 genbank_protein_accession: ABX72227.1 -> Changed qnrB16 WP_063865802.1 genbank_protein_accession: ABV66096.1 -> Changed qnrB20 WP_063865914.1 genbank_protein_accession: BAG55487.1 -> Changed qnrB23 WP_063865948.1 genbank_protein_accession: ACS71747.1 -> Changed qnrB24 WP_063865960.1 genbank_protein_accession: ADI46626.1 -> Changed qnrB26 WP_063865978.1 genbank_protein_accession: AEH59666.1 -> Changed qnrB31 WP_063866022.1 genbank_protein_accession: ADQ43424.1 -> Changed qnrB40 WP_063866081.1 genbank_protein_accession: AEL31271.1 -> Changed qnrB41 WP_063866087.1 genbank_protein_accession: AEL31272.1 -> Changed qnrB43 WP_063866099.1 genbank_protein_accession: AFA52643.1 -> Changed qnrB44 WP_063866105.1 genbank_protein_accession: AFA52645.1 -> Changed qnrB45 WP_063866109.1 genbank_protein_accession: AFA52644.1 -> Changed qnrB46 WP_063866119.1 genbank_protein_accession: AFA52646.1 -> Changed qnrB49 WP_063866135.1 genbank_protein_accession: AFD54601.1 -> Changed qnrB5 WP_063866143.1 curated_refseq_start: Yes -> No Changed qnrB53 WP_063866162.1 genbank_protein_accession: ADW54092.1 -> Changed qnrB56 WP_063866184.1 genbank_protein_accession: AFR46587.1 -> Changed qnrB57 WP_063866188.1 genbank_protein_accession: AFR46588.1 -> Changed qnrB58 WP_063866193.1 genbank_protein_accession: AFR46589.1 -> Changed qnrB59 WP_063866199.1 genbank_protein_accession: AFR46590.1 -> Changed qnrB62 WP_063866224.1 genbank_protein_accession: AFY16910.1 -> Changed kamB WP_063964000.1 genbank_protein_accession: P25920.2 -> Changed kamB WP_063964001.1 genbank_protein_accession: Q2MEY3.2 -> Changed sgm WP_063978071.1 genbank_protein_accession: Q7M0R2.1 -> Changed tet(Z) WP_064190967.1 genbank_protein_accession: AAD25063.1 -> Changed aac(6')-29a WP_064190968.1 genbank_protein_accession: AAK26252.2 -> Changed aac(6')-29b WP_064190969.1 genbank_protein_accession: AAK26254.2 -> Changed aac(6')-Ib WP_065187201.1 genbank_protein_accession: KVJ45508.1 -> Changed aac(6')-Ip WP_069453146.1 genbank_protein_accession: CAA91010.1 -> Changed blaFAR-1 WP_070064531.1 genbank_protein_accession: AAB81957.1 -> Changed vanS WP_070064533.1 genbank_protein_accession: AHA41504.1 -> Changed aac(6')-If WP_071593229.1 genbank_protein_accession: CAA39038.1 -> Changed aac(6')-Ib-cr7 WP_071766399.1 genbank_protein_accession: AMX43335.1 -> Changed blaMSI-1 WP_071766402.1 genbank_protein_accession: AJP77057.1 -> Changed aac(6')-Ib-cr3 WP_071766621.1 genbank_protein_accession: ADY02579.1 -> Changed arr-3 WP_071846202.1 genbank_protein_accession: AHN09978.1 -> Changed aac(6')-Ib WP_071846208.1 genbank_protein_accession: KDI62549.1 -> Changed aac(6')-Ib WP_071846209.1 genbank_protein_accession: KDK90399.1 -> Changed aac(6')-Ib-cr WP_071846215.1 genbank_protein_accession: ALM55696.1 -> Changed aac(6')-Ib WP_071846249.1 genbank_protein_accession: CBI63204.2 -> Changed aac(6')-Ib WP_071846291.1 genbank_protein_accession: CBL95256.1 -> Changed qacF WP_071846292.1 genbank_protein_accession: CBM06475.1 -> Changed aadA6 WP_071846297.1 genbank_protein_accession: CBM56264.1 -> Changed aadA6 WP_071846298.1 genbank_protein_accession: CBM56266.1 -> Changed blaPSE WP_071846358.1 genbank_protein_accession: ABM92282.1 -> Changed ant(2'')-Ia WP_071846368.1 genbank_protein_accession: AEH59672.1 -> Changed blmA WP_072081991.1 genbank_protein_accession: EME99227.1 -> Changed blaGOB-47 WP_073552023.1 curated_refseq_start: Yes -> No Changed blaB-34 WP_078678782.1 genbank_protein_accession: OPC54933.1 -> Changed blaB-27 WP_078772815.1 genbank_protein_accession: OPC62103.1 -> Changed blaB-39 WP_078778510.1 genbank_protein_accession: OPB88934.1 -> Changed aac(3)-Ib WP_079459897.1 genbank_protein_accession: ADU90742.1 -> Changed blaB-36 WP_080889626.1 genbank_protein_accession: AJW65208.1 -> Changed blaB-29 WP_081318900.1 genbank_protein_accession: KUF46169.1 -> Changed blaOXA-671 WP_081401608.1 genbank_protein_accession: EPF93312.1 -> Changed mcr-1.9 WP_099982800.1 curated_refseq_start: Yes -> No Changed blaBUT-2 WP_104531864.1 genbank_protein_accession: AAN17791.1 -> Changed blaB-28 WP_107808007.1 genbank_protein_accession: PTW04273.1 -> Changed tet(S) WP_109544237.1 genbank_protein_accession: AAT02170.1 -> Changed dfrA14 WP_109545031.1 genbank_protein_accession: ABD46710.1 -> Changed qnrB11 WP_109545032.1 genbank_protein_accession: ABS30107.1 -> Changed vanY-D WP_109545033.1 genbank_protein_accession: ACM47285.1 -> Changed qnrB22 WP_109545034.1 genbank_protein_accession: ACS71746.1 -> Changed qacF WP_109545035.1 genbank_protein_accession: AHN60087.1 -> Changed tet(33) WP_109545038.1 genbank_protein_accession: ABG49357.1 -> Changed blaSTA-1 WP_109545039.1 genbank_protein_accession: EAU66413.1 -> Changed aph(3'')-Ib WP_109545041.1 genbank_protein_accession: ACF57076.1 -> Changed blaORR-1 WP_109545042.1 genbank_protein_accession: AFL96616.1 -> Changed blaECM-1 WP_122630824.1 genbank_protein_accession: AFN85387.1 -> Changed aac(6')-Ib WP_140423191.1 genbank_protein_accession: CCF72268.1 -> Changed aadA2 WP_140423281.1 genbank_protein_accession: CCP09091.1 -> Changed blaKPC-53 WP_156649232.1 curated_refseq_start: Yes -> No Changed blaCVI-1 WP_164461288.1 genbank_protein_accession: QHN71476.1 -> Changed blaYRC-1 WP_168370989.1 product_name: YRC family class C beta-lactamase YRC-1 -> class C beta-lactamase YRC-1 Families added Added family NF038102.1 aac(6')-III Families changed Updated family NF033088.1 bla-B1 to NF033088.2 bla-B1 ---------------------------------------------------------------------- Changes included in 2020-05-04.1 ---------------------------------------------------------------------- This update includes a change to the database format. It is compatible with AMRFinderPlus versions in the 3.8 series. You will need to upgrade your software to version 3.8 to use this database. The reason for changing the database format is part of a larger NCBI directive to move from using GIs to accessions as the primary identifier for sequences. If that doesn't mean much to you it's ok. AMRFinderPlus should work in the same way it did before. Summary of other changes: - Updated sequence for blaB-27 and blaB-34 to include two methionines at 5' start - Fixed partial blaGOB-42 - We added GenBank accesions to many existing reference genes where previously there was a missing value - Continued curation of new genes and alleles - Reference Gene Catalog Changes Added: 64 Removed: 0 Changed: 123 Proteins added: 64 NG_ records added: 62 Total proteins: 6366 Total mutations: 644 Total NG_ records: 5498 Total: 7010 Added cdtB AAT92048.1 cytolethal distending toxin type IV nuclease subunit CdtB Added cdtB BAF63361.1 cytolethal distending toxin type I nuclease subunit CdtB Added blaOXA-914 NG_068185.1 WP_023132404.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-914 Added blaOXA-913 NG_068184.1 WP_031691948.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-913 Added mcr-1.26 NG_068217.1 WP_034169413.1 phosphoethanolamine--lipid A transferase MCR-1.26 Added blaOXA-912 NG_068183.1 WP_040068451.1 OXA-12 family class D beta-lactamase OXA-912 Added blaOXA-543 NG_068179.1 WP_058132644.1 OXA-2 family class D beta-lactamase OXA-543 Added blaCTX-M-140 NG_068166.1 WP_063108644.1 class A extended-spectrum beta-lactamase CTX-M-140 Added blaOXA-498 NG_068178.1 WP_063454569.1 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-498 Added catA1 NG_047584.1 WP_063843217.1 type A-1 chloramphenicol O-acetyltransferase Added blaSHV-171 NG_068212.1 WP_070984444.1 class A broad-spectrum beta-lactamase SHV-171 Added blaOXA-544 NG_068180.1 WP_071537493.1 OXA-2 family class D beta-lactamase OXA-544 Added blaACT-84 NG_068161.1 WP_072139974.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-84 Added blaGOB-47 NG_068223.1 WP_073552023.1 subclass B3 metallo-beta-lactamase GOB-47 Added blaGOB-28 NG_068171.1 WP_087093762.1 subclass B3 metallo-beta-lactamase GOB-28 Added blaB-30 NG_068164.1 WP_087094142.1 subclass B1 metallo-beta-lactamase BlaB-30 Added blaGOB-45 NG_068172.1 WP_102793805.1 subclass B3 metallo-beta-lactamase GOB-45 Added blaTEM-7 NG_068216.1 WP_109874025.1 class A extended-spectrum beta-lactamase TEM-7 Added blaTEM-5 NG_068215.1 WP_109963600.1 class A extended-spectrum beta-lactamase TEM-5 Added blaSHV-116 NG_068211.1 WP_117062210.1 class A beta-lactamase SHV-116 Added blaPDC-407 NG_068195.1 WP_124187209.1 class C beta-lactamase PDC-407 Added blaPDC-402 NG_068190.1 WP_134265631.1 class C beta-lactamase PDC-402 Added blaPDC-408 NG_068196.1 WP_134450540.1 class C beta-lactamase PDC-408 Added qnrVC9 NG_068219.1 WP_148560450.1 quinolone resistance pentapeptide repeat protein QnrVC9 Added blaACT-86 NG_068163.1 WP_152819218.1 ceftazidime-hydrolyzing class C beta-lactamase ACT-86 Added blaACT-85 NG_068162.1 WP_154123408.1 ceftazidime-hydrolyzing class C beta-lactamase ACT-85 Added blaKPC-53 NG_068176.1 WP_156649232.1 carbapenem-hydrolyzing class A beta-lactamase KPC-53 Added blaTEM-37 NG_068214.1 WP_159373457.1 inhibitor-resistant class A broad-spectrum beta-lactamase TEM-37 Added blaOXA-909 NG_068181.1 WP_162278338.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-909 Added mcr-1.27 NG_068218.1 WP_163397051.1 phosphoethanolamine--lipid A transferase MCR-1.27 Added blaTEM-31 NG_068213.1 WP_165539487.1 inhibitor-resistant class A broad-spectrum beta-lactamase TEM-31 Added blaCMY-171 NG_068165.1 WP_168247875.1 class C beta-lactamase CMY-171 Added blaCTX-M-153 NG_068167.1 WP_168247876.1 class A extended-spectrum beta-lactamase CTX-M-153 Added blaCTX-M-234 NG_068168.1 WP_168247877.1 class A extended-spectrum beta-lactamase CTX-M-234 Added blaCTX-M-235 NG_068169.1 WP_168247878.1 class A extended-spectrum beta-lactamase CTX-M-235 Added blaFOX-17 NG_068170.1 WP_168247879.1 cephalosporin-hydrolyzing class C beta-lactamase FOX-17 Added blaIDC-1 NG_068174.1 WP_168247881.1 class C beta-lactamase IDC-1 Added blaIDC-2 NG_068175.1 WP_168247882.1 class C beta-lactamase IDC-2 Added blaKPC-55 NG_068177.1 WP_168247883.1 carbapenem-hydrolyzing class A beta-lactamase KPC-55 Added blaOXA-911 NG_068182.1 WP_168247884.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-911 Added blaPDC-398 NG_068186.1 WP_168247885.1 class C beta-lactamase PDC-398 Added blaPDC-399 NG_068187.1 WP_168247886.1 class C beta-lactamase PDC-399 Added blaPDC-400 NG_068188.1 WP_168247887.1 class C beta-lactamase PDC-400 Added blaPDC-401 NG_068189.1 WP_168247888.1 class C beta-lactamase PDC-401 Added blaPDC-403 NG_068191.1 WP_168247889.1 class C beta-lactamase PDC-403 Added blaPDC-404 NG_068192.1 WP_168247890.1 class C beta-lactamase PDC-404 Added blaPDC-405 NG_068193.1 WP_168247891.1 class C beta-lactamase PDC-405 Added blaPDC-406 NG_068194.1 WP_168247892.1 class C beta-lactamase PDC-406 Added blaPDC-409 NG_068197.1 WP_168247893.1 class C beta-lactamase PDC-409 Added blaPDC-410 NG_068198.1 WP_168247894.1 class C beta-lactamase PDC-410 Added blaPDC-411 NG_068199.1 WP_168247895.1 class C beta-lactamase PDC-411 Added blaPDC-412 NG_068200.1 WP_168247896.1 class C beta-lactamase PDC-412 Added blaPDC-413 NG_068201.1 WP_168247897.1 class C beta-lactamase PDC-413 Added blaPDC-414 NG_068202.1 WP_168247898.1 class C beta-lactamase PDC-414 Added blaPDC-415 NG_068203.1 WP_168247899.1 class C beta-lactamase PDC-415 Added blaPDC-416 NG_068204.1 WP_168247900.1 class C beta-lactamase PDC-416 Added blaPDC-417 NG_068205.1 WP_168247901.1 class C beta-lactamase PDC-417 Added blaPDC-418 NG_068206.1 WP_168247902.1 class C beta-lactamase PDC-418 Added blaPDC-419 NG_068207.1 WP_168247903.1 class C beta-lactamase PDC-419 Added blaPDC-420 NG_068208.1 WP_168247904.1 class C beta-lactamase PDC-420 Added blaPDC-421 NG_068209.1 WP_168247905.1 class C beta-lactamase PDC-421 Added blaPER-15 NG_068210.1 WP_168247906.1 class A extended-spectrum beta-lactamase PER-15 Added blaOXA-915 NG_068224.1 WP_168370988.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-915 Added blaYRC-1 NG_068225.1 WP_168370989.1 YRC family class C beta-lactamase YRC-1 Changes: Changed blaB-27 refseq_protein_accession: WP_164461286.1 -> WP_078772815.1 refseq_nucleotide_accession: NG_067980.1 -> NG_067980.2 curated_refseq_start: No -> Yes genbank_cds_stop: 343052 -> 343055 Changed blaB-34 refseq_protein_accession: WP_164461287.1 -> WP_078678782.1 refseq_nucleotide_accession: NG_067983.1 -> NG_067983.2 curated_refseq_start: No -> Yes genbank_cds_stop: 202987 -> 202990 Changed blaGOB-42 refseq_protein_accession: WP_164461289.1 -> WP_047034183.1 refseq_nucleotide_accession: NG_068008.1 -> NG_068008.2 curated_refseq_start: No -> Yes genbank_cds_stop: 2742885 -> 2742924 Changed iroE genbank_protein_accession: YP_002527501.1 -> ACJ63530.1 genbank_nucleotide_accession: -> CP001232.1 genbank_strand_orientation: - -> + genbank_cds_start: -> 43893 genbank_cds_stop: -> 44849 Changed aac(3)-VIa WP_000131886.1 genbank_protein_accession: -> ABF67772.1 Changed tet(A) WP_000804063.1 genbank_protein_accession: -> AAN06707.1 Changed aacA57-2 WP_000959805.1 genbank_protein_accession: -> CAM88403.1 Changed qnrB6 WP_001749994.1 genbank_protein_accession: -> ABP87778.1 Changed aac(3)-Ia WP_022542381.1 genbank_protein_accession: -> AAB20441.1 Changed blaCARB-23 WP_025442943.1 genbank_protein_accession: -> AHJ02283.1 Changed blaCARB-21 WP_025632811.1 genbank_protein_accession: -> AGQ93789.1 Changed blaALI-1 WP_026025287.1 genbank_protein_accession: -> CAQ78899.1 Changed dfrA25 WP_029391998.1 genbank_protein_accession: -> ABB71176.1 Changed tet(31) WP_031204920.1 genbank_protein_accession: -> CAC80727.1 Changed blaGOB-39 WP_031257659.1 genbank_protein_accession: -> EQB91719.1 Changed qnrB18 WP_032941855.1 genbank_protein_accession: -> CAP45903.1 Changed qnrB30 WP_032944434.1 genbank_protein_accession: -> ADM52194.1 Changed qnrB12 WP_038640920.1 genbank_protein_accession: -> CAO82104.1 Changed erm(44)v WP_041079981.1 genbank_protein_accession: -> CUU67654.1 Changed blaSGM-2 WP_041385949.1 genbank_protein_accession: -> BAI97006.1 Changed aacA47 WP_041550454.1 genbank_protein_accession: -> AFY97005.1 Changed catA13 WP_043774378.1 genbank_protein_accession: -> ABO92401.1 Changed erm(42) WP_052259183.1 genbank_protein_accession: -> BAJ34818.1 Changed sul1 WP_058685609.1 genbank_protein_accession: -> ACO54027.1 Changed aac(6')-Ib WP_063840281.1 genbank_protein_accession: -> AAA26550.1 Changed aac(6')-Ib WP_063840282.1 genbank_protein_accession: -> AAB88285.1 Changed aac(6')-Ib WP_063840283.1 genbank_protein_accession: -> AAK51920.1 Changed aac(6')-Ib WP_063840319.1 genbank_protein_accession: -> AAT70791.1 Changed aac(6')-Ib-cr6 WP_063840320.1 genbank_protein_accession: -> ACD56150.1 Changed aadA6 WP_063840454.1 genbank_protein_accession: -> CBM56270.1 Changed arr WP_063842207.1 genbank_protein_accession: -> CAR63501.1 Changed cmlV WP_063844229.1 genbank_protein_accession: -> AAB36568.1 Changed dfrB1 WP_063844476.1 genbank_protein_accession: -> CAQ52800.1 Changed sul1 WP_063855103.1 genbank_protein_accession: -> ACF06164.1 Changed tet(Q) WP_063856408.1 genbank_protein_accession: -> AAB51122.1 Changed tet(Q) WP_063856409.1 genbank_protein_accession: -> AAZ79478.1 Changed blaCARB-3 WP_063859105.1 genbank_protein_accession: -> AAB19430.2 Changed blaCMY-59 WP_063859852.1 genbank_protein_accession: -> BAJ17544.1 Changed qnrB14 WP_063865791.1 genbank_protein_accession: -> ABX72044.1 Changed qnrB15 WP_063865798.1 genbank_protein_accession: -> ABX72227.1 Changed qnrB16 WP_063865802.1 genbank_protein_accession: -> ABV66096.1 Changed qnrB20 WP_063865914.1 genbank_protein_accession: -> BAG55487.1 Changed qnrB23 WP_063865948.1 genbank_protein_accession: -> ACS71747.1 Changed qnrB24 WP_063865960.1 genbank_protein_accession: -> ADI46626.1 Changed qnrB26 WP_063865978.1 genbank_protein_accession: -> AEH59666.1 Changed qnrB31 WP_063866022.1 genbank_protein_accession: -> ADQ43424.1 Changed qnrB40 WP_063866081.1 genbank_protein_accession: -> AEL31271.1 Changed qnrB41 WP_063866087.1 genbank_protein_accession: -> AEL31272.1 Changed qnrB43 WP_063866099.1 genbank_protein_accession: -> AFA52643.1 Changed qnrB44 WP_063866105.1 genbank_protein_accession: -> AFA52645.1 Changed qnrB45 WP_063866109.1 genbank_protein_accession: -> AFA52644.1 Changed qnrB46 WP_063866119.1 genbank_protein_accession: -> AFA52646.1 Changed qnrB49 WP_063866135.1 genbank_protein_accession: -> AFD54601.1 Changed qnrB53 WP_063866162.1 genbank_protein_accession: -> ADW54092.1 Changed qnrB56 WP_063866184.1 genbank_protein_accession: -> AFR46587.1 Changed qnrB57 WP_063866188.1 genbank_protein_accession: -> AFR46588.1 Changed qnrB58 WP_063866193.1 genbank_protein_accession: -> AFR46589.1 Changed qnrB59 WP_063866199.1 genbank_protein_accession: -> AFR46590.1 Changed qnrB62 WP_063866224.1 genbank_protein_accession: -> AFY16910.1 Changed kamB WP_063964000.1 genbank_protein_accession: -> P25920.2 Changed kamB WP_063964001.1 genbank_protein_accession: -> Q2MEY3.2 Changed sgm WP_063978071.1 genbank_protein_accession: -> Q7M0R2.1 Changed tet(Z) WP_064190967.1 genbank_protein_accession: -> AAD25063.1 Changed aac(6')-29a WP_064190968.1 genbank_protein_accession: -> AAK26252.2 Changed aac(6')-29b WP_064190969.1 genbank_protein_accession: -> AAK26254.2 Changed aac(6')-Ib WP_065187201.1 genbank_protein_accession: -> KVJ45508.1 Changed aac(6')-Ip WP_069453146.1 genbank_protein_accession: -> CAA91010.1 Changed blaFAR-1 WP_070064531.1 genbank_protein_accession: -> AAB81957.1 Changed vanS WP_070064533.1 genbank_protein_accession: -> AHA41504.1 Changed aac(6')-If WP_071593229.1 genbank_protein_accession: -> CAA39038.1 Changed aac(6')-Ib-cr7 WP_071766399.1 genbank_protein_accession: -> AMX43335.1 Changed blaMSI-1 WP_071766402.1 genbank_protein_accession: -> AJP77057.1 Changed aac(6')-Ib-cr3 WP_071766621.1 genbank_protein_accession: -> ADY02579.1 Changed arr-3 WP_071846202.1 genbank_protein_accession: -> AHN09978.1 Changed aac(6')-Ib WP_071846208.1 genbank_protein_accession: -> KDI62549.1 Changed aac(6')-Ib WP_071846209.1 genbank_protein_accession: -> KDK90399.1 Changed aac(6')-Ib-cr WP_071846215.1 genbank_protein_accession: -> ALM55696.1 Changed aac(6')-Ib WP_071846249.1 genbank_protein_accession: -> CBI63204.2 Changed aac(6')-Ib WP_071846291.1 genbank_protein_accession: -> CBL95256.1 Changed qacF WP_071846292.1 genbank_protein_accession: -> CBM06475.1 Changed aadA6 WP_071846297.1 genbank_protein_accession: -> CBM56264.1 Changed aadA6 WP_071846298.1 genbank_protein_accession: -> CBM56266.1 Changed blaPSE WP_071846358.1 genbank_protein_accession: -> ABM92282.1 Changed ant(2'')-Ia WP_071846368.1 genbank_protein_accession: -> AEH59672.1 Changed blmA WP_072081991.1 genbank_protein_accession: -> EME99227.1 Changed blaB-39 WP_078778510.1 genbank_protein_accession: -> OPB88934.1 Changed aac(3)-Ib WP_079459897.1 genbank_protein_accession: -> ADU90742.1 Changed blaB-36 WP_080889626.1 genbank_protein_accession: -> AJW65208.1 Changed blaB-29 WP_081318900.1 genbank_protein_accession: -> KUF46169.1 Changed blaOXA-671 WP_081401608.1 genbank_protein_accession: -> EPF93312.1 Changed icr-Mo WP_082741435.1 genbank_protein_accession: WP_082741435.1 -> refseq_protein_accession: -> WP_082741435.1 Changed blaBUT-2 WP_104531864.1 genbank_protein_accession: -> AAN17791.1 Changed blaB-28 WP_107808007.1 genbank_protein_accession: -> PTW04273.1 Changed tet(S) WP_109544237.1 genbank_protein_accession: -> AAT02170.1 Changed dfrA14 WP_109545031.1 genbank_protein_accession: -> ABD46710.1 Changed qnrB11 WP_109545032.1 genbank_protein_accession: -> ABS30107.1 Changed vanY-D WP_109545033.1 genbank_protein_accession: -> ACM47285.1 Changed qnrB22 WP_109545034.1 genbank_protein_accession: -> ACS71746.1 Changed qacF WP_109545035.1 genbank_protein_accession: -> AHN60087.1 Changed tet(33) WP_109545038.1 genbank_protein_accession: -> ABG49357.1 Changed blaSTA-1 WP_109545039.1 genbank_protein_accession: -> EAU66413.1 Changed aph(3'')-Ib WP_109545041.1 genbank_protein_accession: -> ACF57076.1 Changed blaORR-1 WP_109545042.1 genbank_protein_accession: -> AFL96616.1 Changed blaECM-1 WP_122630824.1 genbank_protein_accession: -> AFN85387.1 Changed aac(6')-Ib WP_140423191.1 genbank_protein_accession: -> CCF72268.1 Changed aadA2 WP_140423281.1 genbank_protein_accession: -> CCP09091.1 Changed blaACT-73 WP_152315464.1 genbank_nucleotide_accession: KJ949129.1 -> KJ949129.2 refseq_nucleotide_accession: NG_066689.1 -> NG_066689.2 Changed blaCVI-1 WP_164461288.1 genbank_protein_accession: -> QHN71476.1 Changed parE_D475E WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_D476N WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_E460D WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_E460K WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_G423R WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_I355T WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_I444F WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_I464F WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_I470M WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_I529L WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_L416F WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_L445H WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_P439S WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_S458A WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 Changed parE_S458T WP_033554192.1 genbank_protein_accession: EAA4575386.1 -> RRN00056.1 - AMR HMM library Changes: Total: Added 1 Total: Prev. Release 625 Total: Removed 0 Total: This Release 626 HMM Added: NF038089.1 blaYRC-NCBI - Protein family changes: Total: Added 3 Total: Prev. Release 1567 Total: Removed 0 Total: This Release 1570 Family Added: NF038089.1 blaYRC Family Added: - cdtB_I Family Added: - cdtB_IV ---------------------------------------------------------------------- Changes included in 2020-03-20.1 ---------------------------------------------------------------------- Summary of changes: - Added curated Staphylococcus aureus SNPs - Reorganization and extensive curation of aac(6')-Ib with updates for specific drug resistance information where site-specific dependencies are known - Removal of a few protein sequences that were found to be incomplete - Blacklisting --organism option for Staphylococcus pseudintermedius changed to --organism=Staphylococcus_pseudintermedius - Added --organism=Staphylococcus_aureus for Staph. aureus SNPs - Several new HMMs added - Reference Gene Catalog Changes Added: 278 Removed: 4 Changed: 60 Total proteins: 6302 Total mutations: 644 Total: 6946 Removed mchF AAX22079.2 microcin H47 export transporter peptidase/ATP-binding subunit MchF Removed mchF AFQ65076.1 microcin H47 export transporter peptidase/ATP-binding subunit MchF Removed chrR BAA11821.1 class I chromate reductase ChrR Removed aac(3)-IVa WP_063840268.1 aminoglycoside N-acetyltransferase AAC(3)-IVa Added 23S_C2579T LINEZOLID Staphylococcus_aureus Added 23S_G2577T LINEZOLID Staphylococcus_aureus Added 23S_G2604T LINEZOLID Staphylococcus_aureus Added 23S_T2501A LINEZOLID Staphylococcus_aureus Added almG AAF94731.1 glycine--lipid A transferase AlmG Added abaF ABO11759.2 fosfomycin efflux MFS transporter AbaF Added papF CAA43569.1 P fimbrial tip protein PapF Added blaOXA-904 WP_003122322.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-904 Added blaOXA-905 WP_003161096.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-905 Added blaGOB-20 WP_009089555.1 subclass B3 metallo-beta-lactamase GOB-20 Added blaGOB-22 WP_019050927.1 subclass B3 metallo-beta-lactamase GOB-22 Added blaGOB-21 WP_024566153.1 subclass B3 metallo-beta-lactamase GOB-21 Added blaGOB-26 WP_024567831.1 subclass B3 metallo-beta-lactamase GOB-26 Added blaOXA-902 WP_024916334.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-902 Added blaGOB-39 WP_031257659.1 subclass B3 metallo-beta-lactamase GOB-39 Added blaOXA-908 WP_031694184.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-908 Added blaOXA-901 WP_031757092.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-901 Added blaOXA-906 WP_034005326.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-906 Added blaGOB-40 WP_034845394.1 subclass B3 metallo-beta-lactamase GOB-40 Added qnrA10 WP_044735234.1 quinolone resistance pentapeptide repeat protein QnrA10 Added blaGOB-49 WP_045183849.1 subclass B3 metallo-beta-lactamase GOB-49 Added blaGOB-38 WP_058879139.1 subclass B3 metallo-beta-lactamase GOB-38 Added blaGOB-37 WP_059323095.1 subclass B3 metallo-beta-lactamase GOB-37 Added blaGOB-25 WP_059345125.1 subclass B3 metallo-beta-lactamase GOB-25 Added aac(6')-Ib WP_064765190.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added blaGOB-32 WP_065081961.1 subclass B3 metallo-beta-lactamase GOB-32 Added aac(6')-Ib WP_069067473.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added blaGOB-27 WP_069213816.1 subclass B3 metallo-beta-lactamase GOB-27 Added aac(6')-Ib WP_071984682.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(6')-Ib WP_072201103.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added blaGOB-41 WP_078395323.1 subclass B3 metallo-beta-lactamase GOB-41 Added blaGOB-51 WP_078402651.1 subclass B3 metallo-beta-lactamase GOB-51 Added blaGOB-43 WP_078407131.1 subclass B3 metallo-beta-lactamase GOB-43 Added blaGOB-50 WP_078675023.1 subclass B3 metallo-beta-lactamase GOB-50 Added blaGOB-30 WP_078676551.1 subclass B3 metallo-beta-lactamase GOB-30 Added blaGOB-29 WP_078678126.1 subclass B3 metallo-beta-lactamase GOB-29 Added blaGOB-31 WP_078703439.1 subclass B3 metallo-beta-lactamase GOB-31 Added blaGOB-36 WP_078722646.1 subclass B3 metallo-beta-lactamase GOB-36 Added blaGOB-48 WP_078724262.1 subclass B3 metallo-beta-lactamase GOB-48 Added blaGOB-46 WP_078769980.1 subclass B3 metallo-beta-lactamase GOB-46 Added blaB-39 WP_078778510.1 subclass B1 metallo-beta-lactamase BlaB-39 Added blaGOB-35 WP_078779188.1 subclass B3 metallo-beta-lactamase GOB-35 Added blaGOB-44 WP_078793281.1 subclass B3 metallo-beta-lactamase GOB-44 Added blaGOB-23 WP_078795634.1 subclass B3 metallo-beta-lactamase GOB-23 Added blaGOB-33 WP_078797000.1 subclass B3 metallo-beta-lactamase GOB-33 Added aac(6')-Ib WP_079452738.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(3)-Ib WP_079459897.1 aminoglycoside N-acetyltransferase AAC(3)-Ib Added blaB-36 WP_080889626.1 subclass B1 metallo-beta-lactamase BlaB-36 Added blaB-29 WP_081318900.1 subclass B1 metallo-beta-lactamase BlaB-29 Added aac(6')-Ib WP_085843736.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(6')-Ib WP_085844237.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added blaKPC-56 WP_087744800.1 carbapenem-hydrolyzing class A beta-lactamase KPC-56 Added aac(6')-Ib WP_087872512.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added blaGOB-24 WP_101360689.1 subclass B3 metallo-beta-lactamase GOB-24 Added aac(6')-Ib WP_101516660.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(6')-Ib WP_104442471.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added blaB-28 WP_107808007.1 subclass B1 metallo-beta-lactamase BlaB-28 Added blaGOB-34 WP_107809858.1 subclass B3 metallo-beta-lactamase GOB-34 Added aac(6')-Ib WP_113613509.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(6')-Ib WP_117044474.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(6')-Ib WP_117046752.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(6')-Ib WP_117065919.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added tet(W) WP_122634437.1 tetracycline resistance ribosomal protection protein Tet(W) Added aac(6')-Ib WP_123085936.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(6')-Ib-cr10 WP_124042715.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr10 Added aac(6')-Ib WP_126123880.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added blaRSA2-1 WP_128268281.1 carbapenem-hydrolyzing class A beta-lactamase RSA2-1 Added blaRSC1-1 WP_128268282.1 RSC1 family class C beta-lactamase Added blaRSD1-1 WP_128268283.1 RSD1 family class D beta-lactamase Added blaRSD2-1 WP_128268284.1 class D beta-lactamase RSD2-1 Added blaRSD2-2 WP_128268285.1 class D beta-lactamase RSD2-2 Added aac(6')-Ib-cr9 WP_131534982.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr9 Added blaADC-235 WP_132038428.1 class C beta-lactamase ADC-235 Added aac(6')-Ib WP_132629969.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(6')-Ib WP_134628915.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added tet(55) WP_148044404.1 tetracycline destructase Tet(55) Added blaIMP-81 WP_148044415.1 subclass B1 metallo-beta-lactamase IMP-81 Added blaPNGM-1 WP_148044471.1 subclass B3-like metallo-beta-lactamase PNGM-1 Added aac(6')-Ib WP_148937512.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added aac(6')-Ib-cr8 WP_151346866.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr8 Added aac(6')-Ib WP_151405943.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added blaOXA-899 WP_154205474.1 OXA-22 family class D beta-lactamase OXA-899 Added blaOXA-898 WP_154205589.1 OXA-60 family carbapenem-hydrolyzing class D beta-lactamase OXA-898 Added blaADC-234 WP_159162532.1 class C beta-lactamase ADC-234 Added aac(6')-Ib-cr11 WP_159241551.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr11 Added aac(6')-Ib WP_159287722.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Added blaOXA-910 WP_162280230.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-910 Added blaACT-78 WP_164461280.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-78 Added blaACT-79 WP_164461281.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-79 Added blaACT-80 WP_164461282.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-80 Added blaACT-81 WP_164461283.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-81 Added blaACT-82 WP_164461284.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-82 Added blaACT-83 WP_164461285.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-83 Added blaB-27 WP_164461286.1 subclass B1 metallo-beta-lactamase BlaB-27 Added blaB-34 WP_164461287.1 subclass B1 metallo-beta-lactamase BlaB-34 Added blaCVI-1 WP_164461288.1 subclass B2 metallo-beta-lactamase CVI-1 Added blaGOB-42 WP_164461289.1 subclass B3 metallo-beta-lactamase GOB-42 Added blaOXA-897 WP_164461290.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-897 Added blaOXA-903 WP_164461291.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-903 Added blaOXA-907 WP_164461292.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-907 Added blaPDC-389 WP_164461293.1 class C beta-lactamase PDC-389 Added blaPDC-390 WP_164461294.1 class C beta-lactamase PDC-390 Added blaPDC-391 WP_164461295.1 class C beta-lactamase PDC-391 Added blaPDC-392 WP_164461296.1 class C beta-lactamase PDC-392 Added blaPDC-393 WP_164461297.1 class C beta-lactamase PDC-393 Added blaPDC-394 WP_164461298.1 class C beta-lactamase PDC-394 Added blaPDC-395 WP_164461299.1 class C beta-lactamase PDC-395 Added blaPDC-396 WP_164461300.1 class C beta-lactamase PDC-396 Added blaPDC-397 WP_164461301.1 class C beta-lactamase PDC-397 Added blaVIM-70 WP_164461303.1 subclass B1 metallo-beta-lactamase VIM-70 Added blaCMY-136 WP_164924988.1 class C beta-lactamase CMY-136 Added cls_A23V DAPTOMYCIN Staphylococcus_aureus Added cls_F60S DAPTOMYCIN Staphylococcus_aureus Added cls_L52F DAPTOMYCIN Staphylococcus_aureus Added cls_T33N DAPTOMYCIN Staphylococcus_aureus Added dfrB_F99I TRIMETHOPRIM Staphylococcus_aureus Added dfrB_F99S TRIMETHOPRIM Staphylococcus_aureus Added dfrB_F99Y TRIMETHOPRIM Staphylococcus_aureus Added dfrB_H150R TRIMETHOPRIM Staphylococcus_aureus Added dfrB_H31N TRIMETHOPRIM Staphylococcus_aureus Added dfrB_L21V TRIMETHOPRIM Staphylococcus_aureus Added dfrB_L41F TRIMETHOPRIM Staphylococcus_aureus Added dfrB_N60I TRIMETHOPRIM Staphylococcus_aureus Added fusA_A160V FUSIDIC ACID Staphylococcus_aureus Added fusA_A655E FUSIDIC ACID Staphylococcus_aureus Added fusA_A655P FUSIDIC ACID Staphylococcus_aureus Added fusA_A655V FUSIDIC ACID Staphylococcus_aureus Added fusA_C473S FUSIDIC ACID Staphylococcus_aureus Added fusA_D189G FUSIDIC ACID Staphylococcus_aureus Added fusA_D189V FUSIDIC ACID Staphylococcus_aureus Added fusA_D434N FUSIDIC ACID Staphylococcus_aureus Added fusA_D463G FUSIDIC ACID Staphylococcus_aureus Added fusA_E233Q FUSIDIC ACID Staphylococcus_aureus Added fusA_E444K FUSIDIC ACID Staphylococcus_aureus Added fusA_E444V FUSIDIC ACID Staphylococcus_aureus Added fusA_F652S FUSIDIC ACID Staphylococcus_aureus Added fusA_F88L FUSIDIC ACID Staphylococcus_aureus Added fusA_G451V FUSIDIC ACID Staphylococcus_aureus Added fusA_G452C FUSIDIC ACID Staphylococcus_aureus Added fusA_G452S FUSIDIC ACID Staphylococcus_aureus Added fusA_G452V FUSIDIC ACID Staphylococcus_aureus Added fusA_G556S FUSIDIC ACID Staphylococcus_aureus Added fusA_G617D FUSIDIC ACID Staphylococcus_aureus Added fusA_G664S FUSIDIC ACID Staphylococcus_aureus Added fusA_H438N FUSIDIC ACID Staphylococcus_aureus Added fusA_H457Q FUSIDIC ACID Staphylococcus_aureus Added fusA_H457Y FUSIDIC ACID Staphylococcus_aureus Added fusA_L430S FUSIDIC ACID Staphylococcus_aureus Added fusA_L456F FUSIDIC ACID Staphylococcus_aureus Added fusA_L456K FUSIDIC ACID Staphylococcus_aureus Added fusA_L461F FUSIDIC ACID Staphylococcus_aureus Added fusA_L461K FUSIDIC ACID Staphylococcus_aureus Added fusA_L461S FUSIDIC ACID Staphylococcus_aureus Added fusA_M453I FUSIDIC ACID Staphylococcus_aureus Added fusA_M651I FUSIDIC ACID Staphylococcus_aureus Added fusA_P114H FUSIDIC ACID Staphylococcus_aureus Added fusA_P404L FUSIDIC ACID Staphylococcus_aureus Added fusA_P404Q FUSIDIC ACID Staphylococcus_aureus Added fusA_P406L FUSIDIC ACID Staphylococcus_aureus Added fusA_P478S FUSIDIC ACID Staphylococcus_aureus Added fusA_Q115L FUSIDIC ACID Staphylococcus_aureus Added fusA_R464C FUSIDIC ACID Staphylococcus_aureus Added fusA_R464H FUSIDIC ACID Staphylococcus_aureus Added fusA_R464L FUSIDIC ACID Staphylococcus_aureus Added fusA_R464S FUSIDIC ACID Staphylococcus_aureus Added fusA_R659C FUSIDIC ACID Staphylococcus_aureus Added fusA_R659H FUSIDIC ACID Staphylococcus_aureus Added fusA_R659L FUSIDIC ACID Staphylococcus_aureus Added fusA_R659S FUSIDIC ACID Staphylococcus_aureus Added fusA_S416F FUSIDIC ACID Staphylococcus_aureus Added fusA_T385N FUSIDIC ACID Staphylococcus_aureus Added fusA_T436I FUSIDIC ACID Staphylococcus_aureus Added fusA_T656K FUSIDIC ACID Staphylococcus_aureus Added fusA_V407F FUSIDIC ACID Staphylococcus_aureus Added fusA_V90A FUSIDIC ACID Staphylococcus_aureus Added fusA_V90I FUSIDIC ACID Staphylococcus_aureus Added fusA_Y654N FUSIDIC ACID Staphylococcus_aureus Added fusE_Q140L FUSIDIC ACID Staphylococcus_aureus Added glpT_F3I FOSFOMYCIN Staphylococcus_aureus Added glpT_G352D FOSFOMYCIN Staphylococcus_aureus Added glpT_L27F FOSFOMYCIN Staphylococcus_aureus Added glpT_V213I FOSFOMYCIN Staphylococcus_aureus Added glpT_W137R FOSFOMYCIN Staphylococcus_aureus Added gyrA_E88G QUINOLONE Staphylococcus_aureus Added gyrA_E88K QUINOLONE Staphylococcus_aureus Added gyrA_E88L QUINOLONE Staphylococcus_aureus Added gyrA_G106D QUINOLONE Staphylococcus_aureus Added gyrA_S84A QUINOLONE Staphylococcus_aureus Added gyrA_S84L QUINOLONE Staphylococcus_aureus Added gyrA_S85P QUINOLONE Staphylococcus_aureus Added gyrB_G84S AMINOCOUMARIN Staphylococcus_aureus Added gyrB_I101S AMINOCOUMARIN Staphylococcus_aureus Added gyrB_I55S AMINOCOUMARIN Staphylococcus_aureus Added gyrB_R143I AMINOCOUMARIN Staphylococcus_aureus Added gyrB_R143S AMINOCOUMARIN Staphylococcus_aureus Added gyrB_S127L AMINOCOUMARIN Staphylococcus_aureus Added gyrB_T172A AMINOCOUMARIN Staphylococcus_aureus Added ileS_V588F MUPIROCIN Staphylococcus_aureus Added ileS_V631F MUPIROCIN Staphylococcus_aureus Added mprF_G61V DAPTOMYCIN Staphylococcus_aureus Added mprF_I420N DAPTOMYCIN Staphylococcus_aureus Added mprF_L341S DAPTOMYCIN Staphylococcus_aureus Added mprF_L826F DAPTOMYCIN Staphylococcus_aureus Added mprF_M347R DAPTOMYCIN Staphylococcus_aureus Added mprF_P314L DAPTOMYCIN Staphylococcus_aureus Added mprF_S295L DAPTOMYCIN Staphylococcus_aureus Added mprF_S337L DAPTOMYCIN Staphylococcus_aureus Added mprF_T345A DAPTOMYCIN Staphylococcus_aureus Added mprF_T345I DAPTOMYCIN Staphylococcus_aureus Added mprF_T345K DAPTOMYCIN Staphylococcus_aureus Added mprF_T472K DAPTOMYCIN Staphylococcus_aureus Added mprF_V351E DAPTOMYCIN Staphylococcus_aureus Added murA_D278E FOSFOMYCIN Staphylococcus_aureus Added murA_E291D FOSFOMYCIN Staphylococcus_aureus Added murA_G257D FOSFOMYCIN Staphylococcus_aureus Added murA_Q362R FOSFOMYCIN Staphylococcus_aureus Added murA_T396N FOSFOMYCIN Staphylococcus_aureus Added murA_V65A FOSFOMYCIN Staphylococcus_aureus Added parC_A116E QUINOLONE Staphylococcus_aureus Added parC_E84G QUINOLONE Staphylococcus_aureus Added parC_E84K QUINOLONE Staphylococcus_aureus Added parC_E84L QUINOLONE Staphylococcus_aureus Added parC_E84V QUINOLONE Staphylococcus_aureus Added parC_S80F QUINOLONE Staphylococcus_aureus Added parC_S80Y QUINOLONE Staphylococcus_aureus Added parC_Y83N QUINOLONE Staphylococcus_aureus Added parE_D432H AMINOCOUMARIN Staphylococcus_aureus Added parE_D432N AMINOCOUMARIN Staphylococcus_aureus Added parE_G78S QUINOLONE Staphylococcus_aureus Added parE_N470S AMINOCOUMARIN Staphylococcus_aureus Added parE_P585S AMINOCOUMARIN Staphylococcus_aureus Added parE_R136G QUINOLONE Staphylococcus_aureus Added pbp2_S569A CEPHALOSPORIN Staphylococcus_aureus Added pbp4_E183A CEPHALOSPORIN Staphylococcus_aureus Added pbp4_F241R CEPHALOSPORIN Staphylococcus_aureus Added pgsA_A64V DAPTOMYCIN Staphylococcus_aureus Added pgsA_K66R DAPTOMYCIN Staphylococcus_aureus Added pgsA_S177F DAPTOMYCIN Staphylococcus_aureus Added pgsA_V59N DAPTOMYCIN Staphylococcus_aureus Added rpoB_A1085V DAPTOMYCIN Staphylococcus_aureus Added rpoB_A473T RIFAMPIN Staphylococcus_aureus Added rpoB_A477D RIFAMPIN Staphylococcus_aureus Added rpoB_A477T RIFAMPIN Staphylococcus_aureus Added rpoB_A477V RIFAMPIN Staphylococcus_aureus Added rpoB_A621E DAPTOMYCIN Staphylococcus_aureus Added rpoB_D471G RIFAMPIN Staphylococcus_aureus Added rpoB_D471Y RIFAMPIN Staphylococcus_aureus Added rpoB_D550G RIFAMPIN Staphylococcus_aureus Added rpoB_H481D RIFAMPIN Staphylococcus_aureus Added rpoB_H481N RIFAMPIN Staphylococcus_aureus Added rpoB_H481Y RIFAMPIN Staphylococcus_aureus Added rpoB_I527F RIFAMPIN Staphylococcus_aureus Added rpoB_I527L RIFAMPIN Staphylococcus_aureus Added rpoB_I527M RIFAMPIN Staphylococcus_aureus Added rpoB_I953S DAPTOMYCIN Staphylococcus_aureus Added rpoB_L466S RIFAMPIN Staphylococcus_aureus Added rpoB_M470T RIFAMPIN Staphylococcus_aureus Added rpoB_N474KG RIFAMPIN Staphylococcus_aureus Added rpoB_N474K RIFAMPIN Staphylococcus_aureus Added rpoB_N474NH RIFAMPIN Staphylococcus_aureus Added rpoB_Q465K RIFAMPIN Staphylococcus_aureus Added rpoB_Q465R RIFAMPIN Staphylococcus_aureus Added rpoB_Q468K RIFAMPIN Staphylococcus_aureus Added rpoB_R484H RIFAMPIN Staphylococcus_aureus Added rpoB_S463P RIFAMPIN Staphylococcus_aureus Added rpoB_S464P RIFAMPIN Staphylococcus_aureus Added rpoB_S486L RIFAMPIN Staphylococcus_aureus Added rpoB_S529L RIFAMPIN Staphylococcus_aureus Added rpoC_F632S DAPTOMYCIN Staphylococcus_aureus Added rpoC_Q961K DAPTOMYCIN Staphylococcus_aureus Added uhpT_G112E FOSFOMYCIN Staphylococcus_aureus Added uhpT_G358V FOSFOMYCIN Staphylococcus_aureus Added uhpT_W228STOP FOSFOMYCIN Staphylococcus_aureus Added uhpT_W425R FOSFOMYCIN Staphylococcus_aureus Added uhpT_Y314STOP FOSFOMYCIN Staphylococcus_aureus Added walK_L10F DAPTOMYCIN Staphylococcus_aureus Added walK_R263C DAPTOMYCIN Staphylococcus_aureus Added walK_S221P DAPTOMYCIN Staphylococcus_aureus Changes: Changed faeG AAA24032.1 product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG Changed faeG AAA24035.1 product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG Changed faeG AAA24390.1 product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG Changed arsB AAA25637.1 blacklisted_taxa: Staphylococcus -> Staphylococcus_pseudintermedius Changed arsB AAA27588.1 blacklisted_taxa: Staphylococcus -> Staphylococcus_pseudintermedius Changed faeG AAC34727.1 product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG Changed faeG ACB72721.1 product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG Changed faeG AFH14350.1 product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG Changed faeG CAE82650.1 product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG Changed faeG CAE82653.1 product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG Changed faeG CAE82670.1 product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG Changed iucA EGI25746.1 genbank_cds_start: -> 406312 genbank_cds_stop: -> 408042 genbank_nucleotide_accession: -> GL884188.1 Changed aac(3)-IIe WP_000557452.1 gene_family: aac(3)-IIa -> aac(3)-IIe product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe Changed aac(3)-IId WP_000557454.1 allele: aac(3)-IId -> gene_family: aac(3)-II -> aac(3)-IId Changed aac(3)-IVa WP_001199192.1 gene_family: aac(3)-IV -> aac(3)-IVa product_name: aminoglycoside N-acetyltransferase AAC(3)-IV -> aminoglycoside N-acetyltransferase AAC(3)-IVa Changed aac(3)-IIe WP_002063884.1 gene_family: aac(3)-IIa -> aac(3)-IIe product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe Changed aac(3)-Ia WP_002089484.1 gene_family: aac(3)-I -> aac(3)-Ia product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia Changed aac(3)-Id WP_003155734.1 gene_family: aac(3)-I -> aac(3)-Id product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Id Changed aac(3)-Ib WP_010792467.1 allele: aac(3)-Ib -> gene_family: aac(3)-I -> aac(3)-Ib Changed aac(3)-Ig WP_011468318.1 allele: aac(3)-Ig -> gene_family: aac(3)-I -> aac(3)-Ig Changed aac(3)-Ii WP_011540937.1 allele: aac(3)-Ii -> gene_family: aac(3)-I -> aac(3)-Ii Changed aac(3)-Ih WP_011749610.1 allele: aac(3)-Ih -> gene_family: aac(3)-I -> aac(3)-Ih Changed aac(6')-Ib WP_013250882.1 subclass: AMINOGLYCOSIDE -> GENTAMICIN Changed aac(6')-Ib' WP_014454105.1 subclass: AMINOGLYCOSIDE -> GENTAMICIN Changed aac(3)-IIe WP_015060297.1 gene_family: aac(3)-IIa -> aac(3)-IIe product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe Changed mphM WP_016078774.1 gene_family: mph(B) -> mphM product_name: Mph(B) family macrolide 2'-phosphotransferase -> macrolide 2'-phosphotransferase MphM Changed aac(3)-Ia WP_022542381.1 gene_family: aac(3)-I -> aac(3)-Ia product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia Changed aac(6')-Ib WP_022631510.1 subclass: AMINOGLYCOSIDE -> GENTAMICIN Changed aac(6')-Ib11 WP_032490438.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN Changed aac(3)-Ia WP_032491356.1 gene_family: aac(3)-I -> aac(3)-Ia product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia Changed aac(3)-Ia WP_032492247.1 allele: aac(3)-Ia -> curated_refseq_start: No -> Yes gene_family: aac(3)-I -> aac(3)-Ia Changed aac(3)-IIb WP_033147097.1 allele: aac(3)-IIb -> gene_family: aac(3)-II -> aac(3)-IIb Changed aac(3)-Ic WP_034006142.1 allele: aac(3)-Ic -> gene_family: aac(3)-I -> aac(3)-Ic Changed aac(3)-Id WP_038404949.1 allele: aac(3)-Id -> gene_family: aac(3)-I -> aac(3)-Id Changed blaMCA WP_057991970.1 gene_family: ampC -> blaMCA Changed WP_063838853.1 subclass: AMINOGLYCOSIDE -> GENTAMICIN Changed WP_063839875.1 subclass: AMINOGLYCOSIDE -> STREPTOMYCIN/SPECTINOMYCIN Changed aac(3)-Ia WP_063840257.1 gene_family: aac(3)-I -> aac(3)-Ia product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia Changed aac(3)-Ia WP_063840258.1 gene_family: aac(3)-I -> aac(3)-Ia product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia Changed aac(3)-Ia WP_063840259.1 gene_family: aac(3)-I -> aac(3)-Ia product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia Changed aac(3)-IIc WP_063840266.1 allele: aac(3)-IIc -> gene_family: aac(3)-II -> aac(3)-IIc Changed aac(6')-Ib WP_063840281.1 subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN Changed aac(6')-Ib WP_063840282.1 subclass: AMINOGLYCOSIDE -> KANAMYCIN Changed aac(6')-Ib WP_063840283.1 subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN Changed aac(6')-Ib WP_063840319.1 subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN Changed aac(6')-Ib-cr6 WP_063840320.1 subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE Changed aac(6')-Ib-cr5 WP_063840321.1 subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE Changed aac(3)-If WP_063856942.1 allele: aac(3)-If -> gene_family: aac(3)-I -> aac(3)-If Changed blaADC-68 WP_063857815.1 subclass: CEPHALOSPORIN -> CARBAPENEM Changed aac(6')-Ib-cr4 WP_065187000.1 subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE Changed aac(6')-Ib WP_065187201.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN Changed aac(6')-Ib11 WP_069985732.1 subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN Changed WP_071593228.1 subclass: AMINOGLYCOSIDE -> GENTAMICIN Changed aac(6')-Ib-cr7 WP_071766399.1 subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE Changed aac(6')-Ib-cr3 WP_071766621.1 subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE Changed aac(6')-Ib-cr WP_071846215.1 subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE Changed aac(6')-Ib WP_071846254.1 subclass: GENTAMICIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN Changed aac(6')-Ib WP_071846329.1 gene_family: aac(6')-Ib' -> aac(6')-Ib product_name: aminoglycoside N-acetyltransferase AAC(6')-Ib' -> AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase Changed aac(3)-If WP_071846359.1 gene_family: aac(3)-I -> aac(3)-If product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-If Changed aac(6')-Ib WP_071846382.1 subclass: AMINOGLYCOSIDE -> GENTAMICIN - AMR HMM library Changes: Total: Added 6 Total: Prev. Release 620 Total: Removed 1 Total: This Release 625 HMM Removed: NF000242.1 macrolide_MphB-NCBI HMM Added: NF000242.2 macrolide_MphB-NCBI HMM Added: NF033862.2 polymyxin_MCR10-NCBI HMM Added: NF038046.1 blaCVI-NCBI HMM Added: NF038056.1 macrolide_MphM-NCBI HMM Added: NF038057.1 macrolide_MphL-NCBI HMM Added: NF038069.1 blaIDC-NCBI - Protein family changes: Total: Added 32 Total: Prev. Release 1536 Total: Removed 1 Total: This Release 1567 Family Removed: - aac(3)-IV Family Added: - aac(3)-IIb Family Added: - aac(3)-IIc Family Added: - aac(3)-IId Family Added: - aac(3)-Ia Family Added: - aac(3)-Ib Family Added: - aac(3)-Ic Family Added: - aac(3)-Id Family Added: - aac(3)-If Family Added: - aac(3)-Ig Family Added: - aac(3)-Ih Family Added: - aac(3)-Ii Family Added: - aac(6')-Ib-AGKT Family Added: - aac(6')-Ib-AKT Family Added: - aac(6')-Ib-D181Y Family Added: - aac(6')-Ib-G Family Added: - aac(6')-Ib-K Family Added: - aac(6')-Ib-KT Family Added: - aac(6')-Ib-W104R Family Added: - aac(6')-Ib-generic Family Added: - abaF Family Added: - almG Family Added: - ant(3'')-Ij Family Added: NF038046.1 blaCVI Family Added: NF038069.1 blaIDC Family Added: - blaPNGM Family Added: - blaRSA2 Family Added: - blaRSC1 Family Added: - blaRSD1 Family Added: - blaRSD2 Family Added: - catB8j Family Added: - papF Family Added: - tet(55) Family Changed: - mcr-10 updated to NF033862.2 mcr-10 Family Changed: NF000242.1 mph(B) updated to NF000242.2 mph(B) Family Changed: - mphL updated to NF038057.1 mphL Family Changed: - mphM updated to NF038056.1 mphM ---------------------------------------------------------------------- Changes included in 2020-01-22.1 ---------------------------------------------------------------------- This release includes a renaming of the gene symbols for stx to conform to the Scheutz et al., 2012 (pmid: 22760050), new AMR alleles, and five new virulence factor genes. - Reference Gene Catalog changes (proteins and point mutations): Total in prev: 6622 Total in release: 6672 Removed: 0 Added: 50 Changed: 118 Added espB AAC38396.1 Added fdeC ABE05822.1 Added espX1 ADD54679.1 Added iucA EGI25746.1 Added fosA7.5 WP_000941933.1 Added fosA7.2 WP_000941935.1 Added blaADC-226 WP_001211224.1 Added blaB-19 WP_019051344.1 Added blaB-17 WP_021348010.1 Added fosA7.4 WP_023216493.1 Added fosA7.3 WP_023231494.1 Added blaB-21 WP_029728367.1 Added blaADC-233 WP_031950434.1 Added blaADC-222 WP_031960999.1 Added fosA7.7 WP_058653118.1 Added fosA7.6 WP_061377147.1 Added blaADC-232 WP_064907116.1 Added blaADC-224 WP_064907831.1 Added blaADC-223 WP_064987478.1 Added blaB-26 WP_065083535.1 Added blaB-33 WP_065161001.1 Added blaB-22 WP_068801164.1 Added blaB-23 WP_069214019.1 Added blaB-31 WP_078675249.1 Added blaB-18 WP_078691467.1 Added blaB-25 WP_078702010.1 Added blaB-24 WP_078704370.1 Added blaB-32 WP_078723747.1 Added blaB-35 WP_078793100.1 Added blaB-38 WP_078795346.1 Added fosA7.8 WP_079820715.1 Added blaGOB-19 WP_086979105.1 Added blaB-16 WP_086980232.1 Added blaB-20 WP_101360538.1 Added cfr(D) WP_105459893.1 Added blaCTX-M-154 WP_110093562.1 Added blaKPC-52 WP_158208806.1 Added blaKPC-51 WP_158208923.1 Added blaADC-225 WP_160164833.1 Added blaADC-227 WP_160164834.1 Added blaADC-228 WP_160164835.1 Added blaADC-229 WP_160164836.1 Added blaADC-230 WP_160164837.1 Added blaADC-231 WP_160164838.1 Added blaKPC-54 WP_160164839.1 Added blaVEB-25 WP_160164840.1 Added mcr-1.23 WP_160164897.1 Added mcr-1.24 WP_160164898.1 Added mcr-1.25 WP_160164899.1 Added iroE YP_002527501.1 Changes: stxA2b AAA16360.1 gene_family stx2Ab -> stxA2b stxB2b AAA16361.1 gene_family stx2Bb -> stxB2b stxA2c AAA16362.1 gene_family stx2Ac -> stxA2c stxA2e AAA19189.1 gene_family stx2Ae -> stxA2e stxB2e AAA19190.1 gene_family stx2Be -> stxB2e stxA2f AAA24632.1 gene_family stx2Af -> stxA2f stxB2f AAA24633.1 gene_family stx2Bf -> stxB2f stxA1a AAA71893.1 gene_family stx1Aa -> stxA1a stxB1a AAA71894.1 gene_family stx1Ba -> stxB1a stxA1a AAA98099.1 gene_family stx1Aa -> stxA1a stxA2e AAC45964.1 gene_family stx2Ae -> stxA2e stxB2e AAC45965.1 gene_family stx2Be -> stxB2e stxA2b AAD12174.1 gene_family stx2Ab -> stxA2b stxA2c AAG01033.1 gene_family stx2Ac -> stxA2c stxA2d AAK66972.1 gene_family stx2Ad -> stxA2d stxA2d AAM22256.1 gene_family stx2Ad -> stxA2d stxB2d AAM22257.1 gene_family stx2Bd -> stxB2d stxA2a AAM70045.1 gene_family stx2Aa -> stxA2a stxA2d AAM88302.1 gene_family stx2Ad -> stxA2d stxB2a AAM90978.1 gene_family stx2Ba -> stxB2a stxA2d AAN77057.1 gene_family stx2Ad -> stxA2d stxA2d AAN77061.1 gene_family stx2Ad -> stxA2d stxA2d AAN77063.1 gene_family stx2Ad -> stxA2d stxA1d AAO19475.1 gene_family stx1Ad -> stxA1d stxB1d AAO19476.1 gene_family stx1Bd -> stxB1d stxA2g AAP37403.1 gene_family stx2Ag -> stxA2g stxA2e AAQ17546.1 gene_family stx2Ae -> stxA2e stxA2c AAS07580.1 gene_family stx2Ac -> stxA2c stxB2c AAS07581.1 gene_family stx2Bc -> stxB2c stxA2c AAS07582.1 gene_family stx2Ac -> stxA2c stxA2d AAS07586.1 gene_family stx2Ad -> stxA2d stxA2d AAS07588.1 gene_family stx2Ad -> stxA2d stxB2d AAS07589.1 gene_family stx2Bd -> stxB2d stxA2c AAS07590.1 gene_family stx2Ac -> stxA2c stxA2c AAS07596.1 gene_family stx2Ac -> stxA2c stxA2a AAS07600.1 gene_family stx2Aa -> stxA2a stxA2a AAS07606.1 gene_family stx2Aa -> stxA2a stxA2c AAT65972.1 gene_family stx2Ac -> stxA2c stxA2c AAT66000.1 gene_family stx2Ac -> stxA2c stxA2a AAT66010.1 gene_family stx2Aa -> stxA2a stxB2a AAT66011.1 gene_family stx2Ba -> stxB2a stxA2c AAT66012.1 gene_family stx2Ac -> stxA2c stxA2c AAU88208.1 gene_family stx2Ac -> stxA2c stxA2d AAY63864.1 gene_family stx2Ad -> stxA2d stxB2d AAY63865.1 gene_family stx2Bd -> stxB2d stxA2c ABB36584.1 gene_family stx2Ac -> stxA2c stxA2d ABB36586.1 gene_family stx2Ad -> stxA2d stxA2a ABC67318.2 gene_family stx2Aa -> stxA2a stxB2a ABR09925.1 gene_family stx2Ba -> stxB2a stxA2c ABR09934.1 gene_family stx2Ac -> stxA2c stxB2c ABR09935.1 gene_family stx2Bc -> stxB2c stxA2d ABR09936.1 gene_family stx2Ad -> stxA2d stxB2d ABR09937.1 gene_family stx2Bd -> stxB2d stxB2a ABR09945.1 gene_family stx2Ba -> stxB2a stxB2a ABR09961.1 gene_family stx2Ba -> stxB2a stxB2a ABR09963.1 gene_family stx2Ba -> stxB2a stxA2b ABR10024.1 gene_family stx2Ab -> stxA2b stxA2c ABU55302.1 gene_family stx2Ac -> stxA2c stxA2a ACU32684.1 gene_family stx2Aa -> stxA2a stxA2b BAA77749.1 gene_family stx2Ab -> stxA2b stxB2b BAA77750.1 gene_family stx2Bb -> stxB2b stxA2b BAA77751.1 gene_family stx2Ab -> stxA2b stxA2c BAB68369.1 gene_family stx2Ac -> stxA2c stxB2c BAB68370.1 gene_family stx2Bc -> stxB2c stxA2b BAB82994.1 gene_family stx2Ab -> stxA2b stxA2b BAB82996.1 gene_family stx2Ab -> stxA2b stxA2b BAB82998.1 gene_family stx2Ab -> stxA2b stxA2b BAB83000.1 gene_family stx2Ab -> stxA2b stxA2g BAB83002.1 gene_family stx2Ag -> stxA2g stxB2g BAB83003.1 gene_family stx2Bg -> stxB2g stxB2b BAB83005.1 gene_family stx2Bb -> stxB2b stxB2b BAB83007.1 gene_family stx2Bb -> stxB2b stxA2g BAB83020.1 gene_family stx2Ag -> stxA2g stxA1c BAB83022.1 gene_family stx1Ac -> stxA1c stxB1c BAB83023.1 gene_family stx1Bc -> stxB1c stxA2b BAB83024.1 gene_family stx2Ab -> stxA2b stxA1c BAC10987.1 gene_family stx1Ac -> stxA1c stxB1c BAC10988.1 gene_family stx1Bc -> stxB1c stxB1c BAC10992.1 gene_family stx1Bc -> stxB1c stxA1a BAC78639.1 gene_family stx1Aa -> stxA1a stxB1a BAC78640.1 gene_family stx1Ba -> stxB1a stxA2f BAH86759.1 gene_family stx2Af -> stxA2f stxB2f BAH86760.1 gene_family stx2Bf -> stxB2f stxA2c CAA30714.1 gene_family stx2Ac -> stxA2c stxB2a CAA30715.1 gene_family stx2Ba -> stxB2a stxA2d CAA43585.1 gene_family stx2Ad -> stxA2d stxA2b CAA46767.1 gene_family stx2Ab -> stxA2b stxB2b CAA46768.1 gene_family stx2Bb -> stxB2b stxA2e CAA57171.1 gene_family stx2Ae -> stxA2e stxA2e CAA57173.1 gene_family stx2Ae -> stxA2e stxA2e CAA57175.1 gene_family stx2Ae -> stxA2e stxA2e CAA57177.1 gene_family stx2Ae -> stxA2e stxA1a CAA85366.1 gene_family stx1Aa -> stxA1a stxA1a CAA85368.1 gene_family stx1Aa -> stxA1a stxA1c CAA85370.1 gene_family stx1Ac -> stxA1c stxB1c CAA85371.1 gene_family stx1Bc -> stxB1c stxA2a CAA85780.1 gene_family stx2Aa -> stxA2a stxA2a CAA90630.1 gene_family stx2Aa -> stxA2a stxA2f CAB64953.1 gene_family stx2Af -> stxA2f stxA2e CAB77169.2 gene_family stx2Ae -> stxA2e stxB2a CAB94149.1 gene_family stx2Ba -> stxB2a stxA2b CAC48396.1 gene_family stx2Ab -> stxA2b stxA2e CAC48398.1 gene_family stx2Ae -> stxA2e stxA2g CAI91198.1 gene_family stx2Ag -> stxA2g stxA1a CAJ76690.1 gene_family stx1Aa -> stxA1a stxA1a CAJ76692.1 gene_family stx1Aa -> stxA1a stxA2e CAP17609.1 gene_family stx2Ae -> stxA2e stxB2e CAP17610.1 gene_family stx2Be -> stxB2e stxA2c CAQ68302.1 gene_family stx2Ac -> stxA2c stxA2e CAX45702.1 gene_family stx2Ae -> stxA2e stxA2d CAX45706.1 gene_family stx2Ad -> stxA2d stxA2e CAX45714.1 gene_family stx2Ae -> stxA2e stxA2e CAX45718.1 gene_family stx2Ae -> stxA2e stxB2d CAX45737.1 gene_family stx2Bd -> stxB2d stxB2a CAX45739.1 gene_family stx2Ba -> stxB2a stxA2c CAX45746.1 gene_family stx2Ac -> stxA2c stxA2e CAX51714.1 gene_family stx2Ae -> stxA2e blaFOX-4 WP_032489727.1 product_name cephalosporin-hydrolyzing class C beta-lactamase FOX-4 -> inhbitor-resistant cephalosporin-hydrolyzing class C beta-lactamase FOX-4 - AMR HMM library Changes: Total: Added 1 Total: Prev. Release 620 Total: Removed 0 Total: This Release 621 HMM Added: NF033423.1 linco_LnuA-NCBI HMM Modified: NF033639.1 linco_LnuA-NCBI updated to NF033639.1 inverse_SinH-NCBI - Protein family changes: Total: Added 6 Total: Prev. Release 1530 Total: Removed 0 Total: This Release 1536 Family Renamed: NF033658.1 stx1A -> stxA1 Family Renamed: - stx1Aa -> stxA1a Family Renamed: - stx1Ac -> stxA1c Family Renamed: - stx1Ad -> stxA1d Family Renamed: NF033659.0 stx1B -> stxB1 Family Renamed: - stx1Ba -> stxB1a Family Renamed: - stx1Bc -> stxB1c Family Renamed: - stx1Bd -> stxB1d Family Renamed: NF033661.1 stx2A -> stxA2 Family Renamed: - stx2Aa -> stxA2a Family Renamed: - stx2Ab -> stxA2b Family Renamed: - stx2Ac -> stxA2c Family Renamed: - stx2Ad -> stxA2d Family Renamed: - stx2Ae -> stxA2e Family Renamed: - stx2Af -> stxA2f Family Renamed: - stx2Ag -> stxA2g Family Renamed: NF033660.0 stx2B -> stxB2 Family Renamed: - stx2Ba -> stxB2a Family Renamed: - stx2Bb -> stxB2b Family Renamed: - stx2Bc -> stxB2c Family Renamed: - stx2Bd -> stxB2d Family Renamed: - stx2Be -> stxB2e Family Renamed: - stx2Bf -> stxB2f Family Renamed: - stx2Bg -> stxB2g Family Added: - cfr(D) Family Added: - espX1 Family Added: - fdeC Family Added: - iroE Family Added: - iucA Family Added: NF033423.1 sinH --------------------------------------------------------------------- Changes included in 2020-01-06.1 --------------------------------------------------------------------- This update includes backward incompatible changes to the AMRFinderPlus database format. It is compatible with AMRFinderPlus version 3.6. To use this database version please update to AMRFinderPlus version 3.6. See https://github.com/ncbi/amr/wiki/Upgrading for how to upgrade and https://github.com/evolarjun/amr/wiki/AMRFinderPlus-database for information on the new database format. Some highlights: - Database format has changed to allow AMRFinderPlus to detect promoter mutations and small indels - Many new point mutations, including Escherichia ampC promoter mutations, Klebsiella, and Enterococcus mutations - Small improvements to many product names - Improvements in class and subclass phenotype designations - Modifications and additions of a few HMMs - The usual addition of new alleles submitted to NCBI and others gleaned from the literature - Protein and point mutations: Total in prev: 6443 Total in release: 6622 Removed: 0 Added: 184 Protein Added: ABV01310.1 ltcA heat-labile_enterotoxin_LT_subunit_A Protein Added: ADE89421.1 sslE lipoprotein_metalloprotease_SslE Protein Added: ASK37426.1 aar AggR-activated_transcriptional_regulator_Aar Protein Added: BAB41547.1 mepA multidrug_efflux_MATE_transporter_MepA Protein Added: WP_000378442.1 emrR multidrug_efflux_transporter_EmrAB_transcriptional_repressor_EmrR Protein Added: WP_001132507.1 acrB multidrug_efflux_RND_transporter_permease_subunit_AcrB Protein Added: WP_002289153.1 liaR response_regulator_transcription_factor_LiaR Protein Added: WP_002289154.1 liaS sensor_histidine_kinase_LiaS Protein Added: WP_002289473.1 cls cardiolipin_synthase_Cls Protein Added: WP_002295408.1 liaF three-component_signaling_pathway_regulator_LiaF Protein Added: WP_002355137.1 liaR response_regulator_transcription_factor_LiaR Protein Added: WP_002356022.1 yybT cyclic_dinucleotide_phosphodiesterase_YybT Protein Added: WP_002365182.1 liaS sensor_histidine_kinase_LiaS Protein Added: WP_002371880.1 parC DNA_topoisomerase_IV_subunit_A_ParC Protein Added: WP_002381168.1 liaF three-component_signaling_pathway_regulator_LiaF Protein Added: WP_002389492.1 gshF bifunctional_glutamate--cysteine_ligase/glutathione_synthetase_GshF Protein Added: WP_002413481.1 cls cardiolipin_synthase_Cls Protein Added: WP_002895659.1 pmrA two-component_system_response_regulator_PmrA Protein Added: WP_002911375.1:47:mgrB_W47R mgrB PhoP/PhoQ_regulator_MgrB Protein Added: WP_004147969.1 phoQ two-component_system_sensor_histidine_kinase_PhoQ Protein Added: WP_004150807.1 phoP two-component_system_response_regulator_PhoP Protein Added: WP_004179093.1 pmrB two-component_system_sensor_histidine_kinase_PmrB Protein Added: WP_004184324.1 crrB HAMP_domain-containing_histidine_kinase_CrrB Protein Added: WP_014906821.1 arnC undecaprenyl-phosphate_4-deoxy-4-formamido-L-arabinose_transferase_ArnC Protein Added: WP_033554192.1 parE DNA_topoisomerase_IV_subunit_B_ParE Protein Added: WP_033785346.1 gyrA DNA_gyrase_subunit_A_GyrA Protein Added: WP_048324114.1 blaOKP-B-45 class_A_broad-spectrum_beta-lactamase_OKP-B-45 Protein Added: WP_049003700.1 blaOKP-B-41 class_A_broad-spectrum_beta-lactamase_OKP-B-41 Protein Added: WP_057012521.1 blaPFM-2 subclass_B2_metallo-beta-lactamase_PFM-2 Protein Added: WP_060573544.1 blaACT-77 cephalosporin-hydrolyzing_class_C_beta-lactamase_ACT-77 Protein Added: WP_060655783.1 blaOKP-B-36 class_A_broad-spectrum_beta-lactamase_OKP-B-36 Protein Added: WP_064183695.1 blaOKP-B-16 class_A_broad-spectrum_beta-lactamase_OKP-B-16 Protein Added: WP_080897395.1 blaOKP-D-1 class_A_broad-spectrum_beta-lactamase_OKP-D-1 Protein Added: WP_086259262.1 acrB multidrug_efflux_RND_transporter_permease_subunit_AcrB Protein Added: WP_087771722.1 blaOKP-B-34 class_A_broad-spectrum_beta-lactamase_OKP-B-34 Protein Added: WP_087833272.1 blaOKP-B-21 class_A_broad-spectrum_beta-lactamase_OKP-B-21 Protein Added: WP_100886243.1 blaOXA-895 OXA-229_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-895 Protein Added: WP_101982161.1 parC DNA_topoisomerase_IV_subunit_A_ParC Protein Added: WP_114508147.1 blaOKP-B-40 class_A_broad-spectrum_beta-lactamase_OKP-B-40 Protein Added: WP_115256011.1 parC DNA_topoisomerase_IV_subunit_A_ParC Protein Added: WP_117036963.1 gyrA DNA_gyrase_subunit_A_GyrA Protein Added: WP_122543028.1 blaOKP-B-22 class_A_broad-spectrum_beta-lactamase_OKP-B-22 Protein Added: WP_125353308.1 qnrB96 quinolone_resistance_pentapeptide_repeat_protein_QnrB96 Protein Added: WP_130202201.1 blaVIM-69 subclass_B1_metallo-beta-lactamase_VIM-69 Protein Added: WP_131419583.1 blaTEM-238 class_A_beta-lactamase_TEM-238 Protein Added: WP_136034107.1 blaOKP-C-1 class_A_broad-spectrum_beta-lactamase_OKP-C-1 Protein Added: WP_137277832.1 gyrA DNA_gyrase_subunit_A_GyrA Protein Added: WP_156404644.1 blaADC-221 class_C_beta-lactamase_ADC-221 Protein Added: WP_156404645.1 blaCMH-6 class_C_beta-lactamase_CMH-6 Protein Added: WP_156404646.1 blaCMY-168 class_C_beta-lactamase_CMY-168 Protein Added: WP_156404647.1 blaCMY-169 class_C_beta-lactamase_CMY-169 Protein Added: WP_156404648.1 blaCMY-170 class_C_beta-lactamase_CMY-170 Protein Added: WP_156404649.1 blaCTX-M-143 class_A_extended-spectrum_beta-lactamase_CTX-M-143 Protein Added: WP_156404650.1 blaCTX-M-230 class_A_extended-spectrum_beta-lactamase_CTX-M-230 Protein Added: WP_156404651.1 blaCTX-M-231 class_A_extended-spectrum_beta-lactamase_CTX-M-231 Protein Added: WP_156404652.1 blaCTX-M-232 class_A_extended-spectrum_beta-lactamase_CTX-M-232 Protein Added: WP_156404653.1 blaCTX-M-233 class_A_extended-spectrum_beta-lactamase_CTX-M-233 Protein Added: WP_156404654.1 blaMOX-14 CMY-1/MOX_family_class_C_beta-lactamase_MOX-14 Protein Added: WP_156404655.1 blaNDM-26 subclass_B1_metallo-beta-lactamase_NDM-26 Protein Added: WP_156404656.1 blaNDM-29 subclass_B1_metallo-beta-lactamase_NDM-29 Protein Added: WP_156404657.1 blaOKP-B-24 class_A_broad-spectrum_beta-lactamase_OKP-B-24 Protein Added: WP_156404658.1 blaOXA-896 class_D_beta-lactamase_OXA-896 Protein Added: WP_156404659.1 blaPER-14 class_A_extended-spectrum_beta-lactamase_PER-14 Protein Added: WP_156404660.1 blaPFM-3 subclass_B2_metallo-beta-lactamase_PFM-3 Protein Added: WP_156404661.1 blaSHV-115 class_A_extended-spectrum_beta-lactamase_SHV-115 Protein Added: WP_156404662.1 blaVEB-23 class_A_extended-spectrum_beta-lactamase_VEB-23 Protein Added: WP_156404663.1 blaVEB-24 class_A_extended-spectrum_beta-lactamase_VEB-24 Changes to existing protein and point mutation records: Changed mepA accesssion: Q7A7N0.1 -> BAB41547.1 Changed ltcA accession: ABV01314.1 -> ABV01310.1 Changed aar accession: AVL28824.1 -> ASK37426.1 Changed reference sequence for Escherichia parE point mutations: WP_000195296.1 -> WP_033554192.1 Changed reference sequence for Escherichia acrB point mutations: WP_097509477.1 -> WP_086259262.1 16S_A1055G NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_A1408G NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + subclass AMINOGLYCOSIDE -> GENTAMICIN C/NEOMYCIN/PAROMOMYCIN 16S_A1499G NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_A1519C NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_A1519G NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_A1519T NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_A523C NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_A794G NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_A794T NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_A964G NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_C1054T NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_C1065T NC_003197.2 genbank_nucleotide_accession -> AE006468.2 genbank_strand_orientation -> + 16S_C1066T NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_C1192T NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_C1192T NC_003197.2 genbank_nucleotide_accession -> AE006468.2 genbank_strand_orientation -> + 16S_C528T NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_G1053A NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_G1058C NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_G1064A NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + subclass KANAMYCIN -> SPECTINOMYCIN 16S_G1064C NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_G1064T NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_G1068A NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_G527T NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_G926A NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_G926C NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_G926T NC_000913.3 genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + 16S_T1406A NC_000913.3 class AMINOGLYCOSIDE -> AMINGLYCOSIDE genbank_nucleotide_accession -> U00096.3 genbank_strand_orientation -> + subclass G418 -> G418/TOBRAMYCIN 23S_A2058G NC_004431.1 genbank_nucleotide_accession -> AE014075.1 genbank_strand_orientation -> + subclass MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TELITHROMYCIN 23S_A2058T NC_004431.1 genbank_nucleotide_accession -> AE014075.1 genbank_strand_orientation -> + subclass MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TELITHROMYCIN 23S_A2074C NC_002163.1 genbank_nucleotide_accession -> AL111168.1 genbank_strand_orientation -> + 23S_A2074G NC_002163.1 genbank_nucleotide_accession -> AL111168.1 genbank_strand_orientation -> + 23S_A2074T NC_002163.1 genbank_nucleotide_accession -> AL111168.1 genbank_strand_orientation -> + 23S_A2075G NC_002163.1 genbank_nucleotide_accession -> AL111168.1 genbank_strand_orientation -> + 23S_C2611T NC_004431.1 genbank_nucleotide_accession -> AE014075.1 genbank_strand_orientation -> + subclass MACROLIDE -> ERYTHROMYCIN/TELITHROMYCIN 23S_C2627A NC_002163.1 genbank_nucleotide_accession -> AL111168.1 genbank_strand_orientation -> + 23S_G2032A NC_004431.1 class MACROLIDE/OXAZOLIDINONE -> LINCOSAMIDE/OXAZOLIDINONE genbank_nucleotide_accession -> AE014075.1 genbank_strand_orientation -> + subclass MACROLIDE/OXAZOLIDINONE -> CLINDAMYCIN/LINEZOLID 23S_G2032C NC_004431.1 genbank_nucleotide_accession -> AE014075.1 genbank_strand_orientation -> + subclass OXAZOLIDINONE -> LINEZOLID 23S_G2032T NC_004431.1 genbank_nucleotide_accession -> AE014075.1 genbank_strand_orientation -> + subclass MACROLIDE/OXAZOLIDINONE -> CLARITHROMYCIN/LINEZOLID 23S_G2057A NC_004431.1 class MACROLIDE/PHENICOL -> MULTIDRUG genbank_nucleotide_accession -> AE014075.1 genbank_strand_orientation -> + subclass MACROLIDE/CHLORAMPHENICOL -> CHLORAMPHENICOL/ERYTHROMYCIN/TELITHROMYCIN 23S_G2447T NC_004431.1 genbank_nucleotide_accession -> AE014075.1 genbank_strand_orientation -> + subclass OXAZOLIDINONE -> LINEZOLID 23S_T754A NC_004431.1 genbank_nucleotide_accession -> AE014075.1 genbank_strand_orientation -> + subclass MACROLIDE -> ERYTHROMYCIN/TELITHROMYCIN 50S_L22_A103C WP_002851214.1 genbank_protein_accession -> CAL35796.1 50S_L22_A103V WP_002779996.1 genbank_protein_accession -> AJW59082.1 50S_L22_A103V WP_002851214.1 genbank_protein_accession -> CAL35796.1 50S_L22_A84D WP_002779996.1 genbank_protein_accession -> AJW59082.1 50S_L22_A84D WP_002851214.1 genbank_protein_accession -> CAL35796.1 50S_L22_A88E WP_002779996.1 genbank_protein_accession -> AJW59082.1 50S_L22_A88E WP_002851214.1 genbank_protein_accession -> CAL35796.1 50S_L22_G86E WP_002779996.1 genbank_protein_accession -> AJW59082.1 50S_L22_G86E WP_002851214.1 genbank_protein_accession -> CAL35796.1 50S_L22_G86V WP_002779996.1 genbank_protein_accession -> AJW59082.1 50S_L22_G86V WP_002851214.1 genbank_protein_accession -> CAL35796.1 astA AAA20885.1 class VIRULENCE -> subclass astA -> arsB AAA21095.1 blacklisted_taxa Escherichia -> arsC AAA21096.1 blacklisted_taxa Escherichia -> arsB AAA25637.1 blacklisted_taxa Staphylococcus -> arsB AAA27588.1 blacklisted_taxa Staphylococcus -> arsC AAB09628.1 blacklisted_taxa Escherichia -> ehxA AAC24352.1 product_name enterohemolysin -> enterohemolysin EhxA astA AAD43578.1 class VIRULENCE -> subclass astA -> astA AAD43579.1 class VIRULENCE -> subclass astA -> astA AAM88299.1 class VIRULENCE -> subclass astA -> ehxA AAZ76497.1 product_name enterohemolysin -> enterohemolysin EhxA ehxA ABQ02442.1 product_name enterohemolysin -> enterohemolysin EhxA ehxA ABQ02443.1 product_name enterohemolysin -> enterohemolysin EhxA ehxA ABQ02445.1 product_name enterohemolysin -> enterohemolysin EhxA ehxA ABQ02447.1 product_name enterohemolysin -> enterohemolysin EhxA ehxA ABQ02448.1 product_name enterohemolysin -> enterohemolysin EhxA emrD3 ABQ18953.1 blacklisted_taxa Vibrio_cholerae -> kdeA ABR76310.1 blacklisted_taxa Klebsiella -> class -> EFFLUX subclass -> EFFLUX ehxA ACL51961.1 product_name enterohemolysin -> enterohemolysin EhxA emrD ACN65732.1 class -> EFFLUX subclass -> EFFLUX amvA ACQ82816.1 class -> EFFLUX subclass -> EFFLUX astA ADI59685.1 class VIRULENCE -> subclass astA -> ehxA ADZ45128.1 product_name enterohemolysin -> enterohemolysin EhxA asr BAA15331.2 blacklisted_taxa Escherichia -> arsB BAA24823.1 blacklisted_taxa Escherichia -> arsC BAA24824.1 blacklisted_taxa Escherichia, Klebsiella -> ehxA BAA31774.1 product_name enterohemolysin -> enterohemolysin EhxA fieF BAB89353.1 blacklisted_taxa Klebsiella -> fieF BAE77395.1 blacklisted_taxa Escherichia, Salmonella -> emrD BAE77620.1 blacklisted_taxa Escherichia -> class -> EFFLUX subclass -> EFFLUX arsR BAE77793.1 blacklisted_taxa Escherichia -> ehxA CAA63849.1 product_name enterohemolysin -> enterohemolysin EhxA emrD EFF04178.1 class -> EFFLUX subclass -> EFFLUX silF KGL71342.1 product_name Ag(+)/Cu(+) efflux RND transporter periplasmic metallochaperone SilF -> Cu(+)/Ag(+) efflux RND transporter periplasmic metallochaperone SilF dfrA18 WP_001031075.1 product_name trimethoprim-resistant dihydrofolate reductase Dfr18 -> trimethoprim-resistant dihydrofolate reductase DfrA18 mphK WP_003246254.1 product_name macrolide 2'-phosphotransferase MphJ -> macrolide 2'-phosphotransferase MphK blaOKP-B-6 WP_004205995.1 gene_family blaOKP -> blaOKP-B ampC WP_006178946.1 product_name CMY2/MIR/ACT/EC family class c beta-lactamase -> CMY2/MIR/ACT/EC family class C beta-lactamase blaOKP-B-8 WP_017900346.1 gene_family blaOKP -> blaOKP-B blaOKP-A-17 WP_023289605.1 gene_family blaOKP -> blaOKP-A blaOKP-B-23 WP_023318187.1 gene_family blaOKP -> blaOKP-B blaOKP-A-2 WP_032452758.1 gene_family blaOKP -> blaOKP-A blaOKP-B-1 WP_032456002.1 gene_family blaOKP -> blaOKP-B blaPAC-1 WP_034051940.1 product_name class C beta-lactamase PAC-1 -> inhibitior-resistant cephalosporin-hydrolyzing class C beta-lactamase PAC-1 subclass BETA-LACTAM -> CEPHALOSPORIN blaOKP-A-3 WP_044522859.1 gene_family blaOKP -> blaOKP-A blaOKP-A-8 WP_048334865.1 gene_family blaOKP -> blaOKP-A blaOKP-B-7 WP_057215100.1 gene_family blaOKP -> blaOKP-B ampC WP_057991970.1 product_name class C beta-lactamase -> MCA family class C beta-lactamase blaOKP-A-6 WP_060590773.1 gene_family blaOKP -> blaOKP-A ampC WP_063406924.1 product_name CMY2/MIR/ACT/EC family class c beta-lactamase -> CMY2/MIR/ACT/EC family class C beta-lactamase blaOKP-B WP_063842745.1 gene_family blaOKP -> blaOKP-B blaOKP-A-1 WP_063860896.1 gene_family blaOKP -> blaOKP-A blaOKP-A-10 WP_063860897.1 gene_family blaOKP -> blaOKP-A blaOKP-A-11 WP_063860898.1 gene_family blaOKP -> blaOKP-A blaOKP-A-12 WP_063860899.1 gene_family blaOKP -> blaOKP-A blaOKP-A-13 WP_063860900.1 gene_family blaOKP -> blaOKP-A blaOKP-A-14 WP_063860901.1 gene_family blaOKP -> blaOKP-A blaOKP-A-15 WP_063860902.1 gene_family blaOKP -> blaOKP-A blaOKP-A-16 WP_063860903.1 gene_family blaOKP -> blaOKP-A blaOKP-A-4 WP_063860904.1 gene_family blaOKP -> blaOKP-A blaOKP-A-5 WP_063860905.1 gene_family blaOKP -> blaOKP-A blaOKP-A-7 WP_063860906.1 gene_family blaOKP -> blaOKP-A blaOKP-A-9 WP_063860907.1 gene_family blaOKP -> blaOKP-A blaOKP-B-10 WP_063860908.1 gene_family blaOKP -> blaOKP-B blaOKP-B-11 WP_063860909.1 gene_family blaOKP -> blaOKP-B blaOKP-B-13 WP_063860910.1 gene_family blaOKP -> blaOKP-B blaOKP-B-17 WP_063860911.1 gene_family blaOKP -> blaOKP-B blaOKP-B-18 WP_063860912.1 gene_family blaOKP -> blaOKP-B blaOKP-B-19 WP_063860913.1 gene_family blaOKP -> blaOKP-B blaOKP-B-2 WP_063860914.1 gene_family blaOKP -> blaOKP-B blaOKP-B-20 WP_063860915.1 gene_family blaOKP -> blaOKP-B blaOKP-B-3 WP_063860916.1 gene_family blaOKP -> blaOKP-B blaOKP-B-4 WP_063860917.1 gene_family blaOKP -> blaOKP-B blaOKP-B-5 WP_063860923.1 gene_family blaOKP -> blaOKP-B blaOKP-B-9 WP_063860931.1 gene_family blaOKP -> blaOKP-B icr-Mo WP_082741435.1 class -> COLISTIN subclass -> COLISTIN blaPDC-245 WP_100831609.1 product_name class C beta-lactamase PDC-245 -> inhibitor-resistant class C beta-lactamase PDC-245 blaPDC-270 WP_109791203.1 product_name class C beta-lactamase PDC-270 -> inhibitor-resistant class C beta-lactamase PDC-270 blaPDC-322 WP_138403314.1 product_name class C beta-lactamase PDC-322 -> inhibitor-resistant class C beta-lactamase PDC-322 blaKPC-41 WP_148044419.1 product_name carbapenem-hydrolyzing class A beta-lactamase KPC-41 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-41 blaPDC-346 WP_148044438.1 product_name class C beta-lactamase PDC-346 -> inhibitor-resistant class C beta-lactamase PDC-346 blaPDC-381 WP_148044467.1 product_name class C beta-lactamase PDC-381 -> inhibitor-resistant class C beta-lactamase PDC-381 acrR_R45C WP_000101737.1 genbank_protein_accession -> AAC73566.1 product_name transcriptional regulator -> transcriptional regulator AcrR basR_G15R WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_G53A WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_G53C WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_G53E WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_G53R WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_G53S WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_G53V WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_G53W WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_L105P WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_R81L WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_R81S WP_094970923.1 genbank_protein_accession -> OZX69954.1 basR_S39I WP_094970923.1 genbank_protein_accession -> OZX69954.1 cmeR_G86A WP_002843095.1 genbank_protein_accession -> EAH9016342.1 cyaA_S352T WP_000281668.1 genbank_protein_accession -> CDJ73082.1 product_name adenylate cyclase -> adenylate cyclase CyaA fabG_Y151V WP_001718014.1 genbank_protein_accession -> EMW23334.1 product_name beta-ketoacyl-ACP reductase -> beta-ketoacyl-ACP reductase FabG fabI_F203A WP_000506490.1 genbank_protein_accession -> AAC74370.1 fabI_F203C WP_000506490.1 genbank_protein_accession -> AAC74370.1 fabI_F203L WP_000506490.1 genbank_protein_accession -> AAC74370.1 fabI_G93A WP_000506490.1 genbank_protein_accession -> AAC74370.1 fabI_G93S WP_000506490.1 genbank_protein_accession -> AAC74370.1 fabI_G93V WP_000506490.1 genbank_protein_accession -> AAC74370.1 folP_P64A WP_000764731.1 genbank_protein_accession -> GDV24718.1 product_name dihydropteroate synthase -> dihydropteroate synthase FolP folP_P64H WP_000764731.1 genbank_protein_accession -> GDV24718.1 product_name dihydropteroate synthase -> dihydropteroate synthase FolP folP_P64L WP_000764731.1 genbank_protein_accession -> GDV24718.1 product_name dihydropteroate synthase -> dihydropteroate synthase FolP folP_P64R WP_000764731.1 genbank_protein_accession -> GDV24718.1 product_name dihydropteroate synthase -> dihydropteroate synthase FolP folP_P64S WP_000764731.1 genbank_protein_accession -> GDV24718.1 product_name dihydropteroate synthase -> dihydropteroate synthase FolP gyrA_A119E WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A119S WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A119V WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A131G WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A196E WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A51V WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A67P WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A67S WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A70T WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A84P WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_A84V WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D72G WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D82G WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D82G WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D82N WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D85Y WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D87G WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D87G WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D87H WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D87K WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D87N WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D87N WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D87V WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D87Y WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D87Y WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D90A WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D90N WP_002779062.1 genbank_protein_accession -> AJW58405.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D90N WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D90T WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D90Y WP_002779062.1 genbank_protein_accession -> AJW58405.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_D90Y WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_E139A WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_G81C WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_G81C WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_G81D WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_G81H WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_G81S WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_H80P WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_L98V WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_N57K WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_P104S WP_002779062.1 genbank_protein_accession -> AJW58405.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_P104S WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_Q106H WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_Q106R WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S83A WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S83A WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S83F WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S83F WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S83I WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S83L WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S83V WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S83W WP_001281243.1 genbank_protein_accession -> AXO84158.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S83Y WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_S97P WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_T86A WP_002779062.1 genbank_protein_accession -> AJW58405.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_T86A WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_T86I WP_002779062.1 genbank_protein_accession -> AJW58405.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_T86I WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_T86K WP_002779062.1 genbank_protein_accession -> AJW58405.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_T86K WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_T86V WP_002779062.1 genbank_protein_accession -> AJW58405.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_T86V WP_002857904.1 genbank_protein_accession -> CAL35145.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrA_V73I WP_001281271.1 genbank_protein_accession -> EAB4993534.1 product_name DNA gyrase subunit A -> DNA gyrase subunit A GyrA gyrB_D426N WP_000072067.1 genbank_protein_accession -> BAE77595.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_E466D WP_000072047.1 genbank_protein_accession -> AHP21689.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_K447E WP_000072067.1 genbank_protein_accession -> BAE77595.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB subclass QUINOLONE -> NALIDIXIC ACID gyrB_R136C WP_000072067.1 genbank_protein_accession -> BAE77595.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_R136E WP_000072067.1 genbank_protein_accession -> BAE77595.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_R136G WP_000072067.1 genbank_protein_accession -> BAE77595.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_R136H WP_000072067.1 genbank_protein_accession -> BAE77595.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_R136I WP_000072067.1 genbank_protein_accession -> BAE77595.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_R136L WP_000072067.1 genbank_protein_accession -> BAE77595.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_R136S WP_000072067.1 genbank_protein_accession -> BAE77595.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_R438L WP_000072047.1 genbank_protein_accession -> AHP21689.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB gyrB_S464F WP_000072047.1 genbank_protein_accession -> AHP21689.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB subclass QUINOLONE -> CIPROFLOXACIN gyrB_S464Y WP_000072047.1 genbank_protein_accession -> AHP21689.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB subclass QUINOLONE -> CIPROFLOXACIN gyrB_Y421C WP_000072047.1 genbank_protein_accession -> AHP21689.1 product_name DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB lon_P403L WP_001295325.1 genbank_protein_accession -> EQY31068.1 marR_A70T WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_E31STOP WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_I49S WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_L78M WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_R73C WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_R73S WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_R77C WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_R77L WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_R94H WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_R94S WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_S3N WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_V45E WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR marR_V96E WP_000843414.1 genbank_protein_accession -> AAC74603.2 product_name MarR family transcriptional regulator -> transcriptional regulator MarR murA_C115D WP_000357259.1 genbank_protein_accession -> AIL15701.1 product_name UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA murA_C115E WP_000357259.1 genbank_protein_accession -> AIL15701.1 product_name UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA murA_C115S WP_000357259.1 genbank_protein_accession -> AIL15701.1 product_name UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA murA_D396N WP_000357259.1 genbank_protein_accession -> AIL15701.1 product_name UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA murA_L370I WP_000357259.1 genbank_protein_accession -> AIL15701.1 product_name UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA nfsA_G131D WP_089631889.1 genbank_protein_accession -> OYN67948.1 subclass NITROFURAN -> NITROFURANTOIN nfsA_K141STOP WP_089631889.1 genbank_protein_accession -> OYN67948.1 subclass NITROFURAN -> NITROFURANTOIN nfsA_Q44STOP WP_089631889.1 genbank_protein_accession -> OYN67948.1 subclass NITROFURAN -> NITROFURANTOIN nfsA_R133S WP_089631889.1 genbank_protein_accession -> OYN67948.1 subclass NITROFURAN -> NITROFURANTOIN nfsA_R15C WP_089631889.1 genbank_protein_accession -> OYN67948.1 subclass NITROFURAN -> NITROFURANTOIN nfsA_R203C WP_089631889.1 genbank_protein_accession -> OYN67948.1 subclass NITROFURAN -> NITROFURANTOIN nfsA_R203L WP_089631889.1 genbank_protein_accession -> OYN67948.1 subclass NITROFURAN -> NITROFURANTOIN nfsA_S33R WP_089631889.1 genbank_protein_accession -> OYN67948.1 subclass NITROFURAN -> NITROFURANTOIN ompF_G141D WP_000977920.1 genbank_protein_accession -> AAC74015.1 product_name outer membrane protein F -> outer membrane protein F OmpF ompF_G141E WP_000977920.1 genbank_protein_accession -> AAC74015.1 product_name outer membrane protein F -> outer membrane protein F OmpF parC_A108T WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_A108V WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_A56T WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_A85T WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_D111H WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_E84A WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_E84G WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_E84G WP_001281910.1 genbank_protein_accession -> EAW2725281.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_E84K WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_E84K WP_001281910.1 genbank_protein_accession -> EAW2725281.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_E84V WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_F60I WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_F60L WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_G78D WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_G78D WP_001281910.1 genbank_protein_accession -> EAW2725281.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_G78K WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_S129P WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_S57T WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_S80F WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_S80I WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_S80I WP_001281910.1 genbank_protein_accession -> EAW2725281.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_S80L WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_S80R WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_S80R WP_001281910.1 genbank_protein_accession -> EAW2725281.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_S80Y WP_001281881.1 genbank_protein_accession -> AAC76055.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_T66I WP_001281910.1 genbank_protein_accession -> EAW2725281.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parC_W106G WP_001281910.1 genbank_protein_accession -> EAW2725281.1 product_name DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC parE_A499T WP_000195318.1 genbank_protein_accession -> ATQ05934.1 product_name DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE parE_E454G WP_000195318.1 genbank_protein_accession -> ATQ05934.1 product_name DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE parE_H462Y WP_000195318.1 genbank_protein_accession -> ATQ05934.1 product_name DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE parE_M438I WP_000195318.1 genbank_protein_accession -> ATQ05934.1 product_name DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE parE_S458P WP_000195318.1 genbank_protein_accession -> ATQ05934.1 product_name DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE parE_V461G WP_000195318.1 genbank_protein_accession -> ATQ05934.1 product_name DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE parE_V514G WP_000195318.1 genbank_protein_accession -> ATQ05934.1 product_name DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE parE_V521F WP_000195318.1 genbank_protein_accession -> ATQ05934.1 product_name DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE pmrA_G15R WP_000697899.1 genbank_protein_accession -> EAB2345955.1 pmrA_G53E WP_000697899.1 genbank_protein_accession -> EAB2345955.1 pmrA_G53R WP_000697899.1 genbank_protein_accession -> EAB2345955.1 pmrA_R81C WP_000697899.1 genbank_protein_accession -> EAB2345955.1 pmrA_R81H WP_000697899.1 genbank_protein_accession -> EAB2345955.1 pmrB_A159P WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_A159V WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_C84R WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_C84Y WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_E121A WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_E121K WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_E121Q WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_E166K WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_E166K WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_G206D WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_G206R WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_G206W WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_L10P WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_L10R WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_L14F WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_L14R WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_L14S WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_L22P WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_M186I WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_N130Y WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_P94L WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_P94Q WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_P94Q WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_P94S WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_R155P WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_S124P WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_S29R WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_S305R WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_T147A WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_T147P WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_T156M WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_T156M WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_T156P WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_T92A WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_V161G WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_V161G WP_001300761.1 genbank_protein_accession -> KHH69629.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_V161L WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB pmrB_V161M WP_001212189.1 genbank_protein_accession -> EAM5131532.1 product_name two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB ptsI_V25I WP_000623140.1 genbank_protein_accession -> CDJ72759.1 product_name phosphoenolpyruvate--protein phosphotransferase -> phosphoenolpyruvate--protein phosphotransferase PtsI ramR_E160D WP_000113609.1 genbank_protein_accession -> ACH50230.1 product_name TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR ramR_G25A WP_000113609.1 genbank_protein_accession -> ACH50230.1 product_name TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR ramR_M84I WP_000113609.1 genbank_protein_accession -> ACH50230.1 product_name TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR ramR_R46P WP_000113609.1 genbank_protein_accession -> ACH50230.1 product_name TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR ramR_T18P WP_000113609.1 genbank_protein_accession -> ACH50230.1 product_name TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR ramR_T50P WP_000113609.1 genbank_protein_accession -> ACH50230.1 product_name TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR ramR_Y59H WP_000113609.1 genbank_protein_accession -> ACH50230.1 product_name TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR rpoB_H526Y WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_L533P WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_P564L WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_Q513L WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_Q513P WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_R529C WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_R529S WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_R687H WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_S531F WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_T563P WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpoB_V146F WP_000263098.1 genbank_protein_accession -> CSN35596.1 product_name DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB rpsL_K43R WP_057042458.1 genbank_protein_accession -> EAI0845362.1 product_name 30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL rpsL_K88E WP_057042458.1 genbank_protein_accession -> EAI0845362.1 product_name 30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL rpsL_K88Q WP_057042458.1 genbank_protein_accession -> EAI0845362.1 product_name 30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL rpsL_K88R WP_057042458.1 genbank_protein_accession -> EAI0845362.1 product_name 30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL soxR_G121D WP_000412428.1 genbank_protein_accession -> AAC77033.1 soxR_G121D WP_000412686.1 genbank_protein_accession -> CAD09250.1 soxR_R20H WP_000412428.1 genbank_protein_accession -> AAC77033.1 soxR_R20H WP_000412686.1 genbank_protein_accession -> CAD09250.1 soxS_A12S WP_000019358.1 genbank_protein_accession -> AAC77032.1 soxS_E52K WP_000019483.1 genbank_protein_accession -> AAL23089.1 tufA_A376S WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_A376T WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_A376V WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_E379K WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_G317D WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_L121Q WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_Q125E WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_Q125K WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_Q125R WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_Q330H WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_R231C WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_R231V WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_R234F WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_R234S WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_R334C WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_T335A WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_Y161C WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_Y161D WP_000031783.1 genbank_protein_accession -> AAC76364.1 tufA_Y161N WP_000031783.1 genbank_protein_accession -> AAC76364.1 uhpA_G97D WP_000633668.1 genbank_protein_accession -> CDJ73205.1 product_name DNA-binding response regulator -> DNA-binding response regulator UhpA uhpT_E350Q WP_000879194.1 genbank_protein_accession -> CDJ73208.1 product_name hexose phosphate transporter -> hexose phosphate transporter UhpT - AMR HMM library Changes: Total: Added 2 Total: Prev. Release 618 Total: Removed 0 Total: This Release 620 HMM Added: NF037973.1 myrA-NCBI HMM Added: NF038003.1 blaPLA_ORN_TER-NCBI HMM Modified: NF000389.2 blaPLA_ORN_TER-NCBI updated to NF000389.2 blaPFM-NCBI HMM Modified: NF033560.1 myrA-NCBI updated to NF033560.1 metallo_SslE-NCBI - Protein family changes: Total: Added 3 Total: Prev. Release 1527 Total: Removed 0 Total: This Release 1530 Family Added: - blaOKP-C Family Added: - blaOKP-D Family Added: NF037973.1 sslE Family Changed: - blaPFM updated to NF038003.1 blaPFM --------------------------------------------------------------------- Changes included in 2019-10-30.1 --------------------------------------------------------------------- This update includes backward incompatible changes to the AMRFinderPlus database format. It is compatible with AMRFinderPlus version 3.2 and above. To use this database version please update to AMRFinderPlus version 3.2. See https://github.com/ncbi/amr/wiki/Upgrading for how to upgrade and https://github.com/evolarjun/amr/wiki/AMRFinderPlus-database for information on the new database format. --organism / -O value Vibrio has been changed to Vibrio_cholerae because the blacklisted genes are common only in Vibrio_cholerae. Two erronious proteins have been removed, several HMMs have been added, and many new AMR alleles and "plus" genes. All HMM's have internal short names that have been changed to include a suffix to indicate the source (e.g., NCBI, Resfams, TIGRFAMs). Class and subclass have been defined for some parent families where they were not before. These will only be visible in AMRFinderPlus results if there was a novel sequence classified by AMRFinder above the level of the gene included in the Reference Gene Catalog. - Protein and point mutation changes: Total in prev: 6271 Total in release: 6443 Removed: 2 Added: 174 Changed: 42 Removed ltcA CAA23532.1 Removed sdeA EEZ94110.1 Added bmaE AAA23523.1 Added papG-II AAA24293.1 Added focG AAB20438.1 Added cdtA AAF81760.1 Added ibeA AAF98391.2 Added iutA AAN45165.2 Added sdeA AAS55383.1 Added emrD ACN65732.1 Added tcdR AJP10335.1 Added tcdB AJP10336.1 Added tcdE AJP10337.1 Added tcdA AJP10339.1 Added tcdC AJP10340.1 Added sfaF ASJ31253.1 Added emrD BAE77620.1 Added papG-III CAA43558.1 Added papA CAA43562.1 Added papH CAA43563.1 Added papC CAA43564.1 Added papE CAA43568.1 Added papG-I CAA43570.1 Added afaC CAA54117.1 Added afaC CAW30799.1 Added cdtB CBE05858.1 Added emrD EFF04178.1 Added sfaF EIL44824.1 Added papA ENA25238.1 Added cvaC P22522.1 Added mepA Q7A7N0.1 Added blaOXA-856 WP_001021774.1 Added blaOXA-847 WP_010793618.1 Added blaOXA-851 WP_014603442.1 Added tva(B) WP_014936356.1 Added blaOXA-848 WP_019485147.1 Added mcr-10.1 WP_023332837.1 Added blaADC-212 WP_031975357.1 Added blaADC-203 WP_032000414.1 Added blaOXA-855 WP_032061328.1 Added blaACT-74 WP_032652275.1 Added blaOXA-846 WP_033989974.1 Added blaOXA-850 WP_034006563.1 Added blaADC-215 WP_039098799.1 Added blaADC-216 WP_039211240.1 Added blaADC-219 WP_039213353.1 Added blaAQU-1 WP_042888870.1 Added blaLEN-32 WP_043875313.1 Added blaACT-75 WP_045347148.1 Added blaCMY-137 WP_053390271.1 Added blaADC-214 WP_060454527.1 Added blaADC-217 WP_060470109.1 Added blaLEN-42 WP_061154665.1 Added fosA8 WP_063277905.1 Added blaLEN-34 WP_072124806.1 Added blaLEN-43 WP_074385924.1 Added blaADC-218 WP_078216190.1 Added blaADC-213 WP_078230092.1 Added blaLEN-30 WP_080923375.1 Added blaAXC-3 WP_081330264.1 Added blaOXA-842 WP_087088911.1 Added blaADC-220 WP_087876534.1 Added blaLEN-55 WP_094917017.1 Added blaAXC-2 WP_100505522.1 Added blaLEN-41 WP_100675621.1 Added blaLEN-12 WP_110196444.1 Added blaOXA-854 WP_114158997.1 Added blaADC-199 WP_114166683.1 Added blaOXA-853 WP_114252036.1 Added blaLEN-58 WP_117122976.1 Added blaLEN-51 WP_123836928.1 Added blaACT-76 WP_126817982.1 Added blaADC-207 WP_130173437.1 Added blaADC-194 WP_133972424.1 Added blaOXA-822 WP_133973918.1 Added blaPDC-319 WP_134254706.1 Added blaLEN-39 WP_136026639.1 Added blaLEN-40 WP_136049560.1 Added blaLEN-38 WP_136086342.1 Added blaPDC-322 WP_138403314.1 Added blaOXA-894 WP_144376393.1 Added blaADC-197 WP_150823452.1 Added blaADC-198 WP_150823453.1 Added blaADC-200 WP_150823454.1 Added blaADC-201 WP_150823455.1 Added blaADC-202 WP_150823456.1 Added blaADC-204 WP_150823457.1 Added blaADC-205 WP_150823458.1 Added blaADC-206 WP_150823459.1 Added blaADC-208 WP_150823460.1 Added blaADC-209 WP_150823461.1 Added blaADC-210 WP_150823462.1 Added blaADC-211 WP_150823463.1 Added blaAXC-4 WP_150823464.1 Added blaAXC-5 WP_150823465.1 Added blaCARB-51 WP_150823466.1 Added blaCARB-52 WP_150823467.1 Added blaEBR-3 WP_150823468.1 Added blaIMP-65 WP_150823469.1 Added blaOXA-838 WP_150823470.1 Added blaOXA-839 WP_150823471.1 Added blaOXA-840 WP_150823472.1 Added blaOXA-841 WP_150823473.1 Added blaOXA-843 WP_150823474.1 Added blaOXA-844 WP_150823475.1 Added blaOXA-845 WP_150823476.1 Added blaOXA-849 WP_150823477.1 Added blaPDC-318 WP_150823478.1 Added blaPDC-320 WP_150823479.1 Added blaPDC-321 WP_150823480.1 Added blaPDC-323 WP_150823481.1 Added blaPDC-324 WP_150823482.1 Added blaPDC-325 WP_150823483.1 Added blaPDC-326 WP_150823484.1 Added blaPDC-327 WP_150823485.1 Added blaPDC-328 WP_150823486.1 Added blaPDC-329 WP_150823487.1 Added blaPDC-330 WP_150823488.1 Added blaPDC-331 WP_150823489.1 Added blaPDC-332 WP_150823490.1 Added blaPDC-384 WP_150823491.1 Added blaPDC-385 WP_150823492.1 Added blaPDC-386 WP_150823493.1 Added blaPST-2 WP_150823494.1 Added blaTEM-240 WP_150823495.1 Added mcr-3.28 WP_150823496.1 Added mcr-8.3 WP_150823497.1 Added tva(A) WP_151874537.1 Added blaACT-73 WP_152315464.1 Added blaIMP-85 WP_152315465.1 Added blaMIR-23 WP_152315466.1 Added blaNDM-25 WP_152315467.1 Added blaOXA-830 WP_152315468.1 Added blaOXA-852 WP_152315469.1 Added blaOXA-857 WP_152315470.1 Added blaOXA-858 WP_152315471.1 Added blaOXA-859 WP_152315472.1 Added blaOXA-860 WP_152315473.1 Added blaOXA-861 WP_152315474.1 Added blaOXA-862 WP_152315475.1 Added blaOXA-863 WP_152315476.1 Added blaOXA-864 WP_152315477.1 Added blaOXA-865 WP_152315478.1 Added blaOXA-866 WP_152315479.1 Added blaOXA-867 WP_152315480.1 Added blaOXA-868 WP_152315481.1 Added blaOXA-869 WP_152315482.1 Added blaOXA-870 WP_152315483.1 Added blaOXA-871 WP_152315484.1 Added blaOXA-872 WP_152315485.1 Added blaOXA-873 WP_152315486.1 Added blaOXA-874 WP_152315487.1 Added blaOXA-875 WP_152315488.1 Added blaOXA-876 WP_152315489.1 Added blaOXA-877 WP_152315490.1 Added blaOXA-878 WP_152315491.1 Added blaOXA-879 WP_152315492.1 Added blaOXA-880 WP_152315493.1 Added blaOXA-881 WP_152315494.1 Added blaOXA-882 WP_152315495.1 Added blaOXA-883 WP_152315496.1 Added blaOXA-884 WP_152315497.1 Added blaOXA-885 WP_152315498.1 Added blaOXA-886 WP_152315499.1 Added blaOXA-887 WP_152315500.1 Added blaOXA-888 WP_152315501.1 Added blaOXA-889 WP_152315502.1 Added blaOXA-890 WP_152315503.1 Added blaOXA-891 WP_152315504.1 Added blaOXA-892 WP_152315505.1 Added blaPDC-387 WP_152315506.1 Added blaPDC-388 WP_152315507.1 Added blaLEN-35 WP_152330887.1 Added blaLEN-36 WP_152330888.1 Added blaLEN-37 WP_152330889.1 Added blaSHV-4 WP_152330890.1 Changes: arsB AAA21095.1 blacklisted_taxa -> Escherichia arsC AAB09628.1 blacklisted_taxa -> Escherichia ymgB AAC74250.1 subclass ACID -> subtype BIOCIDE -> ACID emrD3 ABQ18953.1 blacklisted_taxa Vibrio -> Vibrio_cholerae arsB BAA24823.1 blacklisted_taxa -> Escherichia fieF BAB89353.1 blacklisted_taxa -> Klebsiella aac(6')-I WP_002289795.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_002293569.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_002293989.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_002328174.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_002339746.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_002373947.1 gene_family aac(6') -> aac(6')-I aac(6')-Iih WP_005880220.1 gene_family aac(6') -> aac(6')-I aac(6')-Ii WP_008265821.1 gene_family aac(6') -> aac(6')-I aac(6')-Iid WP_010720790.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_010723742.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_010727362.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_010728104.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_010736157.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_010737153.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_010750427.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_010752789.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_010768325.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_016172918.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_016177698.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_016628216.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_019722502.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_023519215.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_024635824.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_034688908.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_034700626.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_034860925.1 gene_family aac(6') -> aac(6')-I blaOXA-252 WP_037428895.1 curated_refseq_start Yes -> No genbank_cds_start 842113 -> 2724286 genbank_cds_stop 842910 -> 2725083 genbank_nucleotide_accession JTLE01000094.1 -> CP022089.2 genbank_protein_accession -> ASF15667.1 genbank_strand_orientation + -> - refseq_nucleotide_accession NG_050608.1 -> NG_066509.1 aac(6')-I WP_048603867.1 gene_family aac(6') -> aac(6')-I aac(6')-I WP_053766315.1 gene_family aac(6') -> aac(6')-I blaOXA-539 WP_071593233.1 product_name OXA-2 family class D extended-spectrum beta-lactamase OXA-539 -> OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-539 subclass BETA-LACTAM -> CEPHALOSPORIN lnu(F) WP_071846285.1 allele linH2 -> aac(6')-I WP_071846353.1 gene_family aac(6') -> aac(6')-I blaOXA-576 WP_087696200.1 curated_refseq_start Yes -> No genbank_cds_start 843910 -> 1 genbank_cds_stop 844656 -> 747 genbank_nucleotide_accession NFPA01000015.1 -> MH085550.1 genbank_protein_accession -> AWD39715.1 refseq_nucleotide_accession NG_057458.1 -> NG_066510.1 blaAQU WP_099156042.1 allele blaAQU-1 -> product_name class C beta-lactamase AQU-1 -> AQU family class C beta-lactamase blaKPC-40 WP_115470049.1 product_name carbapenem-hydrolyzing class A beta-lactamase KPC-40 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-40 blaOXA-681 WP_122630881.1 product_name OXA-2 family class D beta-lactamase OXA-681 -> OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-681 subclass BETA-LACTAM -> CEPHALOSPORIN - AMR HMM library Changes: Total: Added 10 Total: Prev. Release 608 Total: Removed 0 Total: This Release 618 HMM Added: 154989_fosA-NCBI HMM Added: NF000252.1 MsrSA-NCBI HMM Added: NF000282.2 RPH_KJ151292.1-NCBI HMM Added: NF000315.1 amicyc_ac_ApmA-NCBI HMM Added: NF028537.1 QacCGHJ-NCBI HMM Added: NF033086.2 penta_rpt_QnrA-NCBI HMM Added: NF033134.0 cmlB1_MFS-NCBI HMM Added: NF033643.1 FOX-MOX-NCBI HMM Added: NF033651.1 dipept_VanX-NCBI HMM Added: NF033653.1 blaOXA-274_like-NCBI HMM Modified: NF000004.1 vanH-D updated to NF000004.1 vanH-Sc-NCBI HMM Modified: NF000005.4 ble_BLMT updated to NF000005.4 ble_MBL-NCBI HMM Modified: NF000006.2 trim_DfrA26 updated to NF000006.2 trim_DfrA3-NCBI HMM Modified: NF000007.1 16S_rRNA_Rmt_D updated to NF000007.1 16S_rRNA_Rmt_E-NCBI HMM Modified: NF000008.1 trim_DfrA1_rpt updated to NF000008.1 trim_DfrA20-NCBI HMM Modified: NF000009.1 tet_MFS_Tcr3 updated to NF000009.1 tet_MFS_V-NCBI HMM Modified: NF000010.1 AAC_2p_Ib updated to NF000010.1 AAC_2p_Ic-NCBI HMM Modified: NF000011.2 APH_6_Ic updated to NF000011.2 APH_6_Ic_gen-NCBI HMM Modified: NF000012.1 trim_DfrI updated to NF000012.1 vanH-Ac1-NCBI HMM Modified: NF000013.1 tet_NaH_anti_35 updated to NF000013.1 tet_destruct-NCBI HMM Modified: NF000014.1 tet_prtrans_34 updated to NF000014.1 tet_redox_37-NCBI HMM Modified: NF000015.3 APH_2pp_IIa updated to NF000015.3 APH_2pp_I_a_f_h-NCBI HMM Modified: NF000016.1 AAC_6p_Im updated to NF000016.1 AAC_6p_Ip-NCBI HMM Modified: NF000017.1 linco_LnuD updated to NF000017.1 linco_LnuE-NCBI HMM Modified: NF000018.2 trim_DfrA10 updated to NF000018.2 trim_DfrA12-NCBI HMM Modified: NF000019.2 trim_DfrA3 updated to NF000019.2 trim_DfrA35-NCBI HMM Modified: NF000020.1 stregram_VatE updated to NF000020.1 stregram_VatF-NCBI HMM Modified: NF000021.4 AAC_6p_Serra updated to NF000021.4 AAC_6p_Steno-NCBI HMM Modified: NF000022.1 stregra_B_VgbA updated to NF000022.1 stregra_B_VgbB-NCBI HMM Modified: NF000023.1 qac_SMR_C updated to NF000023.1 qac_SMR_G-NCBI HMM Modified: NF000024.1 ErmS updated to NF000024.1 ErmV-NCBI HMM Modified: NF000025.1 MFS_efflux_tcmA updated to NF000025.1 MOX_CMY1_fam-NCBI HMM Modified: NF000026.1 154989_fosA updated to NF000026.1 156720500_bleO-NCBI HMM Modified: NF000027.1 156720500_bleO updated to NF000027.1 1567214_ble-NCBI HMM Modified: NF000028.1 1567214_ble updated to NF000028.1 16S_rRNA_NpmA-NCBI HMM Modified: NF000029.2 APH_9_Ib updated to NF000029.2 BlaA_Yent-NCBI HMM Modified: NF000030.1 16S_rRNA_NpmA updated to NF000030.1 16S_rRNA_Rmt_B-NCBI HMM Modified: NF000032.1 D_ala_D_ser_VanL updated to NF000032.1 D_ala_D_ser_VanN-NCBI HMM Modified: NF000033.1 vanT-L-mem updated to NF000033.1 vanW-B-NCBI HMM Modified: NF000034.1 AAC_2p_Ic updated to NF000034.1 AAC_2p_Id-NCBI HMM Modified: NF000035.1 nosihep_NshR updated to NF000035.1 penta_rpt_Qnr-NCBI HMM Modified: NF000036.1 D_ala_D_ser_VanE updated to NF000036.1 D_ala_D_ser_VanG-NCBI HMM Modified: NF000037.1 RND_perm_OqxB updated to NF000037.1 RND_permease_1-NCBI HMM Modified: NF000039.1 trim_DfrA18 updated to NF000039.1 trim_DfrA19-NCBI HMM Modified: NF000041.1 trim_DfrA19 updated to NF000041.1 trim_DfrA1_like-NCBI HMM Modified: NF000042.1 AAC_2p_Id updated to NF000042.1 AAC_2p_Ie-NCBI HMM Modified: NF000043.1 tet_MFS_P_a updated to NF000043.1 tet_MFS_Tcr3-NCBI HMM Modified: NF000044.2 APH_2pp_IIIa updated to NF000044.2 APH_2pp_IIa-NCBI HMM Modified: NF000047.1 ErmV updated to NF000047.1 EspJ_gen-NCBI HMM Modified: NF000048.1 AAC_6p_A40 updated to NF000048.1 AAC_6p_A48-NCBI HMM Modified: NF000049.1 tet_MFS_40 updated to NF000049.1 tet_MFS_42-NCBI HMM Modified: NF000050.2 AAC_6p_A29 updated to NF000050.2 AAC_6p_A30-NCBI HMM Modified: NF000051.1 macrolide_MefB updated to NF000051.1 macrolide_MefC-NCBI HMM Modified: NF000052.4 APH_9_Ia updated to NF000052.4 APH_9_Ib-NCBI HMM Modified: NF000053.2 trim_DfrA12 updated to NF000053.2 trim_DfrA13_A21-NCBI HMM Modified: NF000054.1 AAC_2p_Ie updated to NF000054.1 AAC_3-NCBI HMM Modified: NF000055.3 trim_DfrA13_A21 updated to NF000055.3 trim_DfrA18-NCBI HMM Modified: NF000056.3 penta_rpt_QnrS updated to NF000056.3 penta_rpt_QnrVC-NCBI HMM Modified: NF000059.1 tet_redox_37 updated to NF000059.1 toxin_EAST1-NCBI HMM Modified: NF000061.1 linco_LnuP updated to NF000061.1 lyase_MerB-NCBI HMM Modified: NF000062.1 ANT_6_str updated to NF000062.1 ANT_9-NCBI HMM Modified: NF000063.1 Fos_BSH_Sepi updated to NF000063.1 Fos_GSH-NCBI HMM Modified: NF000064.3 ANT_2pp_Ia updated to NF000064.3 ANT_3pp_AadA1-NCBI HMM Modified: NF000065.1 trim_DfrA3b updated to NF000065.1 trim_DfrA8-NCBI HMM Modified: NF000066.1 rifampin_ARR_Sa updated to NF000066.1 sat2-NCBI HMM Modified: NF000067.2 SMR_qac_FL updated to NF000067.2 SMR_qac_G2-NCBI HMM Modified: NF000069.1 16S_rRNA_Rmt_E updated to NF000069.1 16S_rRNA_Rmt_F-NCBI HMM Modified: NF000071.4 penta_rpt_QnrA updated to NF000071.4 penta_rpt_QnrAS-NCBI HMM Modified: NF000072.1 MFS_efflux_PexA updated to NF000072.1 MFS_efflux_tcmA-NCBI HMM Modified: NF000074.1 299782349_fosC updated to NF000074.1 299782351_fosA-NCBI HMM Modified: NF000075.1 299782351_fosA updated to NF000075.1 354827590_fosA-NCBI HMM Modified: NF000076.3 APH_2pp_Ie_IVa updated to NF000076.3 APH_2pp_If_Ih-NCBI HMM Modified: NF000077.1 Erm42 updated to NF000077.1 Erm43-NCBI HMM Modified: NF000079.1 ANT_4p_Ib updated to NF000079.1 ANT_6-NCBI HMM Modified: NF000084.1 amicyc_ac_ApmA updated to NF000084.1 arsB_Sta_pI258-NCBI HMM Modified: NF000085.1 Fos_BSH_Saur updated to NF000085.1 Fos_BSH_Sepi-NCBI HMM Modified: NF000086.1 vanY_far updated to NF000086.1 vanY_of_D-NCBI HMM Modified: NF000087.1 ErmO updated to NF000087.1 ErmS-NCBI HMM Modified: NF000088.1 viomycin_Vph updated to NF000088.1 zbmA-NCBI HMM Modified: NF000089.1 qac_MFS_AB updated to NF000089.1 qac_SMR_C-NCBI HMM Modified: NF000090.1 trans_reg_VanU updated to NF000090.1 transloc_TIR-NCBI HMM Modified: NF000091.3 D_ala_D_ser_VanG updated to NF000091.3 D_ala_D_ser_VanL-NCBI HMM Modified: NF000092.1 D_ala_D_lac_Ao2 updated to NF000092.1 D_ala_D_lac_Sc-NCBI HMM Modified: NF000093.1 D_ala_D_ser_VanN updated to NF000093.1 EreA-NCBI HMM Modified: NF000094.1 354827590_fosA updated to NF000094.1 47473_otr-NCBI HMM Modified: NF000095.1 tet_MFS_OtrB updated to NF000095.1 tet_MFS_P_a-NCBI HMM Modified: NF000096.1 stregra_B_VgbB updated to NF000096.1 stregram_VatA-NCBI HMM Modified: NF000097.1 stregram_VatC updated to NF000097.1 stregram_VatD-NCBI HMM Modified: NF000098.1 Fos_BSH_Bcer updated to NF000098.1 Fos_BSH_Saur-NCBI HMM Modified: NF000100.2 AAC_2p_IIa updated to NF000100.2 AAC_2p_IIb-NCBI HMM Modified: NF000101.1 stregram_VatA updated to NF000101.1 stregram_VatC-NCBI HMM Modified: NF000103.1 tet_ABC_AB_B updated to NF000103.1 tet_MFS_38-NCBI HMM Modified: NF000107.2 APH_4_Ia updated to NF000107.2 APH_6-NCBI HMM Modified: NF000108.1 AAC_2p_Ia updated to NF000108.1 AAC_2p_Ib-NCBI HMM Modified: NF000109.2 trim_DfrA9 updated to NF000109.2 trim_DfrB-NCBI HMM Modified: NF000110.2 AAC_6p_If updated to NF000110.2 AAC_6p_Il-NCBI HMM Modified: NF000111.1 stregram_VatD updated to NF000111.1 stregram_VatE-NCBI HMM Modified: NF000112.1 vanH-Amyco updated to NF000112.1 vanH-D-NCBI HMM Modified: NF000113.1 16S_rRNA_Rmt_F updated to NF000113.1 16S_rRNA_Rmt_G-NCBI HMM Modified: NF000114.1 16S_rRNA_Rmt_G updated to NF000114.1 16S_rRNA_Rmt_H-NCBI HMM Modified: NF000115.2 AAC_6p_Iad updated to NF000115.2 AAC_6p_Iak-NCBI HMM Modified: NF000116.1 16S_rRNA_Rmt_H updated to NF000116.1 16S_rRNA_Rmt_gen-NCBI HMM Modified: NF000118.3 AAC_6p_A31 updated to NF000118.3 AAC_6p_A34-NCBI HMM Modified: NF000119.1 linco_LnuF updated to NF000119.1 linco_LnuG-NCBI HMM Modified: NF000120.3 47473_otr updated to NF000120.3 485965_fosC-NCBI HMM Modified: NF000122.1 485965_fosC updated to NF000122.1 491618165_fosA-NCBI HMM Modified: NF000123.2 AAC_6p_A34 updated to NF000123.2 AAC_6p_A37-NCBI HMM Modified: NF000124.1 491618165_fosA updated to NF000124.1 498180014_fosA-NCBI HMM Modified: NF000125.1 498180014_fosA updated to NF000125.1 AAC_2p_IIa-NCBI HMM Modified: NF000126.2 trim_DfrA8 updated to NF000126.2 trim_DfrA9-NCBI HMM Modified: NF000127.2 trim_DfrA20 updated to NF000127.2 trim_DfrA23-NCBI HMM Modified: NF000128.1 vanH-Sc updated to NF000128.1 vanH_Agroup-NCBI HMM Modified: NF000129.1 D_ala_D_lac_Sc updated to NF000129.1 D_ala_D_lac_VanA-NCBI HMM Modified: NF000131.1 MATE_multi_MepA updated to NF000131.1 MATE_multi_NorM-NCBI HMM Modified: NF000132.2 APH_2pp_Ig updated to NF000132.2 APH_3p-NCBI HMM Modified: NF000133.1 Erm32 updated to NF000133.1 Erm37-NCBI HMM Modified: NF000134.2 trim_DfrA23 updated to NF000134.2 trim_DfrA24-NCBI HMM Modified: NF000135.2 AAC_6p_IIc updated to NF000135.2 AAC_6p_Ia_fam-NCBI HMM Modified: NF000137.2 APH_7pp_Ia updated to NF000137.2 APH_9_Ia-NCBI HMM Modified: NF000138.1 AAC_6p_Iz updated to NF000138.1 AAC_6p_Serra-NCBI HMM Modified: NF000139.2 penta_rpt_QnrD updated to NF000139.2 penta_rpt_QnrE-NCBI HMM Modified: NF000141.1 linco_LnuC updated to NF000141.1 linco_LnuD-NCBI HMM Modified: NF000142.1 vanZ-Pt updated to NF000142.1 viomycin_Vph-NCBI HMM Modified: NF000143.1 trim_DfrG updated to NF000143.1 trim_DfrI-NCBI HMM Modified: NF000144.1 D_ala_D_lac_VanF updated to NF000144.1 D_ala_D_lac_VanI-NCBI HMM Modified: NF000145.1 vanZ-F updated to NF000145.1 vanZ-Pt-NCBI HMM Modified: NF000146.2 trim_DfrA24 updated to NF000146.2 trim_DfrA26-NCBI HMM Modified: NF000147.1 stregram_VatF updated to NF000147.1 stregram_VatH-NCBI HMM Modified: NF000148.1 SMR_qac_pB8 updated to NF000148.1 Shiga_Stx1A-NCBI HMM Modified: NF000149.1 vanXY_G updated to NF000149.1 vanY_AFMPt-NCBI HMM Modified: NF000150.1 16S_rRNA_Rmt_C updated to NF000150.1 16S_rRNA_Rmt_D-NCBI HMM Modified: NF000151.1 vanH-Ac1 updated to NF000151.1 vanH-Amyco-NCBI HMM Modified: NF000152.2 AAC_6p_A37 updated to NF000152.2 AAC_6p_A40-NCBI HMM Modified: NF000153.1 linco_LnuAN2 updated to NF000153.1 linco_LnuB-NCBI HMM Modified: NF000154.1 macrolide_MefEN2 updated to NF000154.1 macrolide_MphA-NCBI HMM Modified: NF000155.1 trim_DfrC updated to NF000155.1 trim_DfrD-NCBI HMM Modified: NF000157.1 fusid_est_FusH updated to NF000157.1 glycotrans_Rgt-NCBI HMM Modified: NF000158.2 AAC_6p_Il updated to NF000158.2 AAC_6p_Im-NCBI HMM Modified: NF000159.1 trim_DfrD updated to NF000159.1 trim_DfrDGK-NCBI HMM Modified: NF000165.3 AAC_6p_Entco updated to NF000165.3 AAC_6p_IIc-NCBI HMM Modified: NF000166.1 ABCF_CarA updated to NF000166.1 ABCF_Lsa_all-NCBI HMM Modified: NF000167.1 ABCF_Lsa_all updated to NF000167.1 ABCF_Msr_all-NCBI HMM Modified: NF000168.1 ABCF_Msr_all updated to NF000168.1 ABCF_OptrA-NCBI HMM Modified: NF000169.1 ABCF_Sal updated to NF000169.1 ABCF_Vga_all-NCBI HMM Modified: NF000170.1 ABCF_Vga_all updated to NF000170.1 ABCF_producer-NCBI HMM Modified: NF000171.1 ABCF_producer updated to NF000171.1 ANT_2pp_Ia-NCBI HMM Modified: NF000181.1 ANT_4p_Ia updated to NF000181.1 ANT_4p_Ib-NCBI HMM Modified: NF000185.2 BlaEC updated to NF000185.2 BlaI_of_MRSA-NCBI HMM Modified: NF000186.1 BlaI_of_MRSA updated to NF000186.1 BlaMIR-NCBI HMM Modified: NF000187.3 BlaMIR updated to NF000187.3 BlmB-NCBI HMM Modified: NF000188.2 CARB updated to NF000188.2 CAR_gen_B3-NCBI HMM Modified: NF000191.1 CMY2 updated to NF000191.1 CfrAB-NCBI HMM Modified: NF000206.1 D_ala_D_lac updated to NF000206.1 D_ala_D_lac_Ao2-NCBI HMM Modified: NF000207.3 D_ala_D_ser updated to NF000207.3 D_ala_D_ser_VanC-NCBI HMM Modified: NF000208.1 EreA updated to NF000208.1 EreB-NCBI HMM Modified: NF000209.1 EreB updated to NF000209.1 EreD-NCBI HMM Modified: NF000216.2 blaFEZ updated to NF000216.2 blaFIM-NCBI HMM Modified: NF000218.1 FexA updated to NF000218.1 FloR-NCBI HMM Modified: NF000219.1 FloR updated to NF000219.1 FosA-NCBI HMM Modified: NF000221.4 FosA updated to NF000221.4 FosF-NCBI HMM Modified: NF000222.1 FosX updated to NF000222.1 Fos_BSH-NCBI HMM Modified: NF000224.3 AAC_6p_Acine updated to NF000224.3 AAC_6p_Entco-NCBI HMM Modified: NF000225.3 AAC_6p_Strep updated to NF000225.3 AAC_6p_Yersi-NCBI HMM Modified: NF000232.1 L2 updated to NF000232.1 LEN-NCBI HMM Modified: NF000233.2 LEN updated to NF000233.2 MATE_multi_MepA-NCBI HMM Modified: NF000235.3 linco_LnuB updated to NF000235.3 linco_LnuC-NCBI HMM Modified: NF000236.1 linco_LnuA updated to NF000236.1 linco_LnuAN2-NCBI HMM Modified: NF000237.1 MECA_PBP2A updated to NF000237.1 MECA_pure-NCBI HMM Modified: NF000239.3 MOX_CMY1_fam updated to NF000239.3 MPH_3-NCBI HMM Modified: NF000240.1 macrolide_MphC updated to NF000240.1 macrolide_MphE-NCBI HMM Modified: NF000241.1 MPH_3 updated to NF000241.1 MecI_of_mecA-NCBI HMM Modified: NF000242.1 macrolide_MphB updated to NF000242.1 macrolide_MphC-NCBI HMM Modified: NF000243.1 MecI_of_mecA updated to NF000243.1 MecI_of_mecC-NCBI HMM Modified: NF000244.1 MecI_of_mecC updated to NF000244.1 MerA-TIGRFAMs HMM Modified: NF000245.1 macrolide_MefA updated to NF000245.1 macrolide_MefB-NCBI HMM Modified: NF000246.1 macrolide_MefC updated to NF000246.1 macrolide_MefEN2-NCBI HMM Modified: NF000249.1 MexE updated to NF000249.1 MexX-Resfams HMM Modified: NF000254.1 macrolide_MphA updated to NF000254.1 macrolide_MphB-NCBI HMM Modified: NF000255.1 macrolide_MphF updated to NF000255.1 merT_RC607-NCBI HMM Modified: NF000256.1 MsrSA updated to NF000256.1 MupA-NCBI HMM Modified: NF000257.1 MupA updated to NF000257.1 MupB-NCBI HMM Modified: NF000258.1 MupB updated to NF000258.1 NimABCDEF-NCBI HMM Modified: NF000259.2 blaNDM updated to NF000259.2 blaOCH-NCBI HMM Modified: NF000261.1 NimABCDEF updated to NF000261.1 NimIJ-NCBI HMM Modified: NF000262.1 NimIJ updated to NF000262.1 NshR_TsnR-NCBI HMM Modified: NF000263.1 MATE_multi_NorM updated to NF000263.1 MECA1_pure-NCBI HMM Modified: NF000264.2 blaOCH updated to NF000264.2 blaOXA-10_like-NCBI HMM Modified: NF000265.2 OKP updated to NF000265.2 OqxA_adapt_sub-NCBI HMM Modified: NF000266.2 blaOXA-23_like updated to NF000266.2 blaOXA-24_like-NCBI HMM Modified: NF000267.2 blaOXA-2_like updated to NF000267.2 blaOXA-364_like-NCBI HMM Modified: NF000268.2 blaOXA-51_like updated to NF000268.2 blaOXA-55_like-NCBI HMM Modified: NF000269.2 blaOXA-213_like updated to NF000269.2 blaOXA-214_like-NCBI HMM Modified: NF000270.1 bla_class_D_alt updated to NF000270.1 bla_class_D_main-NCBI HMM Modified: NF000271.2 blaOXY updated to NF000271.2 blaP-NCBI HMM Modified: NF000272.1 OqxA_adapt_sub updated to NF000272.1 PRK10026.1-PRKfam HMM Modified: NF000275.2 blaPLA_ORN_TER updated to NF000275.2 blaPME-NCBI HMM Modified: NF000276.2 SMR_qac_E updated to NF000276.2 SMR_qac_FL-NCBI HMM Modified: NF000277.1 qac_SMR_G updated to NF000277.1 qac_SMR_H-NCBI HMM Modified: NF000278.1 SMR_qac_G2 updated to NF000278.1 SMR_qac_K-NCBI HMM Modified: NF000279.1 qac_SMR_H updated to NF000279.1 qac_SMR_J-NCBI HMM Modified: NF000280.1 SMR_efflux_smr updated to NF000280.1 SMR_qac_E-NCBI HMM Modified: NF000283.1 RPH_KJ151292.1 updated to NF000283.1 RTG-NCBI HMM Modified: NF000284.1 RTG updated to NF000284.1 SHV-NCBI HMM Modified: NF000285.3 SHV updated to NF000285.3 SHV_LEN_OKP-NCBI HMM Modified: NF000287.1 SMB1_fam updated to NF000287.1 SMR_efflux_smr-NCBI HMM Modified: NF000294.1 Sul1 updated to NF000294.1 Sul2-NCBI HMM Modified: NF000295.1 Sul2 updated to NF000295.1 Sul3-NCBI HMM Modified: NF000296.1 Sul3 updated to NF000296.1 Sul4-NCBI HMM Modified: NF000298.2 blaTLA updated to NF000298.2 blaTMB-NCBI HMM Modified: NF000311.1 Vat_ABCDEFH updated to NF000311.1 aadE-Cc-NCBI HMM Modified: NF000312.1 ANT_6_aadK updated to NF000312.1 ANT_6_aadS-NCBI HMM Modified: NF000318.1 rifampin_ARR_Ms updated to NF000318.1 rifampin_ARR_Sa-NCBI HMM Modified: NF000320.2 betalact_A_Burk_PenA updated to NF000320.2 betalact_A_Burk_PenI-NCBI HMM Modified: NF000321.2 betalact_A_Burk_PenI updated to NF000321.2 bla-A_Chryseo-NCBI HMM Modified: NF000322.2 blaCcrA updated to NF000322.2 blaDHA-NCBI HMM Modified: NF000323.2 blaFONA updated to NF000323.2 blaFOX-NCBI HMM Modified: NF000324.2 blaLUT updated to NF000324.2 blaMCA-NCBI HMM Modified: NF000326.1 blaR1_generic updated to NF000326.1 blaRCP-NCBI HMM Modified: NF000327.2 blaSCO updated to NF000327.2 blaSED-NCBI HMM Modified: NF000328.2 blaSED updated to NF000328.2 blaSFH-NCBI HMM Modified: NF000329.2 bla_B2_CphA updated to NF000329.2 bla_Bc_2-NCBI HMM Modified: NF000330.1 trim_DfrA1_like updated to NF000330.1 trim_DfrA1_rpt-NCBI HMM Modified: NF000331.1 trim_DfrB updated to NF000331.1 trim_DfrC-NCBI HMM Modified: NF000332.1 trim_DfrDGK updated to NF000332.1 trim_DfrE-NCBI HMM Modified: NF000333.1 trim_DfrF updated to NF000333.1 trim_DfrG-NCBI HMM Modified: NF000336.1 emrE updated to NF000336.1 erm_38_23S_MT-NCBI HMM Modified: NF000337.1 erm_SHROVE updated to NF000337.1 fomA_AB016934.1.gene6-NCBI HMM Modified: NF000338.1 fomA_AB016934.1.gene6 updated to NF000338.1 fos-Crono-NCBI HMM Modified: NF000339.2 fos-Crono updated to NF000339.2 fosA7-NCBI HMM Modified: NF000340.1 fusB updated to NF000340.1 fusC-NCBI HMM Modified: NF000341.1 fusC updated to NF000341.1 fusD-NCBI HMM Modified: NF000343.1 rif_mono_Iri updated to NF000343.1 rif_monoox-NCBI HMM Modified: NF000354.1 glycotrans_Rgt updated to NF000354.1 intimin_all-NCBI HMM Modified: NF000355.3 ribo_prot_ABC_F updated to NF000355.3 rif_mono_Iri-NCBI HMM Modified: NF000358.1 sat2 updated to NF000358.1 sat3-NCBI HMM Modified: NF000359.1 sat3 updated to NF000359.1 sat4-NCBI HMM Modified: NF000360.1 sat4 updated to NF000360.1 self_FomB_kinase-NCBI HMM Modified: NF000361.1 self_FomB_kinase updated to NF000361.1 self_GT_OleI-NCBI HMM Modified: NF000362.1 self_GT_OleI updated to NF000362.1 self_KamB-NCBI HMM Modified: NF000363.1 self_KamB updated to NF000363.1 sensor_BlaR1-NCBI HMM Modified: NF000371.1 vanH_Agroup updated to NF000371.1 vanH_gen-NCBI HMM Modified: NF000372.1 D_ala_D_lac_VanI updated to NF000372.1 D_ala_D_lac_VanM-NCBI HMM Modified: NF000373.1 vanJ updated to NF000373.1 vanR-A-NCBI HMM Modified: NF000374.1 D_ala_D_lac_VanO updated to NF000374.1 D_ala_D_ser-NCBI HMM Modified: NF000380.1 vanXY updated to NF000380.1 vanXY_G-NCBI HMM Modified: NF000383.2 blaLAP updated to NF000383.2 blaLHK-NCBI HMM Modified: NF000384.1 QacCGHJ updated to NF000384.1 RND_adapt_MexA-NCBI HMM Modified: NF000385.4 blaACT updated to NF000385.4 blaADC-NCBI HMM Modified: NF000386.2 blaOXA-10_like updated to NF000386.2 blaOXA-114_like-NCBI HMM Modified: NF000387.2 blaOXA-48_like updated to NF000387.2 blaOXA-493_like-NCBI HMM Modified: NF000388.2 blaOXA-1_like updated to NF000388.2 blaOXA-211_like-NCBI HMM Modified: NF000389.2 blaPER updated to NF000389.2 blaPLA_ORN_TER-NCBI HMM Modified: NF000390.2 blaVEB updated to NF000390.2 blaVIM-NCBI HMM Modified: NF000395.3 blaOXA-60_like updated to NF000395.3 blaOXA-61_like-NCBI HMM Modified: NF000396.2 blaGIM updated to NF000396.2 blaGOB-NCBI HMM Modified: NF000397.2 blaACC updated to NF000397.2 blaACI-NCBI HMM Modified: NF000398.2 blaBEL updated to NF000398.2 blaBES-NCBI HMM Modified: NF000399.2 blaFOX updated to NF000399.2 blaFRI-NCBI HMM Modified: NF000400.2 blaIMI updated to NF000400.2 blaIMP-NCBI HMM Modified: NF000401.1 vanR-A updated to NF000401.1 vanR-B-NCBI HMM Modified: NF000402.1 vanR-B updated to NF000402.1 vanR-C-NCBI HMM Modified: NF000403.1 vanR-C updated to NF000403.1 vanR-D-NCBI HMM Modified: NF000404.1 vanR-D updated to NF000404.1 vanR-O-NCBI HMM Modified: NF000405.1 HARLDQ_not_B3 updated to NF000405.1 HK_VanS_ACDEFG-NCBI HMM Modified: NF000406.1 MECB_PBP updated to NF000406.1 MECC_PBP-NCBI HMM Modified: NF000407.1 MECC_PBP updated to NF000407.1 MECD_PBP-NCBI HMM Modified: NF000408.1 MECA2_pure updated to NF000408.1 MECA_PBP2A-NCBI HMM Modified: NF000409.1 MECA_pure updated to NF000409.1 MECB_PBP-NCBI HMM Modified: NF000410.1 MECA1_pure updated to NF000410.1 MECA2_pure-NCBI HMM Modified: NF000411.1 Erm45 updated to NF000411.1 ErmO-NCBI HMM Modified: NF000412.1 Erm43 updated to NF000412.1 Erm45-NCBI HMM Modified: NF000413.2 blaBKC updated to NF000413.2 blaBKC_GPC-NCBI HMM Modified: NF000414.2 blaPME updated to NF000414.2 blaPOM-NCBI HMM Modified: NF000415.2 blaOXA-372_like updated to NF000415.2 blaOXA-46_like-NCBI HMM Modified: NF000417.2 blaOXA-211_like updated to NF000417.2 blaOXA-213_like-NCBI HMM Modified: NF000418.2 blaOXA-214_like updated to NF000418.2 blaOXA-229_like-NCBI HMM Modified: NF000419.2 blaCMH updated to NF000419.2 blaCPS-NCBI HMM Modified: NF000420.1 penta_rpt_QnrB updated to NF000420.1 penta_rpt_QnrC-NCBI HMM Modified: NF000421.1 penta_rpt_QnrVC updated to NF000421.1 phenyl_MerG-NCBI HMM Modified: NF000422.6 blaPDC updated to NF000422.6 blaPDC_var-NCBI HMM Modified: NF000423.2 blaSRT updated to NF000423.2 blaTEM-NCBI HMM Modified: NF000424.3 CfrAB updated to NF000424.3 D_ala_D_lac-NCBI HMM Modified: NF000425.2 blaADC updated to NF000425.2 blaAFM-NCBI HMM Modified: NF000426.2 blaSIM updated to NF000426.2 blaSME-NCBI HMM Modified: NF000427.2 blaCAU updated to NF000427.2 blaCBP-NCBI HMM Modified: NF000428.4 blaFRI updated to NF000428.4 blaFTU-NCBI HMM Modified: NF000429.2 blaOXA-63_like updated to NF000429.2 blaOXA-727_like-NCBI HMM Modified: NF000430.2 blaOXA-62_like updated to NF000430.2 blaOXA-63_like-NCBI HMM Modified: NF000431.1 AAC_6p_Ian updated to NF000431.1 AAC_6p_Ib-NCBI HMM Modified: NF000432.2 blaOXA-50_like updated to NF000432.2 blaOXA-51_like-NCBI HMM Modified: NF000434.2 blaOXA-24_like updated to NF000434.2 blaOXA-266_fam-NCBI HMM Modified: NF000435.2 blaOXA-61_like updated to NF000435.2 blaOXA-62_like-NCBI HMM Modified: NF000436.2 blaOXA-134_like updated to NF000436.2 blaOXA-143_like-NCBI HMM Modified: NF000437.2 blaFIM updated to NF000437.2 blaFONA-NCBI HMM Modified: NF000438.2 blaPOM updated to NF000438.2 blaPST-NCBI HMM Modified: NF000439.2 blaAIM updated to NF000439.2 blaALI-NCBI HMM Modified: NF000440.2 blaTHIN updated to NF000440.2 blaTLA-NCBI HMM Modified: NF000441.2 blaMUS updated to NF000441.2 blaNDM-NCBI HMM Modified: NF000442.2 blaTUS updated to NF000442.2 blaVCC-NCBI HMM Modified: NF000443.2 blaTMB updated to NF000443.2 blaTTU-NCBI HMM Modified: NF000444.2 blaEBR updated to NF000444.2 blaESP-1_fam-NCBI HMM Modified: NF000445.2 blaDIM updated to NF000445.2 blaDIM_SIM_IMP-NCBI HMM Modified: NF000446.2 blaCIA updated to NF000446.2 blaCMA-NCBI HMM Modified: NF000447.2 bla-A_Chryseo updated to NF000447.2 bla-B1-FLAV-NCBI HMM Modified: NF000448.2 blaACI updated to NF000448.2 blaACT-NCBI HMM Modified: NF000449.2 blaBIC updated to NF000449.2 blaBJP-NCBI HMM Modified: NF000450.2 bla-B1-FLAV updated to NF000450.2 bla1-NCBI HMM Modified: NF000451.2 blaBES updated to NF000451.2 blaBIC-NCBI HMM Modified: NF000452.2 blaKLUC updated to NF000452.2 blaKPC-NCBI HMM Modified: NF000453.2 blaPEDO-3_fam updated to NF000453.2 blaPER-NCBI HMM Modified: NF000454.2 blaCPS updated to NF000454.2 blaCRH-NCBI HMM Modified: NF000455.2 blaESP-1_fam updated to NF000455.2 blaFEZ-NCBI HMM Modified: NF000456.2 blaMSI-1_fam updated to NF000456.2 blaMUS-NCBI HMM Modified: NF000457.2 blaPEDO-1_fam updated to NF000457.2 blaPEDO-2_fam-NCBI HMM Modified: NF000458.2 blaPEDO-2_fam updated to NF000458.2 blaPEDO-3_fam-NCBI HMM Modified: NF000459.2 blaSPG-1_fam updated to NF000459.2 blaSPM-NCBI HMM Modified: NF000460.1 fusD updated to NF000460.1 fusF-NCBI HMM Modified: NF000461.2 blaOXA-184_like updated to NF000461.2 blaOXA-1_like-NCBI HMM Modified: NF000462.2 blaOXA-493_like updated to NF000462.2 blaOXA-50_like-NCBI HMM Modified: NF000463.2 blaOXA_Campylobacter updated to NF000463.2 blaOXY-NCBI HMM Modified: NF000464.2 blaOXA-143_like updated to NF000464.2 blaOXA-184_like-NCBI HMM Modified: NF000465.1 polymyxin_MCR1 updated to NF000465.1 polymyxin_MCR2-NCBI HMM Modified: NF000466.2 16S_rRNA_Rmt_gen updated to NF000466.2 299782349_fosC-NCBI HMM Modified: NF000467.1 FosG updated to NF000467.1 FosK-NCBI HMM Modified: NF000468.1 Erm37 updated to NF000468.1 Erm42-NCBI HMM Modified: NF000469.2 CAR_gen_B3 updated to NF000469.2 CHL_hydrolase-NCBI HMM Modified: NF000470.1 D_ala_D_lac_VanM updated to NF000470.1 D_ala_D_lac_VanO-NCBI HMM Modified: NF000471.1 vanY_of_D updated to NF000471.1 vanZ-A-NCBI HMM Modified: NF000472.1 vanY_AFMPt updated to NF000472.1 vanY_BG-NCBI HMM Modified: NF000473.1 vanY_BG updated to NF000473.1 vanY_far-NCBI HMM Modified: NF000474.1 tet_ABC_46_A updated to NF000474.1 tet_ABC_46_B-NCBI HMM Modified: NF000475.1 tet_ABC_46_B updated to NF000475.1 tet_ABC_AB_A-NCBI HMM Modified: NF000476.1 myrA updated to NF000476.1 nosihep_NshR-NCBI HMM Modified: NF000477.1 NshR_TsnR updated to NF000477.1 OKP-NCBI HMM Modified: NF000478.2 linco_LnuE updated to NF000478.2 linco_LnuF-NCBI HMM Modified: NF000479.1 zbmA updated to NF000479.1 HMM Modified: NF000480.2 PSE updated to NF000480.2 P_eth_NH2_trans-NCBI HMM Modified: NF000481.1 carbeni_gen updated to NF000481.1 chaper_CopP-NCBI HMM Modified: NF000482.1 AAC_3_XI updated to NF000482.1 AAC_6p_A10-NCBI HMM Modified: NF000483.1 BlmB updated to NF000483.1 CARB-NCBI HMM Modified: NF000485.1 TlmB updated to NF000485.1 VanC1_ser_lig-NCBI HMM Modified: NF000486.1 AAC_6p_Ip updated to NF000486.1 AAC_6p_Iz-NCBI HMM Modified: NF000487.1 stat updated to NF000487.1 stregra_B_VgbA-NCBI HMM Modified: NF000488.1 chrB updated to NF000488.1 classA_carba-NCBI HMM Modified: NF000489.1 ble_Sh updated to NF000489.1 carbeni_gen-NCBI HMM Modified: NF000490.1 chloram_CatB updated to NF000490.1 chrB-NCBI HMM Modified: NF000491.1 chloram_CatA updated to NF000491.1 chloram_CatB-NCBI HMM Modified: NF000492.1 vanH_gen updated to NF000492.1 vanJ-NCBI HMM Modified: NF000493.1 Fos_BSH updated to NF000493.1 Fos_BSH_Bcer-NCBI HMM Modified: NF000494.1 FosF updated to NF000494.1 FosG-NCBI HMM Modified: NF000495.1 FosK updated to NF000495.1 FosL-NCBI HMM Modified: NF000496.1 Fos_GSH updated to NF000496.1 HARLDQ_not_B3-NCBI HMM Modified: NF000497.1 AAC_6p_Iak updated to NF000497.1 AAC_6p_Ian-NCBI HMM Modified: NF000498.2 APH_2pp_If_Ih updated to NF000498.2 APH_2pp_Ig-NCBI HMM Modified: NF000499.1 Erm23S_rRNA_broad updated to NF000499.1 Erm32-NCBI HMM Modified: NF000500.2 blaOXA-58_like updated to NF000500.2 blaOXA-60_like-NCBI HMM Modified: NF000501.2 blaOXA-229_like updated to NF000501.2 blaOXA-22_like-NCBI HMM Modified: NF000502.2 blaOXA-85_like updated to NF000502.2 blaOXA_Campylobacter-NCBI HMM Modified: NF000503.1 fusF updated to NF000503.1 fusid_est_FusH-NCBI HMM Modified: NF000504.1 stregram_VatH updated to NF000504.1 stregram_VatI-NCBI HMM Modified: NF000505.2 blaGIL updated to NF000505.2 blaGIM-NCBI HMM Modified: NF000506.1 tet_ABC_AB_A updated to NF000506.1 tet_ABC_AB_B-NCBI HMM Modified: NF000507.1 AAC_6p_Ie updated to NF000507.1 AAC_6p_Ie_fam-NCBI HMM Modified: NF000508.1 APH_2pp_Ia updated to NF000508.1 APH_2pp_Ie_IVa-NCBI HMM Modified: NF000509.1 efflux_CmlA updated to NF000509.1 efflux_Cmx-NCBI HMM Modified: NF000510.1 efflux_Cmx updated to NF000510.1 efflux_OM_AdeC-NCBI HMM Modified: NF000511.2 blaCME updated to NF000511.2 blaCMH-NCBI HMM Modified: NF000512.2 blaSGM updated to NF000512.2 blaSIM-NCBI HMM Modified: NF000513.2 blaFTU updated to NF000513.2 blaGES-NCBI HMM Modified: NF000514.1 ABCF_OptrA updated to NF000514.1 ABCF_Sal-NCBI HMM Modified: NF000516.1 EreD updated to NF000516.1 Erm23S_rRNA_broad-NCBI HMM Modified: NF000517.2 blaCBP updated to NF000517.2 blaCDD-NCBI HMM Modified: NF000518.2 blaVCC updated to NF000518.2 blaVEB-NCBI HMM Modified: NF000519.2 blaPDC_var updated to NF000519.2 blaPEDO-1_fam-NCBI HMM Modified: NF000520.2 blaOXA-286_like updated to NF000520.2 blaOXA-2_like-NCBI HMM Modified: NF000531.2 blaTEM updated to NF000531.2 blaTHIN-NCBI HMM Modified: NF000538.0 classA_carba updated to NF000538.0 classA_firm-NCBI HMM Modified: NF007456.1 PRK10026.1 updated to NF007456.1 PRK13747.1-PRKfam HMM Modified: NF010310.2 PRK13747.1 updated to NF010310.2 PRK13752.1-PRKfam HMM Modified: NF010315.0 PRK13752.1 updated to NF010315.0 PSE-NCBI HMM Modified: NF012098.1 blaBPU updated to NF012098.1 blaCAM-NCBI HMM Modified: NF012099.1 SubclassA2 updated to NF012099.1 Sul1-NCBI HMM Modified: NF012100.0 blaVIM updated to NF012100.0 blaZ-NCBI HMM Modified: NF012101.1 blaGOB updated to NF012101.1 blaIMI-NCBI HMM Modified: NF012102.1 blaDHA updated to NF012102.1 blaDIM-NCBI HMM Modified: NF012103.0 blaGES updated to NF012103.0 blaGIL-NCBI HMM Modified: NF012137.0 bla_xUS updated to NF012137.0 ble_BLMA_gen-NCBI HMM Modified: NF012140.0 blaBJP updated to NF012140.0 blaBKC-NCBI HMM Modified: NF012141.0 blaKPC updated to NF012141.0 blaL-NCBI HMM Modified: NF012142.0 blaSME updated to NF012142.0 blaSPG-1_fam-NCBI HMM Modified: NF012143.0 SHV_LEN_OKP updated to NF012143.0 SMB1_fam-NCBI HMM Modified: NF012145.1 blaDIM_SIM_IMP updated to NF012145.1 blaEBR-NCBI HMM Modified: NF012146.1 blaB-IND-MUS updated to NF012146.1 blaB-NCBI HMM Modified: NF012147.1 blaIMP updated to NF012147.1 blaIND-NCBI HMM Modified: NF012148.0 blaKHM-HMB updated to NF012148.0 blaKLUC-NCBI HMM Modified: NF012149.0 blaIND updated to NF012149.0 blaKHM-HMB-NCBI HMM Modified: NF012150.3 blaSPM updated to NF012150.3 blaSRT-NCBI HMM Modified: NF012151.0 penta_rpt_QnrAS updated to NF012151.0 penta_rpt_QnrB-NCBI HMM Modified: NF012152.0 penta_rpt_QnrC updated to NF012152.0 penta_rpt_QnrD-NCBI HMM Modified: NF012153.1 tet_protect updated to NF012153.1 tet_protect_M-NCBI HMM Modified: NF012154.0 tet_protect_Q updated to NF012154.0 tet_prtrans_34-NCBI HMM Modified: NF012155.1 tet_protect_M updated to NF012155.1 tet_protect_M_W-NCBI HMM Modified: NF012156.1 blaP updated to NF012156.1 blaPAC-NCBI HMM Modified: NF012157.0 ANT_3pp_I updated to NF012157.0 ANT_3pp_II-NCBI HMM Modified: NF012158.1 macrolide_MphE updated to NF012158.1 macrolide_MphF-NCBI HMM Modified: NF012159.0 polymyxin_MCR2 updated to NF012159.0 polymyxin_MCR3-NCBI HMM Modified: NF012160.0 APH_6_Steno updated to NF012160.0 APH_7pp_Ia-NCBI HMM Modified: NF012161.0 bla_class_D_main updated to NF012161.0 bla_subclass_B1-NCBI HMM Modified: NF012165.0 AAC_6p_set_A updated to NF012165.0 ABCF_CarA-NCBI HMM Modified: NF012167.0 classA_firm updated to NF012167.0 cmlA_floR-NCBI HMM Modified: NF012169.0 qepA updated to NF012169.0 rRNA_meth_EmtA-NCBI HMM Modified: NF012170.0 qac_SMR_J updated to NF012170.0 qepA-NCBI HMM Modified: NF012171.0 APH_6 updated to NF012171.0 APH_6_Ic-NCBI HMM Modified: NF012172.1 FOX-MOX updated to NF012172.1 FexA-NCBI HMM Modified: NF012173.1 CMY2-MIR-ACT-EC updated to NF012173.1 CMY2-NCBI HMM Modified: NF012174.0 tet_MFS_A_B_C_D updated to NF012174.0 tet_MFS_B-NCBI HMM Modified: NF012175.1 tet_MFS_L_K_45 updated to NF012175.1 tet_MFS_OtrB-NCBI HMM Modified: NF012176.0 tet_MFS_38 updated to NF012176.0 tet_MFS_40-NCBI HMM Modified: NF012177.1 tet_MFS_42 updated to NF012177.1 tet_MFS_43-NCBI HMM Modified: NF012178.0 tet_MFS_V updated to NF012178.0 tet_MFS_Y-NCBI HMM Modified: NF012180.1 tet_MFS_43 updated to NF012180.1 tet_MFS_45-NCBI HMM Modified: NF012183.0 tet_MFS_K updated to NF012183.0 tet_MFS_L-NCBI HMM Modified: NF012184.0 tet_MFS_45 updated to NF012184.0 tet_MFS_A-NCBI HMM Modified: NF012185.0 tet_MFS_L updated to NF012185.0 tet_MFS_L_K_45-NCBI HMM Modified: NF012186.0 tet_MFS_D updated to NF012186.0 tet_MFS_E-NCBI HMM Modified: NF012187.0 tet_MFS_E updated to NF012187.0 tet_MFS_G-NCBI HMM Modified: NF012188.1 tet_MFS_Y updated to NF012188.1 tet_NaH_anti_35-NCBI HMM Modified: NF012190.1 tet_MFS_B updated to NF012190.1 tet_MFS_C-NCBI HMM Modified: NF012191.0 tet_MFS_C updated to NF012191.0 tet_MFS_D-NCBI HMM Modified: NF012192.0 tet_MFS_G updated to NF012192.0 tet_MFS_H-NCBI HMM Modified: NF012193.0 tet_MFS_A updated to NF012193.0 tet_MFS_A_B_C_D-NCBI HMM Modified: NF012194.0 tet_MFS_J updated to NF012194.0 tet_MFS_K-NCBI HMM Modified: NF012195.0 tet_MFS_H updated to NF012195.0 tet_MFS_H_J-NCBI HMM Modified: NF012199.0 cml_V_MFS updated to NF012199.0 cmx_cmrA-NCBI HMM Modified: NF012202.0 ble_MBL updated to NF012202.0 ble_Sh-NCBI HMM Modified: NF012203.0 cmlB1_MFS updated to NF012203.0 cml_V_MFS-NCBI HMM Modified: NF012207.0 tet_MFS_H_J updated to NF012207.0 tet_MFS_J-NCBI HMM Modified: NF012212.0 ANT_9 updated to NF012212.0 APH_2pp_IIIa-NCBI HMM Modified: NF012213.0 VanC1_ser_lig updated to NF012213.0 VarG_fam_MBL-NCBI HMM Modified: NF012214.1 D_ala_D_ser_VanC updated to NF012214.1 D_ala_D_ser_VanE-NCBI HMM Modified: NF012215.1 D_ala_D_lac_VanD updated to NF012215.1 D_ala_D_lac_VanF-NCBI HMM Modified: NF012216.1 D_ala_D_lac_VanB updated to NF012216.1 D_ala_D_lac_VanD-NCBI HMM Modified: NF012217.1 D_ala_D_lac_VanA updated to NF012217.1 D_ala_D_lac_VanB-NCBI HMM Modified: NF012218.0 erm_38_23S_MT updated to NF012218.0 erm_A_23S_MT-NCBI HMM Modified: NF012219.1 erm_C_23S_MT updated to NF012219.1 erm_F_23S_MT-NCBI HMM Modified: NF012220.1 erm_B_23S_MT updated to NF012220.1 erm_C_23S_MT-NCBI HMM Modified: NF012222.1 erm_A_23S_MT updated to NF012222.1 erm_B_23S_MT-NCBI HMM Modified: NF012223.0 erm_F_23S_MT updated to NF012223.0 erm_SHROVE-NCBI HMM Modified: NF012224.1 blaSFH updated to NF012224.1 blaSFH_gen-NCBI HMM Modified: NF012225.0 blaSFH_gen updated to NF012225.0 blaSGM-NCBI HMM Modified: NF012229.1 bla_class_B_core updated to NF012229.1 bla_class_C-NCBI HMM Modified: NF028535.0 ANT_4p_II updated to NF028535.0 ANT_4p_Ia-NCBI HMM Modified: NF032892.0 fosA7 updated to NF032892.0 fosA8-NCBI HMM Modified: NF032894.1 APH_3pp_Ia updated to NF032894.1 APH_3pp_Ib-NCBI HMM Modified: NF032895.1 APH_3pp_Ib updated to NF032895.1 APH_4_Ia-NCBI HMM Modified: NF032896.1 APH_3pp updated to NF032896.1 APH_3pp_Ia-NCBI HMM Modified: NF032897.1 APH_3p_V updated to NF032897.1 APH_3p_VI-NCBI HMM Modified: NF032898.1 APH_3p_II updated to NF032898.1 APH_3p_IIIa-NCBI HMM Modified: NF033059.2 APH_3p_I updated to NF033059.2 APH_3p_II-NCBI HMM Modified: NF033060.0 blaBCL updated to NF033060.0 blaBEL-NCBI HMM Modified: NF033061.1 ANT_4p_I updated to NF033061.1 ANT_4p_II-NCBI HMM Modified: NF033062.0 APH_3p_VI updated to NF033062.0 APH_3p_VIII-NCBI HMM Modified: NF033063.0 APH_3p_XV updated to NF033063.0 APH_3pp-NCBI HMM Modified: NF033064.0 APH_3p_IIIa updated to NF033064.0 APH_3p_IVa-NCBI HMM Modified: NF033065.0 APH_3p_IVa updated to NF033065.0 APH_3p_V-NCBI HMM Modified: NF033066.0 APH_3p_VIII updated to NF033066.0 APH_3p_VIIa-NCBI HMM Modified: NF033067.1 APH_3p_VIIa updated to NF033067.1 APH_3p_XV-NCBI HMM Modified: NF033068.1 APH_3p updated to NF033068.1 APH_3p_A16-NCBI HMM Modified: NF033074.0 AAC_6p_Ib updated to NF033074.0 AAC_6p_Id-NCBI HMM Modified: NF033075.0 AAC_6p_Steno updated to NF033075.0 AAC_6p_Strep-NCBI HMM Modified: NF033076.0 AAC_6p_Yersi updated to NF033076.0 AAC_6p_set_A-NCBI HMM Modified: NF033077.0 AAC_6p_A30 updated to NF033077.0 AAC_6p_A31-NCBI HMM Modified: NF033078.2 AAC_6p_Ia_fam updated to NF033078.2 AAC_6p_Iad-NCBI HMM Modified: NF033080.0 AAC_3_II updated to NF033080.0 AAC_3_IV-NCBI HMM Modified: NF033081.0 AAC_3_IV updated to NF033081.0 AAC_3_VIII-NCBI HMM Modified: NF033082.0 AAC_3 updated to NF033082.0 AAC_3_I-NCBI HMM Modified: NF033083.0 AAC_3_I updated to NF033083.0 AAC_3_II-NCBI HMM Modified: NF033084.2 ANT_6 updated to NF033084.2 ANT_6_aadK-NCBI HMM Modified: NF033085.1 bla_class_C updated to NF033085.1 bla_class_D_alt-NCBI HMM Modified: NF033087.1 bla_subclass_B2 updated to NF033087.1 bla_subclass_B3-NCBI HMM Modified: NF033088.1 bla_subclass_B1 updated to NF033088.1 bla_subclass_B2-NCBI HMM Modified: NF033089.1 blaCTX-M updated to NF033089.1 blaCcrA-NCBI HMM Modified: NF033090.1 HK_VanS_B updated to NF033090.1 HK_VanS_O-NCBI HMM Modified: NF033091.0 HK_VanS_ACDEFG updated to NF033091.0 HK_VanS_B-NCBI HMM Modified: NF033094.0 HK_VanS_O updated to NF033094.0 L2-NCBI HMM Modified: NF033095.1 bla_Bc_2 updated to NF033095.1 bla_CblA-NCBI HMM Modified: NF033096.1 bla1 updated to NF033096.1 blaACC-NCBI HMM Modified: NF033098.1 bla_CblA updated to NF033098.1 bla_CepA-NCBI HMM Modified: NF033099.1 bla_Exo updated to NF033099.1 bla_class_A-NCBI HMM Modified: NF033100.1 bla_CfxA updated to NF033100.1 bla_Exo-NCBI HMM Modified: NF033101.0 blaL updated to NF033101.0 blaL1-NCBI HMM Modified: NF033102.1 bla_CepA updated to NF033102.1 bla_CfxA-NCBI HMM Modified: NF033103.1 bla_class_A updated to NF033103.1 bla_class_B_core-NCBI HMM Modified: NF033104.0 blaOXA-46_like updated to NF033104.0 blaOXA-48_like-NCBI HMM Modified: NF033105.1 bla_subclass_B3 updated to NF033105.1 bla_xUS-NCBI HMM Modified: NF033106.1 blaL1 updated to NF033106.1 blaLAP-NCBI HMM Modified: NF033107.1 blaB updated to NF033107.1 blaBBI-NCBI HMM Modified: NF033108.1 sensor_BlaR1 updated to NF033108.1 sensor_MecR1-NCBI HMM Modified: NF033109.1 sensor_MecR1 updated to NF033109.1 stat-NCBI HMM Modified: NF033111.2 tet_monoox_X updated to NF033111.2 tet_protect-NCBI HMM Modified: NF033112.0 APH_3p_A16 updated to NF033112.0 APH_3p_I-NCBI HMM Modified: NF033114.1 phos_trans_CPT updated to NF033114.1 poly_MCR3_broad-NCBI HMM Modified: NF033115.1 dipept_VanX updated to NF033115.1 efflux_CmlA-NCBI HMM Modified: NF033117.2 vanR_ACDEGLN updated to NF033117.2 vanR_FM-NCBI HMM Modified: NF033118.1 vanR-O updated to NF033118.1 vanR_ACDEGLN-NCBI HMM Modified: NF033120.0 vanR_FM updated to NF033120.0 vanT-CELN-NCBI HMM Modified: NF033122.1 vanW-B updated to NF033122.1 vanW-G-NCBI HMM Modified: NF033123.1 vanW-G updated to NF033123.1 vanW-gen-NCBI HMM Modified: NF033125.2 vanZ-A updated to NF033125.2 vanZ-F-NCBI HMM Modified: NF033126.1 ANT_3pp_AadA1 updated to NF033126.1 ANT_3pp_AadA3-NCBI HMM Modified: NF033127.1 ANT_3pp_AadA3 updated to NF033127.1 ANT_3pp_I-NCBI HMM Modified: NF033128.2 vanW-gen updated to NF033128.2 vanXY-NCBI HMM Modified: NF033129.1 macro_glyco_Mgt updated to NF033129.1 macrolide_MefA-NCBI HMM Modified: NF033130.1 AAC_6p_A48 updated to NF033130.1 AAC_6p_A49-NCBI HMM Modified: NF033131.1 vanT-G-Cterm updated to NF033131.1 vanT-L-cat-NCBI HMM Modified: NF033132.1 vanT-CELN updated to NF033132.1 vanT-G-Cterm-NCBI HMM Modified: NF033133.1 vanT-L-cat updated to NF033133.1 vanT-L-mem-NCBI HMM Modified: NF033135.1 cmx_cmrA updated to NF033135.1 coreg_MerD-NCBI HMM Modified: NF033136.1 SMR_qac_K updated to NF033136.1 SMR_qac_bcrB-NCBI HMM Modified: NF033137.0 SMR_qac_int updated to NF033137.0 SMR_qac_pB8-NCBI HMM Modified: NF033139.1 blaZ updated to NF033139.1 blaZ_gen-NCBI HMM Modified: NF033140.0 blaZ_mecC_type updated to NF033140.0 bla_B2_CphA-NCBI HMM Modified: NF033141.0 blaZ_gen updated to NF033141.0 blaZ_mecC_type-NCBI HMM Modified: NF033142.1 efflux_OM_AdeC updated to NF033142.1 emrE-Resfams HMM Modified: NF033144.1 rifampin_ARR updated to NF033144.1 rifampin_ARR_Ms-NCBI HMM Modified: NF033145.1 rif_monoox updated to NF033145.1 rifampin_ARR-NCBI HMM Modified: NF033148.1 tet_protect_M_W updated to NF033148.1 tet_protect_Q-NCBI HMM Modified: NF033149.0 CHL_hydrolase updated to NF033149.0 CMY2-MIR-ACT-EC-NCBI HMM Modified: NF033150.1 AAC_6p_A49 updated to NF033150.1 AAC_6p_Acine-NCBI HMM Modified: NF033151.0 AAC_6p_A10 updated to NF033151.0 AAC_6p_A29-NCBI HMM Modified: NF033152.0 BlaA_Yent updated to NF033152.0 BlaEC-NCBI HMM Modified: NF033156.1 ble_BLMA_gen updated to NF033156.1 ble_BLMT-NCBI HMM Modified: NF033159.0 blaPAC updated to NF033159.0 blaPAU-NCBI HMM Modified: NF033174.0 blaPSV updated to NF033174.0 blaR1_generic-NCBI HMM Modified: NF033180.1 AAC_3_VIII updated to NF033180.1 AAC_3_VIa-NCBI HMM Modified: NF033182.0 linco_LnuG updated to NF033182.0 linco_LnuP-NCBI HMM Modified: NF033204.1 blaRUB updated to NF033204.1 blaSCO-NCBI HMM Modified: NF033209.1 16S_rRNA_Rmt_B updated to NF033209.1 16S_rRNA_Rmt_C-NCBI HMM Modified: NF033211.1 blaCRH updated to NF033211.1 blaCSA-NCBI HMM Modified: NF033220.1 ANT_3pp_II updated to NF033220.1 ANT_4p_I-NCBI HMM Modified: NF033221.1 aadE-Cc updated to NF033221.1 acid_shock_Asr-NCBI HMM Modified: NF033374.6 AAC_6p_Id updated to NF033374.6 AAC_6p_Ie-NCBI HMM Modified: NF033375.2 penta_rpt_QnrE updated to NF033375.2 penta_rpt_QnrS-NCBI HMM Modified: NF033378.1 MECD_PBP updated to NF033378.1 MFS_efflux_PexA-NCBI HMM Modified: NF033386.1 blaARL updated to NF033386.1 blaAXC-NCBI HMM Modified: NF033387.1 ANT_6_aadS updated to NF033387.1 ANT_6_str-NCBI HMM Modified: NF033398.1 rRNA_meth_EmtA updated to NF033398.1 ribo_prot_ABC_F-NCBI HMM Modified: NF033405.1 FosL updated to NF033405.1 FosX-NCBI HMM Modified: NF033406.1 blaMCA updated to NF033406.1 blaMSI-1_fam-NCBI HMM Modified: NF033408.5 polymyxin_MCR3 updated to NF033408.5 polymyxin_MCR4-NCBI HMM Modified: NF033409.0 poly_MCR3_broad updated to NF033409.0 polymyxin_MCR1-NCBI HMM Modified: NF033462.1 polymyxin_MCR4 updated to NF033462.1 polymyxin_MCR5-NCBI HMM Modified: NF033463.1 polymyxin_MCR5 updated to NF033463.1 polymyxin_MCR6-NCBI HMM Modified: NF033466.0 blaRCP updated to NF033466.0 blaRHO-NCBI HMM Modified: NF033467.0 blaAQU updated to NF033467.0 blaARL-NCBI HMM Modified: NF033468.1 stregram_VatI updated to NF033468.1 tet_ABC_46_A-NCBI HMM Modified: NF033469.1 SMR_qac_bcrB updated to NF033469.1 SMR_qac_bcrC-NCBI HMM Modified: NF033470.1 SMR_qac_bcrC updated to NF033470.1 SMR_qac_int-NCBI HMM Modified: NF033472.1 AAC_2p_IIb updated to NF033472.1 AAC_2p_Ia-NCBI HMM Modified: NF033473.1 trim_DfrE updated to NF033473.1 trim_DfrF-NCBI HMM Modified: NF033476.1 tet_destruct updated to NF033476.1 tet_monoox_X-NCBI HMM Modified: NF033502.0 Sul4 updated to NF033502.0 TlmB-NCBI HMM Modified: NF033509.1 blaOXA-22_like updated to NF033509.1 blaOXA-23_like-NCBI HMM Modified: NF033555.1 lyase_MerB updated to NF033555.1 macro_glyco_Mgt-NCBI HMM Modified: NF033560.1 merT_RC607 updated to NF033560.1 myrA-NCBI HMM Modified: NF033565.0 trans_MerF updated to NF033565.0 trans_reg_VanU-NCBI HMM Modified: NF033568.1 blaROB updated to NF033568.1 blaRUB-NCBI HMM Modified: NF033569.1 blaLHK updated to NF033569.1 blaLUT-NCBI HMM Modified: NF033574.1 VarG_fam_MBL updated to NF033574.1 Vat_ABCDEFH-NCBI HMM Modified: NF033575.1 blaRHO updated to NF033575.1 blaROB-NCBI HMM Modified: NF033582.2 blaALI updated to NF033582.2 blaAQU-NCBI HMM Modified: NF033584.1 blaPST updated to NF033584.1 blaPSV-NCBI HMM Modified: NF033585.1 blaTTU updated to NF033585.1 blaTUS-NCBI HMM Modified: NF033612.0 AAC_3_VIa updated to NF033612.0 AAC_3_XI-NCBI HMM Modified: NF033613.1 blaOXA-576_like updated to NF033613.1 blaOXA-58_like-NCBI HMM Modified: NF033614.1 APH_6_Ic_gen updated to NF033614.1 APH_6_Steno-NCBI HMM Modified: NF033626.1 blaBKC_GPC updated to NF033626.1 blaBPU-NCBI HMM Modified: NF033627.3 intimin_all updated to NF033627.3 intimin_alpha-NCBI HMM Modified: NF033636.1 acid_shock_Asr updated to NF033636.1 adeC-adeK-oprM-Resfams HMM Modified: NF033637.1 transloc_TIR updated to NF033637.1 transport_merC-NCBI HMM Modified: NF033639.1 intimin_alpha updated to NF033639.1 linco_LnuA-NCBI HMM Modified: NF033646.1 toxin_EAST1 updated to NF033646.1 trans_MerF-NCBI HMM Modified: NF033648.1 blaOXA-274_like updated to NF033648.1 blaOXA-286_like-NCBI HMM Modified: NF033658.1 Shiga_Stx1A updated to NF033658.1 Shiga_Stx1B-NCBI HMM Modified: NF033659.0 Shiga_Stx1B updated to NF033659.0 Shiga_Stx2A-NCBI HMM Modified: NF033660.0 Shiga_Stx2B updated to NF033660.0 SubclassA2-NCBI HMM Modified: NF033661.1 Shiga_Stx2A updated to NF033661.1 Shiga_Stx2B-NCBI HMM Modified: NF033666.1 blaOXA-727_like updated to NF033666.1 blaOXA-85_like-NCBI HMM Modified: NF033667.1 blaOXA-55_like updated to NF033667.1 blaOXA-576_like-NCBI HMM Modified: NF033669.1 polymyxin_MCR8 updated to NF033669.1 polymyxin_MCR9-NCBI HMM Modified: NF033670.1 polymyxin_MCR6 updated to NF033670.1 polymyxin_MCR7-NCBI HMM Modified: NF033671.1 polymyxin_MCR7 updated to NF033671.1 polymyxin_MCR8-NCBI HMM Modified: NF033692.1 APH_2pp_I_a_f_h updated to NF033692.1 APH_2pp_Ia-NCBI HMM Modified: NF033693.0 AAC_6p_Ie_fam updated to NF033693.0 AAC_6p_If-NCBI HMM Modified: NF033698.1 blaCSA updated to NF033698.1 blaCTX-M-NCBI HMM Modified: NF033700.1 blaCMA updated to NF033700.1 blaCME-NCBI HMM Modified: NF033702.0 blaOXA-12_like updated to NF033702.0 blaOXA-134_like-NCBI HMM Modified: NF033714.1 blaBBI updated to NF033714.1 blaBCL-NCBI HMM Modified: NF033727.1 chaperon_ArsD updated to NF033727.1 chloram_CatA-NCBI HMM Modified: NF033736.1 blaAFM updated to NF033736.1 blaAIM-NCBI HMM Modified: NF033781.1 chaper_CopP updated to NF033781.1 chaperon_ArsD-NCBI HMM Modified: NF033783.1 coreg_MerD updated to NF033783.1 cyto_nec_fctrs-NCBI HMM Modified: NF033784.1 transport_merC updated to NF033784.1 trim_DfrA10-NCBI HMM Modified: NF033786.1 phenyl_MerG updated to NF033786.1 phos_trans_CPT-NCBI HMM Modified: NF033815.0 blaOXA-364_like updated to NF033815.0 blaOXA-372_like-NCBI HMM Modified: NF033818.0 blaOXA-114_like updated to NF033818.0 blaOXA-12_like-NCBI HMM Modified: NF033834.1 RND_adapt_MexA updated to NF033834.1 RND_perm_OqxB-NCBI HMM Modified: NF033836.1 polymyxin_MCR9 updated to NF033836.1 qac_MFS_AB-NCBI HMM Modified: NF033851.1 trim_DfrA35 updated to NF033851.1 trim_DfrA36-NCBI HMM Modified: NF033866.1 blaCDD updated to NF033866.1 blaCIA-NCBI HMM Modified: NF033867.1 blaPAU updated to NF033867.1 blaPDC-NCBI HMM Modified: NF033868.0 trim_DfrA36 updated to NF033868.0 trim_DfrA3b-NCBI HMM Modified: NF033877.0 arsB_Sta_pI258 updated to NF033877.0 betalact_A_Burk_PenA-NCBI HMM Modified: NF033895.1 blaCAM updated to NF033895.1 blaCAU-NCBI HMM Modified: NF033929.1 blaAXC updated to NF033929.1 blaB-IND-MUS-NCBI HMM Modified: NF033933.0 fosA8 updated to NF033933.0 fusB-NCBI HMM Modified: TIGR02052.1 TIGR02052 updated to TIGR02052.1 MexE-Resfams HMM Modified: TIGR02053.1 TIGR02053 updated to TIGR02053.1 MerP-TIGRFAMs - Protein family changes: Total: Added 28 Total: Prev. Release 1499 Total: Removed 0 Total: This Release 1527 Family Added: hmm_id #fam_id Family Added: - afaC Family Added: - bin_CdtA Family Added: - bin_CdtB Family Added: - bmaE Family Added: - cvaC Family Added: - emrD Family Added: - focG Family Added: - ibeA Family Added: - iutA Family Added: - mcr-10 Family Added: - papA Family Added: - papC Family Added: - papE Family Added: - papG Family Added: - papG-I Family Added: - papG-II Family Added: - papG-III Family Added: - papH Family Added: - sfaF Family Added: - tcdA Family Added: - tcdB Family Added: - tcdC Family Added: - tcdE Family Added: - tcdR Family Added: - tcd_gen Family Added: - tva(A) Family Added: - tva(B) Family Changed: - blaOXA-266_fam updated to NF033653.1 blaOXA-266_fam --------------------------------------------------------------------- Changes included in 2019-09-06.1 --------------------------------------------------------------------- This release just removes two accidentally included "plus" proteins. We suggest you switch to AMRFinderPlus. See https://github.com/ncbi/amr/wiki for information an how to install since we will be dropping support for this version of AMRFinder soon. - Protein changes: Total: Added 0 Total: Prev. Release 5984 Total: Removed 2 Total: This Release 5982 Protein Removed: AAB91079.1 bind_CopB copper-binding_protein_CopB Protein Removed: BAB62907.1 cofA type_IV_pilus_CFA/III_major_pilin --------------------------------------------------------------------- Changes included in 2019-09-6.1 --------------------------------------------------------------------- This release removes three erroniously included proteins that were provided by collaborators, but accidentally released before review by curators. these sequences do not match the family, gene symbol, or protein name of the virulence and stress response families to which they had been added. There are no other changes. We will add controls to the database publication system to programmatically require that curators have manually reviewed all protein sequences before they become public. - Reference Gene Catalog protein and allele changes: Total in prev: 6274 Total in release: 6271 Removed: 3 Added: 0 Changed: 0 Removed copB AAB91079.1 Removed aaiC AHW84565.1 Removed cofA BAB62907.1 --------------------------------------------------------------------- Changes included in 2019-08-27.1 --------------------------------------------------------------------- This release includes a new database file to correspond with AMRFinderPlus version 3.1 that includes information for blacklisting of a few "plus" proteins common in some organisms that are interesting when found in others. This release also includes the usual new AMR genes and alleles; the fixing of some typos; removal of a redundant point mutation reference sequence; and the addition, reoorganization, and renaming of some "plus" genes. - Reference Gene Catalog protein and allele changes: Total in prev: 6110 Total in release: 6274 Removed: 18 Added: 182 Changed: 33 Removed emrD3 WP_000850833.1 Removed blaOXA-671 WP_016660101.1 Removed arsB-mob WP_063116263.1 Removed gyrA_A67S WP_001281242.1 Removed gyrA_A84P WP_001281242.1 Removed gyrA_D87G WP_001281242.1 Removed gyrA_D87H WP_001281242.1 Removed gyrA_D87N WP_001281242.1 Removed gyrA_D87V WP_001281242.1 Removed gyrA_D87Y WP_001281242.1 Removed gyrA_G81C WP_001281242.1 Removed gyrA_H80P WP_001281242.1 Removed gyrA_N57K WP_001281242.1 Removed gyrA_Q106H WP_001281242.1 Removed gyrA_S83F WP_001281242.1 Removed gyrA_S83I WP_001281242.1 Removed gyrA_S83L WP_001281242.1 Removed gyrA_S83W WP_001281242.1 Added arsB AAA21095.1 Added arsC AAA21096.1 Added arsR AAA25636.1 Added arsB AAA25637.1 Added copC AAA25808.1 Added arsR AAA27587.1 Added arsB AAA27588.1 Added arsR AAB09624.1 Added arsC AAB09628.1 Added arsC AAB42203.1 Added arsB AAB42204.1 Added ipaH9.8 AAC23714.1 Added pic AAD23953.1 Added efa1 AAD49229.2 Added iha AAG55323.1 Added stb AAK29747.1 Added efa1 AAL57562.1 Added pic AAN78833.1 Added iha AAN82058.1 Added cif AAQ07241.1 Added iha AAT68782.1 Added efa1 AAV91321.1 Added sab AAZ76500.1 Added senB AAZ89288.1 Added iha ABB17254.1 Added emrD3 ABQ18953.1 Added kdeA ABR76310.1 Added lmrC ABX00624.1 Added iha ACB20136.1 Added iha ACD08748.1 Added amvA ACQ82816.1 Added ipaH4 ADA74402.1 Added iha ADI47068.1 Added iha ADN47767.1 Added arsR ADZ44504.1 Added iha AEQ14190.1 Added stb AET14866.1 Added arsR AET17094.1 Added pic AFS72825.1 Added iha AFS75030.1 Added asr BAA15331.2 Added arsB BAA24823.1 Added arsC BAA24824.1 Added espK BAB34991.1 Added fieF BAB89353.1 Added fieF BAE77395.1 Added arsR BAE77793.1 Added cif BAG66370.1 Added iha BAI27255.1 Added efa1 BAI32294.1 Added iha CAC39288.1 Added efa1 CAC81883.1 Added efa1 CAD30848.1 Added stb CAD87835.1 Added iha CAE55782.1 Added efa1 CAI43818.1 Added hlyA-alpha CAQ77251.1 Added iha CAR09712.2 Added pic CAU99295.1 Added iha CBW53086.1 Added ipaH5 EID63069.1 Added fosB WP_000920239.1 Added dfrA36 WP_000949574.1 Added mphM WP_001041372.1 Added cfr(B) WP_002405682.1 Added mphK WP_003246254.1 Added blaPDC-374 WP_003454242.1 Added tet(56) WP_003635403.1 Added blaCDD-1 WP_009901927.1 Added mphH WP_015776248.1 Added erm(49) WP_019728092.1 Added blaCDD-2 WP_021361759.1 Added mphN WP_024127776.1 Added tet(X) WP_024160783.1 Added blaPDC-361 WP_031638595.1 Added tet(G) WP_032489471.1 Added vga(E) WP_032495718.1 Added blaACT-72 WP_045895620.1 Added blaACT-70 WP_047364854.1 Added blaACT-69 WP_048209719.1 Added ble WP_063842967.1 Added blaOXA-671 WP_081401608.1 Added icr-Mo WP_082741435.1 Added blaOXA-653 WP_087554513.1 Added tet(X) WP_094309310.1 Added blaMOX-13 WP_096807444.1 Added blaFOX-15 WP_096807445.1 Added blaCMY-157 WP_096807446.1 Added blaIMP-69 WP_099156051.1 Added blaPDC-249 WP_104009845.1 Added blaACT-58 WP_111965422.1 Added blaACT-62 WP_111967096.1 Added blaACT-63 WP_112780466.1 Added blaOXA-727 WP_114272532.1 Added blaOXA-731 WP_116786833.1 Added blaOXA-728 WP_116786835.1 Added blaPDC-367 WP_121286063.1 Added blaPDC-364 WP_121347819.1 Added blaFLC-1 WP_123061077.1 Added blaPDC-371 WP_126118969.1 Added blaPDC-353 WP_128550481.1 Added blaVIM-67 WP_142875125.1 Added blaADC-196 WP_145850033.1 Added blaAQU WP_148044401.1 Added blaAQU WP_148044402.1 Added dfrA29 WP_148044403.1 Added blaCAM-1 WP_148044405.1 Added blaCMY-165 WP_148044406.1 Added blaCMY-166 WP_148044407.1 Added blaCMY-167 WP_148044408.1 Added blaCTX-M-227 WP_148044409.1 Added blaCTX-M-228 WP_148044410.1 Added blaCTX-M-229 WP_148044411.1 Added blaDHA-29 WP_148044412.1 Added blaGES-42 WP_148044413.1 Added blaGES-43 WP_148044414.1 Added blaIMP-82 WP_148044416.1 Added blaIMP-83 WP_148044417.1 Added blaIMP-84 WP_148044418.1 Added blaKPC-41 WP_148044419.1 Added blaKPC-45 WP_148044420.1 Added blaKPC-46 WP_148044421.1 Added blaOXA-835 WP_148044422.1 Added blaOXA-836 WP_148044423.1 Added blaPAU-1 WP_148044424.1 Added blaPDC-196 WP_148044425.1 Added blaPDC-334 WP_148044426.1 Added blaPDC-335 WP_148044427.1 Added blaPDC-336 WP_148044428.1 Added blaPDC-337 WP_148044429.1 Added blaPDC-338 WP_148044430.1 Added blaPDC-339 WP_148044431.1 Added blaPDC-340 WP_148044432.1 Added blaPDC-341 WP_148044433.1 Added blaPDC-342 WP_148044434.1 Added blaPDC-343 WP_148044435.1 Added blaPDC-344 WP_148044436.1 Added blaPDC-345 WP_148044437.1 Added blaPDC-346 WP_148044438.1 Added blaPDC-347 WP_148044439.1 Added blaPDC-348 WP_148044440.1 Added blaPDC-349 WP_148044441.1 Added blaPDC-350 WP_148044442.1 Added blaPDC-351 WP_148044443.1 Added blaPDC-352 WP_148044444.1 Added blaPDC-354 WP_148044445.1 Added blaPDC-355 WP_148044446.1 Added blaPDC-356 WP_148044447.1 Added blaPDC-357 WP_148044448.1 Added blaPDC-358 WP_148044449.1 Added blaPDC-359 WP_148044450.1 Added blaPDC-360 WP_148044451.1 Added blaPDC-362 WP_148044452.1 Added blaPDC-363 WP_148044453.1 Added blaPDC-365 WP_148044454.1 Added blaPDC-366 WP_148044455.1 Added blaPDC-368 WP_148044456.1 Added blaPDC-369 WP_148044457.1 Added blaPDC-370 WP_148044458.1 Added blaPDC-372 WP_148044459.1 Added blaPDC-373 WP_148044460.1 Added blaPDC-375 WP_148044461.1 Added blaPDC-376 WP_148044462.1 Added blaPDC-377 WP_148044463.1 Added blaPDC-378 WP_148044464.1 Added blaPDC-379 WP_148044465.1 Added blaPDC-380 WP_148044466.1 Added blaPDC-381 WP_148044467.1 Added blaPDC-382 WP_148044468.1 Added blaPDC-383 WP_148044469.1 Added blaPFM-1 WP_148044470.1 Added blaTEM-241 WP_148044472.1 Added blaTEM-242 WP_148044473.1 Added blaTEM-39 WP_148044474.1 Added blaVEB-22 WP_148044475.1 Added blaVIM-68 WP_148044476.1 Added mcr-1.22 WP_148044477.1 Added mcr-5.4 WP_148044478.1 Added blaOXA-837 WP_148281568.1 Added gyrA_H80P WP_001281243.1 Added gyrA_N57K WP_001281243.1 Added gyrA_S83F WP_001281243.1 Changes: faeG AAA24032.1 product_name F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG faeG AAA24035.1 product_name F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG faeG AAA24390.1 product_name F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG nccX AAA65102.1 subclass METAL -> merB AAA88369.1 class MECURY -> MERCURY subclass ORGANOMECURY -> ORGANOMERCURY merC AAC33908.1 class MECURY -> MERCURY subclass ORGANOMECURY -> ORGANOMERCURY faeG AAC34727.1 product_name F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG merB AAC38230.1 class MECURY -> MERCURY subclass ORGANOMECURY -> ORGANOMERCURY merC AAC38233.1 class MECURY -> MERCURY subclass ORGANOMECURY -> ORGANOMERCURY ipaH2 AAN43435.1 gene_family ipaH9.8 -> ipaH2 product_name T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2 mreA AAN68577.1 subclass METAL -> ipaH2 AAZ87985.1 gene_family ipaH9.8 -> ipaH2 product_name T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2 ipaH3 ABB62096.1 gene_family ipaH9.8 -> ipaH3 product_name T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH3 ipaH2 ABB62098.1 gene_family ipaH9.8 -> ipaH2 product_name T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2 ipaH2 ABB66229.1 gene_family ipaH9.8 -> ipaH2 product_name T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2 ipaH1 ABF02983.1 gene_family ipaH9.8 -> ipaH1 product_name T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH1/H6 ipaH2 ABF04028.1 gene_family ipaH9.8 -> ipaH2 product_name T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2 faeG ACB72721.1 product_name F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG ipaH2 ACD09076.1 gene_family ipaH9.8 -> ipaH2 product_name T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2 faeG AFH14350.1 product_name F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG merC BAA14138.2 class MECURY -> MERCURY subclass ORGANOMECURY -> ORGANOMERCURY merB BAA20338.2 class MECURY -> MERCURY subclass ORGANOMECURY -> ORGANOMERCURY merG BAA23166.1 class MECURY -> MERCURY merB BAB47641.1 class MECURY -> MERCURY subclass ORGANOMECURY -> ORGANOMERCURY merB CAC86907.1 class MECURY -> MERCURY subclass ORGANOMECURY -> ORGANOMERCURY faeG CAE82650.1 product_name F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG faeG CAE82653.1 product_name F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG faeG CAE82670.1 product_name F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG mphL WP_002047670.1 gene_family mph(B) -> mphL product_name Mph(B) family macrolide 2'-phosphotransferase -> macrolide 2'-phosphotransferase MphL poxtA WP_002415638.1 genbank_cds_start 1856 -> 57639 genbank_cds_stop 3484 -> 59267 genbank_nucleotide_accession MF095097.1 -> MH746818.1 mcr-3.22 WP_094308975.1 refseq_nucleotide_accession NG_060581.1 -> NG_060581.2 blaPDC-259 WP_109791193.1 genbank_nucleotide_accession MH243333.1 -> MH243333.2 refseq_nucleotide_accession NG_057591.1 -> NG_057591.2 blaPDC-265 WP_109791199.1 genbank_nucleotide_accession MH243339.1 -> MH243339.2 refseq_nucleotide_accession NG_057597.1 -> NG_057597.2 - HMM library Changes: Total: Added 6 Total: Prev. Release 603 Total: Removed 1 Total: This Release 608 HMM Removed: NF000274.2 PF04439 HMM Added: NF007456.1 PRK10026.1 HMM Added: NF033636.1 acid_shock_Asr HMM Added: NF033877.0 arsB_Sta_pI258 HMM Added: NF033895.1 blaCAM HMM Added: NF033929.1 blaAXC HMM Added: NF033933.0 fosA8 - Protein family changes: Total: Added 47 Total: Prev. Release 1454 Total: Removed 1 Total: This Release 1500 Family Removed: - ubiq_IpaH3 Family Added: - ACID Family Added: - CDF_efflux Family Added: - amvA Family Added: NF033877.0 arsB_pI258 Family Added: - arsB_pKW301 Family Added: - arsB_pYV Family Added: NF007456.1 arsC_gluta Family Added: - arsR Family Added: - arsR_K-12 Family Added: - arsR_R46 Family Added: - arsR_pI258 Family Added: - arsR_pKW301 Family Added: - arsR_pSX267 Family Added: - arsR_pYV Family Added: NF033636.1 asr Family Added: NF033929.1 blaAXC Family Added: NF033895.1 blaCAM Family Added: - blaPFM Family Added: - cif Family Added: - copC_Psyr Family Added: - dfrA29 Family Added: - efa1 Family Added: - erm(49) Family Added: - espK Family Added: - fieF Family Added: NF033933.0 fosA8 Family Added: - hlyA-alpha Family Added: - icr-Mo Family Added: - iha Family Added: - ipaH1 Family Added: - ipaH2 Family Added: - ipaH3 Family Added: - ipaH4 Family Added: - ipaH5 Family Added: - ipa_gen Family Added: - kdeA Family Added: - lmrC_abcf Family Added: - mphH Family Added: - mphK Family Added: - mphL Family Added: - mphM Family Added: - mphN Family Added: - pic_auto Family Added: - sab Family Added: - senB Family Added: - stb Family Added: - tet(56) Family Changed: NF000274.2 ant6_gen updated to - ant6_gen --------------------------------------------------------------------- Changes included in 2019-07-10.1 --------------------------------------------------------------------- New alleles and sequences were added, a few product names were made more specific as more phenotype information became available. Cleanup of the database caused some families and HMMs not used by AMRFinderPlus to be removed. - Protein changes: Total: Added 57 Total: Prev. Release 5757 Total: Removed 3 Total: This Release 5811 Protein Removed: WP_029728367.1 blaB BlaB_family_subclass_B1_metallo-beta-lactamase Protein Removed: WP_063842622.1 blaB BlaB_family_subclass_B1_metallo-beta-lactamase Protein Removed: WP_063842629.1 blaGOB GOB_family_subclass_B3_metallo-beta-lactamase Protein Added: AAA21095.1 arsB_R773 arsenite_efflux_transporter_membrane_subunit_ArsB Protein Added: ABQ18953.1 emrD3 multidrug_efflux_MFS_transporter_EmrD-3 Protein Added: WP_000850833.1 emrD3 multidrug_efflux_MFS_transporter_EmrD-3 Protein Added: WP_010446567.1 tet(B) tetracycline_efflux_MFS_transporter_Tet(B) Protein Added: WP_039902635.1 blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-646 Protein Added: WP_063116263.1 arsB_R773 arsenite_efflux_transporter_membrane_subunit_ArsB Protein Added: WP_063844329.1 dfrA12 trimethoprim-resistant_dihydrofolate_reductase_DfrA12 Protein Added: WP_063856066.1 tet(B) tetracycline_efflux_MFS_transporter_Tet(B) Protein Added: WP_063856068.1 tet(B) tetracycline_efflux_MFS_transporter_Tet(B) Protein Added: WP_070342370.1 dfrA7 trimethoprim-resistant_dihydrofolate_reductase_DfrA7 Protein Added: WP_071593205.1 aadA1bt ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1bt Protein Added: WP_071593208.1 aadA1bt ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1bt Protein Added: WP_086264536.1 blaOXA-213_like OXA-213_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-832 Protein Added: WP_094323230.1 mcr-2 phosphoethanolamine--lipid_A_transferase_MCR-2.3 Protein Added: WP_110174956.1 blaTEM class_A_beta-lactamase_TEM-235 Protein Added: WP_125052736.1 blaOXA-51_like OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-834 Protein Added: WP_129336087.1 mcr-1 phosphoethanolamine--lipid_A_transferase_MCR-1.19 Protein Added: WP_135350920.1 blaGES class_A_beta-lactamase_GES-41 Protein Added: WP_140423191.1 aac(6')-Ib AAC(6')-Ib_family_aminoglycoside_6'-N-acetyltransferase Protein Added: WP_140423278.1 aadA1 ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1 Protein Added: WP_140423279.1 aadA2 ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2 Protein Added: WP_140423280.1 aadA2 ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2 Protein Added: WP_140423281.1 aadA2 ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2 Protein Added: WP_140423282.1 aadA5 ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA5 Protein Added: WP_140423283.1 dfrA1 trimethoprim-resistant_dihydrofolate_reductase_DfrA1 Protein Added: WP_140423284.1 dfrA12 trimethoprim-resistant_dihydrofolate_reductase_DfrA12 Protein Added: WP_140423285.1 dfrA17 trimethoprim-resistant_dihydrofolate_reductase_DfrA17 Protein Added: WP_140423286.1 dfrA17 trimethoprim-resistant_dihydrofolate_reductase_DfrA17 Protein Added: WP_140423287.1 dfrA17 trimethoprim-resistant_dihydrofolate_reductase_DfrA17 Protein Added: WP_140423305.1 blaADC class_C_beta-lactamase_ADC-195 Protein Added: WP_140423306.1 blaB subclass_B1_metallo-beta-lactamase_BlaB-15 Protein Added: WP_140423307.1 blaCMY class_C_beta-lactamase_CMY-164 Protein Added: WP_140423308.1 blaFRI carbapenem-hydrolyzing_class_A_beta-lactamase_FRI-8 Protein Added: WP_140423309.1 blaFRI carbapenem-hydrolyzing_class_A_beta-lactamase_FRI-9 Protein Added: WP_140423310.1 blaIMI carbapenem-hydrolyzing_class_A_beta-lactamase_IMI-19 Protein Added: WP_140423311.1 blaKPC carbapenem-hydrolyzing_class_A_beta-lactamase_KPC-44 Protein Added: WP_140423312.1 blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-643 Protein Added: WP_140423313.1 blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-644 Protein Added: WP_140423314.1 blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-645 Protein Added: WP_140423315.1 blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-647 Protein Added: WP_140423316.1 blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-648 Protein Added: WP_140423317.1 blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-650 Protein Added: WP_140423318.1 blaOXA-143_like OXA-143_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-825 Protein Added: WP_140423319.1 blaOXA-213_like OXA-213_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-826 Protein Added: WP_140423320.1 blaOXA-10_like OXA-10_family_class_D_beta-lactamase_OXA-827 Protein Added: WP_140423321.1 blaOXA-51_like OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-828 Protein Added: WP_140423322.1 blaOXA-51_like OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-829 Protein Added: WP_140423323.1 blaOXA-51_like OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-831 Protein Added: WP_140423324.1 blaOXA-48_like OXA-48_family_class_D_beta-lactamase_OXA-833 Protein Added: WP_140423325.1 blaPDC class_C_beta-lactamase_PDC-333 Protein Added: WP_140423326.1 blaPOM subclass_B3_metallo-beta-lactamase_POM-2 Protein Added: WP_140423327.1 blaVIM subclass_B1_metallo-beta-lactamase_VIM-64 Protein Added: WP_140423328.1 blaVIM subclass_B1_metallo-beta-lactamase_VIM-65 Protein Added: WP_140423329.1 mcr-1 phosphoethanolamine--lipid_A_transferase_MCR-1.20 Protein Added: WP_140423330.1 mcr-1 phosphoethanolamine--lipid_A_transferase_MCR-1.21 Protein Added: WP_140423331.1 mcr-3 phosphoethanolamine--lipid_A_transferase_MCR-3.26 Protein Added: WP_140423332.1 mcr-3 phosphoethanolamine--lipid_A_transferase_MCR-3.30 Protein Modified: ACM67153.1 lamda-2 intimin_type_lambda updated to ACM67153.1 lambda-2 intimin_type_lambda Protein Modified: WP_001100753.1 blaPER class_A_extended-spectrum_beta-lactamase_PER-1 updated to WP_001100753.1 blaPER inhibitor-resistant_class_A_extended-spectrum_beta-lactamase_PER-1 Protein Modified: WP_002317273.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_002317273.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR Protein Modified: WP_002368697.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_002368697.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR Protein Modified: WP_032489743.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_032489743.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR Protein Modified: WP_063856719.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856719.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR Protein Modified: WP_063856723.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856723.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR Protein Modified: WP_063856729.1 vanR-O VanO-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856729.1 vanR-O VanO-type_vancomycin_resistance_response_regulator_transcription_factor_VanR Protein Modified: WP_063860636.1 blaKPC carbapenem-hydrolyzing_class_A_beta-lactamase_KPC-14 updated to WP_063860636.1 blaKPC inhibitor-resistant_class_A_extended-spectrum_beta-lactamase_KPC-14 - AMR HMM library Changes: Total: Added 5 Total: Prev. Release 610 Total: Removed 12 Total: This Release 603 HMM Removed: NF000252.1 MexX HMM Removed: NF000282.2 RND_permease_1 HMM Removed: NF000314.1 adeB HMM Removed: NF000315.1 adeC-adeK-oprM HMM Removed: NF007842.1 PRK10555.1 HMM Removed: NF011706.2 PRK15127.1 HMM Removed: NF028537.1 P_eth_NH2_trans HMM Removed: NF033086.2 penta_rpt_Qnr HMM Removed: NF033134.0 cmlA_floR HMM Removed: NF033143.1 efflux_OM_AdeK HMM Removed: NF033643.1 EspJ_gen HMM Removed: NF033651.1 cyto_nec_fctrs HMM Added: NF000478.2 linco_LnuE HMM Added: NF012180.1 tet_MFS_43 HMM Added: NF033866.1 blaCDD HMM Added: NF033867.1 blaPAU HMM Added: NF033868.0 trim_DfrA36 - Protein family changes: Total: Added 11 Total: Prev. Release 1449 Total: Removed 6 Total: This Release 1454 Family Removed: NF011706.2 acrB Family Removed: NF007842.1 acrD Family Removed: NF000314.1 adeB/adeJ Family Removed: NF033143.1 adeK Family Removed: - lamda Family Removed: - lamda-2 Family Added: - aadA1bt Family Added: - arsB Family Added: - arsB_R773 Family Added: NF033866.1 blaCDD Family Added: NF033867.1 blaPAU Family Added: NF033868.0 dfrA36 Family Added: - emrD3 Family Added: - lambda Family Added: - lambda-2 Family Added: NF000478.2 lnu(E) Family Added: NF012180.1 tet(43) Family Changed: NF030466.1 MerP_Gneg updated to TIGR02052.1 MerP_Gneg Family Changed: NF030467.1 merA updated to TIGR02053.1 merA --------------------------------------------------------------------- Changes included in 2019-06-18.1 --------------------------------------------------------------------- This the first alpha release of the AMRFinderPlus database. For this and all following releases there is a distinction between "core" proteins which correspond to the genes that would previously have been reported by AMRFinder and "plus" proteins that are new genes and classes of genes. The "core" designation is given to proteins where we believe their presence is likely to have an important effect on antimicrobial resistance. * Screen for select point mutations for antibiotic resistance from Salmonella, E. coli, and Campylobacter * Protein mutations in: 50S_L22 protein, acrB, acrR, basR, cmeR, cyaA, fabG, fabI, folP, gyrA, gyrB, lon, marR, murA, nfsA, ompF, parC, parE, pmrA, pmrB, ptsI, ramR, rpoB, rpsL, soxR, soxS, tufA, uhpA, uhpT * Nucleotide mutations in 16S and 23S rRNA * Included point mutations are listed in the reference gene database (https://www.ncbi.nlm.nih.gov/pathogens/isolates#/refgene/) * New "Plus" genes * virulence factors * biocide resistance * metal resistance * heat resistance * acid resistance * Combined and integrated results from nucleotide and protein searches File formats have changed significantly. See https://github.com/evolarjun/amr/wiki for details. Since release 2019-04-29.1 only one change has been made to the core AMR proteins. Qac's are now categorized under Type STRESS and Subtype BIOCIDE. - Protein changes: Prev. Release: 4942 This Release: 5718 Added: 776 Modified: 0 Protein Added: ABF69110.1 eae intimin type beta Protein Added: ABF69117.1 eae intimin type epsilon Protein Added: ABF69121.1 eae intimin type epsilon Protein Added: ABF69122.1 eae intimin type alpha Protein Added: KYU89760.1 subB subtilase AB5 cytotoxin subunit B Protein Added: AAG16664.1 perA BFP system transcriptional regulator PerA Protein Added: AAG16667.1 perA BFP system transcriptional regulator PerA Protein Added: AAG16676.1 perA BFP system transcriptional regulator PerA Protein Added: AAB09625.1 arsD arsenite efflux transporter metallochaperone ArsD Protein Added: AAB09626.1 arsA arsenite efflux transporter ATPase subunit ArsA Protein Added: CAJ76690.1 stx1Aa Shiga toxin Stx1a subunit A Protein Added: CAJ76692.1 stx1Aa Shiga toxin Stx1a subunit A Protein Added: AAA98291.1 terC tellurium resistance membrane protein TerC Protein Added: AAA98293.1 terE tellurium resistance cAMP binding protein TerE Protein Added: AAG27731.1 norM sodium-coupled multidrug efflux MATE transporter NorM Protein Added: ABF02983.1 ipaH9.8 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 Protein Added: ABF04028.1 ipaH9.8 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 Protein Added: BAE98279.1 bfpA bundle-forming pilus major subunit BfpA Protein Added: BAE98281.1 bfpA bundle-forming pilus major subunit BfpA Protein Added: CAC14596.1 smeF multidrug efflux RND transporter outer membrane subunit SmeF Protein Added: AAA83973.1 merR1 mercury resistance transcriptional regulator MerR1 Protein Added: AAA83975.1 merT mercuric transport protein MerT Protein Added: AAA98292.1 terD tellurium resistance membrane protein TerD Protein Added: AAG34504.1 perA BFP system transcriptional regulator PerA Protein Added: APX31172.1 yfdX1 heat resistance protein YfdX1 Protein Added: APX31174.1 hdeD-GI heat resistance membrane protein HdeD-GI Protein Added: APX31176.1 trxLHR heat resistance system thioredoxin Trx-GI Protein Added: APX31177.1 kefB-GI heat resistance system K+/H+ antiporter KefB-GI Protein Added: APX31178.1 psi-GI heat resistance protein PsiE-GI Protein Added: AAA85087.1 f17a F17A fimbrial adhesin Protein Added: AAA85196.1 cnf1 cytotoxic necrotizing factor CNF1 Protein Added: AAG37043.1 espC serine protease autotransporter toxin EspC Protein Added: ABI93207.1 fedF F18 fimbrial adhesin subunit FedF Protein Added: BAF33872.1 capU putative hexosyltransferase CapU Protein Added: BAF33878.1 aggR aggregative adherence transcriptional regulator AggR Protein Added: BAF33885.1 sepA serine protease autotransporter toxin SepA Protein Added: BAF33888.1 agg4D aggregative adherence fimbria 4 chaperone Agg4D/HdaD Protein Added: BAF33891.1 agg4A aggregative adherence fimbria 4 major subunit Agg4A/HdaA Protein Added: BAF33901.1 aatA dispersin export ABC transporter outer membrane protein AatA Protein Added: BAF34018.1 aap dispersin Aap Protein Added: ABJ00546.1 iss increased serum survival lipoprotein Iss Protein Added: ABJ02430.1 ireA TonB-dependent siderophore receptor IreA Protein Added: OPH66324.1 lpfA1 long polar fimbria major subunit LpfA1 Protein Added: ABJ90288.1 fedF F18 fimbrial adhesin subunit FedF Protein Added: AAA86846.1 terZ tellurium resistance-associated protein TerZ Protein Added: ABC67318.2 stx2Aa Shiga toxin Stx2a subunit A Protein Added: AAG40758.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAA88371.1 merE broad-spectrum mercury transporter MerE Protein Added: AAG42788.1 perA BFP system transcriptional regulator PerA Protein Added: ASF80766.1 yfdX2 heat resistance protein YfdX2 Protein Added: ASF80771.1 shsP small heat shock protein sHSP20-GI Protein Added: CAM11313.1 nleA type III secretion system effector NleA Protein Added: CAM11314.1 nleA type III secretion system effector NleA Protein Added: CAM11315.1 nleA type III secretion system effector NleA Protein Added: CAM11317.1 nleA type III secretion system effector NleA Protein Added: CAM11321.1 nleA type III secretion system effector NleA Protein Added: CAM11323.1 nleA type III secretion system effector NleA Protein Added: CAM11324.1 nleA type III secretion system effector NleA Protein Added: CAM11325.1 nleA type III secretion system effector NleA Protein Added: AAA92618.1 f17a F17A fimbrial adhesin Protein Added: AAA92621.1 f17g F17G fimbrial adhesin Protein Added: AAA93060.1 arsD arsenite efflux transporter metallochaperone ArsD Protein Added: AAG53662.1 perA BFP system transcriptional regulator PerA Protein Added: BAF45432.1 tccP Tir-cytoskeleton coupling protein TccP Protein Added: BAF45437.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF45439.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF45440.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF45447.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF45451.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF45459.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: ABM90581.1 perA BFP system transcriptional regulator PerA Protein Added: ABM90583.1 perA BFP system transcriptional regulator PerA Protein Added: ABM90587.1 perA BFP system transcriptional regulator PerA Protein Added: ABM90589.1 perA BFP system transcriptional regulator PerA Protein Added: ABM90597.1 perA BFP system transcriptional regulator PerA Protein Added: ABM90605.1 perA BFP system transcriptional regulator PerA Protein Added: ABM90615.1 perA BFP system transcriptional regulator PerA Protein Added: AAC46147.1 yfeA iron/manganese ABC transporter substrate-binding protein YfeA Protein Added: AAC46148.1 yfeB iron/manganese ABC transporter ATP-binding protein YfeB Protein Added: AAC46150.1 yfeD iron/manganese ABC transporter permease subunit YfeD Protein Added: ATE69525.1 acr3 arsenite efflux transporter Acr3 Protein Added: AAG55141.1 nleC type III secretion system effector zinc metalloprotease NleC Protein Added: AAG56990.1 espJ type III secretion system effector ADP-ribosyltransferase EspJ Protein Added: AAG58695.1 lpfA1 long polar fimbria major subunit LpfA1 Protein Added: AAG58814.1 espF type III secretion system LEE effector EspF Protein Added: AAG58818.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: AAG58825.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAK15050.1 ttgR efflux transport transcriptional regulator TtgR Protein Added: AAK16940.1 nleA type III secretion system effector NleA Protein Added: AAK17180.1 nfaE Dr family non-fimbrial adhesin I chaperone NfaE Protein Added: AAK18385.1 sepA serine protease autotransporter toxin SepA Protein Added: AAK18444.1 ipaD type III secretion system needle tip complex protein IpaD Protein Added: BAB37280.1 nleB type III secretion system effector arginine glycosyltransferase NleB Protein Added: BAB38093.1 lpfA2 long polar fimbria major subunit LpfA2 Protein Added: AAC44736.1 terW tellurium resistance protein TerW Protein Added: AVL28824.1 aar AggR-activated transcriptional regulator Aar Protein Added: SPD96882.1 silS copper/silver sensor histidine kinase SilS Protein Added: SPD96883.1 silR copper/silver response regulator transcription factor SilR Protein Added: SPD96884.1 silC Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC Protein Added: CAA57177.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: CAA57175.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: CAA57173.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: CAA57171.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: BAB43874.1 cadD cadmium resistance transporter CadD Protein Added: AAK48830.1 cadR cadmium resistance transcriptional regulator CadR Protein Added: BAF52034.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52035.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52033.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52358.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52360.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52362.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52363.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52364.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52365.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52366.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52367.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52370.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52374.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52377.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAF52548.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: BAF52549.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: BAB47641.1 merB organomercurial lyase MerB Protein Added: AAK56853.1 chrR class I chromate reductase ChrR Protein Added: CAC39286.1 espI serine protease autotransporter EspI Protein Added: AAA83977.1 merA mercury(II) reductase Protein Added: AAA23405.1 fasA F6 fimbrial major subunit FasA Protein Added: AAA23421.1 fim41a fimbrial adhesin F41 protein Fim41a Protein Added: AAK66972.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: AAC41416.1 cfaC CFA/I pilus usher protein CfaC Protein Added: CAB54534.2 mchB microcin H47 Protein Added: AAK69562.1 srpS solvent efflux transporter transcriptional repressor SrpS Protein Added: AAA23734.1 fedA F18 fimbrial major subunit FedA Protein Added: ABQ02454.1 eae intimin type rho Protein Added: AAA24032.1 faeG F4 fimbrial adhesin subunit FaeG Protein Added: AAA24035.1 faeG F4 fimbrial adhesin subunit FaeG Protein Added: AAA24390.1 faeG F4 fimbrial adhesin subunit FaeG Protein Added: AXV27948.1 agg3C aggregative adherence fimbria 3 usher protein Agg3C Protein Added: AAA19189.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: AAA19190.1 stx2Be Shiga toxin Stx2e subunit B Protein Added: AAA24632.1 stx2Af Shiga toxin Stx2f subunit A Protein Added: AAA24633.1 stx2Bf Shiga toxin Stx2f subunit B Protein Added: AAA71893.1 stx1Aa Shiga toxin Stx1a subunit A Protein Added: AAA71894.1 stx1Ba Shiga toxin Stx1a subunit B Protein Added: AAA24653.1 sta1 heat-stable enterotoxin ST-I group a Protein Added: ABR09925.1 stx2Ba Shiga toxin Stx2a subunit B Protein Added: ABR09934.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: ABR09935.1 stx2Bc Shiga toxin Stx2c subunit B Protein Added: ABR09936.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: ABR09937.1 stx2Bd Shiga toxin Stx2d subunit B Protein Added: ABR09945.1 stx2Ba Shiga toxin Stx2a subunit B Protein Added: ABR09961.1 stx2Ba Shiga toxin Stx2a subunit B Protein Added: ABR09963.1 stx2Ba Shiga toxin Stx2a subunit B Protein Added: ABR10024.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: CAA30714.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: CAA30715.1 stx2Ba Shiga toxin Stx2a subunit B Protein Added: AAB59075.1 merT mercuric transport protein MerT Protein Added: AAA88369.1 merB organomercurial lyase MerB Protein Added: AAA88370.1 merD mercury resistance co-regulator MerD Protein Added: AAA98222.1 merT mercuric transport protein MerT Protein Added: AAA98223.1 merP mercury resistance system periplasmic binding protein MerP Protein Added: AAA25638.1 arsC thioredoxin-dependent arsenate reductase Protein Added: AAA88432.1 chrA chromate resistance efflux protein ChrA Protein Added: AAA25803.1 copR heavy metal response regulator transcription factor CopR Protein Added: AAA25804.1 copS copper resistance membrane spanning protein CopS Protein Added: AAA25806.1 copA laccase-like oxidase CopA Protein Added: AAA25807.1 copB copper-binding protein CopB Protein Added: CAC48396.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: CAC48398.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: AAA21094.1 arsA arsenite efflux transporter ATPase subunit ArsA Protein Added: BAB62897.1 cofA type IV pilus CFA/III major pilin Protein Added: BAB62907.1 cofA type IV pilus CFA/III major pilin Protein Added: CAA63849.1 ehxA enterohemolysin Protein Added: AAA26402.1 klaB tellurium resistance system protein klaB Protein Added: AAA26403.1 klaC tellurium resistance system protein klaC Protein Added: AAK97136.1 cfaC CFA/I pilus usher protein CfaC Protein Added: AAK99679.1 pmrA multidrug efflux MFS transporter PmrA Protein Added: CAC69248.1 merR mercury resistance transcriptional regulator MerR Protein Added: CAC69249.1 merT mercuric transport protein MerT Protein Added: CAC69250.1 merP mercury resistance system periplasmic binding protein MerP Protein Added: CAC69251.1 merA mercury(II) reductase Protein Added: BAB64566.1 bexA multidrug efflux MATE transporter BexA Protein Added: AAA27589.1 arsC thioredoxin-dependent arsenate reductase Protein Added: ABU55302.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: BAF76383.1 ttgA toluene efflux RND transporter periplasmic adaptor subunit TtgA Protein Added: BAF76384.1 ttgB multidrug efflux RND transporter permease subunit TtgB Protein Added: ABV01314.1 ltcA heat-labile enterotoxin LT subunit A Protein Added: BAF79679.1 smdA multidrug efflux ABC transporter permease/ATP-binding subunit SmdA Protein Added: BAF79680.1 smdB multidrug efflux ABC transporter permease/ATP-binding subunit SmdB Protein Added: ABV16438.1 eatA serine protease autotransporter toxin EatA Protein Added: BAB68369.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: BAB68370.1 stx2Bc Shiga toxin Stx2c subunit B Protein Added: BAF80121.1 ssmE multidrug efflux SMR transporter SsmE Protein Added: AAL06376.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAL06381.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: AAL06387.1 espF type III secretion system LEE effector EspF Protein Added: AAC23256.1 hmrM sodium-coupled multidrug efflux MATE transporter HmrM Protein Added: ABQ02442.1 ehxA enterohemolysin Protein Added: ABQ02443.1 ehxA enterohemolysin Protein Added: ABQ02445.1 ehxA enterohemolysin Protein Added: ABQ02447.1 ehxA enterohemolysin Protein Added: ABQ02448.1 ehxA enterohemolysin Protein Added: AAL08400.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: BAF92845.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAL14441.1 adeC multidrug efflux RND transporter AdeABC outer membrane channel subunit AdeC Protein Added: CAP17609.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: CAP17610.1 stx2Be Shiga toxin Stx2e subunit B Protein Added: AAL18821.1 epeA serine protease autotransporter EpeA Protein Added: AAL19305.1 mdsB multidrug efflux RND transporter permease subunit MdsB Protein Added: AAL19306.1 mdsA multidrug efflux RND transporter periplasmic adaptor subunit MdsA Protein Added: AAL19307.1 golT gold/copper-translocating P-type ATPase GolT Protein Added: AAL19308.1 golS Au(I) sensor transcriptional regulator GolS Protein Added: BAF96525.1 espJ type III secretion system effector ADP-ribosyltransferase EspJ Protein Added: BAF96538.1 nleB2 type III secretion system effector arginine glycosyltransferase NleB2 Protein Added: BAF96541.1 nleA type III secretion system effector NleA Protein Added: BAA18405.1 acr3 arsenite efflux transporter Acr3 Protein Added: BAA18407.1 arsC thioredoxin-dependent arsenate reductase Protein Added: AAL26283.1 saa autoagglutinating adhesin Saa Protein Added: CAA65654.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: AAC45964.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: AAC45965.1 stx2Be Shiga toxin Stx2e subunit B Protein Added: ACA34793.1 tsh temperature-sensitive protease autotransporter hemagglutinin Tsh Protein Added: BAG11995.1 tccP Tir-cytoskeleton coupling protein TccP Protein Added: BAG11997.1 tccP Tir-cytoskeleton coupling protein TccP Protein Added: BAG12001.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: ACB16424.1 lpfA long polar fimbria major subunit LpfA-O113 Protein Added: ACB16655.1 eilA HilA family transcriptional regulator EilA Protein Added: ACB17037.1 air inverse autotransporter adhesin EaeX/Air Protein Added: CAA70196.1 merT mercuric transport protein MerT Protein Added: ACB72721.1 faeG F4 fimbrial adhesin subunit FaeG Protein Added: AAC44731.1 espC serine protease autotransporter toxin EspC Protein Added: AAC74250.1 ymgB biofilm/acid-resistance regulator AriR Protein Added: AAC76298.1 acrF multidrug efflux RND transporter permease subunit AcrF Protein Added: AAC77293.1 mdtM multidrug efflux MFS transporter MdtM Protein Added: AAL57565.1 nleB type III secretion system effector arginine glycosyltransferase NleB Protein Added: BAB82994.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: BAB82996.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: BAB82998.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: BAB83000.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: BAB83002.1 stx2Ag Shiga toxin Stx2g subunit A Protein Added: BAB83003.1 stx2Bg Shiga toxin Stx2g subunit B Protein Added: BAB83005.1 stx2Bb Shiga toxin Stx2b subunit B Protein Added: BAB83007.1 stx2Bb Shiga toxin Stx2b subunit B Protein Added: BAB83020.1 stx2Ag Shiga toxin Stx2g subunit A Protein Added: BAB83022.1 stx1Ac Shiga toxin Stx1c subunit A Protein Added: BAB83023.1 stx1Bc Shiga toxin Stx1c subunit B Protein Added: BAB83024.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: AAL72309.1 sepA serine protease autotransporter toxin SepA Protein Added: AAL72350.1 ipaD type III secretion system needle tip complex protein IpaD Protein Added: AAL05407.1 tcrB copper-translocating P-type ATPase TcrB Protein Added: ACD06066.1 capU putative hexosyltransferase CapU Protein Added: ACD06132.1 ipaD type III secretion system needle tip complex protein IpaD Protein Added: ACD07996.1 ipaH3 T3SS effector E3 ubiquitin-protein ligase IpaH3 Protein Added: ACD09076.1 ipaH9.8 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 Protein Added: BAA11821.1 chrR class I chromate reductase ChrR Protein Added: CAQ45062.1 emrC multidrug efflux transporter outer membrane subunit EmrC Protein Added: CAQ45063.1 emrA multidrug efflux MFS transporter periplasmic adaptor subunit EmrA Protein Added: CAQ45064.1 emrB multidrug efflux MFS transporter permease subunit EmrB Protein Added: ACF05260.1 agg4A aggregative adherence fimbria 4 major subunit Agg4A/HdaA Protein Added: ACF30254.1 mtrR multidrug efflux system transcriptional repressor MtrR Protein Added: ACF30256.1 mtrF AbgT family antimetabolite efflux transporter MtrF Protein Added: BAG66379.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAG66729.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: BAG66736.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: ACG59623.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: ACG59674.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: ACG59676.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: ACG59681.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: ACG59730.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: ACG59732.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: ACG59737.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: ACG76368.1 arsP organoarsenical efflux permease ArsP Protein Added: ACI12150.1 terB tellurium resistance membrane protein TerB Protein Added: BAG76115.1 iss increased serum survival lipoprotein Iss Protein Added: AAA98099.1 stx1Aa Shiga toxin Stx1a subunit A Protein Added: CAS08589.1 nleB2 type III secretion system effector arginine glycosyltransferase NleB2 Protein Added: CAS08990.1 nleA type III secretion system effector NleA Protein Added: CAS10463.1 espC serine protease autotransporter toxin EspC Protein Added: CAS06720.1 eae intimin type gamma Protein Added: CAS06721.1 eae intimin type alpha Protein Added: CAS06723.1 eae intimin type alpha Protein Added: BAA20334.1 merR mercury resistance transcriptional regulator MerR Protein Added: BAA20336.1 merP mercury resistance system periplasmic binding protein MerP Protein Added: BAA20337.1 merA mercury(II) reductase Protein Added: AAM70045.1 stx2Aa Shiga toxin Stx2a subunit A Protein Added: CAQ87187.1 iroN siderophore salmochelin receptor IroN Protein Added: CAV00478.1 lpfA long polar fimbria major subunit LpfA Protein Added: CAV00812.1 lpfA long polar fimbria major subunit LpfA-O113 Protein Added: CAV02025.1 capU putative hexosyltransferase CapU Protein Added: CAQ90194.1 iss increased serum survival lipoprotein Iss Protein Added: CAU95796.1 aatA dispersin export ABC transporter outer membrane protein AatA Protein Added: CAU95824.1 agg3D aggregative adherence fimbria 3 chaperone Agg3D Protein Added: CAQ97644.1 iss increased serum survival lipoprotein Iss Protein Added: CAR01635.1 vactox vacuolating autotransporter toxin Vat Protein Added: CAR09703.2 ireA TonB-dependent siderophore receptor IreA Protein Added: CAR12622.1 iss increased serum survival lipoprotein Iss Protein Added: CAR15326.1 air inverse autotransporter adhesin EaeX/Air Protein Added: CAW30811.1 nfaE Dr family non-fimbrial adhesin I chaperone NfaE Protein Added: CAW30815.1 nfaE Dr family non-fimbrial adhesin I chaperone NfaE Protein Added: ACL13561.1 copR heavy metal response regulator transcription factor CopR Protein Added: ACL13562.1 copS copper resistance membrane spanning protein CopS Protein Added: ACL51961.1 ehxA enterohemolysin Protein Added: ACL51990.1 toxB toxin B Protein Added: AAM88296.1 agg3C aggregative adherence fimbria 3 usher protein Agg3C Protein Added: AAM88297.1 agg3B aggregative adherence fimbria 3 minor subunit Agg3B Protein Added: AAM88298.1 agg3A aggregative adherence fimbria 3 major subunit Agg3A Protein Added: AAM88299.1 astA heat-stable enterotoxin EAST1 Protein Added: AAM88302.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: BAA14138.2 merC organomercurial transporter MerC Protein Added: AAM88668.1 cueA copper resistance metal-translocating P1-type ATPase CueA Protein Added: AAM90978.1 stx2Ba Shiga toxin Stx2a subunit B Protein Added: CAX18553.1 nleB type III secretion system effector arginine glycosyltransferase NleB Protein Added: CAX18626.1 nleB type III secretion system effector arginine glycosyltransferase NleB Protein Added: CAX18635.1 espF type III secretion system LEE effector EspF Protein Added: CAX18641.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: CAX18646.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: CAX18721.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: CAX18726.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: ACM67143.1 eae intimin type alpha Protein Added: ACM67145.1 eae intimin type iota Protein Added: ACM67146.1 eae intimin type alpha Protein Added: ACM67148.1 eae intimin type gamma Protein Added: ACM67149.1 eae intimin type gamma Protein Added: ACM67152.1 eae intimin type beta Protein Added: ACM67153.1 eae intimin type lambda Protein Added: ACM67154.1 eae intimin type gamma Protein Added: ACM67155.1 eae intimin type epsilon Protein Added: ACM67156.1 eae intimin type epsilon Protein Added: ACM67157.1 eae intimin type beta Protein Added: ACM67158.1 eae intimin type epsilon Protein Added: ACM67160.1 eae intimin type beta Protein Added: ACM67161.1 eae intimin type beta Protein Added: ACM67162.1 eae intimin type gamma Protein Added: ACM67163.1 eae intimin type rho Protein Added: ACM67164.1 eae intimin type gamma Protein Added: ACM67165.1 eae intimin type gamma Protein Added: ACM67166.1 eae intimin type gamma Protein Added: ACM67167.1 eae intimin type epsilon Protein Added: ACM67168.1 eae intimin type alpha Protein Added: ACM67169.1 eae intimin type gamma Protein Added: ACM67172.1 eae intimin type epsilon Protein Added: ACM67177.1 eae intimin type gamma Protein Added: ACM67178.1 eae intimin type epsilon Protein Added: BAH24012.1 toxB toxin B Protein Added: CAB14520.2 acr3 arsenite efflux transporter Acr3 Protein Added: ACO06752.1 emhB efflux RND transporter permease subunit EmhB Protein Added: AAN03785.1 cnf1 cytotoxic necrotizing factor CNF1 Protein Added: AAN03786.1 cnf1 cytotoxic necrotizing factor CNF1 Protein Added: AAN04250.1 dpsA non-specific DNA-binding protein DpsA Protein Added: BAC10987.1 stx1Ac Shiga toxin Stx1c subunit A Protein Added: BAC10988.1 stx1Bc Shiga toxin Stx1c subunit B Protein Added: BAC10992.1 stx1Bc Shiga toxin Stx1c subunit B Protein Added: CAY54182.1 bfpA bundle-forming pilus major subunit BfpA Protein Added: AAN29240.1 bepD multidrug efflux RND transporter periplasmic adaptor subunit BepD Protein Added: AAN29241.1 bepE multidrug efflux RND transporter permease subunit BepE Protein Added: AAN29871.1 bepC multidrug efflux RND transporter outer membrane subunit BepC Protein Added: AAN33534.1 bepG multidrug efflux RND transporter permease subunit BepG Protein Added: AAN33535.1 bepF multidrug efflux RND transporter periplasmic adaptor subunit BepF Protein Added: CAD48850.1 cdtB cytolethal distending toxin type III/V nuclease subunit CdtB Protein Added: CAC86907.1 merB organomercurial lyase MerB Protein Added: BAH65949.1 iroN siderophore salmochelin receptor IroN Protein Added: BAH72965.1 cdtB cytolethal distending toxin type II nuclease subunit CdtB Protein Added: AAN42986.1 ipaH3 T3SS effector E3 ubiquitin-protein ligase IpaH3 Protein Added: AAN43435.1 ipaH9.8 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 Protein Added: AAN44449.1 sigA serine protease autotransporter toxin SigA Protein Added: CAQ68302.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: ACS88189.1 ipaD type III secretion system needle tip complex protein IpaD Protein Added: AAC45719.1 f17a F17A fimbrial adhesin Protein Added: AAC45722.1 f17g F17G fimbrial adhesin Protein Added: AAN68576.1 mrdH Ni(II)/Co(II) efflux transporter permease subunit MrdH Protein Added: AAN68577.1 mreA metal-sensing transcriptional repressor MreA Protein Added: ACT33468.1 f17a F17A fimbrial adhesin Protein Added: ACT33471.1 f17g F17G fimbrial adhesin Protein Added: ACT72391.1 tccP Tir-cytoskeleton coupling protein TccP Protein Added: CAR47993.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: CAR48009.1 nleB type III secretion system effector arginine glycosyltransferase NleB Protein Added: BAH86759.1 stx2Af Shiga toxin Stx2f subunit A Protein Added: BAH86760.1 stx2Bf Shiga toxin Stx2f subunit B Protein Added: BAA20338.2 merB organomercurial lyase MerB Protein Added: ACU32684.1 stx2Aa Shiga toxin Stx2a subunit A Protein Added: ACU65296.1 merA mercury(II) reductase Protein Added: CAX45702.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: CAX45706.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: CAX45714.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: CAX45718.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: CAX45737.1 stx2Bd Shiga toxin Stx2d subunit B Protein Added: CAX45739.1 stx2Ba Shiga toxin Stx2a subunit B Protein Added: CAX45746.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: CAX51714.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: AAB82330.1 aafA aggregative adherence fimbria II major subunit AafA Protein Added: BAI25473.1 nleC type III secretion system effector zinc metalloprotease NleC Protein Added: BAI31154.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: BAI32292.1 nleB type III secretion system effector arginine glycosyltransferase NleB Protein Added: BAI32327.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: BAI32516.1 espI serine protease autotransporter EspI Protein Added: BAI33940.1 etpD variant type II secretion system secretin EtpD Protein Added: BAI36256.1 nleC type III secretion system effector zinc metalloprotease NleC Protein Added: BAI36790.1 nleA type III secretion system effector NleA Protein Added: BAI37513.1 nleB type III secretion system effector arginine glycosyltransferase NleB Protein Added: BAI37519.1 espF type III secretion system LEE effector EspF Protein Added: BAI37525.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: BAA23166.1 merG phenylmercury resistance protein MerG Protein Added: AAN76093.1 iroN siderophore salmochelin receptor IroN Protein Added: AAN77057.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: AAN77061.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: AAN77063.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: BAI44131.1 agg5A aggregative adherence fimbria V major subunit Agg5A Protein Added: AAD12176.1 srpB solvent efflux RND transporter permease subunit SrpB Protein Added: AAD12177.1 ttgI solvent efflux RND transporter outer membrane subunit SrpC Protein Added: AAD12178.1 srpA solvent efflux RND transporter periplasmic adaptor subunit SrpA Protein Added: AAN78874.1 vactox vacuolating autotransporter toxin Vat Protein Added: AAN79707.1 iroN siderophore salmochelin receptor IroN Protein Added: AAN80033.1 iss increased serum survival lipoprotein Iss Protein Added: AAN83596.1 ireA TonB-dependent siderophore receptor IreA Protein Added: CAB14519.1 arsC thioredoxin-dependent arsenate reductase Protein Added: AAB91079.1 copB copper-binding protein CopB Protein Added: CAA05105.1 copP copper-binding metallochaperone CopP Protein Added: AAB88410.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: EEZ94110.1 sdeA multidrug efflux RND transporter periplasmic adaptor subunit SdeA Protein Added: AAO17297.1 eatA serine protease autotransporter toxin EatA Protein Added: ADA73787.1 ipaH3 T3SS effector E3 ubiquitin-protein ligase IpaH3 Protein Added: ADA76801.1 sepA serine protease autotransporter toxin SepA Protein Added: AAO19475.1 stx1Ad Shiga toxin Stx1d subunit A Protein Added: AAO19476.1 stx1Bd Shiga toxin Stx1d subunit B Protein Added: ADA79992.1 merT mercuric transport protein MerT Protein Added: CBG87859.1 nleB type III secretion system effector arginine glycosyltransferase NleB Protein Added: CBG89712.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: CAD66214.1 vactox vacuolating autotransporter toxin Vat Protein Added: ADB20445.1 toxB toxin B Protein Added: CBG36837.1 eilA HilA family transcriptional regulator EilA Protein Added: CBG36838.1 air inverse autotransporter adhesin EaeX/Air Protein Added: CBG37385.1 aaiC type VI secretion system protein AaiC/Hcp2 Protein Added: CBG27762.1 aatA dispersin export ABC transporter outer membrane protein AatA Protein Added: CBG27784.1 aafB aggregative adherence fimbria II minor subunit AafB Protein Added: CBG27798.1 aafD aggregative adherence fimbria II chaperone AafD Protein Added: CBG27800.1 aafA aggregative adherence fimbria II major subunit AafA Protein Added: CBG27804.1 aggR aggregative adherence transcriptional regulator AggR Protein Added: CBG27807.1 aap dispersin Aap Protein Added: CBG27812.1 aar AggR-activated transcriptional regulator Aar Protein Added: AAD12174.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: AAO49780.1 ttgD toluene efflux RND transporter periplasmic adaptor subunit TtgD Protein Added: AAC38390.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAC38394.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: AAC38400.1 espF type III secretion system LEE effector EspF Protein Added: BAA24822.1 arsA arsenite efflux transporter ATPase subunit ArsA Protein Added: AAA20885.1 astA heat-stable enterotoxin EAST1 Protein Added: AAA23736.1 f17g F17G fimbrial adhesin Protein Added: AAA23737.1 f17a F17A fimbrial adhesin Protein Added: ADD58872.1 espF type III secretion system LEE effector EspF Protein Added: ADD58881.1 eae intimin type gamma Protein Added: ADD58883.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: EFF39147.1 norM sodium-coupled multidrug efflux MATE transporter NorM Protein Added: AAO66617.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: BAJ04486.1 perA BFP system transcriptional regulator PerA Protein Added: BAJ04488.1 perA BFP system transcriptional regulator PerA Protein Added: AAC38219.1 merP mercury resistance system periplasmic binding protein MerP Protein Added: AAC38220.1 merA mercury(II) reductase Protein Added: AAC38221.1 merD mercury resistance co-regulator MerD Protein Added: ADE90928.1 vactox vacuolating autotransporter toxin Vat Protein Added: AAC38229.1 merR mercury resistance transcriptional regulator MerR Protein Added: AAC38230.1 merB organomercurial lyase MerB Protein Added: AAC38231.1 merT mercuric transport protein MerT Protein Added: AAC38232.1 merP mercury resistance system periplasmic binding protein MerP Protein Added: AAC38233.1 merC organomercurial transporter MerC Protein Added: AAC38236.1 merE broad-spectrum mercury transporter MerE Protein Added: ADF64798.1 ncrC Ni(II)/Co(II) efflux transporter permease subunit NcrC Protein Added: CBK85583.1 iroN siderophore salmochelin receptor IroN Protein Added: CBL93318.1 capU putative hexosyltransferase CapU Protein Added: CBL93506.1 lngA type IV pilus longus major pilin Protein Added: ADI59685.1 astA heat-stable enterotoxin EAST1 Protein Added: ADI95409.1 ttgE multidrug efflux RND transporter permease subunit TtgE Protein Added: ADI95411.1 ttgT efflux transport transcriptional regulator TtgT Protein Added: AAP03990.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: AAP18950.1 lpfA long polar fimbria major subunit LpfA-O113 Protein Added: ADK23698.1 qacR multidrug-binding transcriptional regulator QacR Protein Added: ADK73987.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAM22256.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: AAM22257.1 stx2Bd Shiga toxin Stx2d subunit B Protein Added: CAD56174.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: CAD56186.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: AAA16360.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: AAA16361.1 stx2Bb Shiga toxin Stx2b subunit B Protein Added: AAA16362.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: ADM83435.1 nleA type III secretion system effector NleA Protein Added: ADN71659.1 iss increased serum survival lipoprotein Iss Protein Added: AAP37403.1 stx2Ag Shiga toxin Stx2g subunit A Protein Added: AAC26634.1 pet serine protease autotransporter toxin Pet Protein Added: CBJ04488.1 cfaC CFA/I pilus usher protein CfaC Protein Added: AAC15683.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: ADO96486.1 hmrM sodium-coupled multidrug efflux MATE transporter HmrM Protein Added: ADP02162.1 merA mercury(II) reductase Protein Added: CAA73506.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: ADR26561.1 iss increased serum survival lipoprotein Iss Protein Added: ADR70747.1 copA laccase-like oxidase CopA Protein Added: ADR70748.1 copB copper-binding protein CopB Protein Added: BAC77251.1 sdeY multidrug efflux RND transporter permease subunit SdeY Protein Added: ADW66881.1 arsH arsenic resistance NADPH-dependent reductase ArsH Protein Added: AAP78989.1 ipaD type III secretion system needle tip complex protein IpaD Protein Added: BAC78639.1 stx1Aa Shiga toxin Stx1a subunit A Protein Added: BAC78640.1 stx1Ba Shiga toxin Stx1a subunit B Protein Added: AAC69314.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAC69318.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: BAJ79293.1 aafA aggregative adherence fimbria II major subunit AafA Protein Added: BAJ79295.1 aafA aggregative adherence fimbria II major subunit AafA Protein Added: BAJ79296.1 aafA aggregative adherence fimbria II major subunit AafA Protein Added: BAJ79297.1 aafA aggregative adherence fimbria II major subunit AafA Protein Added: BAJ79299.1 agg5A aggregative adherence fimbria V major subunit Agg5A Protein Added: BAJ79300.1 agg5A aggregative adherence fimbria V major subunit Agg5A Protein Added: ADY84088.1 nreB nickel resistance MFS transporter NreB Protein Added: AAC24352.1 ehxA enterohemolysin Protein Added: ADZ45128.1 ehxA enterohemolysin Protein Added: AAP88295.1 copA laccase-like oxidase CopA Protein Added: AEC46567.1 copA laccase-like oxidase CopA Protein Added: AEC46568.1 copB copper-binding protein CopB Protein Added: AAC38671.1 ttgB multidrug efflux RND transporter permease subunit TtgB Protein Added: BAA31774.1 ehxA enterohemolysin Protein Added: BAA31815.1 toxB toxin B Protein Added: BAA31832.1 katP catalase/peroxidase KatP Protein Added: BAA31836.1 espP serine protease autotransporter EspP Protein Added: AAQ17236.1 mco multi-copper oxidase Mco Protein Added: AAQ17546.1 stx2Ae Shiga toxin Stx2e subunit A Protein Added: CAA74174.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: AEG95593.1 iroN siderophore salmochelin receptor IroN Protein Added: AAQ20107.1 cfaC CFA/I pilus usher protein CfaC Protein Added: AEK01061.1 iroN siderophore salmochelin receptor IroN Protein Added: AAC31499.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: AAY90617.2 emhA efflux RND transporter periplasmic adaptor subunit EmhA Protein Added: CAA12346.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: CAA12348.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: AEM17342.1 cdtB cytolethal distending toxin nuclease subunit CdtB Protein Added: AAC33154.1 lngA type IV pilus longus major pilin Protein Added: AEQ14997.1 eilA HilA family transcriptional regulator EilA Protein Added: AEQ15694.1 capU putative hexosyltransferase CapU Protein Added: AAC33908.1 merC organomercurial transporter MerC Protein Added: CCE21264.1 agg3A aggregative adherence fimbria 3 major subunit Agg3A Protein Added: EHE72460.1 pmrA multidrug efflux MFS transporter PmrA Protein Added: EHF16244.1 aatA dispersin export ABC transporter outer membrane protein AatA Protein Added: EHF16297.1 aggB aggregative adherence fimbria I minor subunit AggB Protein Added: EHF16298.1 aggA aggregative adherence fimbria I major subunit AggA Protein Added: AET11941.1 nleA type III secretion system effector NleA Protein Added: AET11995.1 nleA type III secretion system effector NleA Protein Added: AET12008.1 nleA type III secretion system effector NleA Protein Added: BAL46940.1 eae intimin type alpha Protein Added: BAL46941.1 eae intimin type epsilon Protein Added: BAL47132.1 eae intimin type epsilon Protein Added: BAL47176.1 eae intimin type rho Protein Added: BAL47179.1 eae intimin type epsilon Protein Added: BAL47181.1 eae intimin type alpha Protein Added: AEZ42789.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AEZ43710.1 nleA type III secretion system effector NleA Protein Added: AAQ92182.1 emhC efflux RND transporter outer membrane subunit EmhC Protein Added: CAA77068.1 aggA aggregative adherence fimbria I major subunit AggA Protein Added: AAR02190.1 aggA aggregative adherence fimbria I major subunit AggA Protein Added: BAL72684.1 cdtB cytolethal distending toxin nuclease subunit CdtB Protein Added: BAL72697.1 cdtB cytolethal distending toxin nuclease subunit CdtB Protein Added: AAR12207.1 cdtB cytolethal distending toxin type III/V nuclease subunit CdtB Protein Added: AAC69584.1 ybtQ yersiniabactin ABC transporter ATP-binding/permease protein YbtQ Protein Added: AAR13270.1 iroN siderophore salmochelin receptor IroN Protein Added: AFH14350.1 faeG F4 fimbrial adhesin subunit FaeG Protein Added: CAD87828.1 sta1 heat-stable enterotoxin ST-I group a Protein Added: BAA34299.1 mexX multidrug efflux RND transporter periplasmic adaptor subunit MexX Protein Added: AFK88558.1 auto-sat serine protease autotransporter toxin Sat Protein Added: AFM31243.1 tccP Tir-cytoskeleton coupling protein TccP2 Protein Added: AFM70729.1 copA copper-translocating P-type ATPase CopA Protein Added: AFM70730.1 copB copper/silver-translocating P-type ATPase CopB Protein Added: AAC82360.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: AAR82963.1 nirA nickel resistance membrane nickel efflux protein NirA Protein Added: AAR82964.1 nirB nickel-sensing transcriptional repressor NirB Protein Added: AAR82966.1 nirD nickel resistance OB fold protein NirD Protein Added: AFQ65076.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: CAA50007.1 cnf1 cytotoxic necrotizing factor CNF1 Protein Added: CAA12345.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: CAA12350.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: CAA12351.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: AFS59871.1 sepA serine protease autotransporter toxin SepA Protein Added: AFS85685.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: AAC99337.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: CAA21388.1 ybtP yersiniabactin ABC transporter ATP-binding/permease protein YbtP Protein Added: BAA36431.1 merR mercury resistance transcriptional regulator MerR Protein Added: BAA36433.1 merD mercury resistance co-regulator MerD Protein Added: CAA40744.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: CAA23532.1 ltcA heat-labile enterotoxin LT subunit A Protein Added: CAA32535.1 fim41a fimbrial adhesin F41 protein Fim41a Protein Added: AAD05936.1 copP copper-binding metallochaperone CopP Protein Added: AAS07580.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: AAS07581.1 stx2Bc Shiga toxin Stx2c subunit B Protein Added: AAS07582.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: AAS07586.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: AAS07588.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: AAS07589.1 stx2Bd Shiga toxin Stx2d subunit B Protein Added: AAS07590.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: AAS07596.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: AAS07600.1 stx2Aa Shiga toxin Stx2a subunit A Protein Added: AAS07606.1 stx2Aa Shiga toxin Stx2a subunit A Protein Added: AAD11743.1 silE silver-binding protein SilE Protein Added: AAD11746.1 silC Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC Protein Added: AAD11748.1 silB Cu(+)/Ag(+) efflux RND transporter periplasmic adaptor subunit SilB Protein Added: AAD11749.1 silA Cu(+)/Ag(+) efflux RND transporter permease subunit SilA Protein Added: AAD11750.1 silP Ag(+)-translocating P-type ATPase SilP Protein Added: AFX83959.1 subA subtilase AB5 cytotoxin subunit A Protein Added: AAS21297.1 tbtR tribuytltin resistance regulator TbtR Protein Added: CAA43585.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: AAD15663.1 tbtA multidrug efflux RND transporter periplasmic adaptor subunit TbtA Protein Added: AAD15664.1 tbtB multidrug efflux RND transporter permease subunit TbtB Protein Added: AAD15665.1 tbtM multidrug efflux RND transporter outer membrane channel subunit TbtM Protein Added: AAD17509.1 f17a F17A fimbrial adhesin Protein Added: AAD17510.1 f17a F17A fimbrial adhesin Protein Added: AAD17511.1 f17a F17A fimbrial adhesin Protein Added: AAD17513.1 f17g F17G fimbrial adhesin Protein Added: AAD17514.1 f17g F17G fimbrial adhesin Protein Added: AAD17515.1 f17g F17G fimbrial adhesin Protein Added: AAA18786.1 cdtB cytolethal distending toxin type II nuclease subunit CdtB Protein Added: CAA77320.1 merR mercury resistance transcriptional regulator MerR Protein Added: CAA77324.1 merD mercury resistance co-regulator MerD Protein Added: CAA77325.1 merE broad-spectrum mercury transporter MerE Protein Added: CAA81047.1 mtrR multidrug efflux system transcriptional repressor MtrR Protein Added: AAA74436.1 mexA multidrug efflux RND transporter periplasmic adaptor subunit MexA Protein Added: AGC14252.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: AAS47019.1 nleC type III secretion system effector zinc metalloprotease NleC Protein Added: AGC85979.1 iss increased serum survival lipoprotein Iss Protein Added: CCG33322.1 iroN siderophore salmochelin receptor IroN Protein Added: AAS50165.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: AAO18187.2 sdeB multidrug efflux RND transporter permease subunit SdeB Protein Added: AAA98221.1 merR mercury resistance transcriptional regulator MerR Protein Added: AAS76847.1 fedA F18 fimbrial major subunit FedA Protein Added: AAD25959.1 merR2 mercury resistance transcriptional regulator MerR2 Protein Added: AAA98245.1 merA mercury(II) reductase Protein Added: AAD27810.1 aafC aggregative adherence fimbria II usher protein AafC Protein Added: AAA24698.1 tsh temperature-sensitive protease autotransporter hemagglutinin Tsh Protein Added: CAE82650.1 faeG F4 fimbrial adhesin subunit FaeG Protein Added: CAE82653.1 faeG F4 fimbrial adhesin subunit FaeG Protein Added: CAE82670.1 faeG F4 fimbrial adhesin subunit FaeG Protein Added: AAD28079.1 hlyE hemolysin HlyE Protein Added: CAA83535.1 aggR aggregative adherence transcriptional regulator AggR Protein Added: EMS03085.1 aggA aggregative adherence fimbria I major subunit AggA Protein Added: CAE55775.1 auto-sat serine protease autotransporter toxin Sat Protein Added: AAT36311.1 rpeA serine protease autotransporter colonization factor RpeA Protein Added: BAA77749.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: BAA77750.1 stx2Bb Shiga toxin Stx2b subunit B Protein Added: BAA77751.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: CAA46767.1 stx2Ab Shiga toxin Stx2b subunit A Protein Added: CAA46768.1 stx2Bb Shiga toxin Stx2b subunit B Protein Added: CAA77936.1 emrE multidrug efflux SMR transporter EmrE Protein Added: AAT65972.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: AAT66000.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: AAT66010.1 stx2Aa Shiga toxin Stx2a subunit A Protein Added: AAT66011.1 stx2Ba Shiga toxin Stx2a subunit B Protein Added: AAT66012.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: AGL46515.1 merF mercury resistance system transport protein MerF Protein Added: AAT68784.1 subB subtilase AB5 cytotoxin subunit B Protein Added: AAT68785.1 subA subtilase AB5 cytotoxin subunit A Protein Added: AAT76975.1 lpfA long polar fimbria major subunit LpfA-O113 Protein Added: AAD39553.1 ttgA toluene efflux RND transporter periplasmic adaptor subunit TtgA Protein Added: AAU01878.1 sepA serine protease autotransporter toxin SepA Protein Added: AAN38824.2 adeE multidrug efflux RND transporter permease subunit AdeE Protein Added: AAU10477.1 adeD multidrug efflux RND transporter periplasmic adaptor subunit AdeD Protein Added: AAU88208.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: AAU88264.1 cdtB cytolethal distending toxin nuclease subunit CdtB Protein Added: AAA57451.1 aggD aggregative adherence fimbria I chaperone AggD Protein Added: AAA57452.1 aggC aggregative adherence fimbria I usher protein AggC Protein Added: AAA57453.1 aggB aggregative adherence fimbria I minor subunit AggB Protein Added: AAA57454.1 aggA aggregative adherence fimbria I major subunit AggA Protein Added: CAA85366.1 stx1Aa Shiga toxin Stx1a subunit A Protein Added: CAA85368.1 stx1Aa Shiga toxin Stx1a subunit A Protein Added: CAA85370.1 stx1Ac Shiga toxin Stx1c subunit A Protein Added: CAA85371.1 stx1Bc Shiga toxin Stx1c subunit B Protein Added: EQX61716.1 aggA aggregative adherence fimbria I major subunit AggA Protein Added: AAU95470.1 nleB type III secretion system effector arginine glycosyltransferase NleB Protein Added: AAU95768.1 mepA multidrug efflux MATE transporter MepA Protein Added: CAG17536.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: CAG17541.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: AAD43578.1 astA heat-stable enterotoxin EAST1 Protein Added: AAD43579.1 astA heat-stable enterotoxin EAST1 Protein Added: CAA85780.1 stx2Aa Shiga toxin Stx2a subunit A Protein Added: AAA80193.1 mtrC multidrug efflux RND transporter periplasmic adaptor subunit MtrC Protein Added: AAD44693.1 mtrA efflux transporter MtrCDE transcriptional activator MtrA Protein Added: AAD47284.1 terZ tellurium resistance-associated protein TerZ Protein Added: AAW38464.1 lmrS multidrug efflux MFS transporter LmrS Protein Added: CAI43856.1 espF type III secretion system LEE effector EspF Protein Added: CAI43860.1 espB type III secretion system LEE translocon pore-forming subunit EspB Protein Added: CAI43862.1 espA type III secretion system LEE translocon filament protein EspA Protein Added: CAI43865.1 eae intimin type epsilon Protein Added: CAI43867.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAD54074.1 farB fatty acid resistance MFS efflux transporter permease subunit FarB Protein Added: BAA84838.1 bfpA bundle-forming pilus major subunit BfpA Protein Added: BAA84859.1 perA BFP system transcriptional regulator PerA Protein Added: AAT35241.2 tsh temperature-sensitive protease autotransporter hemagglutinin Tsh Protein Added: AAF03351.1 espF type III secretion system LEE effector EspF Protein Added: AHW84565.1 aaiC type VI secretion system protein AaiC/Hcp2 Protein Added: AHW84567.1 aaiC type VI secretion system protein AaiC/Hcp2 Protein Added: AAX47728.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAX47729.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAX47730.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAX47731.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: CAA58525.1 pcoA multicopper oxidase PcoA Protein Added: CAA58526.1 pcoB copper-binding protein PcoB Protein Added: CAA58527.1 pcoC copper resistance system metallochaperone PcoC Protein Added: CAA58528.1 pcoD copper resistance inner membrane protein PcoD Protein Added: CAA58529.1 pcoR copper response regulator transcription factor PcoR Protein Added: CAA58530.1 pcoS copper resistance membrane spanning protein PcoS Protein Added: CAA58532.1 pcoE copper resistance system metallochaperone PcoE Protein Added: AAX63244.1 fedF F18 fimbrial adhesin subunit FedF Protein Added: AAX63245.1 fedF F18 fimbrial adhesin subunit FedF Protein Added: AAX63259.1 fedF F18 fimbrial adhesin subunit FedF Protein Added: AAX63270.1 fedF F18 fimbrial adhesin subunit FedF Protein Added: AAY25390.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAY25394.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAY25395.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAF14522.1 mexX multidrug efflux RND transporter periplasmic adaptor subunit MexX Protein Added: CAI91198.1 stx2Ag Shiga toxin Stx2g subunit A Protein Added: AAF16681.1 srpS solvent efflux transporter transcriptional repressor SrpS Protein Added: AAF16682.1 srpR solvent efflux transporter antirepressor SrpR Protein Added: CAA54115.1 nfaE Dr family non-fimbrial adhesin I chaperone NfaE Protein Added: AAF23359.1 eae intimin type epsilon Protein Added: CAB64953.1 stx2Af Shiga toxin Stx2f subunit A Protein Added: AAY63864.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: AAY63865.1 stx2Bd Shiga toxin Stx2d subunit B Protein Added: CDY80020.1 hsp20 small heat shock protein sHSP20 Protein Added: AAY90615.1 emhC efflux RND transporter outer membrane subunit EmhC Protein Added: KGL71342.1 silF Ag(+)/Cu(+) efflux RND transporter periplasmic metallochaperone SilF Protein Added: AAF40764.1 farB fatty acid resistance MFS efflux transporter permease subunit FarB Protein Added: AAF42063.1 mtrC multidrug efflux RND transporter periplasmic adaptor subunit MtrC Protein Added: AAB26855.2 nfaE Dr family non-fimbrial adhesin I chaperone NfaE Protein Added: CAB82448.1 cnrY nickel resistance system anti-sigma factor CnrY Protein Added: AAZ76497.1 ehxA enterohemolysin Protein Added: AAZ76514.1 espP serine protease autotransporter EspP Protein Added: AAZ76524.1 subA subtilase AB5 cytotoxin subunit A Protein Added: AAZ87985.1 ipaH9.8 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 Protein Added: AAZ88030.1 ipaH3 T3SS effector E3 ubiquitin-protein ligase IpaH3 Protein Added: AAZ89804.1 sigA serine protease autotransporter toxin SigA Protein Added: AAZ91108.1 ipaD type III secretion system needle tip complex protein IpaD Protein Added: ABA25986.1 merF mercury resistance system transport protein MerF Protein Added: AAX22079.2 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: AAA65102.1 nccX periplasmic metal sensor NccX Protein Added: AAA65103.1 nccH nickel/cobalt/cadmium resistance ECF sigma factor NccH Protein Added: ABB16332.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: ABB36584.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: ABB36586.1 stx2Ad Shiga toxin Stx2d subunit A Protein Added: ABB61187.1 iroN siderophore salmochelin receptor IroN Protein Added: ABB62096.1 ipaH9.8 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 Protein Added: ABB62098.1 ipaH9.8 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 Protein Added: ABB64677.1 ipaD type III secretion system needle tip complex protein IpaD Protein Added: ABB65884.1 ipaH3 T3SS effector E3 ubiquitin-protein ligase IpaH3 Protein Added: ABB66229.1 ipaH9.8 T3SS effector E3 ubiquitin-protein ligase IpaH9.8 Protein Added: ABB68924.1 virF AraC family invasion system transcriptional regulator VirF Protein Added: KLB41245.1 copL transcriptional regulator CopL Protein Added: CAI79539.1 eatA serine protease autotransporter toxin EatA Protein Added: CAJ44959.1 mchF microcin H47 export transporter peptidase/ATP-binding subunit MchF Protein Added: CAB77169.2 stx2Ae Shiga toxin Stx2e subunit A Protein Added: CAB94149.1 stx2Ba Shiga toxin Stx2a subunit B Protein Added: AAC34727.1 faeG F4 fimbrial adhesin subunit FaeG Protein Added: BAA96815.1 tir type III secretion system LEE translocated intimin receptor Tir Protein Added: AAA69514.1 f17g F17G fimbrial adhesin Protein Added: CAA88252.1 sepA serine protease autotransporter toxin SepA Protein Added: BAE79899.1 smfY multidrug efflux MFS transporter SmfY Protein Added: ABE06598.1 sfaS S-fimbrial adhesin minor subunit SfaS Protein Added: ABE10324.1 cnf1 cytotoxic necrotizing factor CNF1 Protein Added: CAJ34994.1 bfpA bundle-forming pilus major subunit BfpA Protein Added: ABF13034.1 merD mercury resistance co-regulator MerD Protein Added: ABF13067.1 cnrC nickel efflux RND transporter outer membrane subunit CnrC Protein Added: ABF13069.1 cnrA nickel efflux RND transporter permease subunit CnrA Protein Added: ABF13070.1 cnrT nickel diffusion facilitator CnrT Protein Added: ABF14406.1 ncrA Metal Resistance Protein Added: ABF14407.1 ncrB nickel-sensing transcriptional repressor NcrB Protein Added: CAK02719.1 cnf1 cytotoxic necrotizing factor CNF1 Protein Added: CAA90630.1 stx2Aa Shiga toxin Stx2a subunit A Protein Added: BAT41861.1 eae intimin type alpha Protein Added: CAK15125.1 mexE MexE family multidrug efflux RND transporter periplasmic adaptor subunit Protein Added: AAG01033.1 stx2Ac Shiga toxin Stx2c subunit A Protein Added: AAB59153.1 cadC Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory transcriptional repressor CadC Protein Added: ABF61434.1 ncrA Metal Resistance Protein Added: ABF61435.1 ncrB nickel-sensing transcriptional repressor NcrB Protein Added: ABF61437.1 ncrY nickel resistance OB fold protein NcrY Protein Added: AAG05881.1 mexE MexE family multidrug efflux RND transporter periplasmic adaptor subunit Protein Added: AAG10695.1 perA BFP system transcriptional regulator PerA Protein Added: WP_000697899.1 pmrA pmrA Protein Added: WP_097509477.1 acrB acrB - AMRFinder HMM library Changes: Prev. Release: 574 This Release: 610 Removed: 2 Added: 38 Changed: 572 HMM Removed: NF000478.2 linco_LnuE HMM Removed: NF012180.1 tet_MFS_43 HMM Added: NF000131.1 MATE_multi_MepA HMM Added: NF000249.1 MexE HMM Added: NF000252.1 MexX HMM Added: NF000263.1 MATE_multi_NorM HMM Added: NF000282.2 RND_permease_1 HMM Added: NF000314.1 adeB HMM Added: NF000315.1 adeC-adeK-oprM HMM Added: NF000336.1 emrE HMM Added: NF007842.1 PRK10555.1 HMM Added: NF010310.2 PRK13747.1 HMM Added: NF010315.0 PRK13752.1 HMM Added: NF011706.2 PRK15127.1 HMM Added: NF028537.1 P_eth_NH2_trans HMM Added: NF033086.2 penta_rpt_Qnr HMM Added: NF033134.0 cmlA_floR HMM Added: NF033142.1 efflux_OM_AdeC HMM Added: NF033143.1 efflux_OM_AdeK HMM Added: NF033555.1 lyase_MerB HMM Added: NF033560.1 merT_RC607 HMM Added: NF033565.0 trans_MerF HMM Added: NF033627.3 intimin_all HMM Added: NF033637.1 transloc_TIR HMM Added: NF033639.1 intimin_alpha HMM Added: NF033643.1 EspJ_gen HMM Added: NF033646.1 toxin_EAST1 HMM Added: NF033651.1 cyto_nec_fctrs HMM Added: NF033658.1 Shiga_Stx1A HMM Added: NF033659.0 Shiga_Stx1B HMM Added: NF033660.0 Shiga_Stx2B HMM Added: NF033661.1 Shiga_Stx2A HMM Added: NF033727.1 chaperon_ArsD HMM Added: NF033781.1 chaper_CopP HMM Added: NF033783.1 coreg_MerD HMM Added: NF033784.1 transport_merC HMM Added: NF033786.1 phenyl_MerG HMM Added: NF033834.1 RND_adapt_MexA HMM Added: TIGR02052.1 TIGR02052 HMM Added: TIGR02053.1 TIGR02053 --------------------------------------------------------------------- Changes included in 2019-04-29.1 --------------------------------------------------------------------- Summary: In addition to the usual addition of 134 new genes and alleles community feedback led to the renaming of a few dfr genes. The family heirarchy file (fam.tab) was cleaned up by removing a number of superfluous entries. Changes included in 2019-04-29.1 - Protein changes: Prev. Release: 4810 This Release: 4942 Removed: 1 Added: 134 Modified: 3 Protein Removed: WP_109545040.1 chrB Protein Added: WP_000054744.1 satA_Ba Protein Added: WP_001211209.1 blaADC-140 Protein Added: WP_001211210.1 blaADC-185 Protein Added: WP_001211214.1 blaADC-144 Protein Added: WP_001211215.1 blaADC-115 Protein Added: WP_001572373.1 mcr-9.1 Protein Added: WP_002126587.1 blaADC-120 Protein Added: WP_002157727.1 blaADC-117 Protein Added: WP_003112187.1 blaADC-191 Protein Added: WP_003242546.1 satA_Bs Protein Added: WP_004643536.1 blaADC-128 Protein Added: WP_004700205.1 blaADC-133 Protein Added: WP_004707701.1 blaADC-131 Protein Added: WP_004712857.1 blaADC-119 Protein Added: WP_004790939.1 blaADC-135 Protein Added: WP_004840559.1 blaADC-123 Protein Added: WP_004886093.1 blaADC-130 Protein Added: WP_005039111.1 blaADC-129 Protein Added: WP_005046018.1 blaADC-127 Protein Added: WP_005068074.1 blaADC-132 Protein Added: WP_005109685.1 blaADC-121 Protein Added: WP_005123276.1 blaADC-122 Protein Added: WP_005131186.1 blaADC-125 Protein Added: WP_005307218.1 blaADC-134 Protein Added: WP_005404206.1 blaOXA-813 Protein Added: WP_005405613.1 blaOXA-814 Protein Added: WP_013197184.1 blaADC-193 Protein Added: WP_014207272.1 blaADC-149 Protein Added: WP_016137488.1 blaADC-136 Protein Added: WP_016140427.1 blaADC-137 Protein Added: WP_016146025.1 blaADC-138 Protein Added: WP_017386568.1 blaADC-150 Protein Added: WP_017778762.1 mcr-3.27 Protein Added: WP_017816757.1 blaADC-116 Protein Added: WP_026382828.1 blaOXA-114i Protein Added: WP_026444036.1 blaOXA-816 Protein Added: WP_032039838.1 blaADC-139 Protein Added: WP_032053762.1 blaOXA-819 Protein Added: WP_032057042.1 blaOXA-820 Protein Added: WP_032062810.1 blaADC-141 Protein Added: WP_032625176.1 blaACT-66 Protein Added: WP_033502167.1 blaADC-143 Protein Added: WP_034670108.1 blaOXA-818 Protein Added: WP_034688190.1 blaOXA-812 Protein Added: WP_036299413.1 sulR Protein Added: WP_039246976.1 blaADC-148 Protein Added: WP_039258389.1 blaADC-146 Protein Added: WP_039270258.1 blaADC-145 Protein Added: WP_044718369.1 blaADC-147 Protein Added: WP_047726486.1 blaACT-65 Protein Added: WP_053498400.1 blaOXA-114h Protein Added: WP_054437016.1 blaOXA-114j Protein Added: WP_054471662.1 blaOXA-114m Protein Added: WP_054500785.1 blaOXA-789 Protein Added: WP_054517040.1 blaOXA-114l Protein Added: WP_057061999.1 blaOXA-821 Protein Added: WP_059247009.1 blaADC-184 Protein Added: WP_063099318.1 blaADC-151 Protein Added: WP_063147148.1 blaACT-67 Protein Added: WP_072292271.1 blaADC-186 Protein Added: WP_075040046.1 blaOXA-817 Protein Added: WP_076412384.1 blaOXA-114p Protein Added: WP_099595307.1 dfrA35 Protein Added: WP_103663397.1 sulX Protein Added: WP_106743337.1 mcr-1.18 Protein Added: WP_109545052.1 mcr-1.14 Protein Added: WP_110612827.1 blaOXA-796 Protein Added: WP_111280830.1 blaOXA-815 Protein Added: WP_115470049.1 blaKPC-40 Protein Added: WP_117664257.1 cfxA6 Protein Added: WP_125052776.1 blaADC-114 Protein Added: WP_136512051.1 blaACT-68 Protein Added: WP_136512052.1 blaADC-109 Protein Added: WP_136512053.1 blaADC-110 Protein Added: WP_136512054.1 blaADC-112 Protein Added: WP_136512055.1 blaADC-113 Protein Added: WP_136512056.1 blaADC-187 Protein Added: WP_136512057.1 blaADC-188 Protein Added: WP_136512058.1 blaADC-189 Protein Added: WP_136512059.1 blaADC-190 Protein Added: WP_136512060.1 blaADC-192 Protein Added: WP_136512061.1 blaADC-24 Protein Added: WP_136512062.1 blaADC-65 Protein Added: WP_136512063.1 blaADC-66 Protein Added: WP_136512064.1 blaCTX-M-225 Protein Added: WP_136512065.1 blaCTX-M-226 Protein Added: WP_136512066.1 blaFRI-7 Protein Added: WP_136512067.1 blaIMI-18 Protein Added: WP_136512068.1 blaIMP-39 Protein Added: WP_136512069.1 blaIMP-46 Protein Added: WP_136512070.1 blaKPC-42 Protein Added: WP_136512071.1 blaKPC-43 Protein Added: WP_136512072.1 blaNDM-28 Protein Added: WP_136512073.1 blaOXA-114k Protein Added: WP_136512074.1 blaOXA-114n Protein Added: WP_136512075.1 blaOXA-114q Protein Added: WP_136512076.1 blaOXA-114r Protein Added: WP_136512077.1 blaOXA-114s Protein Added: WP_136512078.1 blaOXA-114t Protein Added: WP_136512079.1 blaOXA-114u Protein Added: WP_136512080.1 blaOXA-114v Protein Added: WP_136512081.1 blaOXA-114w Protein Added: WP_136512082.1 blaOXA-114x Protein Added: WP_136512083.1 blaOXA-787 Protein Added: WP_136512084.1 blaOXA-788 Protein Added: WP_136512085.1 blaOXA-793 Protein Added: WP_136512086.1 blaOXA-794 Protein Added: WP_136512087.1 blaOXA-795 Protein Added: WP_136512088.1 blaOXA-797 Protein Added: WP_136512089.1 blaOXA-798 Protein Added: WP_136512090.1 blaOXA-799 Protein Added: WP_136512091.1 blaOXA-800 Protein Added: WP_136512092.1 blaOXA-801 Protein Added: WP_136512093.1 blaOXA-802 Protein Added: WP_136512094.1 blaOXA-803 Protein Added: WP_136512095.1 blaOXA-804 Protein Added: WP_136512096.1 blaOXA-805 Protein Added: WP_136512097.1 blaOXA-806 Protein Added: WP_136512098.1 blaOXA-807 Protein Added: WP_136512099.1 blaOXA-808 Protein Added: WP_136512100.1 blaOXA-809 Protein Added: WP_136512101.1 blaOXA-810 Protein Added: WP_136512102.1 blaOXA-811 Protein Added: WP_136512103.1 blaOXA-823 Protein Added: WP_136512104.1 blaOXA-824 Protein Added: WP_136512105.1 blaPER-13 Protein Added: WP_136512106.1 blaVIM-48 Protein Added: WP_136512107.1 blaVIM-55 Protein Added: WP_136512108.1 blaVIM-63 Protein Added: WP_136512109.1 blaVIM-66 Protein Added: WP_136512110.1 mcr-1.16 Protein Added: WP_136512111.1 mcr-1.17 Protein Added: WP_136512112.1 mcr-3.29 Protein Modified: WP_001031075.1 dfr18 updated to WP_001031075.1 dfrA18 Protein Modified: WP_032490189.1 dfrA18 updated to WP_032490189.1 dfrA19 Protein Modified: WP_063843245.1 chrB updated to WP_063843245.1 chrB_rRNA_meth - AMR HMM library Changes: Prev. Release: 571 This Release: 574 Removed: 0 Added: 3 Changed: 571 HMM Added: NF033818.0 blaOXA-114_like HMM Added: NF033836.1 polymyxin_MCR9 HMM Added: NF033851.1 trim_DfrA35 HMM Modified: NF000039.1 trim_Dfr18 renamed to NF000039.1 trim_DfrA18 HMM Modified: NF000041.1 trim_DfrA18_A19 renamed to NF000041.1 trim_DfrA19 HMM Modified: NF000422.2 blaPDC updated to NF000422.6 blaPDC - Protein family changes: Prev. Release: 1177 This Release: 1119 Removed: 68 Added: 10 Modified: 4 Family Removed: - PORIN Family Removed: - aac(1) Family Removed: - aac(3')-IIe Family Removed: - aac(3)-Ie Family Removed: - aac(3)-VI Family Removed: - aac(3)-Vb Family Removed: - aac(6')-Ib8 Family Removed: - aacA44 Family Removed: - aadA1bt Family Removed: - aadA1r Family Removed: - aadA24 Family Removed: - ampC_Eae Family Removed: - ampH Family Removed: - ampS Family Removed: - ant(3'')(9) Family Removed: - ant(3'')-Ii Family Removed: - aph(3')-Ic Family Removed: - arr-Cb Family Removed: - blaCMG Family Removed: - blaKLUG Family Removed: - blaLMB Family Removed: - blaMSI-OXA Family Removed: - blaOXA_missing Family Removed: - blaPNGM Family Removed: - blaZEG Family Removed: - blmS Family Removed: - catA12 Family Removed: - ccrA Family Removed: NF000488.1 chrB Family Removed: - cml Family Removed: - cmlA7 Family Removed: - cmlA9 Family Removed: NF000039.1 dfr18 Family Removed: NF000041.1 dfrA18_dfrA19 Family Removed: - dfrA1_var Family Removed: - dfrA29 Family Removed: - dfrA33 Family Removed: - dfrB7 Family Removed: - flo Family Removed: - mef(E) Family Removed: - mef(G) Family Removed: - mef(I) Family Removed: - mph(D) Family Removed: - nimF Family Removed: - nimH Family Removed: - omp35 Family Removed: - ompE35 Family Removed: - otr(C) Family Removed: - penA Family Removed: - sat2A Family Removed: - sat3A Family Removed: - spc Family Removed: - sul1delta Family Removed: - vanH-Ac2 Family Removed: - vanH-F Family Removed: - vanR-Pt Family Removed: - vanR-Pt2 Family Removed: - vanS-I Family Removed: - vanSc Family Removed: - vanTc4 Family Removed: - vanX-Ac2 Family Removed: - vanX-F Family Removed: - vanX-Pt2 Family Removed: - vanY-40021673 Family Removed: - vanY-D4 Family Removed: - vanY-D5 Family Removed: - vanY-M Family Removed: - vanY-Pt2 Family Added: NF033818.0 blaOXA-114_like Family Added: NF033851.1 dfrA35 Family Added: NF033124.1 estX Family Added: NF033836.1 mcr-9 Family Added: - satA_Bs Family Added: - sulR Family Added: - sulX Family Changed: NF000422.2 blaPDC updated to NF000422.6 blaPDC Family Changed: NF000488.1 chrB renamed to chrB_rRNA_meth Family Changed: NF000039.1 dfr18 renamed to dfrA18 Family Changed: NF000041.1 dfrA18_dfrA19 renamed to dfrA19 --------------------------------------------------------------------- Changes included in 2019-02-08.1 --------------------------------------------------------------------- Two incorrectly assigned proteins were accidentally released. They are not AMR proteins and should not have been released. This release simply removes them and is otherwise unchanged. - Protein changes: Prev. Release: 4812 This Release: 4810 Removed: 2 Added: 0 Changed: 4810 Protein Removed: WP_000122253.1 sat Protein Removed: WP_001045652.1 sat --------------------------------------------------------------------- Changes included in 2019-02-04.1 --------------------------------------------------------------------- - Protein name changes: "inhibitor-resistant" was added to the names of: blaKPC-8 blaKPC-30 blaKPC-31 blaKPC-32 blaKPC-33 - Protein changes: Prev. Release: 4730 This Release: 4812 Removed: 0 Added: 82 Protein modified: WP_063855700.1 tet(35) replaced with WP_005480402.1 Protein Added: WP_000122253.1 sat Protein Added: WP_001045652.1 sat Protein Added: WP_002415638.1 poxtA Protein Added: WP_003234144.1 vmlR Protein Added: WP_029728367.1 blaB Protein Added: WP_044103626.1 blaVEB-21 Protein Added: WP_046693238.1 blaADC-181 Protein Added: WP_049637206.1 blaOXA-780 Protein Added: WP_057691114.1 blaADC-182 Protein Added: WP_058492019.1 vanI Protein Added: WP_065980086.1 blaOXA-784 Protein Added: WP_069953510.1 blaAFM-1 Protein Added: WP_069996660.1 mecC3 Protein Added: WP_071223118.1 taeA Protein Added: WP_087343787.1 ant(6)-Ic Protein Added: WP_087344360.1 blaBBI Protein Added: WP_087344902.1 catV Protein Added: WP_087346196.1 ant(4')-Ic Protein Added: WP_087347987.1 rphC Protein Added: WP_087348261.1 rphD Protein Added: WP_087349244.1 mphJ Protein Added: WP_087349651.1 aac(6')-35 Protein Added: WP_114225343.1 blaOXA-739 Protein Added: WP_123002100.1 blaGES-40 Protein Added: WP_123002101.1 blaKPC-38 Protein Added: WP_123002102.1 blaNDM-27 Protein Added: WP_123002103.1 blaVIM-61 Protein Added: WP_126205827.1 blaOXA-785 Protein Added: WP_127728991.1 blaFRI-6 Protein Added: WP_128268231.1 mecC2 Protein Added: WP_128268232.1 blaADC-183 Protein Added: WP_128268233.1 blaCARB-50 Protein Added: WP_128268234.1 blaCFE-2 Protein Added: WP_128268235.1 blaCTX-M-215 Protein Added: WP_128268236.1 blaDHA-28 Protein Added: WP_128268237.1 blaKPC-39 Protein Added: WP_128268238.1 blaOXA-738 Protein Added: WP_128268239.1 blaOXA-740 Protein Added: WP_128268240.1 blaOXA-741 Protein Added: WP_128268241.1 blaOXA-742 Protein Added: WP_128268242.1 blaOXA-743 Protein Added: WP_128268243.1 blaOXA-744 Protein Added: WP_128268244.1 blaOXA-745 Protein Added: WP_128268245.1 blaOXA-746 Protein Added: WP_128268246.1 blaOXA-747 Protein Added: WP_128268247.1 blaOXA-748 Protein Added: WP_128268248.1 blaOXA-749 Protein Added: WP_128268249.1 blaOXA-750 Protein Added: WP_128268250.1 blaOXA-751 Protein Added: WP_128268251.1 blaOXA-752 Protein Added: WP_128268252.1 blaOXA-753 Protein Added: WP_128268253.1 blaOXA-754 Protein Added: WP_128268254.1 blaOXA-755 Protein Added: WP_128268255.1 blaOXA-756 Protein Added: WP_128268256.1 blaOXA-757 Protein Added: WP_128268257.1 blaOXA-758 Protein Added: WP_128268258.1 blaOXA-759 Protein Added: WP_128268259.1 blaOXA-760 Protein Added: WP_128268260.1 blaOXA-761 Protein Added: WP_128268261.1 blaOXA-762 Protein Added: WP_128268262.1 blaOXA-763 Protein Added: WP_128268263.1 blaOXA-764 Protein Added: WP_128268264.1 blaOXA-765 Protein Added: WP_128268265.1 blaOXA-766 Protein Added: WP_128268266.1 blaOXA-767 Protein Added: WP_128268267.1 blaOXA-768 Protein Added: WP_128268268.1 blaOXA-769 Protein Added: WP_128268269.1 blaOXA-770 Protein Added: WP_128268270.1 blaOXA-771 Protein Added: WP_128268271.1 blaOXA-772 Protein Added: WP_128268272.1 blaOXA-773 Protein Added: WP_128268273.1 blaOXA-774 Protein Added: WP_128268274.1 blaOXA-775 Protein Added: WP_128268275.1 blaOXA-776 Protein Added: WP_128268276.1 blaOXA-781 Protein Added: WP_128268277.1 blaOXA-782 Protein Added: WP_128268278.1 blaOXA-783 Protein Added: WP_128268279.1 blaOXA-786 Protein Added: WP_128268280.1 blaPDC-317 Protein Added: WP_128268286.1 blaVEB-20 Protein Added: WP_128268287.1 blaVIM-62 Protein Added: WP_128268288.1 qnrS15 - AMR HMM library Changes: Prev. Release: 568 This Release: 571 Removed: 0 Added: 3 HMM Added: NF033714.1 blaBBI HMM Added: NF033736.1 blaAFM HMM Added: NF033815.0 blaOXA-364_like HMM Modified: NF000355.2 ribo_prot_ABC_F updated to NF000355.3 ribo_prot_ABC_F - Protein family changes: Prev. Release: 1161 This Release: 1177 Removed: 0 Added: 16 Family Added: - aac(6')-35 Family Added: - ant(4')-Ic Family Added: - ant(6)-Ic Family Added: NF033736.1 blaAFM Family Added: NF033714.1 blaBBI Family Added: NF033815.0 blaOXA-364_like Family Added: - mecC2 Family Added: - mecC3 Family Added: - mphJ Family Added: - poxtA Family Added: - rphC Family Added: - rphD Family Added: - rph_gen Family Added: - satA_Ba Family Added: - taeA Family Added: - vmlR Family Changed: NF000355.2 abc-f updated to NF000355.3 abc-f --------------------------------------------------------------------- Changes included in 2018-11-07.1 --------------------------------------------------------------------- Due to a communication error three blaOXA alleles in the AMR database have been reassigned. Alleles published by Tian, et al. (PMID:30247543) have replaced them. AFY12006.1 JX846494.1 WP_072678505.1 NG_061615.1 were blaOXA-669, now they are blaOXA-732 AAL47570.1 AY066004.1 WP_114699266.1 NG_061383.1 were blaOXA-666, now they are blaOXA-729 AXH06203.1 MH684781.1 WP_116786836.1 NG_061623.1 were blaOXA-667, now they are blaOXA-730 - Protein changes: Prev. Release: 4579 This Release: 4730 Removed: 0 Added: 151 Protein Added: WP_004143591.1 blaSHV-206 Protein Added: WP_004384957.1 blaCSA-2 Protein Added: WP_007888761.1 blaCSA-1 Protein Added: WP_011245929.1 clbB Protein Added: WP_011707905.1 blaOXA-725 Protein Added: WP_012116915.1 clbA Protein Added: WP_015892743.1 clbC Protein Added: WP_016162389.1 blaOXA-673 Protein Added: WP_016168805.1 blaOXA-664 Protein Added: WP_016651348.1 blaOXA-670 Protein Added: WP_016657654.1 blaOXA-665 Protein Added: WP_016660101.1 blaOXA-671 Protein Added: WP_016685888.1 blaOXA-715 Protein Added: WP_017822040.1 qnrVC10 Protein Added: WP_023271137.1 blaOXA-672 Protein Added: WP_023341517.1 blaSHV-211 Protein Added: WP_031998610.1 blaOXA-716 Protein Added: WP_032018141.1 blaOXA-717 Protein Added: WP_032495491.1 blaKLUC-3 Protein Added: WP_032495492.1 blaKLUC-4 Protein Added: WP_032974004.1 blaCMA-1 Protein Added: WP_033179079.1 crpP Protein Added: WP_034612711.1 blaOXA-668 Protein Added: WP_056517622.1 blaOXA-669 Protein Added: WP_057097547.1 aph(2'')-If2 Protein Added: WP_058652112.1 dfrA34 Protein Added: WP_064733493.1 blaSHV-207 Protein Added: WP_064760451.1 qepA4 Protein Added: WP_064768701.1 qepA7 Protein Added: WP_077096319.1 blaOXA-724 Protein Added: WP_081406929.1 blaOXA-674 Protein Added: WP_081853183.1 blaELM-1 Protein Added: WP_092689909.1 blaOXA-666 Protein Added: WP_094166899.1 blaCTX-M-224 Protein Added: WP_096735335.1 blaOXA-667 Protein Added: WP_096941464.1 qepA6 Protein Added: WP_100663667.1 blaKLUC-5 Protein Added: WP_101150415.1 blaOXA-726 Protein Added: WP_104159136.1 blaSHV-224 Protein Added: WP_105620838.1 blaCMA-2 Protein Added: WP_109232473.1 blaSHV-220 Protein Added: WP_109638756.1 qepA8 Protein Added: WP_112021705.1 qepA9 Protein Added: WP_113334341.1 qepA10 Protein Added: WP_115196748.1 blaSHV-210 Protein Added: WP_117241614.1 blaSHV-223 Protein Added: WP_122630822.1 blaEFM-1 Protein Added: WP_122630823.1 blaEVM-1 Protein Added: WP_122630824.1 blaECM-1 Protein Added: WP_122630825.1 blaEAM-1 Protein Added: WP_122630826.1 blaGES-38 Protein Added: WP_122630827.1 blaGES-39 Protein Added: WP_122630828.1 blaVIM-53 Protein Added: WP_122630829.1 blaDHT2-1 Protein Added: WP_122630830.1 blaSPN79-1 Protein Added: WP_122630831.1 blaCRD3-1 Protein Added: WP_122630832.1 blaALG6-1 Protein Added: WP_122630833.1 blaALG11-1 Protein Added: WP_122630834.1 blaGRD33-1 Protein Added: WP_122630835.1 blaGRD23-1 Protein Added: WP_122630836.1 blaCMY-158 Protein Added: WP_122630837.1 blaCMY-159 Protein Added: WP_122630838.1 blaSHV-201 Protein Added: WP_122630839.1 blaSHV-202 Protein Added: WP_122630840.1 aph(2'') Protein Added: WP_122630841.1 blaTEM-237 Protein Added: WP_122630842.1 blaOXA-655 Protein Added: WP_122630843.1 blaOXA-656 Protein Added: WP_122630844.1 blaOXA-733 Protein Added: WP_122630845.1 blaPDC-307 Protein Added: WP_122630846.1 blaPDC-308 Protein Added: WP_122630847.1 blaPDC-309 Protein Added: WP_122630848.1 blaPDC-310 Protein Added: WP_122630849.1 blaPDC-311 Protein Added: WP_122630850.1 blaPDC-312 Protein Added: WP_122630851.1 blaPDC-313 Protein Added: WP_122630852.1 blaPDC-314 Protein Added: WP_122630853.1 blaOXA-734 Protein Added: WP_122630854.1 blaOXA-735 Protein Added: WP_122630855.1 blaOXA-736 Protein Added: WP_122630856.1 blaOXA-737 Protein Added: WP_122630857.1 blaOXA-675 Protein Added: WP_122630858.1 blaOXA-676 Protein Added: WP_122630859.1 blaOXA-677 Protein Added: WP_122630860.1 blaOXA-678 Protein Added: WP_122630861.1 blaIMP-80 Protein Added: WP_122630862.1 blaCTX-M-223 Protein Added: WP_122630863.1 blaSHV-205 Protein Added: WP_122630864.1 blaOXA-680 Protein Added: WP_122630865.1 blaSHV-208 Protein Added: WP_122630866.1 blaSHV-209 Protein Added: WP_122630867.1 blaSHV-212 Protein Added: WP_122630868.1 blaSHV-213 Protein Added: WP_122630869.1 blaSHV-214 Protein Added: WP_122630870.1 blaSHV-215 Protein Added: WP_122630871.1 blaSHV-216 Protein Added: WP_122630872.1 blaSHV-217 Protein Added: WP_122630873.1 blaSHV-218 Protein Added: WP_122630874.1 blaSHV-219 Protein Added: WP_122630875.1 blaSHV-221 Protein Added: WP_122630876.1 blaSHV-222 Protein Added: WP_122630877.1 blaSHV-225 Protein Added: WP_122630878.1 blaSHV-226 Protein Added: WP_122630879.1 blaSHV-227 Protein Added: WP_122630880.1 blaSHV-228 Protein Added: WP_122630881.1 blaOXA-681 Protein Added: WP_122630882.1 blaPDC-315 Protein Added: WP_122630883.1 blaPDC-316 Protein Added: WP_122630884.1 blaOXA-682 Protein Added: WP_122630885.1 blaOXA-683 Protein Added: WP_122630886.1 blaOXA-684 Protein Added: WP_122630887.1 blaOXA-685 Protein Added: WP_122630888.1 blaOXA-686 Protein Added: WP_122630889.1 blaOXA-687 Protein Added: WP_122630890.1 blaOXA-688 Protein Added: WP_122630891.1 blaOXA-689 Protein Added: WP_122630892.1 blaOXA-690 Protein Added: WP_122630893.1 blaOXA-691 Protein Added: WP_122630894.1 blaOXA-692 Protein Added: WP_122630895.1 blaOXA-693 Protein Added: WP_122630896.1 blaOXA-694 Protein Added: WP_122630897.1 blaOXA-695 Protein Added: WP_122630898.1 blaOXA-696 Protein Added: WP_122630899.1 blaOXA-697 Protein Added: WP_122630900.1 blaOXA-698 Protein Added: WP_122630901.1 blaOXA-699 Protein Added: WP_122630902.1 blaOXA-700 Protein Added: WP_122630903.1 blaOXA-701 Protein Added: WP_122630904.1 blaOXA-702 Protein Added: WP_122630905.1 blaOXA-703 Protein Added: WP_122630906.1 blaOXA-704 Protein Added: WP_122630907.1 blaOXA-705 Protein Added: WP_122630908.1 blaOXA-706 Protein Added: WP_122630909.1 blaOXA-707 Protein Added: WP_122630910.1 blaOXA-718 Protein Added: WP_122630911.1 blaOXA-719 Protein Added: WP_122630912.1 blaOXA-720 Protein Added: WP_122630913.1 blaOXA-721 Protein Added: WP_122630914.1 blaOXA-722 Protein Added: WP_122630915.1 blaOXA-723 Protein Added: WP_122630916.1 blaOXA-708 Protein Added: WP_122630917.1 blaOXA-709 Protein Added: WP_122630918.1 blaOXA-710 Protein Added: WP_122630919.1 blaOXA-711 Protein Added: WP_122630920.1 blaOXA-712 Protein Added: WP_122630921.1 blaOXA-713 Protein Added: WP_122630922.1 blaOXA-714 Protein Added: WP_122630923.1 blaOXA-777 Protein Added: WP_122630924.1 blaOXA-778 Protein Added: WP_122634438.1 blaOXA-779 Protein Added: WP_122634439.1 blaOXA-679 Gene Symbol Modified: WP_010890145.1 qacE_gen updated to WP_010890145.1 qacE Gene Symbol Modified: WP_053515552.1 qacE_gen updated to WP_053515552.1 qacE Gene Symbol Modified: WP_063844281.1 cphA updated to WP_063844281.1 cphA3 Gene Symbol Modified: WP_063854778.1 qepA updated to WP_063854778.1 qepA5 Gene Symbol Modified: WP_072678505.1 blaOXA-669 updated to WP_072678505.1 blaOXA-732 Gene Symbol Modified: WP_114699266.1 blaOXA-666 updated to WP_114699266.1 blaOXA-729 Gene Symbol Modified: WP_116786836.1 blaOXA-667 updated to WP_116786836.1 blaOXA-730 - AMR HMM library Changes: Prev. Release: 563 This Release: 568 Removed: 0 Added: 5 HMM Added: NF033692.1 APH_2pp_I_a_f_h HMM Added: NF033693.0 AAC_6p_Ie_fam HMM Added: NF033698.1 blaCSA HMM Added: NF033700.1 blaCMA HMM Added: NF033702.0 blaOXA-12_like HMM Name Modified: NF033666.1 blaOXA-664_like updated to NF033666.1 blaOXA-727_like - Protein family changes: Prev. Release: 1133 This Release: 1161 Removed: 0 Added: 28 Family Added: - aac(6')-Ie2 Family Added: NF033693.0 aac(6')-Ie_fam Family Added: NF011706.2 acrB Family Added: NF007842.1 acrD Family Added: NF000314.1 adeB/adeJ Family Added: NF033692.1 aph(2'')-I_a_f_h Family Added: - aph(2'')-If2 Family Added: - blaALG11 Family Added: - blaALG6 Family Added: NF033700.1 blaCMA Family Added: - blaCRD3 Family Added: NF033698.1 blaCSA Family Added: - blaCrA Family Added: - blaDHT2 Family Added: - blaEAM Family Added: - blaECM Family Added: - blaEFM Family Added: - blaELM Family Added: - blaEVM Family Added: - blaGRD23 Family Added: - blaGRD33 Family Added: NF033702.0 blaOXA-12_like Family Added: - blaPNGM Family Added: - blaSPN79 Family Added: - catV Family Added: - crpP Family Added: - dfrA34 Family Added: - qacE Family Renamed: NF033666.1 blaOXA-664_like became blaOXA-727_like --------------------------------------------------------------------- Changes included in 2018-09-14.1 ---------------------------------------------------------------------- - Protein changes: Prev. Release: 4569 This Release: 4579 Removed: 0 Added: 10 Protein Added: WP_116786828.1 mcr-4.6 Protein Added: WP_116786829.1 blaCTX-M-222 Protein Added: WP_116786830.1 mcr-1.15 Protein Added: WP_116786831.1 blaTEM-236 Protein Added: WP_116786832.1 blaKPC-37 Protein Added: WP_116786834.1 blaPDC-304 Protein Added: WP_116786836.1 blaOXA-667 Protein Added: WP_116786837.1 blaPDC-305 Protein Added: WP_116786838.1 blaPDC-306 Protein Added: WP_116786839.1 blaIMP-79 - AMR HMM library Changes: Prev. Release: 563 This Release: 563 Removed: 0 Added: 0 - Protein family changes: Prev. Release: 1133 This Release: 1133 Removed: 0 Added: 0 --------------------------------------------------------------------- Changes included in 2018-08-24.1 --------------------------------------------------------------------- - Protein changes: Prev. Release: 4563 This Release: 4569 Removed: 1 Added: 7 Protein Removed: WP_063843217.1 catA1 Protein Added: WP_003436401.1 vanR-Cd Protein Added: WP_009889012.1 vanZ1 Protein Added: WP_011861275.1 vanS-Cd Protein Added: WP_011861276.1 vanG-Cd Protein Added: WP_020924773.1 blaAXC-1 Protein Added: WP_072310976.1 mcr-8.2 Protein Added: WP_072678505.1 blaOXA-669 - AMR HMM library Changes: Prev. Release: 563 This Release: 563 Removed: 0 Added: 0 - Protein family changes: Prev. Release: 1128 This Release: 1133 Removed: 0 Added: 5 Family Added: - blaAXC Family Added: - vanG-Cd Family Added: - vanR-Cd Family Added: - vanS-Cd Family Added: - vanZ1 --------------------------------------------------------------------- Changes included in 2018-08-01.1 --------------------------------------------------------------------- - Protein changes: Prev. Release: 4528 This Release: 4563 Removed: 0 Added: 35 Protein Added: WP_000622776.1 qacA Protein Added: WP_001159761.1 blaADC-176 Protein Added: WP_001211208.1 blaADC-175 Protein Added: WP_010730188.1 qacZ Protein Added: WP_013095270.1 blaCMH-4 Protein Added: WP_032410229.1 blaOXA-663 Protein Added: WP_033487869.1 blaACT-56 Protein Added: WP_046887417.1 blaCMH-5 Protein Added: WP_047052637.1 blaACT-55 Protein Added: WP_050861789.1 blaACT-64 Protein Added: WP_070210118.1 blaOXA-658 Protein Added: WP_094935119.1 blaACT-57 Protein Added: WP_111772163.1 blaVIM-58 Protein Added: WP_111976052.1 blaACT-60 Protein Added: WP_112017656.1 blaACT-61 Protein Added: WP_112792421.1 blaACT-59 Protein Added: WP_114699266.1 blaOXA-666 Protein Added: WP_114699267.1 blaKPC-36 Protein Added: WP_114699268.1 blaADC-174 Protein Added: WP_114699269.1 blaADC-177 Protein Added: WP_114699270.1 blaADC-178 Protein Added: WP_114699271.1 blaADC-179 Protein Added: WP_114699272.1 blaADC-180 Protein Added: WP_114699273.1 blaOXA-661 Protein Added: WP_114699274.1 blaOXA-662 Protein Added: WP_114699275.1 mcr-8.1 Protein Added: WP_114699276.1 blaOXA-659 Protein Added: WP_114699277.1 blaVIM-60 Protein Added: WP_114699278.1 mcr-5.3 Protein Added: WP_114699279.1 blaOXA-660 Protein Added: WP_114699280.1 blaIMP-76 Protein Added: WP_114699281.1 blaIMP-77 Protein Added: WP_114699282.1 blaIMP-78 Protein Added: WP_114699283.1 blaVIM-59 Protein Added: WP_114699284.1 blaCTX-M-221 - AMR HMM library Changes: Prev. Release: 557 This Release: 563 Removed: 0 Added: 6 HMM Added: NF033648.1 blaOXA-274_like HMM Added: NF033666.1 blaOXA-664_like HMM Added: NF033667.0 blaOXA-55_like HMM Added: NF033669.1 polymyxin_MCR8 HMM Added: NF033670.1 polymyxin_MCR6 HMM Added: NF033671.1 polymyxin_MCR7 - Protein family changes: Prev. Release: 1123 This Release: 1128 Removed: 0 Added: 5 Family Added: - blaOXA-266_fam Family Added: NF033648.1 blaOXA-274_like Family Added: NF033667.1 blaOXA-55_like Family Added: NF033666.1 blaOXA-664_like Family Added: NF033669.1 mcr-8 HMM Added: mcr-6 updated to NF033670.1 mcr-6 HMM Added: mcr-7 updated to NF033671.1 mcr-7 Updates in 2018-07-07.1 - Fix in amr_report.cpp to remove extra field from AMRFinder output Updates in 2018-06-27.1 - Summary: - Protein sequences - Removed 1 protein sequence - Added 290 protein sequences - Changed the names of 2 proteins - Gene families - cfr was reorganized - HMM library - 58 HMMs not in the AMR family hierarchy were removed. They were not used for AMR gene identification so this should have no effect on AMRFinder output. - The polymyxin_MCR3 HMM was updated - Details: Protein Removed: WP_063945333.1 aac(6')-IIa Protein Added: WP_000131886.1 aac(3)-VIa Protein Added: WP_000778180.1 varG Protein Added: WP_001100752.1 blaPER-10 Protein Added: WP_002812372.1 blaOXA-578 Protein Added: WP_002824679.1 blaOXA-595 Protein Added: WP_002837769.1 blaOXA-579 Protein Added: WP_002857546.1 blaOXA-592 Protein Added: WP_002889704.1 blaOXA-591 Protein Added: WP_002936877.1 blaOXA-623 Protein Added: WP_011339581.1 blaRHO Protein Added: WP_011497575.1 blaSHN-1 Protein Added: WP_011550565.1 blaMYX-1 Protein Added: WP_011638903.1 mcr-4.3 Protein Added: WP_012263521.1 mupA Protein Added: WP_012541790.1 blaLEN-28 Protein Added: WP_012698469.1 blaLHK-7 Protein Added: WP_013255389.1 blaSPS-1 Protein Added: WP_013992183.1 blaZOG-1 Protein Added: WP_014206564.1 blaOXA-642 Protein Added: WP_015058260.1 qnrS11 Protein Added: WP_015266427.1 blaECV-1 Protein Added: WP_015431537.1 blaROB-2 Protein Added: WP_015818996.1 blaTTU-1 Protein Added: WP_016252988.1 blaPDC-286 Protein Added: WP_021018581.1 catB8 Protein Added: WP_025006557.1 blaOXA-580 Protein Added: WP_026025287.1 blaALI-1 Protein Added: WP_031192893.1 aadA31 Protein Added: WP_034035338.1 blaPDC-240 Protein Added: WP_035203840.1 catA10 Protein Added: WP_038333643.1 blaEBR-2 Protein Added: WP_038640920.1 qnrB12 Protein Added: WP_041079981.1 erm(44)v Protein Added: WP_041258349.1 blaFIA-1 Protein Added: WP_041385949.1 blaSGM-2 Protein Added: WP_041449074.1 blaANA-1 Protein Added: WP_043774378.1 catA13 Protein Added: WP_043942497.1 blaPST-1 Protein Added: WP_044600959.1 blaOXA-594 Protein Added: WP_044779552.1 blaOXA-638 Protein Added: WP_048236419.1 qnrB85 Protein Added: WP_052259183.1 erm(42) Protein Added: WP_052781249.1 blaOXA-583 Protein Added: WP_052788483.1 blaOXA-611 Protein Added: WP_052788887.1 blaOXA-581 Protein Added: WP_052794776.1 blaOXA-625 Protein Added: WP_052798312.1 blaOXA-609 Protein Added: WP_052800105.1 blaOXA-597 Protein Added: WP_052803794.1 blaOXA-601 Protein Added: WP_052858477.1 blaOXA-637 Protein Added: WP_053872444.1 blaOXA-639 Protein Added: WP_053921012.1 blaOXA-603 Protein Added: WP_057036510.1 blaOXA-629 Protein Added: WP_058157026.1 blaPDC-271 Protein Added: WP_058174497.1 blaPDC-250 Protein Added: WP_058870660.1 blaOXA-651 Protein Added: WP_058951457.1 blaOXA-652 Protein Added: WP_061193431.1 blaPDC-298 Protein Added: WP_064186845.1 qnrS13 Protein Added: WP_065597326.1 blaALI-2 Protein Added: WP_065801616.1 mcr-3.20 Protein Added: WP_065908739.1 qnrB91 Protein Added: WP_070233680.1 blaOXA-614 Protein Added: WP_070698497.1 blaPDC-278 Protein Added: WP_071701819.1 qnrS12 Protein Added: WP_071846333.1 aac(6')_Serra Protein Added: WP_073669325.1 blaPDC-285 Protein Added: WP_075606311.1 blaROB-3 Protein Added: WP_078207746.1 qnrE2 Protein Added: WP_078318620.1 blaROB-4 Protein Added: WP_080699425.1 blaTEM-229 Protein Added: WP_081048762.1 blaMYO-1 Protein Added: WP_081666691.1 blaLHK-1 Protein Added: WP_085843691.1 qnrB95 Protein Added: WP_087696200.1 blaOXA-576 Protein Added: WP_087879616.1 mcr-3.19 Protein Added: WP_088303859.1 blaOXA-624 Protein Added: WP_094308975.1 mcr-3.22 Protein Added: WP_094312656.1 mcr-3.21 Protein Added: WP_094313523.1 mcr-3.23 Protein Added: WP_094321595.1 mcr-3.24 Protein Added: WP_094963248.1 aadA31 Protein Added: WP_096170112.1 qnrS14 Protein Added: WP_096865225.1 blaPER-12 Protein Added: WP_100831609.1 blaPDC-245 Protein Added: WP_103034696.1 blaROB-5 Protein Added: WP_103252528.1 mcr-3.25 Protein Added: WP_104009831.1 blaPER-11 Protein Added: WP_104009832.1 blaPDC-234 Protein Added: WP_104009833.1 blaPDC-235 Protein Added: WP_104009834.1 blaPDC-236 Protein Added: WP_104009835.1 blaPDC-237 Protein Added: WP_104009836.1 blaPDC-238 Protein Added: WP_104009837.1 blaPDC-239 Protein Added: WP_104009838.1 blaPDC-241 Protein Added: WP_104009839.1 blaPDC-242 Protein Added: WP_104009840.1 blaPDC-243 Protein Added: WP_104009841.1 blaPDC-244 Protein Added: WP_104009842.1 blaPDC-246 Protein Added: WP_104009843.1 blaPDC-247 Protein Added: WP_104009844.1 blaPDC-248 Protein Added: WP_104009846.1 blaVIM-56 Protein Added: WP_104009847.1 blaCTX-M-178 Protein Added: WP_104009848.1 blaCTX-M-187 Protein Added: WP_104009849.1 blaCMY-156 Protein Added: WP_104009850.1 mcr-1.12 Protein Added: WP_104009851.1 mcr-7.1 Protein Added: WP_104009852.1 blaIMP-71 Protein Added: WP_104009853.1 blaOXA-575 Protein Added: WP_104009854.1 blaTEM-230 Protein Added: WP_104009855.1 blaTEM-231 Protein Added: WP_104009856.1 blaPDC-227 Protein Added: WP_104009857.1 blaPDC-228 Protein Added: WP_104009858.1 blaPDC-229 Protein Added: WP_104009859.1 blaPDC-230 Protein Added: WP_104009860.1 blaPDC-231 Protein Added: WP_104009861.1 blaPDC-232 Protein Added: WP_104009862.1 blaPDC-233 Protein Added: WP_104531863.1 blaBUT-1 Protein Added: WP_104531864.1 blaBUT-2 Protein Added: WP_104531865.1 blaLHK-2 Protein Added: WP_104531866.1 blaLHK-3 Protein Added: WP_104531867.1 blaLHK-4 Protein Added: WP_104531868.1 blaLHK-5 Protein Added: WP_104531869.1 blaLHK-6 Protein Added: WP_106672612.1 blaCMY-150 Protein Added: WP_106924209.1 blaCTX-M-213 Protein Added: WP_109544237.1 tet(S) Protein Added: WP_109545031.1 dfrA14 Protein Added: WP_109545032.1 qnrB11 Protein Added: WP_109545033.1 vanY-D Protein Added: WP_109545034.1 qnrB22 Protein Added: WP_109545035.1 qacF Protein Added: WP_109545038.1 tet(33) Protein Added: WP_109545039.1 blaSTA-1 Protein Added: WP_109545040.1 chrB Protein Added: WP_109545041.1 aph(3'')-Ib Protein Added: WP_109545042.1 blaORR-1 Protein Added: WP_109545044.1 blaKPC-34 Protein Added: WP_109545045.1 qnrD3 Protein Added: WP_109545046.1 qnrB81 Protein Added: WP_109545047.1 qnrB82 Protein Added: WP_109545048.1 blaOXA-542 Protein Added: WP_109545049.1 blaNDM-20 Protein Added: WP_109545050.1 blaCRH-2 Protein Added: WP_109545051.1 blaCRH-3 Protein Added: WP_109545053.1 blaIMP-73 Protein Added: WP_109545054.1 mcr-4.5 Protein Added: WP_109545055.1 mcr-4.4 Protein Added: WP_109545056.1 mcr-1.13 Protein Added: WP_109545057.1 mcr-5.2 Protein Added: WP_109545058.1 mcr-4.2 Protein Added: WP_109545059.1 blaTEM-232 Protein Added: WP_109545060.1 blaCTX-M-208 Protein Added: WP_109545061.1 blaCTX-M-209 Protein Added: WP_109545062.1 blaCTX-M-210 Protein Added: WP_109545063.1 blaCTX-M-211 Protein Added: WP_109545064.1 blaCTX-M-212 Protein Added: WP_109545065.1 blaCMY-161 Protein Added: WP_109545066.1 blaFOX-16 Protein Added: WP_109545067.1 blaDHA-27 Protein Added: WP_109545068.1 blaDHA-26 Protein Added: WP_109545069.1 blaCTX-M-214 Protein Added: WP_109545070.1 mcr-3.12 Protein Added: WP_109545071.1 blaOXA-649 Protein Added: WP_109545072.1 blaOXA-641 Protein Added: WP_109545073.1 blaFRI-5 Protein Added: WP_109545074.1 blaGPC-1 Protein Added: WP_109545075.1 blaOXA-619 Protein Added: WP_109545076.1 blaOXA-620 Protein Added: WP_109545077.1 blaOXA-636 Protein Added: WP_109545078.1 blaOXA-635 Protein Added: WP_109545079.1 blaOXA-631 Protein Added: WP_109545080.1 blaOXA-626 Protein Added: WP_109545081.1 blaOXA-627 Protein Added: WP_109545082.1 blaOXA-633 Protein Added: WP_109545083.1 blaOXA-628 Protein Added: WP_109545084.1 blaOXA-634 Protein Added: WP_109545085.1 blaOXA-630 Protein Added: WP_109545086.1 blaOXA-632 Protein Added: WP_109545087.1 blaOXA-608 Protein Added: WP_109545088.1 blaOXA-584 Protein Added: WP_109545089.1 blaOXA-585 Protein Added: WP_109545090.1 blaOXA-586 Protein Added: WP_109545091.1 blaOXA-577 Protein Added: WP_109545092.1 blaOXA-587 Protein Added: WP_109545093.1 blaOXA-596 Protein Added: WP_109545094.1 blaOXA-600 Protein Added: WP_109545095.1 blaOXA-588 Protein Added: WP_109545096.1 blaOXA-589 Protein Added: WP_109545097.1 blaOXA-593 Protein Added: WP_109545098.1 blaOXA-599 Protein Added: WP_109545099.1 blaOXA-610 Protein Added: WP_109545100.1 blaOXA-612 Protein Added: WP_109545101.1 blaOXA-598 Protein Added: WP_109545102.1 blaOXA-607 Protein Added: WP_109545103.1 blaOXA-590 Protein Added: WP_109545104.1 blaOXA-604 Protein Added: WP_109545105.1 blaOXA-602 Protein Added: WP_109545106.1 blaOXA-606 Protein Added: WP_109545107.1 blaOXA-582 Protein Added: WP_109545108.1 blaOXA-605 Protein Added: WP_109545109.1 blaOXA-640 Protein Added: WP_109545110.1 blaOXA-616 Protein Added: WP_109545111.1 blaOXA-613 Protein Added: WP_109545112.1 blaOXA-622 Protein Added: WP_109545113.1 blaOXA-618 Protein Added: WP_109545114.1 blaOXA-617 Protein Added: WP_109545115.1 blaOXA-615 Protein Added: WP_109545116.1 blaOXA-621 Protein Added: WP_109791184.1 blaTEM-233 Protein Added: WP_109791185.1 blaPDC-251 Protein Added: WP_109791186.1 blaPDC-252 Protein Added: WP_109791187.1 blaPDC-253 Protein Added: WP_109791188.1 blaPDC-254 Protein Added: WP_109791189.1 blaPDC-255 Protein Added: WP_109791190.1 blaPDC-256 Protein Added: WP_109791191.1 blaPDC-257 Protein Added: WP_109791192.1 blaPDC-258 Protein Added: WP_109791193.1 blaPDC-259 Protein Added: WP_109791194.1 blaPDC-260 Protein Added: WP_109791195.1 blaPDC-261 Protein Added: WP_109791196.1 blaPDC-262 Protein Added: WP_109791197.1 blaPDC-263 Protein Added: WP_109791198.1 blaPDC-264 Protein Added: WP_109791199.1 blaPDC-265 Protein Added: WP_109791200.1 blaPDC-266 Protein Added: WP_109791201.1 blaPDC-267 Protein Added: WP_109791202.1 blaPDC-268 Protein Added: WP_109791203.1 blaPDC-270 Protein Added: WP_109791204.1 blaPDC-272 Protein Added: WP_109791205.1 blaPDC-273 Protein Added: WP_109791206.1 blaPDC-274 Protein Added: WP_109791207.1 blaIMP-74 Protein Added: WP_109791208.1 blaIMP-75 Protein Added: WP_109791209.1 blaCTX-M-216 Protein Added: WP_109791210.1 blaTEM-234 Protein Added: WP_109791211.1 blaCTX-M-217 Protein Added: WP_109791212.1 blaSHV-204 Protein Added: WP_109791213.1 blaNDM-22 Protein Added: WP_109791214.1 blaCTX-M-218 Protein Added: WP_109791215.1 blaCMY-160 Protein Added: WP_109791216.1 blaOXA-654 Protein Added: WP_109997726.1 qnrA9 Protein Added: WP_110092882.1 blaCTX-M-219 Protein Added: WP_111273842.1 mcr-3.13 Protein Added: WP_111273843.1 mcr-3.14 Protein Added: WP_111273844.1 mcr-3.15 Protein Added: WP_111273845.1 mcr-3.16 Protein Added: WP_111273846.1 mcr-3.17 Protein Added: WP_111273847.1 mcr-3.18 Protein Added: WP_111273848.1 blaGES-35 Protein Added: WP_111273849.1 blaGES-36 Protein Added: WP_111273850.1 blaGES-37 Protein Added: WP_111273851.1 blaCMY-162 Protein Added: WP_111273852.1 blaKPC-35 Protein Added: WP_111672883.1 blaPDC-275 Protein Added: WP_111672884.1 blaPDC-294 Protein Added: WP_111672885.1 blaPDC-295 Protein Added: WP_111672886.1 blaPDC-296 Protein Added: WP_111672887.1 blaPDC-297 Protein Added: WP_111672888.1 blaPDC-299 Protein Added: WP_111672889.1 blaPDC-300 Protein Added: WP_111672890.1 blaPDC-276 Protein Added: WP_111672891.1 blaPDC-277 Protein Added: WP_111672892.1 blaPDC-279 Protein Added: WP_111672893.1 blaPDC-280 Protein Added: WP_111672894.1 blaPDC-281 Protein Added: WP_111672895.1 blaPDC-282 Protein Added: WP_111672896.1 blaPDC-283 Protein Added: WP_111672897.1 blaPDC-284 Protein Added: WP_111672898.1 blaPDC-287 Protein Added: WP_111672899.1 blaPDC-288 Protein Added: WP_111672900.1 blaPDC-289 Protein Added: WP_111672901.1 blaPDC-290 Protein Added: WP_111672902.1 blaCTX-M-220 Protein Added: WP_111672903.1 blaPDC-291 Protein Added: WP_111672904.1 blaPDC-292 Protein Added: WP_111672905.1 blaPDC-293 Protein Added: WP_111672906.1 blaCMY-163 Protein Added: WP_111672907.1 blaOXA-657 Protein Added: WP_111672908.1 blaPDC-301 Protein Added: WP_111672909.1 blaPDC-302 Protein Added: WP_111672910.1 blaPDC-303 Protein Added: WP_111672911.1 blaKPC-23 Protein Added: WP_111672912.1 blaNDM-23 Protein Added: WP_111672913.1 blaNDM-24 Protein Added: WP_111672914.1 blaVIM-57 Protein Added: WP_111690897.1 cfr(B) Protein Added: WP_111690898.1 cfr(C) Protein Modified: WP_011987126.1 cfrC updated to WP_011987126.1 cfr-Cb Protein Modified: WP_063854808.1 qnrS updated to WP_063854808.1 qnrS10 HMM Removed: NF000031.1 MFS_efflux_LmrA HMM Removed: NF000040.1 172051428_tet HMM Removed: NF000058.1 Erm41 HMM Removed: NF000060.1 MFS_efflux_LmrB HMM Removed: NF000106.1 40850658_otr HMM Removed: NF000131.1 MATE_multi_MepA HMM Removed: NF000140.3 AAC_6p_Salmo HMM Removed: NF000217.1 MATE_multi_FepA HMM Removed: NF000247.1 MexA HMM Removed: NF000249.1 MexE HMM Removed: NF000250.1 MexH HMM Removed: NF000251.1 MexW-MexI HMM Removed: NF000252.1 MexX HMM Removed: NF000263.1 MATE_multi_NorM HMM Removed: NF000282.2 RND_permease_1 HMM Removed: NF000313.1 adeA-adeI HMM Removed: NF000314.1 adeB HMM Removed: NF000315.1 adeC-adeK-oprM HMM Removed: NF000334.3 drrA HMM Removed: NF000336.1 emrE HMM Removed: NF000342.3 glpA_Cterm HMM Removed: NF000344.1 macA HMM Removed: NF000345.1 macB HMM Removed: NF000349.1 mfpA_AE000516.2 HMM Removed: NF000352.1 norA HMM Removed: NF000357.1 romA HMM Removed: NF000391.1 EmrB HMM Removed: NF010314.2 PRK13751.2 HMM Removed: NF012135.0 ANT_3pp_9_crypt HMM Removed: NF012144.2 ramA_TF HMM Removed: NF012163.2 BaeS_SmeS HMM Removed: NF012168.1 BlaI_of_BCL HMM Removed: NF012198.0 MarA_TF HMM Removed: NF012208.0 SDR_dihy_bifunc HMM Removed: NF012226.0 AdeS_HK HMM Removed: NF012227.0 AdeR_RR HMM Removed: NF012228.1 RobA_TF HMM Removed: NF028537.1 P_eth_NH2_trans HMM Removed: NF030466.0 TIGR02052 HMM Removed: NF030467.0 TIGR02053 HMM Removed: NF033086.2 penta_rpt_Qnr HMM Removed: NF033124.1 estX HMM Removed: NF033134.0 cmlA_floR HMM Removed: NF033138.1 RND-peri-MexC HMM Removed: NF033142.1 efflux_OM_AdeC HMM Removed: NF033143.1 efflux_OM_AdeK HMM Removed: NF033184.1 B3_Acin_new1 HMM Removed: NF033480.1 bifunc_MprF HMM Removed: NF033553.1 MerP_Gpos HMM Removed: NF033555.1 lyase_MerB HMM Removed: NF033556.1 MerTP_fusion HMM Removed: NF033560.1 merT_RC607 HMM Removed: NF033565.0 trans_MerF HMM Removed: NF033606.1 heat_AAA_ClpK HMM Removed: NF033607.0 disagg_AAA_ClpG HMM Removed: NF033617.1 RND_permease_2 HMM Removed: NF033627.1 intimin_all HMM Removed: NF033636.1 acid_shock_Asr HMM Modified: NF033408.2 polymyxin_MCR3 updated to NF033408.5 polymyxin_MCR3 Family Removed: - cfrC Family Added: - cfr(B) Family Added: - cfr(C) Family Added: - cfr-Cb Family Changed: NF033408.2 mcr-3 updated to NF033408.5 mcr-3 --------------------------------------------------------------------- Changes included in 2018-05-15.1 --------------------------------------------------------------------- - Data Changes: Protein Removed: WP_010886396.1 lmr(B) HMM Added: NF033614.1 APH_6_Ic_gen HMM Added: NF033617.1 RND_permease_2 HMM Added: NF033626.1 blaBKC_GPC HMM Added: NF033627.1 intimin_all HMM Added: NF033636.1 acid_shock_Asr HMM Modified: NF000011.1 APH_6_Ic updated to NF000011.2 APH_6_Ic HMM Modified: NF000221.3 FosA updated to NF000221.4 FosA HMM Modified: NF000282.1 RND_permease_1 updated to NF000282.2 RND_permease_1 HMM Modified: NF000428.2 blaFRI updated to NF000428.4 blaFRI HMM Modified: NF033582.0 blaALI updated to NF033582.2 blaALI Family Removed: NF000060.1 lmr(B) Family Added: NF033626.1 blaBKC_GPC Family Added: - blaGPC - Algorithm Changes: - Partial proteins identified as "Method" PARTIAL if length of blast alignment > 50% and < 90% of database protein. --------------------------------------------------------------------- Changes included in 2018-05-08.1 RELEASE CANDIDATE --------------------------------------------------------------------- - Addition of handling for genbank plasmid gff --------------------------------------------------------------------- Changes included in 2018-04-16.1 --------------------------------------------------------------------- - Addition of file format checking for FASTA and GFF files before AMRFinder blast and HMM searches are run - Altered format of fam.tab file to include NF accessions for families - Removal of non-reportable families from fam.tab